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FUKUMOTO TakumiGraduate School of Medicine / Faculty of Medical SciencesProfessor
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■ Paper- BACKGROUND: Preoperative recognition of the anatomy of caudate biliary branches is important for the safe and complete resection of perihilar cholangiocarcinoma (PHC). In the present study, we identified these branches using an endoscopic nasobiliary drainage tube (ENBD). METHODS: Between January 2012 and October 2022, 89 patients with suspected PHC underwent computed tomographic (CT) cholangiography through ENBD and caudate biliary branching patterns were examined. Multidetector raw CT (MDCT) scans on 85 patients with PHC without biliary drainage were also investigated. The caudate biliary branches detected by each modality were evaluated. RESULTS: ENBD-CT cholangiography detected 206 caudate branches (2.44 branches/patient), while MDCT identified 62 branches (0.78 branches/patient). ENBD-CT cholangiography showed that 89 caudate branches drained into the left hepatic duct (LHD), 87 into the posterior hepatic duct (Bpost), and 30 into the right hepatic duct. LHD and Bpost were the common roots of the caudate branches. Some branches (20%) joined the contralateral hepatic duct across the left-right border, but not the anterior hepatic duct or infraportal-type Bpost. CONCLUSIONS: ENBD-CT cholangiography clearly showed the caudate biliary branches in patients with PHC after biliary drainage.Nov. 2024, Journal of hepato-biliary-pancreatic sciences, 31(11) (11), 809 - 815, English, Domestic magazineScientific journal
- PURPOSE: Surgeons' adaptability to robotic manipulation remains underexplored. This study evaluated the participants' first-touch robotic training skills using the hinotori surgical robot system and its simulator (hi-Sim) to assess adaptability. METHODS: We enrolled 11 robotic surgeons (RS), 13 laparoscopic surgeons (LS), and 15 novices (N). After tutorial and training, participants performed pegboard tasks, camera and clutch operations, energizing operations, and suture sponge tasks on hi-Sim. They also completed a suture ligation task using the hinotori surgical robot system on a suture simulator. Median scores and task completion times were compared. RESULTS: Pegboard task scores were 95.0%, 92.0%, and 91.5% for the RS, LS, and N groups, respectively, with differences between the RS group and LS and N groups. Camera and clutch operation scores were 93.1%, 49.7%, and 89.1%, respectively, showing differences between the RS group and LS and N groups. Energizing operation scores were 90.9%, 85.2%, and 95.0%, respectively, with a significant difference between the LS and N groups. Suture sponge task scores were 90.6%, 43.1%, and 46.2%, respectively, with differences between the RS group and LS and N groups. For the suture ligation task, completion times were 368 s, 666 s, and 1095 s, respectively, indicating differences among groups. Suture scores were 12, 10, and 7 points, respectively, with differences between the RS and N groups. CONCLUSION: First-touch simulator-based robotic skills were partially influenced by prior robotic surgical experience, while suturing skills were affected by overall surgical experience. Thus, robotic training programs should be tailored to individual adaptability.Nov. 2024, Langenbeck's archives of surgery, 409(1) (1), 332 - 332, English, International magazineScientific journal
- BACKGROUND: Particle therapy (PT) as an initial hepatocellular carcinoma (HCC) treatment has been reported to be effective; however, its efficacy for the treatment of recurrent HCC remains unclear. OBJECTIVE: This study aimed to evaluate the efficacy of PT compared with repeat liver resection for treating recurrent HCC after initial LR, with a focus on prognostic outcomes. METHODS: Between 2005 and 2019, 89 and 49 patients underwent repeat LR and PT for recurrent HCC after initial LR, respectively. The 5-year overall survival (OS) and recurrence-free survival (RFS) were evaluated using propensity score matching. Treatment-related complications were scored using the National Institute Common Terminology Criteria for Adverse Events (CTCAE) and were compared between the repeat LR and PT groups. RESULTS: In the entire cohort, the 5-year OS was significantly better in the repeat LR group than in the PT group (75% vs. 48%; p = 0.0003), and the 5-year RFS was comparable in both groups (22% vs. 13%; p = 0.088). Propensity score matching created 34 pairs of patients; no significant differences in the 5-year OS (65% vs. 48%; p = 0.310) and RFS (21% vs. 8%; p = 0.271) were observed between the repeat LR and PT groups. The proportion of CTCAE grade ≥3 complications was 8.8% and 5.9% in the repeat LR and PT groups, respectively (p = 0.641). CONCLUSIONS: After initial LR, the prognosis and treatment-related complications in patients with recurrent HCC were comparable between the repeat LR and PT groups in the matched cohort; therefore, PT may remain one of the multidisciplinary treatment options for recurrent HCC.Oct. 2024, Annals of surgical oncology, English, International magazineScientific journal
- Space-making particle therapy, which consists of surgical placement of a spacer followed by particle therapy, has become a solution to the problem of normal organs being exposed to a high radiation dose. A bioabsorbable spacer is particularly suitable for this purpose, but is not widely used. Surgical placement of a spacer is performed mostly to protect the digestive tract, but can also be used to protect the kidneys. Therefore, we have been interested in the use of space-making particle therapy to preserve renal function. A 14 month-old boy with intermediate-risk retroperitoneal rhabdomyosarcoma underwent surgery with placement of a bioabsorbable spacer following neoadjuvant chemotherapy and then received proton beam therapy of 41.4 Gy (relative biological effectiveness) in 23 fractions. In the 41 months since PBT, he has survived without local recurrence or signs of renal impairment. This report describes the first-ever case of surgical placement of a bioabsorbable spacer with the aim of preserving renal function during proton beam therapy. Space-making particle therapy is an innovative solution for peritoneal tumors adjacent to the kidneys.Oct. 2024, International cancer conference journal, 13(4) (4), 476 - 480, English, International magazineScientific journal
- BACKGROUND: Systemic inflammation and altered metabolism are essential hallmarks of cancer. We hypothesized that the rapid turnover protein transthyretin (TTR) (half-life: 2-3 days), compared with the conventional marker albumin (21 days), better reflects the inflammatory/metabolic dynamics of pancreatic ductal adenocarcinoma (PDAC) after neoadjuvant therapy (NAT) and is a useful prognostic marker. METHODS: Serum TTR and albumin levels were measured in 104 consecutive post-NAT PDAC patients before curative resection. The associations of preoperative TTR and albumin levels with overall survival (OS) after pancreatectomy were retrospectively analyzed. RESULTS: The mean (SD) TTR and albumin levels were 21.6 (6.4) mg/dL (normal range: ≥22.0 mg/dL) and 3.9 (0.55) g/dL. A low (<22.0 mg/dL) post-NAT TTR level was associated with an advanced tumor stage and higher CEA and CRP levels. Patients with low TTR levels showed significantly worse OS compared with normal levels (3-year OS 39 % vs. 54 %, P = 0.037), although albumin levels did not. We modified prognostic biomarkers of systemic inflammation/metabolism, such as GPS, PNI, and CONUT scores, using the serum TTR instead of albumin level and successfully showed that modified scores were better associated with OS compared with original scores using serum albumin level. CONCLUSIONS: Our data suggest that the TTR level is a promising prognostic biomarker for PDAC patients after NAT.Sep. 2024, Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 24(6) (6), 917 - 924, English, International magazineScientific journal
- PURPOSE: The technical difficulties of laparoscopic liver resection (LLR) are greatly associated with the location of liver tumors. Since segment 8 (S8) contains a wide area, the difficulty of LLR for S8 tumors may vary depending on the location within the segment, such as the ventral (S8v) and dorsal (S8d) area, but the difference is unclear. METHODS: We retrospectively investigated 30 patients who underwent primary laparoscopic partial liver resection for liver tumors in S8 at Kobe University Hospital between January 2018 and June 2023. RESULTS: Thirteen and 17 patients underwent LLR for S8v and S8d, respectively. The operation time was significantly longer (S8v 203[135-259] vs. S8d 261[186-415] min, P = 0.002) and the amount of blood loss was significantly higher (10[10-150] vs. 10[10-200] mL, P = 0.034) in the S8d group than in the S8v group. No significant differences were observed in postoperative complications or postoperative length of hospital stay. Additionally, intraoperative findings revealed that the rate at which the case performed partial liver mobilization in the S8d group was higher (2[15.4%] vs. 8[47.1%], P = 0.060) and the median parenchymal transection time of the S8d group was longer (102[27-148] vs. 129[37-175] min, P = 0.097) than those in the S8v group, but there were no significant differences. CONCLUSION: The safety of LLR for the S8d was comparable to that of LLR for S8v, although LLR for S8d resulted in longer operative time and more blood loss. THE TRIAL REGISTRATION NUMBER: B230165 (approved at December 26, 2023).Aug. 2024, Langenbeck's archives of surgery, 409(1) (1), 243 - 243, English, International magazineScientific journal
- (株)癌と化学療法社, Aug. 2024, 癌と化学療法, 51(8) (8), 843 - 845, Japanese
- Background Pancreatic duct (PD) disruption can occasionally be attributed to pancreatic cancer. Therapeutic interventions for PD disruption due to pancreatic cancer and their influence on pancreatic cancer prognosis remain unclear. This study investigated the therapeutic modalities and prognostic implications of PD disruption in pancreatic cancer. Methods This retrospective study included 15 patients with PD disruption concomitant with pancreatic cancer between April 2011 and March 2023. As an endoscopic intervention for PD disruption, endoscopic pancreatic stenting (EPS) or endoscopic ultrasonography-guided pancreatic fluid collection drainage (EUS-PFD) was performed. Technical success was defined as stent placement and clinical success was defined as an improvement in PD disruption. Results Of the 15 cases of PD disruption, two involved only pancreatic juice leakage without symptoms, four involved pancreatic pseudocyst (PPC) without infection, and nine involved PPC with infection. Four patients underwent EPS, nine underwent EUS-PFD, and two underwent lumen-apposing metal stent placement. All patients achieved both technical and clinical success without complications. The clinical stage of pancreatic cancer ranged from carcinoma in situ to the metastatic phase. For the treatment of pancreatic cancer, five patients underwent surgical resection, and eight underwent chemotherapy. There was no obvious recurrence of peritoneal sowing. The median overall survival from the diagnosis of pancreatic cancer in the resected and non-resected cases was 74 and 9.6 months, respectively. Conclusion Endoscopic intervention was effective in all cases of PD disruption due to pancreatic cancer. Furthermore, even in cases of pancreatic cancer after PD disruption, survival rates were similar to those in cases without PD disruption and were achieved through surgical resection or chemotherapy.Aug. 2024, Cureus, 16(8) (8), e67482, English, International magazineScientific journal
- BACKGROUND/AIM: Neskeep®, an absorbable polyglycolic acid spacer, has been developed as the optimal material for spacer placement surgery. However, preventing its severe adhesion is a crucial concern. Therefore, we aimed to identify an effective anti-adhesion agent for Neskeep® using rat models. MATERIALS AND METHODS: Animal experiments were performed using 60 rats, which underwent Neskeep® placement on the abdominal wall. Three types of anti-adhesion agents were employed, establishing four subgroups: Seprafilm®, INTERCEED®, AdSpray®, and only Neskeep® (control) groups. Rats were sacrificed on postoperative days 7, 14, and 28 to assess adhesion levels around the Neskeep® Macroscopic visual assessment with the Lauder score and histopathological evaluation were performed to assess the degree of adhesion. RESULTS: There were no significant differences in the proportion of Lauder scores on days 7 and 14 between the four groups. Histological evaluation revealed no significant differences between groups at any observation time. However, the mean Lauder scores at day 28 were 5.0, 1.6, 4.0, and 4.8 in the Neskeep®, Seprafilm®, INTERCEED®, and AdSpray® groups, respectively. The proportion of milder Lauder score was significantly higher in the Seprafilm® group on day 28. CONCLUSION: Seprafilm® may exhibit an anti-adhesive effect when used with Neskeep®.Aug. 2024, Anticancer research, 44(8) (8), 3349 - 3353, English, International magazineScientific journal
- PURPOSE: The impact of postoperative bile leak on the prognosis of patients with hepatocellular carcinoma who underwent liver resection is controversial. This study aimed to investigate the prognostic impact of bile leak for patients with hepatocellular carcinoma who underwent liver resection. METHODS: Patients with hepatocellular carcinoma who underwent liver resection between 2009 and 2019 at Kobe University Hospital and Hyogo Cancer Center were included. After propensity score matching between the bile leak and no bile leak groups, differences in 5-year recurrence-free and overall survival rates were evaluated using the Kaplan-Meier method. RESULTS: A total of 781 patients, including 43 with postoperative bile leak, were analyzed. In the matched cohort, 40 patients were included in each group. The 5-year recurrence-free survival rates after liver resection were 35% and 32% for the bile leak and no bile leak groups, respectively (P = 0.857). The 5-year overall survival rates were 44% and 54% for the bile leak and no bile leak groups, respectively (P = 0.216). CONCLUSION: Overall, bile leak may not have a profound negative impact on the prognosis of patients with hepatocellular carcinoma who have undergone liver resection.Jul. 2024, Langenbeck's archives of surgery, 409(1) (1), 233 - 233, English, International magazineScientific journal
- BACKGROUND: Few studies have compared the clinical outcomes of patients with pelvic bone sarcomas treated surgically and those treated with particle beam therapy. This is a multicenter retrospective cohort study which compared the clinical outcomes of patients with pelvic bone sarcoma who underwent surgical treatment and particle beam therapy in Japan. METHODS: A total of 116 patients with pelvic bone sarcoma treated at 19 specialized sarcoma centers in Japan were included in this study. Fifty-seven patients underwent surgery (surgery group), and 59 patients underwent particle beam therapy (particle beam group; carbon-ion radiotherapy: 55 patients, proton: four patients). RESULTS: The median age at primary tumor diagnosis was 52 years in the surgery group and 66 years in the particle beam group (P < 0.001), and the median tumor size was 9 cm in the surgery group and 8 cm in the particle beam group (P = 0.091). Overall survival (OS), local control (LC), and metastasis-free survival (MFS) rates were evaluated using the Kaplan-Meier method and compared among 116 patients with bone sarcoma (surgery group, 57 patients; particle beam group, 59 patients). After propensity score matching, the 3-year OS, LC, and MFS rates were 82.9% (95% confidence interval [CI], 60.5-93.2%), 66.0% (95% CI, 43.3-81.3%), and 78.4% (95% CI, 55.5-90.5%), respectively, in the surgery group and 64.9% (95% CI, 41.7-80.8%), 86.4% (95% CI, 63.3-95.4%), and 62.6% (95% CI, 38.5-79.4%), respectively, in the particle beam group. In chordoma patients, only surgery was significantly correlated with worse LC in the univariate analysis. CONCLUSIONS: The groups had no significant differences in the OS, LC, and MFS rates. Among the patients with chordomas, the 3-year LC rate in the particle beam group was significantly higher than in the surgery group.Jul. 2024, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, English, Domestic magazineScientific journal
- BACKGROUND: Validating the expanded criteria for living donor liver transplantation for hepatocellular carcinoma using national data is highly significant. The aim of this study was to evaluate the validity of the new Japanese criteria for living donor liver transplantation for hepatocellular carcinoma patients and identify factors associated with a poor prognosis using the Japanese national data set. METHODS: The study population comprised patients who underwent living donor liver transplantation for hepatocellular carcinoma at 37 centres in Japan between 2010 and 2018. In a nationwide survey, the overall survival and recurrence-free survival rates were evaluated based on the new Japanese criteria for applying the 5-5-500 rule when extending the indication beyond the Milan criteria. Prognostic factors within the Japanese criteria were determined using the Cox proportional hazards model. RESULTS: Patients within (485 patients) and beyond (31 patients) the Japanese criteria exhibited 5-year overall survival rates of 81% and 58% and 5-year recurrence-free survival rates of 77% and 48% respectively. Patients who met the Milan criteria, but not the 5-5-500 rule, had poorer outcomes. Multivariate analysis for 474 patients identified a neutrophil-to-lymphocyte ratio greater than or equal to 5 and a history of hepatectomy as independent risk factors. CONCLUSION: This nationwide survey confirms the validity of the Japanese criteria. The poor prognostic factors within the Japanese criteria include a neutrophil-to-lymphocyte ratio greater than or equal to 5 and previous hepatectomy.Jul. 2024, BJS open, 8(4) (4), English, International magazineScientific journal
- BACKGROUND/AIM: Sorafenib and lenvatinib have long been used as a first-line treatment for advanced hepatocellular carcinoma (HCC). Along with the development of systemic chemotherapy for HCC, the concept of conversion hepatectomy has recently become widespread. The present study aimed to assess the clinical outcomes of sorafenib and lenvatinib for HCC regarding the possibility of conversion hepatectomy in clinical practice. PATIENTS AND METHODS: A total of 295 patients with advanced HCC receiving sorafenib and lenvatinib, accounting for 306 treatments (sorafenib, n=157; lenvatinib, n=149, 11 patients received lenvatinib after sorafenib treatment) at five different institutions were enrolled. Patients were assessed for their clinical characteristics and therapeutic response using both Response Evaluation Criteria in Solid Tumors criteria (RECIST) and modified RECIST (mRECIST) criteria. Additionally, an indication of surgery after tyrosine kinase inhibitor administration was determined based on the tumor status of patients. RESULTS: The median survival times of patients treated with sorafenib and lenvatinib were 12.8 and 16.4 months, respectively, without significant difference (p=0.1645). The objective response rates (ORR) of sorafenib based on mRECIST and RECIST were 10.1% and 5.9%, respectively, and those of lenvatinib were 38.1% and 19.0%, respectively. Among the 306 treatments, two cases (sorafenib and lenvatinib, one each) underwent hepatectomy after systemic chemotherapy. CONCLUSION: Few cases with unresectable HCC were amenable to conversion hepatectomy after sorafenib and lenvatinib treatments due to the limited ORR by RECIST. Cautious approach must be taken when administering neoadjuvant chemotherapy aimed at conversion hepatectomy.Jul. 2024, Anticancer research, 44(7) (7), 3097 - 3103, English, International magazineScientific journal
- Multiple biliary tumors rarely develop in patients without underlying chronic hepatobiliary disease. Those lesions are regarded as multifocal neoplasms if there is no interconnecting dysplasia. This study aimed to determine whether 2 separate tumors in the biliary tract represent true multifocal independent tumorigenesis or intraluminal implantation of a single neoplasm. Two separate biliary tumors without intervening dysplasia were identified in 9 cases: biliary intraductal papillary neoplasm (IPNB; n=5) and extrahepatic cholangiocarcinoma (n=4). The 2 tumors were histologically similar in all cases. In 5 metachronous cases, the second tumor developed 2 to 13 years after the complete resection of the first tumor. In 4 synchronous cases, 2 separate neoplasms were identified in a surgical specimen. The metachronous presentation was more common in IPNB cases, whereas the synchronous development was more frequent in cholangiocarcinoma cases. The second tumors in 4 metachronous cases (4/5; 80%) and smaller lesions in all synchronous cases (4/4; 100%) were located in a lower part of the biliary. Immunophenotypes of cytokeratins and mucin core proteins were almost identical between the 2 lesions. Next-generation sequencing also confirmed that the 2 neoplasms shared gene mutations involving KRAS, GNAS, APC, BRAF, CTNNB1, SMAD4, TP53, or ARID1A in all cases. In conclusion, multiple biliary tumors without underlying chronic biliary disease are most likely due to intraductal implantation of a single neoplasm. Thick mucinous bile in IPNB and increasing use of trans-ampullary biliary interventions may contribute to this unique form of tumor extension.Jul. 2024, The American journal of surgical pathology, 48(11) (11), 1464 - 1471, English, International magazineScientific journal
- Tremelimumab plus durvalumab (Dur/Tre) is the first-line treatment for advanced hepatocellular carcinoma (HCC) worldwide. The present report describes the case of a 68-year-old man diagnosed with advanced HCC and a bile duct tumor thrombus (BDTT) who achieved a complete response to Dur/Tre therapy. The BDTT progressed to the bifurcation of the left and right hepatic ducts. Over time, both the tumors and BDTT progressively decreased in size, and a complete response was confirmed using the Response Evaluation Criteria in Solid Tumors (version 1.1.) 6 months after treatment administration. Subsequently, immune-related adverse events, including type 1 diabetes mellitus and diabetic ketoacidosis, emerged, leading to treatment discontinuation. The patient was undergoing outpatient follow-up in a drug-free state with no signs of recurrence 290 days after the initial administration of Dur/Tre. Although long-term and meticulous observations are required, the present findings could influence the choice of systemic chemotherapy for advanced HCC.Jul. 2024, Oncology letters, 28(1) (1), 332 - 332, English, International magazine
- BACKGROUND/AIM: The treatment algorithm for systemic therapies for advanced hepatocellular carcinoma (HCC) has changed dramatically; however, the therapeutic landscape for sequential second-line or later-line treatments, including ramucirumab, remains controversial. This study aimed to investigate the role of ramucirumab for treating HCC. PATIENTS AND METHODS: We retrospectively analyzed data from 17 patients with advanced HCC who received ramucirumab, and 8 of them who received lenvatinib re-administration after ramucirumab treatment failure. RESULTS: The median overall survival of 17 patients treated with ramucirumab was 11.5 months. The median ratios of the 1-month post-treatment α-fetoprotein (AFP) levels and albumin-bilirubin (ALBI) scores to the pre-treatment AFP levels and ALBI scores following ramucirumab treatment were 0.880 and 0.965, respectively. The median ratios of the 1-month post-treatment AFP and ALBI levels to the pre-treatment levels were 1.587 and 0.970 for mALBI grade 1/2a, and 1.313 and 0.936 for mALBI grade 2b/3, respectively. Six of the eight patients who received lenvatinib rechallenge treatment exhibited a decrease in AFP levels one month post-lenvatinib treatment. Deterioration of liver function 3 months post-lenvatinib treatment was noted in five of the eight patients who received lenvatinib rechallenge treatment after ramucirumab. CONCLUSION: Ramucirumab may be equally useful in patients with unresectable HCC who have poor liver function or whose liver function is aggravated by other therapies. Rechallenge treatment with lenvatinib after ramucirumab may be a valid treatment option for HCC.May 2024, Anticancer research, 44(5) (5), 2055 - 2061, English, International magazineScientific journal
- BACKGROUND/AIM: This study aimed to evaluate the utility of the albumin-bilirubin grade for predicting the prognosis after repeat liver resection for patients with recurrent hepatocellular carcinoma. PATIENTS AND METHODS: Ninety patients with intrahepatic recurrent hepatocellular carcinoma who underwent repeat liver resection at our institution between 2005 and 2019 were retrospectively analyzed. Cox proportional-hazards regression models evaluated independent preoperative prognostic factors, including the albumin-bilirubin grade. Prognosis differences between patients with albumin-bilirubin grades 1 and 2 were analyzed using the Kaplan-Meier method. RESULTS: Cox proportional-hazards regression analysis revealed that albumin-bilirubin grade 2 (p=0.003) and early recurrence within one year from the initial surgery (p=0.001) were independently associated with poor recurrence-free survival, and albumin-bilirubin grade 2 (p=0.020) was independently associated with poor overall survival. The five-year recurrence-free (31% and 17%, respectively) and overall (86% and 60%, respectively) survival rates after repeat liver resection for patients with albumin-bilirubin grades 1 and 2 were significantly different between groups (both p=0.003). CONCLUSION: The albumin-bilirubin grade is useful for preoperatively predicting favorable survival rates after repeat liver resection for patients with recurrent hepatocellular carcinoma. Patients with an albumin-bilirubin grade 1 are better candidates for surgical treatment of recurrent hepatocellular carcinoma.May 2024, Anticancer research, 44(5) (5), 2031 - 2038, English, International magazineScientific journal
- Novel adhesives for biological tissues offer an advanced surgical approach. Here, the authors report the development and application of solid-state adhesives consisting of porous hydroxyapatite (HAp) biocompatible ceramics as novel internal organ retractors. The operational principles of the porous solid-state adhesives are experimentally established in terms of water migration from biological soft tissues into the pores of the adhesives, and their performance is evaluated on several soft tissues with different hydration states. As an example of practical medical utility, HAp adhesive devices demonstrate the holding ability of porcine livers and on-demand detachability in vivo, showing great potential as internal organ retractors in laparoscopic surgery.May 2024, Advanced healthcare materials, 13(19) (19), e2304616, English, International magazineScientific journal
- Intrahepatic cholangiocarcinoma (iCCA) has been subclassified by its gross morphology into the mass-forming (MF), periductal-infiltrating (PI), and intraductal growth (IG) types and their combinations. This classification correlates well with clinical features; for example, MF-iCCA has less lymph-node metastasis and a better prognosis than PI-iCCA. According to the recently accumulated evidence from histological investigations, the WHO classification endorsed a subclassification scheme in which iCCA cases are classified into small- and large-duct types. Small-duct iCCA is considered to originate from septal or smaller bile ducts and is characterized by less frequent lymph-node metastasis, a favorable prognosis, and an MF appearance. Large-duct iCCA arises around the second branch of the biliary tree and has more aggressive biology and distinct genetic abnormalities. According to the practice guidelines for iCCA from the Liver Cancer Study Group of Japan and the National Comprehensive Cancer Network, upfront surgery is recommended for iCCA without distant metastasis regardless of the morphological subtype, based on clinical experience. In consideration of the biological heterogeneity of iCCA, the treatment strategy for iCCA needs to be reconsidered based on the WHO subtypes.Apr. 2024, Surgery today, English, Domestic magazineScientific journal
- (株)ニュー・サイエンス社, Apr. 2024, 細胞, 56(4) (4), 313 - 316, Japanese
- BACKGROUND: Drainage fluid amylase (DFA) is useful for predicting clinically relevant postoperative pancreatic fistula (CR-POPF) after distal pancreatectomy (DP). However, difference in optimal cutoff value of DFA for predicting CR-POPF between open DP (ODP) and laparoscopic DP (LDP) has not been investigated. This study aimed to identify the optimal cutoff values of DFA for predicting CR-POPF after ODP and LDP. METHODS: Data for 294 patients (ODP, n = 127; LDP, n = 167) undergoing DP at Kobe University Hospital between 2010 and 2021 were reviewed. Propensity score matching was performed to minimize treatment selection bias. Receiver operating characteristic (ROC) analysis was performed to determine the optimal cutoff values of DFA for predicting CR-POPF for ODP and LDP. Logistic regression analysis for CR-POPF was performed to investigate the diagnostic value of DFA on postoperative day (POD) three with identified cutoff value. RESULTS: In the matched cohort, CR-POPF rates were 24.7% and 7.9% after ODP and LDP, respectively. DFA on POD one was significantly lower after ODP than after LDP (2263 U/L vs 4243 U/L, p < 0.001), while the difference was not significant on POD three (543 U/L vs 1221 U/L, p = 0.171). ROC analysis revealed that the optimal cutoff value of DFA on POD one and three for predicting CR-POPF were different between ODP and LDP (ODP, 3697 U/L on POD one, 1114 U/L on POD three; LDP, 10564 U/L on POD one, 6020 U/L on POD three). Multivariate analysis showed that DFA on POD three with identified cutoff value was the independent predictor for CR-POPF both for ODP and LDP. CONCLUSIONS: DFA on POD three is an independent predictor for CR-POPF after both ODP and LDP. However, the optimal cutoff value for it is significantly higher after LDP than after ODP. Optimal threshold of DFA for drain removal may be different between ODP and LDP.Mar. 2024, Surgical endoscopy, 38(5) (5), 2699 - 2708, English, International magazineScientific journal
- Owing to the high objective response rate of atezolizumab plus bevacizumab (Atez/Bev) for hepatocellular carcinoma (HCC), the concept of sequential conversion to local treatment has recently become mainstream. The conversion concept is mainly applied to Barcelona Clinic for Liver Cancer (BCLC) stage B cases, and radiotherapy is rarely considered as a conversion local treatment. We herein report three patients who were treated with the novel concept of "sequential particle radiotherapy," consisting of Atez/Bev therapy followed by particle radiotherapy (PRT) for HCC with advanced portal vein tumor thrombus (Vp3/4 PVTT). All patients achieved partial response radiologically and were switched to PRT. All patients were recurrence free at 1 year after the introduction of Atez/Bev therapy without any additional treatment. This upcoming combination strategy includes the advocacy of sequential concepts for BCLC stage C cases and the introduction of PRT as a local treatment after Atez/Bev.Mar. 2024, Surgery today, 54(8) (8), 972 - 976, English, Domestic magazineScientific journal
- 金原出版(株), Mar. 2024, 手術, 78(4) (4), 535 - 544, Japanese
- BACKGROUND: Recent evidence suggests that the presence of microbiome within human pancreatic ductal adenocarcinoma (PDAC) tissue potentially influences cancer progression and prognosis. However, the significance of tumor-resident microbiome remains unclear. We aimed to elucidate the impact of intratumoral bacteria on the pathophysiology and prognosis of human PDAC. METHODS: The presence of intratumoral bacteria was assessed in 162 surgically resected PDACs using quantitative polymerase chain reaction (qPCR) and in situ hybridization (ISH) targeting 16S rRNA. The intratumoral microbiome was explored by 16S metagenome sequencing using DNA extracted from formalin-fixed paraffin-embedded tissues. The profile of intratumoral bacteria was compared with clinical information, pathological findings including tumor-infiltrating T cells, tumor-associated macrophage, fibrosis, and alterations in four main driver genes (KRAS, TP53, CDKN2A/p16, SMAD4) in tumor genomes. RESULTS: The presence of intratumoral bacteria was confirmed in 52 tumors (32%) using both qPCR and ISH. The 16S metagenome sequencing revealed characteristic bacterial profiles within these tumors, including phyla such as Proteobacteria and Firmicutes. Comparison of bacterial profiles between cases with good and poor prognosis revealed a significant positive correlation between a shorter survival time and the presence of anaerobic bacteria such as Bacteroides, Lactobacillus, and Peptoniphilus. The abundance of these bacteria was correlated with a decrease in the number of tumor-infiltrating T cells positive for CD4, CD8, and CD45RO. CONCLUSIONS: Intratumoral infection of anaerobic bacteria such as Bacteroides, Lactobacillus, and Peptoniphilus is correlated with the suppressed anti-PDAC immunity and poor prognosis.Mar. 2024, Journal of gastroenterology, 59(3) (3), 250 - 262, English, Domestic magazineScientific journal
- Spontaneous rupture of a primary hepatocellular carcinoma (HCC) is a frequently observed and fatal complication. However, the rupture of lymph node (LN) metastases from HCC is rare. A 79 year-old male with hepatitis B underwent three liver resections for HCC. Two years and 6 months after the last liver resection, enhanced computed tomography (CT) revealed a nodule with a diameter of 3 cm in the lower pole of the spleen. Splenic metastasis of HCC was suspected, and splenectomy was scheduled. During our hospital stay for a urinary tract infection before the scheduled operation, he complained of acute left-sided abdominal pain, and CT showed intra-abdominal hemorrhage due to rupture of the splenic tumor. Emergency splenectomy was performed, and the postoperative course was uneventful. Histopathological examination revealed a poorly differentiated HCC in the lower splenic pole lesion, which contained LN structures. The ruptured lesion was diagnosed as splenic hilar LN metastasis of HCC. Although laparoscopic partial liver resection was performed for intrahepatic recurrence, and atezolizumab plus bevacizumab therapy was administered for peritoneal metastases, the patient was alive 25 months after the splenectomy. Our case suggests that emergency surgery for LN metastatic rupture can achieve hemostasis and lead to improved survival outcomes.Feb. 2024, Clinical journal of gastroenterology, 17(3) (3), 557 - 562, English, Domestic magazineScientific journal
- AIM: The IMbrave150 trial revealed that atezolizumab plus bevacizumab (AtezoBv) showed a higher objective response rate (ORR) in patients with advanced hepatocellular carcinoma (HCC). Although conversion therapy after AtezoBv has been recently reported, markers predictive of its efficacy, particularly radiological imaging markers, have not yet been identified. The present study focused on tumor morphological appearance on radiological imaging and evaluated whether it could be associated with AtezoBv efficacy. METHODS: Ninety-five intrahepatic lesions in 74 patients who were given AtezoBv for advanced HCC were recruited for evaluation. The lesions were divided into two groups, simple nodular (SN group) and non-simple nodular (non-SN group), based on the gross morphology on pretreatment imaging, and retrospectively evaluated for treatment response and other relevant clinical outcomes. RESULTS: Assessing the size of individual tumors after treatment, waterfall plots showed that tumor shrinkage in the non-SN group including 56 lesions was higher than that in the SN group comprising 39 lesions. The ORR was significantly higher in the non-SN group (39.3% vs. 15.4%, p = 0.012). Additionally, the median time to nodular progression was longer in the non-SN group (21.0 months vs. 8.1 months, p = 0.119) compared to the SN group. Six patients with non-SN lesions underwent sequential local therapy. CONCLUSIONS: Atezolizumab plus bevacizumab may show increased therapeutic efficacy in patients with tumors with a higher potential for aggressive oncological behavior, such as non-SN lesions. Treatment strategies focusing on conversion therapy may be crucial in patients with non-SN lesions.Feb. 2024, Hepatology research : the official journal of the Japan Society of Hepatology, 54(8) (8), 773 - 780, English, International magazineScientific journal
- INTRODUCTION: Surgical resection is considered an effective cure for biliary tract cancer (BTC); however, the prognosis is unsatisfactory despite improved surgical techniques and perioperative management. The recurrence rate remains high even after curative resection. The efficacy of adjuvant chemotherapy in pancreatic and gastric cancers has been previously reported, and the feasibility of adjuvant therapy with S-1 has recently been reported in patients with resected BTC. We aimed to retrospectively investigate the effects of adjuvant chemotherapy with S-1 on resected advanced BTC. METHODS: We included data from 438 BTC patients who underwent resection between 2001 and 2020. After excluding patients with pTis-pT1 (n = 112) and other exclusion criteria, 266 patients were included in the analysis. RESULTS: After propensity score matching, 48 patients received S-1 adjuvant chemotherapy (S-1 group), and 48 patients received non-S1 adjuvant chemotherapy or underwent surgery alone (Non-S-1 group). The patients in the S-1 group had significantly better overall survival (OS) than those in the non-S-1 group (MST 51 vs 37 months, hazard ratio [HR]:.54, 95% confidence interval [CI]:.30-.98, P = .04). The S-1 group had a significantly better recurrence-free survival (RFS) than the non-S-1 group (94 vs 21 months, HR: .57, 95% CI: .33-.97, P = .03). Subgroup analyses for OS and RFS exhibited the benefits of S-1 in patients aged <75 years and in patients with primary sites of extrahepatic and perineural invasion and curability of R0. DISCUSSION: S-1 adjuvant therapy is promising for improving the postoperative survival of patients with resected advanced BTC, positive nerve invasion, and R0 resection.Jan. 2024, The American surgeon, 90(6) (6), 31348241227188 - 31348241227188, English, International magazineScientific journal
- BACKGROUND: Venous thromboembolism (VTE) is a potentially fatal complication of hepatectomy. The use of postoperative prophylactic anticoagulation in patients who have undergone hepatectomy is controversial because of the risk of postoperative bleeding. Therefore, we hypothesized that monitoring plasma D-dimer could be useful in the early diagnosis of VTE after hepatectomy. AIM: To evaluate the utility of monitoring plasma D-dimer levels in the early diagnosis of VTE after hepatectomy. METHODS: The medical records of patients who underwent hepatectomy at our institution between January 2017 and December 2020 were retrospectively analyzed. Patients were divided into two groups according to whether or not they developed VTE after hepatectomy, as diagnosed by contrast-enhanced computed tomography and/or ultrasonography of the lower extremities. Clinicopathological factors, including demographic data and perioperative D-dimer values, were compared between the two groups. Receiver operating characteristic curve analysis was performed to determine the D-dimer cutoff value. Univariate and multivariate analyses were performed using logistic regression analysis to identify significant predictors. RESULTS: In total, 234 patients who underwent hepatectomy were, of whom (5.6%) were diagnosed with VTE following hepatectomy. A comparison between the two groups showed significant differences in operative time (529 vs 403 min, P = 0.0274) and blood loss (530 vs 138 mL, P = 0.0067). The D-dimer levels on postoperative days (POD) 1, 3, 5, 7 were significantly higher in the VTE group than in the non-VTE group. In the multivariate analysis, intraoperative blood loss of > 275 mL [odds ratio (OR) = 5.32, 95% confidence interval (CI): 1.05-27.0, P = 0.044] and plasma D-dimer levels on POD 5 ≥ 21 μg/mL (OR = 10.1, 95%CI: 2.04-50.1, P = 0.0046) were independent risk factors for VTE after hepatectomy. CONCLUSION: Monitoring of plasma D-dimer levels after hepatectomy is useful for early diagnosis of VTE and may avoid routine prophylactic anticoagulation in the postoperative period.Jan. 2024, World journal of clinical cases, 12(2) (2), 276 - 284, English, International magazineScientific journal
- OBJECTIVE: To analyze 10,000 cases of living donor liver transplantation (LDLT) recipient data to elucidate outcomes with special reference to the graft-versus-recipient weight ratio (GRWR), based on the Japanese Liver Transplantation Society (JLTS) registry. BACKGROUND: The JLTS registry has been accurate and complete in characterizing and following trends in patient characteristics and survival of all patients with LDLT. METHODS: Between November 1989 and August 2021, 10,000 patients underwent LDLT in Japan. The procedures performed during the study period included pediatric liver transplantation (age <18 years, n = 3572) and adult liver transplantation (age ≥18 years, n=6428). Factors related to patient survival (PS) and graft survival (GS) were also analyzed. RESULTS: The GRWR was <0.7, 0.7 to <0.8, 0.8 to <3, 3 to <5, and ≥5 in 0.2%, 2.0%, 61.8%, 31.8%, and 2.6% of pediatric patients and <0.6, 0.6 to <0.7, 0.7 to <0.8, and ≥0.8 in 8.0%, 12.7%, 17.7%, and 61.5% of adult patients, respectively. Among pediatric recipients, the PS rate up to 5 years was significantly better in cases with a GRWR ≤5 than in those with a GRWR >5. When the GRWR and donor age were combined, among adult recipients 50 to 60 years old, the early PS and GS up to 5 years were significantly better in cases with a GRWR ≥0.7, than in those with a GRWR <0.7. (P = 0.02). In adults, a multivariate analysis showed that GRWR <0.6, transplant era (<2011), donor age (>60 years), recipient age (>60 years), model for end-stage liver disease score (≥20), and center volume (<10) were significant prognostic factors for long-term PS. CONCLUSION: Although a satisfactory long-term PS and GS, especially in the recent era (2011-2021), was achieved in the JLTS series, a GRWR ≥5 in pediatric cases and relatively old donors with a GRWR <0.7 in adult cases should be managed with caution.Jan. 2024, Annals of surgery, 279(1) (1), 94 - 103, English, International magazineScientific journal
- INTRODUCTION: The usefulness of gadolinium-ethoxybenzyl diethylenetriamine pentaacetate acid-enhanced magnetic resonance imaging (EOB-MRI) in assessing the functional future remnant liver volume (fFRLV) to predict post-hepatectomy liver failure (PHLF) has been previously reported. Herein, we evaluated the efficacy of this technique in patients with hepatocellular carcinoma (HCC) with a major portal vein tumor thrombus (PVTT). METHODS: This study included 21 patients with PVTT in the ipsilateral first-order branch (Vp3) and 30 patients with PVTT in the main trunk/contralateral branch (Vp4). To evaluate fFRLV, the signal intensity (SI) of the remnant liver was determined on T1-weighted images, using both conventional and newly developed methods. The fFRLV was calculated using the SI of the remnant liver and muscle, remnant liver volume, and body surface area. Preoperative factors predicting PHLF (≥grade B) in HCC patients with Vp3/4 PVTT were evaluated. RESULTS: In the Vp3 group, we found fFRLV area under the receiver-operating characteristic curves (AUCs) above 0.70 (AUC = 0.875, 0.750) using EOB-MRI results calculated using either the plot or whole method. None of the parameters in the Vp4 group had an AUC greater than 0.70. CONCLUSION: The fFRLV calculated by EOB-MRI using the whole method can be as useful as the conventional method in predicting PHLF (≥grade B) for HCC patients with Vp3 PVTT.2024, Digestive surgery, 41(1) (1), 30 - 36, English, International magazineScientific journal
- BACKGROUND: The safety and efficacy of laparoscopic liver resection (LLR) have been reported worldwide. However, those of LLR for tumors located in Couinaud's segment 8 are not sufficiently investigated. METHODS: We retrospectively analyzed 108 patients who underwent liver resection for hepatocellular carcinoma (HCC) in segment 8 at Kobe University Hospital and Hyogo Cancer Center between January 2010 and December 2021. The patients were categorized in LLR and open liver resection (OLR) groups, and 1:1 propensity score matching (PSM) was performed to compare surgical outcomes between the groups. RESULTS: Forty-seven and 61 patients underwent LLR and OLR, respectively. After PSM, each group contained 34 patients. There was no significant difference in operation time between the groups (331 min vs. 330 min, P = 0.844). Patients in the LLR group had significantly less blood loss (30 mL vs. 468 mL, P < 0.001) and shorter length of postoperative hospital stay (10 days vs. 12 days, P = 0.015) than those in the OLR group. There was no significant difference in the occurrence of postoperative complications between the groups (12% vs. 9%, P = 0.690). Further, the 1-year cumulative incidence of recurrence was not significantly different between the groups (16% vs. 19%, P = 0.734). CONCLUSIONS: The surgical outcomes and short-term prognosis of LLR were similar or better than those of OLR. LLR could be an effective and safe procedure, even for lesions located in segment 8, which is considered a difficult anatomical location for LLR.Nov. 2023, Surgical endoscopy, 37(11) (11), 8438 - 8446, English, International magazineScientific journal
- BACKGROUND: Spacer placement surgery is useful in particle therapy (PT) for patients with abdominopelvic malignant tumors located adjacent to the gastrointestinal tract. This study aimed to assess the safety, efficacy, and long-term outcomes of spacer placement surgery using an expanded polytetrafluoroethylene (ePTFE) spacer. METHODS: This study included 131 patients who underwent ePTFE spacer placement surgery and subsequent PT between September 2006 and June 2019. The overall survival (OS) and local control (LC) rates were calculated using Kaplan-Meier method. Spacer-related complications were classified according to the National Cancer Institute Common Terminology Criteria for Adverse Events (version 5.0). RESULTS: The median follow-up period after spacer placement surgery was 36.8 months. The 3-year estimated OS and LC rates were 60.5% and 76.5%, respectively. A total of 130 patients (99.2%) were able to complete PT. Spacer-related complications of ≥ grade 3 were observed in four patients (3.1%) in the acute phase and 13 patients (9.9%) in the late phase. Ten patients (7.6%) required removal of the ePTFE spacer. CONCLUSIONS: Spacer placement surgery using an ePTFE spacer for abdominopelvic malignant tumors is technically feasible and acceptable for subsequent PT. However, severe spacer-related late complications were observed in some patients. Since long-term placement of a non-absorbable ePTFE spacer is associated with risks for morbidity and infection, careful long-term follow-up and prompt therapeutic intervention are essential when complications associated with the ePTFE spacer occur. TRIAL REGISTRATION: retrospectively registered.Oct. 2023, Radiation oncology (London, England), 18(1) (1), 173 - 173, English, International magazineScientific journal
- Oct. 2023, Annals of surgical oncology, 30(11) (11), 6611 - 6612, English, International magazineScientific journal
- BACKGROUND: Few reports have discussed the association between total tumor volume (TTV) and prognosis in patients with colorectal liver metastases (CRLM). The present study aimed to evaluate the usefulness of TTV for predicting recurrence-free survival and overall survival (OS) in patients receiving initial hepatic resection or chemotherapy, and to investigate the value of TTV as an indicator for optimal treatment selection for patients with CRLM. PATIENTS AND METHODS: This retrospective cohort study included patients with CRLM who underwent hepatic resection (n = 93) or chemotherapy (n = 78) at the Kobe University Hospital. TTV was measured using 3D construction software and computed tomography images. RESULTS: A TTV of 100 cm3 has been previously reported as a significant cut-off value for predicting OS of CRLM patients receiving initial hepatic resection. For patients receiving hepatic resection, the OS for those with a TTV ≥ 100 cm3 was significantly reduced compared with those with a TTV < 100 cm3. For patients receiving initial chemotherapy, there were no significant differences between the groups divided according to TTV cut-offs. Regarding OS of patients with TTV ≥ 100 cm3, there was no significant difference between hepatic resection and chemotherapy (p = 0.160). CONCLUSIONS: TTV can be a predictive factor of OS for hepatic resection, unlike for initial chemotherapy treatment. The lack of significant difference in OS for CRLM patients with TTV ≥ 100 cm3, regardless of initial treatment, suggests that chemotherapeutic intervention preceding hepatic resection may be indicated for such patients.Oct. 2023, Annals of surgical oncology, 30(11) (11), 6603 - 6610, English, International magazineScientific journal
- BACKGROUND: Postoperative cholangitis is a common complication of pancreaticoduodenectomy. Frequent cholangitis impairs patients' quality of life after pancreaticoduodenectomy. However, the risk factors for recurrence of cholangitis remain unclear. Hence, this retrospective study aimed to identify risk factors for recurrence of cholangitis after pancreaticoduodenectomy. METHODS: The medical records of patients who underwent pancreaticoduodenectomy between 2015 and 2019 in our institution were retrospectively reviewed. At least two episodes of cholangitis a year after pancreaticoduodenectomy were defined as 'recurrence of cholangitis' in the present study. Univariate and multivariate analyses were performed. RESULTS: The recurrence of cholangitis occurred in 40 of 207 patients (19.3%). Multivariate analysis revealed that internal stent (external, RR: 2.16, P = 0.026; none, RR: 4.76, P = 0.011), firm pancreas (RR: 2.61, P = 0.021), constipation (RR: 3.49, P = 0.008), and postoperative total bilirubin>1.7 mg/dL (RR: 2.94, P = 0.006) were risk factors of recurrence of cholangitis. Among patients with internal stents (n = 54), those with remnant stents beyond 5 months had more frequent recurrence of cholangitis (≥5 months, 75%; <5 months, 30%). CONCLUSIONS: Internal stents, firm pancreas, constipation, and postoperative high bilirubin levels are risk factors for cholangitis recurrence after pancreaticoduodenectomy. In addition, the long-term implantation of internal stents may trigger cholangitis recurrence.Oct. 2023, World journal of surgery, 47(10) (10), 2499 - 2506, English, International magazineScientific journal
- BACKGROUND: Although genome duplication, or polyploidization, is believed to drive cancer evolution and affect tumor features, its significance in hepatocellular carcinoma (HCC) is unclear. We aimed to determine the characteristics of polyploid HCCs by evaluating chromosome duplication and to discover surrogate markers to discriminate polyploid HCCs. METHODS: The ploidy in human HCC was assessed by fluorescence in situ hybridization for multiple chromosomes. Clinicopathological and expression features were compared between polyploid and near-diploid HCCs. Markers indicating polyploid HCC were explored by transcriptome analysis of cultured HCC cells. RESULTS: Polyploidy was detected in 36% (20/56) of HCCs and discriminated an aggressive subset of HCC that typically showed high serum alpha-fetoprotein, poor differentiation, and poor prognosis compared to near-diploid HCCs. Molecular subtyping revealed that polyploid HCCs highly expressed alpha-fetoprotein but did not necessarily show progenitor features. Histological examination revealed abundant polyploid giant cancer cells (PGCCs) with a distinct appearance and frequent macrotrabecular-massive architecture in polyploid HCCs. Notably, the abundance of PGCCs and overexpression of ubiquitin-conjugating enzymes 2C indicated polyploidy in HCC and efficiently predicted poor prognosis in combination. CONCLUSIONS: Histological diagnosis of polyploidy using surrogate markers discriminates an aggressive subset of HCC, apart from known HCC subgroups, and predict poor prognosis in HCC.Oct. 2023, British journal of cancer, 129(8) (8), 1251 - 1260, English, International magazineScientific journal
- In the 23rd Nationwide Follow-up Survey of Primary Liver Cancer in Japan, data from 20,889 newly registered patients and 42,274 previously registered follow-up patients were compiled from 516 institutions over a 2-year period from 1 January 2014 to 31 December 2015. Basic statistics compiled for patients newly registered in the 23rd survey was cause of death, past medical history, clinical diagnosis, imaging diagnosis, treatment-related factors, pathological diagnosis, recurrence status, and autopsy findings. Compared with the previous 22nd survey, the population of patients with hepatocellular carcinoma (HCC) was older at the time of clinical diagnosis, had more female patients, had more patients with non-B non-C HCC, had smaller tumor diameter, and was more frequently treated with hepatectomy. Cumulative survival rates were calculated for HCC, intrahepatic cholangiocarcinoma (ICC), and combined hepatocellular cholangiocarcinoma (combined HCC and ICC) by treatment type and background characteristics for patients newly registered between 2004 and 2015 whose final outcome was survival or death. Median overall survival and cumulative survival rates for HCC were calculated by dividing patients by combinations of background factors (number of tumors, tumor diameter, Child-Pugh grade, or ALBI grade) and by treatment type (hepatectomy, radiofrequency ablation therapy [RFA], transcatheter arterial chemoembolization [TACE], hepatic arterial infusion chemotherapy [HAIC] and systemic therapy). The same values were also calculated according to registration date by dividing patients newly registered between 1978 and 2015 into five time period groups. The data obtained from this nationwide follow-up survey are expected to contribute to advancing clinical research and treatment of primary liver cancer in the world. This article is protected by copyright. All rights reserved.Oct. 2023, Hepatology research : the official journal of the Japan Society of Hepatology, 53(10) (10), 895 - 959, English, International magazineScientific journal
- BACKGROUND: Particle therapy (PT) has favorable dose distribution and high curability. However, radiotherapy for malignant tumors adjacent to the gastrointestinal tract is contraindicated owing to its low tolerance. To overcome this, combination treatment with surgery to make a space between the tumor and adjacent gastrointestinal tract followed by PT has been developed. Several materials have been used for the spacer, and we have recently developed the absorbable polyglycolic acid (PGA) spacer, which has been used since 2019. This study is the first report of consecutive case series of spacer placement surgery using the PGA spacer. STUDY DESIGN: Fifty consecutive patients undergoing spacer placement surgery with the PGA spacer were evaluated. Postoperative laboratory data, morbidity related to the treatment, and spacer volume after treatment were evaluated. RESULTS: There were no treatment-related deaths, and all but two patients completed combination treatment. The median ratios of post-operative PGA spacer volume to the pre-treatment volume were 96.9%, 87.7%, and 74.6% at weeks 2, 4, and 8, respectively. The spacer volume was maintained at 80% at 7 weeks and was predicted to be 50% at 15 weeks and 20% in 24 weeks. CONCLUSIONS: Spacer placement surgery using the PGA spacer was feasible and tolerable. The PGA spacers maintained sufficient thickness during the duration of subsequent PT. Combination treatment using the PGA spacer is innovative and has the potential to become a new standard curative local treatment.Sep. 2023, Journal of the American College of Surgeons, 238(1) (1), 119 - 128, English, International magazineScientific journal
- BACKGROUND: In Japan, there are very few cases of deceased donor liver transplantation (DDLT) and even fewer studies on the effects of DDLT on sarcopenia. This study examined the changes in skeletal muscle mass and quality in DDLT, the factors related to these changes, and survival rates. METHODS: Using computed tomography (CT), we retrospectively measured L3 skeletal muscle index (L3SMI) and intramuscular adipose tissue content (IMAC) at admission, discharge, and 1-year post-DDLT in 23 patients with DDLT from our hospital between 2011 and 2020. We investigated the relationships between changes in L3SMI and IMAC associated with DDLT and between various admission factors and survival. RESULTS: Patients with DDLT showed significant decreases in L3SMI during hospitalization (P < .05). Although L3SMI tended to increase postdischarge, in 11 (73%) cases, it was lower at 1-year post-DDLT than that on admission. Moreover, decreases in L3SMI during hospitalization were correlated to L3SMI on admission (r = 0.475, P < 0.05). Intramuscular adipose tissue content increased from admission to discharge and decreased 1-year post-DDLT. Admission L3SMI and IMAC were not significantly correlated with survival. CONCLUSIONS: This study suggests that the skeletal muscle mass of DDLT patients decreased during hospitalization and showed a slight tendency to improve after discharge, but the decrease tended to be prolonged. In addition, patients with higher skeletal muscle mass at admission tended to lose more skeletal muscle mass during hospitalization. Deceased donor liver transplantation was identified as a potential contributor to improved muscle quality, whereas skeletal muscle mass and quality on admission did not affect post-DDLT survival.Sep. 2023, Transplantation proceedings, 55(7) (7), 1649 - 1655, English, International magazineScientific journal
- BACKGROUND: The exfoliative cell analyzer, LC-1000, is medical device that utilizes the principles of flow cytometry, and might provide digital diagnostic information for cytology using a different approach from conventional cytomorphology. In this study, wae examined the usefulness of the LC-1000 as a diagnostic support system for intraoperative peritoneal lavage cytology and its prognostic impact for pancreatic (PC) and biliary tract cancer (BTC). METHODS: Patients with PC and BTC who underwent surgical treatment were included. First, we identified useful indicators of LC-1000 and established cutoff values to discriminate positive cytology. Next, we verified the validity of these cutoff values. RESULTS: In the test set (n = 48), of the LC-1000 indicators examined, only MR-CPIx was significantly different between the negative and positive cytology groups, yielding a cutoff value of 0.86. In the validation set (n = 52), the sensitivity, specificity, positive and negative predictive value of the LC-1000 for cytology results was 1.0, 0.49, 0.11 and 1.0, respectively. In patients who had undergone radical resection, recurrence-free survival rate was significantly higher in the LC-1000 negative group than in the positive group in PC, but not in BTC. CONCLUSION: The LC-1000 was useful as digital support system for peritoneal cytology, and it might have potential as a prognostic factor for PC.Sep. 2023, Journal of hepato-biliary-pancreatic sciences, 30(9) (9), 1119 - 1128, English, Domestic magazineScientific journal
- BACKGROUND: The Global Leadership Initiative on Malnutrition (GLIM), comprising several of the major global clinical nutrition societies, suggested the world's first criteria for diagnosis of the severity of malnutrition. However, the impact of the resulting diagnosis on patient outcomes for those with hepatocellular carcinoma (HCC) following liver resection (LR) has not been investigated. METHODS: A retrospective analysis of 293 patients with HCC who underwent LR between January 2011 and December 2018 was performed. We compared overall survival (OS) and recurrence-free survival (RFS) and evaluated prognostic factors after LR using Cox proportional hazards regression models. RESULTS: Preoperative patient nutritional status, n (%), was classified as follows: normal, 130 (44%), moderate malnutrition, 116 (40%), and severe malnutrition, 47 (16%). The median OS (129 vs. 43 months, p < 0.001) and median RFS (54 vs. 20 months, p = 0.001) were significantly greater in the normal group than in the severe malnutrition group. Multivariate analysis showed that severe malnutrition was a significant risk factor for OS (p = 0.006) and RFS (p = 0.010) after initial LR. CONCLUSION: Severe malnutrition, as diagnosed by the GLIM criteria, is a significant prognostic factor for survival and recurrence in patients with HCC after LR.Aug. 2023, HPB : the official journal of the International Hepato Pancreato Biliary Association, 25(12) (12), 1555 - 1565, English, International magazineScientific journal
- BACKGROUND: Long-term outcomes and prognostic factors of proton radiotherapy for locally advanced pancreatic cancer (LAPC) in the body and tail are still unknown. The aim of this study was to determine the prognostic factors after proton radiotherapy in a large group of patients with LAPC in the body and tail. METHODS: The medical records of 200 patients with LAPC in the body and tail who underwent proton radiotherapy between February 2009 and January 2021 at the Hyogo Ion Beam Medical Center were retrospectively reviewed to identify prognostic factors that contribute to long-term survival. RESULTS: The overall survival rate at 1- and 2-year after PT was 69.6% and 35.4% with a median overall survival of 18.4 months. The 1- and 2-year local progression-free, and progression-free survival rates were 84.3% and 68.0%, and 44.3% and 19.4%, respectively. In multivariate analysis, superior mesenteric artery (SMA) invasion (SMA only invasion vs. celiac artery only invasion; P = 0.049: SMA and celiac artery invasion vs. celiac artery only invasion; P = 0.017), carbohydrate antigen 19-9 (CA 19-9) level ≥ 231.9 U/mL (P = 0.001), anterior peripancreatic invasion (P = 0.006), and incomplete scheduled concurrent chemotherapy (P = 0.009) were statistically significant prognostic factors for overall survival. There was no significant difference in local progression-free survival; however, distant metastasis-free survival was statistically worse in patients with prognostic factors than in those without. CONCLUSIONS: Proton radiotherapy for LAPC in the body and tail may be a valuable multidisciplinary treatment option. Patients with SMA invasion, higher pre-proton radiotherapy serum CA 19-9 level, anterior peripancreatic invasion, or incomplete scheduled concurrent chemotherapy had worse overall survival because of worse distant metastasis-free survival, suggesting that distant metastases have a significant impact on overall survival in such patients. TRIAL REGISTRATION: Retrospectively registered.Aug. 2023, Radiation oncology (London, England), 18(1) (1), 131 - 131, English, International magazineScientific journal
- BACKGROUND: Less intra-abdominal adhesions are expected following laparoscopic surgery. Although an initial laparoscopic approach for primary liver tumors may have advantages in patients who require repeat hepatectomies for recurrent liver tumors, this has not been sufficiently investigated. METHODS: Patients who underwent repeat hepatectomies for recurrent liver tumors at our hospital between 2010 and 2022 were retrospectively analyzed. Of 127 patients, 76 underwent laparoscopic repeat hepatectomy (LRH), of whom 34 patients initially underwent laparoscopic hepatectomy (L-LRH) and 42, open hepatectomy (O-LRH). Fifty-one patients underwent open hepatectomy as both the initial and second operation (O-ORH). We analyzed surgical outcomes between L-LRH and O-LRH groups and between L-LRH and O-ORH groups using propensity-matching analysis for each pattern. RESULTS: Twenty-one patients each were included in L-LRH and O-LRH propensity-matched cohorts. The L-LRH group had a lower rate of postoperative complications than the O-LRH group (0 vs 19%, P = 0.036). When we compared surgical outcomes between L-LRH and O-ORH groups in another matched cohort with 18 patients in each group, in addition to the lower rate of postoperative complications, the L-LRH group had additional favorable surgical outcomes including shorter operation time and lower blood loss volume than the O-ORH group (291 vs 368 min, P = 0.037 and 10 vs 485 mL, P < 0.0001). CONCLUSIONS: An initial laparoscopic approach would be favorable for patients undergoing repeat hepatectomies, as it leads to lower risk of postoperative complications. Compared with O-ORH, the advantage of the laparoscopic approach may be enhanced when it is repeatedly adopted.Aug. 2023, Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 27(8) (8), 1621 - 1631, English, International magazineScientific journal
- BACKGROUND/AIM: In pathology, the digitization of tissue slide images and the development of image analysis by deep learning have dramatically increased the amount of information obtainable from tissue slides. This advancement is anticipated to not only aid in pathological diagnosis, but also to enhance patient management. Deep learning-based image cytometry (DL-IC) is a technique that plays a pivotal role in this process, enabling cell identification and counting with precision. Accurate cell determination is essential when using this technique. Herein, we aimed to evaluate the performance of our DL-IC in cell identification. MATERIALS AND METHODS: Cu-Cyto, a DL-IC with a bit-pattern kernel-filtering algorithm designed to help avoid multi-counted cell determination, was developed and evaluated for performance using tumor tissue slide images with immunohistochemical staining (IHC). RESULTS: The performances of three versions of Cu-Cyto were evaluated according to their learning stages. In the early stage of learning, the F1 score for immunostained CD8+ T cells (0.343) was higher than the scores for non-immunostained cells [adenocarcinoma cells (0.040) and lymphocytes (0.002)]. As training and validation progressed, the F1 scores for all cells improved. In the latest stage of learning, the F1 scores for adenocarcinoma cells, lymphocytes, and CD8+ T cells were 0.589, 0.889, and 0.911, respectively. CONCLUSION: Cu-Cyto demonstrated good performance in cell determination. IHC can boost learning efficiencies in the early stages of learning. Its performance is expected to improve even further with continuous learning, and the DL-IC can contribute to the implementation of precision oncology.Aug. 2023, Anticancer research, 43(8) (8), 3755 - 3761, English, International magazineScientific journal
- Pancreatic cancer primarily arises from microscopic precancerous lesions, such as pancreatic intraepithelial neoplasia (PanIN) and acinar-to-ductal metaplasia (ADM). However, no established method exists for predicting pancreatic precancerous conditions. Endoscopic ultrasonography (EUS) can detect changes in pancreatic parenchymal histology, including fibrosis. This study aimed to elucidate the relationship between pancreatic parenchymal EUS findings and microscopic precancerous lesions. We retrospectively analyzed 114 patients with pancreatobiliary tumors resected between 2010 and 2020 and evaluated the association between pancreatic parenchymal EUS findings and the number of PanIN, ADM, and pancreatic duct gland (PDG). Of the 114 patients, 33 (29.0%), 55 (48.2%), and 26 (22.8%) had normal EUS findings, hyperechoic foci/stranding without lobularity, and hyperechoic foci/stranding with lobularity, respectively. Multivariate analyses revealed that abnormal EUS findings were significantly associated with the frequency of PanIN (hyperechoic foci/stranding without lobularity: OR [95% CI] = 2.7 [1.0-7.3], with lobularity: 6.5 [1.9-22.5], Ptrend = 0.01) and ADM (hyperechoic foci/stranding without lobularity: 3.1 [1.1-8.2], with lobularity: 9.7 [2.6-36.3], Ptrend = 0.003) but not with PDG (hyperechoic foci/stranding without lobularity: 2.2 [0.8-5.8], with lobularity: 3.2 [1.0-10.2], Ptrend = 0.12). We observed a trend toward a significantly higher number of precancerous lesions in the following order: normal findings, hyperechoic foci/stranding without lobularity, and hyperechoic foci/stranding with lobularity. Pancreatic parenchymal EUS findings were associated with the increased frequency of PanIN and ADM. Lobularity may help predict the increased number of precancerous lesions.Jul. 2023, Scientific reports, 13(1) (1), 12052 - 12052, English, International magazineScientific journal
- BACKGROUND: Abundant collagen deposition is a hallmark of pancreatic ductal adenocarcinomas (PDACs). This study clarified the interactive relationship between tumor-stromal collagen, molecular and immune characteristics, and tumor pr ogression in human PDAC. METHODS: We performed a comprehensive examination using an integrative molecular pathological epidemiology database on 169 cases with resected PDAC . The amount of tumor-stromal collagen was quantified through digital imaging analysis for Elastica van Gieson-stained whole-section tumor slides. We analyzed the association of tumor-stromal collagen with gene alterations (KRAS, TP53, CDKN2A/p16, and SMAD4), immune parameters (CD4+ tumor-infiltrating lymphocytes [TILs], CD8+ TILs, FOXP3+ TILs, and tertiary lymphoid structures), and patient prognosis. RESULTS: Low amounts of tumor-stromal collagen were associated with poor differentiation (multivariable OR = 3.82, 95%CI = 1.41-12.2, P = 0.008) and CDKN2A/p16 alteration (OR [95%CI] = 2.06 [1.08-4.02], P = 0.03). Tumors with low collagen levels had shorter overall survival (HR [95%CI] = 2.38 [1.59-3.56], P < 0.0001). In the S-1 and gemcitabine (GEM) treatment groups, low tumor-stromal collagen was linked to poor prognosis of patients with PDAC (S-1 group: multivariable HR [95%CI] = 2.76 [1.36-5.79], P = 0.005; GEM group: multivariate HR [95%CI] = 2.91 [1.34-6.71], P = 0.007). Additionally, low amounts of tumor-stromal collagen were also linked to low levels of CD4+ TILs (P = 0.046), CD8+ TILs (P = 0.09), and tertiary lymphoid structures (P = 0.001). CONCLUSIONS: Tumor-stromal collagen deposition may play a crucial role in modulating tumor-immune microenvironment and determining response to adjuvant chemotherapy and patient survival outcomes.Jul. 2023, Journal of gastroenterology, 58(10) (10), 1055 - 1067, English, Domestic magazineScientific journal
- UNLABELLED: Wnt signaling is known to maintain two cell states, hepatocyte differentiation and proliferation, in hepatocellular carcinoma (HCC). On the other hand, activation of Wnt signaling in colon cancer promotes uncontrollable stereotypic proliferation, whereas cells remain undifferentiated. To elucidate the unique mode of Wnt signaling in HCC, we comprehensively investigated HCC-specific Wnt pathway target genes and identified GREB1. Wnt signaling induced expression of GREB1 coupled with HNF4α and FOXA2, master transcription factors that maintain hepatic differentiation. Moreover, GREB1 was enriched at the regulatory region of atypical HNF4α target genes, including progrowth genes, thereby stimulating HCC proliferation. Therefore, GREB1 acts as a unique mediator of versatile Wnt signaling in HCC progression, bridging the roles of the Wnt pathway in differentiation and proliferation. SIGNIFICANCE: GREB1 is a liver cancer-specific Wnt signaling target gene that induces an oncogenic shift of HNF4α, a putative tumor suppressor, and may represent a therapeutic target in Wnt-activated hepatocellular carcinoma.Jul. 2023, Cancer research, 83(14) (14), 2312 - 2327, English, International magazineScientific journal
- BACKGROUND AND PURPOSE: To examine the role of proton beam therapy (PBT) in the treatment of extrahepatic biliary tract cancer (EBC). METHODS AND MATERIALS: We analyzed the data accumulated in the Proton-Net database, which prospectively registered all individual patient data treated with PBT in all Japanese proton institutions from May 2016 to June 2019. The primary endpoint was overall survival (OS), and the secondary endpoints were local control (LC), progression-free survival (PFS), and toxicity. RESULTS: Ninety-three patients with unresectable and/or recurrent EBC were treated with PBT using a median prescribed dose of 67.5 Gy (RBE) (range, 50-72.6 Gy) in 25 (22-30 fractions). With a median follow-up of 16.3 months, the median survival time was 20.1 months and the 2-year OS was 37.8%. Two-year PFS and LC rates were 20.6% and 66.5%, respectively. Poor liver function (Child-Pugh B, C), a narrower distance between the tumor and digestive tract (2 cm >), and a larger tumor diameter (2 cm <) were identified as poor prognostic factors for OS. PBT-related grade 3 ≤ acute and late adverse events occurred in 5.4% and 4.3% of patients, respectively, including one gastrointestinal late toxicity (duodenal ulcer). CONCLUSIONS: This is the largest prospectively accumulated series of PBT for EBC, and PBT showed favorable outcomes with acceptable toxicity profiles.Jul. 2023, Clinical and translational radiation oncology, 41, 100634 - 100634, English, International magazineScientific journal
- BACKGROUND AND AIM: The purpose of this study was to analyze factors associated with the overall survival (OS) of atezolizumab/bevacizumab combination therapy for advanced hepatocellular carcinoma (aHCC). We also assessed the OS of patients with ineffective therapy and those who discontinued treatment owing to adverse events (AEs). METHODS: This retrospective multicenter study involved 139 patients with aHCC who received atezolizumab/bevacizumab combination therapy between November 2020 and September 2022. RESULTS: The median duration of treatment was 136.5 days, and the median observation period was 316 days. The overall response rate was 40%, and the disease control rate was 78% according to mRECIST criteria. Grade ≥2 AEs occurred in 63 patients (43%) and led to treatment discontinuation in 16 patients. Multivariate analysis revealed that treatment response and occurrence of grade ≥2 AEs after therapy, as well as low level of albumin-bilirubin (ALBI) grade and low level of des-gamma carboxy prothrombin (DCP) before therapy, were extracted as factors that contributed to OS. Log-rank tests with the Kaplan-Meier method showed significant differences in OS among these factors. The OS of patients who discontinued owing to AEs was significantly shorter than that of other patients. CONCLUSION: Not only factors before therapy but also treatment response and the appearance of AEs are involved in OS for atezolizumab/bevacizumab combination therapy. Although the development of AEs also contributed to OS, appropriate management of AEs is important to avoid discontinuing treatment with this combination.Jul. 2023, JGH open : an open access journal of gastroenterology and hepatology, 7(7) (7), 476 - 481, English, International magazineScientific journal
- Transarterial chemoembolization (TACE) is performed for pancreatic neuroendocrine tumor (PanNEN) liver metastases; however, the safety and efficacy of TACE procedures, especially for patients who have undergone previous pancreatic surgery, have not been established. We reviewed 48 TACE procedures (1-6 procedures/patient) performed on 11 patients with PanNEN liver metastases, including 16 TACE procedures (4-6 procedures/patient) for 3 patients with a history of biliary-enteric anastomosis. The overall tumor objective response rate was 94%. The incidence of Clavien‒Dindo grade ≥ 2 complications was 1/16 (6%) and 1/32 (3%), and the median time to untreatable progression was 31 (14-41) and 27 (2-60) months among patients with and without a history of biliary-enteric anastomosis, respectively. Although validation is needed in future studies, our experiences have shown that TACE treatment is a viable treatment option for PanNEN liver metastases, even after biliary-enteric anastomosis with experienced teams and careful patient follow-up.Jun. 2023, Surgery today, 53(12) (12), 1396 - 1400, English, Domestic magazineScientific journal
- Particle beam therapy (PT) is a potentially promising approach to the treatment of extrahepatic biliary cancer (EBC) because of its unique dose distribution using the Bragg peak. However, the superiority of PT to photon radiotherapy (XT) remains unclear. Therefore, we conducted a systematic review and meta-analysis to compare PT and XT for the treatment of EBC. The primary endpoint was overall survival (OS), which was pooled using a random-effects model. Nine articles comprising a total of 1558 patients (seven XT articles, n = 1488 patients; two PT articles, n = 70 patients) were screened. In addition, we compared the outcomes of XT and PT with the outcomes available from a prospective data registry (proton-net). The 1-year OS probability rates were 55, 65 and 72% for the XT group, PT group and PT registry, respectively. The 2-year OS probability rates were 26, 38 and 38% for the XT group, PT group and PT registry, respectively. The 3-year OS probability rates were 12, 35 and 18% for the XT group, PT group and PT registry, respectively. Although the difference between the 1-year OS rates of the XT group and PT registry was statistically significant, no other significant superiority was observed among these groups. In conclusion, the efficacy of PT was not superior to that of XT during this meta-analysis.Jun. 2023, Journal of radiation research, 64(Supplement_1) (Supplement_1), i34-i40, English, International magazineScientific journal
- BACKGROUND: Optimal management of non-functioning pancreatic neuroendocrine tumors (PanNETs) ≤20 mm is controversial. The biological heterogeneity of these tumors poses challenges when deciding between resection and observation. METHODS: In this multicenter, retrospective cohort study, we analyzed all patients (n = 78) who underwent resection of non-functioning PanNETs ≤20 mm at three tertiary medical centers from 2004 to 2020 to assess the utility of preoperatively available radiological features and serological biomarkers of non-functioning PanNETs in choosing an optimal surgical indication. The radiological features included non-hyper-attenuation pattern on enhancement computed tomography (CT; hetero/hypo-attenuation) and main pancreatic duct (MPD) involvement, and serological biomarkers included elevation of serum elastase 1 and plasma chromogranin A (CgA) levels. RESULTS: Of all small non-functioning PanNETs, 5/78 (6%) had lymph node metastasis, 11/76 (14%) were WHO grade II, and 9/66 (14%) had microvascular invasion; 20/78 (26%) had at least one of these high-risk pathological factors. In the preoperative assessment, hetero/hypo-attenuation and MPD involvement were observed in 25/69 (36%) and 8/76 (11%), respectively. Elevated serum elastase 1 and plasma CgA levels were observed in 1/33 (3%) and 0/11 (0%) patients, respectively. On multivariate logistic regression analysis, hetero/hypo-attenuation (odds ratio [OR] 6.1, 95% confidence interval [CI] 1.7-22.2) and MPD involvement (OR 16.8, 95% CI 1.6-174.3) were significantly associated with the high-risk pathological factors. The combination of the two radiological worrisome features correctly predicted non-functioning PanNETs with high-risk pathological factors, with about 75% sensitivity, 79% specificity, and 78% accuracy. CONCLUSIONS: This combination of radiological worrisome features can accurately predict non-functioning PanNETs that may require resection.Jun. 2023, Annals of surgical oncology, 30(6) (6), 3493 - 3500, English, International magazineScientific journal
- BACKGROUND: Intracholecystic papillary neoplasm (ICPN) is one of the precursors of gallbladder cancer defined in the 2010 World Health Organization classification of tumors. We herein report ICPN with pancreaticobiliary maljunction (PBM), which is a high-risk factor for biliary cancer. CASE PRESENTATION: A 57-year-old female presented with abdominal pain. Computed tomography showed a swollen appendix and gallbladder nodules with bile duct dilatation. Endoscopic ultrasonography revealed a gallbladder tumor spreading into the cystic duct confluence accompanying PBM. Based on papillary tumors around the cystic duct detected using the SpyGlass DS II Direct Visualization System (SpyGlass DS), ICPN was suspected. We performed extended cholecystectomy, extrahepatic bile duct resection, and appendectomy with a diagnosis of ICPN and PBM. The pathological diagnosis was ICPN (90 × 50 mm) with high-grade dysplasia spreading into the common bile duct. The absence of residual cancer in the resected specimen was pathologically confirmed. P53 staining was totally negative in both the tumor and normal epithelium. The overexpression of CTNNB1 was not observed. CONCLUSIONS: We encountered a patient with a very rare gallbladder tumor, ICPN with PBM. SpyGlass DS contributed to a precise assessment of the extent of the tumor as well as a qualitative diagnosis.Jun. 2023, Clinical journal of gastroenterology, 16(3) (3), 476 - 481, English, Domestic magazineScientific journal
- Jun. 2023, Annals of surgical oncology, 30(6) (6), 3503 - 3504, English, International magazineScientific journal
- A 75-year-old Japanese woman visited a hospital with a stomachache. The patient was diagnosed with localized mild acute pancreatitis. Blood tests revealed elevated serum IgG4 levels. Contrast-enhanced computed tomography showed a hypovascular mass, 3 cm in size, in the pancreatic body with dilation of the upstream duct. Additionally, it showed another tumorous lesion of 10 mm in size in the anterior wall of the stomach, and endoscopic examination confirmed a submucosal tumor (SMT) sized 10 mm in the anterior wall of the stomach. Endoscopic ultrasound-guided fine needle aspiration biopsy (EUS-FNAB) of the pancreas revealed an adenocarcinoma concomitant with marked IgG4-positive cell infiltration. Hence, distal pancreatectomy with local gastrectomy was performed, and the final diagnosis was concluded as pancreatic ductal adenocarcinoma (PDAC) complicated by IgG4-related diseases (IgG4-RD) in the pancreas and stomach. IgG4-RD of the digestive tract is exceedingly rare. The correlation between PDAC and autoimmune pancreatitis or malignancy and IgG4-RD is controversial. However, the clinical course and histopathological examination, in this case, provide valuable suggestive findings for further discussion.May 2023, Clinical journal of gastroenterology, 16(5) (5), 785 - 790, English, Domestic magazineScientific journal
- BACKGROUND: Sarcopenia, defined as a loss of skeletal muscle mass and quality, is found in 30-65% of patients with pancreatic ductal adenocarcinoma (PDAC) at diagnosis, and is a poor prognostic factor. However, it is yet to be evaluated why sarcopenia is associated with poor prognosis. Therefore, this study elucidated the tumor characteristics of PDAC with sarcopenia, including driver gene alterations and tumor microenvironment. PATIENTS AND METHODS: We retrospectively analyzed 162 patients with PDAC who underwent pancreatic surgery between 2008 and 2017. We defined sarcopenia by measuring the skeletal muscle mass at the L3 level using preoperative computed tomography images and evaluated driver gene alteration (KRAS, TP53, CDKN2A/p16, and SMAD4) and tumor immune (CD4+, CD8+, and FOXP3+) and fibrosis status (stromal collagen). RESULTS: In localized-stage PDAC (stage ≤ IIa), overall survival (OS) and recurrence-free survival were significantly shorter in the sarcopenia group than in the non-sarcopenia group (2-year OS 89.7% versus 59.1%, P = 0.03; 2-year RFS 74.9% versus 50.0%, P = 0.02). Multivariate analysis revealed that sarcopenia was an independent poor prognostic factor in localized-stage PDAC. Additionally, tumor-infiltrating CD8+ T cells in the sarcopenia group were significantly less than in the non-sarcopenia group (P = 0.02). However, no difference was observed in driver gene alteration and fib.rotic status. These findings were not observed in advanced-stage PDAC (stage ≥ IIb). CONCLUSIONS: Sarcopenia was associated with a worse prognosis and decreased tumor-infiltrating CD8+ T cells in localized-stage PDAC. Sarcopenia may worsen a patient's prognosis by suppressing local tumor immunity.May 2023, Annals of surgical oncology, 30(9) (9), 5776 - 5787, English, International magazineScientific journal
- BACKGROUND/AIM: Recently, the Global Leadership Initiative on Malnutrition (GLIM), which includes the world's leading clinical nutrition societies, proposed the first global diagnostic criteria for malnutrition. However, the association between malnutrition diagnosed by the GLIM criteria and prognosis in patients with resected extrahepatic cholangiocarcinoma (ECC) remains unknown. This study aimed to investigate the predictive validity of the GLIM criteria for the prognosis of patients with resected ECC. PATIENTS AND METHODS: Between 2000 and 2020, 166 patients who underwent curative-intent resection for ECC were retrospectively analyzed. Prognostic significance of preoperative malnutrition diagnosed by the GLIM criteria was investigated using a multivariate Cox proportional hazards model. RESULTS: Eighty-five (51.2%) and 46 (27.7%) patients were diagnosed with moderate and severe malnutrition, respectively. Increased malnutrition severity tended to be correlated with increased lymph node metastasis rate (p-for-trend=0.0381). The severe malnutrition group had worse 1-, 3-, and 5-year overall survival rates than the normal (without malnutrition) group (82.2% vs. 91.2%, 45.6% vs. 65.1%, 29.3% vs. 61.5%, respectively, p=0.0159). In multivariate analysis, preoperative severe malnutrition was an independent predictor for poor prognosis (hazard ratio=1.68, 95% confidence interval=1.06-2.66, p=0.0282), along with intraoperative blood loss >1,000 ml, lymph node metastasis, perineural invasion, and curability. CONCLUSION: Severe preoperative malnutrition diagnosed by the GLIM criteria was associated with poor prognosis in patients who underwent curative-intent resection for ECC.May 2023, Anticancer research, 43(5) (5), 2299 - 2308, English, International magazineScientific journal
- BACKGROUND: Post-transplantation weight control is important for long-term outcomes; however, few reports have examined postoperative weight change. This study aimed to identify perioperative factors contributing to post-transplantation weight change. METHODS: Twenty-nine patients who underwent liver transplantation between 2015 and 2019 with an overall survival of >3 years were analyzed. RESULTS: The median age, model for end-stage liver disease score, and preoperative body mass index (BMI) of the recipients were 57, 25, and 23.7, respectively. Although all but one recipient lost weight, the percentage of recipients who gained weight increased to 55% (1 month), 72% (6 months), and 83% (12 months). Among perioperative factors, recipient age ≤50 years and BMI ≤25 were identified as risk factors for weight gain within 12 months (P < .05), and patients with age ≤50 years or BMI ≤25 recipients gained weight more rapidly (P < .05). The recovery time of serum albumin level ≥4.0 mg/dL was not statistically different between the 2 groups. The weight change during the first 3 years after discharge was represented by an approximately straight line, with 18 and 11 recipients showing a positive and negative slope, respectively. Body mass index ≤23 was identified as a risk factor for a positive slope of weight gain (P <.05). CONCLUSIONS: Although postoperative weight gain implies recovery after transplantation, recipients with a lower preoperative BMI should strictly manage body weight as they may be at higher risk of rapid weight increase.Apr. 2023, Transplantation proceedings, 55(4) (4), 924 - 929, English, International magazineScientific journal
- To assess the value of nonenhancing capsule by adding to enhancing capsule in gadoxetic acid-enhanced MRI (EOB-MRI) in comparison with contrast-enhanced CT (CE-CT) for diagnosing histological capsule in hepatocellular carcinoma (HCC). One-hundred fifty-one patients with HCC who underwent both CE-CT and EOB-MRI were retrospectively reviewed. Liver Imaging-Reporting and Data System (LI-RADS) v2018 imaging features, including enhancing and nonenhancing capsule were evaluated by two readers in CE-CT and EOB-MRI. Frequencies of each imaging feature were compared between CE-CT and EOB-MRI. The area under the receiver operating characteristic (AUC) curve for the diagnosis of histological capsule was compared across the following three imaging criteria: (1) enhancing capsule in CE-CT, (2) enhancing capsule in EOB-MRI, and (3) enhancing/nonenhancing capsule in EOB-MRI. Enhancing capsule in EOB-MRI was significantly less frequently depicted than that in CE-CT (p < 0.001 and = 0.016 for reader 1 and 2). Enhancing/nonenhancing capsule in EOB-MRI achieved a similar frequency of enhancing in CE-CT (p = 0.590 and 0.465 for reader 1 and 2). Adding nonenhancing capsule to enhancing capsule in EOB-MRI significantly increased AUCs (p < 0.001 for both readers) and achieved similar AUCs compared with enhancing capsule in CE-CT (p = 0.470 and 0.666 for reader 1 and 2). Adding nonenhancing capsule to the definition of capsule appearance can improve the diagnosis of capsule in EOB-MRI for the diagnosis of histological capsule in HCC and decrease discordance of capsule appearance between EOB-MRI and CE-CT.Apr. 2023, Scientific reports, 13(1) (1), 6113 - 6113, English, International magazineScientific journal
- BACKGROUND/AIM: Lenvatinib is a multiple-tyrosine kinase inhibitor used to treat hepatocellular carcinoma (HCC), and its systematic concentration varies according to liver function. The albumin-bilirubin (ALBI) grade is a novel indicator for predicting liver function in patients with hepatic disease. This study aimed to investigate the relationship between ALBI grade and HCC patients' lenvatinib treatment duration. PATIENTS AND METHODS: This is a retrospective cohort study of patients with HCC and Child-Pugh A treated with lenvatinib between April 2018 and December 2019. The baseline liver function was determined using the ALBI grade. The primary outcome was discontinuation owing to adverse events. The risk factors for discontinuation owing to adverse effects were analyzed using logistic regression. RESULTS: This investigation included 48 HCC patients. Patients with ALBI grade 2 had a significantly shorter time of discontinuation due to adverse events than those with grade 1 (p=0.036). However, the time of treatment failure did not differ between the groups. Multiple logistic regression analysis showed that ALBI grade 2 and non-use of antihypertensive drugs were independent factors for discontinuation due to adverse events [odds ratio (OR)=14.1, 95% confidence interval (CI)=1.46-135, p=0.022 and OR=5.48, 95% CI=1.13-23.9, p=0.024, respectively]. CONCLUSION: The ALBI grades may be useful in predicting adverse events caused by lenvatinib in patients with HCC and Child-Pugh A.Mar. 2023, Anticancer research, 43(3) (3), 1317 - 1323, English, International magazineScientific journal
- BACKGROUND/AIM: The chemotherapeutic landscape for hepatocellular carcinomas (HCCs) has changed dramatically with the availability of several treatment options. This study aimed to assess the long-term outcomes of lenvatinib treatment and analyze its feasibility in the sequential treatment of HCCs. PATIENTS AND METHODS: Eighty-five consecutive patients who received lenvatinib for unresectable HCCs were investigated retrospectively. Survival was assessed based on when the patients were first radiologically diagnosed with progressive disease. Among those with radiologically diagnosed stable or progressive disease at 3 months after lenvatinib administration, the cutoff α-fetoprotein (AFP) ratio (ratio of the AFP level after lenvatinib treatment to the pretreatment AFP level) that was predictive of survival was determined using receiver operating characteristic analysis. RESULTS: The median survival time (MST) was significantly worse among patients diagnosed with progressive disease at 1 month after treatment than among those diagnosed at 2-3 or 3-4 months after treatment [MSTs at 1, 2-3, and 3-4 months: 2.2, 10.2, and 17.3 months, respectively (p<0.001)]. An AFP ratio of 1.36 (computed using the AFP level at 3 months after lenvatinib treatment) was significantly predictive of survival in patients with stable or progressive disease (26.3 vs. 11.3 months, p=0.0024). CONCLUSION: The prognosis of patients on lenvatinib who develop early progressive disease is dismal. Thus, their treatment should be ceased or switched. The 3-month AFP ratio of 1.36 may be a potentially useful cutoff for considering a switch to other treatments in patients radiologically diagnosed with stable or progressive disease.Feb. 2023, Anticancer research, 43(2) (2), 911 - 918, English, International magazineScientific journal
- Hepatocellular carcinoma (HCC) is the most prevalent malignant liver neoplasm. Despite the advances in diagnosis and treatment, the prognosis of HCC patients remains poor. Cytoskeleton-associated membrane protein 4 (CKAP4) is a receptor of the glycosylated secretory protein Dickkopf-1 (DKK1), and the DKK1-CKAP4 axis is activated in pancreatic, lung, and esophageal cancer cells. DKK1 and CKAP4 expression have been examined in HCC in independent studies that yielded contradictory results. In this study, the relationship between the DKK1-CKAP4 axis and HCC was comprehensively examined. In 412 HCC cases, patients whose tumors were positive for both DKK1 and CKAP4 had a poor prognosis compared to those who were positive for only one of these markers or negative for both. Deletion of either DKK1 or CKAP4 inhibited HCC cell growth. In contrast to wild-type DKK1, DKK1 lacking the CKAP4 binding region did not rescue the phenotypes caused by DKK1 depletion, suggesting that binding of DKK1 to CKAP4 is required for HCC cell proliferation. Anti-CKAP4 antibody inhibited HCC growth, and its antitumor effect was clearly enhanced when combined with lenvatinib, a multi-kinase inhibitor. These results indicate that simultaneous expression of DKK1 and CKAP4 is involved in the aggressiveness of HCC, and that the combination of anti-CKAP4 antibody and other therapeutics including lenvatinib may represent a promising strategy for treating advanced HCC.Jan. 2023, Cancer science, English, International magazineScientific journal
- BACKGROUND: Tertiary lymphoid structure (TLS) reflects an intense immune response against cancer, which correlates with favorable patient survival. However, the association of TLS with tumor-infiltrating lymphocytes (TILs) and clinical outcomes has not been investigated comprehensively in pancreatic ductal adenocarcinoma (PDAC). METHODS: We utilized an integrative molecular pathological epidemiology database on 162 cases with resected PDAC, and examined TLS in relation to levels of TILs, patient survival, and treatment response. In whole-section slides, we assessed the formation of TLS and conducted immunohistochemistry for tumor-infiltrating T cells (CD4, CD8, CD45RO, and FOXP3). As confounding factors, we assessed alterations of four main driver genes (KRAS, TP53, CDKN2A [p16], and SMAD4) using next-generation sequencing and immunohistochemistry, and tumor CD274 (PD-L1) expression assessed by immunohistochemistry. RESULTS: TLSs were found in 112 patients with PDAC (69.1%). TLS was associated with high levels of CD4+ TILs (multivariable odds ratio [OR], 3.50; 95% confidence interval [CI] 1.65-7.80; P = 0.0002), CD8+ TILs (multivariable OR, 11.0; 95% CI 4.57-29.7, P < 0.0001) and CD45RO+ TILs (multivariable OR, 2.65; 95% CI 1.25-5.80, P = 0.01), but not with levels of FOXP3+ TILs. TLS was associated with longer pancreatic cancer-specific survival (multivariable hazard ratio, 0.37; 95% CI 0.25-0.56, P < 0.0001) and favorable outcomes of adjuvant S-1-treatment. TLS was not associated with driver gene alterations but tumor CD274 negative expression. CONCLUSIONS: Our comprehensive data supports the surrogacy of TLS for vigorous anti-tumor immune response characterized by high levels of helper and cytotoxic T cells and their prognostic role.Jan. 2023, Journal of gastroenterology, English, Domestic magazineScientific journal
- Successful Management of Refractory Autoimmune Hemolytic Anemia with Cold Agglutinin Disease with Splenectomy: A Case Report with Review of Literature.BACKGROUND: Cold agglutinin disease (CAD) is a rare autoimmune hemolytic anemia characterized by agglutination of red blood cells at temperatures below the normal core body temperature. In patients with CAD, splenectomy is not indicated because of its low therapeutic effect on hemolytic anemia induced by extravascular hemolysis. Herein, we report a case of refractory hemolytic anemia with CAD successfully managed with splenectomy. CLINICAL CASE: A 60-year-old man visited a municipal hospital with the chief complaint of fatigue. He was found to have hemolytic anemia and icterus with increased cold agglutination and was diagnosed with CAD. Malignant lymphoma was suspected as the underlying disease; however, no clear underlying disease was identified. Hemolytic anemia progressed during the subsequent winter seasons, and he was treated with temperature control, warming, and weekly blood transfusions. However, despite the blood transfusions, his hemoglobin level did not improve during the summer 2 years after diagnosis, and his previously observed splenomegaly had progressed. He was referred to our department, and a splenectomy was performed to diagnose any occult malignant lymphoma and improve the refractory hemolytic anemia. Because histopathological examination revealed no evidence of malignant lymphoma, a diagnosis of primary CAD was made. The hemolytic anemia improved, and no blood transfusion was required after splenectomy. CONCLUSIONS: Splenectomy significantly improved the patient's refractory hemolytic anemia due to primary CAD. Thus, it may be an effective treatment option in such cases, although further cases and studies are required to evaluate the effects of splenectomy.Jan. 2023, The Kobe journal of medical sciences, 68(1) (1), E30-E34, English, Domestic magazineScientific journal
- BACKGROUND: Bile leakage is a major complication after liver transplantation and remains as a significant source of morbidity and mortality. In 2011, the International Study Group of Liver Surgery (ISGLS) defined bile leakage as a drain/serum bilirubin ratio ≥3. However, to our knowledge there is no literature assessing serum and drain bilirubin concentrations after liver transplantation. The aim of this study was to describe the natural postoperative changes in serum and drain fluid bilirubin concentrations in patients after liver transplantation. METHODS: We included 32 patients who underwent liver transplantation at Kobe University Hospital from January 2007 to December 2020. We enrolled 34 living donors who had no complications as the control group. RESULTS: The recipient serum total/direct bilirubin concentration were higher compared with the donors from postoperative day (POD) 1 to 5 with a statistical difference (P < .05). The recipient drain/serum total bilirubin ratio was lower than donors on POD 3 (0.89 ± 0.07 vs 1.53 ± 0.07: P < .0001), which was also confirmed by the recipient drain/serum direct bilirubin ratio (0.64 ± 0.10 vs 1.18 ± 0.09: P < .0001). On POD 3, the drain fluid volume (647.38 ± 89.47 vs 113.43 ± 86.8 mL: P < .001) and serum total bilirubin concentration (6.73 ± 0.61 vs 1.23 ± 0.60 mg/dL: P < .001) was higher in the recipients than in donors. Categorized in 2 groups, the higher drain fluid volume and bilirubin concentration recipients showed lower drain/serum total bilirubin ratio compared with the other group (P = .03) CONCLUSION: The drain/serum bilirubin ratio in the transplanted patients could be calculated lower compared with the hepatectomy patients because of high drain fluid volume and hyperbilirubinemia. Great care should be taken when assessing the bile leakage in liver transplant recipients using the ISGLS definition.Jan. 2023, Transplantation proceedings, English, International magazineScientific journal
- BACKGROUND: Curative treatment for hepatocellular carcinoma (HCC) is limited to hepatic resection (HR), radiofrequency ablation, and liver transplantation, while the value of particle therapy (PT) as an initial treatment remains unclear. This study aimed to compare the outcomes of HR and PT for single HCC. STUDY DESIGN: A total of 554 patients with single HCC without vascular invasion were enrolled from January 2000 to December 2015. Patients underwent either HR (n = 279) or PT (n = 275) as initial treatments. A one-to-one propensity score matching (PSM) analysis was performed to evaluate the overall survival (OS) and progression-free survival (PFS) after dividing patients according to liver function as assessed by the modified albumin-bilirubin (mALBI) grade. RESULTS: The median OS (130 vs. 85 month, p = 0.001) and PFS (47 vs. 30 month, p = 0.004) of HR were also significantly better than that of PT in the PSM cohort with mALBI grade 1/2a (n = 145 per group). Meanwhile, in a PSM cohort with mALBI grade 2b/3 (n = 53 per group), there were no significant differences in median OS and PFS between HR and PT. CONCLUSION: HR may be preferable as an initial treatment for patients with single HCC without vascular invasion, especially those with preserved liver function. PT can be an acceptable alternative to HR for patients without surgical indication and/or impaired liver function.Dec. 2022, Journal of the American College of Surgeons, English, International magazineScientific journal
- Right-sided ligamentum teres (RSLT) is a rare congenital anomaly in which the fetal umbilical vein is connected to the right paramedian trunk of the portal vein. An 80-year-old woman underwent curative sigmoidectomy for sigmoid cancer 3 years prior to presentation. After 1 year, small solitary liver metastasis was noted in segment 4. Because the patient experienced recurrence of the same lesion after chemotherapy and radiofrequency ablation, she was referred to our hospital. CT revealed an anomaly of the liver with RSLT, classified as an independent posterior branch type. The tumor in the left paramedian section was located in the right umbilical portion (RUP), and BDTT was advanced to the common bile duct. Because the estimated future remnant liver volume was 35.2%, transileocecal portal vein embolization (PVE) for the portal branches from the RUP increased it to 43.5% in 3 weeks. Left trisectionectomy with extrahepatic bile duct resection and hepaticojejunostomy were performed. The patient was discharged on postoperative day 75. We successfully performed a left trisectionectomy after PVE in a patient with RSLT. Understanding the vascular and biliary anomalies of patients with RSLT is essential. When the future remnant liver is small, PVE can be considered for safe hepatectomy.Dec. 2022, Clinical journal of gastroenterology, 15(6) (6), 1130 - 1135, English, Domestic magazineScientific journal
- Dec. 2022, Asian journal of psychiatry, 78, 103282 - 103282, English, International magazine
- INTRODUCTION: With the aging of the population in Japan, gallbladder cancer (GBC) in the elderly is increasing. However, the available clinical data are limited, and the optimal treatment is still controversial. The aim of this study was to evaluate the benefit of surgical resection in GBC patients ≥75 years of age. METHODS: A retrospective single center analysis of patients who had undergone surgical resection for GBC between 2000 and 2019 was carried out. Patients aged ≥75 years (elderly group, n = 24) or <75 years (younger group, n = 50) were compared. RESULTS: Both younger and elderly patients exhibited similar clinicopathological characteristics, but comorbidity in the latter was significantly greater, as was the frequency of less invasive surgery. Nonetheless, the incidence of postoperative complications was similar in elderly and younger patients. The proportion of patients receiving adjuvant chemotherapy was lower in the elderly. Overall survival of elderly and younger patients was not significantly different (65.0 vs 62.4% at 5 years, P = .600). In multivariate analysis, residual tumor status but not age was an independent prognostic factor. DISCUSSION: This study demonstrated that appropriate surgical treatment of elderly GBC patients was safe and effective, despite their having more comorbidities and lower rates of adjuvant chemotherapy than younger patients.Nov. 2022, The American surgeon, 31348221136570 - 31348221136570, English, International magazineScientific journal
- (株)医薬情報研究所, Nov. 2022, 新薬と臨牀, 71(11) (11), 1234 - 1234, Japanese
- (株)医薬情報研究所, Nov. 2022, 新薬と臨牀, 71(11) (11), 1234 - 1234, Japanese進行肝細胞癌におけるconversion surgeryの妥当性
- 医学図書出版(株), Nov. 2022, 胆と膵, 43(11) (11), 1589 - 1592, Japanese【膵・胆管合流異常-先天性胆道拡張症の最新トピックス-】術後遺残胆管癌の診断と治療
- BACKGROUND: Anatomic liver resection (ALR) has been established to eliminate the tumor-bearing hepatic region with preservation of the remnant liver volume for liver malignancies. Recently, laparoscopic ALR has been widely applied; however, there are few reports on laparoscopic segmentectomy 2. This study aimed to present the standardization of laparoscopic segmentectomy 2 with surgical outcomes. METHODS: This study included seven patients who underwent pure laparoscopic segmentectomy 2 by the Glissonean approach from January 2020 to December 2021. Four of them had hepatocellular carcinoma, two had colorectal liver metastasis, and one had hepatic angiomyolipoma, which was preoperatively diagnosed with hepatocellular carcinoma. In all patients, preoperative three-dimensional (3D) simulation images from dynamic CT were reconstructed using a 3D workstation. The layer between the hepatic parenchyma and the Glissonean pedicle of segment 2 (G2) was dissected to encircle the root of G2. After clamping or ligation of the G2, 2.5 mg of indocyanine green was injected intravenously to identify the boundaries between segments 2 and 3 with a negative staining method under near-infrared light. Parenchymal transection was performed from the caudal side to the cranial side according to the demarcation on the liver surface, and the left hepatic vein was exposed on the cut surface if possible. RESULTS: The mean operative time for all patients was 281 min. The mean blood loss was 37 mL, and no transfusion was necessary. Estimated liver resection volumes significantly correlated with actual liver resection volumes (r = 0.61, P = 0.035). After the operation, one patient presented with asymptomatic deep venous and pulmonary thrombosis, which was treated with anticoagulant therapy. The mean length of hospital stay was 8.9 days. CONCLUSION: Laparoscopic segmentectomy 2 by the Glissonean approach is a feasible and safe procedure with the preservation of the nontumor-bearing segment 3 for liver tumors in segment 2.Nov. 2022, Surgical endoscopy, 36(11) (11), 8600 - 8606, English, International magazineScientific journal
- BACKGROUND/AIM: Atezolizumab plus bevacizumab and lenvatinib are the key drugs in the current systemic chemotherapeutic regimen for hepatocellular carcinoma (HCC). Studies have reported the potential effectiveness of lenvatinib introduction after an atezolizumab plus bevacizumab treatment; however, the therapeutic effectiveness of a lenvatinib rechallenge after an atezolizumab plus bevacizumab treatment remains unclear. PATIENTS AND METHODS: Thirteen consecutive patients who were rechallenged with lenvatinib after clinical failure following treatments with lenvatinib and atezolizumab plus bevacizumab were included. A comparative study was conducted on the duration and treatment efficacy of the first and second lenvatinib treatments and on the pre- and post-treatment liver function. RESULTS: The median ratios of the 1-month post-treatment alpha-fetoprotein (AFP) levels to the pretreatment AFP levels were 0.750 and 0.667 for the first and second lenvatinib treatments, respectively, without significant difference (p=0.9327). Meanwhile, the median ratios of the 1-month post-treatment albumin-bilirubin (ALBI) scores to the pretreatment ALBI scores were 1.063 and 0.827 for the first and second lenvatinib treatments, respectively, with significant difference (p=0.015). The median duration of the second lenvatinib treatment was significantly shorter than that of the first lenvatinib treatment [2.8 months (range=0.9-4.7 months) vs. 8.7 months (range=3.1-29.7 months)]. CONCLUSION: Lenvatinib re-administration after atezolizumab plus bevacizumab treatment can act as a double-edged sword, as it exerts an anti-tumor effect while being associated with potential liver function deterioration. However, this treatment sequence can be useful, and requires careful monitoring of the transitions in the liver function and the patient's performance status.Nov. 2022, Anticancer research, 42(11) (11), 5479 - 5486, English, International magazineScientific journal
- BACKGROUND AND AIM: Endoscopic ultrasonography (EUS) findings of the pancreatic parenchyma, such as hyperechoic foci/stranding and lobularity, may be associated with the severity of chronic pancreatitis (CP). However, the correlation between parenchymal EUS findings and histology remains unclear. We designed a large-scale retrospective study analyzing over 200 surgical specimens to elucidate the association between parenchymal EUS findings and histological features. METHODS: Clinical data of 221 patients with pancreatobiliary tumors who underwent preoperative EUS and pancreatic surgery between January 2010 and November 2020 were reviewed to investigate the association between parenchymal EUS findings and histological features at the pancreatic body. None of these patients met the definition of CP. RESULTS: Of the 221 patients, 87 (39.4%), 89 (40.2%), and 45 (20.4%) had normal EUS findings, hyperechoic foci/stranding without lobularity, and hyperechoic foci/stranding with lobularity, respectively. In the multivariate analyses, parenchymal EUS findings significantly correlated with histological CP findings of fibrosis, inflammation, and atrophy (hyperechoic foci/stranding without lobularity vs hyperechoic foci/stranding with lobularity, odds ratio [95% confidence interval]: 4.1 [2.2-7.9] vs 31.3 [9.3-105.6], Ptrend < 0.001; 3.9 [1.9-8.2] vs 21.8 [8.0-59.4], Ptrend < 0.001; and 4.0 [2.0-7.8] vs 22.9 [7.0-74.5], Ptrend < 0.001, respectively). Further, a trend toward higher histological grade was observed in the following order: normal findings, hyperechoic foci/stranding without lobularity, and hyperechoic foci/stranding with lobularity. CONCLUSIONS: Endoscopic ultrasonography findings of the pancreatic parenchyma may be associated with the histological conditions in CP, such as pancreatic fibrosis, inflammation, and atrophy. Lobularity reflects more severe histological conditions than does hyperechoic foci/stranding.Oct. 2022, Journal of gastroenterology and hepatology, 38(1) (1), 103 - 111, English, International magazineScientific journal
- Oct. 2022, Annals of surgical oncology, 30(1) (1), 383 - 383, English, International magazineScientific journal
- BACKGROUND: Laparoscopic caudate lobe resection is a challenging procedure. Several researchers have reported the safety of laparoscopic liver resections;1.Transl Gastroenterol Hepatol. 1:56;2.Asian J Endosc Surg. 12:232-236;3.Ann Surg Oncol. 26:2980; however, a standardized procedure has not yet been established. Herein, we present a video showing laparoscopic Spiegel lobectomy in a patient with 6-cm hepatocellular carcinoma (HCC) using a novel approach. PATIENT AND METHODS: A 63-year-old man with a caudate lobe HCC was referred to our hospital. Computed tomography showed a 5 × 6 cm2 HCC located in the Spiegel lobe, which profoundly displaced the inferior vena cava (IVC) to the lower right side, and mobilization of the Spiegel lobe was considered difficult. To perform the dissection between the Siegel lobe and IVC safely, we performed parenchymal transection along the ventral side of the IVC initially. The Spiegel lobe was then dislocated to the left side of the IVC. We dissected the left lateral side of the IVC, including the proper hepatic vein draining the caudate lobe and the left IVC ligament with a safe operative field, and successfully removed the Spiegel lobe with large HCC. RESULTS: The operation time was 383 min. The blood loss was 10 mL. The patient was discharged on the seventh postoperative day without any complications. Histopathological examination revealed well-differentiated HCC with a negative surgical margin. CONCLUSIONS: Laparoscopic medial-to-lateral approach with initial parenchymal transection at the medial side of the Spiegel lobe followed by dissection of the left lateral side of the IVC is considered as a safe and effective procedure for large tumors in the Spiegel lobe.Oct. 2022, Annals of surgical oncology, 30(1) (1), 381 - 382, English, International magazineScientific journal
- AIM: Although Makuuchi's criteria are widely used to determine the cut-off for safe liver resection, there have been few reports of concrete data supporting their validity. Here, we verified the utility of Makuuchi's criteria by comparing the operative mortality rates associated with liver resection between hepatocellular carcinoma (HCC) patients meeting or exceeding the criteria. METHODS: A database was built using data from 15 597 patients treated between 2000 and 2007 for whom values for all three variables included in Makuuchi's criteria for liver resection (clinical ascites, serum bilirubin, and indocyanine green clearance) were available. The patients were divided into those fulfilling (n = 12 175) or exceeding (n = 3422) the criteria. The postoperative mortality (death for any reason within 30 days) and long-term survival were compared between the two groups. RESULTS: The operative mortality rate was significantly lower in patients meeting the criteria than in those exceeding the criteria (1.07% vs. 2.01%, respectively; p < 0.001). On multivariate analysis, exceeded the criteria was significantly associated with the risk for operative mortality (relative risk 2.08; 95% confidence interval (CI), 1.23-3.52; p = 0.007). Surgical indication meeting or exceeding the criteria was an independent factor for overall survival (hazard ratio 1.27; 95% CI, 1.18-1.36; p < 0.001). CONCLUSION: Makuuchi's criteria are suitable for determining the indication for resection of HCC due to the reduction in risk of operative mortality.Oct. 2022, Hepatology research : the official journal of the Japan Society of Hepatology, 53(2) (2), 127 - 134, English, International magazineScientific journal
- Sep. 2022, Surgery today, 53(1) (1), 158 - 158, English, Domestic magazine
- Endoscopic papillectomy for early ampullary tumors is considered a minimally invasive and useful alternative to pancreatoduodenectomy; however, its indications remain unclear. This study aimed to clarify the advantages of endoscopic papillectomy by investigating the clinical outcomes of patients who underwent endoscopic papillectomy or pancreatoduodenectomy for early ampullary tumors. Patients diagnosed with early ampullary tumors (adenoma, Tis, T1a) who underwent endoscopic papillectomy or pancreatoduodenectomy between June 2008 and October 2019 were included, and their clinical outcomes were analyzed. Seventy-four patients (34 patients with adenomas and 40 patients with adenocarcinomas) were divided into two groups, namely endoscopic papillectomy (n = 43) and pancreatoduodenectomy (n = 31). The estimated 5-year overall survival rate of all early ampullary tumors was 92%. Complete resection rate was significantly lower for endoscopic papillectomy patients versus pancreatoduodenectomy patients (48.8% vs. 100%; p < 0.001). Recurrence was more common in the endoscopic papillectomy group compared to the pancreatoduodenectomy group (16.3% vs. 3.2%; p = 0.128), but all recurrences were controllable by endoscopic treatment. The median length of hospital stay for the endoscopic papillectomy group was significantly shorter compared to the endoscopic papillectomy group (11 days vs. 42 days; p < 0.001). The Comprehensive Complication Index was significantly lower in the endoscopic papillectomy group compared to the pancreatoduodenectomy group (14.8 vs 22.6%; p = 0.002). Endoscopic papillectomy for early ampullary tumors is useful and may be an alternative treatment for pancreatoduodenectomy in selected cases.Sep. 2022, Scientific reports, 12(1) (1), 15134 - 15134, English, International magazineScientific journal
- (株)東京医学社, Sep. 2022, 小児外科, 54(9) (9), 877 - 879, Japanese
- AIM: Sorafenib was previously considered a first-line treatment for hepatocellular carcinoma (HCC) patients with macroscopic portal vein tumor thrombus (PVTT). This case-matched analysis was performed to evaluate the best first-line treatment for HCC in patients with macroscopic PVTT. METHODS: The HCC patients with Vp2 (PVTT invaded into a second-order portal branch), Vp3 (first-order portal branch), and Vp4 (main trunk or contralateral portal vein) PVTT who underwent hepatectomy and those treated with sorafenib were included. Treatment results were compared between the two modalities for each PVTT category, and a propensity analysis was performed for patients with Vp3 and Vp4 (Vp3/4). RESULTS: The median survival times (MSTs) of patients with Vp2, Vp3, and Vp4 PVTT who underwent hepatectomy were 21.4, 13.6, and 14.9 months, respectively; the MSTs for those with Vp2, Vp3, and Vp4 PVTT who received sorafenib treatment were 6.9, 5.5, and 3.6 months, respectively, with a significant difference. In a propensity-matched cohort of patients with Vp3/4 PVTT (36 patients in each), the MST of patients who underwent hepatectomy (15.1 months) was significantly better than the patients treated with sorafenib (4.5 months). CONCLUSION: Hepatectomy can be associated with prolonged survival in HCC patients with macroscopic PVTT.Sep. 2022, Journal of hepato-biliary-pancreatic sciences, English, Domestic magazineScientific journal
- Stapling is the standard method for pancreatic transection during laparoscopic distal pancreatectomy. Although most surgeons use a 60 mm cartridge stapler, space limitations created by laparoscopic surgery make the instrument difficult to handle, especially during pancreatic transection at the neck. Therefore, we currently use a 45 mm cartridge stapler for laparoscopic pancreatic transection at the neck. Between October 2019 and December 2020, we performed pancreatic transection using a 45 mm cartridge stapler in 27 patients. Fifteen patients experienced biochemical leakage, but no patients developed clinically relevant pancreatic fistula. The compactness of the 45 mm cartridge has several benefits: (1) less space is required for flexing, opening, and closing the device; (2) it enables easy insertion of the lower jaw behind the pancreas, even if the dissected space behind the pancreas is narrow; (3) less obstruction of the surgeons' view prevents accidental injury to the surrounding tissues and vessels. These benefits may enable safe pancreatic transection.Jul. 2022, Surgery today, 53(1) (1), 153 - 157, English, Domestic magazineScientific journal
- Breast cancer is the most frequent malignancy in women worldwide. Basal-like breast cancer (BLBC) is the most aggressive form of this disease, and patients have a poor prognosis. Here, we present data suggesting that the Hippo-transcriptional coactivator with PDZ-binding motif (TAZ) pathway is a key driver of BLBC onset and progression. Deletion of Mob1a/b in mouse mammary luminal epithelium induced rapid and highly reproducible mammary tumorigenesis that was dependent on TAZ but not yes-associated protein 1 (YAP1). In situ early-stage BLBC-like malignancies developed in mutant animals by 2 wk of age, and invasive BLBC appeared by 4 wk. In a human estrogen receptor+ luminal breast cancer cell line, TAZ hyperactivation skewed the features of these luminal cells to the basal phenotype, consistent with the aberrant TAZ activation frequently observed in human precancerous BLBC lesions. TP53 mutation is rare in human precancerous BLBC but frequent in invasive BLBC. Addition of Trp53 deficiency to our Mob1a/b-deficient mouse model enhanced tumor grade and accelerated cancer progression. Our work justifies targeting the Hippo-TAZ pathway as a therapy for human BLBC, and our mouse model represents a powerful tool for evaluating candidate agents.Jul. 2022, Proceedings of the National Academy of Sciences of the United States of America, 119(29) (29), e2123134119, English, International magazine, Co-authored internationallyScientific journal
- Portal vein thrombosis (PVT) is a lethal complication of hepatectomy if not properly treated. An 81-year-old woman diagnosed with postoperative PVT after right hepatectomy and caudate lobectomy for perihilar cholangiocarcinoma. Elevation of serum total bilirubin levels, D-dimer levels, and glossy ascites appeared on postoperative day 5 (POD5), and a contrast-enhanced CT confirmed PVT. Thrombi were found from the umbilical portion of the portal vein to the superior mesenteric vein. There were signs of acute liver failure due to thrombi obstructing the portal vein. Therefore, emergent catheter thrombus aspiration was performed under laparotomy. An aspiration catheter was inserted into the superior mesenteric vein from the ileocolic vein. We performed direct aspiration thrombectomy, followed by anticoagulant administration using urokinase via the catheter. Partial recanalization of the portal vein and superior mesenteric vein was observed. To dissolve residual thrombi, edoxaban administration was started on POD6. Contrast-enhanced CT 16 days after her additional operation showed the thrombi had completely disappeared. The patient was discharged on POD76. She had no recurrence of PVT over the next 6 months. Combination therapy of early intervention using aspiration catheter and systemic anticoagulant medication was useful for severe postoperative PVT accompanied with liver failure.Jun. 2022, Clinical journal of gastroenterology, 15(5) (5), 981 - 987, English, Domestic magazineScientific journal
- Jun. 2022, Journal of hepato-biliary-pancreatic sciences, English, Domestic magazine
- This study aimed to retrospectively analyze the clinical outcomes of patients with pelvic and retroperitoneal bone and soft tissue sarcoma (BSTS). Overall, 187 patients with BSTS in the pelvis and retroperitoneal region treated at 19 specialized sarcoma centers in Japan were included. The prognostic factors related to overall survival (OS), local control (LC), and progression-free survival (PFS) were evaluated. The 3-year OS and LC rates in the 187 patients were 71.7% and 79.1%, respectively. The 3-year PFS in 166 patients without any distant metastases at the time of primary tumor diagnosis was 48.6%. Osteosarcoma showed significantly worse OS and PFS than other sarcomas of the pelvis and retroperitoneum. In the univariate analyses, larger primary tumor size, soft tissue tumor, distant metastasis at the time of primary tumor diagnosis, P2 location, chemotherapy, and osteosarcoma were poor prognostic factors correlated with OS. Larger primary tumor size, higher age, soft tissue tumor, chemotherapy, and osteosarcoma were poor prognostic factors correlated with PFS in patients without any metastasis at the initial presentation. Larger primary tumor size was the only poor prognostic factor correlation with LC. This study has clarified the epidemiology and prognosis of patients with pelvic and retroperitoneal BSTS in Japan.Jun. 2022, Cancers, 14(12) (12), English, International magazineScientific journal
- BACKGROUND: Resecting liver tumors located in Couinaud's segment VII is challenging; the efficacy and safety of laparoscopic liver resection for segment VII lesions compared to open liver resection remain unclear. METHODS: Medical records of 84 patients who underwent liver resection of segment VII at Kobe University Hospital and Hyogo Cancer Center between 2010 and 2021 were retrospectively analyzed. Surgical outcomes were compared between laparoscopic liver resection and open liver resection groups using propensity matching analysis. RESULTS: Thirty-one and 53 patients underwent laparoscopic liver resection and open liver resection, respectively. After propensity matching, 29 patients were included in each group. The laparoscopic liver resection group had a significantly longer operation time (407 vs. 305 min, P = 0.002), lower blood loss (100 vs. 230 mL, P = 0.004), and higher postoperative alanine aminotransferase levels (436 vs. 252 IU/L, P = 0.008) than the open liver resection group. In patients with liver cirrhosis, the proportion of patients with postoperative liver-specific complications was higher in the laparoscopic liver resection group than in the open liver resection group (57% vs 11%, P = 0.049), although there was no significant difference in postoperative liver-specific complication rates between the groups in patients without liver cirrhosis. CONCLUSIONS: For liver resection of segment VII, laparoscopic liver resection led to higher postoperative liver damage than open liver resection. Open liver resection may be better for patients with liver cirrhosis to avoid postoperative liver-specific complications. Laparoscopic liver resection could be an acceptable procedure for patients without liver cirrhosis, with some merits such as less blood loss.Jun. 2022, Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 26(11) (11), 2274 - 2281, English, International magazineScientific journal
- Enteroendocrine cells (EECs) are the primary sensory cells that sense the gut luminal environment and secret hormones to regulate organ function. Recent studies revealed that vagal afferent neurons are connected to EECs and relay sensory information from EECs to the brain stem. To date, however, the identity of vagal afferent neurons connected to a given EEC subtype and the mode of their gene responses to its intestinal hormone have remained unknown. Hypothesizing that EEC-associated vagal afferent neurons change their gene expression in response to the microbiota-related extracellular stimuli, we conducted comparative gene expression analyses of the nodose-petrosal ganglion complex (NPG) using specific pathogen-free (SPF) and germ-free (GF) mice. We report here that the Uts2b gene, which encodes a functionally unknown neuropeptide, urotensin 2B (UTS2B), is expressed in a microbiota-dependent manner in NPG neurons. In cultured NPG neurons, expression of Uts2b was induced by AR420626, the selective agonist for FFAR3. Moreover, distinct gastrointestinal hormones exerted differential effects on Uts2b expression in NPG neurons, where cholecystokinin (CCK) significantly increased its expression. The majority of Uts2b-expressing NPG neurons expressed CCK-A, the receptor for CCK, which comprised approximately 25% of all CCK-A-expressing NPG neurons. Selective fluorescent labeling of Uts2b-expressing NPG neurons revealed a direct contact of their nerve fibers to CCK-expressing EECs. This study identifies the Uts2b as a microbiota-regulated gene, demonstrates that Uts2b-expressing vagal afferent neurons transduce sensory information from CCK-expressing EECs to the brain, and suggests potential involvement of UTS2B in a modality of CCK actions.Jun. 2022, Biochemical and biophysical research communications, 608, 66 - 72, English, International magazineScientific journal
- Objectives Small proline-rich protein 1A (SPRR1A) is recognized as a squamous differentiation marker but is also upregulated in some non-squamous cancers. However, its expression in pancreatic ductal adenocarcinoma (PDAC) has not been investigated. This study elucidated the expression of SPRR1A in PDAC and its effect on the prognosis and malignant behavior of PDAC. Methods We examined the SPRR1A expression by immunohistochemistry in 86 surgical PDAC cases and revealed the relationship between its expression and the prognosis of the PDAC patients. Furthermore, we overexpressed SPRR1A in pancreatic cancer cell lines (PK-1 and Panc-1) and assessed the phenotype and gene expression changes in vitro. Results Among the 84 cases, excluding 2 with squamous differentiation, 31 (36.9%) had a high SPRR1A expression. The overall survival (median 22.1 months vs. 33.6 months, p = 0.0357) and recurrence-free survival (median 10.7 months vs. 15.5 months, p = 0.0298) were significantly lower in the high-SPRR1A-expression group than in the low-SPRR1A-expression group. A multivariate analysis indicated that a high SPRR1A expression (HR 1.706, 95% CI 1.018 to 2.862, p = 0.0427) and residual tumor status (HR 2.687, 95% CI 1.487 to 4.855, p = 0.00106) were independent prognostic factors. The analysis of TCGA transcriptome data demonstrated that the high-SPRR1A-expression group had a significantly worse prognosis than the low-SPRR1A-expression group, which supported our data. SPRR1A overexpression in PK-1 and Panc-1 did not result in remarkable changes to in vitro phenotypes, such as the cell proliferation, chemo-resistance, EMT, migration or global gene expression. Conclusion Increased expression of SPRR1A is associated with a poor prognosis in PDAC and may serve as a novel prognostic marker. However, our in vitro study suggests that the SPRR1A expression may be a consequence, not a cause, of the aggressive behavior of PDAC.Public Library of Science (PLoS), May 2022, PLOS ONE, 17(5) (5), e0266620 - e0266620, English, International magazineScientific journal
- BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) concomitant with intraductal papillary mucinous neoplasm (IPMN) is defined as PDAC occurring apart from IPMN. This study comprehensively investigated the molecular biologic characteristics of PDAC concomitant with IPMN in major genetic alterations, tumor microenvironment, and prognosis by contrast with those of conventional PDAC. METHODS: The study retrospectively reviewed the data of 158 surgically resected PDAC patients. The driver gene alteration status (KRAS, TP53, CDKN2A, SMAD4, and GNAS) together with the immune and fibrotic status in tumor was evaluated. The prognosis of PDAC concomitant with IPMN and that of conventional PDAC also were compared. RESULTS: No statistically significant difference was found between PDAC concomitant with IPMN and conventional PDAC in the alteration frequency analysis of the major driver genes and the immune and fibrotic status in the tumor microenvironment. Overall survival and disease-free survival between patients who had PDAC concomitant with IPMN and those who had conventional PDAC did not show statistically significant differences in propensity-matched subjects. Furthermore, the co-existence of IPMN was not a poor prognostic factor in the multivariable-adjusted Cox proportional hazards model (hazard ratio, 0.95; 95 % confidence interval, 0.51-1.78). CONCLUSIONS: In this study, PDAC concomitant with IPMN had tumor characteristics similar to those of conventional PDAC in terms of the major driver gene alterations, tumor microenvironment, and prognosis.May 2022, Annals of surgical oncology, 29(8) (8), 4924 - 4934, English, International magazineScientific journal
- Mutations in IDH1/2 and the epigenetic silencing of TET2 occur in leukaemia or glioma in a mutually exclusive manner. Although intrahepatic cholangiocarcinoma (iCCA) may harbour IDH1/2 mutations, the contribution of TET2 to carcinogenesis remains unknown. In the present study, the expression and promoter methylation of TET2 were investigated in iCCA. The expression of TET2 was assessed in 52 cases of iCCA (small-duct type, n = 33; large-duct type, n = 19) by quantitative PCR, immunohistochemistry (IHC) and a sequencing-based methylation assay, and its relationships with clinicopathological features and alterations in cancer-related genes (e.g., KRAS and IDH1) were investigated. In contrast to non-neoplastic bile ducts, which were negative for TET2 on IHC, 42 cases (81%) of iCCA showed the nuclear overexpression of TET2. Based on IHC scores (area × intensity), these cases were classified as TET2-high (n = 25) and TET2-low (n = 27). The histological type, tumour size, lymph node metastasis and frequency of mutations in cancer-related genes did not significantly differ between the two groups. Overall and recurrence-free survival were significantly worse in patients with TET2-high iCCA than in those with TET2-low iCCA. A multivariate analysis identified the high expression of TET2 as an independent prognostic factor (HR = 2.94; p = 0.007). The degree of methylation at two promoter CpG sites was significantly less in TET2-high iCCA than in TET2-low iCCA or non-cancer tissue. In conclusion, in contrast to other IDH-related neoplasms, TET2 overexpression is common in iCCA of both subtypes, and its high expression, potentially induced by promoter hypomethylation, is an independent poor prognostic factor.May 2022, Virchows Archiv : an international journal of pathology, 480(5) (5), 1077 - 1085, English, International magazine, Co-authored internationallyScientific journal
- BACKGROUND: Particle therapy (PT) holds a great potential for unresectable hilar cholangiocarcinoma (HC), even though the anatomical proximity to the gastrointestinal tract prevents delivering a radical dose to the tumor. Space-making PT (SMPT), consisting of spacer placement surgery and subsequent PT, has been developed to minimize complications and maximize the therapeutic benefit of dose escalation for HC. This study aimed to examine the effectiveness of SMPT for the treatment of HC. METHODS: Between 2007 and 2018, 12 patients with unresectable HC treated with SMPT were enrolled. The treatment outcomes and effectiveness of spacer placement surgery were evaluated through analyses of pre- and post- surgical parameters of dose volume histograms. RESULTS: The median survival time was 29.6 months, and the 1- and 3-year overall survival rates were 82.5% and 45.8%, respectively. The mean V95% value (volume irradiated with 95% of the planned treatment dose) of the gross tumor volume and clinical target volume after spacer placement surgery improved to 98.5% and 96.6% from preoperative values of 85.6% and 78.1%, respectively (p = 0.0196 and p = 0.0053 respectively). Grade 3 or higher adverse events after SMPT were seen in 6 patients. CONCLUSIONS: SMPT led to improvements in dosimetric parameters and showed good feasibility and excellent outcomes. SMPT can be a promising novel alternative for unresectable HC.Apr. 2022, Digestive surgery, English, International magazineScientific journal
- BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) has a high recurrence rate even after curative resection. Lung recurrence may have better outcomes than other recurrences. However, its detailed clinicopathological features are unclear. We investigated the clinicopathological features and risk factors for lung recurrence after pancreatectomy for PDAC. METHODS: The study included 161 patients with potentially and borderline resectable PDAC who had undergone R0 or R1 pancreatectomy between January 2008 and December 2016. We retrospectively examined the prognosis and predictors for lung recurrence after curative resection. RESULTS: Seventeen patients (10.6%) had isolated lung recurrence. The median overall and recurrence-free survivals were 38.0 and 16.1 months, respectively. In multivariate analysis, para-aortic lymph node (PALN) metastasis (p = 0.006) and female sex (p = 0.027) were independent factors for lung recurrence. CONCLUSION: Lung recurrence had a better prognosis than other recurrences. PALN metastasis and female sex are independent risk factors for lung recurrence after curative resection for PDAC.Mar. 2022, Asian journal of surgery, English, International magazineScientific journal
- (一社)日本外科学会, Mar. 2022, 日本外科学会雑誌, 123(2) (2), 187 - 191, Japanese外科領域における医工連携と医療機器開発
- In the treatment of retroperitoneal sarcoma involving major vessels, complete resection with vascular reconstruction is challenging. We describe the case of a 72-year-old man who presented with 8 months of abdominal pain. Diagnostic workup revealed occlusion of the celiac trunk and the origin of the superior mesenteric artery due to a soft tissue sarcoma. Radical resection of the tumor and vessels was performed. Guided by intraoperative angiography, arterial reconstruction was performed without mesenteric ischemia. All arterial margins were negative. At the 6-year follow-up, the patient was alive with no evidence of recurrence.Mar. 2022, Journal of vascular surgery cases and innovative techniques, 8(1) (1), 70 - 74, English, International magazine
- BACKGROUND/AIM: Atezolizumab plus bevacizumab therapy is the new standard treatment option for advanced hepatocellular carcinoma (HCC). The clinical details and sequential course after atezolizumab plus bevacizumab therapy remain to be determined. PATIENTS AND METHODS: Thirty-four consecutive patients who received atezolizumab plus bevacizumab therapy were evaluated. Their clinical outcomes were assessed according to liver function classified by modified albumin-bilirubin (ALBI) grade 1 and 2a (1/2a) versus 2b and treatment line (first-line versus second- or later-line). Furthermore, the treatment sequence after atezolizumab plus bevacizumab therapy was also assessed. RESULTS: The objective response and disease control rates were 15.6% and 93.8%, respectively. The median proportions of ALBI scores at 1, 2, and 3 months relative to the baseline scores were 0.94, 0.97, and 0.93, respectively. The median proportions of α-fetoprotein (AFP) scores at 1, 2, and 3 months relative to the baseline scores were 0.98, 1.12, and 1.83, respectively. There were no significant differences in the changes in the proportions of AFP and ALBI scores according to both liver function and treatment line. Twelve patients were administered lenvatinib treatment after the failure of atezolizumab plus bevacizumab therapy. The proportions of AFP and ALBI scores at 1 month relative to the baseline scores were 0.55 and 0.81, respectively. CONCLUSION: Atezolizumab plus bevacizumab therapy can be effective for advanced HCC irrespective of the patients' liver function and treatment line. Lenvatinib administration after atezolizumab plus bevacizumab therapy can be effective, although special attention should be paid to the deterioration of liver function.Mar. 2022, Anticancer research, 42(3) (3), 1403 - 1412, English, International magazineScientific journal
- Feb. 2022, Journal of hepato-biliary-pancreatic sciences, English, Domestic magazine
- BACKGROUND: Factors associated with long-term survival in gemcitabine-concurrent proton radiotherapy (GPT) for non-metastatic, locally advanced pancreatic cancer (LAPC) remain unclear. This study aimed to determine the factors associated with long-term survival in GPT for non-metastatic LAPC. METHODS: The medical records of 123 patients with LAPC treated with GPT between February 2009 and December 2019 at Hyogo Ion Beam Medical Center were retrospectively reviewed to assess the factors associated with long-term survival outcomes. RESULTS: The median overall survival of the total cohort treated with GPT was 18.7 months. The 1- and 2-year overall, local progression-free, and progression-free survival rates were 70.4% and 35.7%, 78.2% and 59.0%, and 38.6% and 20.8%, respectively. Multivariate analysis revealed that LAPCs at the pancreatic body-tail and those without anterior peripancreatic invasion were independently associated with longer overall survival (P = 0.040 and P = 0.015, respectively). The median overall survival of patients with LAPC at the pancreatic body-tail and those with LAPC without anterior peripancreatic invasion were 24.1 and 28.1 months, respectively. LAPCs at the pancreatic body-tail had a higher volume ratio irradiated over 60 Gy equivalents at gross tumor volume than those at the pancreatic head (P < 0.001). LAPCs with anterior peripancreatic invasion had more peritoneal recurrence within 6 months after GTP than those without anterior peripancreatic invasion (P = 0.039). CONCLUSIONS: GPT is a promising treatment option for patients with LAPC at the pancreatic body-tail and those with LAPC without anterior peripancreatic invasion.Feb. 2022, Radiation oncology (London, England), 17(1) (1), 32 - 32, English, International magazineScientific journal
- INTRODUCTION: Although the relationship between systemic inflammatory responses and prognosis has been known in various cancers, it remains unclear which scores are most valuable for determining the prognosis of extrahepatic cholangiocarcinoma. We aimed to verify the usefulness of various inflammation-based scores as prognostic factors in patients with resected extrahepatic cholangiocarcinoma. METHODS: We analyzed consecutive patients undergoing surgical resection for extrahepatic cholangiocarcinoma at our institution between January 2000 and December 2019. The usefulness of the following inflammation-based scores as prognostic factor was investigated: Glasgow prognostic score (GPS), modified Glasgow prognostic score (mGPS), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), lymphocyte to monocyte ratio (LMR), prognostic nutrition index (PNI), C-reactive protein to albumin ratio (CAR), controlling nutritional status (CONUT), and prognostic index (PI). RESULTS: A total of 169 patients were enrolled in this study. Of the nine scores, CAR and CONUT indicated prognostic value. Furthermore, multivariate analysis for overall survival revealed that high CAR (>0.23) was an independent prognostic factor (HR: 1.816, 95%CI: 1.135-2.906, p=0.0129), along with lymph node metastasis and curability. There was no difference in tumor staging and short-term outcomes between the low CAR (≤ 0.23) and high CAR groups. CONCLUSIONS: CAR was the most valuable prognostic score in patients with resected extrahepatic cholangiocarcinoma.Jan. 2022, Digestive surgery, English, International magazineScientific journal
- BACKGROUND: Gadoxetic acid-enhanced magnetic resonance imaging (MRI) is useful in detecting liver metastases from pancreatic ductal adenocarcinoma (PDAC). However, the long examination time limits its utility in the initial workup of patients with PDAC. PURPOSE: To evaluate the incremental value of an abbreviated gadoxetic acid-enhanced MRI for the detection of liver metastases in patients with PDAC. STUDY TYPE: Retrospective. POPULATION: Patients (N = 130) with potentially resectable PDAC (women, 58 [44.6%]). FIELD STRENGTH/SEQUENCE: 1.5 T and 3 T; gradient dual-echo T1-weighted (in-phase and opposed-phase), fat-suppressed fast spin-echo T2-weighted, single-shot echo-planar diffusion-weighted, and three-dimensional fat-suppressed T1-weighted gradient-echo dynamic contrast-enhanced and hepatobiliary phase sequences, as well as contrast-enhanced computed tomography (CECT). ASSESSMENT: Three radiologists independently reviewed three different image sets to detect liver metastases: set 1, CECT alone; set 2, CECT and abbreviated MRI comprising fat-suppressed T2-weighted, diffusion-weighted, and hepatobiliary phase images; and set 3, CECT and standard gadoxetic acid-enhanced MRI. STATISTICAL TESTS: Figure of merit (FOM) was compared using the jackknife alternative free-response receiver operating characteristics, and other per-lesion and per-patient diagnostic parameters for each image set were compared using McNemar's and Fisher's test. P < 0.05 was considered statistically significant. RESULTS: A total of 43 liver metastases were identified in 13 patients. Reader-averaged FOM to detect liver metastases were significantly higher for sets 2 (0.884) and 3 (0.886) than for set 1 (0.609), while they were comparable between sets 2 and 3 (P = 0.96). The mean per-patient sensitivities, negative predictive values, and accuracies were significantly higher for sets 2 and 3 than for set 1, while those between sets 2 and 3 were not significantly different (not applicable, P > 0.99, and P > 0.99, respectively). DATA CONCLUSION: Gadoxetic acid-enhanced MRI combined with CECT had higher diagnostic performance than CECT alone for the detection of liver metastases in patients with PDAC. The incremental values were comparable for the abbreviated MRI and standard MRI. LEVEL OF EVIDENCE: 3 TECHNICAL EFFICACY: Stage 2.Jan. 2022, Journal of magnetic resonance imaging : JMRI, English, International magazineScientific journal
- (株)癌と化学療法社, Jan. 2022, 癌と化学療法, 49(1) (1), 80 - 82, Japanese
- BACKGROUND: Hepatocellular carcinoma (HCC) with major portal vein tumor thrombus (Vp4 PVTT) is an extremely advanced tumor with limited treatment options. Systemic chemotherapy is the only recommended treatment option, and atezolizumab plus bevacizumab has recently emerged as a first-line treatment option. CASE PRESENTATION: We describe the case of an 82-year-old man with unresectable advanced HCC with Vp4 PVTT who achieved a significant response to atezolizumab plus bevacizumab treatment. A single administration of atezolizumab plus bevacizumab ensured significant anti-tumor effects (regression in the tumor size and PVTT, portal vein recanalization, and serum alfa-fetoprotein levels decreased from 90,770 to 89 ng/mL). The patient continued with atezolizumab monotherapy, and after nine consecutive regimens, there was no apparent sign of residual tumor. CONCLUSIONS: This case demonstrates the powerful anti-tumor effect of atezolizumab plus bevacizumab treatment for advanced HCC with Vp4 PVTT, suggesting that these agents can be a promising treatment option for such refractory tumors.Dec. 2021, BMC gastroenterology, 21(1) (1), 470 - 470, English, International magazineScientific journal
- (株)癌と化学療法社, Dec. 2021, 癌と化学療法, 48(13) (13), 2008 - 2010, Japanese
- (株)癌と化学療法社, Dec. 2021, 癌と化学療法, 48(13) (13), 2011 - 2013, Japanese
- A 68-year-old man who had undergone distal gastrectomy for gastric cancer 3 years previously, presented to our hospital for examination of dilatation of the main pancreatic duct on follow-up computed tomography and magnetic resonance cholangiopancreatography. After examination, he was diagnosed with early-stage pancreatic cancer and distal pancreatectomy (DP) was planned. With informed consent, we performed indocyanine green (ICG) fluorography during DP and digital subtraction angiography (DSA) of vessels supplying the remnant stomach immediately before and after DP. On ICG fluorography, the remnant stomach gradually became fluoresced starting at the area of the lesser curvature, and the fluorescence eventually intensified over the entire area of the remnant stomach to the same brightness as that of the liver and duodenum. On DSA following DP, the terminal branches of the left inferior phrenic artery (LIPA) were distributed to more than half of the area of the remnant stomach, centering around the proximal area. It is useful to confirm blood flows to the remnant stomach by ICG fluorography using a near-infrared imaging camera during DP. We found that the LIPA played an important role in maintaining the blood supply to the remnant stomach in the absence of the left gastric artery and splenic artery.Dec. 2021, Clinical journal of gastroenterology, 14(6) (6), 1749 - 1755, English, Domestic magazineScientific journal
- BACKGROUND: Radiological detection of small liver metastasis or peritoneal metastasis is still difficult, and some patients with biliary tract cancer (BTC) are unresectable after laparotomy. Staging laparoscopy may help avoid unnecessary laparotomy. However, which category of BTC is amenable with staging laparoscopy remains unclear. AIM: To clarify the risk factors for occult metastasis in patients with BTC. METHODS: Medical records of patients with BTC who underwent surgery at our institution between January 2008 and June 2014 were retrospectively reviewed. The patients were divided into two groups, according to resection or exploratory laparotomy (EL). Preoperative laboratory data, including inflammation-based prognostic scores and tumor markers, were compared between the two groups. Prognostic importance of detected risk factors was also evaluated. RESULTS: A total of 236 patients were enrolled in this study. Twenty-six (11%) patients underwent EL. Among the EL patients, there were 16 cases of occult metastasis (7 liver metastases and 9 abdominal disseminations). Serum carcinoembryonic antigen level, carbohydrate antigen 19-9 level, neutrophil-lymphocyte ratio and modified Glasgow prognostic score were significantly higher in the EL group than in the resected group, and these factors were prognostic. Among these factors, carcinoembryonic antigen > 7 ng/mL was the most useful to predict occult metastasis in BTC. When patients have more than three of these positive factors, the rate of occult metastasis increases. CONCLUSION: Inflammation-based prognostic scores and tumor markers are useful in detecting occult metastasis in BTC; based on these factors, staging laparoscopy may reduce the rate of EL.Nov. 2021, World journal of clinical cases, 9(32) (32), 9770 - 9782, English, International magazineScientific journal
- BACKGROUND/PURPOSE: Approximately 8,300 hemophiliacs are registered in Japan, but no comprehensive reports on hepatobiliary and pancreatic surgery (HBPS) have been conducted. This report investigates the current status of HPBS in hemophilia patients in Japan. METHODS: The subjects were hemophiliac patients seen between January 1, 2007, and December 31, 2017, at facilities participating in this study among the facilities for performing high-difficulty cases nationwide designated by the Japanese Society for HBPS. A retrospective examination of short-term outcomes in 49 cases was conducted to assess patient background, disease, surgical procedure and complications. RESULTS: The types of hemophilia were A: 43 cases, B: 4 cases, and von Willebrand disease: 2 cases (hemophilia severity: mild 32, moderate 7, severe 10). The target malignant diseases for surgery were hepatocellular carcinoma (HCC) in 20 cases, intrahepatic cholangiocellular carcinoma (CCC) in 4 cases, combined HCC-CCC in 2 cases, hilar CCC in 2 cases, and pancreatic cancer in 4 cases. As for the surgical procedure, limited resection (subsegmentectomy and partial hepatectomy) was tended to be performed in 16 case of HCC even with normal liver function tests. Pancreaticoduodenectomy and distal pacreatectomy were performed for pancreatic cancers as in the standard procedure. Postoperative complications were postoperative bleeding in 2 cases after hepatectomy and 1 after pancreatectomy in 1 case. When compared with Japanese National Clinical Data base, the complication rates after hepatectomy and pancreatectomy were not conspicuous in hemophilic patients. CONCLUSIONS: As long as performed in by qualified centers, complication rate is not increased in hemophilic patients undergoing HBPS.Nov. 2021, Journal of hepato-biliary-pancreatic sciences, 29(3) (3), 385 - 393, English, Domestic magazineScientific journal
- BACKGROUND/AIM: Sarcopenia has been reported to be a significant prognostic factor in patients with hepatocellular carcinoma in recent years. This study aimed to clarify the prognostic significance of sarcopenia in advanced hepatocellular carcinoma treated with reductive hepatectomy. PATIENTS AND METHODS: We retrospectively analyzed 93 patients who underwent reductive hepatectomy for advanced hepatocellular carcinoma. RESULTS: Median survival time of the sarcopenia group (16.4 months) was significantly shorter than that of the non-sarcopenia group (20.4 months). The overall survival rates at 1, 3, and 5 years of the sarcopenia group were significantly lower than those of the non-sarcopenia group (57.9%, 8.6%, and 2.9% vs. 67.3%, 29.2%, and 15.7%, respectively; p=0.035). On multivariate analysis, sarcopenia was a significant risk factor of overall survival (hazard ratio=1.60, 95% confidence interval=1.00-2.56, p=0.049). CONCLUSION: Sarcopenia was a significant prognostic factor of survival after reductive hepatectomy in advanced hepatocellular carcinoma.Nov. 2021, Anticancer research, 41(11) (11), 5775 - 5783, English, International magazineScientific journal
- BACKGROUND: Optimal treatment strategies for advanced hepatocellular carcinoma (HCC) with macroscopic portal vein tumor thrombus (PVTT) remain controversial. Therefore, this study aimed to assess the impact and predictive factors of hepatectomy for HCC with macroscopic PVTT. METHODS: This study included 100 patients who presented with intraoperatively confirmed PVTT extending to the first portal branch (Vp3), main portal trunk, or opposite-side portal branch (Vp4) between June 2000 and December 2019. Their postoperative outcomes and predictive factors for survival were evaluated. RESULTS: Of the 100 patients, 37 (37%) and 63 (63%) had Vp3 and Vp4 PVTTs, respectively. Moreover, 42 (42%) and 58 (58%) patients underwent R0/1 and R2 hepatectomies, respectively. The median survival time (MST) of all patients with Vp3/4 PVTT was 14.5 months; the 1- and 3-year overall survival rates were 59.6 and 16.8%, respectively. The MSTs of patients with Vp3 and Vp4 PVTTs were 16.1 and 14.3 months, respectively (P = 0.7098). The MSTs of patients who underwent R0/1 and R2 hepatectomies were 14.3 and 14.9 months, respectively (P = 0.3831). All assessed tumor factors (including the Vp status [Vp3 or Vp4], type of resection [R0/1 or R2], intrahepatic maximal tumor size, intrahepatic tumor number, and the existence of extrahepatic metastasis) did not influence the overall survival significantly. CONCLUSIONS: Tumor factors, such as the presence of a Vp3/4 PVTT, have a strong impact on survival; however, other multiple tumor factors have a limited impact. Hepatectomy can be an effective treatment option for HCC with Vp3/4 PVTT, and its indications should be considered.Oct. 2021, Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 26(4) (4), 822 - 830, English, International magazineScientific journal
- BACKGROUND: Although liver transplantation is widely accepted as the therapeutic strategy for end-stage liver failure, complication of hepatic venous outflow obstruction remains lethal. Currently, ensuring a single wide orifice in both the graft and recipient inferior vena cava has been proposed to avoid hepatic venous outflow obstruction with no theoretical concept. METHODS: We herein report a standardization technique for the reconstruction of the hepatic vein based on the causal analysis. RESULTS: During the put-in process, the graft must be positioned in contact with the recipient diaphragm and slightly pushed to the cranial direction to simulate the state after abdominal closure. Because there is no extra space between the graft and diaphragm, the graft could not rotate about the anastomotic site of the inferior vena cava toward the diaphragm after abdominal closure as the intestinal pressure increases, and accordingly hepatic venous outflow obstruction does not develop. CONCLUSIONS: With this concept, all transplant surgeons can successfully and easily perform hepatic vein reconstruction without total clamping of the inferior vena cava and without outflow block.Oct. 2021, Transplantation proceedings, 53(10) (10), 2934 - 2938, English, International magazineScientific journal
- Close attachment of soft tissues onto implantable devices inside the body is regarded as an optimal condition for preventing complications (e.g., infections and abscess formation around implants, and the migration of small injectable devices). We have recently reported that an α-type commercially pure Ti (CpTi) film after a long-term acid treatment and air drying showed a remarkable soft tissue adhesiveness immediately (i.e., within a few seconds) after the attachment onto soft tissues. Herein, we conducted acid treatment for (α + β)-type Ti-6Al-4V alloys and compared their mechanical properties and the immediate soft-tissue adhesiveness with α-type CpTi. The acid treatment for Ti-6Al-4V also promoted immediate soft-tissue adhesion, although the treatment was less effective than for CpTi. The tensile strength of acid-treated Ti-6Al-4V was much higher than that of acid-treated CpTi or human skin tissues, although the degree of hydrogen embrittlement was more severe than that for CpTi. These results suggest that the small amount of Al in the major α phase and/or the minor β phase of Ti-6Al-4V has a significant influence not only on the mechanical properties but also on the immediate soft-tissue adhesiveness of Ti-based solid-state adhesives after the acid treatment.Oct. 2021, Journal of materials chemistry. B, 9(39) (39), 8348 - 8354, English, International magazineScientific journal
- OBJECTIVE: To investigate the diagnostic performance of the extracellular volume (ECV) fraction in multiphasic contrast-enhanced computed tomography (CE-CT) for estimating histologic pancreatic fibrosis and predicting postoperative pancreatic fistula (POPF). METHODS: Eighty-five patients (49 men; mean age, 69 years) who underwent multiphasic CE-CT followed by pancreaticoduodenectomy with pancreaticojejunal anastomosis between January 2012 and December 2018 were retrospectively included. The ECV fraction was calculated from absolute enhancements of the pancreas and aorta between the precontrast and equilibrium-phase images, followed by comparisons among histologic pancreatic fibrosis grades (F0‒F3). The diagnostic performance of the ECV fraction in advanced fibrosis (F2‒F3) was evaluated using receiver operating characteristic curve analysis. Multivariate logistic regression analysis was used to evaluate the associations of the risk of POPF development with patient characteristics, histologic findings, and CT imaging parameters. RESULTS: The mean ECV fraction of the pancreas was 34.4% ± 9.5, with an excellent intrareader agreement of 0.811 and a moderate positive correlation with pancreatic fibrosis (r = 0.476; p < 0.001). The mean ECV fraction in advanced fibrosis was significantly higher than that in no/mild fibrosis (44.4% ± 10.8 vs. 31.7% ± 6.7; p < 0.001), and the area under the receiver operating characteristic curve for the diagnosis of advanced fibrosis was 0.837. Twenty-two patients (25.9%) developed clinically relevant POPF. Multivariate logistic regression analysis demonstrated that the ECV fraction was a significant predictor of POPF. CONCLUSIONS: The ECV fraction can offer quantitative information for assessing pancreatic fibrosis and POPF after pancreaticojejunal anastomosis. KEY POINTS: • There was a moderate positive correlation of the extracellular volume (ECV) fraction of the pancreas in contrast-enhanced CT with the histologic grade of pancreatic fibrosis (r = 0.476; p < 0.001). • The ECV fraction was higher in advanced fibrosis (F2‒F3) than in no/mild fibrosis (F0‒F1) (p < 0.001), with an AUC of 0.837 for detecting advanced fibrosis. • The ECV fraction was an independent risk factor for predicting subclinical (odds ratio, 0.81) and clinical (odds ratio, 0.80) postoperative pancreatic fistula.Oct. 2021, European radiology, English, International magazine, Co-authored internationallyScientific journal
- BACKGROUND: Radical antegrade modular pancreatosplenectomy (RAMPS) is an isolation procedure in pancreatosplenectomy for pancreatic body/tail cancer. Connective tissues around the bifurcation of the celiac axis are dissected, followed by median-to-left retroperitoneal dissection. This procedure has the potential to isolate blood and lymphatic flow to the area of the pancreatic body/tail and the spleen to be excised. This is achieved by division of the inflow artery, transection of the pancreas, and then division of the outflow vein in the early phases of surgery. In cases of pancreatic ductal adenocarcinoma (PDAC), the procedure has been shown to decrease intraoperative blood loss and increase R0 resection rate by complete clearance of the lymph nodes. This trial investigates whether the isolation procedure can prolong the survival of patients with pancreatic ductal adenocarcinoma who undergo distal pancreatosplenectomy (DPS) compared with those that undergo the conventional approach. METHODS/DESIGN: Patients with PDAC scheduled to undergo DPS are randomized before surgery to undergo either a conventional procedure (arm A) or to undergo the isolation procedure (arm B). In arm A, the pancreatic body, tail, and spleen are mobilized, followed by removal of the regional lymph nodes. The splenic vein is transected at the end of the procedure. The timing of division of the splenic artery (SA) is not restricted. In arm B, regional lymph nodes are dissected, then we transect the root of the SA, the pancreas, then the splenic vein. At the end of the procedure, the pancreatic body/tail and spleen are mobilized and removed. In total, 100 patients from multiple Japanese high-volume centers will be randomized. The primary endpoint is 2-year recurrence-free survival by intention-to-treat analysis. Secondary endpoints include intraoperative blood loss, R0 resection rate, and overall survival. DISCUSSION: If this trial shows that the isolation procedures can improve survival with a similar R0 rate and with a similar number of lymph node dissections to the conventional procedure, the isolation procedure is expected to become a standard procedure during DPS for PDAC. Conversely, if there were no significant differences in endpoints between the groups, it would demonstrate justification of either procedure from surgical and oncological points of view. TRIAL REGISTRATION: UMIN Clinical Trials Registry UMIN000041381 . Registered on 10 August 2020. ClinicalTrials.gov NCT04600063 . Registered on 22 October 2020.Sep. 2021, Trials, 22(1) (1), 633 - 633, English, International magazineScientific journal
- BACKGROUND: Effects of pancreatectomy on glucose tolerance have not been clarified, and evidence regarding the difference in postoperative glucose tolerance between pancreaticoduodenectomy (PD) and distal pancreatectomy (DP) is lacking. STUDY DESIGN: This prospective, single-center observational study analyzed 40 patients undergoing PD and 29 patients undergoing DP (Clinical trial registry number UMIN000008122). Glucose tolerance, including insulin secretion (Δ C-peptide immunoreactivity, ΔCPR) and insulin resistance (homeostasis model assessment of insulin resistance, HOMA-IR) were assessed before and 1 month after pancreatectomy using the oral glucose tolerance test (OGTT) and glucagon stimulation test. We assessed long-term hemoglobin A1c (HbA1c) levels in patients, with a follow-up time of 3 years. RESULTS: Percentages of patients diagnosed with abnormal OGTT decreased after PD (from 12 [30%] to 7 [17.5%] of 40 patients, p = 0.096); however, they increased after DP (from 4 [13.8%] to 8 [27.6%] of 29 patients, p = 0.103), although the changes were not statistically significant. ΔCPR decreased after both PD (from 3.2 to 1.0 ng/mL, p < 0.001) and DP (from 3.3 to 1.8 ng/mL, p < 0.001). HOMA-IR decreased after PD (from 1.10 to 0.68, p < 0.001), but did not change after DP (1.10 and 1.07, p = 0.42). Median HbA1c level was higher after DP than after PD for up to 3 years, but the differences were not statistically significant. CONCLUSIONS: In comparisons of pre- and 1 month post-pancreatectomy data, glucose tolerance showed improvement after PD, whereas it worsened after DP. Insulin secretion decreased after both PD and DP. Insulin resistance improved after PD, but did not change after DP. Further studies are warranted to clarify mechanisms of improved insulin resistance after PD.Sep. 2021, Journal of the American College of Surgeons, English, International magazineScientific journal
- Aim: With the increased use of particle therapy for liver cancer, local recurrence after particle therapy increased. Salvage hepatectomy is an acceptable treatment option for local recurrence following particle therapy; however, its safety and effectiveness remain unclear. Therefore, this multi-center study aimed to verify the feasibility and efficacy of salvage hepatectomy and assess clinical issues associated with its application. Methods: We retrospectively assessed the perioperative outcomes, prognosis, and pathological characteristics of 15 patients who underwent salvage hepatectomy for local recurrence after particle therapy between 2006 and 2019. Results: Hepatocellular carcinoma and metastatic liver tumors were noted in eight and seven patients, respectively. The mean total dose and number of fractions were 66.5 Gy and 12, respectively, and the mean interval between particle therapy and surgery was 30.1 months. Major hepatectomy was performed in seven cases. Moreover, the mortality rate was 0%, and surgical complications of Clavien-Dindo grade IIIa or higher were observed in four cases (27%)-two bile leakages, one pleural effusion, and one refractory skin fistula. The median overall survival time and 5-year overall survival rate after salvage hepatectomy were 29.9 months and 43.1%, respectively. Histological examination of the irradiated liver tissue surrounding the tumor showed sinusoidal dilatation, loss of hepatocyte, and fibrosis in most cases. Conclusion: Salvage hepatectomy after particle therapy is a feasible therapy; however, the risk of refractory complications associated with particle therapy is relatively high. Therefore, the first-line treatment for resectable liver cancer should be carefully determined considering second-line treatment after local recurrence.Sep. 2021, Annals of gastroenterological surgery, 5(5) (5), 711 - 719, English, Domestic magazineScientific journal
- BACKGROUND/AIM: While there is increasing evidence supporting the role of several first- and second-line treatment regimens for advanced hepatocellular carcinomas (HCC), the clinical relevance of rechallenge treatment with previously administered drugs, however, remains to be explored. PATIENTS AND METHODS: Five consecutive patients with advanced HCC who received lenvatinib rechallenge treatment after ramucirumab were assessed. RESULTS: All patients were clinically diagnosed with failure after ramucirumab treatment, and the frequencies of ramucirumab administration before lenvatinib re-administration ranged from 3 to 11. The alfa-fetoprotein level in four of five patients decreased 1 month after the lenvatinib rechallenge. Radiological findings via the modified Response Evaluation Criteria in Solid Tumors showed stable diseases in four patients and a partial response in one. CONCLUSION: Rechallenge treatment with lenvatinib after ramucirumab can be effective, and may be a treatment option for HCC in cases wherein the disease progressed after an initial response to lenvatinib treatment.Sep. 2021, Anticancer research, 41(9) (9), 4555 - 4562, English, International magazineScientific journal
- Highlight Venous tumor thrombus can occur in association with pancreatic neuroendocrine neoplasm. Ishida and colleagues report their experience with a patient in whom a solitary recurrent tumor developed in the portal vein after pancreaticoduodenectomy for pancreatic neuroendocrine neoplasm. They performed portal vein resection and reconstruction using a left external iliac vein graft.Aug. 2021, Journal of hepato-biliary-pancreatic sciences, 28(8) (8), e36-e37, English, Domestic magazineScientific journal
- (一社)日本内視鏡外科学会, Jul. 2021, 日本内視鏡外科学会雑誌, 26(4) (4), 285 - 291, Japanese
- Indication of Surgical Hepatectomy for the Patients of Hepatocellular Carcinoma with Inferior Vena Cava Tumor Thrombosis.The prognosis of hepatocellular carcinoma (HCC) presenting with inferior vena cava tumor thrombus (IVCTT) is extremely poor. The aim of this study was to reveal the postoperative course and to identify patients who have survived surgical hepatectomy among HCC patients with IVCTT. Between January 2006 and December 2018, 643 patients underwent surgical hepatectomy for HCC at Kobe University Hospital. Among them, 20 patients were categorized as Vv3 according to the Japanese staging system. We retrospectively collected detailed data on these patients. The statistical, clinical, and pathological data were recorded prospectively and analyzed retrospectively. The median survival time was 9.8 months. Among all patients, 11 (55%) achieved R0 resection, and only two survivors were from this group. The number of tumors (solitary vs. multiple; p=0.050) and pathological Vp (pVp0 vs. other; p=0.009) were identified as risk factors for overall survival in the univariate analysis. In the multivariate analysis, pathological Vp (pVp0 vs. other; p=0.037) was identified as a significant prognostic factor for survival. Pathological Vp affected overall survival among IVCTT patients; the median survival time was 53.7 months with pVp0, 10.2 months with pVp1, and 8.8 months with pVp2-4 (p=0.035). For patients with IVCTT, surgical hepatectomy should be indicated only for those who do not have portal vein invasion and could achieve R0 resection.Jun. 2021, The Kobe journal of medical sciences, 67(1) (1), E10-E17, English, Domestic magazineScientific journal
- AIM: This study aims to validate Japanese diagnostic criteria for acute-on-chronic liver failure (ACLF) and confirm the feasibility of performing transplantation. METHODS: We included 60 patients with acute liver injury. Demographic and clinical features were retrospectively collected, and the primary outcome was compared among 4 types: acute liver failure (ALF) with hepatic coma (n = 23), ALF without hepatic coma (n = 12), acute liver injury (n = 20), and ACLF (n = 5). Moreover, 80 transplanted patients were enrolled to compare the difficulty of transplantation between ALF (n = 8) vs non-ALF (n = 72) patients. RESULTS: Seven patients in the ALF with hepatic coma group and 1 patient in the ACLF with hepatic coma group were transplanted. Ten patients who could not be registered for transplantation died. In univariate analysis, liver failure type (P < .0001), total bilirubin level (P = .05), and prothrombin time internationalized ratio (P < .0001) were associated with patient survival. In multivariate analysis, liver failure type was associated with patient survival (P < .0001). The respective 1-, 3-, and 5-year patient survival rates were 45.9%, 45.9%, and 45.9% for ALF patients with hepatic coma; 100.0%, 100.0%, and 100.0% for ALF patients without hepatic coma and acute liver injury; and 80.0%, 80.0%, and 80.0% for ACLF patients (P < .0001). Chronic liver disease did not affect operation time (P = .46) and bleeding volume (P = .49). CONCLUSION: Patients diagnosed with ACLF via Japanese criteria presented significantly higher survival rates than ALF patients with hepatic coma.Jun. 2021, Transplantation proceedings, 53(5) (5), 1611 - 1615, English, International magazineScientific journal
- (一社)日本消化器内視鏡学会, Apr. 2021, Gastroenterological Endoscopy, 63(Suppl.1) (Suppl.1), 980 - 980, Japanese内視鏡的乳頭切除術を行った早期十二指腸乳頭部腫瘍の予後に関する検討
- BACKGROUND/AIM: Few studies have established a definite conclusion regarding the limitation of surgical treatment for patients with Barcelona Clinic Liver Cancer (BCLC) stage B and C hepatocellular carcinoma (HCC). PATIENTS AND METHODS: A retrospective analysis was performed on 717 consecutive patients who underwent initial hepatectomy for HCC. RESULTS: Reductive hepatectomy was performed in 103 patients, with a median survival time (MST) of 18.0 months. Total bilirubin and albumin levels were identified as independent prognostic factors. The predictive score of these factors ranged from 0 to 2. Subsequent local treatment was performed in 91.0, 75.0, and 25.0% of patients who scored 0, 1, and 2, respectively. The MST for patients with a score of 0, 1, and 2 was 20.1, 14.8, and 2.7 months, respectively, with a significant difference. CONCLUSION: Patients with BCLC stage B and C could be properly treated with reductive hepatectomy and subsequent local treatments.Apr. 2021, Anticancer research, 41(4) (4), 1975 - 1983, English, International magazineScientific journal
- (一社)日本消化器内視鏡学会, Apr. 2021, Gastroenterological Endoscopy, 63(Suppl.1) (Suppl.1), 980 - 980, Japanese内視鏡的乳頭切除術を行った早期十二指腸乳頭部腫瘍の予後に関する検討
- Mar. 2021, 手術, 75(3) (3), 273 - 279, Japanese【特集 肝胆膵外科における再切除と再手術―最新の治療戦略】粒子線治療後再発に対するサルベージ肝切除Scientific journal
- PURPOSE: This study retrospectively investigated relationships among risk factors and post-hepatectomy surgical site infection (SSI) and other complications in patients who underwent hepatectomy for hepatocellular carcinoma (HCC). METHODS: We included 334 patients who underwent hepatectomies for liver cancers between January 2011 and December 2015 in this study. We evaluated risk factors for SSI and other post-hepatectomy complication, including demographic factors, preoperative factors, and preoperative intervention including oral management, perioperative factors, and length of hospital stay, with univariate and multivariate analyses. The oral management intervention included self-care instructions, extraction of infected teeth, removal of dental plaques and calculus (scaling), professional mechanical teeth cleaning, removal of tongue coating, and cleaning of dentures. SSI was defined in accordance with the guideline issued by the Centers for Disease Control and Prevention; it included purulent discharge from any incision or organ space within 30 days postoperatively, with or without microbiological evidence. Complications of grade II or greater, according to the Clavien-Dindo classification, were regarded as postoperative complications. RESULTS: We found bacterial infection of ascites (Odds ratio (OR) = 13.72), lack of preoperative oral management intervention (OR = 10.17), and severe liver fibrosis (OR = 2.76) to be associated with SSI and severe liver fibrosis (OR = 2.28), hypoalbuminemia (OR = 2.02), blood transfusion (OR = 1.86), and longer operation time (OR = 1.80) to be associated with postoperative complications. CONCLUSIONS: Preoperative oral management may reduce the risk of SSI in patients with HCC who undergo hepatectomy.Feb. 2021, Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 29(2) (2), 653 - 659, English, International magazineScientific journal
- BACKGROUND: This study was performed to investigate the oncologic role of lymph node (LN) management and to propose a surgical strategy for treating intrahepatic cholangiocarcinoma (IHCC). METHODS: The medical records of patients with resected IHCC were retrospectively reviewed from multiple institutions in Korea and Japan. Short-term and long-term oncologic outcomes were analyzed according to lymph node metastasis (LNM). A nomogram to predict LNM in treating IHCC was established to propose a surgical strategy for managing IHCC. RESULTS: A total of 1138 patients were enrolled. Of these, 413 patients underwent LN management and 725 did not. A total of 293 patients were found to have LNM. The No. 12 lymph node (36%) was the most frequent metastatic node, and the No. 8 lymph node (21%) was the second most common. LNM showed adverse long-term oncologic impact in patients with resected IHCC (14 months, 95% CI (11.4-16.6) vs. 74 months, 95% CI (57.2-90.8), p < 0.001), and the number of LNM (0, 1-3, 4≤) was also significantly related to negative oncologic impacts in patients with resected IHCC (74 months, 95% CI (57.2-90.8) vs. 19 months, 95% CI (14.4-23.6) vs. 11 months, 95% CI (8.1-13.8)), p < 0.001). Surgical retrieval of more than four (≥4) LNs could improve the survival outcome in resected IHCC with LNM (13 months, 95% CI (10.4-15.6)) vs. 30 months, 95% CI (13.1-46.9), p = 0.045). Based on preoperatively detectable parameters, a nomogram was established to predict LNM according to the tumor location. The AUC was 0.748 (95% CI: 0.706-0.788), and the Hosmer and Lemeshow goodness of fit test showed p = 0.4904. CONCLUSION: Case-specific surgical retrieval of more than four LNs is required in patients highly suspected to have LNM, based on a preoperative detectable parameter-based nomogram. Further prospective research is needed to validate the present surgical strategy in resected IHCC.Jan. 2021, Cancers, 13(3) (3), English, International magazine, Co-authored internationally[Refereed]Scientific journal
- BACKGROUND: Intrahepatic cholangiocarcinoma had been considered a contraindication for liver transplantation because of poorer outcomes. However, incidental intrahepatic cholangiocarcinoma in the explanted liver has been reported because of the difficulty of obtaining an accurate diagnosis in cirrhotic livers on preoperative imaging. METHODS: We conducted a nationwide survey to analyze the incidence of incidental intrahepatic cholangiocarcinoma and outcomes after liver transplantation, in Japan. RESULTS: Forty-five of 64 institutions (70%) responded to our initial investigation. Between January 2001 and December 2015, 6627 liver transplantations were performed in these 45 institutions, with 19 cases (0.3%) of incidental intrahepatic cholangiocarcinoma reported from 12 transplant centers. Six cases were diagnosed as hepatocellular carcinoma preoperatively. The 1-, 3-, and 5-year recurrence-free survival rates were 79%, 45%, and 45%, respectively. Tumor recurrence after liver transplantation was found in 10 patients (53%). The 1-, 3-, and 5-year overall survival rates were 79%, 63%, and 46%, respectively. CONCLUSIONS: Intrahepatic cholangiocarcinoma at liver transplantation is associated with a high risk of recurrence and poor prognosis, even these tumors are detected incidentally in the explanted liver.Jan. 2021, Journal of hepato-biliary-pancreatic sciences, 28(4) (4), 346 - 352, English, Domestic magazineScientific journal
- BACKGROUND: Particle radiotherapy has increasingly gained acceptance for locally advanced pancreatic cancers owing to superior tumor conformity and dosimetry compared to conventional photon radiotherapy. However, the close proximity of the pancreas to the stomach and duodenum leads to radiation-induced gastrointestinal toxicities, which hinder the delivery of curative doses to the tumor. To overcome this problem, a surgical spacer was placed between the tumor and gastrointestinal tract, and subsequent proton radiotherapy was performed in this study. METHODS: Data from 9 patients who underwent surgical spacer placement and subsequent proton radiotherapy were analyzed. The safety and feasibility of the spacer placement surgery were evaluated; the impact of the spacer on dosimetry was also assessed using dose volume histogram (DVH) analyses, before and after surgical spacer placement. RESULTS: Surgical spacer placement and subsequent proton radiotherapy were successfully completed in all cases. Surgical spacer placement significantly improved the dose intensity covering 95%, mean, and minimum doses for the gross tumor volume, and the clinical and planning target volume based on the DVH, while respecting the dose constraints of the gastrointestinal tract. Based on the Common Terminology Criteria for Adverse Events, two patients (22.2%) developed gastrointestinal ulcer (Grade 2) at 1 and 35 months, and one patient (11.1%) developed gastric perforation (Grade 4) at 4 months after proton radiotherapy. CONCLUSIONS: Surgical spacer placement in the locally advanced pancreatic body and tail cancers is relatively safe and technically feasible. Comparing radiation plans, surgical spacer placement seems to improve the dose distribution in the locally advanced pancreatic body and tail cancers, which are close to the gastrointestinal tract.Jan. 2021, Radiation oncology (London, England), 16(1) (1), 3 - 3, English, International magazineScientific journal
- Last, Jan. 2021, 別冊日本臨牀 領域別症候群シリーズ 肝・胆道系症候群(第3版), 13(1) (1), 378 - 381, Japanese【肝内胆汁うっ滞在】肝移植後胆管合併症Scientific journal
- BACKGROUND: Intraductal papillary mucinous neoplasm (IPMN) of the pancreas is associated with acute pancreatitis (AP) in some cases, however its causes have not been fully elucidated. We investigated the association of the incidence of AP with epithelial subtypes and pancreatic volume in IPMN. METHODS: This retrospective study included 182 consecutive surgically resected IPMN patients between January 2000 and December 2018. The relationship between the incidence of AP and epithelial subtypes of IPMN and pancreatic volume was investigated. Epithelial subtypes of IPMN were classified into gastric (G type: N = 116), intestinal (I type: N = 49), pancreatobiliary (PB type: N = 14), and oncocytic types (O type: N = 3). Pancreatic volume of the contrast-enhanced computed tomography scan was measured using Ziostation2 software. Histological pancreatic parenchymal atrophy was also evaluated. RESULTS: AP occurred more frequently in I-types (I-type vs. G-type, 22.4% [11/49] vs 3.4% [4/116], P = 0.003) and PB-types (PB type vs. G-type, 35.7% [5/14] vs. 3.4% [4/116], P = 0.007) in comparison with G-types, which constituted the majority of the resected IPMNs. AP occurred more frequently in I-type patients with high pancreatic volumes (I-type with high pancreatic volume vs. I-type with low pancreatic volume, 37.0% [10/27] vs. 4.7% [1/21], P = 0.02). However, histological atrophy did not show an additional influence on the association between the incidence of AP and epithelial subtypes. The elevation of serum pancreatic enzymes was not significantly related to epithelial subtypes. CONCLUSION: Epithelial subtypes and the degree of pancreatic volume may be closely associated with the incidence of AP in IPMN.Jan. 2021, Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 21(1) (1), 138 - 143, English, International magazineScientific journal
- BACKGROUND/AIM: We aimed to investigate the dosimetric effects of a spacer placed between the pancreas and surrounding gastrointestinal structures in intensity-modulated radiation therapy (IMRT) planning to provide more effective radiation therapy for locally advanced pancreatic cancer (LAPC). PATIENTS AND METHODS: Treatment planning was performed for six patients with LAPC based on computed tomography images without spacers and with 5-mm or 10-mm spacers virtually inserted under the supervision of a hepatobiliary pancreatic surgeon. The prescription dose was 63 Gy in 28 fractions. RESULTS: With the exception of one case of pancreatic head cancer, planning target volume receiving ≥95% of the prescribed dose (PTV V95) was achieved by 90% or more by inserting a spacer, and by 95% or more in all 3 cases of pancreatic body and tail cancer by inserting a 10-mm spacer. CONCLUSION: IMRT with appropriate spacer placement may help provide high-dose treatment for LAPC and improve associated patient outcomes.Jan. 2021, Anticancer research, 41(1) (1), 503 - 508, English, International magazineScientific journal
- Background: Within the class of tyrosine kinase inhibitors (TKIs), which are used for the treatment of numerous advanced cancers, lenvatinib is associated with a higher prevalence of hypertension (HT) compared with other TKIs. In this study, we investigated the effect of lenvatinib on blood pressure (BP) and associated factors. Methods: This single-centre, retrospective observational study included 25 consecutive patients treated with lenvatinib for unresectable hepatocellular carcinoma from April 2018 to December 2018 at the study institution. We assessed changes in BP using ambulatory BP monitoring, urinary sodium excretion, kidney function, use of antihypertensive agents and diuretics, and fluid retention following treatment initiation with lenvatinib. Results: At 1 week after treatment initiation, the mean BP and the percentage of patients with riser pattern significantly increased compared with those at the baseline. Although there were no significant changes at 1 week, urinary sodium excretion (153.4 ± 51.7 and 112.5 ± 65.0 mEq/day at 1 and 3 weeks, respectively, P < 0.05) and estimated glomerular filtration rate significantly decreased and the number of patients with fluid retention increased at 3 weeks. Furthermore, patients with fluid retention had significantly higher BP or required more intensive BP treatment compared with those without fluid retention. Conclusions: Lenvatinib might lead to HT without fluid retention soon after the initiation of treatment, subsequently leading to a reduction in urinary sodium excretion, thereby contributing to a rise in BP by fluid retention.Jan. 2021, Clinical kidney journal, 14(1) (1), 325 - 331, English, International magazineScientific journal
- PURPOSE: Metallic medical devices are typically constructed from non-bioabsorbable metals that remains in the body and causes considerable complications. Particularly in the urinary tract, calculus, intractable infection, and misdiagnosis as calculus are often caused by non-bioabsorbable metals. Here, we developed a zinc-magnesium alloy as a new bioabsorbable metal and sought to evaluate the bioabsorbable behavior of zinc and zinc-magnesium alloy in a rat bladder implantation model. METHODS: We prepared zinc-magnesium alloy wires with various proportions of magnesium and investigated the strength, shape retention, formability, and absorbability of these novel materials. Then, we implanted zinc and zinc-magnesium alloy rings formed by the wires into rat bladder. Rats were euthanized at the end of the observation period, and the rings were removed for volume evaluation. Extracted bladder tissues were subjected to histological analysis. RESULTS: The strength of the zinc wire was enhanced by more than fourfold upon the addition of magnesium, without loss of ductility. Linear reduction of ring volume in urine was observed based on the concentration of magnesium within the ring. Nearly all rings were covered with a thin layer of calculus. Histological findings of the transected urinary bladder tissues did not differ among groups. CONCLUSIONS: Zinc-magnesium alloy is a promising candidate for use as a bioabsorbable medical device in the urinary tract.Jan. 2021, World journal of urology, 39(1) (1), 201 - 208, English, International magazine[Refereed]Scientific journal
- This study aimed to establish an immunohistochemical panel useful for subclassification of intrahepatic cholangiocarcinoma (iCCA) into small- and large-duct types. Fifty surgical cases of iCCA consisting of small- (n = 31) and large-duct types (n = 19) were examined. To imitate liver needle biopsies, tissue microarrays were constructed using three tissue cores (2 mm in diameter) obtained from one representative paraffin block of each case. Immunostaining for C-reactive protein (CRP), N-cadherin, tubulin beta-III (TUBB3), neural cell adhesion molecule (NCAM), and S100 calcium binding protein P (S100P) was conducted. Most cases of small-duct iCCA were immunoreactive to CRP and N-cadherin, whereas expressions of these markers were markedly less common in large-duct iCCA (CRP, 97% vs. 5%, P < 0.001; N-cadherin, 87% vs. 16%, P < 0.001). TUBB3 and NCAM were also more frequently expressed in small-duct iCCA (65% vs. 32%, P = 0.006; 58% vs. 5%, P < 0.001), but their sensitivities were lower than those of CRP and N-cadherin. S100P was more commonly expressed in large-duct iCCA than in small-duct iCCA (95% vs. 29%, P < 0.001), and diffuse expressions were observed in 17 of 19 cases of large-duct iCCA (90%). All cases with a CRP+/S100P- immunophenotype were of small-duct type, whereas all but one case with a CRP-/S100P+ immunophenotype were of large-duct type. Of 10 cases with a double-positive or double-negative immunophenotype, 7 were appropriately classified based on immunoreactivity to N-cadherin. In conclusion, CRP, N-cadherin, and S100P form a useful immunohistochemical panel for iCCA subclassification, and correct subclassification was possible in 92% of cases based on a proposed, simple algorithm.Dec. 2020, Human pathology, 109, 45 - 52, English, International magazine, Co-authored internationallyScientific journal
- Dec. 2020, Pediatric blood & cancer, 68(5) (5), e28842, English, International magazine
- BACKGROUND: Postoperative biliary strictures are commonly related to accidental bile duct injuries or occur at the site of biliary anastomosis. The first-line treatment for benign biliary strictures is endoscopic therapy, which is less invasive and repeatable. However, recanalization for biliary complete obstruction is technically challenging to treat. The present report describes a successful case of treatment by extraluminal recanalization for postoperative biliary obstruction using a transseptal needle. CASE PRESENTATION: A 66-year-old woman had undergone caudal lobectomy for the treatment of hepatocellular carcinoma. The posterior segmental branch of the bile duct was injured and repaired intraoperatively. Three months after the surgery, the patient had developed biliary leakage from the right hepatic bile duct, resulting in complete biliary obstruction. Since intraluminal recanalization with conventional endoscopic and percutaneous approaches with a guidewire failed, extraluminal recanalization using a transseptal needle with an internal lumen via percutaneous approach was performed under fluoroscopic guidance. The left lateral inferior segmental duct was punctured, and an 8-F transseptal sheath was introduced into the ostium of right hepatic duct. A transseptal needle was advanced, and the right hepatic duct was punctured by targeting an inflated balloon that was placed at the end of the obstructed right hepatic bile duct. After confirming successful puncture using contrast agent injected through the internal lumen of the needle, a 0.014-in. guidewire was advanced into the right hepatic duct. Finally, an 8.5-F internal-external biliary drainage tube was successfully placed without complications. One month after the procedure, the drainage tube was replaced with a 10.2-F drainage tube to dilate the created tract. Subsequent endoscopic internalization was performed 5 months after the procedure. At the 1-year follow-up examination, there was no sign of biliary obstruction and recurrence of hepatocellular carcinoma. CONCLUSIONS: Recanalization using a transseptal needle can be an alternative technique for rigid biliary obstruction when conventional techniques fail.Dec. 2020, Surgical case reports, 6(1) (1), 304 - 304, English, International magazineScientific journal
- A 60-year-old male visited a previous hospital with upper abdominal pain. He was diagnosed with localized mild acute pancreatitis. Three months later, abdominal contrast-enhanced computed tomography showed focal parenchymal atrophy of the pancreas with distal pancreatic duct dilation. No obvious solid mass could be found at the site of the pancreatic duct stenosis on imaging examinations. Endoscopic retrograde pancreatography showed focal mild stenosis with distal pancreatic duct dilation in the tail of the pancreas. Carcinoma in situ of the pancreas was strongly suspected, especially based on the presence of focal atrophy of the pancreas around the site of stenosis of the main pancreatic duct and the distal pancreatic duct dilation. Laparoscopic distal pancreatectomy was performed. Histologically, high-grade pancreatic intraepithelial neoplasia was found in the epithelium of the stenotic main pancreatic duct and its branches. This case suggests that localized acute pancreatitis and focal atrophy of the pancreas with distal dilation of the pancreatic duct could be important clinical manifestations of pancreatic carcinoma in situ.Dec. 2020, Clinical journal of gastroenterology, 13(6) (6), 1338 - 1342, English, Domestic magazineScientific journal
- AIM: Direct-acting antivirals for hepatitis C virus have reduced the decompensation risk. Immunosuppressants for transplantation raise the risk of occurrence of de novo malignancies. We assessed the probabilities of and risk factors for de novo hepatocellular carcinoma (HCC) development post-living donor liver transplantation (LDLT). METHODS: We retrospectively evaluated the data of developed HCC in a graft including metastatic HCC post-LDLT from 2779 adult cases collected from nine major liver transplantation centers in Japan. RESULTS: Of 2779 LDLT adult recipients, 34 (1.2%) developed HCCs in their grafts. Of 34, five HCCs appeared to be de novo because of a longer period to tumor detection (9.7 [6.4-15.4] years) and no HCC within the native liver of the two recipients. The donor origin of three of five de novo HCCs was confirmed using microsatellite analysis in resected tissue. Primary disease of all five was hepatitis C virus-related cirrhosis, of which two were treated with direct-acting antivirals. Four of five developed HCC de novo in the hepatitis B core antibody-positive grafts. De novo HCCs had favorable prognosis; four of five were cured with complete remission. However, recurrent HCC (n = 29) in the graft had a poorer outcome, especially in patients with neutrophil to lymphocyte ratio scores above 4 (median survival time, 262 [19-463] days). CONCLUSION: Analysis of the database from major liver transplantation institutes in Japan revealed that de novo HCCs determined by microsatellite analysis were rarely detected, but the majority were successfully treated. LDLT recipients with higher risks of de novo HCC, including those with hepatitis B core antibody-positive grafts, should be carefully followed by surveillance of the liver graft.Wiley, Dec. 2020, Hepatology research : the official journal of the Japan Society of Hepatology, 50(12) (12), 1365 - 1374, English, International magazineScientific journal
- A 66-year-old Japanese man was referred to our hospital with multiple giant liver cysts. The cysts had already been detected as multiple 3-cm cysts with small nodules at another hospital 12 years prior to this presentation. The cysts were diagnosed as an intraductal papillary neoplasms of the bile duct (IPNB) occupying the right lobe of the liver. Extended right lobectomy was performed. Based on the pathological findings, the tumor was diagnosed to be an oncocytic-type IPNB with minimal invasion. This experience suggests that the progression of IPNBs occur relatively slowly. The present case might provide important information for understanding the natural history of IPNBs.Nov. 2020, Internal medicine (Tokyo, Japan), 59(22) (22), 2879 - 2883, English, Domestic magazineScientific journal
- BACKGROUND: The present study aimed to assess the clinical features of patients who received lenvatinib treatment for unresectable hepatocellular carcinoma (HCC). METHODS: The clinical characteristics, adverse events, and radiological responses were evaluated for 51 consecutive patients. RESULTS: Of the study subjects, 37 patients had Child-Pugh class A (CPA) liver function, and 14 patients had Child-Pugh class B (CPB) liver function. The overall response rates in the CPA and CPB groups were 42.9% and 25.0%, respectively, and disease control rates were 82.9% and 83.3%, respectively, without significant difference (p = 0.2621 and 0.9697). There was no significant difference between CPA and CPB groups regarding the incidence of adverse events, except for hepatic coma. No significant difference was observed in the relative dose intensity between the CPA and CPB groups, for the first month, 1-2 months, or 2-3 months (p = 0.2368, 0.9368, and 0.9293). CONCLUSION: The comparable outcomes between the CPA and CPB groups suggest the acceptability of lenvatinib treatment in patients with impaired liver function, at least in the acute phase. With careful follow-up, the dose can be relatively intensified, even in patients with impaired liver function and this may contribute to offering comparable treatment.Oct. 2020, HPB : the official journal of the International Hepato Pancreato Biliary Association, 22(10) (10), 1450 - 1456, English, International magazineScientific journal
- (株)医学書院, Sep. 2020, 臨床外科, 75(9) (9), 1024 - 1028, Japanese
- BACKGROUND: The prevalent location and incidence of intraductal papillary neoplasm of the bile duct (IPNB) and invasive carcinoma associated with them have varied markedly among studies due to differences in diagnostic criteria and tumor location. METHODS: IPNBs were classified into two types: Type 1 IPNB, being histologically similar to intraductal papillary mucinous neoplasm of the pancreas, and Type 2 IPNB, having a more complex histological architecture with irregular papillary branching or foci of solid-tubular components. Medical data were evaluated. RESULTS: Among 694 IPNB patients, 520 and 174 had Type 1 and Type 2, respectively. The levels of AST, ALT, ALP, T. Bil, and CEA were significantly higher in patients with Type 2 than in those with Type 1. Type 1 IPNB was more frequently located in the intrahepatic bile duct than Type 2, whereas Type 2 was more frequently located in the distal bile duct than Type 1 IPNB (P < 0.001). There were significant differences in 5-year cumulative survival rates (75.2% vs 50.9%; P < 0.0001) and 5-year cumulative disease-free survival rates (64.1% vs 35.3%; P < 0.0001) between the two groups. CONCLUSION: Type 1 and Type 2 IPNBs differ in their clinicopathological features and prognosis. This classification may help to further understand IPNB.Sep. 2020, Journal of hepato-biliary-pancreatic sciences, 27(9) (9), 581 - 597, English, Domestic magazine, Co-authored internationallyScientific journal
- (株)医学書院, Sep. 2020, 臨床外科, 75(9) (9), 1024 - 1028, JapaneseScientific journal
- PURPOSE: Accurate prediction of post-hepatectomy liver failure (PHLF) is important in advanced hepatocellular carcinoma (HCC). We aimed to retrospectively evaluate the utility of gadoxetic acid-enhanced MRI for predicting PHLF in patients who underwent anatomic hepatectomy for HCC with portal vein invasion. METHODS: Forty-one patients (32 men, 9 women) were included. Hepatobiliary-phase MR images were acquired 20 min after injection of gadoxetic acid using a 3D fat-suppressed T1-weighted spoiled gradient-echo sequence. Liver-spleen ratio (LSR), remnant hepatocellular uptake index (rHUI), and HUI were calculated. The severity of PHLF was defined according to the International Study Group of Liver Surgery. Differences in LSR between the resected liver and the remnant liver, and HUI and rHUI/HUI between no/mild and severe PHLF were compared using the Wilcoxon signed-rank test and Wilcoxon rank-sum test, respectively. Univariate and multivariate logistic regression analyses were performed to identify predictors of severe PHLF. Areas under the receiver operating characteristic curves (AUCs) of rHUI and rHUI/HUI were calculated for predicting severe PHLF. RESULTS: Nine patients developed severe PHLF. LSR of the remnant liver was significantly higher than that of the resected liver (P < 0.001). Severe PHLF demonstrated significantly lower rHUI (P < 0.001) and rHUI/HUI (P < 0.001) compared with no/mild PHLF. Multivariate logistic regression analysis showed that decreased rHUI (P = 0.012, AUC=0.885) and rHUI/HUI (P = 0.002, AUC=0.852) were independent predictors of severe PHLF. CONCLUSION: Gadoxetic acid-enhanced MRI can be a promising noninvasive examination for assessing global and regional liver function, allowing estimation of the functional liver remnant and accurate prediction of severe PHLF before hepatic resection.Sep. 2020, European journal of radiology, 130, 109189 - 109189, English, International magazineScientific journal
- This is the response article to correspondence article received for our published article in BMC surgery titled "A prospective single-center protocol for using near-infrared fluorescence imaging with indocyanine green during staging laparoscopy to detect small metastasis from pancreatic cancer". Peter L. Labib, MBChB pointed out the necessity to administer indocyanine green intravenously in separate timing for detection of metastasis in liver and peritoneum. Preoperative injection is suitable to detect hepatic metastasis and intraoperative injection is reported to be well suited to detect peritoneal metastasis. However, we could not find the usefulness of intraoperative injection of indocyanine green for detecting peritoneal metastasis in cases with staging laparoscopy prior to this study. We employed this study protocol with only preoperative injection of indocyanine green to simplify the procedure with consideration of probably more frequent cases of hepatic metastasis that is difficult to detect with white-light imaging than those of peritoneal metastasis.Jul. 2020, BMC surgery, 20(1) (1), 153 - 153, English, International magazine
- OBJECTIVE: This study aimed to determine whether retrocolic alimentary tract reconstruction is noninferior to antecolic reconstruction in terms of DGE incidence after pancreatoduodenectomy (PD) and investigated patients' postoperative nutritional status. SUMMARY OF BACKGROUND DATA: The influence of the route of alimentary tract reconstruction on DGE after PD is controversial. METHODS: Patients from 9 participating institutions scheduled for PD were randomly allocated to the retrocolic or antecolic reconstruction groups. The primary outcome was incidence of DGE, defined according to the 2007 version of the International Study Group for Pancreatic Surgery definition. Noninferiority would be indicated if the incidence of DGE in the retrocolic group did not exceed that in the antecolic group by a margin of 10%. Patients' postoperative nutrition data were compared as secondary outcomes. RESULTS: Total, 109 and 103 patients were allocated to the retrocolic and antecolic reconstruction group, respectively (n = 212). Baseline characteristics were similar between both groups. DGE occurred in 17 (15.6%) and 13 (12.6%) patients in the retrocolic and antecolic group, respectively (risk difference; 2.97%, 95% confidence interval; -6.3% to 12.6%, which exceeded the specified margin of 10%). There were no differences in the incidence of other postoperative complications and in the duration of hospitalization. Postoperative nutritional indices were similar between both groups. CONCLUSIONS: This trial could not demonstrate the noninferiority of retrocolic to antecolic alimentary tract reconstruction in terms of DGE incidence. The alimentary tract should not be reconstructed via the retrocolic route after PD, to prevent DGE.Jul. 2020, Annals of surgery, English, International magazineScientific journal
- BACKGROUND: Several studies comparing internal and external stents have been conducted with the aim of reducing pancreatic fistula after PD. There is still no consensus, however, on the appropriate use of pancreatic stents for prevention of pancreatic fistula. This multicenter large cohort study aims to evaluate whether internal or external pancreatic stents are more effective in reduction of clinically relevant pancreatic fistula after pancreaticoduodenectomy (PD). METHODS: We reviewed 3149 patients (internal stent n = 1,311, external stent n = 1838) who underwent PD at 20 institutions in Japan and Korea between 2007 and 2013. Propensity score matched analysis was used to minimize bias from nonrandomized treatment assignment. The primary endpoint was the incidence of clinically relevant pancreatic fistula. This study was registered on the UMIN Clinical Trials Registry (UMIN000032402). RESULTS: After propensity score matched analysis, clinically relevant pancreatic fistula occurred in more patients in the external stents group (280 patients, 28.7%) than in patients in the internal stents group (126 patients, 12.9%) (OR 2.713 [95% CI, 2.139-3.455]; P < 0.001). In subset analysis of a high-risk group with soft pancreas and no dilatation of the pancreatic duct, clinically relevant pancreatic fistula occurred in 90 patients (18.8%) in internal stents group and 183 patients (35.4%) in external stents group. External stents were significantly associated with increased risk for clinically relevant pancreatic fistula (OR 2.366 [95% CI, 1.753-3.209]; P < 0.001). CONCLUSION: Propensity score matched analysis showed that, regarding clinically relevant pancreatic fistula after PD, internal stents are safer than external stents for pancreaticojejunostomy.Jul. 2020, Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 20(5) (5), 984 - 991, English, International magazine, Co-authored internationallyScientific journal
- (株)メディカル・サイエンス・インターナショナル, Jul. 2020, Intensivist, 12(3) (3), 477 - 483, JapaneseScientific journal
- Retroperitoneal cellular angiofibroma (RCA) is very rare, and the optimal treatment for RCA has not been established. We report the case of RCA in a 58-year-old man who underwent curative laparoscopy-assisted resection. Preoperative computed tomography showed heterogeneous enhancement of the 7 cm diameter tumor in the pelvis. A smaller (2.3 cm) mass was also detected in the small intestine. The preoperative diagnosis was peritoneal metastasis of the gastrointestinal tumor of the small intestine. The pelvic tumor was laparoscopically mobilized from the rectum, the left ureter, and the left internal iliac vessels. The tumor was excised by detachment from the urinary bladder in laparotomy. The pathological diagnosis was RCA. The tumor had not recurred by the 1-year follow-up. The laparoscopic approach thus might be useful for resection of RCA.Jul. 2020, Asian journal of endoscopic surgery, 13(3) (3), 431 - 434, English, Domestic magazine[Refereed]Scientific journal
- Jul. 2020, Ann Surg, 20(5) (5), 984 - 991, English, International magazine, Co-authored internationallySurgical Outcomes of Hepatocellular Carcinoma With Bile Duct Tumor Thrombus: A Korea-Japan Multicenter Study[Refereed]Scientific journal
- BACKGROUND: We compared surgical outcomes, with a focus on tumor characteristics, of laparoscopic repeat hepatectomy (LRH) and open repeat hepatectomy (ORH) to identify recurrent hepatocellular carcinoma (HCC) cases where the LRH procedure would be more favorable than ORH. METHODS: Eighty-one HCC patients who underwent repeat hepatectomy in our hospital from 2008 to 2019 were retrospectively analyzed in this study. Of these patients, 30 and 51 patients underwent LRH and ORH, respectively. We analyzed surgical outcomes of LRH and ORH, focusing on tumor characteristics such as tumor size, location, distance from major vessels, and contralateral or ipsilateral tumor recurrence to determine what factors could affect surgical outcomes. Subsequently, using a propensity-matched cohort, we compared the impact of those factors on LRH and ORH outcomes. RESULTS: In the entire cohort, the LRH operation time was significantly shorter in contralateral recurrent HCC cases than in ipsilateral recurrent HCC cases (252 vs. 398 min, P = 0.008); however, such a difference was not observed in the ORH operation time. We subsequently compared the surgical outcomes, in terms of the location of tumor recurrence, between the LRH and ORH groups in a propensity-matched cohort. In total, 23 patients were included in each of these groups. We found that the LRH procedure had significantly shorter operative time than the ORH procedure in the contralateral recurrent HCC cases (253 vs. 391 min, P = 0.018); however, we did not observe such a difference in the ipsilateral recurrent HCC cases (372 vs. 333 min, P = 0.669). LRH had lower blood loss, similar postoperative complications and shorter hospital stay than ORH in both contralateral and ipsilateral recurrent HCC cases. CONCLUSIONS: LRH is likely considered a more favorable approach than ORH in treating patients with contralateral recurrent HCC.Jun. 2020, Surgical endoscopy, English, International magazineScientific journal
- AIMS: Biliary intraductal tubular neoplasms that are non-mucinous and negative for mucin 5AC (MUC5AC) are called intraductal tubulopapillary neoplasms (ITPNs). Intraductal tubular neoplasms with mucinous cytoplasm and MUC5AC positivity also occur and their nature remains unclear, although some pathologists may classify these as 'intraductal papillary neoplasms of the bile duct (IPNBs) of gastric type'. This study aimed to elucidate genetic features of biliary intraductal tubular neoplasms. METHODS AND RESULTS: Six resected cases of biliary intraductal neoplasm with >70% tubular configuration were characterised by clinicopathological examination and whole exome sequencing, and the findings obtained were compared between MUC5AC-negative (n = 2) and -positive cases (n = 4). The intraductal tumours consisted of the pancreatobiliary-type epithelium with high-grade dysplasia arranged in back-to-back tubules. Both of the two MUC5AC-negative cases were non-invasive neoplasms and developed in the liver, whereas all MUC5AC-positive cases had invasive carcinoma and were present in the intrahepatic (n = 2), perihilar (n = 1) and distal bile ducts (n = 1). In an exome-sequencing study, MUC5AC-negative cases harboured mutations in CTNNB1, SF3B1, BAP1 and BRCA1 (one case each). KRAS mutations were observed in three of four MUC5AC-positive cases (75%) but none of the MUC5AC-negative neoplasms. Compared to published data, known driver genes of other intraductal neoplasms of the pancreatobiliary system (e.g. APC, CTNNB1, STK11, GNAS and PIK3CA) were wild-type in all but one MUC5AC-negative case with CTNNB1 mutation. Chromatin modifiers (ARID1A, BAP1 and KMT2C) were also altered in MUC5AC-positive cases, similar to usual cholangiocarcinomas. CONCLUSIONS: This exome-sequencing study suggested that MUC5AC-negative biliary ITPNs are genetically distinct from pancreatic ITPNs and IPNBs. They may also biologically differ from MUC5AC-positive tubular neoplasms despite morphological resemblance.Jun. 2020, Histopathology, 76(7) (7), 1005 - 1012, English, International magazine[Refereed]Scientific journal
- 日本胆道学会, May 2020, 胆道, 34(2) (2), 139 - 144, Japanese
- BACKGROUND: The primary definitive treatment for abdominopelvic sarcomas (APSs) is resection, although incomplete resection has a negative prognostic impact. Although the effectiveness of particle therapy (PT) as a treatment for APS has already been demonstrated, its application for tumors adjacent to the gastrointestinal tract is frequently restricted, due to extremely low tolerance. Space-making PT, consisting of surgical spacer placement and subsequent PT, has been developed to overcome this limitation. MATERIALS AND METHODS: Between June 2006 and June 2018, a total of 75 patients with 12 types of APS underwent space-making PT. RESULTS: The 3-year local control rate of all patients was 90.3%. Fourteen surgery-related complications were observed in 12 patients (16%), and complications of Grade 3b or higher were observed in 3 patients. Ninety-five PT-related complications were seen in 66 patients (88.0%), and 13 patients (17.3%) had complications of Grade 3 or higher. The median V95% (volume irradiated with 95% of the treatment planning dose) of the gross tumor volume and clinical target volume were 99.9% and 99.5%, respectively. The median D95% (dose intensity covering 95% of the target volume) of the gross tumor volume/planned dose and clinical target volume/planned dose were 99.4%, and 99.1%, respectively. CONCLUSION: The feasibility and effectiveness of space-making PT have been demonstrated via dosimetric evaluation, and our results indicate that this new strategy may potentially provide an effective and innovative treatment option for advanced APS.May 2020, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 146, 194 - 199, English, International magazineScientific journal
- Missense mutations of the RET gene have been identified in both multiple endocrine neoplasia (MEN) type 2A/B and Hirschsprung disease (HSCR: congenital absence of the enteric nervous system, ENS). Current consensus holds that MEN2A/B and HSCR are caused by activating and inactivating RET mutations, respectively. However, the biological significance of RET missense mutations in vivo has not been fully elucidated. In the present study, we introduced one MEN2B-associated (M918T) and two HSCR-associated (N394K and Y791F) RET missense mutations into the corresponding regions of the mouse Ret gene by genome editing (RetM919T , RetN396K and RetY792F ) and performed histological examinations of Ret-expressing tissues to understand the pathogenetic impact of each mutant in vivo. RetM919T/+ mice displayed MEN2B-related phenotypes, including C-cell hyperplasia and abnormal enlargement of the primary sympathetic ganglia. Similar sympathetic phenotype was observed in RetM919T/- mice, demonstrating a strong pathogenetic effect of the Ret M918T by a single-allele expression. In contrast, no abnormality was found in the ENS of mice harboring the Ret N394K or Y791F mutation. Most surprisingly, single-allele expression of RET N394K or Y791F was sufficient for normal ENS development, indicating that these RET mutants exert largely physiological function in vivo. This study reveals contrasting pathogenetic effects between MEN2B- and HSCR-associated RET missense mutations, and suggests that some of HSCR-associated RET missense mutations are by themselves neither inactivating nor pathogenetic and require involvement of other gene mutations for disease expressivity.May 2020, Development, growth & differentiation, 62(4) (4), 214 - 222, English, Domestic magazineScientific journal
- BACKGROUND: Pancreaticoduodenectomy (PD) is a standardized strategy for patients with middle and distal bile duct cancers. The aim of this study was to compare clinicopathological features of bile duct segmental resection (BDR) with PD in patients with extrahepatic cholangiocarcinoma. METHODS: Consecutive cases with extrahepatic cholangiocarcinoma who underwent BDR (n = 21) or PD (n = 84) with achievement of R0 or R1 resection in Kobe University Hospital between January 2000 and December 2016 were enrolled in the present study. RESULTS: Patients who underwent PD were significantly younger than those receiving BDR. The frequency of preoperative jaundice, biliary drainage and cholangitis was not significantly different between the two groups. The duration of surgery was longer and there was more intraoperative bleeding in the PD than in the BDR group (553 vs. 421 min, and 770 vs. 402 mL; both P<0.01). More major complications (>Clavien-Dindo IIIa) were observed in the PD group (46% vs. 10%, P<0.01). Postoperative hospital stay was also longer in that group (30 vs. 19 days, P = 0.02). Pathological assessment revealed that tumors were less advanced in the BDR group but the rate of lymph node metastasis was similar in both groups (33% in BDR and 48% in PD, P = 0.24). The rate of R0 resection was significantly higher in the PD group (80% vs. 38%, P<0.01). Adjuvant chemotherapy was more frequently administered to patients in the BDR group (62% vs. 38%, P = 0.04). Although 5-year overall survival rates were similar in both groups (44% for BDR and 51% for PD, P = 0.72), in patients with T1 and T2, the BDR group tended to have poorer prognosis (44% vs. 68% at 5-year, P = 0.09). CONCLUSIONS: BDR was comparable in prognosis to PD in middle bile duct cancer. Less invasiveness and lower morbidity of BDR justified this technique for selected patients in a poor general condition.Apr. 2020, Hepatobiliary & pancreatic diseases international : HBPD INT, 19(2) (2), 147 - 152, English, International magazine[Refereed]Scientific journal
- BACKGROUND: The albumin-bilirubin (ALBI) grade, stratified from the ALBI score, may have prognostic value in patients with hepatocellular carcinoma. We aim to evaluate the prognostic abilities of the ALBI score/grade among living-donor liver transplantation patients. METHODS: We retrospectively collected data of 81 patients who underwent living-donor liver transplant at Kobe University Hospital between June 2000 and October 2018. The efficacy of the ALBI score/grade as a prognostic factor was assessed and compared with that of the well-established Model for End-Stage Liver Disease (MELD) score. MAIN FINDINGS: Multivariate analysis indicated that recipient age (P = .003), donor age (P = .003), ALBI score ≥ -1.28 (P = .002), and ALBI grade III (P = .004) were independently associated with post-transplant survival. A high MELD score was not associated with post-transplant survival in univariate or multivariate analyses. Although there was no significant difference in the overall survival rate relative to recipient and donor age, ALBI score/grade was significantly associated with the 1- and 5-year survival rates (P = .023, P = .005). ALBI scores specifically detected fatal complications of post-transplant graft dysfunction (P = .031) and infection (P = .020). CONCLUSION: ALBI score/grade predicted patient survival more precisely than the MELD score did, suggesting that it is a more useful prognostic factor compared to the MELD score in living-donor liver transplantation cases.Apr. 2020, Transplantation proceedings, 52(3) (3), 910 - 919, English, International magazine[Refereed]Scientific journal
- PURPOSES: Resected bile duct cancers often relapse during postoperative follow-up. The aim of this study was to detect predictors of early recurrence in patients with extrahepatic bile duct cancer. METHODS: Consecutive cases (n = 162) of extrahepatic bile duct cancer in which R0 or R1 resection was achieved in Kobe University Hospital between 2000 and 2016 were divided into three groups [early recurrence (ER), within 6 months of surgery, late recurrence (LR), and no recurrence (NR)] and their clinicopathological features were compared. RESULTS: Twenty-two patients (14%) developed ER and 69 (43%) developed LR after surgery. The rates of lymph node metastasis and residual cancer status were similar in all three groups. Liver metastasis was more common in the ER group than in the LR group (59% vs. 32%, p = 0.02). ER had a significantly worse prognosis than LR and NR (7% vs. 44% vs. 85% at 1 year, p < 0.01, respectively). Multivariate analysis showed that age > 75 years, serum CA19-9 > 1008 U/ml and perineural invasion were independent predictors of early recurrence. CONCLUSIONS: High serum CA19-9 values (> 1008 U/ml) were an independent predictor of early recurrence. Neoadjuvant therapy and aggressive adjuvant therapy may be beneficial for patients who show highly elevated CA19-9 values before surgery.Apr. 2020, Surgery today, 50(4) (4), 344 - 351, English, Domestic magazine[Refereed]Scientific journal
- BACKGROUND: Liver transplantation is the most suitable treatment option available for end-stage liver disease. However, some patients require retransplantation, despite medical advances that have led to improved survival. We aimed to compile a definitive, nationwide resource of liver retransplantation data in Japan, seeking to identify the predictors of patient survival posttransplantation. METHODS: Questionnaires were sent to 32 institutions that had conducted 281 retransplantations before 2015. RESULTS: Among the 265 patients included in this study (142 pediatric cases), the average age at primary transplantation was 23 years, and retransplantation was performed after an average of 1468 days. The main indication for retransplantation was graft rejection (95 patients). Living-donor liver transplantation accounted for 94.7% of primary transplantations and 73.2% of retransplantations. Patient survival at 1, 3, or 5 years did not differ by type of transplantation but was better for pediatric (70.8%, 68.3%, and 60.1%, respectively) than for adult (57.2%, 50.4%, and 45.2%, respectively) recipients (P = 0.0003). Small-for-size syndrome, retransplantation within 365 days, and inpatient status at retransplantation were significant predictors of poor survival in pediatric cases. Retransplantation within 365 days and conditions warranting retransplantation were significant predictors of poor survival in adult patients. CONCLUSIONS: In Japan, where >70% of retransplantations are performed using living donors, the indications and timing are different from those in previous reports from other countries, while maintaining comparable survival rates. Considering technical challenges, graft failure within 365 days should be thoroughly restricted to justify the use of living donor.Apr. 2020, Transplantation, 104(4) (4), 754 - 761, English, International magazine[Refereed]Scientific journal
- The bifid pancreas is a rare anatomical variation of the pancreatic duct in which double main pancreatic ducts in the body and tail of the pancreas join at the pancreas head and drain through the major papilla. When pancreaticoduodenectomies are carried out on bifid pancreases, close attention must be paid to the reconstruction because of the possibility that there may be two pancreatic ducts that need to be reconstructed. We present a case of pancreaticoduodenectomy for the bifid pancreas and a novel technique named the 'two-in-one' method for double pancreatic duct to jejunum anastomosis. Using the two-in-one method, we anastomosed one jejunal hole to a double pancreatic duct. Pancreatic texture was normal and postoperative volumes of pancreatic juice from the two external pancreatic duct stents were 250 mL and 100 mL/day, respectively. Postoperative recovery went well although the patient needed a slightly longer hospital stay as a result of surgical site infection. This novel anastomotic technique was as simple to carry out as a normal pancreaticojejunostomy and may be useful for reconstruction of the bifid pancreas.Mar. 2020, Annals of gastroenterological surgery, 4(2) (2), 175 - 179, English, Domestic magazineScientific journal
- BACKGROUND: Sacral chordomas are rare malignant bone tumors and are often very large for complete resection. Particle therapy for these tumors, which are adjacent to the gastrointestinal tract, is restricted because the tolerance dose of the intestine is low. This study aimed to demonstrate the technical aspects and treatment results of space-making particle therapy with surgical spacer placement for sacral chordoma. We aimed to investigate the dosimetric change in the particle therapy before and after spacer placement and the safety, efficacy, and long-term outcomes of space-making particle therapy. STUDY DESIGN: Twenty-one patients with sacral chordomas who were excluded from typical particle therapy were enrolled between 2007 and 2015. Gore-Tex sheets (WL Gore & Assoc) were folded and placed between the sacral and rectum. Particle therapy with 70.4 Gy (relative biologic effectiveness) was then performed. RESULTS: The mean volume that allows 95% of the treatment plan dose of the gross tumor volume and clinical tumor volume after spacer placement was improved to 97.7% and 96.4% from preoperative values of 91.0% and 89.5%, respectively. The recurrence rate within the gross tumor volume was only 4.8%. The 4-year local progression-free survival rate was 68.4%. The 5-year overall survival rate was 100% and the adverse events were acceptable. CONCLUSIONS: Considering improvements in the dose-volume histogram after spacer placement, low recurrence rates within the gross tumor volume, good survival rates, and low incidences of side effects, treatment of sacral chordoma with space-making particle therapy shows promise.Feb. 2020, Journal of the American College of Surgeons, 230(2) (2), 207 - 215, English, International magazineScientific journal
- Aging is a grave problem in sepsis, and T cell exhaustion is the main cause of sepsis-induced immunosuppression. Sepsis- and aging-induced T cell exhaustion is related to secondary infection with a poor long-term outcome in the elderly. However, the trend, impact, and mechanism of T cell exhaustion are still unclear. Interleukin (IL)-15 improves survival rate of septic mice via its antiapoptotic effect on T cells; however, it is still unclear how IL-15 reverses prolonged T cell exhaustion in aged septic mice. The purpose of this study was to clarify the trend of sepsis-induced T cell exhaustion and whether IL-15 prevents aging-induced persistent T cell exhaustion in septic mice. Preserved cecal slurry was injected intraperitoneally into young (6-week-old) and aged mice (18-24-month-old) 4 times, to induce clinically relevant repeated sepsis. IL-15 (1.5 μg) or phosphate-buffered saline was injected subcutaneously 3 times, body weight was serially measured, and peripheral blood cells from their cheek were serially collected for 50 days. Sepsis-induced T cell exhaustion was significantly severe in aged mice than in young mice and was accompanied with decreased naive CD4 and CD8 T cells (P < 0.01) and increased expression of program death 1 on T cell (P < 0.01) and regulatory T cell population (P < 0.01). IL-15 significantly improved sepsis-induced T exhaustion, with significantly increased numbers of natural killer cells and macrophages, and significantly enhanced phagocytosis activity in aged septic mice (P < 0.05). It decreased the long-term mortality associated with sepsis survivors by improving T cell exhaustion over an extended duration and also ameliorated aging-induced persistent T cell exhaustion in septic mice.Feb. 2020, Shock (Augusta, Ga.), 53(2) (2), 228 - 235, English, International magazineScientific journal
- BACKGROUND: This study evaluated the prognosis of hepatocellular carcinoma (HCC) patients with extrahepatic metastases who can undergo hepatectomy. METHODS: A total of 32 patients who underwent hepatectomy for HCC with extrahepatic metastases, including lymph node and/or distant metastases were recruited for this study. RESULTS: Fourteen patients had lymph node metastasis only, 16 had distant metastasis only, and 2 had both metastasis types during preoperative diagnosis. The 3-year overall survival (OS) rate of all patients was 17.9%, and the median survival time (MST) was 11.8 months. Univariate analysis revealed that intrahepatic maximal tumor size, intrahepatic tumor number, and intrahepatic tumor control after hepatectomy were significant factors influencing OS (p < 0.05). Multivariate analysis revealed that independent risk factors for OS were intrahepatic maximal tumor size and intrahepatic tumor number (p < 0.05). The MST and 3-year OS rate of patients with maximal tumor size <100 mm and intrahepatic tumor number ≤2 were 39.0 months and 51.9%, respectively. CONCLUSIONS: Hepatectomy is not recommended for HCC patients with extrahepatic metastasis with ≥3 intrahepatic tumors, even when all intrahepatic tumors can be eliminated via hepatectomy. Aggressive surgery may be justified for HCC patients with ≤2 intrahepatic tumors and maximal tumor size <100 mm, irrespective of vascular invasion.2020, Digestive surgery, 37(5) (5), 411 - 419, English, International magazineScientific journal
- 金原出版(株), Jan. 2020, 手術, 74(1) (1), 49 - 56, Japanese[Refereed]Scientific journal
- (株)医学書院, Jan. 2020, 臨床外科, 75(1) (1), 56 - 61, Japanese[Refereed]
- 金原出版(株), Jan. 2020, 手術, 74(1) (1), 49 - 56, Japanese【肝胆膵外科における低侵襲手術と臓器温存手術】良〜低悪性度腫瘍に対する腹腔鏡下脾温存尾側膵切除術Scientific journal
- (株)癌と化学療法社, Dec. 2019, 癌と化学療法, 46(13) (13), 2279 - 2281, Japanese
- [Analysis of Surgical Resection for Elderly Patients with Biliary Tract Cancer].Although surgical resection is the first-line treatment for biliary tract cancer(BTC), elderly patients often have underlying diseases and decreased cardiopulmonary function that place them at a high risk of undergoing surgery. We examined the safety and efficacy of surgical resection in elderly BTC patients. Among the BTC cases that underwent surgical resection at Kobe University Hospital from 2009 to 2015, the safety and prognosis ofthose aged 75 years or older(Group 1)were compared to those younger than 75 years(Group 2)at the time ofsurgery. Fifty-two patients with perihilar cholangiocarcinoma( Bp), 29 patients with intrahepatic cholangiocarcinoma(ICC), and 40 patients with ampulla ofVater cancer(AV) were included. There was no significant difference between the 2 groups with respect to complications of Grade Ⅲor above, while surgery-related death was more common in Bp and ICC ofGroup 1. The median survival ofGroup 1 following hepatectomy for Bp and ICC(22 months)was significantly shorter than that of Group 2(40 months)(p=0.023). There was no significant difference in overall survival of Group 1 and Group 2 patients with AV(p=0.094). Surgical resection for BP and ICC for elderly patients has a higher risk of hepatectomy; therefore, precise assessment of oncologic and patient risk factors should be performed. As we can expect to achieve similar prognoses between non-elderly and elderly patients with AV, aggressive treatments should be considered for elderly patients with AV.Dec. 2019, Gan to kagaku ryoho. Cancer & chemotherapy, 46(13) (13), 2279 - 2281, Japanese, Domestic magazineScientific journal
- (公大)京都府立医科大学, Dec. 2019, 京都府立医科大学雑誌, 128(12) (12), 889 - 896, Japanese【陽子線時代の小児がんに対するQOLを重視した放射線治療における工夫】吸収性スペーサー留置を併用した小児悪性腫瘍に対する粒子線治療[Refereed]Research institution
- (株)癌と化学療法社, Dec. 2019, 癌と化学療法, 46(13) (13), 2279 - 2281, Japanese高齢胆道癌患者に対する手術成績の検討Scientific journal
- BACKGROUND: Pancreatic resection and radiotherapy are powerful tools in the multidisciplinary local treatment of pancreatic ductal adenocarcinoma (PDAC). However, 10-20% of patients with preoperatively resectable PDAC have radiographically occult metastases, which results in laparotomy without resection. This study aims to explore the utility of intraoperative near-infrared (NIR) imaging with indocyanine green (ICG) during staging laparoscopy to detect PDAC metastasis. METHODS: This prospective study will evaluate patients with radiographically non-metastatic PDAC before they undergo planned pancreatic resection or chemoradiotherapy. Enrolled patients will receive ICG intravenously (0.5 mg/kg) before the staging laparoscopy. During the staging laparoscopy, the abdominal cavity will be observed using standard white-light laparoscopic imaging and then using NIR-ICG imaging. Suspicious lesions that are detected using standard imaging and/or NIR-ICG imaging will be examined intraoperatively using frozen sections and permanent specimens. We will evaluate the benefit of NIR-ICG imaging based on its ability to identify additional liver or peritoneal lesions that were not detected during standard white-light imaging. DISCUSSION: This study will help establish the clinical utility of NIR-ICG imaging to more precisely identify metastases from radiographically non-metastatic PDAC. This approach may help avoid needless major surgery or radiotherapy. TRIAL REGISTRATION: This protocol was registered on April 1, 2017 on the UMIN Clinical Trials Registry: UMIN000025900 and February 26, 2019 on the Japan Registry of Clinical Trials: jRCT1051180076.Nov. 2019, BMC surgery, 19(1) (1), 165 - 165, English, International magazine[Refereed]Scientific journal
- BACKGROUND: Acute cholecystitis (AC) after cardiovascular surgery (CS) tends to have a serious postoperative course; however, there are few reports of AC after CS. In this study, we investigated the clinical features of AC after CS. METHOD: Of 26 patients who underwent surgery for AC after CS between 2001 and 2018 were investigated. Of these patients, the severity of AC, onset time, surgical outcomes, and postoperative pathological findings were evaluated. RESULTS: Grade III accounted for 46% (12/26) of the AC after CS patients. Gallbladder drainage did not produce sufficient outcomes in all CS cases. The postoperative hospital days of AC after CS were extended (31/21 days, P = 0.07) and the postoperative pathologic findings revealed a higher rate of gangrenous cholecystitis (88/41%, P < 0.01) than the control group. With regard to the incidence of postoperative complications, there were no differences between CS and the control group (23/24%). The mortality rate of AC after CS was 12%. CONCLUSION: Because more than 80% of CS cases involved pathologically gangrenous cholecystitis, it may be necessary to perform early surgery for AC after CS, even when the severity of AC is Grade III.Nov. 2019, Journal of hepato-biliary-pancreatic sciences, 26(11) (11), 503 - 509, English, Domestic magazine[Refereed]Scientific journal
- (株)医学書院, Oct. 2019, 臨床外科, 74(11) (11), 239 - 243, Japanese
- BACKGROUND: This study aimed to evaluate the clinical relevance of hepatectomy for Barcelona Clinic Liver Cancer (BCLC) stages B and C advanced hepatocellular carcinoma (HCC). METHODS: A total of 314 patients (149 and 165 BCLC stages B and C, respectively) who underwent hepatectomy were included. Complete hepatectomy (without residual tumors after hepatectomy) and reductive hepatectomy (apparent residual tumors after hepatectomy) were performed for 212 and 102 patients, respectively. Short-term operative and postoperative outcomes, as well as long-term outcomes, were evaluated. RESULTS: The median survival times of patients with stage B disease undergoing complete hepatectomy and reductive hepatectomy were 48.9 and 20.1 months, respectively (p = 0.0075), whereas those of patients with stage C disease were 19.5 and 17.6 months, respectively (p = 0.0140). The 3-year overall survival rates of patients with stage B disease undergoing reductive hepatectomy with and without subsequent local treatments after surgery were 47.5% and 0%, respectively, whereas those of patients with stage C diseases were 18.6% and 0%, respectively. CONCLUSIONS: Survival benefits are obvious for both BCLC stages B and C HCC when complete hepatectomy can be performed safely. Reductive hepatectomy is also acceptable for BCLC stages B and C when subsequent local treatment for remnant liver tumors can be performed safely after reductive hepatectomy. Without subsequent local treatment, reductive hepatectomy has little clinical relevance. Thus, a cautious approach to patient selection is required for this aggressive strategy.Oct. 2019, World journal of surgery, 43(10) (10), 2571 - 2578, English, International magazine[Refereed]Scientific journal
- BACKGROUND: The use of surgical metal clips is crucial for ligating vessels in various operations. The currently available metal clips have several drawbacks; they are permanent and interfere with imaging techniques such as computed tomography (CT) or magnetic resonance (MR) imaging and carry the potential risk of endo-clip migration. We recently developed a novel magnesium (Mg) alloy for biodegradable clips that reduces artifacts on CT imaging. This study aimed to examine the tolerance, biodegradability, and biocompatibility of the Mg alloy clips compared with those of standard titanium (Ti) clips in hepatectomy. METHODS: Thirty Wistar rats were divided into two groups based on the clip used (groups A and B). The vascular pedicle, including hepatic artery, portal vein, bile duct, and hepatic vein of the left lateral lobe, was ligated with the Ti clip in group A or the Mg alloy clip in group B, and then the left lateral lobe was removed. The rats were sacrificed at 1, 4, 12, 24, and 36 weeks after surgery. Clinical and histological evaluations were performed. Absorption rate was calculated by measuring the clip volume. RESULTS: Although the Mg alloy clips showed biodegradability over time, there were no significant differences in the serum concentration of Mg between the two groups. The remaining volume ratio of Mg alloy clips was 95.5, 94.3, 80.0, 36.2, and 16.7% at 1, 4, 12, 24, and 36 weeks, respectively. No side effects occurred. Most of the microscopic changes were similar in both groups. CONCLUSIONS: The new biodegradable Mg alloy clips are safe and feasible in vessel ligation for hepatectomy in a rat model and reduce artifacts in CT imaging compared with the standard Ti clips.Sep. 2019, BMC surgery, 19(1) (1), 130 - 130, English, International magazine[Refereed]Scientific journal
- (一社)日本小児血液・がん学会, Sep. 2019, 日本小児血液・がん学会雑誌, 56(2) (2), 148 - 152, Japanese[Refereed]
- AIMS: The present study aimed to systematically compare clinicopathological and genetic features between keratin 19 (K19)-expressing hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA). METHODS AND RESULTS: Consecutive cases of HCC (n = 430) were classified into K19+ and K19- using immunohistochemistry. ICCA cases were also separated into small-(S-iCCA; n = 36) and large-duct types (n = 22) based on recently proposed criteria, with the former being used in the present study. Mutational hot-spots in TERT, CTNNB1, KRAS and IDH1 were sequenced. Twenty-six cases (6%) of HCC expressed K19. K19+ HCC was more strongly associated with chronic hepatitis B than K19- HCC and S-iCCA (46% versus 17% and 6%; both P < 0.001). Lymph node metastasis was observed in K19+ HCC (8%) and S-iCCA (22%), but was exceptional in K19- HCC (1%). K19+ HCC had TERT promoter mutations less frequently than K19- HCC (31% versus 59%; P = 0.022), and lacked alterations in KRAS and IDH1. CTNNB1 mutations were similarly observed in K19+ and K19- HCC (23% and 19%, respectively), but rare in S-iCCA (3%). The postoperative survival curve of K19+ HCC was almost identical to that of S-iCCA in the first 5 years (approximately 50% at 5 years), and significantly worse than that of K19- HCC (P = 0.040). Extrahepatic recurrence was more common in K19+ HCC (50%) and S-iCCA (35%) than in K19- HCC (15%) (P = 0.001). CONCLUSIONS: Although K19+ HCC and S-iCCA showed similar biological behaviours, they did not share any driver gene mutations, suggesting the possible involvement of epigenetic alterations in the iCCA-like features of K19+ HCC.Sep. 2019, Histopathology, 75(3) (3), 385 - 393, English, International magazine[Refereed]Scientific journal
- BACKGROUND AND AIM: Chronic pancreatitis is a risk factor for pancreatic cancer. Pancreatic calcification is a characteristic of chronic pancreatitis; however, its significance for intraductal papillary mucinous neoplasm (IPMN) oncogenesis remains unknown. Therefore, we investigated the relationship between pancreatic calcification and invasive IPMN. METHODS: This study included 157 patients who underwent resection for IPMN between April 2001 and October 2016 (intraductal papillary mucinous adenoma, n = 76; noninvasive intraductal papillary mucinous carcinoma [IPMC], n = 32; and invasive IPMC, n = 49). We divided the subjects on the basis of the presence/absence of pancreatic calcification on preoperative computed tomography (CT). The factors associated with pancreatic calcification were investigated in univariate analyses. Then, multivariate logistic regression analyses of the relationship between pancreatic calcification and invasive IPMC (after adjusting for clinical or imaging characteristics) were conducted. RESULTS: Preoperative CT revealed pancreatic calcification in 17.2% (27/157) of the resected IPMN. In the univariate analyses, jaundice, high serum carbohydrate antigen 19-9 levels, and invasive IPMC were significantly associated with pancreatic calcification (4/27 [14.8%] vs 4/130 [3.1%], 0.01; 12/27 [44.4%] vs 31/130 [23.8%], 0.03; and 15/27 [55.6%] vs 34/130 [26.2%], 0.001, respectively). Pancreatic calcification was significantly associated with invasive IPMC (multivariate odds ratio = 2.88, 95% confidence interval [95% CI] = 1.15-7.21, 0.03, adjusted for clinical characteristics; odds ratio = 5.50, 95% CI = 1.98-15.3, 0.001, adjusted for imaging characteristics). CONCLUSIONS: Pancreatic calcification on CT is associated with invasive IPMC. Pancreatic calcification might be a predictor of invasive IPMC.Sep. 2019, Journal of gastroenterology and hepatology, 34(9) (9), 1648 - 1655, English, International magazine[Refereed]Scientific journal
- We recently experienced cases of pancreatobiliary-type intraductal papillary mucinous neoplasms (PB-IPMNs) with imaging features resembling pancreatic ductal adenocarcinomas (PDACs), and histologic appearance of purely pancreatobiliary morphology and highly distorted papillary growth, which led to the present study aiming to systematically investigate PB-IPMNs in comparison with PDACs. Surgical cases of PB-IPMNs (n = 31) and PDACs (n = 24) were examined. PB-IPMNs were classified into monotypic tumors (n = 12; 39%) consisting of entirely high-grade pancreatobiliary-type neoplastic cells and polytypic cases (n = 19; 61%) associated with components of low-grade dysplasia and/or other histologic types (eg, gastric, intestinal, or oncocytic types). Clinically, monotypic PB-IPMNs less commonly had dilatation of the ampullary orifice (0% versus 74%) and mucin hypersecretion (17% versus 89%) than did polytypic cases. In most cases of monotypic PB-IPMNs, cystic dilatation of the lesional ducts was less obvious on imaging; therefore, 33% were radiologically diagnosed as PDACs. Histologically, intraductal tumors in monotypic cases showed a highly complex papillary architecture with tubular/cribriform glands and irregular branching, and all these cases were associated with invasive malignancy. GNAS mutations were detected in polytypic PB-IPMNs (6/19; 32%), but there were no GNAS mutations in monotypic cases. The recurrence-free survival of patients with monotypic PB-IPMN or PDAC was similar and significantly worse than that of patients with polytypic PB-IPMN. In conclusion, some cases of monotypic PB-IPMNs lacked the classic characteristics of IPMNs and shared features with PDACs, raising the possibility that these cases may be better classified as a papillary variant of PDACs rather than IPMNs.Sep. 2019, Human pathology, 91, 26 - 35, English, International magazine[Refereed]Scientific journal
- AIMS: To investigate whether genetic or inflammatory pro-oncogenic factors are relevant to the increased risk of gallbladder cancers in patients with pancreaticobiliary maljunction (PBM). METHODS AND RESULTS: Mutations in KRAS exon 2 were examined by a highly sensitive, droplet digital PCR platform using surgically resected specimens of PBM-associated (n = 31) and non-associated gallbladder cancers (n = 49). The tissue expression of IL-6 and IL-33, which are suspected to promote biliary carcinogenesis, was analysed by quantitative real-time PCR and in-situ hybridisation. The incidence of KRAS mutations was similarly low in PBM-associated (five of 32 cases; 16%) and non-associated cancers (four of 49 cases; 8%) (P = 0.272). The tissue expression of IL-33 mRNA, but not IL-6 mRNA, was significantly higher in PBM-associated gallbladder cancers than in gallbladder cancers without PBM (P = 0.004). A similar degree of IL-33 overexpression was also observed in the background non-cancerous mucosa in cases of PBM-associated gallbladder cancers, and was significantly greater than that in PBM cases with cholecystitis alone (P < 0.001). The results of in-situ hybridisation indicated that the source of IL-33 production in PBM-associated carcinomas was the endothelium, cancer cells and non-neoplastic biliary epithelium. In a combined PBM-associated and non-associated cohort, IL-33 overexpression in gallbladder cancers correlated with less aggressive features (e.g. a lower pT stage and longer overall survival), similar to recently reported findings on large-duct cholangiocarcinomas. CONCLUSIONS: KRAS mutations do not appear to be associated with a high risk of malignancy in PBM, while IL-33 overexpression may provide a pro-oncogenic microenvironment in the gallbladder mucosa of patients with PBM.Sep. 2019, Histopathology, 75(3) (3), 365 - 375, English, International magazine[Refereed]Scientific journal
- INTRODUCTION: In-vivo fluorescence imaging techniques using indocyanine green (ICG) to identify liver tumours and hepatic segment boundaries have been recently developed. The purpose of this study is to evaluate the efficacy of fusion ICG-fluorescence imaging for navigation during hepatectomy. METHODS AND ANALYSIS: This will be an exploratory single-arm clinical trial; patients with liver tumours will undergo hepatectomy using the ICG-fluorescence imaging system. In total, 110 patients with liver tumours scheduled for elective hepatectomy will be included in this study. Preoperatively, ICG will be intravenously injected at a dose of 0.5 mg/kg body weight within 2 days. To detect liver tumours intraoperatively, the hepatic surface will be initially observed using the ICG-fluorescence imaging system. After identifying and clamping the portal pedicle corresponding to the hepatic segments, including the liver tumours to be resected, additional ICG will be injected intravenously at a dose of 0.5 mg/kg body weight to identify the boundaries of the hepatic segments. The primary outcome measure will be the success or failure of the ICG-fluorescence imaging system in identifying hepatic segments. The secondary outcomes will be the success or failure in identifying liver tumours, liver function indicators, operative time, blood loss, rate of postoperative complications and recurrence-free survival. The findings obtained through this study are expected to help to establish the utility of ICG-fluorescence imaging systems, and therefore contribute to prognostic outcome improvements in patients undergoing hepatectomy for various causes. ETHICS AND DISSEMINATION: The protocol has been approved by the Kobe University Clinical Research Ethical Committee. The findings of this study will be disseminated widely through peer-reviewed publications and conference presentations. TRIAL REGISTRATION NUMBER: UMIN000031054 and jRCT1051180070.Aug. 2019, BMJ open, 9(8) (8), e030233, English, International magazine[Refereed]Scientific journal
- INTRODUCTION: Multimodal treatment prolongs the survival of patients with biliary tract cancer (BTC). However, the chemotherapy choices for this disease are few, and completing each chemotherapy session is important. Adjuvant chemotherapy has been attempted for BTC, but has only had a 75% completion rate. Body weight loss and cholangitis are reasons for the interruption of chemotherapy. Previous reports suggested that nutritional intervention with omega-3 fatty acids maintained body weight and improved the completion rate for chemotherapy. Moreover, omega-3 fatty acids have an anti-inflammatory effect. Therefore, we theorised that omega-3 fatty acids would improve the completion rate of adjuvant chemotherapy in patients with BTC. The aim of this study is thus to evaluate the effectiveness of omega-3 fatty acids for patients planning adjuvant chemotherapy for BTC. METHOD AND ANALYSIS: This study is a single-centre, open-label, single-arm, historically controlled study with a planned enrolment of 55 participants. Protocol treatment consists of four courses of S-1 adjuvant chemotherapy and an oral omega-3 fatty acid pharmaceutic adjuvant (LOTRIGA 2 g (Takeda Pharmaceutical Co.)), which includes 2 g of omega-3 fatty acids from day 1 until day 168 of the treatment period. The primary endpoint is the completion rate of four total courses of S-1. Secondary endpoints are postoperative cholangitis, time to recurrence or distant metastasis, changes in nutritional index, changes in the lymphocyte blast transformation test induced by phytohaemagglutinin, and concanavalin A and diamine oxidase serum activity during adjuvant chemotherapy. All adverse events will be evaluated. ETHICS AND DISSEMINATION: This protocol was approved by the Institutional Review Board of Kobe University Hospital. The findings from this study will be presented at national and international conferences and published in peer-reviewed journals. TRIAL REGISTRATION NUMBER: UMIN000031247.Aug. 2019, BMJ open, 9(8) (8), e029915, English, International magazine[Refereed]Scientific journal
- Aug. 2019, Journal of surgical oncology, 120(2) (2), 214 - 222, English, International magazine[Refereed]Scientific journal
- BACKGROUND: The optimal treatment for isolated local recurrence (ILR) of pancreatic adenocarcinoma (PDAC) after surgical resection remains unclear. This study aimed to evaluate the safety and efficacy of proton radiotherapy (PRT) for ILR of PDAC after surgery. METHODS: The medical records of patients with ILR of PDAC after surgery who underwent proton beam therapy between 2011 and 2015 at Hyogo Ion Beam Medical Center were retrospectively studied. RESULTS: The study analyzed 30 patients (14 women and 16 men) with a median age of 65 years (range 38-81 years) who had initially undergone pancreatoduodenectomy (n = 23) or distal pancreatectomy (n = 7) for their primary tumors. Upon ILR, PRT was administered with a median total cumulative dose of 67.5 gray equivalent (GyE) (range 50-67.5 GyE) using 19 to 25 fractions. For 25 patients, concurrent chemotherapy was administered using gemcitabine (n = 18) or S-1 (n = 7). Four patients (13.3%) experienced acute grade ≥ 3 gastrointestinal toxicities. After a median follow-up period of 17.6 months (range 2.1-50.4 months), 23 patients had experienced tumor progression and 10 had died. Nine patients (30%) experienced local tumor progression. The median overall, progression-free, and local progression-free survival rates were 26.1, 12.3, and 41.2 months, respectively. Pre-PRT serum levels of cancer antigen 19-9 higher than 100 U/mL and duke pancreatic monoclonal antigen type 2 higher than 150 U/mL were significantly associated with shorter progression-free survival rates. CONCLUSIONS: Proton radiotherapy for ILR of PDAC after surgery is well tolerated and produces good locoregional control and should be considered for eligible patients.Aug. 2019, Annals of surgical oncology, 26(8) (8), 2587 - 2594, English, International magazine[Refereed]Scientific journal
- (株)北隆館, Jul. 2019, BIO Clinica, 34(7) (7), 691 - 696, Japanese【肝炎・肝癌】肝細胞癌に対する外科治療の最前線Scientific journal
- INTRODUCTION: Bile leak is still a major complication after liver resection to be improved. To intraoperatively detect this adverse complication, leak test is commonly performed after hepatic resection. However, by the conventional leak test, it is often difficult to know whether the test reagent reaches to intrahepatic bile duct near cut surface of liver with adequate volume and pressure to identify the existence of bile leak. Thus, in order to perform leak test more accurately, this study aims to evaluate the efficacy and safety of the leak test using contrast-enhanced intraoperative ultrasonic cholangiography (CE-IOUSC), which was reported by our group as a procedure for detection of bile duct. METHODS AND ANALYSIS: The current study is a non-randomised, prospective, off-label, single-arm clinical trial for patients who undergo liver resection. A total of 100 patients will be enrolled. After completion of liver resection, the leak test is performed with CE-IOUSC using Sonazoid as a contrast agent to visualise dye injection into the intrahepatic bile duct. The primary endpoint is the success of the leak test, defined as clear visualisation of intrahepatic bile duct around cut surface by ultrasonography that indicates enough volume of dye injection. Secondary endpoints are postoperative bile leak and all adverse events related to CE-IOUSC. The findings obtained through this study will establish this procedure to assist surgeons for adequately performing the leak test, precisely detecting intraoperative biliary leak strictly and reducing postoperative bile leak. ETHICS AND DISSEMINATION: The protocol is approved by Institutional Review Boards of Kobe University Hospital (No.290069). Our findings will be widely disseminated through conference presentations and peer-reviewed publications. TRIAL REGISTRATION NUMBER: UMIN000031236 and jRCTs051180027.Jun. 2019, BMJ open, 9(6) (6), e029330, English, International magazine[Refereed]Scientific journal
- 金原出版(株), Jun. 2019, 手術, 73(7) (7), 959 - 969, Japanese
- Although intracholecystic papillary neoplasms (ICPNs) have been increasingly recognized, their features remain unclear because of the lack of standardized definition. This study aimed to elucidate clinicopathologic and genetic features of ICPNs using stringent diagnostic criteria. On the basis of the recently proposed criteria, gallbladder neoplasms showing delicate papillary growth were diagnosed as ICPNs, while polypoid papillary adenocarcinomas arranged in a complex architecture were categorized as papillary gallbladder cancers (GBCs). Clinicopathologic features were compared among ICPNs (n=7), papillary GBCs (n=24), and nonpapillary GBCs (n=44). Whole-exome and validation Sanger sequencing was also conducted. Gross mucin hypersecretion was detected in 3/7 ICPNs (43%), 1/24 papillary GBCs (4%), and 1/44 nonpapillary GBCs (2%) (P<0.001). All patients with ICPN lacked lymphovascular invasion and nodal metastasis, while these features were occasionally observed in patients with papillary or nonpapillary GBC (13% to 59%). ICPNs were less advanced than papillary and nonpapillary GBCs (P<0.001) with all cases of ICPNs being recurrence-free. Whole-exome and Sanger sequencing identified somatic mutations in STK11 (a causative gene of Peutz-Jegher syndrome; n=3), CTNNB1 (n=2), and APC (a gene of familial adenomatous polyposis; n=1) in ICPNs, while those alterations were exceptional in papillary and nonpapillary GBCs. ICPNs more commonly showed cytoplasmic and/or nuclear expressions of β-catenin than papillary and nonpapillary GBCs. In conclusion, the histology-based classification of gallbladder papillary neoplasms is useful for identifying ICPNs that share clinicopathologic features with the pancreatic counterpart. ICPNs meeting the criteria were genetically distinct from papillary and nonpapillary GBCs, with STK11, CTNNB1, and APC being identified as major driver genes for ICPNs.Jun. 2019, The American journal of surgical pathology, 43(6) (6), 783 - 791, English, International magazine[Refereed]Scientific journal
- Last, May 2019, Adv Radiat Oncol., 4(4) (4), 729 - 737, EnglishFirst-In-Human Phase 1 Study of a Nonwoven Fabric Bioabsorbable Spacer for Particle Therapy: Space-Making Particle Therapy (SMPT).[Refereed]Scientific journal
- Medullary thyroid carcinoma (MTC) develops from hyperplasia of thyroid C cells and represents one of the major causes of thyroid cancer mortality. Mutations in the cysteine-rich domain (CRD) of the RET gene are the most prevalent genetic cause of MTC. The current consensus holds that such cysteine mutations cause ligand-independent dimerization and constitutive activation of RET. However, given the number of the CRD mutations left uncharacterized, our understanding of the pathogenetic mechanisms by which CRD mutations lead to MTC remains incomplete. We report here that RET(C618F), a mutation identified in MTC patients, displays moderately high basal activity and requires the ligand for its full activation. To assess the biological significance of RET(C618F) in organogenesis, we generated a knock-in mouse line conditionally expressing RET(C618F) cDNA by the Ret promoter. The RET(C618F) allele can be made to be Ret-null and express mCherry by Cre-loxP recombination, which allows the assessment of the biological influence of RET(C618F) in vivo. Mice expressing RET(C618F) display mild C cell hyperplasia and increased numbers of enteric neurons, indicating that RET(C618F) confers gain-of-function phenotypes. This mouse line serves as a novel biological platform for investigating pathogenetic mechanisms involved in MTC and enteric hyperganglionosis.May 2019, Genesis (New York, N.Y. : 2000), 57(5) (5), e23292, English, International magazine[Refereed]Scientific journal
- (株)癌と化学療法社, Apr. 2019, 癌と化学療法, 46(4) (4), 775 - 777, Japanese
- OBJECTIVES: Pancreatic juice cytology (PJC) for intraductal papillary mucinous neoplasm (IPMN) is a possible tool to enhance preoperative diagnostic ability by improving risk classification for malignant IPMN, but its efficacy is controversial. This study evaluated the efficacy of PJC for risk classification according to international guidelines. METHODS: We retrospectively analyzed 127 IPMN patients who underwent endoscopic retrograde cholangiopancreatography (ERCP) preoperatively. PJC was performed in 125 of the 127 cases. High-risk stigmata (HRS, n = 57), worrisome features (WF, n = 64), and other characteristics (n = 6) were classified according to the 2017 international guidelines. RESULTS: Among the 127 IPMN patients, 71 (55.9%) had malignant IPMN (invasive and non-invasive intraductal papillary mucinous carcinoma). The accuracy of WF for classifying malignant IPMN was increased by the addition of PJC, but the accuracy of HRS was not (WF to WF + PJC: 33.1% [42/127] to 48.8% [61/125], HRS to HRS + PJC: 65.4% [83/127] to 52.8% [66/125]). Post-ERCP pancreatitis (PEP) occurred in 32 (25.2%) of 127 IPMN patients. Severe PEP was not detected. Significant risk factors for PEP were female sex, obesity, and endoscopic naso-pancreatic drainage (ENPD) (P = .03, P = .0006, and P = .02, respectively). In patients with ENPD tube placement, a main pancreatic duct size of <5 mm was a significant risk factor for PEP (P = .02). CONCLUSION: PJC could increase the accuracy of WF for classifying malignant IPMN. The additive effect of PJC for risk classification may be limited, however, and it is not recommended for all IPMN cases due to the high frequency of PEP.Apr. 2019, Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 19(3) (3), 424 - 428, English, International magazine[Refereed]Scientific journal
- BACKGROUND: Carbohydrate antigen (CA) 19-9 levels after resection are considered to predict prognosis; however, the significance of decreased CA19-9 levels after neoadjuvant therapy has not been clarified. This study aimed to define the prognostic significance of decreased CA19-9 levels after neoadjuvant therapy in patients with pancreatic adenocarcinoma. METHODS: Between 2001 and 2012, 240 consecutive patients received neoadjuvant therapy and subsequent resection at seven high-volume institutions in Japan. These patients were divided into three groups: Normal group (no elevation [≤37 U/ml] before and after neoadjuvant therapy), Responder group (elevated levels [> 37 U/ml] before neoadjuvant therapy but decreased levels [≤37 U/ml] afterwards), and Non-responder group (elevated levels [> 37 U/ml] after neoadjuvant therapy). Analyses of overall survival and recurrence patterns were performed. Uni- and multivariate analyses were performed to clarify the clinicopathological factors influencing overall survival. The initial metastasis sites were also evaluated in these groups. RESULTS: The Responder group received a better prognosis than the Non-responder group (3-year overall survival: 50.6 and 41.6%, respectively, P = 0.026), but the prognosis was comparable to the Normal group (3-year overall survival: 54.2%, P = 0.934). According to the analysis of the receiver operating characteristic curve, the CA19-9 cut-off level defined as no elevation after neoadjuvant therapy was ≤103 U/ml. The multivariate analysis revealed that a CA19-9 level ≤ 103 U/ml, (P = 0.010, hazard ratio: 1.711; 95% confidence interval: 1.133-2.639), tumor size ≤27 mm (P = 0.040, 1.517; (1.018-2.278)), a lack of lymph node metastasis (P = 0.002, 1.905; (1.276-2.875)), and R0 status (P = 0.045, 1.659; 1.012-2.627) were significant predictors of overall survival. Moreover, the Responder group showed a lower risk of hepatic recurrence (18%) compared to the Non-responder group (31%), though no significant difference in loco-regional, peritoneal or other distant recurrence were observed between groups (P = 0.058, P = 0.700 and P = 0.350, respectively). CONCLUSIONS: Decreased CA19-9 levels after neoadjuvant therapy predicts a better prognosis, with low incidence of hepatic recurrence after surgery.Mar. 2019, BMC cancer, 19(1) (1), 252 - 252, English, International magazine[Refereed]Scientific journal
- (一社)日本外科学会, Mar. 2019, 日本外科学会雑誌, 120(2) (2), 177 - 182, Japanese
- (一財)日本消化器病学会, Mar. 2019, 日本消化器病学会雑誌, 116(臨増総会) (臨増総会), A405 - A405, Japanese
- ADP-ribosylation factor-like 4c (ARL4C) is identified as a small GTP-binding protein, which is expressed by Wnt and EGF signaling and plays an important role in tubulogenesis of cultured cells and the ureters. ARL4C is little expressed in adult tissues, but it is highly expressed in lung cancer and colorectal cancer and shown to represent a molecular target for cancer therapy based on siRNA experiments. This study revealed that ARL4C is highly expressed in primary hepatocellular carcinoma (HCC) tumors and colorectal cancer liver metastases, and that ARL4C expression is associated with poor prognosis for these cancers. Chemically modified antisense oligonucleotides (ASO) against ARL4C effectively reduced ARL4C expression in both HCC and colorectal cancer cells and inhibited proliferation and migration of these cancer cells in vitro ARL4C ASOs decreased the PIK3CD mRNA levels and inhibited the activity of AKT in HCC cells, suggesting that the downstream signaling of ARL4C in HCC cells is different from that in lung and colon cancer cells. In addition, subcutaneous injection of ARL4C ASO was effective in reducing the growth of primary HCC and metastatic colorectal cancer in the liver of immunodeficient mice. ARL4C ASO accumulated in cancer cells more efficiently than the surrounding normal cells in the liver and decreased ARL4C expression in the tumor. These results suggest that ARL4C ASO represents a novel targeted nucleic acid medicine for the treatment of primary and metastatic liver cancers.Mar. 2019, Molecular cancer therapeutics, 18(3) (3), 602 - 612, English, International magazine[Refereed]Scientific journal
- (株)癌と化学療法社, Feb. 2019, 癌と化学療法, 46(2) (2), 315 - 317, Japanese
- BACKGROUND: Survival after surgery for pancreatic adenocarcinoma (PA) is poor and heterogeneous, even for curative (R0) resection. Serum carbohydrate antigen (CA) 19-9 levels are important prognostic markers for resected PA. However, sustained elevation of CA19-9 in association with the patterns of recurrence has been rarely investigated. METHODS: Patients who underwent R0 resection (n = 539) were grouped according to postoperative serum CA19-9 levels (Group E: sustained elevation; Group N: no elevation). Clinicopathological factors, patterns of recurrence, and survival were compared between the groups. RESULTS: Group E (n = 159) had significantly shorter median overall survival (17.1 vs. 35.4 months, p < 0.0001) than Group N (n = 380). Postoperative CA19-9 elevation was a significant independent predictor of poor survival in multivariate analysis (hazard ratio 1.98, p < 0.0001). The rate of hepatic recurrence in Group E was 2.6-fold higher than in Group N (45% vs. 17%, p < 0.0001). Postoperative CA19-9 elevation was a strongest independent predictor of primary hepatic recurrence (p < 0.0001) by a multiple regression model. Loco-regional, peritoneal, and other distant recurrence did not differ between the groups. The extent of preoperative CA19-9 elevation was correlated sustained elevation of CA19-9 after surgery (p < 0.0001) and primary hepatic recurrence (p = 0.0019). CONCLUSIONS: Sustained CA19-9 elevation was strong predictor of primary hepatic recurrence and short survival in cases of R0 resection for PA.Feb. 2019, World journal of surgery, 43(2) (2), 634 - 641, English, International magazine[Refereed]Scientific journal
- AIM: To evaluate the clinical significance of lateral pelvic lymph node (LLN) size in predicting pathological metastasis and prognosis in rectal cancer treated with preoperative chemoradiotherapy (CRT) followed by surgery. PATIENTS AND METHODS: Fifty-two patients with rectal cancer who underwent curative surgery after preoperative CRT were included. Fifteen patients underwent total mesorectal excision (TME) alone, while 37 patients underwent TME with LLN dissection for clinical LLN metastasis. RESULTS: Pathological metastasis was identified in seven (2.6%) out of 270 resected LLNs in six (16.2%) out of 37 patients. The cut-off value of the short-axis diameter was 7.0 mm before and 6.0 mm after CRT. The 5-year recurrence-free survival rate was significantly higher in patients with LLNs <7.0 mm than in those with LLNs ≥7.0 mm (85.7% versus 56.8%, p=0.038). CONCLUSION: Short-axis diameter of LLNs of 7.0 mm seems to be an optimal cut-off value before CRT for predicting pathological metastasis and prognosis.Feb. 2019, Anticancer research, 39(2) (2), 993 - 998, English, International magazine[Refereed]Scientific journal
- BACKGROUND: Lactate production is exacerbated by surgical stress. We sought to determine whether branched-chain amino acid (BCAA) supplementation could decrease blood lactate levels in patients undergoing hepatectomy. METHODS: A total of 275 consecutive patients who underwent hepatectomy of ≥2 segments were retrospectively reviewed. Blood lactate levels in patients treated with BCAA supplementation before hepatectomy (December 2011 to December 2016) were compared with levels in patients who were not pretreated (January 2008 to November 2011). RESULTS: Postoperative lactate levels were significantly lower in patients who received preoperative BCAA supplementation than in those who did not (2.6 vs 3.4 mmol/L; P < .001). Intraoperative blood lactate levels, which were evaluated after induction of general anesthesia, were also lower in those who received BCAA supplementation than in those who did not (1.1 vs 1.5 mmol/L, respectively; P < .001). A multiple regression analysis revealed that preoperative BCAA supplementation was independently associated with decreased postoperative and intraoperative lactate levels (P = .030 and P < .001, respectively). CONCLUSION: Preoperative BCAA supplementation decreased intraoperative and postoperative blood lactate levels in patients undergoing major hepatectomy.Feb. 2019, JPEN. Journal of parenteral and enteral nutrition, 43(2) (2), 220 - 225, English, International magazine[Refereed]Scientific journal
- BACKGROUND: Growing evidence has suggested that intrahepatic cholangiocarcinoma (iCCA) can be classified into small- and large-duct types. The present study aimed to elucidate how large-duct iCCA is similar and dissimilar to perihilar cholangiocarcinoma (pCCA). METHODS: The study cohort consisted of iCCA (n = 58) and pCCA (n = 44). After iCCA tumors were separated into small- (n = 36) and large-duct (n = 22) types based on our histologic criteria, genetic statuses of the three types of neoplasms were compared. Locations of iCCA were plotted on a three-dimensional image and their distances from the portal bifurcation were measured. RESULTS: Large-duct iCCA was distinct from small-duct iCCA in terms of frequency of bile duct reconstruction required, perineural infiltration, and survival, with these features more similar to pCCA. Large-duct iCCA and pCCA more frequently had the loss of SMAD4 expression and MDM2 amplifications than small-duct iCCA, whereas the loss of BAP1 expression and IDH1 mutations were mostly restricted to small-duct iCCA. From imaging analysis, most tumors of large-duct iCCA were present around the second branches of the portal vein. CONCLUSION: Large-duct type iCCA shared the molecular features with pCCA, and it may be reasonable to expand the definition of pCCA to include cancers originating from the second bile duct branches.Feb. 2019, HPB : the official journal of the International Hepato Pancreato Biliary Association, 21(2) (2), 226 - 234, English, International magazine[Refereed]Scientific journal
- (株)アークメディア, Jan. 2019, 肝・胆・膵, 78(1) (1), 79 - 86, Japanese【膵神経内分泌腫瘍-診断と治療のパラダイムシフト-】 外科治療 膵神経内分泌腫瘍の外科治療前にわかる予後予測因子[Refereed]
- (株)癌と化学療法社, Dec. 2018, 癌と化学療法, 45(13) (13), 2214 - 2216, Japanese[Refereed]
- (株)癌と化学療法社, Dec. 2018, 癌と化学療法, 45(13) (13), 2408 - 2410, Japanese[Refereed]
- Dec. 2018, Am J Surg Pathol, 42(12) (12), 1674 - 1685, EnglishRecurrent Mutations in APC and CTNNB1 and Activated Wnt/β-catenin Signaling in Intraductal Papillary Neoplasms of the Bile Duct: A Whole Exome Sequencing Study[Refereed]Scientific journal
- Nov. 2018, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 33, 537 - 537, EnglishThe risk and benefit of preoperative pancreatic juice cytology under ERCP in patients with IPMNs
- Nov. 2018, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 33, 194 - 194, EnglishSignificance of pancreatic calcification on preoperative CT image of intraductal papillary mucinous neoplasm
- Nov. 2018, Anticancer Res, 38(11) (11), 6445 - 6452, EnglishNovel Extracorporeal Hemoperfusion System for Hepatic Arterial Infusion of Cisplatin[Refereed]Scientific journal
- BACKGROUND: Progression of portal vein tumor thrombus directly affects the prognosis and treatment for patients with hepatocellular carcinoma; there are no data on the growth velocity of portal vein tumor thrombus. We analyzed the growth velocity of portal vein tumor thrombus and its risk factors to propose the best timing of surgical treatment for hepatocellular carcinoma with portal vein tumor thrombus. METHODS: We retrospectively collected data on 57 hepatocellular carcinoma patients with portal vein tumor thrombus who underwent computed tomography twice preoperatively and hepatectomy between 2005 and 2015. To calculate the growth velocity of portal vein tumor thrombus, migration lengths of portal vein tumor thrombus were divided by the number of days. To identify risk factors for rapid growth of portal vein tumor thrombus, patients were classified according to the velocity: rapid (≥ 1.0 mm/day, n = 23) and slow (< 1.0 mm/day, n = 34). RESULTS: Median survival times of patients with portal vein tumor thrombus that invaded the ipsilateral second portal branch, ipsilateral first portal branch, and portal trunk were 42.9, 11.7, and 12.3 months, respectively. The average growth velocity of portal vein tumor thrombus was 0.9 ± 1.0 mm/day. Median estimated times required from ipsilateral second portal branch to ipsilateral first portal branch and ipsilateral first portal branch to portal trunk were 8.2 and 11.5 days, respectively. Liver fibrosis, alpha-fetoprotein, and extent of portal vein tumor thrombus were independent risk factors for rapid progression of portal vein tumor thrombus. Proteins induced by vitamin K absence or antagonist II, extent of portal vein tumor thrombus, and liver fibrosis, not rapid growth of portal vein tumor thrombus, were independent prognostic factors. CONCLUSION: An understanding of the rapid progression of portal vein tumor thrombus and its risk factors can be helpful in deciding an appropriate timing of surgical treatment for hepatocellular carcinoma with portal vein tumor thrombus.Nov. 2018, Surgery, 164(5) (5), 1014 - 1022, English, International magazine[Refereed]Scientific journal
- PURPOSE: This study was designed to assess the potential role of the preoperative serum level of elastase 1 as a risk factor for recurrence in patients with resectable well-differentiated pancreatic neuroendocrine neoplasms (PanNETs). METHODS: Preoperative serum elastase 1 levels were measured in 53 patients with PanNETs who underwent complete tumor resection in two tertiary referral centers between January 2004 and June 2017. The preoperative elastase 1 levels were correlated with clinicopathological characteristics, including tumor recurrence and recurrence-free survival. RESULTS: The median elastase 1 level was 96 ng/dL (range: 21-990 ng/dL). Preoperative serum elastase 1 levels were significantly higher in those with tumors ≥ 20 mm in diameter (vs. < 20 mm, P = 0.018), WHO grade 2 (vs. grade 1, P = 0.035), and microscopic venous invasion (vs. without venous invasion, P = 0.039). The median preoperative serum level of elastase 1 was higher in patients with recurrence than in those without recurrence (251 vs. 80 ng/dL, P = 0.004). Receiver operating characteristic analysis of elastase 1 levels showed that a cutoff level of 250 ng/dL was associated with postoperative recurrence, with 63% sensitivity, 100% specificity, and 94% overall accuracy. Patients with higher elastase 1 levels showed significantly worse recurrence-free survival than that of those with lower levels (2-year recurrence-free survival rate: 25% and 92%, respectively, P < 0.001). CONCLUSIONS: Our data provide the first evidence that high preoperative elastase 1 levels may be a risk factor for postoperative recurrence in patients with resectable PanNETs.Oct. 2018, Ann Surg Oncol, 25(11) (11), 3358 - 3364, English, International magazine[Refereed]Scientific journal
- (株)東京医学社, Oct. 2018, 消化器内視鏡, 30(増刊) (増刊), 192 - 193, Japanese【胆膵疾患内視鏡アトラス】 胆嚢 ポリープ 2cmくらいまで 転移性腫瘍[Invited]
- Aug. 2018, Histopathology, 73(2) (2), 259 - 272, EnglishInterleukin-33 overexpression reflects less aggressive tumour features in large-duct type cholangiocarcinomas[Refereed]Scientific journal
- (一社)日本消化器外科学会, Jul. 2018, 日本消化器外科学会総会, 73回, 806 - 806, Japanese腹部悪性腫瘍に対する粒子線治療適応拡大を可能とする新規素材吸収性スペーサーの開発と臨床応用
- (株)メディカ出版, Jul. 2018, 消化器外科Nursing, 23(7) (7), 604 - 609, Japanese[Refereed]
- Elsevier {BV}, Jun. 2018, Pancreatology, 18(4) (4), 399 - 406, English[Refereed]Scientific journal
- (一社)日本移植学会, May 2018, 移植, 53(1) (1), 71 - 77, Japanese[Refereed]
- 日本胆道学会, May 2018, 胆道, 32(2) (2), 307 - 311, Japanese[Refereed]
- (一社)日本外科学会, Apr. 2018, 日本外科学会定期学術集会抄録集, 118回, 1019 - 1019, Japanese粒子線治療適応拡大を可能とするスペーサー手術の現状と展望
- BACKGROUND: The prognostic impact of pancreatic ductal adenocarcinoma (PDAC) invasion to the splenic vessel is controversial. OBJECTIVE: The aim of this study was to assess the clinical value of pathological and radiological splenic vessel invasion in PDACs of the body and tail. METHODS: Medical records of patients with resectable PDAC of the body and tail who underwent distal pancreatectomy between 2003 and 2016 at the Kobe University Hospital were retrospectively analyzed. RESULTS: Overall, 68 patients (29 female and 39 male patients) were enrolled. Pathologically determined splenic vein invasion (p-SV) and splenic artery invasion (p-SA) were identified in 21 (30.9%) and 5 (7.4%) patients, respectively. The p-SV (but not p-SA) was an independent prognostic factor in multivariate analysis (p = 0.009). On analysis of recurrence patterns, patients with PDAC positive for p-SV were at a higher risk for liver metastasis (p = 0.022); however, the associations were not significant for other recurrence patterns. Liver metastasis occurred earlier in patients who were positive for p-SV (p = 0.015). Preoperative computed tomography effectively diagnosed pathological vessel invasion (SV: sensitivity, 95.2%, specificity, 72.3%; SA: sensitivity, 100%, specificity, 84.1%). Radiological SV invasion remained significant in multivariate analysis regarding postoperative survival (p = 0.007), and was also associated with early liver metastases (p = 0.008). CONCLUSIONS: Pathological/radiological SV invasion were independent adverse prognostic factors associated with early liver metastasis in patients with PDAC of the body/tail. Assessment of these findings may be useful in determining optimal therapeutic options in these patients.Mar. 2018, Ann Surg Oncol, 25(3) (3), 638 - 646, English, International magazine[Refereed]Scientific journal
- 金原出版(株), Mar. 2018, 手術, 72(3) (3), 315 - 319, Japanese[Refereed][Invited]
- 医学図書出版(株), Mar. 2018, 胆と膵, 39(3) (3), 283 - 286, Japanese[Refereed][Invited]
- Feb. 2018, Infect Agent Cancer, 13, 7, EnglishQuasispecies variant of pre-S/S gene in HBV-related hepatocellular carcinoma with HBs antigen positive and occult infection[Refereed]Scientific journal
- Feb. 2018, Can J Surg, 61(1) (1), E1, English, International magazineIntraoperative ultrasonic cholangiography for biliary system identification[Refereed]Scientific journal
- Elsevier {BV}, Jan. 2018, Pancreatology, 18(1) (1), 54 - 60, English[Refereed]Scientific journal
- PURPOSE: The safety and efficacy of reinforced staplers during distal pancreatectomy (DP) remain controversial because of the small sample size. This multicenter single-arm prospective study aims to evaluate the safety and efficacy of reinforced staplers with bioabsorbable material during DP. METHODS: Between October 2014 and August 2015, 121 patients scheduled for DP were enrolled in this study at 11 institutions in Japan. The primary endpoint was the incidence of clinically relevant pancreatic fistula. Protocol treatment was defined as "distal pancreatectomy using reinforced staplers." RESULTS: Per-protocol analysis of 105 patients was performed; 16 of the patients were excluded based on discontinuation of protocol treatment criteria. Clinically relevant pancreatic fistula occurred in 13 (12.4%) of 105 patients. The overall morbidity rate was 29.5% (31 of 105 patients) and severe complication (Clavien classification IIIa or more) was 10.5% (11/105). Mortality rate was 0%, although reoperations were performed on two patients (1.9%). Multivariate logistic regression analysis of independent risk factors for clinically relevant pancreatic fistula after DP using reinforced stapler closure was operative time more than 240 min (P = 0.047, odds ratio 5.79), registration numbers less than 10 (P = 0.046, odds ratio 13.01), and staple line hemorrhage (P = 0.003, odds ratio 16.34). CONCLUSION: This study confirms the safety of reinforced staplers for pancreatic stump closure during DP. However, the efficacy of reinforced staplers for decreasing clinically relevant pancreatic fistula could not be drawn from this study. TRIAL REGISTRATION: This prospective study was registered with ClinicalTrials.gov (NCT02270554) and UMIN Clinical Trial Registry (UMIN000015384).Dec. 2017, Langenbeck's archives of surgery, 402(8) (8), 1197 - 1204, English, International magazine[Refereed]Scientific journal
- Dec. 2017, SURGERY, 162(6) (6), 1241 - 1249, English[Refereed]Scientific journal
- BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) often infiltrates to the adjacent major vasculatures; however, direct invasion of PDAC to the inferior vena cava (IVC) is uncommon. CASE PRESENTATION: We report our experience with three cases of PDAC directly invading the IVC wall. All three patients underwent pancreatoduodenectomy along with wedge resection of the IVC wall without severe postoperative complications. Histopathological studies revealed tumor infiltration to the adventitia of the IVC. All patients achieved negative surgical margins. One patient was still alive 26 months after surgery without tumor recurrence. Two patients experienced recurrence; one patient experienced liver metastasis but was still alive and in a stable condition without further tumor progression 12 months after surgery. Another patient experienced multiple liver metastasis 10 months after surgery and died 26 months after surgery. CONCLUSIONS: Pancreatoduodenectomy along with wedge resection of the IVC wall for patients with PDAC directly invading the adventitia of the IVC can be performed safely. Further accumulation of cases is needed to elucidate the prognostic impact of IVC invasion.Dec. 2017, Surg Case Rep, 3(1) (1), 72 - 72, English, International magazine[Refereed]Scientific journal
- (株)癌と化学療法社, Nov. 2017, 癌と化学療法, 44(12) (12), 1976 - 1978, Japanese
- (株)癌と化学療法社, Nov. 2017, 癌と化学療法, 44(12) (12), 1717 - 1719, Japanese
- Nov. 2017, WORLD JOURNAL OF SURGERY, 41(11) (11), 2867 - 2875, English[Refereed]Scientific journal
- Nov. 2017, PANCREATOLOGY, 17(6) (6), 956 - 961, English[Refereed]Scientific journal
- (一社)日本消化器内視鏡学会, Sep. 2017, Gastroenterological Endoscopy, 59(Suppl.2) (Suppl.2), 1917 - 1917, Japanese非B非C肝細胞癌に対する外科切除例の検討
- Jul. 2017, PANCREAS, 46(6) (6), 835 - 835, EnglishA Case of Pancreatic Neuroendocrine Tumor Mimicking Branch Duct IPMN
- (一社)日本消化器外科学会, Jul. 2017, 日本消化器外科学会総会, 72回, O2 - 4, Japanese臨床応用を目指した消化器外科領域の基礎研究・橋渡し研究6 腹部悪性腫瘍に対する粒子線治療適応拡大を可能とする新規素材吸収性スペーサーの開発と臨床応用
- BACKGROUND: It remains controversial whether preoperative cholangitis affects long-term outcomes after resection in patients with extrahepatic bile duct cancer. METHODS: A total of 107 patients with extrahepatic bile duct cancer who underwent resection with curative intent from 2008 to 2014 were retrospectively reviewed. Patients were categorized into two groups according to the presence or absence of preoperative cholangitis. Clinicopathological variables and long-term outcomes were compared in the two groups. RESULTS: In the preoperative cholangitis group, the rate of preoperative biliary drainage, the number of tube changes and/or additions, and the rate of lymph node metastasis were higher compared to the no-cholangitis group. Overall survival and disease-free survival were significantly worse in the cholangitis group compared to the no-cholangitis group (p = 0.022, p = 0.007). A poorer prognosis was not observed with an increasing grade of cholangitis in Tokyo Guidelines 2013 (p = 0.09). A multivariate logistic regression analysis revealed that the preoperative cholangitis was an independent prognostic factor for extrahepatic bile duct cancer. CONCLUSION: Preoperative cholangitis is an independent prognostic factor in patients with extrahepatic bile duct cancer regardless of the severity of the cholangitis.Jun. 2017, Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 21(6) (6), 983 - 989, English, International magazineScientific journal
- BACKGROUND: Elevations in blood lactate levels have been associated with poor postoperative outcome. The aim of the present study was to determine if preoperative supplementation with branched-chain amino acids (BCAA) decreases postoperative blood lactate levels in patients undergoing pancreatoduodenectomy. METHODS: The cases of 223 consecutive patients who underwent pancreatoduodenectomy were retrospectively reviewed. Postoperative blood lactate levels in patients who were treated with BCAA supplementation before pancreatoduodenectomy (December 2011-December 2014) were compared with levels in patients who were not pretreated (January 2008-November 2011). RESULTS: Postoperative lactate levels were significantly lower in patients who received preoperative BCAA supplementation than in patients who did not (2.6 vs 3.1 mmol/L, P = .005), although preoperative blood lactate levels were statistically equivalent between the groups. In the univariate analysis, preoperative BCAA supplementation, preoperative lactate levels, operation time, and postoperative glucose levels were associated with postoperative lactate levels. A multiple regression analysis was performed among the 4 factors, and the preoperative use of BCAA supplementation was independently correlated with postoperative lactate levels ( P = .046). CONCLUSIONS: Preoperative BCAA supplementation decreased postoperative blood lactate levels. These results suggest that preoperative BCAA supplementation may help patients recover after surgery.Jun. 2017, JPEN J Parenter Enteral Nutr, 148607117718494 - 148607117718494, English, International magazine[Refereed]Scientific journal
- Jun. 2017, SURGERY, 161(6) (6), 1553 - 1560, English[Refereed]Scientific journal
- Apr. 2017, ANNALS OF SURGICAL ONCOLOGY, 24(4) (4), 1127 - 1133, English[Refereed]Scientific journal
- The present study aimed to elucidate whether the stemness molecule, CD133, is expressed in well-differentiated pancreatic neuroendocrine tumors (PanNETs; World Health Organization grades 1 and 2) and establish its clinical relevance using 2 separate cohorts. In the first series (n = 178) in which tissue microarrays were available, immunohistochemistry revealed that CD133 was expressed in 14 cases (8%). CD133+ PanNETs had higher TNM stages (P < .01), more frequent lymphovascular invasion (P = .01), and higher recurrence rates (P = .01). In the second cohort (n = 56), the expression of CD133 and CK19 was examined in whole tissue sections. CD133 and CK19 were positive in 10 (18%) and 36 (64%) cases, respectively. CD133 expression correlated with higher pT scores (P < .01), the presence of microscopic venous infiltration (P = .03), and shorter disease-free periods (P < .01). When cases were divided into grade 1 and 2 neoplasms, patients with CD133+ PanNET continued to have shorter disease-free periods than did those with CD133- tumors in both groups (P < .01 and P = .02, respectively). Although CK19+ cases had shorter disease-free periods than did CK19- cases in the whole cohort (P = .02), this difference was less apparent in subanalyses of grade 1 and 2 cases. CD133 expression also appeared to be an independent predictive factor for tumor recurrence in a multivariate analysis (P = .018). The CD133 phenotype was identical between primary and metastatic foci in 17 of 18 cases from which tissues of metastatic deposits were available. In conclusion, the combination of CD133 phenotyping and World Health Organization grading may assist in stratifying patients in terms of the risk of progressive clinical courses.Mar. 2017, Human pathology, 61, 148 - 157, English, International magazineScientific journal
- Elsevier {BV}, Jan. 2017, Pancreatology, 17(1) (1), 123 - 129Scientific journal
- 2017, DIGESTIVE SURGERY, 34(2) (2), 114 - 124, English[Refereed]Scientific journal
- 2017, Oncology, 93(Suppl 1) (Suppl 1), 61 - 68, English[Refereed]Scientific journal
- 2017, Pancreas, 46(4) (4), 582 - 588, English[Refereed]Scientific journal
- Nov. 2016, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 31, 410 - 410, EnglishImpact for prognosis after non-anatomical resection for hepatocellular carcinoma historically proven micro portal vein tumor thrombus
- (株)癌と化学療法社, Nov. 2016, 癌と化学療法, 43(12) (12), 1988 - 1990, Japanese[Refereed]
- (株)南江堂, Nov. 2016, 外科, 78(11) (11), 1157 - 1163, Japanese[Refereed]
- (株)癌と化学療法社, Nov. 2016, 癌と化学療法, 43(12) (12), 2193 - 2195, Japanese[Refereed]
- The Japanese Society of Gastroenterological Surgery, Nov. 2016, The Japanese Journal of Gastroenterological Surgery, 49(11) (11), 1108 - 1116, Japanese[Refereed]
- Oct. 2016, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 22(10) (10), 1437 - 42, English, International magazine[Refereed]Scientific journal
- Sep. 2016, PANCREATOLOGY, 16(5) (5), 882 - 887, English[Refereed]Scientific journal
- This study aimed to evaluate the efficacy of stereotactic body radiotherapy (SBRT) compared with three-dimensional conformal radiotherapy (3DCRT). Forty-three patients with portal vein tumor thrombosis (PVTT)/inferior vena cava tumor thrombosis (IVCTT) treated with SBRT (27 with CyberKnife (CK) and 16 with TrueBeam (TB)) from April 2013 to December 2014, and 54 treated with 3DCRT from June 2008 to March 2013 were evaluated. Dosimetric parameters, response to radiotherapy (RT) and survival outcomes were compared in total SBRT vs. 3DCRT, CK vs. 3DCRT and TB vs. 3DCRT, respectively. The median biologically effective dose 10 (BED10) values in total SBRT, CK, TB and 3DCRT were 73.4 Gy10, 75.0 Gy10, 60.5 Gy10 and 58.5 Gy10, respectively (P < 0.001 in total SBRT vs. 3DCRT, P < 0.001 in CK vs. 3DCRT, P = 0.004 in TB vs. 3DCRT). The tumor response rates were 67%, 70%, 62% and 46%, respectively (P = 0.04, P = 0.04, P = 0.25). The 1-year overall survival rates were 49.3%, 56.7%, 38.1% and 29.3%, respectively (P = 0.02, P = 0.02, P = 0.30), and the 1-year local progression rates were 20.4%, 21.9%, 18.8% and 43.6%, respectively (P = 0.01, P = 0.04, P = 0.10). The use of SBRT made it possible to achieve a higher BED10 compared with the use of 3DCRT. Improvements in local control and survival were achieved in the CK group and the total SBRT group. Our results suggest that SBRT may have the potential to be the standard RT technique for the treatment of PVTT/IVCTT.Sep. 2016, Journal of radiation research, 57(5) (5), 512 - 523, English, International magazine[Refereed]Scientific journal
- Elsevier {BV}, Sep. 2016, Pancreatology, 16(5) (5), 893 - 899Scientific journal
- 日本臨床外科学会, Aug. 2016, 日本臨床外科学会雑誌, 77(8) (8), 2063 - 2068, Japanese[Refereed]
- (一社)日本膵臓学会, Aug. 2016, 膵臓, 31(4) (4), 670 - 678, Japanese[Refereed]
- Jul. 2016, Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 16(4) (4), 615 - 620[Refereed]
- A Case Report of Drug-Induced Thrombocytopenia after Living Donor Liver Transplantation.There are few descriptions of severe thrombocytopenia during the early postoperative period after liver transplantation, and these have not been fully documented in the literature. Here, we report a case of drug-induced thrombocytopenia requiring transfusion of blood products after living donor liver transplantation. We determined that this was not caused by the interferon-free anti-viral therapy but by tacrolimus A 61-year-old woman with hepatitis C-related cirrhosis and hepatorenal syndrome underwent living donor liver transplantation using a left lobe graft from her son. After transplantation, immunosuppression consisted of tacrolimus and steroid. Seven weeks after transplantation, interferon-free therapy with daclatasvir and asunaprevir was started. Thirteen days thereafter, hepatitis C virus tested negative. However, the platelet count had begun to gradually decrease just before starting anti-viral therapy. Daclatasvir and asunaprevir were stopped because this was suspected to be a side-effect of these drugs, but the patient nonetheless went on to develop severe thrombocytopenia (platelet count 17,000/μL), which needed transfusions. Now suspecting tacrolimus as the inducer of this side effect, we changed to cyclosporin, after which the platelet count gradually recovered. Viral markers were still not detectable up to 2 months after discontinuation of the antiviral drugs. We conclude that when severe thrombocytopenia occurs, possible drug-induced thrombocytopenia as well as other disorders must be investigated.Jun. 2016, The Kobe journal of medical sciences, 62(1) (1), E9-E12, English, Domestic magazineScientific journal
- May 2016, TRANSPLANTATION, 100, S255 - S255, EnglishRole of Contrast-Enhanced Intraoperative Ultrasonic Cholangiography in Living Donor Hepatectomy
- May 2016, Journal of the American College of Surgeons, 222(5) (5), e31 - 8, English, International magazine[Refereed]Scientific journal
- May 2016, Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 16(3) (3), 454 - 463[Refereed]
- Apr. 2016, GASTROENTEROLOGY, 150(4) (4), S1215 - S1215, EnglishClinical Usefulness of Staging Laparoscopy in Patients With Biliary Tract Cancer Following Criteria Based on Inflammation-Based Prognostic Scores and Tumor Markers
- Apr. 2016, GASTROENTEROLOGY, 150(4) (4), S1236 - S1236, EnglishPrognostic Factors After Surgical Resection for Patients With Biliary Tract Cancer
- The Predictive Power of Serum α-Fetoprotein and Des-γ-Carboxy Prothrombin for Survival Varies by Tumor Size in Hepatocellular Carcinoma.Alpha-fetoprotein (AFP) and des-γ-carboxy prothrombin (DCP) are frequently used as tumor markers in hepatocellular carcinoma (HCC). The authors hypothesized different patient populations with varying tumor sizes would influence the predictive power of tumor markers for survival in HCC patients. The authors investigated the influence of tumor size on predictive powers of AFP and DCP. 181 patients underwent hepatectomy for HCC from 2003 to 2008 at Kobe University Hospital. Tumor markers were measured before and at 1 month post-hepatectomy. The Cox proportional-hazards model revealed that preoperative serum AFP was associated with survival; its effects depended on tumor size. Hazard ratios (HRs) for preoperative AFP were maximum for medium-sized HCC, and for DCP, HRs were maximum in small-sized tumors. Post-hepatectomy, both tumor markers were associated with survival, revealing significant interactions with tumor size. HRs for postoperative AFP were greater than 1 for relatively wide range tumors (3-11 cm). HRs for postoperative DCP increased with tumor size, with a strong prognostic predictive power for tumors >5 cm. The predictive power of serum tumor markers varied by tumor size in HCC patients. By selecting the appropriate tumor marker, its predictive power can be improved.Mar. 2016, The Kobe journal of medical sciences, 61(5) (5), E124 - 31, English, Domestic magazine[Refereed]Scientific journal
- PURPOSE: Pancreaticobiliary maljunction (PBM) arises from a developmental abnormality during the embryonic period; thus, these patients may have anatomical variations of the liver blood supply, including aberrant vessels and unusual locations. METHODS: We reviewed retrospectively the vascular anatomy of 52 patients with PBM, who were seen between 1998 and 2013. RESULTS: There were 11 male patients and 41 female patients. Sixteen patients had bile duct type (C-P type) PBM, 35 had pancreatic duct type (P-C type) PBM, and one had complex type PBM. Thirty-three patients had biliary dilatation. Nine (17.3 %) patients had an aberrant (replaced or accessory) hepatic artery and 2 (3.8 %) had an aberrant portal vein. Among 39 patients evaluated by contrast-enhanced computed tomography, 8 (20.5 %) had their right hepatic artery positioned on the ventral side of the common bile duct. The presence of aberrant hepatic vessels was not related to the type of confluence, biliary dilatation, type of Todani classification, or associated biliary malignancies. CONCLUSIONS: The incidence of the right hepatic artery being located on the ventral side of the common bile duct may be higher in patients with PBM than the naturally occurring incidence of about 10 % in the general Japanese population.Feb. 2016, Surgery today, 46(2) (2), 169 - 175, English, Domestic magazine[Refereed]Scientific journal
- (株)アークメディア, Jan. 2016, 肝・胆・膵, 72(1) (1), 121 - 125, Japanese[Refereed]
- UNLABELLED: To develop a biodegradable clip, the equivalent plastic strain distribution during occlusion was evaluated by the finite element analysis (FEA) using the material data of pure Mg. Since the FEA suggested that a maximum plastic strain of 0.40 is required to allow the Mg clips, the alloying of magnesium with essential elements and the control of microstructure by hot extrusion and annealing were conducted. Mechanical characterization revealed that the Mg-Zn-Ca alloy obtained by double extrusion followed by annealing at 673K for 2h possessed a fracture strain over 0.40. The biocompatibility of the alloy was confirmed here by investigating its degradation behavior and the response of extraperitoneal tissue around the Mg-Zn-Ca alloy. Small gas cavity due to degradation was observed following implantation of the developed Mg-Zn-Ca clip by in vivo micro-CT. Histological analysis, minimal observed inflammation, and an only small decrease in the volume of the implanted Mg-Zn-Ca clip confirmed its excellent biocompatibility. FEA using the material data for ductile Mg-Zn-Ca also showed that the clip could occlude the simulated vessel without fracture. In addition, the Mg-Zn-Ca alloy clip successfully occluded the renal vein. Microstructural observations using electron backscattering diffraction confirmed that dynamic recovery occurred during the later stage of plastic deformation of the ductile Mg-Zn-Ca alloy. These results suggest that the developed Mg-Zn-Ca alloy is a suitable material for biodegradable clips. STATEMENT OF SIGNIFICANCE: Since conventional magnesium alloys have not exhibited significant ductility for applying the occlusion of vessels, the alloying of magnesium with essential elements and the control of microstructure by hot extrusion and annealing were conducted. Mechanical characterization revealed that the Mg-Zn-Ca alloy obtained by double extrusion followed by annealing at 673K for 2h possessed a fracture strain over 0.40. The biocompatibility of the alloy was confirmed by investigating its degradation behavior and the response of extraperitoneal tissue around the Mg-Zn-Ca alloy. Finite element analysis using the material data for the ductile Mg-Zn-Ca alloy also showed that the clip could occlude the simulated vessel without fracture. In addition, the Mg-Zn-Ca alloy clip successfully occluded the renal vein. Microstructural observations using electron backscattering diffraction confirmed that dynamic recovery occurred during the later stage of plastic deformation of the ductile Mg-Zn-Ca alloy.Jan. 2016, Acta Biomaterialia, 29, 468 - 476, English, International magazine[Refereed]Scientific journal
- Acute graft-versus-host-disease (aGVHD) is a rare complication in the setting of pancreas-kidney transplantation (PKT). We herein describe the case of a 37-year-old male with severe type 1 diabetes with chronic renal failure who received simultaneous PKT from a female donor. Diarrhea developed on postoperative day (POD) 10. Subsequently, fever and liver dysfunction occurred on POD 32. Skin rashes appeared with pain and itching on his trunk and extremities on POD 40. As pancytopenia occurred on POD 63, bone marrow biopsies demonstrated profound hypoplastic marrow. On POD 69, we eventually made a definitive diagnosis of aGVHD because skin biopsies revealed the XX chromosome signal in a fluorescence in situ hybridization analysis. Thereafter, 100 mg of prednisolone was administered for 5 days. Although every symptom was temporarily improved, on POD 156, the patient expired from the septic pneumonia without any effects of antibiotics. Clinician should be aware that PKT has the potential to induce aGVHD.Dec. 2015, Surgery today, 45(12) (12), 1567 - 1571, English, Domestic magazine[Refereed]Scientific journal
- Nov. 2015, TRANSPLANT INTERNATIONAL, 28, 138 - 138, EnglishINCIDENCE OF POSTHEPATECTOMY LIVER FAILURE AS DEFINED BY ISGLS AMONG LIVING LIVER DONORS
- 金原出版(株), Nov. 2015, 手術, 69(12) (12), 1721 - 1726, Japanese[Refereed]
- (一社)日本肝臓学会, Nov. 2015, 肝臓, 56(11) (11), 555 - 566, Japanese[Refereed]
- (株)癌と化学療法社, Nov. 2015, 癌と化学療法, 42(12) (12), 1500 - 1502, Japanese[Refereed]
- (株)癌と化学療法社, Nov. 2015, 癌と化学療法, 42(12) (12), 2391 - 2393, Japanese
- Nov. 2015, Gan to kagaku ryoho. Cancer & chemotherapy, 42(12) (12), 2391 - 2393[A Case of Invasive Intraductal Papillary Mucinous Carcinoma, Penetrating the Stomach, Colon, and Jejunum].[Refereed]
- (株)癌と化学療法社, Sep. 2015, 癌と化学療法, 42(9) (9), 1111 - 1114, Japanese
- Sep. 2015, Gan to kagaku ryoho. Cancer & chemotherapy, 42(9) (9), 1111 - 1114[Successful Multimodal Treatment for Aggressive Extrahepatic Metastatic Hepatocellular Carcinoma - A Case Report].[Refereed]
- (株)医学書院, Jul. 2015, 臨床外科, 70(7) (7), 838 - 843, Japanese[Refereed]
- BACKGROUND: Adjuvant chemotherapy (AC) is recommended as a standard treatment after curative resection in patients with pancreatic adenocarcinoma (PA). Although patients who failed to complete AC had significantly worse survival compared with those who completed AC for cancers in various organs, the effects of complete AC on survival in patients with PA have not been investigated. The purpose of this study was to clarify the impact of complete AC on PA patient survival and to identify independent risk factors for incomplete AC. METHODS: Medical records of 236 consecutive PA patients who planned to undergo surgical resection with curative intent between January 2000 and September 2012 at Kobe University Hospital were retrospectively reviewed. Of these, the complete AC (n = 75) and the incomplete AC (n = 30) groups due to adverse events were compared. RESULTS: Patient survival was significantly better in the complete AC group than in the incomplete AC group (median survival time 48.9 vs. 17.9 months; 5-year survival rate 42.7 vs. 17.1 %; p < 0.0001). Preoperative white blood cell count and postoperative serum albumin level were identified as independent risk factors for incomplete AC. By receiver operating characteristic curve analysis, the cutoff value of postoperative serum albumin level was 3.1 mg/dL. CONCLUSIONS: PA patients who completed AC had significantly better survival than those who failed to complete AC. Postoperative serum albumin level is a marker for failure to complete AC. Further prospective studies are needed to determine whether perioperative nutritional intervention could increase AC completion rate and improve prognosis in PA patients.Jul. 2015, Annals of surgical oncology, 22(7) (7), 2408 - 2415, English, International magazine[Refereed]Scientific journal
- May 2015, Transpl Int, English[Refereed]Scientific journal
- 金原出版(株), Apr. 2015, 手術, 69(5) (5), 753 - 759, Japanese[Refereed]
- (一社)日本外科学会, Apr. 2015, 日本外科学会定期学術集会抄録集, 115回(5) (5), IS - 8, English[Refereed]
- Post-transplant lymphoproliferative disorder (PTLD) is a well-known complication after transplantation. A living donor liver transplantation was performed on a 31-year-old man for fulminant hepatitis. He again developed liver dysfunction after 7 months. He was diagnosed as having acute cellular rejection and the steroid pulse therapy introduced resulted in little improvement. He gradually developed a high fever and right axillary lymphadenopathy appeared. Chest computed tomography (CT) was performed revealing small lung nodules and axillary lymphadenopathy. Because his serological status for Epstein-Barr virus was positive, PTLD was highly suspected and immunosuppression treatment was withdrawn with little improvement. One week later, he developed tachycardia. Chest CT was re-performed revealing an infiltration to the left cardiac chamber. For diagnosis, axillary lymph node biopsy was performed and during the procedure, he developed ventricular tachycardia (VT). Immunohistological staining revealed PTLD of T lymphocytes, and chemotherapy was introduced on the same day he developed VT. After two cycles of tetrahydropyranyl, adriamycin, cyclophosphamide, vincristine, prednisolone and etoposide treatment, he completely recovered. This is a first case report of severe PTLD with VT, and our case implies the feasibility of chemotherapy after the appearance of dissemination symptoms.Mar. 2015, Hepatol Res, 45(3) (3), 356 - 62, English, International magazine[Refereed]Scientific journal
- Mar. 2015, Asian J Endosc Surg, English[Refereed]Scientific journal
- PURPOSE: We rarely have an opportunity to perform pancreatoduodenectomy (PD) following the onset of severe acute pancreatitis (SAP) for patients with periampullary cancer. The perioperative risks and optimal timing of subsequent PD have, therefore, remained unclear. METHODS: Between January 2006 and December 2012, we performed PD in six patients with SAP. We reviewed these six cases, and compared the perioperative risks of morbidity and mortality with those of 81 concurrent PD patients matched for primary cancer without preoperative SAP. RESULTS: The six patients were classified as having SAP based on the Japanese criteria developed in 2008. The SAP in five patients was caused by ERCP procedures. The median interval from SAP onset to the operation was 111 days. The rate of Grade B/C postoperative pancreatic fistula formation in the SAP patients was significantly higher than that of the 81 control patients (83 vs. 26 %, P < 0.001). In addition, the median postoperative hospital stay was significantly longer in the six SAP patients relative to that of the control patients (40 vs. 30 days, P < 0.001). CONCLUSIONS: An interval of at least 3 months after surgery may be needed to decrease the inflammation of the peripancreas region after SAP. Therefore, unnecessary and low-yield ERCP procedures should be avoided in these patients.Feb. 2015, Surgery today, 45(2) (2), 181 - 188, English, Domestic magazine[Refereed]Scientific journal
- OBJECTIVE: The objective of the present study was to reappraise the clinical value of peritoneal washing cytology (CY) in 984 pancreatic ductal adenocarcinoma patients who underwent margin-negative resection. METHODS: In a 2001-2011 database from seven high-volume surgical institutions in Japan, 69 patients (7%) had positive CY (CY+ group) indicative of M1 disease and 915 patients had negative CY (CY- group). Clinicopathological data and survival were compared between groups. RESULTS: Significant correlations between CY+ and high CA19-9 level, pancreatic body and tail cancer, lymph node metastasis, and a lower frequency of R0 resection were observed. Overall survival (OS) of CY+ patients was significantly worse than that of CY- patients (median survival time [MST], 16 vs. 25 months; 3-year OS rate, 6 vs. 37%; p < 0.001). CY+ patients had a significantly higher rate of post-operative peritoneal carcinomatosis than CY- patients (48 vs. 21%; p < 0.001). Administration of adjuvant chemotherapy did not provide a favorable survival outcome to CY+ patients. The current study showed that patients with M1 disease had acceptable MST after margin-negative resection and a high incidence of peritoneal carcinomatosis within 3 years after surgery, resulting in decreased long-term survival. The development of a new strategy to control peritoneal carcinomatosis when surgical resection is performed in such patients is required.Jan. 2015, Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 19(1) (1), 6 - 14, English, International magazineScientific journal
- (株)日本臨床社, Jan. 2015, 日本臨床, 73(増刊1 最新肝癌学) (増刊1 最新肝癌学), 693 - 698, Japanese[Refereed]
- (株)へるす出版, Jan. 2015, 消化器外科, 38(1) (1), 45 - 55, Japanese【膵悪性腫瘍に対する手術;エビデンス、術式と適応、手術手技のエッセンス】重症急性膵炎合併・随伴性膵炎既往症例に対する膵頭十二指腸切除術
- BACKGROUND: Although preoperative biliary drainage in jaundiced patients is controversial, external biliary drainage (EBD) is beneficial for infection control in patients with biliary cancers. When EBD is performed, additional bile replacement (BR) has the benefit of improving impaired intestinal barrier function, but the detailed mechanism remains unknown. We examined the effect of bile replacement on immune functions over the duration of BR in jaundiced patients. METHODS: Fifteen patients were enrolled into this prospective study. BR was started soon after the total serum bilirubin concentration reached 5.0 mg/dl and was continued for 14 days. Drained bile was given two times orally (2 × 100 ml/day). Concanavalin A (Con A)- and phytohemagglutinin (PHA)-stimulated lymphocyte proliferation and serum diamine oxidase (DAO) activity were measured before starting and during BR. Twenty patients with EBD and no BR were analyzed as a control group. RESULTS: Serum liver enzymes, prothrombin time-international normalized ratio (PT-INR), and responses to Con A and PHA gradually improved over the 14 days of BR, but percentages of lymphocytes and DAO levels did not. PT-INR, and Con A and PHA responses did not improve during EBD in the control group. PT-INR significantly decreased in patients with a greater fraction of their drained bile replaced. CONCLUSIONS: Our results indicate that preoperative BR using as large a quantity of bile as possible is useful for improving blood coagulability and cellular immunity in patients with EBD.Dec. 2014, Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 18(12) (12), 2095 - 2104, English, International magazine[Refereed]Scientific journal
- (一社)日本消化器外科学会, Dec. 2014, 日本消化器外科学会雑誌, 47(12) (12), 776 - 782, Japanese
- Nov. 2014, Gan to kagaku ryoho. Cancer & chemotherapy, 41(12) (12), 2178 - 2180[A case of adjuvant surgery for a patient with initially unresectable locally advanced pancreatic cancer (LAPC) with a favorable response to S-1 chemotherapy].[Refereed]
- (株)癌と化学療法社, Nov. 2014, 癌と化学療法, 41(12) (12), 2178 - 2180, Japanese
- (株)癌と化学療法社, Nov. 2014, 癌と化学療法, 41(12) (12), 1468 - 1470, Japanese
- (株)癌と化学療法社, Nov. 2014, 癌と化学療法, 41(12) (12), 1542 - 1544, Japanese
- (株)癌と化学療法社, Nov. 2014, 癌と化学療法, 41(12) (12), 2071 - 2073, Japanese
- (株)癌と化学療法社, Nov. 2014, 癌と化学療法, 41(12) (12), 2107 - 2109, Japanese
- (株)癌と化学療法社, Nov. 2014, 癌と化学療法, 41(12) (12), 2214 - 2216, Japanese
- Nov. 2014, Gan to kagaku ryoho. Cancer & chemotherapy, 41(12) (12), 1468 - 1470[Re-resection for recurrent intrahepatic cholangiocarcinoma].[Refereed]
- Nov. 2014, Gan to kagaku ryoho. Cancer & chemotherapy, 41(12) (12), 1542 - 1544[Long-term survivor of unresectable bile duct cancer complicated with sclerosing cholangitis treated with chemotherapy].[Refereed]
- Nov. 2014, Gan to kagaku ryoho. Cancer & chemotherapy, 41(12) (12), 2071 - 2073[A case of resection of a metastatic liver tumor that recurred after particle beam therapy].[Refereed]
- Nov. 2014, Gan to kagaku ryoho. Cancer & chemotherapy, 41(12) (12), 2107 - 2109[Long-term survival in a patient receiving multidisciplinary therapy for hepatocellular carcinoma with left iliac bone metastasis].[Refereed]
- Nov. 2014, Gan to kagaku ryoho. Cancer & chemotherapy, 41(12) (12), 2214 - 2216[Hassab's operation for left-sided portal hypertension after pancreatoduodenectomy].[Refereed]
- PURPOSE: This study aimed at assessing the prognostic factors of resection of intrahepatic cholangiocarcinoma (IHCC), which remain unclear. METHODS: Among 70 patients with IHCC, who were admitted to our hospital between 1998 and 2011, 45 (64 %) underwent resection and 25 had unresectable tumors. Univariate and multivariate analyses were conducted retrospectively to assess the factors influencing survival of the patients who underwent resection. RESULTS: The median survival times of the patients who underwent resection versus those who did not were 16 months versus 9 months, respectively (P < 0.001). Multivariate analysis identified residual tumor status (relative risk 4.12, P = 0.04) and pathological differentiation (relative risk 5.55, P = 0.04) as independent factors predicting survival. Patients who underwent R1 resection had a significantly higher rate of local recurrence than those who underwent R0 resection (P = 0.008). With R0 resection, there were no significant differences in patterns and rates of recurrence between patients with narrow (≤ 5 mm) versus wide (>5 mm) surgical margins. CONCLUSIONS: R0/1 resection and a well-differentiated tumor were found to be independent prognostic factors for long-term survival after IHCC resection. If R0 resection was achieved, the width of the negative surgical margin did not affect the patterns and rates of recurrence.Oct. 2014, Surgery today, 44(10) (10), 1847 - 1854, English, Domestic magazine[Refereed]Scientific journal
- (株)南江堂, Aug. 2014, 外科, 76(8) (8), 882 - 886, Japanese[Refereed]
- Short- and long-term results of modified Frey's procedure in patients with chronic pancreatitis: a retrospective Japanese single-center study.BACKGROUND: The study aim was to determine the short- and long-term results of surgical drainage procedure for chronic pancreatitis at a single center in Japan. METHODS: The records of 28 consecutive patients were retrospectively reviewed. All patients underwent surgery at Kobe University Hospital between June 1999 and April 2013. Long-term follow-up was performed in all patients for a median period of 77 months. RESULTS: The 26 men (93%) and 2 women (7%) had a mean age of 47 years. The etiology of pancreatitis was chronic alcohol abuse in 24 patients (86%). The major indication for surgery was persistent symptoms (97%). Modified Frey's procedure in 21 patients, lateral pancreaticojejunostomy (LPJ) in 6 patients, LPJ and distal pancreatectomy in one patient, were performed. There was no postoperative mortality. Postoperative morbidity occurred in 6 patients (21%). The percentage of pain-free patients after surgery was 97%, and further acute exacerbation was prevented in 97%. Two patients (6%) required subsequent surgery for infectious pancreatic cyst and intraabdominal abscess. Of the patients that completed follow-up, 13 (46%) had diabetes mellitus, including 5 patients (19%) with new-onset diabetes, and 6 patients (19%) developed pancreatic exocrine insufficiency. CONCLUSIONS: Modified Frey's procedure is safe, feasible, and effective to manage chronic pancreatitis. The technique prevents further exacerbations and maintains appropriate pancreatic endocrine and exocrine function.Aug. 2014, The Kobe journal of medical sciences, 60(2) (2), E30 - 6, English, Domestic magazine[Refereed]Scientific journal
- Hepatic epithelioid hemangioendothelioma (HEH) is a rare neoplasm of vascular origin with variable malignant potential. Because most patients with this condition have multiple bilobar lesions, liver transplantation is the standard treatment, and hepatectomy is much less frequently indicated. We describe a case of a 35-year-old woman with unresectable multiple bilobar HEH successfully treated by combination treatment with hepatectomy and carbon-ion radiotherapy. This case is very meaningful since it demonstrated the effectiveness of carbon-ion radiotherapy for HEH and the possibility of expanding the curative treatment options for multiple bilobar hepatic tumors.Jul. 2014, World journal of gastroenterology, 20(26) (26), 8729 - 35, English, International magazineScientific journal
- (有)科学評論社, Jul. 2014, 消化器内科, 59(1) (1), 43 - 49, Japanese[Refereed]
- Jul. 2014, International Cancer Conference Journal, 3(3) (3), 173 - 177, EnglishRapid progression of second bile duct cancer after resection for extrahepatic bile duct cancer[Refereed]Scientific journal
- A 25-year-old woman was referred to our hospital with persistent upper abdominal pain. Preoperative imaging studies revealed a hilar bile duct stricture with portal venous encasement, and the patient underwent curative resection involving extended left hepatectomy and segmental portal vein resection. The pathological findings demonstrated a well-differentiated tubular adenocarcinoma of the bile duct with regional lymph node metastasis (stage IIIB according to the UICC TNM classification), as well as the overexpression of p53 proteins and the K-ras gene mutation in tumor cells. The patient has shown no evidence of recurrence in the 10 months since the operation. Although there are several reports of relatively young adults with cholangiocarcinoma, the majority of such patients demonstrate either an anomalous arrangement of the pancreaticobiliary duct system or primary sclerosing cholangitis. The absence of any morphological abnormalities in this patient's biliary system implicates de novo carcinogenesis as the most likely cause of the cholangiocarcinoma.Jul. 2014, Surgery today, 44(7) (7), 1350 - 1354, English, Domestic magazine[Refereed]Scientific journal
- (有)科学評論社, Jun. 2014, 消化器内科, 58(6) (6), 788 - 791, Japanese
- 金原出版(株), Jun. 2014, 手術, 68(7) (7), 919 - 922, Japanese
- BACKGROUND AND OBJECTIVES: Pylorus-preserving pancreatoduodenectomy (PPPD) has been associated with a high incidence of delayed gastric emptying (DGE). There are few studies comparing DGE associated with PPPD and subtotal stomach-preserving pancreatoduodenectomy (SSPPD). Moreover, differences between the procedures with respect to long-term results have not been reported. A prospective randomized study was conducted to compare perioperative complications and long-term nutritional status with PPPD and SSPPD. METHODS: One hundred patients with periampullary lesions were randomized to receive either PPPD (n = 50) or SSPPD (n = 50). All patients were followed up for 3 years after surgery or to the time of recurrence to evaluate nutritional status for the study. The effects of the procedure, age, and malignancy on changes in nutritional indicators were estimated with linear mixed models. This study was registered at UMIN Clinical Trials Registry (UMIN 000012337). RESULTS: The incidence of DGE assessed by the International Study Group of Pancreatic Surgery was 20% with PPPD and 12% with SSPPD (P = 0.414). There were no significant differences between the two procedures on postoperative serum albumin levels, serum total cholesterol levels, and body mass index during the 3-year follow-up period. CONCLUSIONS: SSPPD is equally effective in DGE occurrence rate and long-term nutritional status comparing to PPPD.Jun. 2014, Journal of surgical oncology, 109(7) (7), 690 - 696, English, International magazine[Refereed]Scientific journal
- (一社)日本膵臓学会, Apr. 2014, 膵臓, 29(2) (2), 247 - 252, Japanese[Refereed]
- Apr. 2014, JOURNAL OF GASTROINTESTINAL SURGERY, 18(4) (4), 729 - 736, English[Refereed]Scientific journal
- 医学図書出版(株), Mar. 2014, 胆と膵, 35(3) (3), 255 - 261, Japanese
- Mar. 2014, ANNALS OF SURGICAL ONCOLOGY, 21(3) (3), 971 - 978, English[Refereed]Scientific journal
- Feb. 2014, JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS, 218(2) (2), E43 - E50, English[Refereed]Scientific journal
- 日本胆道学会, Dec. 2013, 胆道, 27(5) (5), 811 - 816, Japanese[Refereed]
- 金原出版(株), Dec. 2013, 手術, 67(13) (13), 1825 - 1830, Japanese[Refereed][Invited]
- Nov. 2013, Gan to kagaku ryoho. Cancer & chemotherapy, 40(12) (12), 1681 - 1683[Analysis of the safety and efficacy of percutaneous isolated hepatic perfusion after particle therapy for advanced hepatocellular carcinoma].[Refereed]
- (株)癌と化学療法社, Nov. 2013, 癌と化学療法, 40(12) (12), 1681 - 1683, Japanese
- (株)癌と化学療法社, Nov. 2013, 癌と化学療法, 40(12) (12), 1741 - 1743, Japanese
- (株)癌と化学療法社, Nov. 2013, 癌と化学療法, 40(12) (12), 1744 - 1746, Japanese
- (株)癌と化学療法社, Nov. 2013, 癌と化学療法, 40(12) (12), 1822 - 1824, Japanese
- (株)癌と化学療法社, Nov. 2013, 癌と化学療法, 40(12) (12), 1893 - 1896, Japanese
- Nov. 2013, Gan to kagaku ryoho. Cancer & chemotherapy, 40(12) (12), 1741 - 1743[A case involving long-term survival following bile duct cancer with para-aortic lymph node metastasis that was treated by multidisciplinary therapy].[Refereed]
- Nov. 2013, Gan to kagaku ryoho. Cancer & chemotherapy, 40(12) (12), 1744 - 1746[A case of initially unresectable gallbladder cancer with surgical resection after chemotherapy with gemcitabine].[Refereed]
- Nov. 2013, Gan to kagaku ryoho. Cancer & chemotherapy, 40(12) (12), 1822 - 1824[The role of preoperative percutaneous isolated hepatic perfusion and hepatectomy in multidisciplinary treatment].[Refereed]
- Nov. 2013, Gan to kagaku ryoho. Cancer & chemotherapy, 40(12) (12), 1893 - 1896[A case of metachronous pancreatic cancer that developed 4 years after initial pancreatectomy].[Refereed]
- (一社)日本腹部救急医学会, Nov. 2013, 日本腹部救急医学会雑誌, 33(7) (7), 1097 - 1102, Japanese[Refereed]
- (一社)日本消化器外科学会, Nov. 2013, 日本消化器外科学会雑誌, 46(11) (11), 840 - 846, Japanese[Refereed]
- Nov. 2013, Hepatogastroenterology, 60(128) (128), 1833 - 8, EnglishThree-dimensional computed tomographic cholangiography as a novel diagnostic tool for evaluation of bile duct invasion of perihilar cholangiocarcinoma[Refereed]Scientific journal
- INTRODUCTION: Laparoscopic cholecystectomy (Lap-C) is a standard surgery for symptomatic gallbladder stones and acute or chronic cholecystitis. Resident surgeons often perform this operation early in their training, but they sometimes encounter difficulties for various technical reasons. Although encountering a gallbladder buried deep within the gallbladder bed is a common operative difficulty, literature on the subject scarcely exists. METHODS: Forty-two patients underwent Lap-C at our hospitals and were analyzed retrospectively. We defined the gallbladder bed pocket score (GBPS) as the maximum ratio between the height and width of the gallbladder bed measured based on multi-detector computed tomography (MDCT) images. GBPS and clinical factors were assessed in terms of their correlation with the time required for gallbladder dissection from the gallbladder bed. RESULTS: Of the 42 patients, 20 had histories of acute or chronic cholecystitis. The mean gallbladder dissection time was 14.9 min, and the mean GBPS was 0.43 in the coronal MDCT section and 0.56 in the sagittal section. The correlation coefficient between the GBPS and gallbladder dissection time was 0.40 (P = 0.01) in the coronal section and 0.38 (P = 0.02) in the sagittal section of the MDCT images. There was no statistically significant correlation between gallbladder dissection time and the surgeon's experience, patient's history of cholecystitis, gallstone size, or blood loss. However, GBPS > 0.4 predicted more difficult and prolonged dissection. CONCLUSION: GBPS is a useful tool for preoperatively predicting the time needed to dissect the gallbladder from the gallbladder bed during Lap-C. Cases with GBPS < 0.4 seem more suitable for resident surgeons who are performing gallbladder dissection early in their Lap-C training.Nov. 2013, Asian J Endosc Surg, 6(4) (4), 285 - 91, English, Domestic magazine[Refereed]Scientific journal
- Oct. 2013, HEPATOLOGY, 58, 785A - 785A, EnglishBack flow thrombectomy and PIHP for the treatment of multiple bilobular HCC with Vp4 PVTT
- Oct. 2013, HEPATOLOGY, 58, 781A - 781A, EnglishUsefulness of 99mTc-GSA scintigraphy on preoperative evaluation of liver function for hepatectomy
- 日本臨床外科学会, Oct. 2013, 日本臨床外科学会雑誌, 74(増刊) (増刊), 366 - 366, Japanese再発癌の治療戦略(肝・胆・膵) 残膵癌に対する治療戦略
- PURPOSE: To ascertain the role of respiratory-gated PET/CT with (18)F-fluorodeoxyglucose ((18)F-FDG) for accurate diagnosis of liver metastasis. MATERIALS AND METHODS: Forty patients with suspected liver metastasis underwent conventional whole-body PET/CT scan initially, followed by respiratory-gated PET/CT scan covering the liver. Visual detectability (using a 5-point confidence scale), maximum standardized uptake value (SUVmax) and metabolic tumor volume (MTV) of hepatic metastatic lesions were assessed for three data sets including ordinary whole-body (WB) scan, and non-respiratory-gated (nRG) and respiratory-gated (RG) scans. Results of enhanced CT and/or MRI, or clinical and radiological follow-up were used for reference. RESULTS: Sixteen of the patients were found to have 53 metastatic lesions in the liver. Patient-based accuracy of WB, nRG, and RG was 92.5%, 95.0%, and 97.5%, respectively, with a lesion-based detection rate of 67.9%, 73.6%, and 73.6%, respectively. The average SUVmax of 34 liver metastatic lesions for WB, nRG, and RG was 6.60 ± 2.34, 7.19 ± 2.66, and 8.08 ± 3.24, respectively. SUVmax for RG was significantly higher than that for WB (p=0.0069). The average MTV of these 40 lesions for the three protocols was 5.32 ± 4.78 cm(3), 5.07 ± 4.73 cm(3), and 4.73 ± 4.67 cm(3), respectively. Among the three protocols, RG showed the best visual and quantitative evaluation for diagnosis of liver metastasis. CONCLUSION: Respiratory-gated PET/CT allows more accurate identification of liver metastases than non-respiratory-gated PET/CT.Oct. 2013, Eur J Radiol, 82(10) (10), 1696 - 701, English, International magazine[Refereed]Scientific journal
- 日本膵・胆管合流異常研究会, Sep. 2013, 日本膵・胆管合流異常研究会プロシーディングス, 36, 65 - 65, Japanese胆嚢癌切除後経過中に遺残膵内胆管癌を発症した膵・胆管合流異常の一例[Refereed]
- 日本臨床外科学会, Jul. 2013, 日本臨床外科学会雑誌, 74(7) (7), 1988 - 1992, Japanese[Refereed]
- (一社)日本肝胆膵外科学会, Jun. 2013, 日本肝胆膵外科学会・学術集会プログラム・抄録集24回, 25回, 308 - 308, Japanese膵空腸吻合法 膵頭十二指腸切除術における安全・確実な膵空腸吻合手術手技[Refereed]
- Elsevier BV, Jun. 2013, Clin Gastroenterol Hepatol, 11(6) (6), 712 - 8, English[Refereed]Scientific journal
- (株)総合医学社, Jun. 2013, 消化器外科学レビュー2013-'14, 2013-'14, 71 - 78, Japanese肝疾患 肝細胞癌[Refereed][Invited]
- (株)オプトロニクス社, Apr. 2013, Medical Photonics, (13) (13), 11 - 15, Japanese
- Lymphadenectomy combined with locoregional treatment for multiple advanced hepatocellular carcinoma with lymph node metastasesLymphadenectomy of lymph node metastasis (LNM) from hepatocellular carcinoma (HCC) may potentially improve survival of patients with intrahepatic tumors controllable by means of locolegional treatment. However, the treatment strategy has not gained wide clinical acceptance, especially in patients with multiple advanced HCC. Thus, the purpose of this study is to evaluate the role of lymphadenectomy combined with locoregional treatment for the management of multiple advanced HCC with LNM. Between January 1998 and August 2012, 15 patients underwent a selective lymphadenectomy either concurrently or sequentially after hepatectomy. Seven of 15 patients underwent reductive hepatectomy while the remaining 8 patients had hepatectomy at curative intent. In patients with reductive hepatectomy, lymphadenectomy was concurrently performed and the residual intrahepatic tumors were treated thereafter with additional locoregional treatments consisting of transcatheter arterial chemoembolization, radiofrequency ablation, and percutaneous isolated hepatic perfusion. Only 4 patients (26.6%) of 15 patients developed lymph node recurrence. However, intrahepateic recurrence was encountered in 13 of 15 patients. The median survival time after lymphadenectomy was 25.2 months with the overall survival rates at 1, 2, and 3 years being 76.9%, 52.7%, and 26.4%, respectively. Selective lymphadenectomy and multimodal locoregional treatment in patients with multiple residual tumors exhibited a similar overall survival to complete resection of LNM and intrahepatic tumors (P=0.78). Lymphadenectomy combined with an additional aggressive locoregional treatments may be justified in selected patients with multiple advanced HCC with LNM.Apr. 2013, Kobe J Med Sci, 59(1) (1), E17 - 27, English, Domestic magazine[Refereed]Research institution
- Mar. 2013, Surgery, 153(3) (3), 434 - 6, English, International magazineScientific journal
- 2013, Int J Hepatol, 2013, 849290, EnglishQuantification of pregenomic RNA and covalently closed circular DNA in hepatitis B virus-related hepatocellular carcinoma[Refereed]Scientific journal
- The purpose of this study was to assess the efficacy of arterial-dominant phase images of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (EOB)-enhanced magnetic resonance imaging (MRI) for evaluation of arterial blood supply in hepatocellular carcinoma (HCC) in comparison with that of multiphasic dynamic computed tomography (CT). This study comprised 30 patients (22 men and 8 women, mean age: 68.0 years) with 40 pathologically proven HCCs (well differentiated: 3, moderately differentiated: 30, poorly differentiated: 7, mean diameter: 45.1 mm), all of whom underwent EOB-enhanced MRI and dynamic CT preoperative assessment. Regions of interest were placed over HCCs and the adjacent normal liver, and signal intensities or CT values were measured by two experienced abdominal radiologists on the arterial-dominant phase images of EOB-enhanced MRI and dynamic CT images. HCC-to-liver contrasts [Michelson's contrast: C(M)=(S(HCC)-S(Liver))/(S(HCC)+S(Liver))] were calculated and compared among the modalities. HCC-to-liver contrasts were also visually scored on a 5-point scale and compared. The mean C(M) and visual score for dynamic CT were significantly higher than those for EOB-enhanced MRI. Good agreements were obtained among the two observers. Dynamic CT is a more suitable modality than EOB-enhanced MRI for evaluation of arterial blood supply in HCC. This should be taken into account for diagnosis and management of HCC.Jan. 2013, Magn Reson Imaging, 31(1) (1), 17 - 22, English, International magazine[Refereed]Scientific journal
- 2013, 肝癌診療Q&A, 252 - 257, Japanese門脈浸潤があっても外科切除の価値があるのはどのような症例でしょうか?
- Jan. 2013, Frontiers in Gastroenterology, 18(1号) (1号), 26 - 32, Japanese誌上ディベート IPMNの手術適応をめぐって 積極的に手術を進めるべきとする立場から[Invited]
- 南江堂, Jan. 2013, 外科, 75(1号) (1号), 49 - 53, Japanese【癌治療の選択-治療効果と治療費】 胆道癌の治療効果と治療費[Refereed][Invited]
- (一社)日本内視鏡外科学会, Dec. 2012, 日本内視鏡外科学会雑誌, 17(7) (7), 557 - 557, Japanese腹腔鏡下尾側膵切除術 導入と術式の定型化へ向けて[Refereed]
- (一社)日本内視鏡外科学会, Dec. 2012, 日本内視鏡外科学会雑誌, 17(7) (7), 557 - 557, Japanese腹腔鏡下尾側膵切除術における術中出血への対策[Refereed]
- (一社)日本内視鏡外科学会, Dec. 2012, 日本内視鏡外科学会雑誌, 17(7) (7), 236 - 236, Japanese低侵襲手術ナビゲーション最前線 Virtual 3D画像と臓器立体モデル 肝臓外科領域における当科の術前シミュレーション・術中ナビゲーションの取り組み[Refereed]
- (株)医薬情報研究所, Dec. 2012, 新薬と臨床, 61(12号) (12号), 2677 - 2677, Japanese[Refereed]Research society
- (一社)日本内視鏡外科学会, Dec. 2012, 日本内視鏡外科学会雑誌, 17(7) (7), 615 - 615, Japanese肝硬変症例に対する腹腔鏡下胆嚢摘出術の成績[Refereed]
- INTRODUCTION: Pancreatogenic diabetes after pancreatectomy is of growing importance due to the increasing life expectancy of pancreatectomized patients. Although reduction of pancreatic volume is thought to affect glucose metabolism, a consistent relationship has yet to be determined. This study aimed to investigate functional consequences of distal pancreatectomy (DP) in preoperatively non-diabetic patients. METHODS: This study included 61 non-diabetic patients who underwent DP. Clinical data were obtained, and the percent resected volume (PRV) of each pancreas was determined via multi-detector row computed tomography volumetry. RESULTS: During the follow-up period (median 26 months), 22 patients (36 %) developed new-onset diabetes within a median onset time of 8 months (range 0.5-42 months) postoperatively. The remaining 39 patients also showed impaired glucose metabolism. Multivariate analysis identified preoperative hemoglobin A1c ≥ 5.7 % (odds ratio 15.6, p = 0.001) and PRV > 44 % (odds ratio 11.3, p = 0.004) as independent risk factors for new-onset diabetes. CONCLUSIONS: Key determinants of postoperative glycemic control include preoperative functional reserve of the endocrine pancreas and the volume reduction of pancreatic parenchyma. Our findings enable reliable preoperative evaluation of the risk of postoperative diabetes and appropriate postoperative surveillance, which is helpful for early intervention in high risk patients.Dec. 2012, J Gastrointest Surg, 16(12) (12), 2212 - 9, English, International magazine[Refereed]Scientific journal
- Dec. 2012, 手術, 66(13号) (13号), 1853 - 1859, Japanese【消化器癌拡大手術の最新手技】 高度脈管浸潤を伴う肝細胞癌に対する拡大手術
- Nov. 2012, Gan to kagaku ryoho. Cancer & chemotherapy, 39(12) (12), 1825 - 1827[A case of bilobar multiple hepatocellular carcinoma in which complete remission was achieved by preoperative percutaneous isolated hepatic perfusion and subsequent hepatectomy].[Refereed]
- Nov. 2012, Gan to kagaku ryoho. Cancer & chemotherapy, 39(12) (12), 1886 - 1888[A case of postoperative liver metastasis from pancreatic carcinoma treated with percutaneous isolated hepatic perfusion(PIHP)].[Refereed]
- Nov. 2012, Gan to kagaku ryoho. Cancer & chemotherapy, 39(12) (12), 2122 - 2124[Long-term survival in 2 cases with unresectable hilar bile duct cancer and sclerosing cholangitis].[Refereed]
- (株)癌と化学療法社, Nov. 2012, 癌と化学療法, 39(12) (12), 1886 - 1888, Japanese[Refereed]
- (株)癌と化学療法社, Nov. 2012, 癌と化学療法, 39(12) (12), 2158 - 2160, Japanese[Refereed]
- (株)癌と化学療法社, Nov. 2012, 癌と化学療法, 39(12) (12), 1825 - 1827, Japanese[Refereed]
- (株)癌と化学療法社, Nov. 2012, 癌と化学療法, 39(12) (12), 2122 - 2124, Japanese[Refereed]
- (株)癌と化学療法社, Nov. 2012, 癌と化学療法, 39(12) (12), 1877 - 1879, Japanese[Refereed]
- Nov. 2012, Gan To Kagaku Ryoho, 39(12) (12), 1877 - 9, JapaneseThree cases of recurrent bile duct cancer diagnosed and treated by double-balloon endoscopy[Refereed]Scientific journal
- BACKGROUND: Routine performance of intraoperative cholangiography (IOC) during cholecystectomy is controversial. The aim of this study was to evaluate the role of IOC during cholecystectomy in addition to preoperative magnetic resonance cholangiopancreatography (MRCP) in our institution over a 12-year period. METHODS: A total of 425 consecutive patients who underwent IOC during cholecystectomy were included in this study. MRCP was performed preoperatively for bile duct evaluation in all patients. When common bile duct (CBD) stones were detected, they were removed endoscopically before the operation. We estimated the results of IOC in terms of the success rate, the detection rate of anatomic abnormality of the biliary system, and the incidence of residual CBD stones. RESULTS: MRCP preoperatively identified 6 (1.4 %) patients with abnormal biliary systems and 56 with CBD stones, which were endoscopically removed. The success rate of IOC was 93.8 % (399/425). Abnormalities of the biliary system were detected in 12 patients (12/399, 3.0 %) and CBD stones in 8 (8/399, 2.0 %). Of the eight patients with stones, seven had been examined by endoscopy preoperatively and found to have CBD stones. The detection rate of bile duct stones in patients with preoperative endoscopic removal of CBD stones (7/56, 12.5 %) was significantly higher than those with CBD stones first detected during IOC (1/365, 0.3 %) (p < 0.01). Moreover, no residual CBD stones were detected in patients who were operated on within fewer than 12 days from endoscopic treatment to the operation. CONCLUSIONS: IOC is indicated even after preoperative sphincterotomy for CBD stones. In our study, it resulted in a 12.5 % incidence of persistent stones after sphincterotomy. IOC plays an additional role in detecting CBD stones and in revealing abnormalities of the biliary tree in patients whose biliary tree was preoperatively evaluated by MRCP.Nov. 2012, World J Surg, 36(11) (11), 2661 - 5, English, International magazine[Refereed]Scientific journal
- Feasibility of (18)F-fluorodeoxyglucose positron-emission tomography for preoperative evaluation of biliary tract cancer(18)F-Labeled fluorodeoxyglucose positron-emission tomography (FDG-PET), a rapidly evolving functional imaging modality, has recently been shown to be useful in the diagnosis and staging of various malignant tumors due to focal uptake of FDG-labeled glucose in malignant cell populations. However, the role of FDG-PET in the diagnosis and staging of biliary tract cancer is still controversial and has not yet been fully evaluated. The aim of this study was to determine the clinical importance of FDG-PET in the preoperative evaluation of biliary tract cancer and retrospectively clarify the characteristics of false-negative and false-positive cases. We retrospectively analyzed data for 73 consecutive patients diagnosed with cancer of the biliary tract and were admitted to the Department of Hepato-Biliary-Pancreatic Surgery at Kobe University Hospital for treatment, from January 2007 to August 2009. Since the sensitivity, specificity and positive predictive value (PPV) of FDG-PET in the diagnosis of bile duct carcinoma are usually relatively high, FDG-PET is considered to be a useful tool in diagnosing biliary tract cancer. FDG-PET also seems to be useful in clinical decision-making, regarding treatment strategy, including surgery. Our results showed that FDG-PET is highly sensitive in delineating the primary focus of biliary cancer and is a useful tool in preoperative examination. A disadvantage of FDG-PET is its inability to indicate small metastases and false-positive findings of inflamed gallbladder and bile duct lesions.Nov. 2012, Anticancer Res, 32(11) (11), 5105 - 10, English, International magazine[Refereed]Scientific journal
- Nov. 2012, Dig Endosc, 24(6) (6), 484 - 484, English, International magazine[Refereed]Scientific journal
- Nov. 2012, Gan To Kagaku Ryoho, 39(12) (12), 2158 - 60, JapaneseA case of interstitial lung disease associated with gemcitabine treatment in a patient with locally advanced pancreatic cancer following proton beam radiotherapy[Refereed]Scientific journal
- Nov. 2012, 外科, 74(12号) (12号), 1386 - 1389, Japanese【手術前に必読 局所解剖】 肝・胆・膵・脾の手術 胆嚢癌手術に必要な局所解剖[Invited]
- Oct. 2012, 日本臨床外科学会雑誌, 73(増刊) (増刊), 447, Japanese膵切除における手術手技の工夫(生食滴下式バイポーラを用いた手術手技)[Refereed]Research society
- Oct. 2012, 日本臨床外科学会雑誌, 73(増刊) (増刊), 557, Japanese膵癌鑑別診断および術前診断におけるFDG-PETの位置づけ[Refereed]Research society
- Oct. 2012, 日本癌治療学会誌, 47(3号) (3号), 1010, Japanese膵癌の診断・治療方針決定におけるFDG-PETの有用性の検討[Refereed]Research society
- 日本臨床外科学会, Oct. 2012, 日本臨床外科学会雑誌, 73(増刊) (増刊), 501 - 501, Japanese門脈腫瘍栓(Vp4)合併肝細胞癌に対する肝切除の工夫と集学的治療としてのPIHPの有効性[Refereed]Research society
- Oct. 2012, 日本臨床外科学会雑誌, 73(増刊) (増刊), 417, Japanese腹腔鏡下膵切除術 腹腔鏡下尾側膵切除術 安全な術式の定型化[Refereed]Research society
- Oct. 2012, 日本臨床外科学会雑誌, 73(増刊) (増刊), 775, Japanese当院における単孔式腹腔鏡下胆嚢摘出術の成績[Refereed]Research society
- 日本臨床外科学会, Oct. 2012, 日本臨床外科学会雑誌, 73(増刊) (増刊), 925 - 925, Japanese胆嚢癌との鑑別診断が困難であった黄色肉芽腫性胆嚢炎の1例[Refereed]
- Oct. 2012, 日本臨床外科学会雑誌, 73(増刊) (増刊), 565, Japanese切除断端、断端距離から見た肝内胆管癌の手術戦略[Refereed]Research society
- Oct. 2012, 日本癌治療学会誌, 47(3号) (3号), 2396, Japanese集学的治療により長期生存を得ている大動脈周囲リンパ節転移陽性胆管癌の1例[Refereed]Research society
- Oct. 2012, 日本臨床外科学会雑誌, 73(増刊) (増刊), 459, Japanese主膵管型IPMNに対する術前診断と術式選択[Refereed]Research society
- Oct. 2012, 日本臨床外科学会雑誌, 73(増刊) (増刊), 526, Japanese細径膵管例における確実な膵空腸吻合手術手技[Refereed]Research society
- Oct. 2012, 日本臨床外科学会雑誌, 73(増刊) (増刊), 771, Japanese肝門部胆管癌の術前診断で切除したIgG4関連硬化性胆管炎の1例[Refereed]Research society
- 篠原出版新社, Oct. 2012, 癌の臨床, 58(5号) (5号), 273 - 279, Japanese【化学療法の進歩に伴う進行膵胆道癌の手術適応】 非切除胆道癌に対し化学療法施行後に切除に至った症例の検討[Refereed][Invited]Scientific journal
- 日本臨床外科学会, Oct. 2012, 日本臨床外科学会雑誌, 73(増刊) (増刊), 627 - 627, Japaneseソナゾイドによる術中超音波胆道造影を用いた肝切除術[Refereed]Research society
- Oct. 2012, 日本臨床外科学会雑誌, 73(増刊) (増刊), 760, JapaneseHepatomesenteric typeの肝動脈走行変異を伴う十二指腸乳頭部癌に対してSSPPDを施行した1例[Refereed]Research society
- 日本臨床外科学会, Oct. 2012, 日本臨床外科学会雑誌, 73(増刊) (増刊), 504 - 504, JapaneseHanging maneuverを用いた巨大肝細胞癌に対する安全な肝右肝切除術[Refereed]Research society
- Sep. 2012, 日本消化器病学会雑誌, 109(臨増大会) (臨増大会), A749, Japanese膵癌に対する陽子線治療効果判定におけるFDG-PETの有用性[Refereed]Research society
- Sep. 2012, 移植, 47(総会臨時) (総会臨時), 182, Japanese門脈血栓症を合併した症例に対する門脈再建術の検討[Refereed]Research society
- Sep. 2012, 日本膵・胆管合流異常研究会プロシーディングス, 35, 49 - 50, Japanese非拡張型膵・胆管合流異常に肝門部胆管癌、胆嚢癌の重複癌を合併した一例[Refereed]Research society
- Sep. 2012, 移植, 47(4-5) (4-5), 343 - 344, Japanese生体肝移植患者と移植に至らなかった患者の不適応要因Research society
- Sep. 2012, 移植, 47(総会臨時) (総会臨時), 310, Japaneseグラフト脾動脈・上腸間膜動脈血栓をきたした膵腎同時移植の1生着例[Refereed]Research society
- Sep. 2012, 消化器内科, 55(3号) (3号), 372 - 375, Japanese【非切除胆道癌の治療】 胆道癌に対するR2手術 化学療法[Refereed][Invited]
- Aug. 2012, 胆道, 26(3号) (3号), 436, Japanese早期乳頭部癌の臨床的特徴と治療[Refereed]Research society
- Aug. 2012, 胆道, 26(3号) (3号), 450, Japanese肝外胆管癌に対する肝外胆管切除術の成績[Refereed]Research society
- Jul. 2012, 肝臓, 53(7号) (7号), 432 - 433, Japanese腹腔鏡下ラジオ波焼灼術におけるNon-Trocar Techniqueの有用性[Refereed]Scientific journal
- Jun. 2012, 腫瘍内科, 9(6号) (6号), 688 - 691, Japanese【肝・胆・膵腫瘍の薬物療法-最近の進歩】 胆道がん 術後補助療法の現状と課題[Refereed][Invited]Scientific journal
- Jun. 2012, Hepatology research, 42(6) (6), 574 - 82, EnglishDistinctive expression of CD133 between intraductal papillary neoplasms of the bile duct and bile duct adenocarcinomas[Refereed]Scientific journal
- May 2012, 膵臓, 27(3号) (3号), 338, Japanese膵切除の合併症とその対処法 膵頭十二指腸切除術後出血例に対する治療選択と成績[Refereed]Research society
- May 2012, 日本肝胆膵外科学会・学術集会プログラム・抄録集24回, 520, Japanese膵腫瘍核手術 手技の工夫と術後膵機能[Refereed]Research society
- May 2012, 日本肝胆膵外科学会・学術集会プログラム・抄録集24回, 448, Japanese膵腫瘍に対する鏡視下尾側膵切除術[Refereed]Research society
- May 2012, 日本肝胆膵外科学会・学術集会プログラム・抄録集24回, 373, Japanese膵癌術後5年目に出現した超高齢者の残膵癌に対し、粒子線治療を施行した一例[Refereed]Research society
- May 2012, 日本肝胆膵外科学会・学術集会プログラム・抄録集24回, 422, Japanese膵・胆管合流異常を伴わない20代の肝門部胆管癌の一切除例[Refereed]Research society
- May 2012, 膵臓, 27(3号) (3号), 311, Japanese腹腔鏡下膵手術の現況 膵腫瘍に対する腹腔鏡下尾側膵切除術[Refereed]Research society
- May 2012, 日本肝胆膵外科学会・学術集会プログラム・抄録集24回, 302, Japanese腹腔鏡下ラジオ波焼灼術におけるNon Trocar Techniqueの有用性[Refereed]Research society
- May 2012, 日本肝胆膵外科学会・学術集会プログラム・抄録集24回, 298, Japanese脳死下膵腎同時移植における血行再建術[Refereed]Research society
- May 2012, 日本肝胆膵外科学会・学術集会プログラム・抄録集24回, 412, Japanese肉腫成分を含む肝内胆管癌および混合型肝癌の2例[Refereed]Research society
- May 2012, 日本肝胆膵外科学会・学術集会プログラム・抄録集24回, 290, Japanese当施設におけるmodified Hanging Maneuverを用いた肝葉切除の工夫[Refereed]Research society
- May 2012, 日本肝胆膵外科学会・学術集会プログラム・抄録集24回, 175, Japanese胆嚢と総胆管の内視鏡外科 Lap-Cのpit fallと対策 腹腔鏡下胆嚢摘出術における術中胆道損傷例の特徴とその対処に関する検討[Refereed][Invited]Research society
- May 2012, 日本肝胆膵外科学会・学術集会プログラム・抄録集24回, 435, Japanese胆道再々建術施行例の背景疾患と手術成績の検討[Refereed]Research society
- May 2012, 日本肝胆膵外科学会・学術集会プログラム・抄録集24回, 274, Japanese切除例の解析からみたIPMNの治療戦略[Refereed]Research society
- May 2012, 日本肝胆膵外科学会・学術集会プログラム・抄録集24回, 436, Japanese心血管疾患合併患者の胆嚢摘出術例の検討[Refereed]Research society
- May 2012, 日本肝胆膵外科学会・学術集会プログラム・抄録集24回, 197, Japanese肝胆膵領域の外科治療 これまでの到達点、これからの課題 肝門部胆管癌の切除方法 脈管合併切除とアプローチ 肝門部胆管癌門脈合併切除例の検討[Refereed]Research society
- May 2012, 日本肝胆膵外科学会・学術集会プログラム・抄録集24回, 207, Japanese肝切除における残肝体積と予備能のコンセンサス再考 肝細胞癌における術式選択 幕内基準を超えて[Refereed]Research society
- May 2012, 胆と膵, 33(5号) (5号), 427 - 432, Japanese【膵疾患診療におけるFDG-PETの有用性】 膵癌に対する陽子線治療効果判定におけるFDG-PETの有用性[Refereed][Invited]Scientific journal
- May 2012, 胆道, 26(2号) (2号), 231 - 236, Japaneseリンパ節・卵巣転移を伴った若年女性のIntraductal Papillary Neoplasm of Bile Duct (IPNB) の1例[Refereed]Scientific journal
- May 2012, 膵臓, 27(3号) (3号), 462, JapaneseTNM分類と腫瘍細胞増殖動態からみた膵神経内分泌腫瘍(P-NET)術後再発例の検討[Refereed]Research society
- May 2012, 膵臓, 27(3号) (3号), 391, JapaneseStage 0ならびにStage I膵癌切除症例の検討[Refereed]Research society
- May 2012, 日本肝胆膵外科学会・学術集会プログラム・抄録集24回, 263, JapaneseCT所見とERC/IDUS所見の乖離により診断に難渋した進行胆嚢癌疑いの1例[Refereed]Research society
- May 2012, 日本肝胆膵外科学会・学術集会プログラム・抄録集24回, 249, JapaneseBorderline resectable膵癌切除例の検討と今後の展望[Refereed]Research society
- 南江堂, May 2012, 外科, 74(5号) (5号), 530 - 534, Japanese【膵癌update 2012】 治療 最新の膵癌粒子線治療[Refereed][Invited]
- May 2012, 肝胆膵画像, 14(3号) (3号), 212 - 220, Japanese【肝癌-治療計画・支援のための画像診断】 各論 肝細胞癌の術前画像診断 脈管浸潤を伴う肝細胞癌 腫瘍栓合併肝細胞癌の診断とその切除限界
- Apr. 2012, 肝臓, 53(Suppl.1) (Suppl.1), A418, Japanese腹腔鏡下ラジオ波焼灼術におけるNon Trocar Techniqueの有用性[Refereed]Research society
- Apr. 2012, 肝臓, 53(Suppl.1) (Suppl.1), A469, Japanese神経内分泌腫瘍肝転移に対する肝切除例の検討Research society
- Apr. 2012, 肝臓, 53(Suppl.1) (Suppl.1), A212, Japanese肝癌化学療法 進行肝細胞癌治療における経皮的肝灌流(PIHP)の位置付け さらなる成績の向上を目指してResearch society
- Apr. 2012, 肝臓, 53(Suppl.1) (Suppl.1), A160, Japanese肝移植後ウイルス性肝炎の現状と対応 C型肝炎肝硬変患者に対する移植後リバビリン・インターフェロン少量長期投与の有効性[Refereed]Research society
- Apr. 2012, 超音波医学, 39(Suppl.) (Suppl.), S410, JapaneseEPSガイド下に腫瘍核出術を施行し得た膵頭部Solid-pseudopapillary neoplasmの1例[Refereed]Research society
- Intraductal papillary mucinous neoplasm (IPMN) of the pancreas is a distinct entity characterized by papillary proliferations of mucin-producing epithelial cells with excessive mucin production and cystic dilatation of the pancreatic ducts. The clinical presentation often involves recurrent episodes of pancreatitis associated with the temporal obstruction of the main pancreatic duct caused by the hypersecretion of mucin. We herein describe a case in which the patient repeatedly experienced the occurrence of idiopathic acute pancreatitis in the head of the pancreas over a 9-year period, and who was ultimately was cured by distal pancreatectomy for IPMNs in the pancreatic tail. This case illustrates the potential pitfalls in the diagnosis of IPMNs owing to a discrepancy between the site of pancreatitis and that of the IPMN. The possible mechanisms linking acute pancreatitis with the formation of IPMNs are also reviewed.Apr. 2012, Surgery today, 42(4) (4), 398 - 402, English, Domestic magazineScientific journal
- Mar. 2012, 日本外科学会雑誌, 113(臨増2) (臨増2), 570, Japanese膵癌術後補助化学療法の再検討と課題[Refereed]Research society
- Mar. 2012, 日本外科学会雑誌, 113(臨増2) (臨増2), 328, Japanese尾側膵切除後糖尿病の危険因子の解析[Refereed]Research society
- Mar. 2012, 日本外科学会雑誌, 113(臨増2) (臨増2), 686, Japanese中上部胆管癌に対する胆管切除の検討[Refereed]Research society
- Mar. 2012, 日本外科学会雑誌, 113(臨増2) (臨増2), 557, Japanese胆嚢摘出時における術中胆道造影の意義[Refereed]Research society
- Mar. 2012, 日本外科学会雑誌, 113(臨増2) (臨増2), 390, Japanese代謝酵素測定による胆道癌術後GEM補助投与の効果予測の検討Research society
- Mar. 2012, 日本外科学会雑誌, 113(臨増2) (臨増2), 384, Japanese生体肝移植後腎機能障害に対する予測式を用いた新たな治療戦略[Refereed]Research society
- Mar. 2012, 日本外科学会雑誌, 113(臨増2) (臨増2), 456, Japanese主膵管近接腫瘍に対する膵腫瘍核出術の適応と手術手技の工夫[Refereed]Research society
- Mar. 2012, 日本外科学会雑誌, 113(臨増2) (臨増2), 163, Japanese肝細胞癌の治療戦略 その進歩と今後の方向性 高度進行肝癌に対する減量肝切除とPIHPによる2段階治療の有効性と予後因子の解析[Refereed]Research society
- Mar. 2012, 日本消化器外科学会雑誌, 45(3号) (3号), 282 - 289, Japanese肝外胆管原発のいわゆる癌肉腫の1例[Refereed]Scientific journal
- Mar. 2012, 日本外科学会雑誌, 113(臨増2) (臨増2), 191, Japanese化学療法の進歩に伴う進行膵胆道癌の手術適応 非切除胆道癌に対し化学療法施行後に切除に至った症例の検討[Refereed]Research society
- Mar. 2012, 膵・胆道癌Frontier, 2(1号) (1号), 46 - 47, Japaneseゲムシタビン併用陽子線治療を行い3年以上の生存が得られている局所進行切除不能膵癌の1例[Refereed][Invited]Scientific journal
- Mar. 2012, 日本消化器病学会雑誌, 109(臨増総会) (臨増総会), A257, JapaneseIPMN外科治療における縮小手術の位置づけ[Refereed]Research society
- Mar. 2012, 消化器外科学レビュー, 2012, 73 - 79, Japanese肝疾患 肝細胞癌
- Mar. 2012, 胆と膵, 33(3号) (3号), 249 - 254, Japanese【十二指腸乳頭部癌-診断・治療の最前線-】 早期乳頭部癌の臨床的特徴と治療[Refereed][Invited]
- Feb. 2012, 日本腹部救急医学会雑誌, 32(2号) (2号), 402, Japanese腸回転異常症に伴う回盲部軸捻転の1例[Refereed]Research society
- Feb. 2012, 日本腹部救急医学会雑誌, 32(2号) (2号), 395, Japanese抗凝固薬内服患者に対する腹腔鏡下胆嚢摘出術施行例の検討Research society
- Feb. 2012, 日本腹部救急医学会雑誌, 32(2号) (2号), 453, Japanese急性胆嚢炎、胆汁性腹膜炎の術前診断で緊急手術を施行したうっ血性肝障害の1例[Refereed]Research society
- Feb. 2012, 日本腹部救急医学会雑誌, 32(2号) (2号), 526, Japanese肝門部胆管癌術後仮性動脈瘤出血の1例Research society
- Feb. 2012, 日本腹部救急医学会雑誌, 32(2号) (2号), 526, JapaneseERCP後重症急性膵炎を併発した胆管癌に対し膵頭十二指腸切除術後、特異な再発形態を呈した1例Research society
- 南江堂, Feb. 2012, 外科, 74(2号) (2号), 115 - 120, Japanese【肝細胞癌update 2012】 肝細胞癌の疫学
- 2012, Japanese Journal of Gastroenterological Surgery, 45(3) (3), 282 - 289, Japanese[Refereed]Scientific journal
- 2012, Dig Dis, 30(6) (6), 588 - 91, EnglishNovel non-trocar technique for laparoscopic radiofrequency ablation[Refereed]Scientific journal
- Jan. 2012, 臨床外科, 67(1号) (1号), 54 - 58, Japanese【「切除困難例」への化学療法後の手術-根治切除はどこまで可能か】 肝癌に対する術前化学療法
- INTRODUCTION AND BACKGROUND: Autoimmune pancreatitis (AIP) is a rare disease that closely mimics pancreatic cancer (PC) in its presentation. It is very important for clinicians to distinguish one from the other because their treatment and prognosis are vastly different. Typical radiological imaging findings, in particular observation of diffusely or segmentally narrowed main pancreatic duct (MPD) with an irregular wall by endoscopic retrograde cholangiopancreatography (ERCP), are essential for making the diagnosis of AIP. On the other hand, MPD obstruction is one of the most frequent features on ERCP. CASE REPORT: We report a rare case of a patient with focal mass-forming AIP strongly suspected of being PC because of MPD obstruction on ERCP. CONCLUSION: It was difficult to distinguish PC from AIP with current diagnostic modalities. We will continue to make an effort to distinguish between the two disorders to prevent unnecessary surgery.Dec. 2011, Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 15(12) (12), 2296 - 2298, English, International magazine[Refereed]Scientific journal
- Dec. 2011, 日本内視鏡外科学会雑誌, 16(7号) (7号), 369, Japanese腹腔鏡補助下膵体尾部切除における困難症例の検討[Refereed]Research society
- Dec. 2011, 日本内視鏡外科学会雑誌, 16(7号) (7号), 496, Japanese腹腔鏡下膵腫瘍核出術を施行したindeterminate mucin-producing cystic neoplasmの1例[Refereed]Research society
- Dec. 2011, 日本内視鏡外科学会雑誌, 16(7号) (7号), 185, Japanese肝胆膵脾良性疾患に対する内視鏡外科の適応 腹腔鏡下膵切除術における適応と手技[Refereed]Research society
- Dec. 2011, 日本内視鏡外科学会雑誌, 16(7号) (7号), 585, JapaneseIPMNに対する腹腔鏡手術の適応[Refereed]Research society
- Nov. 2011, Gan to kagaku ryoho. Cancer & chemotherapy, 38(12) (12), 2065 - 2067[A case report of multiple advanced hepatocellular carcinomas treated by combination therapy with hepatectomy and particle therapy].[Refereed]
- (株)南江堂, Nov. 2011, 外科, 73(12) (12), 1396 - 1400, Japanese【外科医が知っておくべき徴候と症候群】 胆道 Lemmel症候群とMirizzi症候群
- (株)癌と化学療法社, Nov. 2011, 癌と化学療法, 38(12) (12), 2065 - 2067, Japanese
- Nov. 2011, Gan to kagaku ryoho. Cancer & chemotherapy, 38(12) (12), 2030 - 2032[A case report of intrahepatic cholangiocarcinoma diagnosed as lung cancer with liver metastasis treated with radiofrequency ablation].[Refereed]
- BACKGROUND: The objective of this study was to evaluate the clinical outcome of proton and carbon ion therapy for hepatocellular carcinoma (HCC). METHODS: In total, 343 consecutive patients with 386 tumors, including 242 patients (with 278 tumors) who received proton therapy and 101 patients (with 108 tumors) who received carbon ion therapy, were treated on 8 different protocols of proton therapy (52.8-84.0 gray equivalents [GyE] in 4-38 fractions) and on 4 different protocols of carbon ion therapy (52.8-76.0 GyE in 4-20 fractions). RESULTS: The 5-year local control and overall survival rates for all patients were 90.8% and 38.2%, respectively. Regarding proton and carbon ion therapy, the 5-year local control rates were 90.2% and 93%, respectively, and the 5-year overall survival rates were 38% and 36.3%, respectively. These rates did not differ significantly between the 2 therapies. Univariate analysis identified tumor size as an independent risk factor for local recurrence in proton therapy, carbon ion therapy, and in all patients. Multivariate analysis identified tumor size as the only independent risk factor for local recurrence in proton therapy and in all patients. Child-Pugh classification was the only independent risk factor for overall survival in proton therapy, in carbon ion therapy, and in all patients according to both univariate and multivariate analyses. No patients died of treatment-related toxicities. CONCLUSIONS: Proton and carbon ion therapies for HCC were comparable in terms of local control and overall survival rates. These therapies may represent innovative alternatives to conventional local therapies for HCC.Nov. 2011, Cancer, Vol. 117, No. 21, pp. 4890-904(21) (21), 4890 - 904, English, International magazine[Refereed]Scientific journal
- Oct. 2011, J Prenat Med, 5(4) (4), 93 - 96, EnglishResection of giant liver hemangioma in a pregnant woman with coagulopathy: Case report and literature review[Refereed]Scientific journal
- 医学図書出版(株), Sep. 2011, 胆と膵, 32(9) (9), 869 - 874, Japanese【膵癌診療と研究の最先端】 粒子線治療を用いた新しい膵癌治療戦略
- Sep. 2011, 手術, 65巻, 10, pp. 1515-1522, Japanese【肝胆膵高難度手術のすべて】 血管合併切除再建 下大静脈浸潤肝癌に対する肝切除
- 日本膵臓学会, Aug. 2011, 膵臓, 26(4) (4), 511 - 516, Japanese
- BACKGROUND: The prognosis of patients who have hepatocellular carcinoma (HCC) associated with inferior vena cava tumor thrombus (IVCTT) is very poor, and effective treatment modalities are extremely limited. The objective of this study was to determine the therapeutic efficacy of particle radiotherapy for HCC with IVCTT. METHODS: Between June 2001 and January 2009, 16 evaluable patients who had HCC with IVCTT were treated with particle radiotherapy. They were divided into 2 groups: 6 were treated with curative intent; 10 with palliative intent. The local tumor control rates, overall survival rates, and toxicities were evaluated. RESULTS: All tumors treated with particle radiotherapy remained controlled without local recurrence at the last follow-up. The overall survival rates for the 16 patients at 1 and 3 years were 61.1 and 36.7%, respectively. We observed a significant difference in the survival rates according to treatment policy. The median survival time was 25.4 months for patients treated with curative intent and 7.7 months for those treated with palliative intent. The one-year survival rates were 100.0 and 33.3%, respectively. No Grade 3 or higher treatment-related toxicities were observed. CONCLUSIONS: Particle radiotherapy is thought to be potentially effective and safe for HCC with IVCTT. Considering the current lack of effective and less-invasive local therapy for HCC with IVCTT, particle radiotherapy may therefore be an attractive new therapeutic approach for this type of HCC.Jul. 2011, Journal of gastroenterology, 46(7) (7), 913 - 20, English, Domestic magazineScientific journal
- 日本臨床外科学会, Jun. 2011, 日本臨床外科学会雑誌, 72(6) (6), 1531 - 1535, Japanese
- 日本膵臓学会, Apr. 2011, 膵臓, 26(2) (2), 142 - 152, Japanese
- (株)南江堂, Feb. 2011, 外科, 73(2) (2), 187 - 195, Japanese【肝胆膵領域における最新の画像診断】 肝胆膵領域におけるFDG-PETの役割
- (一社)日本消化器外科学会, Feb. 2011, 日本消化器外科学会雑誌, 44(2) (2), 123 - 130, Japanese重症急性壊死性膵炎を発症し内視鏡的乳頭括約筋切開術を行ったLemmel症候群の1例
- (株)医学書院, Jan. 2011, 肝胆膵画像, 13(1) (1), 45 - 50, Japanese
- (一財)日本消化器病学会, Nov. 2010, 日本消化器病学会雑誌, 107(11) (11), 1828 - 1834, Japanese
- (株)癌と化学療法社, Nov. 2010, 癌と化学療法, 37(12) (12), 2300 - 2302, Japanese肝切除と経皮的肝灌流(PIHP)の2段階治療(Dual Tx)が奏効したVp4門脈腫瘍栓(PVTT)を伴う肝細胞癌(HCC)の1例
- (株)癌と化学療法社, Nov. 2010, 癌と化学療法, 37(12) (12), 2312 - 2314, Japanese肝細胞癌術後リンパ節再発に対しリンパ節切除術と経皮的肝灌流化学療法を施行し長期生存を得た1例
- (株)癌と化学療法社, Nov. 2010, 癌と化学療法, 37(12) (12), 2804 - 2806, Japaneseスペーサー手術と粒子線治療による2段階治療が有効であった仙骨脊索腫の1例
- Nov. 2010, Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 107(11) (11), 1828 - 1834[Mucinous cystic neoplasm of the pancreas associated with pregnancy: report of two cases].[Refereed]
- Nov. 2010, Gan to kagaku ryoho. Cancer & chemotherapy, 37(12) (12), 2312 - 2314[A long-term survival case of postoperative lymph node metastases from hepatocellular carcinoma treated with lymph node dissection and percutaneous isolated hepatic perfusion (PIHP)].[Refereed]
- Nov. 2010, Gan to kagaku ryoho. Cancer & chemotherapy, 37(12) (12), 2804 - 2806[Particle beam radiotherapy with a surgical spacer placement for unresectable sacral chordoma].[Refereed]
- 金原出版(株), Aug. 2010, 手術, 64(9) (9), 1237 - 1242, Japanese【先端的画像支援による肝胆道手術】 3D-CT 3D-CT胆管バーチャル画像支援による肝門部胆管癌手術
- (一社)日本消化器外科学会, May 2010, 日本消化器外科学会雑誌, 43(5) (5), 548 - 553, Japanese
- 金原出版(株), May 2010, 手術, 64(6) (6), 723 - 727, Japanese【手術機器の使い方 基本と応用】 開腹手術用機器 鉗子
- Mar. 2010, Med Mol Morphol., 43(1):19-25, EnglishNovel assessment of hepatic iron distribution by synchrotron radiation X-ray fluorescence microscopy.[Refereed]Scientific journal
- Wiley-Blackwell, Jan. 2010, Journal of surgical oncology, Vol. 101, No. 1, pp. 97-9(1) (1), 97–99, English[Refereed]Scientific journal
- (公社)日本医学放射線学会, Apr. 2009, Japanese Journal of Radiology, 27(Suppl.) (Suppl.), 48 - 48, JapaneseHCCに対する粒子線治療施行後Bilomaを形成した1例
- We report a case of hemangioma with an atypical vascular enhancement pattern. The hemangioma showed peripheral rim enhancement at the arterial phase during dynamic magnetic resonance imaging, and the peripheral enhanced zone was still apparent during the delayed phase, as shown on double-phase computed tomography hepatic arteriography. The rim enhancement pattern of this case, mimicking that of hepatocellular carcinoma, may be due to the surrounding liver parenchymal fibrotic change caused by an active hepatitis C viral infection.Apr. 2009, Japanese journal of radiology, 27(3) (3), 156 - 60, English, Domestic magazine[Refereed]Scientific journal
- (株)医学書院, Mar. 2008, 肝胆膵画像, 10(2) (2), 167 - 170, Japanese
- Mar. 2006, 日本外科学会雑誌, 107巻, 臨増2, pp.704-704, Japanese脾機能亢進症に対する成人生体肝移植の意義International conference proceedings
- Mar. 2006, 日本外科学会雑誌, 107巻, 臨増2, pp.324-324, Japanese末期肝硬変患者における副腎機能の検討 肝移植後ステロイドフリー免疫抑制の是非についてInternational conference proceedings
- Mar. 2006, 日本外科学会雑誌, 107巻, 臨増2, pp.445-445, Japanese高度血管侵襲(Vp3,4)を伴う両葉多発進行肝癌に対する先端治療戦略:減量切除 経皮的肝灌流の2段階治療International conference proceedings
- Mar. 2006, 日本外科学会雑誌, 107巻, 臨増2, pp.351-351, Japanese肝右葉グラフトにおける術後肝静脈変位の解析に基づいた合理的肝静脈吻合 大伏在静脈付き大腿静脈グラフトを用いた肝静脈吻合International conference proceedings
- Mar. 2006, 日本外科学会雑誌, 107巻, 臨増2, pp.345-345, JapaneseVp3,4両葉多発肝細胞癌に対する減量切除 経皮的肝灌流による外科集学的治療の実際International conference proceedings
- Mar. 2006, 日本外科学会雑誌, 107巻, 臨増2, pp.185-185, JapaneseC型肝炎肝移植後の低用量インターフェロン・リバビリン併用療法 ウイルス血中動態とその有用性についてInternational conference proceedings
- Oct. 2005, 移植, 40巻, 総会臨時, pp.261-261, Japanese成人生体肝移植におけるドナー手術の問題点 担癌患者の肝葉切除との比較International conference proceedings
- Oct. 2005, 癌と化学療法, 32巻, 11号, pp.1815-1817, Japanese減量肝切除と経皮的肝灌流化学療法(PIHP)のDual Treatmentにより2年間の局所完全寛解を得た門脈腫瘍栓合併両葉多発肝癌の1例[Refereed]Scientific journal
- Oct. 2005, 癌と化学療法, 32巻, 11号, pp.1818-1820, Japanese減量肝切除と経皮的肝灌流(PIHP)の2段階治療(Dual Treatment)により完全に局所制御できた両側門脈腫瘍栓合併多発肝細胞癌の1例[Refereed]Scientific journal
- Oct. 2005, 移植, 40巻, 総会臨時, pp.383-383, Japanese肝内胆管癌を伴う原発性硬化性胆管炎に対して生体肝移植を施行し約1年間無再発生存を得ている一例International conference proceedings
- Oct. 2005, Gan to kagaku ryoho Cancer & chemotherapy, Vol. 32, No. 11, pp. 1815-7, English[Sustained complete remission with reductive surgery plus percutaneous isolated hepatic perfusion (PIHP) for bilobar multiple hepatocellular carcinoma with portal venous tumor thrombus--a case report]Scientific journal
- Oct. 2005, Gan to kagaku ryoho Cancer & chemotherapy, Vol. 32, No. 11, pp. 1818-20, English[A case of multiple hepatocellular carcinoma with rapidly progressing bilateral portal vein tumor thrombosis--a complete remission achieved with dual treatment of reductive surgery plus percutaneous isolated hepatic perfusion]Scientific journal
- Sep. 2005, 肝臓, 46巻, Suppl.2, pp.A425-A425, Japanese肝細胞癌リンパ節転移に対する経皮的肝灌流を併用した切除療法の意義International conference proceedings
- Aug. 2005, 外科, 67巻, 8号, pp.910-920, Japanese【遠隔転移にどのように対応するか】 原発巣からみた対応 診断と治療 肝細胞癌の遠隔転移
- Jul. 2005, 日本消化器外科学会雑誌, 38巻, 7号, pp.925-925, Japanese術後感染予防 国際的標準と我が国の現状 肝切除後のSurgical site infection(SSI)に関する米国CDCガイドラインの問題と対策International conference proceedings
- Jul. 2005, 日本消化器外科学会雑誌, 38巻, 7号, pp.1118-1118, Japanese鏡視下Hanging Maneuver法の基礎的検討International conference proceedings
- Jul. 2005, 日本消化器外科学会雑誌, 38巻, 7号, pp.1042-1042, Japanese肝細胞癌に対する生体肝移植 ミラノ基準における1cm未満の小病変の算定意義についてInternational conference proceedings
- (有)科学評論社, Jun. 2005, 消化器科, 40巻, 6号, pp.692-699(6) (6), 700 - 706, Japanese【肝癌の治療戦略】 超進行肝細胞癌に対する新世代治療戦略:減量肝切除とPIHPによるDual Treatmentは他治療をどれだけ凌駕したか?
- Apr. 2005, 日本外科学会雑誌, 106巻, 臨増, pp.215-215, Japanese生体右葉肝移植における至適肝静脈吻合法を確立するための基礎的検討 肝再生が静脈吻合に及ぼす影響についてInternational conference proceedings
- Apr. 2005, 日本外科学会雑誌, 106巻, 臨増, pp.544-544, JapaneseVp3,4両葉多発肝細胞癌(mHCC)に対するDual Tx(減量切除&経皮的肝灌流)の有効性 TAEとの比較International conference proceedings
- Dec. 2004, 移植, 39巻, 6号, pp. 689-690, Japanese門脈腫瘍栓と血栓との鑑別が術前困難であった肝細胞癌に対する成人生体肝移植の一例International conference proceedings
- Dec. 2004, 移植, 39巻, 6号, pp. 687-687, Japanese肝細胞癌高度門脈閉塞(PVO)例の生体肝移植 自家外腸骨静脈による門脈再建の工夫International conference proceedings
- Dec. 2004, 移植, 39巻, 6号, pp. 688-689, Japaneseステント留置が奏功した生体肝移植後の肝静脈-下大静脈狭窄の1例International conference proceedings
- Dec. 2004, 移植, 39巻, 6号, pp. 700-700, JapanesePTLDを発症し一旦,心停止に至った生体肝移植の一例International conference proceedings
- Dec. 2004, 外科, 66巻, 13号, pp. 1628-1633, Japanese【転移性肝癌 どこまでchallengeすべきか】 肝切除前の治療 大腸癌肝転移に対する経皮的肝灌流化学療法(PIHP)の現況
- Oct. 2004, 新薬と臨床, 53巻, 10号, pp. 1282-1282, Japanese進行肝癌(特に脈管侵襲のある症例)への取り組み 減量肝切除と経皮的肝灌流(PIHP)のDual Treatment(Dual Tx)により完全に局所制御できた両葉多発肝細胞癌の1例International conference proceedings
- Oct. 2004, 手術, 58巻, 11号, pp. 1865-1870, Japanese手術手技 肝細胞癌に対する生体肝移植術
- Aug. 2004, 移植, 39巻, 4号, pp. 473-474, Japanese生体肝移植後Steroid free免疫抑制下に発症した副腎機能不全の1例International conference proceedings
- Aug. 2004, 移植, 39巻, 4号, pp. 459-459, Japanese生体肝移植ドナーの長期予後 成人生体肝移植における右葉ドナーの長期予後International conference proceedings
- Aug. 2004, 移植, 39巻, 4号, pp. 464-464, Japanese肝移植後の原疾患の再発と対策 成人ウイルス性末期肝疾患に対する移植後の問題点 原疾患の再発とその対策を中心にInternational conference proceedings
- Aug. 2004, 消化器科, 39巻, 2号, pp. 229-235, Japanese【進行肝癌の予後改善策】 進行肝細胞癌に対する減量切除と経皮的肝灌流の併用による神戸外科戦略
- Jul. 2004, 日本消化器外科学会雑誌, 37巻, 7号, pp. 1104-1104, Japanese門脈閉塞例に対する肝葉切除の安全性評価 アシアロシンチグラムによる分肝機能解析International conference proceedings
- Jul. 2004, 日本消化器外科学会雑誌, 37巻, 7号, pp. 1200-1200, Japanese門脈血流方向からみた進行肝細胞癌における門脈腫瘍栓の発育進展速度の解析International conference proceedings
- Jul. 2004, 移植, 39巻, 総会臨時, pp. 225-225, Japanese当施設の成人生体肝移植におけるドナーの術後経過の検討International conference proceedings
- Jul. 2004, 移植, 39巻, 総会臨時, pp. 274-274, Japanese当施設における成人右葉生体肝移植の成績International conference proceedings
- Jul. 2004, 日本消化器外科学会雑誌, 37巻, 7号, pp. 1199-1199, Japanese生体肝移植後にPTLDを発症し心停止に至った一例International conference proceedings
- Jul. 2004, 移植, 39巻, 総会臨時, pp. 221-221, Japanese成人右葉生体肝移植の肝肥大が肝静脈吻合に及ぼす影響International conference proceedings
- Jul. 2004, Hepato-Gastroenterology, Vol. 51, No. 58, pp. 1183-1186, EnglishSafety of portal vein resection using centrifugal pump-assisted venous bypass between the superior mesenteric vein and the umbilical vein[Refereed]Scientific journal
- Jun. 2004, 日本外科系連合学会誌, 29巻, 3号, pp. 408-408, Japanese経皮的肝灌流を軸とした進行肝細胞癌に対する予後改善に向けた外科先端医療International conference proceedings
- Jun. 2004, 外科, 66巻, 6号, pp. 635-643, Japanese【肝切除における血管合併切除とその成績】 血管合併切除の方法と短期予後 肝細胞癌に対する門脈腫瘍栓合併肝切除
- Mar. 2004, 日本外科学会雑誌, 105巻, 臨増, pp. 251-251, Japanese高度門脈閉塞例における成人右葉生体肝移植の問題点と新たなる技術的挑戦International conference proceedings
- Mar. 2004, 日本外科学会雑誌, 105巻, 臨増, pp. 123-123, Japanese高度進行肝細胞癌の治療限界拡大への挑戦 外科切除と経皮的肝灌流(PIHP)のDual Treatmentによる新戦略International conference proceedings
- Mar. 2004, 日本外科学会雑誌, 105巻, 臨増, pp. 413-413, Japanese肝細胞癌における門脈血流方向からみた腫瘍栓の発育進展速度の解析International conference proceedings
- Mar. 2004, 日本外科学会雑誌, 105巻, 臨増, pp. 203-203, Japanese99mTc-GSAシンチグラフィーによる門脈閉塞,非閉塞葉の分肝機能解析-肝葉切除の安全性評価International conference proceedings
- Mar. 2004, 臨床外科, 59巻, 3, pp. 293-301, Japanese肝細胞癌治療の最前線:切除不能肝細胞癌に対する減量肝切除と経皮的肝灌流による集学的治療[Refereed]
- Jan. 2004, Annals Of Surgery, Vol. 239, No. 1, pp. 53-60, 53 - 60, EnglishReductive surgery plus percutaneous isolated hepatic perfusion for multiple advanced hepatocellular carcinoma[Refereed]Scientific journal
- Oct. 2003, 日本臨床外科学会雑誌, 64巻, 増刊, pp. 275-275, Japanese臨床試験におけるチーム医療 外科的新治療に関する臨床試験の問題点 高度進行肝細胞癌(HCC)に対する経皮的肝灌流(PIHP)の有効性に関する臨床第III相試験International conference proceedings
- Oct. 2003, 癌と化学療法, 30巻, 10号, pp. 1447-1451, Japanese高度進行肝細胞癌症例に対する経皮的肝灌流化学療法後の自家末梢血幹細胞採取の検討[Refereed]Scientific journal
- Oct. 2003, 肝臓, 44巻, Suppl.3, pp. A631-A631, JapaneseFDG-PETにより発見された肝細胞癌の横行結腸転移の一例International conference proceedings
- Oct. 2003, 外科, 65巻, 10号, pp. 1158-1167, Japanese【消化器疾患に対するinterventional radiology(IVR)】 肝 Interventional radiologyを活用した進行肝細胞癌に対する経皮的肝灌流化学療法
- Oct. 2003, 消化器科, 37巻, 4号, pp. 419-426, Japanese【EBMに基づいた肝細胞癌の治療】 進行多発肝細胞癌に対する減量切除と経皮的肝灌流(PIHP)の合併療法による新治療体系の確立
- Jul. 2003, 日本消化器外科学会雑誌, 36巻, 7号, pp. 892-892, Japanese残肝再生からみた成人右葉donorの潜在的risk 右葉vs中肝静脈付加右葉切除の日韓共同解析International conference proceedings
- Jul. 2003, 日本消化器外科学会雑誌, 36巻, 7号, pp. 1045-1045, Japanese酸素代謝からみた肝静脈閉塞領域における肝機能評価 静脈遮断肝灌流モデルを用いた検討International conference proceedings
- Jul. 2003, 日本消化器外科学会雑誌, 36巻, 7号, pp. 1094-1094, Japanese減量肝切除・経皮的肝灌流による完全緩解後に生体肝移植した高度進行肝細胞癌の1例International conference proceedings
- Jul. 2003, 日本消化器外科学会雑誌, 36巻, 7号, pp. 974-974, Japanese肝細胞癌リンパ節転移に対する経皮的肝灌流を併用した切除療法の意義International conference proceedings
- May 2003, Transplantation, Vol. 75, No. 9, pp. 1598-1600, EnglishSignificant role of middle hepatic vein in remnant liver regeneration of right-lobe living donors[Refereed]Scientific journal
- Apr. 2003, 日本外科学会雑誌, 104巻, 臨増, pp. 232-233, Japanese新しい肝再生促進療法の基礎的検討 G-CSFによる骨髄細胞増殖を介した肝再生の促進International conference proceedings
- Apr. 2003, 日本外科学会雑誌, 104巻, 臨増, pp. 436-436, Japanese広範な門脈血栓・末期肝不全例に対する生体肝移植 新しい後膵ルート門脈再建法International conference proceedings
- 2003, 消化器外科, 26巻, 5, pp. 587-595, Japanese高度進行肝細胞癌に対する外科修学的治療;減量切除と経皮的肝灌流によるDual TreatmentScientific journal
- 2003, Surgery Today, Vol. 33, No. 7, pp. 542-544, EnglishIsolated gastric varices resulting from iatrogenic splenic vein occlusion: report of a case[Refereed]Scientific journal
- (一社)日本癌治療学会, Oct. 2001, 日本癌治療学会誌, 36(2) (2), 351 - 351, Japanese膵癌 膵癌に対する局所化学療法の展望
- (株)南江堂, Jun. 2000, 外科, 62(6) (6), 653 - 659, Japanese【転移性肝癌治療 最近の進歩】大腸癌肝転移 Chemotherapy 抗癌剤経皮的肝灌流による大腸癌肝転移の治療
- Others, Springer, 2011, EnglishInduction Chemotherapy:Integrated Treatment Programs for Locally Advanced Cancers / Induction Chemotherapy for Hepatocellular CarcinomaScholarly book
- -, Aug. 2024, Japanese, Domestic conference-Others
- ELSA2024, Aug. 2024, English, International conferenceOptimal cutoff values of drain amylase for predicting pancreatic fistula are different between open and laparoscopic distal pancreatectomyOral presentation
- ELSA2024, Aug. 2024, English, International conferenceThe first-touch skills in robotic surgical training using a new Japanese surgical robot system and its simulatorPublic symposium
- -, Jul. 2024, Japanese, Domestic conference-Oral presentation
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- -, Jul. 2024, Japanese, Domestic conference-Public symposium
- -, Jul. 2024, Japanese, Domestic conference-Public symposium
- -, Jul. 2024, Japanese, Domestic conference-Poster presentation
- The 14th Asia-Pacific Primary Liver Cancer Expert Meeting 2026 (APPLE), Jul. 2024, English, International conferenceTextbook outcomes in initial liver resection for hepatocellular carcinoma: a study with malnutrition grade by the GLIM criteria.Poster presentation
- The 14th Asia-Pacific Primary Liver Cancer Expert Meeting 2025 (APPLE), Jul. 2024, English, International conferenceClinical significance of hepatectomy for Hepatocellular Carcinoma Associated with Lymph Node and/or Distant MetastasesPoster presentation
- The 14th Asia-Pacific Primary Liver Cancer Expert Meeting 2024 (APPLE), Jul. 2024, English, International conferenceLaparoscopic Liver Resection after PancreaticoduodenectomyPoster presentation
- -, Jul. 2024, Japanese, Domestic conference-Oral presentation
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- -, Jul. 2024, Japanese, Domestic conference-Others
- -, Jun. 2024, English, Domestic conferenceComparison of laparoscopic partial liver resection for the superior and the inferior areas of segment 4Oral presentation
- -, Jun. 2024, English, Domestic conferenceEfficacy of the bile leak test using contrast-enhanced intraoperative ultrasonic cholangiography in liver resection: A prospective studyOral presentation
- -, Jun. 2024, English, Domestic conferenceShort- and long-term outcomes after pancreatectomy for pancreatic cancer in octogenarianPublic symposium
- -, Jun. 2024, English, Domestic conferenceA Novel Navigation Technology for Liver Surgery Using Spectral ImagingOral presentation
- -, Jun. 2024, English, Domestic conferenceOur Surgical Techniques for Pancreatic Cancer with Arterial ContactOral presentation
- -, Jun. 2024, English, Domestic conferenceNightmare for a 16-year-old man who presented with undiagnosed severe diabetes-induced NOMI and required a total pancreatectomy and massive enterectomyOral presentation
- -, Jun. 2024, English, Domestic conferenceClinical significance of hepatectomy for hepatocellular carcinoma associated with lymph node and/ or distant metastasesPublic symposium
- -, Jun. 2024, English, Domestic conferenceTreatment outcomes of hepatectomy and systemic chemotherapy based on the oncological criteria of resectabilityPublic symposium
- -, Jun. 2024, English, Domestic conference-Others
- -, Jun. 2024, Japanese, Domestic conference-Others
- -, Jun. 2024, Japanese, Domestic conference-
- Computer Assisted Radiology and Surgery 38th International Congress and Exhibition(CARS2024 ), Jun. 2024, English, International conference-
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- -, Apr. 2024, Japanese, Domestic conference-Poster presentation
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- -, Apr. 2024, Japanese, Domestic conference-Public symposium
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- SAGES 2024, Apr. 2024, Japanese, International conference-Poster presentation
- -, Apr. 2024, Japanese, Domestic conference-Public symposium
- -, Apr. 2024, Japanese, Domestic conference-Others
- The 33rd Annual Meeting the Asian Pacific Association for the Study of the Liver (APASL2024), Mar. 2024, English, International conference-Poster presentation
- The 33rd Annual Meeting the Asian Pacific Association for the Study of the Liver (APASL2024), Mar. 2024, English, International conference-Poster presentation
- The 33rd Annual Meeting the Asian Pacific Association for the Study of the Liver (APASL2024), Mar. 2024, English, International conference-Poster presentation
- The 33rd Annual Meeting the Asian Pacific Association for the Study of the Liver (APASL2024), Mar. 2024, English, International conference-Oral presentation
- The 33rd Annual Meeting the Asian Pacific Association for the Study of the Liver (APASL2024), Mar. 2024, English, International conference-Oral presentation
- The 33rd Annual Meeting the Asian Pacific Association for the Study of the Liver (APASL2024), Mar. 2024, English, International conference-Oral presentation
- The 33rd Annual Meeting the Asian Pacific Association for the Study of the Liver (APASL2024), Mar. 2024, English, International conference-Oral presentation
- -, Mar. 2024, Japanese, Domestic conference-Others
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- -, Feb. 2024, Japanese, Domestic conference-Public discourse
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- -, Dec. 2023, Japanese, Domestic conference-Others
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- -, Dec. 2023, Japanese-Public symposium
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- -, Oct. 2023, Japanese, Domestic conference-Others
- 7th Kansai-Yeungnam HBP Surgeons Meeting, Oct. 2023, English, International conferenceProton radiotherapy as a treatment strategy to increase survival in locally advanced pancreatic cancer in the body and tail: a retrospective studyPoster presentation
- 7th Kansai-Yeungnam HBP Surgeons Meeting, Oct. 2023, English, International conferenceRisk Factors for Recurrence of Cholangitis After Pancreaticoduodenectomy and Comparison of Stents in HepaticojejunostomyPoster presentation
- -, Oct. 2023, Japanese, Domestic conference-Oral presentation
- -, Sep. 2023, Japanese, Domestic conference-Others
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- -, Jul. 2023, Japanese, Domestic conference-Oral presentation
- -, Jul. 2023, Japanese, Domestic conference-Oral presentation
- -, Jul. 2023, Japanese, Domestic conference-Oral presentation
- -, Jul. 2023, Japanese, Domestic conference-Oral presentation
- -, Jul. 2023, Japanese, Domestic conference-Oral presentation
- -, Jul. 2023, Japanese, Domestic conference-Oral presentation
- -, Jul. 2023, Japanese, Domestic conference-Oral presentation
- -, Jul. 2023, Japanese, Domestic conference-Oral presentation
- -, Jul. 2023, Japanese, Domestic conference-Oral presentation
- -, Jul. 2023, Japanese, Domestic conference-Oral presentation
- -, Jul. 2023, Japanese, Domestic conference-Oral presentation
- -, Jul. 2023, Japanese, Domestic conference-Oral presentation
- -, Jul. 2023, Japanese, Domestic conference-Oral presentation
- -, Jul. 2023, Japanese, Domestic conference-Oral presentation
- -, Jul. 2023, Japanese, Domestic conference-Oral presentation
- -, Jul. 2023, Japanese, Domestic conference-Oral presentation
- -, Jul. 2023, Japanese, Domestic conference-Oral presentation
- -, Jul. 2023, Japanese, Domestic conference-Oral presentation
- -, Jul. 2023, Japanese, Domestic conference-Oral presentation
- -, Jul. 2023, Japanese, Domestic conference-Oral presentation
- -, Jul. 2023, Japanese, Domestic conference-Oral presentation
- -, Jul. 2023, Japanese, Domestic conference-Oral presentation
- -, Jul. 2023, Japanese, Domestic conference-Oral presentation
- -, Jul. 2023, Japanese, Domestic conference-Public symposium
- -, Jul. 2023, Japanese, Domestic conference-Public symposium
- -, Jul. 2023, Japanese, Domestic conference-Public symposium
- -, Jul. 2023, Japanese, Domestic conference-Others
- -, Jul. 2023, English, International conference-Others
- -, Jun. 2023, English, Domestic conference-Poster presentation
- -, Jun. 2023, English, Domestic conference-Poster presentation
- -, Jun. 2023, English, Domestic conference-Poster presentation
- -, Jun. 2023, English, Domestic conference-Poster presentation
- -, Jun. 2023, English, Domestic conference-Oral presentation
- -, Jun. 2023, English, Domestic conference-Oral presentation
- -, Jun. 2023, English, Domestic conference-Oral presentation
- -, Jun. 2023, English, Domestic conference-Oral presentation
- -, Jun. 2023, English, Domestic conference-Public symposium
- -, Jun. 2023, English, Domestic conference-Public symposium
- -, Jun. 2023, English, Domestic conference-Public symposium
- -, Jun. 2023, English, Domestic conference-Public symposium
- -, Jun. 2023, English, Domestic conference-Others
- -, Jun. 2023, English, International conference-Poster presentation
- -, Jun. 2023, English, International conference-Oral presentation
- -, Jun. 2023, Japanese, Domestic conference-Oral presentation
- -, Jun. 2023, Japanese, Domestic conference-Oral presentation
- -, Jun. 2023, Japanese, Domestic conference-Oral presentation
- -, Jun. 2023, Japanese, Domestic conference-Public symposium
- -, Jun. 2023, Japanese, Domestic conference-Public symposium
- -, Jun. 2023, Japanese, Domestic conference-Public symposium
- -, Jun. 2023, Japanese, Domestic conference-Others
- -, Jun. 2023, Japanese, Domestic conference-Oral presentation
- -, Jun. 2023, Japanese, Domestic conference-Others
- -, Jun. 2023, Japanese, Domestic conference-Others
- -, Jun. 2023, Japanese, Domestic conference-Oral presentation
- -, Jun. 2023, Japanese, Domestic conference-Invited oral presentation
- -, Jun. 2023, Japanese, Domestic conference-Public symposium
- -, Jun. 2023, Japanese, Domestic conference-Public symposium
- -, Jun. 2023, Japanese, Domestic conference-Others
- -, May 2023, Japanese, Domestic conference-Others
- -, May 2023, Japanese, Domestic conference-Oral presentation
- -, May 2023, Japanese, Domestic conference-Oral presentation
- -, May 2023, Japanese, Domestic conference-Oral presentation
- -, May 2023, Japanese, International conference-Oral presentation
- -, May 2023, Japanese, International conference-Public symposium
- -, May 2023, Japanese, International conference-Others
- -, May 2023, English, International conferenceThe factors of predicting over-time weight increase after liver transplantationPoster presentation
- -, May 2023, English, International conferenceIndication of liver transplantation in the treatment of newly categorized acute-on-chronic liver failure in JapanPoster presentation
- -, Apr. 2023, Japanese, Domestic conference-Poster presentation
- -, Apr. 2023, Japanese, Domestic conference-Poster presentation
- -, Apr. 2023, Japanese, Domestic conference-Poster presentation
- -, Apr. 2023, Japanese, Domestic conference-Poster presentation
- -, Apr. 2023, Japanese, Domestic conference-Poster presentation
- -, Apr. 2023, Japanese, Domestic conference-Poster presentation
- -, Apr. 2023, Japanese, Domestic conference-Poster presentation
- -, Apr. 2023, Japanese, International conference-Poster presentation
- -, Apr. 2023, Japanese, Domestic conference-Poster presentation
- -, Apr. 2023, Japanese, Domestic conference-Poster presentation
- -, Apr. 2023, Japanese, Domestic conference-Poster presentation
- -, Apr. 2023, Japanese, Domestic conference-Poster presentation
- -, Apr. 2023, Japanese, Domestic conference-Poster presentation
- -, Apr. 2023, Japanese, Domestic conference-Poster presentation
- -, Apr. 2023, Japanese, Domestic conference-Poster presentation
- -, Apr. 2023, Japanese, Domestic conference-Poster presentation
- -, Apr. 2023, Japanese, Domestic conference-Poster presentation
- -, Apr. 2023, Japanese, Domestic conference-Oral presentation
- -, Apr. 2023, Japanese, Domestic conference-Invited oral presentation
- -, Apr. 2023, Japanese, Domestic conference-Invited oral presentation
- -, Apr. 2023, Japanese, Domestic conference-Public symposium
- -, Apr. 2023, Japanese, Domestic conference-Public symposium
- -, Apr. 2023, Japanese, Domestic conference-Public symposium
- -, Apr. 2023, Japanese, Domestic conference-Public symposium
- -, Apr. 2023, Japanese, Domestic conference-Public symposium
- -, Apr. 2023, Japanese, Domestic conference-Others
- -, Apr. 2023, Japanese, Domestic conference-Others
- -, Apr. 2023, Japanese, International conference-Others
- -, Apr. 2023, Japanese, Domestic conference-Others
- -, Apr. 2023, Japanese, Domestic conference-Oral presentation
- -, Apr. 2023, Japanese, Domestic conference-Oral presentation
- -, Apr. 2023, Japanese, Domestic conference-Oral presentation
- -, Apr. 2023, Japanese, Domestic conference-Oral presentation
- -, Apr. 2023, Japanese, Domestic conference-Oral presentation
- -, Apr. 2023, Japanese, International conference-Public symposium
- -, Apr. 2023, Japanese, Domestic conference-Public symposium
- -, Apr. 2023, Japanese, Domestic conference-Public symposium
- -, Apr. 2023, Japanese, Domestic conference-Public symposium
- -, Mar. 2023, Japanese, Domestic conference-Others
- -, Mar. 2023, Japanese, Domestic conference-Others
- -, Mar. 2023, Japanese, Domestic conference-Oral presentation
- -, Mar. 2023, Japanese, International conference-Oral presentation
- -, Mar. 2023, Japanese, International conference-Public symposium
- -, Mar. 2023, Japanese, Domestic conference-Public symposium
- -, Mar. 2023, Japanese, International conference-Others
- -, Mar. 2023, Japanese, Domestic conference-Oral presentation
- -, Feb. 2023, Japanese, Domestic conference-Public symposium
- -, Jan. 2023, Japanese, Domestic conference-Others
- -, Jan. 2023, Japanese, Domestic conference-Oral presentation
- -, Jan. 2023, Japanese, Domestic conference-Others
- -, Jan. 2023, Japanese, Domestic conference-Others
- 第39回近畿肝移植検討会, Dec. 2022, Japanese, Domestic conference脳死肝移植登録待機中管理に難渋した一例Others
- 第39回近畿肝移植検討会, Dec. 2022, Japanese, Domestic conference閉会の辞Others
- 第39回近畿肝移植検討会, Dec. 2022, Japanese, Domestic conference座長(特別講演2)Others
- Asian-Pacific Congress of Robotic Laparoscopic Surgery 2022 (ACRLS 2022), Dec. 2022, English, International conferenceLaparoscopic anatomical resection of segment 2 by Glissonean approachOral presentation
- 第35回日本内視鏡外科学会総会, Dec. 2022, Japanese, Domestic conference当院における腹腔鏡下膵頭十二指腸切除の導入Oral presentation
- 第35回日本内視鏡外科学会総会, Dec. 2022, Japanese, Domestic conferenceロボット支援膵切除時代における技術認定制度の役割と問題点Public symposium
- 第35回日本内視鏡外科学会総会, Dec. 2022, Japanese, Domestic conference当施設での亜区域切除のアプローチ法Public symposium
- 医学研究科医療創成工学専攻紹介シンポジウム, Nov. 2022, Japanese, Domestic conferenceまとめと挨拶Others
- Transplantation Science Symposium(TSS) Asian Regional Meeting 2022, Nov. 2022, English, International conferenceThe Factors of Predicting Over-Time Weight Increase After Liver TransplantationOral presentation
- Transplantation Science Symposium(TSS) Asian Regional Meeting 2022, Nov. 2022, English, International conferenceChair(Mini Oral 41)Others
- 第44回日本肝臓学会東部会, Nov. 2022, Japanese, Domestic conference粒子線治療適応拡大を可能とする新規素材吸収性スペーサーの開発と臨床応用した肝細胞癌の 1 例Oral presentation
- 第44回日本肝臓学会東部会, Nov. 2022, Japanese, Domestic conference肝 S8 領域に生じた肝細胞癌に対する腹腔鏡下肝切除術の有効性に関する検討Oral presentation
- 第44回日本肝臓学会東部会, Nov. 2022, Japanese, Domestic conference初回再発形式からみる肝細胞癌の腫瘍位置と初回再発形式に関する検討Oral presentation
- 第44回日本肝臓学会東部会, Nov. 2022, Japanese, Domestic conference肝疾患患者における呼吸アンモニア濃度の測定Public symposium
- 医療機器創出のための地域連携促進シンポジウム, Nov. 2022, Japanese, Domestic conference挨拶Others
- 医療機器創出のための地域連携促進シンポジウム, Nov. 2022, Japanese, Domestic conference座長(第2部)Others
- 第16回肝臓内視鏡外科研究会, Nov. 2022, Japanese, Domestic conference腹腔鏡下肝亜区域切除で最も厄介な S7 領域Public symposium
- 第14回膵臓内視鏡外科研究会, Nov. 2022, Japanese, Domestic conferenceロボット支援下膵体尾部切除導入期に直面する諸問題Public symposium
- 第14回膵臓内視鏡外科研究会, Nov. 2022, Japanese, Domestic conference門脈輪状膵を併存した症例に対する腹腔鏡下膵切除術の経験Oral presentation
- 第14回膵臓内視鏡外科研究会, Nov. 2022, Japanese, Domestic conference腹腔鏡下膵体尾切除術の膵頚部切離における 45mm カートリッジの有用性Public symposium
- 第25回 近畿膵移植検討会, Nov. 2022, Japanese, Domestic conference司会(特別講演)Invited oral presentation
- 第25回 近畿膵移植検討会, Nov. 2022, Japanese, Domestic conference開会挨拶Others
- 第35回日本外科感染症学会総会学術集会, Nov. 2022, Japanese, Domestic conference胆道癌に対する術前胆汁返還の SSI に対する意義Public symposium
- 第19回神戸消化器外科懇話会学術講演会, Nov. 2022, Japanese, Domestic conference座長(特別講演Ⅱ)Others
- JDDDW2022, Oct. 2022, English, Domestic conferenceThe usefulness of total tumor volume as a prognostic factor with colorectal cancer liver metastasesPoster presentation
- 第20回消化器外科学会大会(JDDW2022), Oct. 2022, Japanese, Domestic conference肝S8病変に対する腹腔鏡下肝切除術適応の有効性Poster presentation
- 第20回消化器外科学会大会(JDDW2022), Oct. 2022, Japanese, Domestic conference肝切除後の術後静脈血栓塞栓症の発症における予測スコアの有用性の検討Poster presentation
- 第20回消化器外科学会大会(JDDW2022), Oct. 2022, Japanese, Domestic conference当科における非吸収性スペーサー留置術の成績と今後の課題Poster presentation
- 第20回消化器外科学会大会(JDDW2022), Oct. 2022, Japanese, Domestic conference膵頭十二指腸切除術後の早期胆管炎リスク因子の検討Poster presentation
- 第20回消化器外科学会大会(JDDW2022), Oct. 2022, Japanese, Domestic conference再発形式からみる表在性肝細胞癌に対する非解剖学的切除術の妥当性の検討Poster presentation
- 第20回消化器外科学会大会(JDDW2022), Oct. 2022, Japanese, Domestic conference初発単発肝細胞癌に対する肝切除と粒子線治療成績の比較検討Poster presentation
- 第20回消化器外科学会大会(JDDW2022), Oct. 2022, Japanese, Domestic conference胆嚢癌におけるInflammation-based prognostic scoresの予後への影響Poster presentation
- 第20回消化器外科学会大会(JDDW2022), Oct. 2022, Japanese, Domestic conference局所進行切除不能膵癌に対する粒子線治療の成績とスペーサー留置術の有用性についてPoster presentation
- 第20回消化器外科学会大会(JDDW2022), Oct. 2022, Japanese, Domestic conference血清D-dimer値を用いた膵切除後静脈血栓症予測Poster presentation
- 第20回消化器外科学会大会(JDDW2022), Oct. 2022, Japanese, Domestic conference食道癌術後の膵癌に対する膵切除6例の検討Poster presentation
- 第20回消化器外科学会大会(JDDW2022), Oct. 2022, Japanese, Domestic conference肝動脈化学塞栓療法を中心とした膵神経内分泌腫瘍肝転移に対する集学的治療Poster presentation
- 第20回消化器外科学会大会(JDDW2022), Oct. 2022, Japanese, Domestic conference肝細胞癌に対するmajor hepatectomy後の術後肝不全発症早期予測における術後1日目CRP低値の有用性Poster presentation
- 第20回消化器外科学会大会(JDDW2022), Oct. 2022, Japanese, Domestic conference肝S7切除における腹腔鏡手術と開腹手術の手術成績の比較Poster presentation
- 第20回消化器外科学会大会(JDDW2022), Oct. 2022, Japanese, Domestic conference胆管癌の術後早期再発症例の検討Poster presentation
- 第20回消化器外科学会大会(JDDW2022), Oct. 2022, Japanese, Domestic conference-Poster presentation
- 第20回消化器外科学会大会(JDDW2022), Oct. 2022, Japanese, Domestic conference非乳頭部十二指腸癌に対する手術成績Poster presentation
- 第20回消化器外科学会大会(JDDW2022), Oct. 2022, Japanese, Domestic conference腹腔鏡下膵体尾部切除における45mmカートリッジを用いた膵切離Poster presentation
- 第20回消化器外科学会大会(JDDW2022), Oct. 2022, Japanese, Domestic conference進行胆道癌に対する集学的治療の役割Public symposium
- 第20回消化器外科学会大会(JDDW2022), Oct. 2022, Japanese, Domestic conference司会(ブレックファーストセミナー33)Others
- 第64回消化器病学会大会(JDDW2022), Oct. 2022, Japanese, Domestic conferenceIntermediate HCCに対する集学的アプローチPoster presentation
- 第26回肝臓学会大会(JDDW2022), Oct. 2022, Japanese, Domestic conferenceポストコロナ時代における急性肝不全に対する移植医療Poster presentation
- 第26回肝臓学会大会(JDDW2022), Oct. 2022, Japanese, Domestic conference司会(ポスターセッション 肝031)Others
- 第60回癌治療学会学術集会, Oct. 2022, Japanese, Domestic conference膵・胆道癌の腹腔洗浄細胞診における、剥離細胞分析装置 LC-1000 の有用性に関する研究Oral presentation
- 第60回癌治療学会学術集会, Oct. 2022, Japanese, Domestic conference-Oral presentation
- 第58回日本移植学会総会, Oct. 2022, Japanese, Domestic conference移植後非結核性抗酸菌症治療中にCOVID-19を発症した一例Oral presentation
- 第58回日本移植学会総会, Oct. 2022, Japanese, Domestic conferenceコロナ禍における肝移植医療の現状と課題Oral presentation
- 第58回日本移植学会総会, Oct. 2022, Japanese, Domestic conference移植医療における働き方改革推進の現状と課題Oral presentation
- 第58回日本移植学会総会, Oct. 2022, Japanese, Domestic conference司会(臓器横断的シンポジウム5)Others
- 第58回日本胆道学会学術集会, Oct. 2022, Japanese, Domestic conference胆管非拡張型膵・胆管合流異常に対する胆嚢摘出後胆管径の推移についてOral presentation
- 第58回日本胆道学会学術集会, Oct. 2022, Japanese, Domestic conference進行胆道癌における化学療法の現状と限界Public symposium
- 第7回神戸肝胆膵外科ビデオクリニック, Oct. 2022, Japanese, Domestic conference開会挨拶Others
- 第23回神戸外科フォーラム, Oct. 2022, Japanese, Domestic conference座長(特別講演Ⅰ)Others
- 第23回神戸外科フォーラム, Sep. 2022, Japanese, Domestic conference開会の挨拶Others
- 近畿内視鏡外科研究会第35回大会, Sep. 2022, Japanese, Domestic conference-Others
- 日本蛍光ガイド手術研究会第5回学術集会, Sep. 2022, Japanese, Domestic conferenceICG蛍光法を用いた腹腔鏡下肝S2亜区域切除術Public symposium
- Conversion Surgery Meeting in KOBE, Sep. 2022, Japanese, Domestic conference総合司会Others
- 第45回日本膵・胆管合流異常研究会, Sep. 2022, Japanese, Domestic conference胆管非拡張型膵・胆管合流異常に対する胆嚢摘出後の胆管径の変化に関する検討(第2報)Invited oral presentation
- APASL Oncology 2022, Sep. 2022, English, International conferenceHepatic Resection versus Particle Therapy for Single Hepatocellular Carcinoma as An Initial Treatment: A Multicenter Propensity Score Matched AnalysisPoster presentation
- 第56回近畿肝癌談話会, Aug. 2022, Japanese, Domestic conference進行肝細胞癌における Conversion surgery の妥当性Oral presentation
- 第56回近畿肝癌談話会, Aug. 2022, Japanese, Domestic conference会長(会長挨拶)Others
- 第77回日本消化器外科学会総会, Jul. 2022, JapaneseOur surgical technique of vascular resection for locally advanced pancreatic cancerPublic symposium
- 第77回日本消化器外科学会総会, Jul. 2022, JapaneseMultidisciplinary approach for advanced hepatocellular carcinomaPublic symposium
- 第77回日本消化器外科学会総会, Jul. 2022, JapanesePreoperative HbA1c and transthyretin concentrations predict survival after total pancreatectomyPublic symposium
- -, Jul. 2022, Japanese, Domestic conferenceーOral presentation
- -, Jul. 2022, Japanese, Domestic conferenceーOral presentation
- -, Jul. 2022, Japanese, Domestic conferenceーOral presentation
- -, Jul. 2022, Japanese, Domestic conferenceーOral presentation
- -, Jul. 2022, Japanese, Domestic conferenceーOral presentation
- -, Jul. 2022, Japanese, Domestic conferenceーOral presentation
- -, Jul. 2022, Japanese, Domestic conferenceーOral presentation
- -, Jul. 2022, Japanese, Domestic conferenceーOral presentation
- -, Jul. 2022, Japanese, Domestic conferenceーOral presentation
- -, Jul. 2022, Japanese, Domestic conferenceーOral presentation
- -, Jul. 2022, Japanese, Domestic conferenceーOral presentation
- -, Jul. 2022, Japanese, Domestic conferenceーOral presentation
- -, Jul. 2022, Japanese, Domestic conferenceーOral presentation
- -, Jul. 2022, Japanese, Domestic conferenceーOral presentation
- -, Jul. 2022, Japanese, Domestic conferenceーOral presentation
- -, Jul. 2022, Japanese, Domestic conferenceーOral presentation
- -, Jul. 2022, Japanese, Domestic conferenceーOral presentation
- -, Jul. 2022, Japanese, Domestic conferenceーOral presentation
- -, Jul. 2022, Japanese, Domestic conferenceーInvited oral presentation
- -, Jul. 2022, Japanese, Domestic conferenceーPublic symposium
- -, Jul. 2022, Japanese, Domestic conferenceーOthers
- -, Jul. 2022, Japanese, Domestic conferenceーOthers
- -, Jul. 2022, Japanese, Domestic conferenceーOthers
- -, Jul. 2022, Japanese, Domestic conferenceーOral presentation
- -, Jul. 2022, Japanese, Domestic conferenceーOral presentation
- -, Jul. 2022, Japanese, Domestic conferenceーOral presentation
- -, Jul. 2022, Japanese, Domestic conferenceーOthers
- -, Jul. 2022, Japanese, Domestic conferenceーPublic symposium
- EAES2022, Jul. 2022, EnglishStandardization of laparoscopic anatomic liver resection of segment 2 by glissonean approachPoster presentation
- -, Jul. 2022, Japanese, Domestic conferenceーOthers
- -, Jun. 2022, Japanese, Domestic conferenceーInvited oral presentation
- -, Jun. 2022, Japanese, Domestic conferenceーPublic symposium
- -, Jun. 2022, Japanese, Domestic conferenceーOral presentation
- -, Jun. 2022, Japanese, Domestic conferenceーOral presentation
- -, Jun. 2022, Japanese, Domestic conferenceーInvited oral presentation
- -, Jun. 2022, Japanese, Domestic conferenceーPublic symposium
- -, Jun. 2022, English, Domestic conferenceImpact of Delayed Gastric Emptying After Pancreatoduodenectomy on Postoperative Nutritional StatusOthers
- -, Jun. 2022, English, Domestic conferenceSpontaneous rupture of splenic hilar lymph node metastasis from hepatocellular carcinoma: a rare case reportOthers
- -, Jun. 2022, English, Domestic conferenceRisk factors of refractory cholangitis after pancreaticoduodenectomyOthers
- -, Jun. 2022, English, Domestic conferenceLaparoscopic anatomic liver resection of segment 2 based on the anatomical variation of the hepatic veinsOthers
- -, Jun. 2022, English, Domestic conferenceLow levels of C-reactive protein on postoperative day 1 are an early predictor for posthepatectomy liver failure in hepatocellular carcinoma patients undergoing right hepatectomyOthers
- -, Jun. 2022, English, Domestic conferenceCurrent role of atezolizumab plus bevacizumab therapy in the sequential treatment of unresectable hepatocellular carcinomaOthers
- -, Jun. 2022, English, Domestic conferenceUtility of plasma serum D-dimer for diagnosis of venous thromboembolism after hepatectomyOthers
- -, Jun. 2022, English, Domestic conferenceEfficacy analyses of neoadjuvant treatment for patients with “resectable” pancreatic ductal adenocarcinomaOthers
- -, Jun. 2022, English, Domestic conferenceLaparoscopic Spleen Preserving Distal Pancreatectomy with Splenic Vessels PreservationOthers
- -, Jun. 2022, English, Domestic conferenceThe usefulness of total tumor volume as a prognostic factor in patients with colorectal cancer liver metastasesPublic symposium
- -, Jun. 2022, English, Domestic conferenceMultidisciplinary approach for advanced hepatocellular carcinomaPublic symposium
- -, Jun. 2022, English, Domestic conferenceーOthers
- -, Jun. 2022, Japanese, Domestic conferenceーOral presentation
- -, Jun. 2022, Japanese, Domestic conferenceーPoster presentation
- -, Jun. 2022, Japanese, Domestic conferenceーOral presentation
- -, Jun. 2022, Japanese, Domestic conferenceーOral presentation
- -, Jun. 2022, Japanese, Domestic conferenceーOral presentation
- -, Jun. 2022, Japanese, Domestic conferenceーPublic symposium
- -, May 2022, Japanese, Domestic conferenceーOthers
- -, May 2022, Japanese, Domestic conferenceーOral presentation
- -, May 2022, Japanese, Domestic conferenceーOthers
- -, May 2022, Japanese, Domestic conference-Others
- -, May 2022, Japanese, Domestic conference-Oral presentation
- -, May 2022, Japanese, Domestic conference-Others
- 第108回日本消化器病学会総会, Apr. 2022, Japanese高度進行肝細胞癌に対する集学的アプローチOral presentation
- 第108回日本消化器病学会総会, Apr. 2022, Japanese-Oral presentation
- -, Apr. 2022, Japanese, Domestic conference-Oral presentation
- -, Apr. 2022, Japanese, Domestic conference-Public symposium
- -, Apr. 2022, Japanese, Domestic conference-Public symposium
- -, Apr. 2022, Japanese-Oral presentation
- -, Apr. 2022, Japanese, Domestic conference-Public symposium
- -, Apr. 2022, Japanese, Domestic conference-Poster presentation
- -, Apr. 2022, Japanese, Domestic conference-Poster presentation
- -, Apr. 2022, Japanese, Domestic conference-Poster presentation
- -, Apr. 2022, Japanese, Domestic conference-Poster presentation
- -, Apr. 2022, Japanese, Domestic conference-Poster presentation
- -, Apr. 2022, Japanese, Domestic conference-Poster presentation
- -, Apr. 2022, Japanese, Domestic conference-Poster presentation
- -, Apr. 2022, Japanese, Domestic conference-Poster presentation
- -, Apr. 2022, Japanese, Domestic conference-Poster presentation
- -, Apr. 2022, Japanese, Domestic conference-Poster presentation
- -, Apr. 2022, Japanese, Domestic conference-Poster presentation
- -, Apr. 2022, Japanese, Domestic conference-Oral presentation
- -, Apr. 2022, Japanese, Domestic conference-Oral presentation
- -, Apr. 2022, Japanese, Domestic conference-Oral presentation
- -, Apr. 2022, Japanese, Domestic conference-Oral presentation
- -, Apr. 2022, Japanese, Domestic conference-Oral presentation
- -, Apr. 2022, Japanese, Domestic conference-Oral presentation
- -, Apr. 2022, Japanese, Domestic conference-Oral presentation
- -, Apr. 2022, Japanese, Domestic conference-Others
- 15th World Congress of the International Hepato-Pancreato-Biliary Association (IHPBA), Mar. 2022, English, Domestic conferenceIntraoperative Assessment of the Demarcation Line and Intersegmental/Sectional Planes in Liver SurgeryPoster presentation
- -, Mar. 2022, Japanese, Domestic conference-Oral presentation
- -, Mar. 2022, Japanese, Domestic conference-Others
- -, Mar. 2022, Japanese, Domestic conference-Oral presentation
- -, Mar. 2022, Japanese, Domestic conference-Public symposium
- SAGES 2022 Annual Meeting, Mar. 2022, English, Domestic conferenceLaparoscopic anatomic liver resection if segment 2 by glissonean approachPoster presentation
- -, Mar. 2022, Japanese, International conference-Oral presentation
- -, Mar. 2022, Japanese, International conference-Public symposium
- -, Feb. 2022, Japanese, Domestic conference-Oral presentation
- ー, Dec. 2021, Japanese, Domestic conference-Oral presentation
- ー, Dec. 2021, Japanese, Domestic conference-Oral presentation
- ー, Dec. 2021, Japanese, Domestic conference-Oral presentation
- ー, Dec. 2021, Japanese, Domestic conference-Oral presentation
- ー, Dec. 2021, Japanese, Domestic conference-Oral presentation
- ー, Dec. 2021, Japanese, Domestic conference-Others
- ー, Dec. 2021, Japanese, Domestic conference-Oral presentation
- ー, Dec. 2021, Japanese, Domestic conference-Oral presentation
- ー, Dec. 2021, Japanese, Domestic conference-Public symposium
- ー, Dec. 2021, Japanese, Domestic conference-Oral presentation
- 日本泌尿器科学会総会, Dec. 2021, Japanese, (一社)日本泌尿器科学会総会事務局生体分解性亜鉛マグネシウム合金の開発及び、尿路手術での使用の検討
- ー, Nov. 2021, Japanese, Domestic conference-Others
- ー, Nov. 2021, Japanese, Domestic conference-Oral presentation
- ー, Nov. 2021, Japanese, Domestic conference-Public symposium
- ー, Nov. 2021, Japanese, Domestic conference-Public symposium
- ー, Nov. 2021, Japanese, Domestic conference-Oral presentation
- -, Nov. 2021, Japanese, Domestic conference-Poster presentation
- -, Nov. 2021, Japanese, Domestic conference-Poster presentation
- -, Nov. 2021, Japanese, Domestic conference-Poster presentation
- -, Nov. 2021, Japanese, Domestic conference-Poster presentation
- -, Nov. 2021, Japanese, Domestic conference-Poster presentation
- -, Nov. 2021, Japanese, Domestic conference-Public symposium
- -, Nov. 2021, Japanese, Domestic conference-Poster presentation
- -, Nov. 2021, Japanese, Domestic conference-Poster presentation
- -, Nov. 2021, Japanese, Domestic conference-Public symposium
- -, Nov. 2021, Japanese, Domestic conference-Poster presentation
- -, Nov. 2021, Japanese, Domestic conference-Others
- -, Nov. 2021, Japanese, Domestic conference-Nominated symposium
- -, Nov. 2021, Japanese, Domestic conference-Others
- 日本生化学会大会プログラム・講演要旨集, Nov. 2021, Japanese, (公社)日本生化学会Wnt標的遺伝子GREB1の組織特異的発現制御と肝細胞がんの増殖制御機構
- 日本生化学会大会プログラム・講演要旨集, Nov. 2021, Japanese, (公社)日本生化学会DKK1-CKAP4シグナルは肝癌の予後不良因子であり、CKAP4は新たな治療標的となりうる
- -, Oct. 2021, Japanese, Domestic conference-Public symposium
- -, Oct. 2021, Japanese, Domestic conference-Public discourse
- -, Oct. 2021, Japanese, Domestic conference-Others
- -, Oct. 2021, Japanese, Domestic conference-Others
- -, Oct. 2021, Japanese, Domestic conference-Others
- -, Sep. 2021, Japanese, Domestic conference-Poster presentation
- -, Sep. 2021, Japanese, Domestic conference-Others
- -, Sep. 2021, Japanese, Domestic conference-Others
- -, Sep. 2021, Japanese, Domestic conference-Public symposium
- -, Sep. 2021, Japanese, Domestic conference-Public symposium
- -, Sep. 2021, Japanese, Domestic conference-Public symposium
- -, Sep. 2021, Japanese, Domestic conference-Oral presentation
- -, Sep. 2021, Japanese, Domestic conference-Public symposium
- -, Sep. 2021, Japanese, Domestic conference-Others
- -, Sep. 2021, Japanese, Domestic conference-Oral presentation
- -, Sep. 2021, Japanese, Domestic conference-Others
- -, Jul. 2021, Japanese, Domestic conference-Oral presentation
- -, Jul. 2021, Japanese, Domestic conference-Oral presentation
- -, Jul. 2021, Japanese, Domestic conference-Oral presentation
- -, Jul. 2021, Japanese, Domestic conference-Oral presentation
- -, Jul. 2021, Japanese, Domestic conference-Oral presentation
- -, Jul. 2021, Japanese, Domestic conference-Others
- -, Jul. 2021, Japanese, Domestic conference-Oral presentation
- -, Jul. 2021, Japanese, Domestic conference-Oral presentation
- -, Jul. 2021, Japanese, Domestic conference-Oral presentation
- -, Jul. 2021, Japanese, Domestic conference-Oral presentation
- -, Jul. 2021, Japanese, Domestic conference-Oral presentation
- -, Jul. 2021, Japanese, Domestic conference-Invited oral presentation
- -, Jul. 2021, Japanese, Domestic conference-Oral presentation
- -, Jul. 2021, Japanese, Domestic conference-Invited oral presentation
- -, Jul. 2021, Japanese, Domestic conference-Oral presentation
- -, Jul. 2021, Japanese, Domestic conference-Oral presentation
- -, Jul. 2021, Japanese, Domestic conference-Invited oral presentation
- -, Jul. 2021, Japanese, Domestic conference-Oral presentation
- -, Jul. 2021, Japanese, Domestic conference-Oral presentation
- -, Jul. 2021, Japanese, Domestic conference-Others
- -, Jun. 2021, Japanese, Domestic conference-Others
- -, Jun. 2021, Japanese, Domestic conference-Oral presentation
- -, Jun. 2021, Japanese, Domestic conference-Public symposium
- -, Jun. 2021, Japanese, Domestic conference-Others
- -, Jun. 2021, Japanese, Domestic conference-Public symposium
- -, Jun. 2021, Japanese, Domestic conference-Oral presentation
- -, Jun. 2021, English, Domestic conferenceDelayed initiation of S-1 adjuvant chemotherapy impairs survival in patients with surgical resection for resectable pancreatic cancerOral presentation
- -, Jun. 2021, English, Domestic conferencePrognosis after total pancreatectomy and total remnant pancreatectomy for pancreatic cancerInvited oral presentation
- -, Jun. 2021, English, Domestic conferencePresent status of outpatient clinic for transplant patientsPublic symposium
- -, Jun. 2021, English, Domestic conferenceImpact of hepatectomy for advanced hepatocellular carcinoma with major portal vein tumor thrombusPublic symposium
- -, Jun. 2021, English, Domestic conferenceLong term survival following resection for ampullary carcinomaPublic symposium
- -, Jun. 2021, English, Domestic conference-Others
- -, Jun. 2021, English, Domestic conference-Others
- -, May 2021, Japanese, Domestic conference-Oral presentation
- -, May 2021, Japanese, Domestic conference-Public symposium
- -, May 2021, Japanese, Domestic conference-Oral presentation
- -, May 2021, Japanese, Domestic conference-Oral presentation
- -, May 2021, Japanese, Domestic conference-Oral presentation
- -, May 2021, Japanese, Domestic conferenceーOral presentation
- The 2022 Virtual International Congress of ILTS, ELITA and LICAGE, May 2021, English, International conferenceHow to control long term complications after liver transplantationPoster presentation
- The 2021 Virtual International Congress of ILTS, ELITA and LICAGE, May 2021, English, International conferenceThe impact of albumin-bilirubin score on short- and long-term survival after living-donor liver transplantation: a retrospective studyPoster presentation
- The 2021 Virtual International Congress of ILTS, ELITA and LICAGE, May 2021, English, International conferenceImpact of COVID-19 on the living donor liver transplantation programs in JapanPoster presentation
- The 2021 Virtual International Congress of ILTS, ELITA annd LICAGE, May 2021, English, International conferenceIndication of liver transplantation in the treatment of newly categorized acute-on-chronic liver failure in JapanPoster presentation
- -, Apr. 2021, English, Domestic conferenceIndication of liver transplantation in the treatment of newly categorized acute-on-chronic liver failure in japanOral presentation
- -, Apr. 2021, Japanese, Domestic conference-Public symposium
- -, Apr. 2021, Japanese, Domestic conference-Poster presentation
- -, Apr. 2021, Japanese, Domestic conference-Oral presentation
- -, Apr. 2021, Japanese, Domestic conference-Poster presentation
- -, Apr. 2021, Japanese, Domestic conference-Oral presentation
- -, Apr. 2021, Japanese, Domestic conference-Poster presentation
- -, Apr. 2021, Japanese, Domestic conference-Poster presentation
- -, Apr. 2021, Japanese, Domestic conference-Oral presentation
- -, Apr. 2021, Japanese, Domestic conference-Poster presentation
- -, Apr. 2021, Japanese, Domestic conference-Public symposium
- -, Apr. 2021, Japanese, Domestic conference-Poster presentation
- -, Mar. 2021, Japanese, Domestic conference-Others
- -, Mar. 2021, Japanese, Domestic conference-Others
- -, Mar. 2021, Japanese, Domestic conference-Public discourse
- -, Mar. 2021, Japanese, Domestic conference-Oral presentation
- -, Mar. 2021, Japanese, Domestic conference-Keynote oral presentation
- -, Mar. 2021, Japanese, Domestic conference-Others
- -, Mar. 2021, English, Domestic conference-Public symposium
- -, Mar. 2021, English, Domestic conference-Public symposium
- -, Mar. 2021, Japanese, Domestic conference-Others
- -, Feb. 2021, Japanese, Domestic conference-Public symposium
- -, Feb. 2021, Japanese, Domestic conference-Public symposium
- -, Feb. 2021, Japanese, Domestic conference-Others
- -, Feb. 2021, English, Domestic conference-Public symposium
- -, Feb. 2021, English, Domestic conference-Poster presentation
- -, Feb. 2021, English, Domestic conference-Poster presentation
- -, Feb. 2021, English, Domestic conference-Poster presentation
- -, Feb. 2021, English, Domestic conference-Poster presentation
- -, Feb. 2021, English, Domestic conference-Poster presentation
- -, Feb. 2021, English, Domestic conference-Poster presentation
- -, Feb. 2021, English, Domestic conference-Public symposium
- -, Feb. 2021, English, Domestic conference-Public symposium
- -, Feb. 2021, English, Domestic conference-Poster presentation
- -, Feb. 2021, English, Domestic conference-Invited oral presentation
- -, Feb. 2021, English, Domestic conference-Invited oral presentation
- -, Feb. 2021, Japanese, Domestic conference-Others
- -, Jan. 2021, Japanese, Domestic conference-Others
- -, Dec. 2020, Japanese, Domestic conference-Oral presentation
- -, Dec. 2020, Japanese, Domestic conference-Public symposium
- -, Dec. 2020, Japanese, Domestic conference-Public symposium
- -, Dec. 2020, Japanese, Domestic conference-Others
- 日本外科代謝栄養学会第57回学術集会, Dec. 2020, Japanese, Domestic conference-Public symposium
- 第45回日本外科系連合学会学術集会, Dec. 2020, Japanese, Domestic conference-Public symposium
- -, Dec. 2020, Japanese, Domestic conference-Public symposium
- -, Dec. 2020, Japanese, Domestic conference-Public symposium
- -, Dec. 2020, Japanese, Domestic conference-Public symposium
- -, Dec. 2020, Japanese, Domestic conference-Public symposium
- -, Dec. 2020, Japanese, Domestic conference-Public symposium
- -, Dec. 2020, Japanese, Domestic conference-Others
- -, Dec. 2020, Japanese, Domestic conference-Oral presentation
- -, Dec. 2020, Japanese, Domestic conference-Oral presentation
- -, Dec. 2020, Japanese, Domestic conference-Oral presentation
- -, Dec. 2020, Japanese, Domestic conference-Oral presentation
- -, Dec. 2020, Japanese, Domestic conference-Oral presentation
- -, Dec. 2020, Japanese, Domestic conference-Oral presentation
- -, Dec. 2020, Japanese, Domestic conference-Public symposium
- -, Dec. 2020, Japanese, Domestic conference-Public symposium
- -, Dec. 2020, Japanese, Domestic conference-Oral presentation
- -, Dec. 2020, Japanese, Domestic conference-Oral presentation
- -, Dec. 2020, Japanese, Domestic conference-Public symposium
- -, Dec. 2020, Japanese, Domestic conference-Oral presentation
- -, Dec. 2020, Japanese, Domestic conference-Oral presentation
- -, Dec. 2020, Japanese, Domestic conference-Oral presentation
- -, Dec. 2020, Japanese, Domestic conference-Public symposium
- -, Dec. 2020, Japanese, Domestic conference-Others
- -, Dec. 2020, Japanese, Domestic conference-Others
- -, Dec. 2020, Japanese, Domestic conference-Public symposium
- -, Nov. 2020, Japanese, Domestic conference-Others
- -, Nov. 2020, Japanese, Domestic conference-Poster presentation
- -, Nov. 2020, Japanese, Domestic conference-Poster presentation
- -, Nov. 2020, Japanese, Domestic conference-Poster presentation
- -, Nov. 2020, Japanese, Domestic conference-Public symposium
- -, Nov. 2020, Japanese, Domestic conference-Others
- -, Nov. 2020, Japanese, Domestic conference-Public symposium
- -, Nov. 2020, Japanese, Domestic conference-Public symposium
- -, Nov. 2020, Japanese, Domestic conference-Public symposium
- -, Nov. 2020, Japanese, Domestic conference-Public symposium
- -, Nov. 2020, Japanese, Domestic conference-Others
- -, Oct. 2020, Japanese, Domestic conference-Oral presentation
- -, Oct. 2020, Japanese, Domestic conference-Public symposium
- -, Oct. 2020, Japanese, Domestic conference-Public symposium
- -, Oct. 2020, Japanese, Domestic conference-Public symposium
- -, Oct. 2020, Japanese, Domestic conference-Others
- -, Oct. 2020, Japanese, Domestic conference-Others
- -, Oct. 2020, Japanese, Domestic conference-Public discourse
- -, Oct. 2020, Japanese, Domestic conference-Poster presentation
- -, Oct. 2020, Japanese, Domestic conference-Oral presentation
- -, Oct. 2020, Japanese, Domestic conference-Invited oral presentation
- -, Oct. 2020, Japanese, Domestic conference-Oral presentation
- -, Oct. 2020, Japanese, Domestic conference-Oral presentation
- -, Oct. 2020, Japanese, Domestic conference-Oral presentation
- -, Oct. 2020, Japanese, Domestic conference-Public symposium
- 第14回日本Acute Care Surgery学会学術集会, Sep. 2020, Japanese, Domestic conferenceがん化学療法中の急性胆嚢炎症例の検討Poster presentation
- -, Sep. 2020, Japanese, Domestic conference-Others
- -, Sep. 2020, Japanese, Domestic conference-Oral presentation
- -, Aug. 2020, Japanese, Domestic conference-Oral presentation
- -, Aug. 2020, Japanese, Domestic conference-Public symposium
- -, Aug. 2020, Japanese, Domestic conference-Public symposium
- -, Aug. 2020, Japanese, Domestic conference-Public symposium
- -, Aug. 2020, Japanese, Domestic conference-Others
- -, Aug. 2020, Japanese, Domestic conference-Oral presentation
- -, Aug. 2020, Japanese, Domestic conference-Poster presentation
- -, Aug. 2020, Japanese, Domestic conference-Poster presentation
- -, Aug. 2020, Japanese, Domestic conference-Poster presentation
- -, Aug. 2020, Japanese, Domestic conference-Poster presentation
- -, Aug. 2020, Japanese, Domestic conference-Poster presentation
- -, Aug. 2020, Japanese, Domestic conference-Poster presentation
- -, Aug. 2020, Japanese, Domestic conference-Poster presentation
- -, Aug. 2020, Japanese, Domestic conference-Poster presentation
- -, Aug. 2020, Japanese, Domestic conference-Poster presentation
- -, Aug. 2020, Japanese, Domestic conference-Poster presentation
- -, Aug. 2020, Japanese, Domestic conference-Oral presentation
- -, Aug. 2020, Japanese, Domestic conference-Poster presentation
- -, Aug. 2020, Japanese, Domestic conference-Oral presentation
- -, Aug. 2020, Japanese, Domestic conference-Poster presentation
- -, Aug. 2020, Japanese, Domestic conference-Oral presentation
- -, Aug. 2020, Japanese, Domestic conference-Oral presentation
- -, Aug. 2020, Japanese, Domestic conference-Others
- -, Aug. 2020, Japanese, Domestic conference-Public symposium
- -, Feb. 2020, Japanese, Domestic conference-Poster presentation
- -, Feb. 2020, Japanese, Domestic conference-Poster presentation
- -, Feb. 2020, Japanese, Domestic conference-Public symposium
- -, Feb. 2020, Japanese, Domestic conference-Public symposium
- -, Feb. 2020, Japanese, Domestic conference-Oral presentation
- -, Feb. 2020, Japanese, Domestic conference-Others
- -, Jan. 2020, Japanese, Domestic conference-Others
- -, Jan. 2020, English, Domestic conference-Poster presentation
- -, Jan. 2020, Japanese, Domestic conference-Public symposium
- -, Dec. 2019, Japanese, Domestic conference-Oral presentation
- -, Dec. 2019, Japanese, Domestic conference-Others
- -, Dec. 2019, Japanese, Domestic conference-Others
- -, Dec. 2019, Japanese, Domestic conference-Public symposium
- -, Dec. 2019, Japanese, Domestic conference-Public symposium
- -, Dec. 2019, Japanese, Domestic conference-Oral presentation
- -, Dec. 2019, Japanese, Domestic conference-Oral presentation
- -, Dec. 2019, Japanese, Domestic conference-Oral presentation
- -, Dec. 2019, Japanese, Domestic conference-Oral presentation
- -, Dec. 2019, Japanese, Domestic conference-Oral presentation
- -, Dec. 2019, Japanese, Domestic conference-Public symposium
- -, Dec. 2019, Japanese, Domestic conference-Public symposium
- -, Dec. 2019, Japanese, Domestic conference-Oral presentation
- -, Dec. 2019, Japanese, Domestic conference-Oral presentation
- -, Dec. 2019, Japanese, Domestic conference-Others
- -, Nov. 2019, Japanese, Domestic conference-Others
- -, Nov. 2019, Japanese, Domestic conference-Others
- -, Nov. 2019, Japanese, Domestic conference-Poster presentation
- -, Nov. 2019, Japanese, Domestic conference-Poster presentation
- -, Nov. 2019, Japanese, Domestic conference-Poster presentation
- -, Nov. 2019, Japanese, Domestic conference-Public symposium
- -, Nov. 2019, Japanese, Domestic conference-Others
- -, Nov. 2019, Japanese, Domestic conference-Poster presentation
- -, Nov. 2019, Japanese, Domestic conference-Invited oral presentation
- -, Nov. 2019, Japanese, Domestic conference-Oral presentation
- -, Nov. 2019, Japanese, Domestic conference-Oral presentation
- -, Nov. 2019, Japanese, Domestic conference-Poster presentation
- -, Nov. 2019, Japanese, Domestic conference-Poster presentation
- -, Nov. 2019, Japanese, Domestic conference-Poster presentation
- -, Nov. 2019, Japanese, Domestic conference-Public symposium
- -, Nov. 2019, Japanese, Domestic conference-Public symposium
- -, Nov. 2019, Japanese, Domestic conference-Public symposium
- -, Nov. 2019, Japanese, Domestic conference-Oral presentation
- -, Nov. 2019, Japanese, Domestic conference-Public symposium
- -, Nov. 2019, Japanese, Domestic conference-Public symposium
- -, Nov. 2019, Japanese, Domestic conference-Invited oral presentation
- -, Nov. 2019, Japanese, Domestic conference-Public symposium
- -, Nov. 2019, Japanese, Domestic conference-Public symposium
- -, Nov. 2019, Japanese, Domestic conference-Others
- -, Nov. 2019, Japanese, Domestic conference-Others
- -, Nov. 2019, Japanese, Domestic conference-Others
- -, Oct. 2019, Japanese, Domestic conference-Others
- -, Oct. 2019, Japanese, Domestic conference-Others
- -, Oct. 2019, Japanese, Domestic conference-Oral presentation
- -, Oct. 2019, Japanese, Domestic conference-Others
- -, Oct. 2019, Japanese, Domestic conference-Public symposium
- -, Oct. 2019, Japanese, Domestic conference-Poster presentation
- -, Oct. 2019, Japanese, Domestic conference-Poster presentation
- -, Oct. 2019, Japanese, Domestic conference-Oral presentation
- -, Oct. 2019, Japanese, Domestic conference-Oral presentation
- -, Oct. 2019, Japanese, Domestic conference-Oral presentation
- -, Oct. 2019, Japanese, Domestic conference-Oral presentation
- -, Oct. 2019, Japanese, Domestic conference-Oral presentation
- -, Oct. 2019, Japanese, Domestic conference-Oral presentation
- -, Oct. 2019, Japanese, Domestic conference-Oral presentation
- -, Oct. 2019, Japanese, Domestic conference-Oral presentation
- -, Oct. 2019, Japanese, Domestic conference-Oral presentation
- -, Oct. 2019, Japanese, Domestic conference-Oral presentation
- -, Oct. 2019, Japanese, Domestic conference-Poster presentation
- -, Oct. 2019, Japanese, Domestic conference-Public discourse
- -, Sep. 2019, Japanese, Domestic conference-Oral presentation
- -, Sep. 2019, Japanese, Domestic conference-Public symposium
- -, Sep. 2019, Japanese, Domestic conference-Public symposium
- 19th Congress of the European Society for Organ Transplantation (ESOT 2019), Sep. 2019, English, Denmark, International conferenceAssessment for the usefulness of ALBI score as a predictor of short-and long- term survival after living donor liver transplantation.Poster presentation
- 19th Congress of the European Society for Organ Transplantation (ESOT 2019), Sep. 2019, English, Denmark, International conferenceLiver Re-transplantation in JapanPoster presentation
- -, Sep. 2019, Japanese, Domestic conference-Public symposium
- -, Sep. 2019, Japanese, Domestic conference-Nominated symposium
- -, Sep. 2019, Japanese, Domestic conference-Public symposium
- -, Aug. 2019, Japanese, Domestic conference-Others
- -, Jul. 2019, Japanese, Domestic conference-Others
- -, Jul. 2019, Japanese, Domestic conference-Oral presentation
- -, Jul. 2019, Japanese, Domestic conference-Public symposium
- -, Jul. 2019, Japanese, Domestic conference-Public symposium
- -, Jul. 2019, Japanese, Domestic conference-Public symposium
- -, Jul. 2019, Japanese, Domestic conference-Public symposium
- -, Jul. 2019, Japanese, Domestic conference-Public symposium
- -, Jul. 2019, Japanese, Domestic conference-Others
- -, Jul. 2019, Japanese, Domestic conference-Others
- -, Jul. 2019, Japanese, Domestic conference-Poster presentation
- -, Jul. 2019, Japanese, Domestic conference-Poster presentation
- -, Jul. 2019, Japanese, Domestic conference-Poster presentation
- -, Jul. 2019, Japanese, Domestic conference-Poster presentation
- -, Jul. 2019, Japanese, Domestic conference-Poster presentation
- -, Jul. 2019, Japanese, Domestic conference-Poster presentation
- -, Jul. 2019, Japanese, Domestic conference-Poster presentation
- -, Jul. 2019, Japanese, Domestic conference-Public symposium
- -, Jul. 2019, Japanese, Domestic conference-Poster presentation
- -, Jul. 2019, Japanese, Domestic conference-Public symposium
- -, Jul. 2019, Japanese, Domestic conference-Invited oral presentation
- -, Jul. 2019, Japanese, Domestic conference-Poster presentation
- -, Jul. 2019, Japanese, Domestic conference-Poster presentation
- -, Jul. 2019, Japanese, Domestic conference-Invited oral presentation
- -, Jul. 2019, Japanese, Domestic conference-Public symposium
- -, Jul. 2019, Japanese, Domestic conference-Public symposium
- -, Jul. 2019, Japanese, Domestic conference-Poster presentation
- -, Jul. 2019, Japanese, Domestic conference-Invited oral presentation
- -, Jul. 2019, Japanese, Domestic conference-Others
- -, Jul. 2019, Japanese, Domestic conference-Poster presentation
- -, Jul. 2019, Japanese, Domestic conference-Others
- -, Jul. 2019, Japanese, Domestic conference-Others
- 第55回日本肝癌研究会, Jul. 2019, Japanese, Domestic conference-Oral presentation
- 第55回日本肝癌研究会, Jul. 2019, Japanese, Domestic conference-Public symposium
- 第55回日本肝癌研究会, Jul. 2019, Japanese, Domestic conference-Public symposium
- 第55回日本肝癌研究会, Jul. 2019, Japanese, Domestic conference-Public symposium
- 第55回日本肝癌研究会, Jul. 2019, Japanese, Domestic conference-Others
- 第41回日本癌局所療法研究会, Jun. 2019, Japanese, Domestic conference-Poster presentation
- 第41回日本癌局所療法研究会, Jun. 2019, Japanese, Domestic conference-Public symposium
- 第41回日本癌局所療法研究会, Jun. 2019, Japanese, Domestic conference-Others
- 第31回日本肝胆膵外科学会・学術集会, Jun. 2019, English, Domestic conferenceImpact of conversion surgery for advanced gallbladder cancerPublic symposium
- 第31回日本肝胆膵外科学会・学術集会, Jun. 2019, English, Domestic conferenceA case of hypereosinophilic syndrome developing eosinophilic cholecystitis and postoperative eosinophilic cholangitisPoster presentation
- 第31回日本肝胆膵外科学会・学術集会, Jun. 2019, English, Domestic conferenceSurgical spacer placement and proton radiotherapy for unresectable locally advanced pancreatic cancer nearby gastrointestinal tractPoster presentation
- 第31回日本肝胆膵外科学会・学術集会, Jun. 2019, English, Domestic conferenceLaparoscopic surgery does not reduce clinically relevant pancreatic fistula after stapled distal pancreatectomy -propensity score matched comparative study with open surgery-Poster presentation
- 第31回日本肝胆膵外科学会・学術集会, Jun. 2019, English, Domestic conferenceShort-term outcomes of clamp crush method with HARMONIC HD 1000i for laparoscopic liver resection for hepatocellular carcinomaPoster presentation
- 第31回日本肝胆膵外科学会・学術集会, Jun. 2019, English, Domestic conferenceAnalysis of hepatectomy for elderly patients with bile tract cancerPoster presentation
- 第31回日本肝胆膵外科学会・学術集会, Jun. 2019, English, Domestic conferencePancreatic body cancer with type1 autoimmune pancreatitis. A case reportPoster presentation
- 第31回日本肝胆膵外科学会・学術集会, Jun. 2019, English, Domestic conferenceClinical features of Lenvatinib for unresectable hepatocellular carcinoma Clinical features of Lenvatinib for unresectable hepatocellular carcinomaPublic symposium
- 第31回日本肝胆膵外科学会・学術集会, Jun. 2019, English, Domestic conferenceLiver re-transplantation in JapanPublic symposium
- 第31回日本肝胆膵外科学会・学術集会, Jun. 2019, English, Domestic conferenceContrast-enhanced Intraoperative ultrasonic cholangiography for real time biliary navigation in hepatobiliary surgeryPublic symposium
- 第31回日本肝胆膵外科学会・学術集会, Jun. 2019, English, Domestic conferenceThe management of biliary complications in laparoscopic liver resectionPublic symposium
- 第31回日本肝胆膵外科学会・学術集会, Jun. 2019, English, Domestic conferenceLaparoscopic Distal Pancreatectomy with Regional Lymph Nodes Dissection (LDPLD) for Pancreatic Adenocarcinoma -Our Surgical Technique and The Short-term Outcomes-Oral presentation
- 第31回日本肝胆膵外科学会・学術集会, Jun. 2019, English, Domestic conferenceOutcome of 14 patients with iatrogenic bile duct injuryPublic symposium
- 第31回日本肝胆膵外科学会・学術集会, Jun. 2019, English, Domestic conferenceModerators(Best Videos by Board-certified expert HBP surgeons)Others
- 第31回日本肝胆膵外科学会・学術集会, Jun. 2019, English, Domestic conferenceModerator(Educational Videos1)Others
- 第55回日本肝臓学会総会, May 2019, Japanese, Domestic conference-Public symposium
- 第55回日本肝臓学会総会, May 2019, Japanese, Domestic conference-Public symposium
- 第55回日本肝臓学会総会, May 2019, Japanese, Domestic conference-Public symposium
- 第55回日本肝臓学会総会, May 2019, Japanese, Domestic conference-Oral presentation
- 第55回日本肝臓学会総会, May 2019, Japanese, Domestic conference-Poster presentation
- 第55回日本肝臓学会総会, May 2019, Japanese, Domestic conference-Others
- 第73回手術手技研究会, May 2019, Japanese, Domestic conference-Oral presentation
- ILLS2019 The 2nd World Congress of the International Laparoscopic Liver Society, May 2019, English, International conferenceShort-term outcomes of clamp crush method with HARMONIC HD 1000i for laparoscopic liver resection for hepatocellular carcinomaPoster presentation
- ILLS2019 The 2nd World Congress of the International Laparoscopic Liver Society, May 2019, English, International conferenceEfficacy and feasibility of laparoscopic surgery for repeat hepatectomyPoster presentation
- 第105回日本消化器病学会総会, May 2019, Japanese, Domestic conference-Poster presentation
- 第105回日本消化器病学会総会, May 2019, Japanese, Domestic conference-Public symposium
- 第105回日本消化器病学会総会, May 2019, Japanese, Domestic conference-Public symposium
- 第105回日本消化器病学会総会, May 2019, Japanese, Domestic conference-Poster presentation
- 第133回日本外科学会定期学術集会, Apr. 2019, Japanese, Domestic conference-Poster presentation
- 第132回日本外科学会定期学術集会, Apr. 2019, Japanese, Domestic conference-Invited oral presentation
- 第131回日本外科学会定期学術集会, Apr. 2019, Japanese, Domestic conference-Poster presentation
- 第130回日本外科学会定期学術集会, Apr. 2019, Japanese, Domestic conference-Poster presentation
- 第129回日本外科学会定期学術集会, Apr. 2019, Japanese, Domestic conference-Poster presentation
- 第128回日本外科学会定期学術集会, Apr. 2019, Japanese, Domestic conference-Poster presentation
- 第127回日本外科学会定期学術集会, Apr. 2019, Japanese, Domestic conference-Poster presentation
- 第126回日本外科学会定期学術集会, Apr. 2019, Japanese, Domestic conference-Oral presentation
- 第125回日本外科学会定期学術集会, Apr. 2019, Japanese, Domestic conference-Poster presentation
- 第124回日本外科学会定期学術集会, Apr. 2019, Japanese, Domestic conference-Keynote oral presentation
- 第123回日本外科学会定期学術集会, Apr. 2019, Japanese, Domestic conference-Poster presentation
- 第122回日本外科学会定期学術集会, Apr. 2019, Japanese, Domestic conference-Poster presentation
- 第121回日本外科学会定期学術集会, Apr. 2019, Japanese, Domestic conference-Poster presentation
- 第120回日本外科学会定期学術集会, Apr. 2019, Japanese, Domestic conference-Public symposium
- 第119回日本外科学会定期学術集会, Apr. 2019, Japanese, Domestic conference-Others
- -, Jan. 2019, Japanese, Domestic conference-Public symposium
- 第11回神戸肝胆膵研究会, Mar. 2018, Japanese, 神戸肝胆膵研究会, 神戸, Domestic conference座長(特別講演)Others
- 神戸肝癌診療領域横断セミナー ~肝癌治療における新たなる知見~, Mar. 2018, Japanese, 診療領域横断セミナー ~肝癌治療における新たなる知見~, 神戸, Domestic conference開会の挨拶Others
- The 5th Yeungnam-Kasai HBP Surgeons Joint Meeting 2018, Mar. 2018, English, 和歌山県立医科大学, Daegu, Korea, International conferenceHistological and molecular characterization of intrahepatic bile duct cancers suggests an expanded definition of perihilar cholangiocarcinomaPoster presentation
- The 5th Yeungnam-Kasai HBP Surgeons Joint Meeting 2018, Mar. 2018, English, 和歌山県立医科大学, Daegu, Korea, International conferenceEfficacy of laparoscopic surgery for repeat liver resectionPoster presentation
- The 5th Yeungnam-Kasai HBP Surgeons Joint Meeting 2018, Mar. 2018, English, 和歌山県立医科大学, Daegu, Korea, International conferenceDelayed initiation of S-1 adjuvant chemotherapy impairs survival in patients with surgical resection for pancreatic cancerOral presentation
- 第46回近畿肝臓外科研究会, Feb. 2018, Japanese, 近畿肝臓外科研究会, 大阪, Domestic conference肝切除における当科独自の工夫:ソナゾイドを用いた術中胆道造影下超音波の有用性Oral presentation
- ISN frontiers meeting 2018, Feb. 2018, English, SN frontiers meeting, Tokyo, 東京, Domestic conferenceEstimated glomerular filtration rate declines associated with the reduction of kidney volume after liver transplantationPoster presentation
- -, Jan. 2018, Japanese, Domestic conference-Oral presentation
- Cancer VTE セミナー ~がんと静脈血栓塞栓症~, Jan. 2018, Japanese, 第一三共株式会社, 神戸, Domestic conference座長(講演)Others
- 平成29年度神戸医療機器創出イノベーションフォーラム 医療現場を中心とした医療機器産学共創プラットフォームの形成, Jan. 2018, Japanese, 神戸大学医学部付属病院, 神戸, Domestic conference座長Others
- 平成29年度神戸医療機器創出イノベーションフォーラム 医療現場を中心とした医療機器産学共創プラットフォームの形成, Jan. 2018, Japanese, 神戸大学医学部付属病院, 神戸, Domestic conference医療現場が求めるイノベーションの創出Oral presentation
- 第11回肝臓内視鏡外科研究会, Dec. 2017, Japanese, 東京医科歯科大学, 京都, Domestic conference腹腔鏡下肝前区域切除における課題Public symposium
- 第11回肝臓内視鏡外科研究会, Dec. 2017, Japanese, 東京医科歯科大学, 京都, Domestic conference腹腔鏡下肝切除の導入と発展Others
- 第34回近畿肝移植検討会プログラム, Dec. 2017, Japanese, 大阪大学大学院, 吹田, Domestic conference当院における肝移植後de novo 悪性腫瘍の検討Oral presentation
- 第30回日本内視鏡外科学会総会, Dec. 2017, Japanese, 京都大学, 京都, Domestic conference胆嚢・総胆管4Poster presentation
- 第11回肝臓内視鏡外科研究会, Dec. 2017, Japanese, 東京医科歯科大学, 京都, Domestic conference術中の胆管損傷に対するトラブル対処法を考えるPublic symposium
- 第30回日本内視鏡外科学会総会, Dec. 2017, Japanese, 京都大学, 京都, Domestic conference手術用3D内視鏡システムを用いた腹腔鏡下尾側膵切除術Oral presentation
- 第11回肝臓内視鏡外科研究会, Dec. 2017, Japanese, 東京医科歯科大学, 京都, Domestic conference再肝切除への腹腔鏡手術適応の妥当性についてPublic symposium
- 第30回日本内視鏡外科学会総会, Dec. 2017, Japanese, 京都大学, 京都, Domestic conference肝臓7Poster presentation
- 第30回日本内視鏡外科学会総会, Dec. 2017, Japanese, 京都大学, 京都, Domestic conference肝臓10Poster presentation
- 2017年度生命科学系学会合同年次大会(第40回日本分子生物学会), Dec. 2017, Japanese, 神戸国際展示場, Domestic conference炎症性疾患の新規診断技術の開発Poster presentation
- 第79回日本臨床外科学会総会, Nov. 2017, Japanese, 日本大学, 東京, Domestic conference膵癌に対するD2郭清を伴う腹腔鏡下膵体尾部切除(LAP-DPD2)の導入と当科の標準手技Public symposium
- 第1回神戸消化器学術講演会, Nov. 2017, Japanese, ミヤリサン製薬株式会社, 神戸, Domestic conference閉会の挨拶Others
- 第79回日本臨床外科学会総会, Nov. 2017, Japanese, 日本大学, 東京, Domestic conference当施設における腹腔鏡下肝切除の定型化Public symposium
- 第79回日本臨床外科学会総会, Nov. 2017, Japanese, 日本大学, 東京, Domestic conference当施設における肝前/後区域切除術での検討Public symposium
- 第79回日本臨床外科学会総会, Nov. 2017, Japanese, 日本大学, 東京, Domestic conference当科における若手外科医の獲得と育成の取り組みOral presentation
- 第79回日本臨床外科学会総会, Nov. 2017, Japanese, 日本大学, 東京, Domestic conference胆管侵襲を伴う進行肝細胞癌に対する治療戦略Oral presentation
- 第79回日本臨床外科学会総会, Nov. 2017, Japanese, 日本大学, 東京, Domestic conference生体肝移植後胆管合併症の対策と予防Oral presentation
- 第27回臨床内分泌代謝Update, Nov. 2017, Japanese, 臨床内分泌代謝Update, 神戸, Domestic conference術中SACIテストにて腫瘍核出術を行ったMEN1合併インスリノーマの1例パシレオチドを用いた先端巨大症の症例手術によって寛解後30年目に再発を認めた Cushing病の一例副腎髄質過形成疑い病変に原発性副甲状腺機能亢進症を合併した一例IgG4関連疾患と鑑別を要したラトケ嚢胞による下垂体炎の一例不適切TSH分泌症候群(SITSH)を呈し, 診断に苦慮したTSH産生下垂体腫瘍の一例非定型AHO、副腎不全を呈した偽性副甲状腺機能低下症(GNAS D156N)の一例特発性中枢性尿崩症にPRL単独欠損症を合併した一Poster presentation
- 神戸外科フォーラム, Nov. 2017, Japanese, 神戸大学, 福岡, Domestic conference司会(特別講演I)Others
- 第1回神戸消化器学術講演会, Nov. 2017, Japanese, ミヤリサン製薬株式会社, 神戸, Domestic conference座長(一般演題)Others
- 第79回日本臨床外科学会総会, Nov. 2017, Japanese, 日本大学, 東京, Domestic conference高度進行肝細胞癌における減量肝切除術の意義Public symposium
- 第79回日本臨床外科学会総会, Nov. 2017, Japanese, 日本大学, 東京, Domestic conference肝切除時の下大静脈損傷に対する出血制御Public symposium
- 第79回日本臨床外科学会総会, Nov. 2017, Japanese, 日本大学, 東京, Domestic conference肝硬変合併胆石症例に対する腹腔鏡下胆嚢摘出術Public symposium
- 第79回日本臨床外科学会総会, Nov. 2017, Japanese, 日本大学, 東京, Domestic conference肝原発神経内分泌腫瘍に対して肝切除を施行した1例Oral presentation
- 神戸外科フォーラム, Nov. 2017, Japanese, 神戸大学, 福岡, Domestic conference開会の挨拶Others
- 第79回日本臨床外科学会総会, Nov. 2017, Japanese, 日本大学, 東京, Domestic conferenceここを工夫した私の手術手技(肝)Others
- American Pancreatic Association Annual Meeting-2017, Nov. 2017, English, American Pancreatic Association, San Diego, USA, International conferenceSplenic Vein Involvement of Pancreatic Adenocarcinoma is an Adverse Prognostic Factor After Surgery in Consequence of Liver MetastasisPoster presentation
- American Pancreatic Association Annual Meeting-2017, Nov. 2017, English, American Pancreatic Association, San Diego, USA, International conferencePreoperative serum Elastase-1 Level is an Independent Risk Factor for Pancreatic Fistula After PancreaticoduodenectomyPoster presentation
- IASGO World Congress 2017 HBP SurG Meeting, Nov. 2017, English, IASGO Office, Lyon, France, International conferenceMultidisciplinary treatment for stage B,C hepatocellurar carcinomaPoster presentation
- IASGO World Congress 2017 HBP SurG Meeting, Nov. 2017, English, IASGO Office, Lyon, France, International conferenceImpact for prognosis after non-anatomical resection for hepatocellular carcinoma historically proven micro portal vein tumor thrombusPoster presentation
- IASGO World Congress 2017 HBP SurG Meeting, Nov. 2017, English, IASGO Office, Lyon, France, International conferenceHepatobiliary navigation surgery using contrast-enhanced intraoperative ultrasonic cholangiographyPoster presentation
- 第79回日本臨床外科学会総会, Nov. 2017, Japanese, 日本大学, 東京, Domestic conferenceHepatic hilar resectionOral presentation
- IASGO World Congress 2017 HBP SurG Meeting, Nov. 2017, English, IASGO Office, Lyon, France, International conferenceDevelopment of a new biodegradable operative clip made of a magnesium alloy: evaluation of its safety and tolerabilityPoster presentation
- 第79回日本臨床外科学会総会, Nov. 2017, Japanese, 日本大学, 東京, Domestic conference10cm以上の大型肝細胞癌に対する肝切除の意義Oral presentation
- 第15回日本消化器外科学会(JDDW2017), Oct. 2017, Japanese, 岐阜大学大学院, 福岡, Domestic conference膵体尾部癌における脾静脈浸潤は早期肝転移再発のリスク因子であるPoster presentation
- 第12回膵癌術前治療研究会PREP2017, Oct. 2017, Japanese, 広島大学大学院, 広島県・広島市, Domestic conference膵癌切除先行治療における早期再発からみた術前治療適格症例選択の可能性Public symposium
- 第15回日本消化器外科学会(JDDW2017), Oct. 2017, Japanese, 岐阜大学大学院, 福岡, Domestic conference膵管に沿った曲面任意多段面再構成画像(Curved MPR)の有用性Poster presentation
- 第21回日本肝臓学会大会(JDDW2017), Oct. 2017, Japanese, 信州大学, 福岡, Domestic conference非B非C肝細胞癌に対する外科切除例の検討Oral presentation
- 第21回日本肝臓学会大会(JDDW2017), Oct. 2017, Japanese, 信州大学, 福岡, Domestic conference当科における難治性腹水に対するDever型腹腔静脈シャントの成績Poster presentation
- 第59回日本消化器病学会大会(JDDW2017), Oct. 2017, Japanese, 杏林大学, 福岡, Domestic conference多発進行肝癌に対する集学的治療Public symposium
- 第15回日本消化器外科学会(JDDW2017), Oct. 2017, Japanese, 岐阜大学大学院, 福岡, Domestic conference切除困難幹細胞癌における粒子線治療の可能性Poster presentation
- 第59回日本消化器病学会(JDDW2017), Oct. 2017, Japanese, 杏林大学, 福岡, Domestic conference術中Shear Wave Elastgraphyによる肝硬度測定と肝線維化診断Poster presentation
- 第15回日本消化器外科学会(JDDW2017), Oct. 2017, Japanese, 岐阜大学大学院, 福岡, Domestic conference腫瘍マーカーおよび炎症による胆道癌患者の層別化Poster presentation
- 第2回神戸大学医工学連携セミナー, Oct. 2017, Japanese, 神戸大学, 神戸, Domestic conference医療機器開発の実際Public discourse
- 第53回日本胆道学会学術集会, Sep. 2017, Japanese, 山形大学医学部第一外科, 山形, Domestic conference膵胆管合流異常を伴う胆嚢管癌の1例Poster presentation
- 第40回日本膵・胆管合流異常研究会, Sep. 2017, Japanese, 九州大学大学院医学研究院, 福岡, Domestic conference膵・胆管合流異常合併胆嚢癌の検討Oral presentation
- 第200回近畿外科学会, Sep. 2017, Japanese, 京都府立医科大学, 京都, Domestic conference嚢胞性肝腫瘍と鑑別が困難であった単純性肝嚢胞の1切除例Oral presentation
- 第53回日本胆道学会学術集会, Sep. 2017, Japanese, 山形大学医学部第一外科, 山形, Domestic conference肉眼分類に基づく胆嚢癌の臨床病理学的検討Oral presentation
- 第53回日本移植学会総会, Sep. 2017, Japanese, 旭川医科大学 外科学講座 消化器病態外科学分野, 旭川, Domestic conference当施設による臓器提供推進への取り組みOral presentation
- 第200回近畿外科学会, Sep. 2017, Japanese, 京都府立医科大学, 横浜, Domestic conference当科における切除可能膵癌に対する術前治療の経験Oral presentation
- 第53回日本移植学会総会, Sep. 2017, Japanese, 旭川医科大学 外科学講座 消化器病態外科学分野, 旭川, Domestic conference当院の脳死肝移植チームにおける現状から見えてきたものOral presentation
- 第53回日本移植学会総会, Sep. 2017, Japanese, 旭川医科大学 外科学講座 消化器病態外科学分野, 旭川, Domestic conference当院における膵移植後社会復帰の現状と問題点Oral presentation
- 第53回日本移植学会総会, Sep. 2017, Japanese, 旭川医科大学 外科学講座 消化器病態外科学分野, 旭川, Domestic conference当院におけるアルコール性肝硬変に対する肝移植患者の社会復帰の現状Oral presentation
- 第53回日本胆道学会学術集会, Sep. 2017, Japanese, 山形大学医学部第一外科, 山形, Domestic conference胆嚢癌疑いで開腹手術を施行した両性胆嚢疾患の検討Oral presentation
- 第53回日本胆道学会学術集会, Sep. 2017, Japanese, 山形大学医学部第一外科, 山形, Domestic conference胆管・十二指腸メタリックステント挿入の3年後に治療切除しえた進行十二指腸癌の1例Poster presentation
- 第53回 日本移植学会総会, Sep. 2017, Japanese, 日本移植学会, Asahikawa, 旭川, Domestic conference腎容積の変化にも着目した、肝移植後の慢性腎臓病(CKD)に関する検討Poster presentation
- 第53回 日本移植学会総会, Sep. 2017, Japanese, 日本移植学会, Asahikawa, 旭川, Domestic conference肝移植後腎機能障害に対し腎生検を施行した2例の検討[Invited]Invited oral presentation
- 第9回Acute Care Surgery学会学術集会, Sep. 2017, Japanese, 東北大学, 京都, Domestic conference開心術後に手術を施行した急性胆嚢炎症例の検討Poster presentation
- 第20回近畿外科病態研究会, Sep. 2017, Japanese, 大阪国際がんセンター, 大阪, Domestic conference「重症急性膵炎後の胆管癌患者に膵頭十二指腸切除を施行し、術後膵液瘻と被包化壊死(WON)の感染により横行結腸瘻を認めた一例」Oral presentation
- 第53回日本移植学会総会, Sep. 2017, Japanese, 旭川医科大学 外科学講座 消化器病態外科学分野, 旭川, Domestic conferenceドナーを増やすために移植医ができることOral presentation
- 第53回日本移植学会総会, Sep. 2017, Japanese, 旭川医科大学 外科学講座 消化器病態外科学分野, 旭川, Domestic conferenceグラフと不全の原因と再移植Others
- 第44回日本膵切研究会, Aug. 2017, Japanese, 横浜市立大学 消化器・腫瘍外科学, 京都, Domestic conference膵頭十二指腸切除における膵管不完全外瘻ドレナージPoster presentation
- 第44回日本膵切研究会, Aug. 2017, Japanese, 横浜市立大学 消化器・腫瘍外科学, 京都, Domestic conference当科における切除可能膵癌に対する術前治療の経験Poster presentation
- 第48回日本膵臓学会大会, Jul. 2017, Japanese, 関西医科大学 内科学第三講座(消化器肝臓内科), 京都, Domestic conference膵神経内分泌腫瘍における主膵管浸潤の臨床的意義Oral presentation
- 第72回日本消化器外科学会総会, Jul. 2017, Japanese, 金沢大学 消化器・腫瘍・再生外科学, 金沢, Domestic conference膵癌術前精査におけるGd-EOB-DPTA造影MRIと審査腹腔鏡の位置づけOral presentation
- 第72回日本消化器外科学会総会, Jul. 2017, Japanese, 金沢大学 消化器・腫瘍・再生外科学, 金沢, Domestic conference腹腔鏡下尾側膵切除術における手技の工夫Oral presentation
- 第72回日本消化器外科学会総会, Jul. 2017, Japanese, 金沢大学 消化器・腫瘍・再生外科学, 金沢, Domestic conference病理組織像から見た肝内胆管癌の分類及び画像的特徴の検討Public symposium
- 第72回日本消化器外科学会総会, Jul. 2017, Japanese, 金沢大学 消化器・腫瘍・再生外科学, 金沢, Domestic conference肺再生を考慮した生体肝移植における肝静脈再建の工夫Public symposium
- 第72回日本消化器外科学会総会, Jul. 2017, Japanese, 金沢大学 消化器・腫瘍・再生外科学, 金沢, Domestic conference独自技術を駆使した高度進行肝癌に対する外科集学的治療Public symposium
- 第72回日本消化器外科学会総会, Jul. 2017, Japanese, 金沢大学 消化器・腫瘍・再生外科学, 金沢, Domestic conference当科における腹腔鏡下肝切除の実際と工夫Oral presentation
- 第72回日本消化器外科学会総会, Jul. 2017, Japanese, 金沢大学 消化器・腫瘍・再生外科学, 金沢, Domestic conference当院での安全・安心な膵腎移植への取り組みOral presentation
- 第53回日本肝癌研究会, Jul. 2017, Japanese, 東京大学, 東京, Domestic conference超高齢者肝癌患者に対する肝切除術Oral presentation
- 第72回日本消化器外科学会総会, Jul. 2017, Japanese, 金沢大学 消化器・腫瘍・再生外科学, 金沢, Domestic conference胆道癌の早期再発危険因子の検討Oral presentation
- 第72回日本消化器外科学会総会, Jul. 2017, Japanese, 金沢大学 消化器・腫瘍・再生外科学, 金沢, Domestic conference術前分枝鎖アミノ酸飲料が膵頭十二指腸切除後の代謝に与える影響Public symposium
- 第72回日本消化器外科学会総会, Jul. 2017, Japanese, 金沢大学 消化器・腫瘍・再生外科学, 金沢, Domestic conference自然退縮をきたした肝細胞癌の5例Oral presentation
- 第72回日本消化器外科学会総会, Jul. 2017, Japanese, 金沢大学 消化器・腫瘍・再生外科学, 金沢, Domestic conference細径膵管に対する膵空腸接合手技と成績Oral presentation
- 第72回日本消化器外科学会総会, Jul. 2017, Japanese, 金沢大学 消化器・腫瘍・再生外科学, 金沢, Domestic conference高度進行胆嚢癌に対する術前化学療法併用での外科切除成績の改善Public symposium
- 第53回日本肝癌研究会, Jul. 2017, Japanese, 東京大学, 東京, Domestic conference肝切除(4)Others
- 第53回日本肝癌研究会, Jul. 2017, Japanese, 東京大学, 東京, Domestic conference肝静脈腫瘍栓を有する肝細胞癌に対する外科的切除の成績Oral presentation
- 第53回日本肝癌研究会, Jul. 2017, Japanese, 東京大学, 東京, Domestic conference肝細胞癌の下大静脈腫瘍栓に対する術式選択 ー自科のみか心臓血管外科とのコラボレーションかーPublic symposium
- 第72回日本消化器外科学会総会, Jul. 2017, Japanese, 金沢大学 消化器・腫瘍・再生外科学, 金沢, Domestic conference肝細胞癌のoncologic emergencyに対する治療戦略:Vp4,Vv3Public symposium
- 第72回日本消化器外科学会総会, Jul. 2017, Japanese, 金沢大学 消化器・腫瘍・再生外科学, 金沢, Domestic conferenceマグネシウム合金を用いた新規生体吸収性外科クリップの開発:イヌ胆嚢摘出モデルでの安全性と忍容性の検討Public symposium
- 第48回日本膵臓学会大会, Jul. 2017, Japanese, 関西医科大学 内科学第三講座(消化器肝臓内科), 金沢, Domestic conferenceTis/T1 膵癌の診断と治療戦略Public symposium
- 第72回日本消化器外科学会総会, Jul. 2017, Japanese, 金沢大学 消化器・腫瘍・再生外科学, 金沢, Domestic conferenceStageB,C肝細胞癌に対する集学的治療Public symposium
- 第53回日本肝癌研究会, Jul. 2017, Japanese, 東京大学, 東京, Domestic conferenceBCLC intermediate stage 肝癌に対する切除適応の検討Public symposium
- 第39回日本がん局所療法研究会, Jun. 2017, Japanese, 京都府立医科大学, 京都, Domestic conference傍大動脈リンパ節を含む多発リンパ節転移を伴った膵VIP 産生腫瘍の切除例Oral presentation
- 第35回日本肝移植研究会, Jun. 2017, Japanese, 大阪大学大学院, 大阪, Domestic conference脳死肝移植手術におけるサイズミスマッチグラフトに対する静脈吻合の工夫Oral presentation
- 第35回日本肝移植研究会, Jun. 2017, Japanese, 大阪大学大学院, 大阪, Domestic conference脳死肝移植後の虚血性胆管障害の治療経過中に肛門部胆管癌を発症した一例Oral presentation
- 第35回日本肝移植研究会, Jun. 2017, Japanese, 大阪大学大学院, 大阪, Domestic conference当科における肝移植後のde novo悪性腫瘍の検討Oral presentation
- 第35回日本肝移植研究会, Jun. 2017, Japanese, 大阪大学大学院, 大阪, Domestic conference長期経過Others
- 第39回日本がん局所療法研究会, Jun. 2017, Japanese, 京都府立医科大学, 京都, Domestic conference胆管上皮内腫瘍(BilIN-3)の切除後に発生した遠位胆管癌の1 切除例Oral presentation
- 第35回日本肝移植研究会, Jun. 2017, Japanese, 大阪大学大学院, 大阪, Domestic conference肝移植後胆管合併症の頻度とIVR-内視鏡的アプローチによる治療成績の検討Oral presentation
- 6th A-PHPBA 29th JSHBPS, Jun. 2017, English, The University of Tokyo, Yokohama, Japan, International conferencePortal vein reconstruction technique with portal vein thrombus for liver tranplantationPoster presentation
- 6th A-PHPBA 29th JSHBPS, Jun. 2017, English, The University of Tokyo, Yokohama, Japan, International conferenceLiver2Others
- 6th A-PHPBA 29th JSHBPS, Jun. 2017, English, The University of Tokyo, Yokohama, Japan, International conferenceExpanded indications of hepatocellular carcinoma by the two-stage treatment using spacer surgery and particle beam radiotherapyOral presentation
- 6th A-PHPBA 29th JSHBPS, Jun. 2017, English, The University of Tokyo, Yokohama, Japan, International conferenceDual treatment for hepatocellular carcinoma with portal vein tumor thrombusOral presentation
- 6th A-PHPBA 29th JSHBPS, Jun. 2017, English, The University of Tokyo, Yokohama, Japan, International conferenceA Novel Technique of Intraoperative Identification of Biliary Drainage Areas in the Liver after Hepatobiliary Resection for Perihilar cholangicarcinomaPoster presentation
- 神戸大学消化器癌セミナー, May 2017, Japanese, 神戸大学, 神戸, Domestic conference胃癌セッションOthers
- 第117回日本外科学会定期学術集会, Apr. 2017, Japanese, 日本外科学会, 横浜, Domestic conference膵神経内分泌腫瘍における術前主膵管狭窄は予後不良因子であるOral presentation
- 第117回日本外科学会定期学術集会, Apr. 2017, Japanese, 日本外科学会, 横浜, Domestic conference膵癌術前精査におけるEOB-MRIと審査腹腔鏡の意義Poster presentation
- 第117回日本外科学会定期学術集会, Apr. 2017, Japanese, 日本外科学会, 横浜, Domestic conference閉塞性黄疸に対する胆汁返還と周術期感染性合併症との関連に関する検討Poster presentation
- 第117回日本外科学会定期学術集会, Apr. 2017, Japanese, 日本外科学会, 横浜, Domestic conference腹腔鏡下脾動静脈温存脾温存膵体尾部切除術の成績と課題Poster presentation
- 第117回日本外科学会定期学術集会, Apr. 2017, Japanese, 日本外科学会, 横浜, Domestic conference胆道癌手術症例におけるinflammation-based prognostic scoreおよび腫瘍マーカーの意義Poster presentation
- 第103回日本消化器病学会総会, Apr. 2017, Japanese, 日本消化器病学会, 東京, Domestic conference神戸大学における劇症肝炎に対するプログラムPublic symposium
- 第117回日本外科学会定期学術集会, Apr. 2017, Japanese, 日本外科学会, 横浜, Domestic conference高齢膵癌患者に対する切除成績と課題Poster presentation
- 第117回日本外科学会定期学術集会, Apr. 2017, Japanese, 日本外科学会, 横浜, Domestic conference肝内胆管癌と混合型肝癌の臨床病理学的検討Poster presentation
- 第117回日本外科学会定期学術集会, Apr. 2017, Japanese, 日本外科学会, 横浜, Domestic conference肝切除における術中超音波を用いた胆道ナビゲーションサージャリーの現状と将来展望Public symposium
- 第117回日本外科学会定期学術集会, Apr. 2017, Japanese, 日本外科学会, 横浜, Domestic conference下大静脈腫瘍栓合併肝細胞癌に対する粒子線と肝切除のMatched pair analysisによる治療成績の比較検討Oral presentation
- 第117回日本外科学会定期学術集会, Apr. 2017, Japanese, 日本外科学会, 横浜, Domestic conferencesoft pancreasの膵空腸吻合手技と残膵内分泌能の評価Poster presentation
- 第103回日本消化器病学会総会, Apr. 2017, Japanese, 日本消化器病学会, 東京, Domestic conferenceC型慢性肝炎に対するDAA治療:肝細胞癌根治切除例の検討Poster presentation
- 第103回日本消化器病学会総会, Apr. 2017, Japanese, 日本消化器病学会, 東京, Domestic conferenceBCLC-Bの亜分類における肝細胞癌切除例の定量的因子を用いた検討Public symposium
- 第44回日本膵・膵島移植研究会, Mar. 2017, Japanese, 京都大学, 京都, Domestic conference膵腎同時移植後グラフト十二指腸穿孔 により膵グラフトを摘出し、膵臓再移植を行った1例Others
- 第53回日本腹部救急医学会, Mar. 2017, Japanese, 那須赤十字病院, 横浜, Domestic conference胆道癌における術前胆管炎Gradeは予後と相関Oral presentation
- 第21回兵庫粒子線治療研究会, Mar. 2017, Japanese, 兵庫県立粒子線医療センター, 神戸, Domestic conference仙骨脊索腫に対する体内空間可変粒子線治療の長期成績Public discourse
- 平成28年度神戸医療機器創出イノベーションフォーラム-現場のひらめきを製品へ-, Mar. 2017, Japanese, 神戸大学医学部付属病院, 神戸, Domestic conference生体分解性外科用クリップの開発Oral presentation
- 医工学連携セミナー, Mar. 2017, Japanese, 神戸大学, 神戸, Domestic conference座長(各施設演題)Others
- 第53回日本腹部救急医学会, Mar. 2017, Japanese, 那須赤十字病院, 横浜, Domestic conference黄色肉芽腫性胆嚢炎に合併した胆嚢十二指腸瘻の1例Oral presentation
- 第23回肝血流動体・機能イメージ研究会, Feb. 2017, Japanese, 近畿大学, 大阪, Domestic conference著明なAP shuntを伴う両葉多発進行肝細胞癌に対する術前経皮的肝灌流化学療法Oral presentation
- Nanotechnoligy in cancer drug delivery: from basics to clinical medicine, Feb. 2017, English, 神戸大学, Kobe, Japan, International conferencePercutaneous hepatic venous isolation and extracorporeal charcoal hemoperfusion for high-dose intra-arterial chemotherapy in patients with hepatocellular carcinomaOral presentation
- 2nd Eastern & Western association Liver Tumors, Jan. 2017, English, Tohoky University School of Medicine, Sendai, Japan, International conferenceMultidisciplinary therapy for multiple hepatocellurar carcinomaOral presentation
- 2nd Eastern & Western association Liver Tumors, Jan. 2017, English, Tohoky University School of Medicine, Sendai, Japan, International conferenceExpanden indications of hepatocellular carcinoma by the two-stage treatment using spacer surgery and particle beam radiotherapyPoster presentation
- 第78回日本臨床外科学会総会, Nov. 2016, Japanese, 東邦大学, 東京, Domestic conference膵神経内分泌腫瘍(PNET)リンパ節転移の術前リスク評価と治療方針Public symposium
- 第78回日本臨床外科学会総会, Nov. 2016, Japanese, 東邦大学, 東京, Domestic conference胆管内浸潤を呈した大腸癌肝転移の一例Poster presentation
- 第78回日本臨床外科学会総会, Nov. 2016, Japanese, 東邦大学, 東京, Domestic conference治療切除困難・不可能な進行肝細胞癌に対する術前PIHPの有用性の検討Public symposium
- 第78回日本臨床外科学会総会, Nov. 2016, Japanese, 東邦大学, 東京, Domestic conference巨大肝腫瘍における肝右葉切除の定型化〜出血量低減を目指して〜Public symposium
- 第78回日本臨床外科学会総会, Nov. 2016, Japanese, 東邦大学, 東京, Domestic conference肝実質内に明らかな肝細胞癌を認めず門脈腫瘍栓のみを認めた1例Poster presentation
- 第39回日本分子生物学会年会, Nov. 2016, Japanese, パシフィコ横浜, Domestic conference肝疾患の新規診断技術の開発Poster presentation
- 第14回日本消化器外科学会大会(JDDW2016), Nov. 2016, Japanese, 山形大学, 神戸, Domestic conference肝癌外科治療後のSorafenib投与症例の検討とTACE併用療法の位置づけPoster presentation
- 第78回日本臨床外科学会総会, Nov. 2016, Japanese, 東邦大学, 東京, Domestic conferenceVp4を伴う肝細胞癌に対する治療戦略Poster presentation
- Asian Pacific Digestive Week(APDW), Nov. 2016, English, Kobe convention center, Kobe, International conferenceThe Predictive power of serum tumor markers varies according to tumor size in patients with hepatocellular carcinomaOral presentation
- Asian Pacific Digestive Week(APDW), Nov. 2016, English, Kobe convention center, Kobe, International conferenceStaging laparoscopy for pancreatic cancerPoster presentation
- The 29th Annual Meeting of the Japanese Society for Radiation Oncology, Nov. 2016, Japanese, Japanese Society for Radiation Oncology, 京都, Domestic conferenceNext-stage Bioabsorbable Spacer in Particle TherapyPoster presentation
- Asian Pacific Digestive Week(APDW), Nov. 2016, English, Kobe convention center, Kobe, International conferenceImpact for prognosis after non-anatomical resection for hepatocellular carcinoma historically proven micro portal vein tumor thrombusPoster presentation
- Asian Transplantation Week 2016, Oct. 2016, English, Kobe convention center, Korea, International conferenceNovel technique of contrast-enhanced intraoperative ultrasonic cholangiography in living donor hepatectomyPoster presentation
- 第52回日本移植学会総会, Sep. 2016, Japanese, 東邦大学, 東京, Domestic conference神戸大学における肝移植後腎機能障害に対する取り組みPublic symposium
- 第11回肝癌治療シミュレーション研究会, Sep. 2016, Japanese, 兵庫医科大学, 大阪, Domestic conference肝胆道手術におけるイノベーション:ソナゾイド術中超音波下胆道造影を用いた胆道ナビゲーションPoster presentation
- 26th International congress of the transplantation society TTS2016, Aug. 2016, English, TTS, 香港, International conferenceV5/V8 hepatic vein thrombus after left lobe donation surgeryPoster presentation
- 26th International congress of the transplantation society TTS2016, Aug. 2016, English, TTS, 香港, International conferenceThe clinical relevance of one-way zero HLA mismatches among post-pancreas transplant acute graft-versus host disease populationPoster presentation
- 26th International congress of the transplantation society TTS2016, Aug. 2016, English, TTS, 香港, International conferenceThe best level of recipient's biliary duct for anastomosis to prevent postoperative anastomosis stricturePoster presentation
- 第47回日本膵臓学会大会・第20回国際膵臓学会・第6回アジアオセアニア膵臓学会, Aug. 2016, English, 三重大学, 仙台, International conferenceSolid pseudopapillary neoplasms of the pancreas: an experience of nine cases from a single intitutionPoster presentation
- 第47回日本膵臓学会大会・第20回国際膵臓学会・第6回アジアオセアニア膵臓学会, Aug. 2016, English, 三重大学, 仙台, International conferencePreoperative independent prognostic factors in patients with borderline resectable pancreatic adenocarcinoma following curative resection : neutrophil-lymphocyte ratio and platelet-lymphocyte ratios.Poster presentation
- 第47回日本膵臓学会大会・第20回国際膵臓学会・第6回アジアオセアニア膵臓学会, Aug. 2016, English, 三重大学, 仙台, International conferenceLaparoscopic distal pancreatectomy: effects of standardizationPublic symposium
- 26th International congress of the transplantation society TTS2016, Aug. 2016, English, TTS, 香港, International conferenceDeclatasvir plus asunaprevir as interferon-free regimen for recurrent hepatitis C virus infection after liver transplantation: A preliminary studyOral presentation
- 26th International congress of the transplantation society TTS2016, Aug. 2016, English, TTS, 香港, International conferenceContrast-enhanced intraoperative ultrasonic cholangiography for real-time biliary navigation in hepatobiliary surgeryPoster presentation
- 第34回日本肝移植研究会, Jul. 2016, Japanese, 旭川医科大学, 北海道, Domestic conference脳死肝移植後早期脂肪肝に対し経腸栄養を用いた栄養管理により改善を得た一例Public discourse
- 第34回日本肝移植研究会, Jul. 2016, Japanese, 旭川医科大学, 北海道, Domestic conference当施設におけるドナー啓発アクションPoster presentation
- 第52回日本肝癌研究会, Jul. 2016, Japanese, 武蔵野赤十字病院, 東京, Domestic conference多発進行肝癌に対する術前・術後経皮的肝灌流化学療法を併施する肝切除の役割Poster presentation
- 第71回日本消化器外科学会総会, Jul. 2016, Japanese, 徳島大学, 徳島, Domestic conference神戸大学における再発肝癌の治療戦略Oral presentation
- 第71回日本消化器外科学会総会, Jul. 2016, Japanese, 徳島大学, 徳島, Domestic conference新規マグネシウム合金を用いた生体吸収性外科クリップの開発Poster presentation
- 第71回日本消化器外科学会総会, Jul. 2016, Japanese, 徳島大学, 徳島, Domestic conference新しい生体吸収性マグネシウム合金クリップの開発とラット肝切除モデルにおける応用Oral presentation
- 第34回日本肝移植研究会, Jul. 2016, Japanese, 旭川医科大学, 北海道, Domestic conference国内における脳死による再移植の現状と課題Poster presentation
- 第52回日本肝癌研究会, Jul. 2016, Japanese, 武蔵野赤十字病院, 東京, Domestic conference血小板減少合併肝細胞癌に対する外科切除例の検討Oral presentation
- 第71回日本消化器外科学会総会, Jul. 2016, Japanese, 徳島大学, 徳島, Domestic conference巨大肝癌に対する当施設のStrategyPublic symposium
- 第52回日本肝癌研究会, Jul. 2016, Japanese, 武蔵野赤十字病院, 東京, Domestic conference肝胆道手術におけるイノベーション:ソナゾイド術中超音波下胆道造影を用いた胆道ナビゲーションOral presentation
- 第71回日本消化器外科学会総会, Jul. 2016, Japanese, 徳島大学, 徳島, Domestic conference肝臓:症例報告2Poster presentation
- 第71回日本消化器外科学会総会, Jul. 2016, Japanese, 徳島大学, 徳島, Domestic conference肝静脈腫瘍栓を合併した肝細胞癌の予後に関する検討Poster presentation
- 第34回日本肝移植研究会, Jul. 2016, Japanese, 旭川医科大学, 北海道, Domestic conference肝移植後C型肝炎再感染に対するDaclatasvir / Asunaprevirの治療成績Poster presentation
- 第52回日本肝癌研究会, Jul. 2016, Japanese, 武蔵野赤十字病院, 東京, Domestic conference右心房内腫瘍栓を有する肝細胞癌に対する外科的切除Poster presentation
- 第71回日本消化器外科学会総会, Jul. 2016, Japanese, 徳島大学, 徳島, Domestic conferenceDeceased donor liver transplantation for the treatment of graft failure in JapanPoster presentation
- 第28回日本肝胆膵外科学会・学術集会, Jun. 2016, Japanese, 大阪大学, 大阪, Domestic conference大腸癌術後に異時性に膵・肝転移をきたし外科的切除を行った1例Poster presentation
- 第41回日本外科系連合学会学術集会, Jun. 2016, Japanese, 兵庫医科大学, 大阪, Domestic conference他科とのコラボレーション手術(1)Oral presentation
- 第28回日本肝胆膵外科学会・学術集会, Jun. 2016, Japanese, 大阪大学, 大阪, Domestic conference生体肝移植における高度門脈血栓症に対する吻合方法に関する検討Oral presentation
- 第28回日本肝胆膵外科学会・学術集会, Jun. 2016, Japanese, 大阪大学, 大阪, Domestic conference高度脈管侵襲を伴う肝細胞癌の治療戦略Others
- 第28回日本肝胆膵外科学会・学術集会, Jun. 2016, Japanese, 大阪大学, 大阪, Domestic conference高度血管侵襲陽性肝細胞癌に対する肝切除Others
- 第28回日本肝胆膵外科学会・学術集会, Jun. 2016, Japanese, 大阪大学, 大阪, Domestic conference巨大肝細胞癌に対する右肝切除術の工夫Others
- 第28回日本肝胆膵外科学会・学術集会, Jun. 2016, Japanese, 大阪大学, 大阪, Domestic conference肝移植の適応評価についての再考Public discourse
- 第28回日本肝胆膵外科学会・学術集会, Jun. 2016, Japanese, 大阪大学, 大阪, Domestic conference下大静脈浸潤肝癌に対する肝切除Oral presentation
- 第28回日本肝胆膵外科学会・学術集会, Jun. 2016, Japanese, 大阪大学, 大阪, Domestic conferenceビデオセッション13 血管合併切除を伴う肝切除1Oral presentation
- 24th International congress of the European Association for Endoscopic Surgery (E.A.E.S), Jun. 2016, English, Giovanni Zaninotto, Amsterdam, International conferenceSimultaneous Laparoscopic Resection of Colorectal Cancer and Synchronous Metastatic Liver Tumor: a case reportPoster presentation
- 24th International congress of the European Association for Endoscopic Surgery (E.A.E.S), Jun. 2016, English, Giovanni Zaninotto, Amsterdam, International conferenceLaparoscopic Distal Pancreatectomy; Our Standardized ProcedurePoster presentation
- 24th International congress of the European Association for Endoscopic Surgery (E.A.E.S), Jun. 2016, English, Giovanni Zaninotto, Amsterdam, International conferenceLaparoscopic deroofing of Huge symptomatic liver cysts with greater ometum flapPoster presentation
- 24th International congress of the European Association for Endoscopic Surgery (E.A.E.S), Jun. 2016, English, Giovanni Zaninotto, Amsterdam, International conferenceA management of pure laparoscopic heaptectomy in our institutePoster presentation
- DDW2016, May 2016, English, DDW, California, International conferencePrognostic Factors After Surgical Resection for Patients With Biliary Tract CancerOral presentation
- DDW2016, May 2016, English, DDW, California, International conferenceClinical Usefulness of staging Laparoscopy in Patients With Biliary Tract Cancer Following Criteria Based on Inflammation-Based Prognostic Scores and Tumor MarkersPoster presentation
- 第116回日本外科学会定期学術集会, Apr. 2016, Japanese, 日本外科学会, 大阪, Domestic conference多発進行肝癌に対する集学的治療Oral presentation
- 第102回 日本消化器病学会総会, Apr. 2016, English, 日本消化器病学会, 東京, Domestic conference進行多発肝細胞に対する外科治療を機軸とする集学的治療Oral presentation
- 第116回日本外科学会定期学術集会, Apr. 2016, Japanese, 日本外科学会, 大阪, Domestic conference進行肝細胞癌に対する術前化学療法としての経皮的肝灌流化学療法(PHIP)Poster presentation
- 第116回日本外科学会定期学術集会, Apr. 2016, Japanese, 日本外科学会, 大阪, Domestic conference硬変肝を背景とした肝細胞癌に対する肝切除の意義Poster presentation
- 第116回日本外科学会定期学術集会, Apr. 2016, Japanese, 日本外科学会, 大阪, Domestic conference肝臓 移植-1Poster presentation
- ILTS 22nd Annual International Congress, Apr. 2016, English, ILTS, Seoul, International conferenceV5/V8 Hepatic Vein Thrombus after Left Lobe DonationPoster presentation
- 7th International Forum of Liver Surgery, Apr. 2016, English, 7th International Forum of Liver Surgery, Osaka, Japan, International conferenceStrategies to perform hepatectomy without the incidence of posthepatectomy liver failure at Kobe UniversityOral presentation
- The 3rd Yeungnam-Kansai HBP Surgeons Joint Meeting 2016, Apr. 2016, English, KYMeeting, Ulsan, Korea, International conferenceSolid pseudopapillary neoplasms of the pancreas: an experience of nine cases from a single intitutionOral presentation
- ILTS 22nd Annual International Congress, Apr. 2016, English, ILTS, Seoul, International conferenceRole of Contrast-Enhanced Intraoperative Ultrasonic Cholangiography in Living Donor HepatectomyPoster presentation
- ILTS 22nd Annual International Congress, Apr. 2016, English, ILTS, Seoul, International conferenceLow-dose antiviral treatment for hepatitis C virus following living donor liver transplantation without splenectomyPoster presentation
- The 3rd Yeungnam-Kansai HBP Surgeons Joint Meeting 2016, Apr. 2016, English, KYMeeting, Ulsan, Korea, International conferenceLaparoscopic Deroofing of Huge Symptomatic Liver Cysts With Greater Ometum FlapOral presentation
- 7th International Forum of Liver Surgery, Apr. 2016, English, 7th International Forum of Liver Surgery, Osaka, Japan, International conferenceKobe strategy for highly advanced hepatocellilar carcinoma: neoadjuvant percutaneous isolated hepatic perfusion (PIHP) and the following hepatectomyOral presentation
- 7th International Forum of Liver Surgery, Apr. 2016, English, 7th International Forum of Liver Surgery, Osaka, Japan, International conferenceDevelopment of the Biodegradable Surgical Clip Made of a New Magnesium AlloyOral presentation
- The 3rd Yeungnam-Kansai HBP Surgeons Joint Meeting 2016, Apr. 2016, English, KYMeeting, Ulsan, Korea, International conferenceClinical significance of bile reflux into the pancreatic duct without pancreaticobiliary maljunction assessed by intraoperative cholangiographyOral presentation
- 7th International Forum of Liver Surgery, Apr. 2016, English, 7th International Forum of Liver Surgery, Osaka, Japan, International conferenceChemoperfusion therapy with high-dose Cisplatine for malignant liver tumor with extracorporeal drug extraction; a basic study of canine experimental modelOral presentation
- The 3rd Yeungnam-Kansai HBP Surgeons Joint Meeting 2016, Apr. 2016, English, KYMeeting, Ulsan, Korea, International conferenceChange of the Glucose Tolerance after PancreatectomyOral presentation
- 7th International Forum of Liver Surgery, Apr. 2016, English, 7th International Forum of Liver Surgery, Osaka, Japan, International conferenceBaseline plasma chromogranin A levels in patients with well-differentiated neuroendocrine tumors of the pancreas : a potential predictor of postoperative recurrenceOral presentation
- 7th International Forum of Liver Surgery, Apr. 2016, English, 7th International Forum of Liver Surgery, Osaka, Japan, International conferenceA New Technique of Intraoperative Identification of Billary Drainage Areas in Remnant Liver after hepatectomyin Perihilar CholangiocarcinomaOral presentation
- Transplantation Science Symposium(TSS) Asian Regional Meeting, Apr. 2016, English, TSS, Tokyo, International conferenceAnalysis Of Portal Vein Reconstruction Technique With Portal Vein Thrombus with High-grade Portal Vein Thrombus in Living Donor Liver TransplantationPoster presentation
- 第28回日本内視鏡外科学会総会, Dec. 2015, Japanese, 関西医科大学, 大阪, Domestic conference腹腔鏡下尾側膵切除術の安全な術式の定形化Oral presentation
- 第28回日本内視鏡外科学会総会, Dec. 2015, Japanese, 関西医科大学, 大阪, Domestic conference胆道癌に対する審査腹腔鏡の適応についての検討Oral presentation
- 第28回日本内視鏡外科学会総会, Dec. 2015, Japanese, 関西医科大学, 大阪, Domestic conference胆道ジスキネジーに対する単孔式腹腔鏡下胆嚢摘出術Oral presentation
- 第32回近畿肝移植検討会プログラム, Dec. 2015, Japanese, アステラス製薬株式会社, 大阪, Domestic conference一般演題II 座長Others
- 第32回近畿肝移植検討会プログラム, Dec. 2015, Japanese, アステラス製薬株式会社, 大阪, Domestic conference「当科におけるアルコール性肝硬変に対する生体肝移植の検討」Oral presentation
- 第28回日本内視鏡外科学会総会, Dec. 2015, Japanese, 関西医科大学, 大阪, Domestic conferenceソフト凝固とイオアドバンス電極を用いた腹腔鏡下脾温存尾側膵切除術(Lap-SPDP)手技Oral presentation
- Asian Pacific Digestive Week, Dec. 2015, English, 台北, 中国, International conferenceStenotic involvement of the main pancreatic duct is a preoperative predictor of metastases of pancreatic neuroendocrine tumorsOral presentation
- 第77回日本臨床外科学会総会, Nov. 2015, Japanese, 杏林大学, 福岡, Domestic conference膵頭十二指腸切除後に肝内結石症を発生した4例Oral presentation
- 第77回日本臨床外科学会総会, Nov. 2015, Japanese, 杏林大学, 福岡, Domestic conference幽門側胃切除後膵体尾部切除術を施行したStage1膵癌の1例Oral presentation
- 第77回日本臨床外科学会総会, Nov. 2015, Japanese, 杏林大学, 福岡, Domestic conference腹腔鏡下膵切除の現状と将来 腹腔鏡下尾側膵切除における当科の経験Public symposium
- 第15回 Hyogo Liver Conference, Nov. 2015, Japanese, 大塚製薬株式会社, 神戸, Domestic conference特別講演II 司会Others
- 第77回日本臨床外科学会総会, Nov. 2015, Japanese, 杏林大学, 福岡, Domestic conference直腸GIST術後肝外巨大発育をきたしたImatinib耐性肝転移の一切除例Oral presentation
- 第77回日本臨床外科学会総会, Nov. 2015, Japanese, 杏林大学, 福岡, Domestic conference切除肝細胞癌におけるリンパ節転移の検討Oral presentation
- 第77回日本臨床外科学会総会, Nov. 2015, Japanese, 杏林大学, 福岡, Domestic conference高度進行胆嚢癌に対する化学療法後切除の意義Public symposium
- 第77回日本臨床外科学会総会, Nov. 2015, Japanese, 杏林大学, 福岡, Domestic conference原発不明孤立性脾臓腺癌の1例Oral presentation
- 第77回日本臨床外科学会総会, Nov. 2015, Japanese, 杏林大学, 福岡, Domestic conference肝内結石症を背景に発生した胆管内上皮内腫瘍(BilIN-3)の1切除例Oral presentation
- 第77回日本臨床外科学会総会, Nov. 2015, Japanese, 杏林大学, 福岡, Domestic conference肝胆道手術におけるイノベーション:ソナゾイド術中超音波Oral presentation
- 第48回兵庫県内視鏡治療談話会, Nov. 2015, Japanese, アステラス製薬株式会社, 神戸, Domestic conferenceSessionI 神戸大学におけるグラセプター使用例Oral presentation
- American Pancreatic Association 46th Annual Meeting, Nov. 2015, English, カルフォルニア, アメリカ, International conferencePreoperative independent prognostic factors in patients with "resectable" pancreatic adenocarcinoma following curative resection: Neutrophil-lymphocyte ratio and platelet-lymphocyte ratioPoster presentation
- The 2nd International Congress of Living Donor Liver Transplantation Study Group, Nov. 2015, English, ソウル, 韓国, International conferenceA case report of drug-induced thrombocytopenia after living donor liver transplantationPoster presentation
- 日本消化器外科学会大会 JDDW2015, Oct. 2015, Japanese, 日本消化器関連学会機構, 東京, Domestic conference膵中央切除術の短期及び長期成績Poster presentation
- 第51回日本移植学会総会, Oct. 2015, Japanese, 獨協大学, 熊本, Domestic conference膵臓移植後GVHDにおけるHLA 0 mismatchの意義Oral presentation
- 日本消化器外科学会大会 JDDW2015, Oct. 2015, Japanese, 日本消化器関連学会機構, 東京, Domestic conference幽門側胃切除後に膵体尾部切除を施行した膵体尾部癌症例の検討Poster presentation
- 日本消化器外科学会大会 JDDW2015, Oct. 2015, Japanese, 日本消化器関連学会機構, 東京, Domestic conference胆嚢悪性腫瘍と鑑別困難であった胆嚢壁肥厚性病変の検討Poster presentation
- 日本消化器外科学会大会 JDDW2015, Oct. 2015, Japanese, 日本消化器関連学会機構, 東京, Domestic conference大腸癌肝転移に対する肝切除時期についての検討Poster presentation
- 日本消化器外科学会大会 JDDW2015, Oct. 2015, Japanese, 日本消化器関連学会機構, 東京, Domestic conference切除不能胆道癌に対する粒子線治療成績の評価Poster presentation
- 日本消化器外科学会大会 JDDW2015, Oct. 2015, Japanese, 日本消化器関連学会機構, 東京, Domestic conference進行肝癌に対する外科的先進技術を駆使した集学的治療と標準化の課題Oral presentation
- 日本消化器外科学会大会 JDDW2015, Oct. 2015, Japanese, 日本消化器関連学会機構, 東京, Domestic conference高度進行肝内胆管癌に対する治療方針Poster presentation
- 日本消化器外科学会大会 JDDW2015, Oct. 2015, Japanese, 日本消化器関連学会機構, 東京, Domestic conference肝内胆管癌の再発形式から見た手術術式の検討Poster presentation
- 日本肝臓学会大会 JDDW2015, Oct. 2015, Japanese, 日本消化器関連学会機構, 東京, Domestic conference肝切除術における肝生検およびエラストグラフィの現状と課題Public symposium
- 日本消化器外科学会大会 JDDW2015, Oct. 2015, Japanese, 日本消化器関連学会機構, 東京, Domestic conference肝移植後長期経過よりみた肝移植手術成績向上のための課題Public symposium
- 第51回日本移植学会総会, Oct. 2015, Japanese, 獨協大学, 熊本, Domestic conference肝移植医養成における現状と課題Public symposium
- 第51回日本胆道学会学術集会, Sep. 2015, Japanese, 獨協大学, 宇都宮, Domestic conference臨床的T2胆嚢癌の治療成績の検討Poster presentation
- 第51回日本胆道学会学術集会, Sep. 2015, Japanese, 獨協大学, 宇都宮, Domestic conference胆嚢総胆管結石に対する内視鏡的治療後の胆嚢摘出術についての検討Oral presentation
- 第63回日本消化器画像診断研究会, Sep. 2015, Japanese, 横浜市立大学, 鎌倉, Domestic conference術前に分枝型IPMNを疑った膵神経内分泌腫瘍の1例Oral presentation
- 第51回日本胆道学会学術集会, Sep. 2015, Japanese, 獨協大学, 宇都宮, Domestic conference口演32 座長Others
- 第38回日本膵・胆管合流異常研究会, Sep. 2015, Japanese, 新潟大学, 新潟, Domestic conference交通事故による多発外傷を契機にした膵炎で発症した先天性胆道拡張症の1例Oral presentation
- 第51回日本胆道学会学術集会, Sep. 2015, Japanese, 獨協大学, 宇都宮, Domestic conference肝門胆管癌に対する粒子線治療の役割Oral presentation
- 17th Congress of the European Society for Organ Transplantation, Sep. 2015, English, ブリュッセル, ベルギー, International conferencePosterPoster presentation
- 17th Congress of the European Society for Organ Transplantation, Sep. 2015, English, ブリュッセル, ベルギー, International conferenceBrief Oral Session16Oral presentation
- 第24回日本組織適合性学会大会, Sep. 2015, Japanese, 国立病院機構水戸医療センター, 茨城, Domestic conferenceAcute graft-versus-host disease following simultaneous pancreas-kidney transplantation: report of a caseOral presentation
- 第42回日本膵切研究会, Aug. 2015, Japanese, 関西医科大学, 大阪, Domestic conference腹腔鏡下膵体尾部切除における膵切離の工夫Public symposium
- 第42回日本膵切研究会, Aug. 2015, Japanese, 関西医科大学, 大阪, Domestic conference当院におけるR0判定の臨床的意義と問題点Public symposium
- PCCA&IAP 2015, Aug. 2015, English, 上海, 中国, International conferenceStenotic Involvement of the Main Pancreatic Duct is a Preoperative Predictor of Metastases of Pancreatic Neuroendocrine TumorsOral presentation
- PCCA&IAP 2015, Aug. 2015, English, 上海, 中国, International conferenceShort-term and Long-term results of modified Frey’s procedure in patients with chronic pancreatitis: A retrospective single-center study in JapanPoster presentation
- PCCA&IAP 2015, Aug. 2015, English, 上海, 中国, International conferencePrognostic value of serum chromogranin A in pancreatic neuroendocrine tumorsOral presentation
- 14th Congress of the Asian Society of Transplantation, Aug. 2015, English, シンガポール, International conferenceAnalysis Of Portal Vein Reconstruction Technique With Portal Vein ThrombusOral presentation
- 14th Congress of the Asian Society of Transplantation, Aug. 2015, English, シンガポール, International conferenceA Case Of Outflow Block Requiring Metallic Stent Of Inferior Vena Cava And Hepatic Vein After Orthotopic Liver Transplantation Using Piggyback TechniqueOral presentation
- 14th Congress of the Asian Society of Transplantation, Aug. 2015, English, シンガポール, International conferenceA Case Of HCW With Steatohepatitis Early After Liver TransplantationPoster presentation
- 第70回日本消化器外科学会, Jul. 2015, Japanese, 浜松医科大学, 静岡, Domestic conference膵切除後腹腔内出血に対するISGPS-grade分類の評価:当院で経験した35例よりOral presentation
- 第70回日本消化器外科学会, Jul. 2015, Japanese, 浜松医科大学, 静岡, Domestic conference膵神経内分泌腫瘍における血清クロモグラニン値の臨床的有用性Oral presentation
- 第70回日本消化器外科学会, Jul. 2015, Japanese, 浜松医科大学, 静岡, Domestic conference脾悪性リンパ腫と鑑別困難であったため腹腔鏡下脾適術を施行した脾サルコイドーシスの一例Oral presentation
- 第51回日本肝癌研究会, Jul. 2015, Japanese, 神戸大学, 神戸, Domestic conference肉腫様変化を伴った混合型肝癌の一例Poster presentation
- 第51回日本肝癌研究会, Jul. 2015, Japanese, 神戸大学, 神戸, Domestic conference当科における術中Shear Wave Elastgraphy測定Public symposium
- 第70回日本消化器外科学会, Jul. 2015, Japanese, 浜松医科大学, 静岡, Domestic conference当科における系統的切除の考え方と術式選択Oral presentation
- 第70回日本消化器外科学会, Jul. 2015, Japanese, 浜松医科大学, 静岡, Domestic conference超音波胆道造影法を駆使した新たな肝胆道手術ナビゲーション−胆管の描出と胆管ドレナージ領域の把握−Public symposium
- 第70回日本消化器外科学会, Jul. 2015, Japanese, 浜松医科大学, 静岡, Domestic conference胆道癌における試験開腹例の検討Oral presentation
- 第51回日本肝癌研究会, Jul. 2015, Japanese, 神戸大学, 神戸, Domestic conference大腸癌肝転移の肝切除時期についての検討Public symposium
- 第70回日本消化器外科学会, Jul. 2015, Japanese, 浜松医科大学, 静岡, Domestic conference神戸大学における劇症肝炎に対する移植プログラムOral presentation
- 第70回日本消化器外科学会, Jul. 2015, Japanese, 浜松医科大学, 静岡, Domestic conference初回非切除進行胆嚢癌に対する化学療法後の外科切除Oral presentation
- 第70回日本消化器外科学会, Jul. 2015, Japanese, 浜松医科大学, 静岡, Domestic conference胸骨部分正中切開による開縦隔アプローチを用いた高度進行肝癌に対する安全な肝切除術Oral presentation
- 第70回日本消化器外科学会, Jul. 2015, Japanese, 浜松医科大学, 静岡, Domestic conference肝胆膵外科領域における術前膵炎併発例に対する手術手技の工夫Oral presentation
- 第51回日本肝癌研究会, Jul. 2015, Japanese, 神戸大学, 神戸, Domestic conference肝切除の定型化〜リスク低減を目指して〜Public symposium
- 第51回日本肝癌研究会, Jul. 2015, Japanese, 神戸大学, 神戸, Domestic conference肝切除における術中超音波を駆使した新たな胆道ナビゲーションPublic symposium
- 第51回日本肝癌研究会, Jul. 2015, Japanese, 神戸大学, 神戸, Domestic conference肝細胞癌術後の肺.リンパ節・副賢転移に対し集学的治療を行い長期生存を得た1例Poster presentation
- 第37回日本癌局所療法研究会, Jul. 2015, Japanese, 千葉大学, 東京, Domestic conference化学療法が奏効し、切除可能となった多発転移を伴う胆嚢癌の一例Oral presentation
- 第37回日本癌局所療法研究会, Jul. 2015, Japanese, 千葉大学, 東京, Domestic conference胃・結腸・小腸浸潤を伴った浸潤性IPMCに対する1手術例Oral presentation
- 兵庫県消化器外科研究会2015, Jul. 2015, Japanese, 神戸, Domestic conferenceSessionI 座長Others
- 第70回日本消化器外科学会, Jul. 2015, Japanese, 浜松医科大学, 静岡, Domestic conferencePNETに対する治療3 長期生存を得たpNET肝転移の3例Oral presentation
- 第70回日本消化器外科学会, Jul. 2015, English, 浜松医科大学, 静岡, Domestic conferenceNew macroscopic classification of PVTT and back flow thrombectomy for the treatment advanced HCCOral presentation
- 第70回日本消化器外科学会, Jul. 2015, English, 浜松医科大学, 静岡, Domestic conferenceMultidisciplinary therapy for multiple hepatocellurar carcinomaPublic symposium
- 第51回日本肝癌研究会, Jul. 2015, Japanese, 神戸大学, 神戸, Domestic conferenceBCLC intermediate stage肝癌に対す津肝切除例の検討Public symposium
- 第51回日本肝癌研究会, Jul. 2015, Japanese, 神戸大学, 神戸, Domestic conferenceALLPS for extensive liver resection-merit & drawback 司会Others
- 第27回日本肝胆膵外科学会・学術集会, Jun. 2015, Japanese, 東邦大学, 東京, Domestic conference膵癌術前後の耐糖能変化の検討Poster presentation
- 第27回日本肝胆膵外科学会・学術集会, Jun. 2015, Japanese, 東邦大学, 東京, Domestic conference腹腔鏡下直腸前方切除(Lap-AR)から学ぶ腹腔鏡下尾側膵切除(Lap-DP)手技の定型化Oral presentation
- 第27回日本肝胆膵外科学会・学術集会, Jun. 2015, Japanese, 東邦大学, 東京, Domestic conference当施設における腹腔鏡下肝切除の定型化Poster presentation
- 第27回日本肝胆膵外科学会・学術集会, Jun. 2015, Japanese, 東邦大学, 東京, Domestic conference当科における混合型肝癌切除症例20例の検討Poster presentation
- 第27回日本肝胆膵外科学会・学術集会, Jun. 2015, Japanese, 東邦大学, 東京, Domestic conference当科での肝切除の工夫Public symposium
- 第27回日本肝胆膵外科学会・学術集会, Jun. 2015, Japanese, 東邦大学, 東京, Domestic conference著明な胆管内進展を伴った大腸癌肝転移の1例Poster presentation
- 第27回日本肝胆膵外科学会・学術集会, Jun. 2015, Japanese, 東邦大学, 東京, Domestic conference胆道再建術後の肝内結石症の検討Poster presentation
- 第27回日本肝胆膵外科学会・学術集会, Jun. 2015, Japanese, 東邦大学, 東京, Domestic conference神戸大学における脳死肝移植の現状Public symposium
- 第27回日本肝胆膵外科学会・学術集会, Jun. 2015, Japanese, 東邦大学, 東京, Domestic conference肝門部胆管癌手術における術中超音波胆道造影法による胆管ドレナージ領域計測の有用性Public symposium
- 第27回日本肝胆膵外科学会・学術集会, Jun. 2015, Japanese, 東邦大学, 東京, Domestic conference肝門部胆管癌に対する術前肝機能評価と手術成績Poster presentation
- 第27回日本肝胆膵外科学会・学術集会, Jun. 2015, Japanese, 東邦大学, 東京, Domestic conference肝転移、腹膜播種により試験開腹となった胆道癌症例の術前診断に関する検討Poster presentation
- 第27回日本肝胆膵外科学会・学術集会, Jun. 2015, Japanese, 東邦大学, 東京, Domestic conference肝切除後のドレーン留置は必要か?−術後胆汁漏リスク因子からの検討−Public symposium
- 第27回日本肝胆膵外科学会・学術集会, Jun. 2015, Japanese, 東邦大学, 東京, Domestic conference肝上部巨大腫瘍に対する開縦隔アプローチを用いた肝切除Oral presentation
- 第27回日本肝胆膵外科学会・学術集会, Jun. 2015, Japanese, 東邦大学, 東京, Domestic conference肝細胞癌肝切除例における胆汁漏危険因子の検討Poster presentation
- 第46回日本膵臓学会大会, Jun. 2015, Japanese, 愛知県がんセンター中央病院, 名古屋, Domestic conferenceSoft pancreas症例に対する膵空腸再建手術手技Public symposium
- 23rd International congress of the EAES, Jun. 2015, English, ルーマニア, International conferenceComplications after laparoscopic distal pancreatectomyPoster presentation
- 第27回日本肝胆膵外科学会・学術集会, Jun. 2015, Japanese, 東邦大学, 東京, Domestic conferenceBorderline resectable 膵癌の治療成績と今後の対策Poster presentation
- The 3rd Japan-Taiwan Radiation Oncology Symposium, Jun. 2015, English, The 3rd Japan-Taiwan Radiation Oncology Symposium, 山梨, International conferenceA Future Method: Space Modulated Particle Therapy (SMPT) Using a Novel Bioabsorbable SpacerOral presentation
- 第33回日本肝移植研究会, May 2015, Japanese, 神戸大学, 神戸, Domestic conference生体肝移植直後に直腸癌を発症し、吻合部再発と肝転移を併発した1例Oral presentation
- 第33回日本肝移植研究会, May 2015, Japanese, 神戸大学, 神戸, Domestic conference生体肝移植後早期に脂肪性肝炎を呈した1例Public symposium
- 第33回日本肝移植研究会, May 2015, Japanese, 神戸大学, 神戸, Domestic conference神戸大学における劇症肝炎に対する移植プログラムPublic symposium
- 第33回日本肝移植研究会, May 2015, Japanese, 神戸大学, 神戸, Domestic conferenceパネルディスカッション 司会Others
- 第33回日本肝移植研究会, May 2015, Japanese, 神戸大学, 神戸, Domestic conferencePiggyback法を用いた脳死肝移植術後outflow blockに対し下大静脈・肝静脈ステントを挿入した1例Oral presentation
- 15th International Congress of Radiation Research, May 2015, English, 京都, International conferenceNext-stage Bioabsorbable Spacer in Particle TherapyPoster presentation
- 第15回神戸内視鏡外科手術手技研究会, May 2015, Japanese, コヴィディエンジャパン株式会社, 神戸, Domestic conferenceIntermdiate stage以後の肝癌に対する外科的治療成績Public symposium
- 第15回神戸内視鏡外科手術手技研究会, May 2015, Japanese, コヴィディエンジャパン株式会社, 神戸, Domestic conferenceDAAs時代に向けた肝移植後再発C型肝炎に対する低容量インターフェロン療法Public symposium
- 第115回日本外科学会定期学術集会, Apr. 2015, Japanese, 日本外科学会, 名古屋, Domestic conference門脈血栓症を合併したレシピエントに対する門脈再建術の工夫Oral presentation
- 第115回日本外科学会定期学術集会, Apr. 2015, Japanese, 日本外科学会, 名古屋, Domestic conference独自の外科的先進技術を駆使した高度脈管侵襲陽性肝癌に対する治療戦略Public symposium
- 第115回日本外科学会定期学術集会, Apr. 2015, Japanese, 日本外科学会, 名古屋, Domestic conference当施設における女性外科医のリクルートと支援[Invited]Invited oral presentation
- 第115回日本外科学会定期学術集会, Apr. 2015, Japanese, 日本外科学会, 名古屋, Domestic conference胆道癌外瘻例における胆汁返還の免疫能への影響Oral presentation
- 第115回日本外科学会定期学術集会, Apr. 2015, Japanese, 日本外科学会, 名古屋, Domestic conference胆道癌に対する胆道再建術後胆管炎発症例の検討Oral presentation
- 第115回日本外科学会定期学術集会, Apr. 2015, Japanese, 日本外科学会, 名古屋, Domestic conference臓器移植法改正後の急性肝不全に対する肝移植Public symposium
- 第115回日本外科学会定期学術集会, Apr. 2015, Japanese, 日本外科学会, 名古屋, Domestic conference切除可能膵癌に対する治療戦略Public symposium
- 第115回日本外科学会定期学術集会, Apr. 2015, Japanese, 日本外科学会, 名古屋, Domestic conference進行膵癌に対する標準手術のCritical PointOral presentation
- 第115回日本外科学会定期学術集会, Apr. 2015, Japanese, 日本外科学会, 名古屋, Domestic conference術前内視鏡的膵管ステントによる尾側膵切除術後膵液瘻予防効果の前向き臨床試験Oral presentation
- 第115回日本外科学会定期学術集会, Apr. 2015, Japanese, 日本外科学会, 名古屋, Domestic conference術後肝不全を合併しない肝切除術式の選択方法Oral presentation
- 第115回日本外科学会定期学術集会, Apr. 2015, Japanese, 日本外科学会, 名古屋, Domestic conference十二指腸乳頭部癌における取扱い規約第6版の妥当性の検討Oral presentation
- 第115回日本外科学会定期学術集会, Apr. 2015, English, 日本外科学会, 名古屋, Domestic conferencePreoperative independent prognostic factors in patients with borderline resectable pancreatic adenocarcinoma following curative resection:Neutrophil-lymphocyte ratio and platelet-lymphocyte ratioOthers
- Annual Scientific Meeting and Annual General Meeting, Apr. 2015, English, 香港, 中国, International conferenceCurrent strategies to expand donor pool and to improve the outcome of LDLTOral presentation
- 第51回日本腹部救急医学会総会, Mar. 2015, Japanese, 滋賀医科大学、株式会社コングレ, 東京, Domestic conference(司会)生涯忘れられないこの1例 口演03Others
- 第15回京都肝移植周術期研究会, Mar. 2015, Japanese, 京都肝移植周術期研究会・CSLベーリング株式会社, 京都, Domestic conference糖尿病Iaの成人症例に対し脳死肝移植を実施した1例Oral presentation
- 第51回日本腹部救急医学会総会, Mar. 2015, Japanese, 滋賀医科大学、株式会社コングレ, 東京, Domestic conference胆嚢癌減黄治療中に発症した横行結腸浸潤よるイレウスに対し手術を施行した1例Oral presentation
- 第51回日本腹部救急医学会総会, Mar. 2015, Japanese, 滋賀医科大学、株式会社コングレ, 東京, Domestic conference胆道癌術後胆汁瘻発症に関する術前胆管炎の検討Oral presentation
- 神戸肝臓病研究会, Feb. 2015, Japanese, 神戸肝臓病研究会、MSD株式会社, 兵庫, Domestic conference(世話人)神戸肝臓病研究会Others
- 第5回 阪神腫瘍外科学会, Jan. 2015, Japanese, 大鵬薬品工業株式会社, 兵庫, Domestic conference(司会)難問奇問 症例検討Others
- 第31回近畿肝移植検討会プログラム, Dec. 2014, Japanese, 近畿肝移植検討会、アステラス製薬株式会社, 大阪, Domestic conference移植後の管理に難渋したC型肝炎の1例Oral presentation
- 24th World Congress of the IASGO, Dec. 2014, English, IASGO, Vienna, Austria, International conferenceContrast-enhanced intraoperative ultrasonic cholangiography for real-time biliary navigation in hepatobiliary surgeryOral presentation
- 第76回日本臨床外科学会総会, Nov. 2014, Japanese, 日本臨床外科学会, 福島, Domestic conference膵頭十二指腸切除術後在院期間の検討Oral presentation
- 第196回近畿外科学会, Nov. 2014, Japanese, 近畿外科学会, 兵庫, Domestic conference膵体尾部脂肪置換を合併した膵頭部漿液性嚢胞腺腫(SCN)の1切除例Oral presentation
- 第76回日本臨床外科学会総会, Nov. 2014, Japanese, 日本臨床外科学会, 福島, Domestic conference胆嚢摘出術における術中胆道損傷例の検討Oral presentation
- 第76回日本臨床外科学会総会, Nov. 2014, Japanese, 日本臨床外科学会, 福島, Domestic conference組織学的に非典型であった粘液産生胆管腫瘍の一切除例Oral presentation
- 第76回日本臨床外科学会総会, Nov. 2014, Japanese, 日本臨床外科学会, 福島, Domestic conference生体肝移植後胆管狭窄に対し、磁石圧迫吻合術にて狭窄部の開通を得た一例Oral presentation
- 第76回日本臨床外科学会総会, Nov. 2014, Japanese, 日本臨床外科学会, 郡山, Domestic conference抗リン脂質抗体症候群に合併した膵MCNの1手術症例Oral presentation
- 第76回日本臨床外科学会総会, Nov. 2014, Japanese, 日本臨床外科学会, 福島, Domestic conference局所治療後再発性肝癌に対する肝切除Oral presentation
- 第76回日本臨床外科学会総会, Nov. 2014, Japanese, 日本臨床外科学会, 福島, Domestic conference肝外胆管癌における病理学的切除断端陽性例の検討Oral presentation
- 第76回日本臨床外科学会総会, Nov. 2014, Japanese, 日本臨床外科学会, 福島, Domestic conference下大静脈損傷時の止血テクニックPublic symposium
- 第76回日本臨床外科学会総会, Nov. 2014, Japanese, 日本臨床外科学会, 福島, Domestic conferenceソラフェニブ著効により切除可能となった門脈腫瘍栓、下大静脈腫瘍栓、多発肺転移合併進行肝細胞癌の1例Oral presentation
- 45th Meeting of the American Pancreatic Association and Japan Pancreas Society, Nov. 2014, English, APA, Hawaii, USA, International conferencePulmonary embolism after laparoscopic distal pancreatectomy:report of a casePoster presentation
- 45th Meeting of the American Pancreatic Association and Japan Pancreas Society, Nov. 2014, English, APA, Hawaii, USA, International conferencePreoperative independent prognostic facters in patients with borderline resectable pancreatic adenocarcinoma following curative resection:neutrophil-lymphocyte ratio and platelet-lymphocyte ratioPoster presentation
- The 1st International Congress of Living Donor Living Transplantation Study Group(ILDLT), Nov. 2014, English, IDlT, Seoul, Korea, International conferenceLow-dose antiviral treatment for hepatitis C virus following living donor liver transplantation without splenectomyPoster presentation
- 45th Meeting of the American Pancreatic Association and Japan Pancreas Society, Nov. 2014, English, APA, Hawaii, USA, International conferenceA prospective randomized comparison between pylorus-and subtotal stomach-preserving pancreato-duodenectomy on postoperative delayed gastric emptying occurrence and long-term nutritional statusOral presentation
- The 1st International Congress of Living Donor Living Transplantation Study Group(ILDLT), Nov. 2014, English, IDlT, Seoul, Korea, International conferenceA case report of severe post-transplant lymphoproliferative disease after living donor liver transplantationPoster presentation
- The 1st International Congress of Living Donor Living Transplantation Study Group(ILDLT), Nov. 2014, English, IDlT, Seoul, Korea, International conferenceA case report of liver metastasis which was successfully treated by IMRT after LDLTPoster presentation
- JDDW2014 第22回日本消化器関連学会週間, Oct. 2014, Japanese, 日本消化器関連学会機構, 兵庫, Domestic conference(座長)デジタルポスターセッションOthers
- 第27回日本内視鏡外科学会総会, Oct. 2014, Japanese, 日本内視鏡外科学会, 岩手, Domestic conference膵内視鏡外科の安全性と効率化 腹腔鏡下尾側膵切除術における当科の経験Oral presentation
- JDDW2014 第22回日本消化器関連学会週間, Oct. 2014, Japanese, 日本消化器関連学会機構, 兵庫, Domestic conference膵神経内分泌腫瘍における主膵管変化はリンパ節転移の予後因子であるPoster presentation
- JDDW2014 第22回日本消化器関連学会週間, Oct. 2014, Japanese, 日本消化器関連学会機構, 兵庫, Domestic conference膵癌術前予後予測因子としてのFDG-PET SUVmaxの有用性Poster presentation
- 第9回膵癌術前治療研究会, Oct. 2014, Japanese, 鹿児島大学, 鹿児島, Domestic conference膵癌術前治療PR症例に対するR0手術後3カ月で局所再発をきたした1例Poster presentation
- 第27回日本内視鏡外科学会総会, Oct. 2014, Japanese, 日本内視鏡外科学会, 岩手, Domestic conference腹腔鏡下尾側膵切除術ー導入から術式の定型化・技術認定医取得までーOral presentation
- 第27回日本内視鏡外科学会総会, Oct. 2014, Japanese, 日本内視鏡外科学会, 岩手, Domestic conference胆道癌に対する審査腹腔鏡の有用性Public symposium
- JDDW2014 第22回日本消化器関連学会週間, Oct. 2014, Japanese, 日本消化器関連学会機構, 兵庫, Domestic conference大腸癌肝転移に対する初回肝切除後の予後因子の検討Poster presentation
- 第27回日本内視鏡外科学会総会, Oct. 2014, Japanese, 日本内視鏡外科学会, 岩手, Domestic conference切除可否の判定に審査腹腔鏡が有用であった化学療法著効後の進行胆嚢癌の一例Oral presentation
- JDDW2014 第22回日本消化器関連学会週間, Oct. 2014, Japanese, 日本消化器関連学会機構, 兵庫, Domestic conference進行肝癌に対する独自の外科的先端技術を駆使した集学的治療Public symposium
- 第2回神緑会ヤングインベスティゲーターアワード発表会, Oct. 2014, Japanese, 神戸大学, 兵庫, Domestic conference術中超音波を駆使した新しい肝胆道手術ナビゲーション技術の開発Oral presentation
- JDDW2014 第22回日本消化器関連学会週間, Oct. 2014, Japanese, 日本消化器関連学会機構, 兵庫, Domestic conference肝門部胆管癌における胆管進展範囲同定のための3D-CT胆管構築像の評価Poster presentation
- JDDW2014 第22回日本消化器関連学会週間, Oct. 2014, Japanese, 日本消化器関連学会機構, 兵庫, Domestic conference肝切除における術前シュミレーションと術中ナビゲーションPublic symposium
- JDDW2014 第22回日本消化器関連学会週間, Oct. 2014, Japanese, 日本消化器関連学会機構, 兵庫, Domestic conference肝外胆管癌に対する胆管切除術の有用性の検討Poster presentation
- JDDW2014 第22回日本消化器関連学会週間, Oct. 2014, Japanese, 日本消化器関連学会機構, 兵庫, Domestic conference肝移植後長期生着を目指してPoster presentation
- 第6回膵臓内視鏡外科研究会, Oct. 2014, Japanese, 東京慈恵会医科大学, 岩手, Domestic conference一般消化器外科医のための腹腔鏡下膵体尾部切除入門「Lap-ARから学ぶLap-DP」Oral presentation
- JDDW2014 第22回日本消化器関連学会週間, Oct. 2014, Japanese, 日本消化器関連学会機構, 兵庫, Domestic conferenceNBNC肝細胞癌に対する外科切除症例の検討Public symposium
- JDDW2014 第22回日本消化器関連学会週間, Oct. 2014, English, 日本消化器関連学会機構, 兵庫, Domestic conferenceFibrotic liver regeneration after hepatectomy. How faw can we perform hepatectomy for HCC patients with fibrosis?Public symposium
- MMND & IPCT 2014, Oct. 2014, English, University of Wollo0ngong, Port Douglas, Australia, International conferenceEfficacy of PGA Spacer in Particle Therapy: A novel strategy Making Temporal Space between Tumor and Adjacent Organs[Invited]Invited oral presentation
- 第50回日本胆道学会学術集会, Sep. 2014, Japanese, 日本胆道学会, 東京, Domestic conference膵胆管合流異常症に合併した脈管破格に関する検討Poster presentation
- 第50回日本移植学会総会, Sep. 2014, Japanese, 日本移植学会, 東京, Domestic conference膵腎同時移植後グラフト十二指腸穿孔を生じた1例Poster presentation
- 第37回日本膵・胆管合流異常研究会, Sep. 2014, Japanese, 横浜市立大学, 神奈川, Domestic conference膵・胆管合流異常症に伴う腹部血管破格についての検討Oral presentation
- 第50回日本胆道学会学術集会, Sep. 2014, Japanese, 日本胆道学会, 東京, Domestic conference胆道癌切除例における術前胆汁返還の周術期合併症への効果Poster presentation
- 第50回日本移植学会総会, Sep. 2014, Japanese, 日本移植学会, 東京, Domestic conference神戸大学における劇症肝炎に対する移植プログラムPoster presentation
- 第17回近畿外科病態研究会, Sep. 2014, Japanese, 近畿外科病態研究会、CSLベーリング株式会社, 大阪, Domestic conference抗凝固療法、抗血小板療法施行患者における肝胆膵外科手術の術後出血、血栓症のリスクについてOral presentation
- 第50回日本胆道学会学術集会, Sep. 2014, Japanese, 日本胆道学会, 東京, Domestic conference肝転移を伴った大腸癌に対して長期間の化学療法後に手術を施行した肝門部胆管癌の1例Poster presentation
- 第9回肝癌治療シュミレーション研究会, Sep. 2014, Japanese, 関西医科大学, 大阪, Domestic conference肝切除・肝移植術における胆道シュミレーションと胆道ナビゲーションー胆管フュージョン画像と超音波胆道造影の活用ーOral presentation
- 第50回日本胆道学会学術集会, Sep. 2014, Japanese, 日本胆道学会, 東京, Domestic conference肝外肝管癌における術中迅速診断の役割Poster presentation
- 第15回兵庫県臓器提供懇話会, Sep. 2014, Japanese, 兵庫県健康福祉部健康局, 兵庫, Domestic conference『兵庫県における肝移植の現状』Oral presentation
- The 10th Japan-Korea Transplantation Forum, Sep. 2014, English, Youson KuShiro Takahara, Tokyo, Japan, International conferenceSuccessful treatment of fibrosing cholestatic hepatitis following liver transplantation with simeprevir, peginterferon and ribavirin for a pre-transplant null-responderPoster presentation
- Mongolia Japanese joint VI Symposium, Sep. 2014, English, 不明, Ulanbator, Mongol, International conferencePreoperative independent prognostic factors in patients with borderline resectable pancreatic adenocarcinoma following curative resection : neutrophil-lymphocyte ratio and platelet-lymphocyte ratio.Oral presentation
- The 10th Japan-Korea Transplantation Forum, Sep. 2014, English, Youson KuShiro Takahara, Tokyo, Japan, International conferencePancreatoduodenectomy after kidney transplantation : report of a casePoster presentation
- The 15th Asian Oceanian Congress of Radiology AOCR 2014, Sep. 2014, English, Asia Oceania Congress of Radiology, Kobe, International conferenceA Novel Method for Space Modulated Radiotherapy (SMRT):Nonwoven fabric polyglycolic acid (PGA) spacerPoster presentation
- 第52回日本癌治療学会学術集会, Aug. 2014, Japanese, 日本癌治療学会, 神奈川, Domestic conference膵癌術前予後予測因子としてのFDG-PETの有用性Oral presentation
- 第41回日本膵切研究会, Aug. 2014, Japanese, 東京歯科大学, 東京, Domestic conference幽門輪温存膵頭十二指腸切除術(PPPD)と亜全胃温存膵頭十二指腸切除術(SSPPD)の短期・長期成績の前向き比較試験Poster presentation
- 第41回日本膵切研究会, Aug. 2014, Japanese, 東京歯科大学, 東京, Domestic conference腹腔鏡下尾側膵切除術の定型化と今後の展望Oral presentation
- 第52回日本癌治療学会学術集会, Aug. 2014, Japanese, 日本癌治療学会, 神奈川, Domestic conference進行胆道癌に対する塩酸ゲムシタビンによる術後補助療法の成績Oral presentation
- 6th International Forum of Liver Surgery, Aug. 2014, English, Japanese German Sciety for the Study of Liver Surgery, Hamgurg,Wilsede, Germany, International conferenceSurgical trial with chemoperfusion therapy for initially unresectable hepatocellular carcinomaOral presentation
- 6th International Forum of Liver Surgery, Aug. 2014, English, Japanese German Sciety for the Study of Liver Surgery, Hamgurg,Wilsede, Germany, International conferenceMacroscopic classification of PVTT and Back flow thrombectomy for the treatment of advanced HCC with Vp4 PVTTOral presentation
- Daegu-Kansai HBP Surgeons Joint Meeting 2014, Aug. 2014, English, Yeungnam University, Gyeongsan, Korea, International conferenceInvestigation about resected cases of carcinoma of papilla Vater according to the degree of progree of progressionOral presentation
- Daegu-Kansai HBP Surgeons Joint Meeting 2014, Aug. 2014, English, Yeungnam University, Gyeongsan, Korea, International conferenceDual treatment of reductive surgery and sequential percutaneous isolated hepatic perfusion for multiple bilobar hepatocellular carcinomaOral presentation
- 6th International Forum of Liver Surgery, Aug. 2014, English, Japanese German Sciety for the Study of Liver Surgery, Hamgurg,Wilsede, Germany, International conferenceContract-enhanced intraoperative ultrasonic cholangiography for real-time biliary navigation in hepatobiliary surgeryOral presentation
- Daegu-Kansai HBP Surgeons Joint Meeting 2014, Aug. 2014, English, Yeungnam University, Gyeongsan, Korea, International conferenceComparison of postoperative glucose tolerance between pancreaticoduodenectomy and distal pancreatectomyOral presentation
- 第32回日本肝移植研究会, Jul. 2014, Japanese, 順天堂大学, 東京, Domestic conference(司会)周術期管理,合併症3Others
- 第14回関西肝血流動態・機能イメージ研究会, Jul. 2014, Japanese, エーザイ株式会社, 大阪, Domestic conference(コメンテーター)一般演題Others
- 第69回日本消化器外科学会総会, Jul. 2014, Japanese, 日本消化器病学会, 福島, Domestic conference膵頭十二指腸切除術における切離、吻合の工夫ー安全・確実な膵空腸再健手術手技ーKeynote oral presentation
- 第45回日本肝臓学会大会, Jul. 2014, Japanese, 日本膵臓学会, 福岡, Domestic conference膵癌切除後早期再発の危険因子と予測スコアPublic symposium
- 第69回日本消化器外科学会総会, Jul. 2014, Japanese, 日本消化器病学会, 福島, Domestic conference膵癌術後長期無再発生存例の検討Oral presentation
- 第69回日本消化器外科学会総会, Jul. 2014, Japanese, 日本消化器病学会, 福島, Domestic conference胆道癌周術期感染症と術前胆道ドレナージの関連性の検討Keynote oral presentation
- 第69回日本消化器外科学会総会, Jul. 2014, Japanese, 日本消化器病学会, 福島, Domestic conference胆道癌根治切除例における術前減黄中胆管炎・膵炎発生の治療成績への影響Oral presentation
- 第69回日本消化器外科学会総会, Jul. 2014, Japanese, 日本消化器病学会, 福島, Domestic conference大腸癌肝転移に対する肝切除後の予後因子の検討Oral presentation
- 第69回日本消化器外科学会総会, Jul. 2014, Japanese, 日本消化器病学会, 福島, Domestic conference体内空間可変粒子線治療による肝胆膵癌の治療Keynote oral presentation
- 第45回日本肝臓学会大会, Jul. 2014, Japanese, 日本膵臓学会, 福岡, Domestic conference切離部位に着目した腹腔鏡下尾側膵切除術の要点Oral presentation
- 第32回日本肝移植研究会, Jul. 2014, Japanese, 順天堂大学, 東京, Domestic conference生体肝移植後に直腸癌を発症し、術後肝転移と吻合部再発を併発した1例Oral presentation
- 第69回日本消化器外科学会総会, Jul. 2014, Japanese, 日本消化器病学会, 福島, Domestic conference進行肝細胞癌に対するPIHPを軸とした集学的治療Oral presentation
- 第32回日本肝移植研究会, Jul. 2014, Japanese, 順天堂大学, 東京, Domestic conference神戸大学における劇症肝炎に対する移植プログラムOral presentation
- 第69回日本消化器外科学会総会, Jul. 2014, Japanese, 日本消化器病学会, 福島, Domestic conference術前・術中肝生検を反映した新たな肝切除術式の立案Public symposium
- 第69回日本消化器外科学会総会, Jul. 2014, Japanese, 日本消化器病学会, 福島, Domestic conference腫瘍数4個以上の進行多発肝細胞癌に対する肝切除の意義Public symposium
- 第69回日本消化器外科学会総会, Jul. 2014, Japanese, 日本消化器病学会, 福島, Domestic conference広範囲胆管癌に対する治療法別(切除、化学療法、粒子線)の成績Public symposium
- 第69回日本消化器外科学会総会, Jul. 2014, Japanese, 日本消化器病学会, 福島, Domestic conference好中球/リンパ球比はBorderline resectable 膵癌根治切除例に対する予後予測因子として有用であるKeynote oral presentation
- 第69回日本消化器外科学会総会, Jul. 2014, Japanese, 日本消化器病学会, 福島, Domestic conference巨大肝癌に対する肝切除のknack&pitfallPublic symposium
- 第69回日本消化器外科学会総会, Jul. 2014, Japanese, 日本消化器病学会, 福島, Domestic conference肝内胆管癌切除後再発に対する治療方針の検討Oral presentation
- 第45回日本肝臓学会大会, Jul. 2014, Japanese, 日本膵臓学会, 福岡, Domestic conferenceStage0/I 膵癌切除症例の検討Oral presentation
- World Transplant Congress 2014, Jul. 2014, English, WTC, San Francisco, USA, International conferenceLeakage from distal oversewn end of the duodenum-graft in simultaneous pancreas-kidney transplants:report of a caseOral presentation
- World Transplant Congress 2014, Jul. 2014, English, WTC, San Francisco, USA, International conferenceGraft type significantly associates with the incidence of posthepatectomy liver failure defined by ISGLS in living donorsOral presentation
- 第36回日本癌局所療法研究会, Jun. 2014, Japanese, 八尾市立病院, 大阪, Domestic conference(座長)主題II —2Others
- 第26回日本肝胆膵外科学会・学術集会, Jun. 2014, Japanese, 日本肝胆膵外科学会, 和歌山, Domestic conference膵頭部領域悪性腫瘍患者6例に発生した重症急性膵炎後の膵頭十二指腸切除術の周術期管理についてPoster presentation
- 第26回日本肝胆膵外科学会・学術集会, Jun. 2014, Japanese, 日本肝胆膵外科学会, 和歌山, Domestic conference膵頭十二指腸切除と尾側膵切除の術後耐糖能の比較検討Poster presentation
- 第26回日本肝胆膵外科学会・学術集会, Jun. 2014, Japanese, 日本肝胆膵外科学会, 和歌山, Domestic conference膵切除における手術手技の工夫 生食滴下式バイポーラを用いた手術手技Poster presentation
- 第36回日本癌局所療法研究会, Jun. 2014, Japanese, 八尾市立病院, 大阪, Domestic conference膵癌術後の左側門脈圧亢進症に対しHassab手術が有効であった1例Oral presentation
- 第36回日本癌局所療法研究会, Jun. 2014, Japanese, 八尾市立病院, 大阪, Domestic conference粒子線治療後に再発した転移性肝癌の一切除例Oral presentation
- 第50回日本肝癌研究会, Jun. 2014, Japanese, 日本肝癌研究会, 京都, Domestic conference独自の外科的先進技術を駆使した進行・大型肝癌に対する治療戦略Public symposium
- 第50回日本肝癌研究会, Jun. 2014, Japanese, 日本肝癌研究会, 京都, Domestic conference当科における混合型肝癌切除例の臨床病理学的検討Public symposium
- 第36回日本癌局所療法研究会, Jun. 2014, Japanese, 八尾市立病院, 大阪, Domestic conference腸骨転移を伴う肝細胞癌に対し集学的治療で長期生存を得た一例Oral presentation
- 第26回日本肝胆膵外科学会・学術集会, Jun. 2014, Japanese, 日本肝胆膵外科学会, 和歌山, Domestic conference胆道癌切除例における胆道再健の工夫Poster presentation
- 第26回日本肝胆膵外科学会・学術集会, Jun. 2014, Japanese, 日本肝胆膵外科学会, 和歌山, Domestic conference胆道癌切除後胆汁瘻の危険因子と治療Oral presentation
- 第50回日本肝癌研究会, Jun. 2014, Japanese, 日本肝癌研究会, 京都, Domestic conference大腸癌肝転移に対する肝切除後の予後因子の検討Oral presentation
- 第26回日本肝胆膵外科学会・学術集会, Jun. 2014, Japanese, 日本肝胆膵外科学会, 和歌山, Domestic conference生体肝移植ドナー肝切除手術における術中超音波胆道造影法Public symposium
- 第26回日本肝胆膵外科学会・学術集会, Jun. 2014, Japanese, 日本肝胆膵外科学会, 和歌山, Domestic conference進行度からみた十二指腸乳頭部癌切除例の検討Poster presentation
- 第26回日本肝胆膵外科学会・学術集会, Jun. 2014, Japanese, 日本肝胆膵外科学会, 和歌山, Domestic conference術前診断が困難であった膵内副脾Epidermoid cystの1例Poster presentation
- 第26回日本肝胆膵外科学会・学術集会, Jun. 2014, Japanese, 日本肝胆膵外科学会, 和歌山, Domestic conference術前診断が困難であった膵頭部IPMCの1例Poster presentation
- 第36回日本癌局所療法研究会, Jun. 2014, Japanese, 八尾市立病院, 大阪, Domestic conference硬化性胆管炎合併胆管癌に化学療法を行い長期生存した1例Oral presentation
- 第22回神戸胆道疾患研究会, Jun. 2014, Japanese, 第一三共株式会社, 兵庫, Domestic conference肝門部悪性胆道狭窄に対する術前胆管炎発症例の検討Oral presentation
- 第26回日本肝胆膵外科学会・学術集会, Jun. 2014, Japanese, 日本肝胆膵外科学会, 和歌山, Domestic conference肝内胆管癌切除例における切離断端陽性リスクの検討Poster presentation
- 第36回日本癌局所療法研究会, Jun. 2014, Japanese, 八尾市立病院, 大阪, Domestic conference肝内胆管癌再発例に対する再切除の可能性Oral presentation
- 第50回日本肝癌研究会, Jun. 2014, Japanese, 日本肝癌研究会, 京都, Domestic conference肝内胆管癌再発形式から見た至適術式Public symposium
- 第26回日本肝胆膵外科学会・学術集会, Jun. 2014, Japanese, 日本肝胆膵外科学会, 和歌山, Domestic conference肝切除における当科の術前シュミレーションの現状Poster presentation
- 第50回日本肝癌研究会, Jun. 2014, Japanese, 日本肝癌研究会, 京都, Domestic conference肝細胞癌切除後再発に対しsorafenibを含む集学的治療を行い長期生存を得た2例Oral presentation
- 第26回日本肝胆膵外科学会・学術集会, Jun. 2014, Japanese, 日本肝胆膵外科学会, 和歌山, Domestic conference肝細胞癌に対する初回肝切除例のおける胆汁漏危険因子の解析Poster presentation
- 第50回日本肝癌研究会, Jun. 2014, Japanese, 日本肝癌研究会, 京都, Domestic conference肝細胞癌に対する肝切除における術前シュミレーションと術中ナビゲーションPublic symposium
- 第26回日本肝胆膵外科学会・学術集会, Jun. 2014, Japanese, 日本肝胆膵外科学会, 和歌山, Domestic conference黄色肉芽腫性胆嚢炎切除後に遺残胆嚢癌を発症した1例Poster presentation
- 第50回日本肝癌研究会, Jun. 2014, Japanese, 日本肝癌研究会, 京都, Domestic conferenceラジオ波焼灼療法後再発肝癌に対する肝切除術Public symposium
- 第26回日本肝胆膵外科学会・学術集会, Jun. 2014, Japanese, 日本肝胆膵外科学会, 和歌山, Domestic conferenceポスターセッション81 肝臓・腫瘍5Others
- 第26回日本肝胆膵外科学会・学術集会, Jun. 2014, Japanese, 日本肝胆膵外科学会, 和歌山, Domestic conferenceVp4門脈腫瘍栓合併肝癌に対するBack Flow Thrombectomy法と経皮的肝灌流化学療法を用いた外科的治療戦略Public symposium
- 第26回日本肝胆膵外科学会・学術集会, Jun. 2014, Japanese, 日本肝胆膵外科学会, 和歌山, Domestic conferencevp1肝細胞癌の術後再発についての検討Poster presentation
- 14th World Congress of Endoscopic Surgery (EAES), Jun. 2014, English, EAES, Paris, France, International conferenceThe original devices of laparoscopic liver surgery in our institutionOral presentation
- 第26回日本肝胆膵外科学会・学術集会, Jun. 2014, Japanese, 日本肝胆膵外科学会, 和歌山, Domestic conferenceT2胆嚢癌の治療成績の検討Oral presentation
- 第36回日本癌局所療法研究会, Jun. 2014, Japanese, 八尾市立病院, 大阪, Domestic conferenceS-1が著効しR0切除し得た局所進行切除不能膵癌の1例Oral presentation
- 4th International Kyoto Liver Cancer Symposium (IKLS), Jun. 2014, English, Kinki University, Kyoto, Japan, International conferenceReductive hepatectomy with percutaneous isolated hepatic perfusion as the first-line treatment for hepatocellular carcinoma with multiple bilobar lesions[Invited]Invited oral presentation
- 第50回日本肝癌研究会, Jun. 2014, Japanese, 日本肝癌研究会, 京都, Domestic conferenceIntermediateおよびAdvanced Stageに対する外科切除を中心とする集学的治療Public symposium
- 14th World Congress of Endoscopic Surgery (EAES), Jun. 2014, English, EAES, Paris, France, International conferenceA novel and safe method for retraction of the liver and the stomachdring laparoscopic distal pancreatectomyOral presentation
- 第50回日本肝臓学会総会, May 2014, Japanese, 日本肝臓学会, 東京, Domestic conference摘出肝線維化の術前評価方法Oral presentation
- 神戸大学消化器外科最新手術セミナー, May 2014, Japanese, ミヤリサン製薬, 兵庫, Domestic conference第2部 肝胆膵領域Others
- 第50回日本肝臓学会総会, May 2014, Japanese, 日本肝臓学会, 東京, Domestic conference走査型蛍光X線顕微鏡を用いたC型肝炎における肝組織内鉄分布の解析Public symposium
- 第195回近畿外科学会, May 2014, Japanese, 近畿外科学会, 大阪, Domestic conference腎細胞癌胆嚢転移の1切除例Oral presentation
- 第68回手術手技研究会, May 2014, Japanese, 近畿大学, 東京, Domestic conference神戸大学の再発肝癌に対する外科治療戦略:その適応と限界Oral presentation
- 第50回日本肝臓学会総会, May 2014, Japanese, 日本肝臓学会, 東京, Domestic conference県内の肝疾患診療連携体制における当施設の役割Public symposium
- 第68回手術手技研究会, May 2014, Japanese, 近畿大学, 東京, Domestic conferenceグラフト肝動脈血流の最大化を目指した脳死全肝移植術Oral presentation
- 第87回日本消化器内視鏡学会総会, May 2014, Japanese, 九州大学, 福岡, Domestic conferenceERCP後重症急性膵炎後の膵頭十二指腸切除術例の検討Oral presentation
- 第114回日本外科学会定期学術集会, Apr. 2014, Japanese, 日本外科学会, 京都, Domestic conference膵頭十二指腸切除が膵内分泌機能に及ぼす影響についてPoster presentation
- 第114回日本外科学会定期学術集会, Apr. 2014, Japanese, 日本外科学会, 京都, Domestic conference膵切除術における周術期管理Oral presentation
- 第114回日本外科学会定期学術集会, Apr. 2014, Japanese, 日本外科学会, 京都, Domestic conference膵神経内分泌腫瘍(PNET)の転移に関わる因子の検討Oral presentation
- 第100回日本消化器病学会総会, Apr. 2014, Japanese, 日本消化器病学会, 東京, Domestic conference膵癌術後補助化学療法の完遂予測因子の検討Oral presentation
- 第100回日本消化器病学会総会, Apr. 2014, Japanese, 日本消化器病学会, 東京, Domestic conference膵癌との鑑別を要した自己免疫性膵炎の検討:外科医が経験した9例Oral presentation
- 第114回日本外科学会定期学術集会, Apr. 2014, Japanese, 日本外科学会, 京都, Domestic conference良低悪性度腫瘍に対する腹腔鏡下膵体尾部切除術Poster presentation
- 第114回日本外科学会定期学術集会, Apr. 2014, Japanese, 日本外科学会, 京都, Domestic conference末期肝硬変患者における副腎機能評価の検討Poster presentation
- 第114回日本外科学会定期学術集会, Apr. 2014, Japanese, 日本外科学会, 京都, Domestic conference閉塞性黄疸手術例に対する外瘻胆汁返還中の全身・腸管免疫能の動態の解析Oral presentation
- 第100回日本消化器病学会総会, Apr. 2014, Japanese, 日本消化器病学会, 東京, Domestic conference非切除進行、再発胆道癌に対するGEM,S-1段階的治療の成績Oral presentation
- 第114回日本外科学会定期学術集会, Apr. 2014, Japanese, 日本外科学会, 京都, Domestic conference地域医療循環型人材育成プログラムを用いた神戸大学と兵庫県の地域外科医療連携-兵庫県立柏原病院での実践 -Keynote oral presentation
- 第114回日本外科学会定期学術集会, Apr. 2014, Japanese, 日本外科学会, 京都, Domestic conference進行多発肝細胞癌に対する外科治療の役割Poster presentation
- 第100回日本消化器病学会総会, Apr. 2014, Japanese, 日本消化器病学会, 東京, Domestic conference進行肝癌に対するPIHPを基軸とした治療戦略:2段階治療と3段階治療Public symposium
- 第114回日本外科学会定期学術集会, Apr. 2014, Japanese, 日本外科学会, 京都, Domestic conference神戸大学におけるポジティブアクションプログラムOral presentation
- 第114回日本外科学会定期学術集会, Apr. 2014, Japanese, 日本外科学会, 京都, Domestic conference新臨床研修制度導入後の外科医育成の取り組みPoster presentation
- 第100回日本消化器病学会総会, Apr. 2014, Japanese, 日本消化器病学会, 東京, Domestic conference女性外科医の獲得と支援に向けた提言Oral presentation
- 第114回日本外科学会定期学術集会, Apr. 2014, Japanese, 日本外科学会, 京都, Domestic conference十二指腸乳頭部癌術後早期合併症の検討Poster presentation
- 第114回日本外科学会定期学術集会, Apr. 2014, Japanese, 日本外科学会, 京都, Domestic conference腫瘍栓合併肝静脈根部大型肝癌に対する外科治療Public symposium
- 第100回日本消化器病学会総会, Apr. 2014, Japanese, 日本消化器病学会, 東京, Domestic conference経乳頭的胆囊胆汁細胞診の検討Oral presentation
- 第100回日本消化器病学会総会, Apr. 2014, Japanese, 日本消化器病学会, 東京, Domestic conference肝移植後長期生着を目指してOral presentation
- 第114回日本外科学会定期学術集会, Apr. 2014, Japanese, 一般社団法人日本外科学会, 京都, Domestic conference胃癌肝転移に対する化学療法および手術療法の成績からみた治療戦略Poster presentation
- European Society for Radiotherapy & Oncology 33, Apr. 2014, English, European Society for Radiotherapy & Oncology, Vienna, International conferenceIntra-abdomical space modulated radiotherapy: Safety and efficacy of absorbable spacer in particle therapyPoster presentation
- 第18回兵庫粒子線治療研究会, Mar. 2014, Japanese, 兵庫粒子線治療研究会, 兵庫(神戸大学医学部附属病院), Domestic conference腹部・骨盤部悪性腫瘍に対する体内空間可変粒子線治療の治療成績Oral presentation
- The 86th Annual Meeting of Japanese Gastric Association, Mar. 2014, Japanese, Meeting of Japanese Gastric Association, 横浜, Domestic conference胃癌肝転移に対する治療戦略-肝切除の意義と役割-Oral presentation
- 第26回日本内視鏡外科学会, Nov. 2013, Japanese, 日本内視鏡外科学会, 福岡, Domestic conference腹腔鏡下尾側膵切除術 術式の定型化と技術認定医をめざしてPublic symposium
- 第5回膵臓内視鏡外科学会, Nov. 2013, Japanese, 膵臓内視鏡外科学会, 福岡, Domestic conference腹腔鏡下尾側膵切除術の手技と成績Oral presentation
- 第26回日本内視鏡外科学会, Nov. 2013, Japanese, 日本内視鏡外科学会, 福岡, Domestic conference腹腔鏡下尾側膵切除術におけるシリコンディスクを用いた胃・肝圧排法Oral presentation
- 第75回日本臨床外科学会, Nov. 2013, Japanese, 日本臨床外科学会, 名古屋, Domestic conference内視鏡下虫垂切除術の手術手技Others
- 第75回日本臨床外科学会, Nov. 2013, Japanese, 日本臨床外科学会, 名古屋, Domestic conference同時性胆道重複癌の検討Others
- 第75回日本臨床外科学会, Nov. 2013, Japanese, 日本臨床外科学会, 名古屋, Domestic conference当施設における外科医リクルート策略Others
- 第26回日本内視鏡外科学会, Nov. 2013, Japanese, 日本内視鏡外科学会, 福岡, Domestic conference当科における腹腔鏡下肝切除の工夫Others
- 第26回日本内視鏡外科学会, Nov. 2013, Japanese, 日本内視鏡外科学会, 福岡, Domestic conference胆嚢摘出時の術中胆道造影における胆汁膵管逆流現象の臨床的意義Oral presentation
- 第75回日本臨床外科学会, Nov. 2013, Japanese, 日本臨床外科学会, 名古屋, Domestic conference臓器移植法改正後の肝移植の現況Public symposium
- 第75回日本臨床外科学会, Nov. 2013, Japanese, 日本臨床外科学会, 名古屋, Domestic conference進行肝細胞癌に対する術前化学療法としてのPIHP(経皮的肝灌流)の安全性と有用性の検討Public symposium
- 第75回日本臨床外科学会, Nov. 2013, Japanese, 日本臨床外科学会, 名古屋, Domestic conference術前胆道ドレナージ症例における術後胆管炎の検討Others
- 第75回日本臨床外科学会, Nov. 2013, Japanese, 日本臨床外科学会, 名古屋, Domestic conference主膵管との交通を認め術前診断が困難であった膵粘液性嚢胞腫瘍(MCN)の1切除例Others
- 第75回日本臨床外科学会, Nov. 2013, Japanese, 日本臨床外科学会, 名古屋, Domestic conference残膵癌に対する治療戦略Public symposium
- 第75回日本臨床外科学会, Nov. 2013, Japanese, 日本臨床外科学会, 名古屋, Domestic conference肝門部胆管癌におけるRO切除と術後補助化学療法の意義Oral presentation
- 第26回日本内視鏡外科学会, Nov. 2013, Japanese, 日本内視鏡外科学会, 福岡, Domestic conference肝嚢胞に対する腹腔鏡下開窓術Oral presentation
- 第75回日本臨床外科学会, Nov. 2013, Japanese, 日本臨床外科学会, 名古屋, Domestic conference肝内結石症長期観察中に発生した広範な肝内胆管癌に一切除例Others
- 第75回日本臨床外科学会, Nov. 2013, Japanese, 日本臨床外科学会, 名古屋, Domestic conference肝切除後に肝鎌状間膜内再発を来した肝細胞癌の一例Oral presentation
- 第75回日本臨床外科学会, Nov. 2013, Japanese, 日本臨床外科学会, 名古屋, Domestic conferenceリンパ節転移を伴った腫瘍径14mmの非機能性膵内分泌腫瘍の1例Oral presentation
- AMERICAN ASSOCIATION FOR THE STUDY OF LIVER DISEASES(The Living Meeting 2017), Nov. 2013, English, AMERICAN ASSOCIATION FOR THE STUDY OF LIVER DISEASES, Washington, USA, International conferenceUsefulness of 99mTc-GSA scintigraphy on preoperative evaluation of liver function for hepatectomyPoster presentation
- AMERICAN ASSOCIATION FOR THE STUDY OF LIVER DISEASES(The Living Meeting 2015), Nov. 2013, English, AMERICAN ASSOCIATION FOR THE STUDY OF LIVER DISEASES, Washington, USA, International conferenceGraft Type Significantly Associates with the Incidence of Posthepatectomy Liver Failure Defined by ISGLS in Living Donors after HepatectomyPoster presentation
- AMERICAN ASSOCIATION FOR THE STUDY OF LIVER DISEASES(The Living Meeting 2014), Nov. 2013, English, AMERICAN ASSOCIATION FOR THE STUDY OF LIVER DISEASES, Washington, USA, International conferenceDual Treatment; A Novel Strategy for Highly-Adovanced Hepatocellular carcinomaPublic symposium
- 第75回日本臨床外科学会, Nov. 2013, Japanese, 日本臨床外科学会, 名古屋, Domestic conferenceDenver型腹腔静脈シャント留置後に発症したDICに対し遺伝子組換え型トロンボモジュリンが著効した一例Others
- AMERICAN ASSOCIATION FOR THE STUDY OF LIVER DISEASES(The Living Meeting 2018), Nov. 2013, English, AMERICAN ASSOCIATION FOR THE STUDY OF LIVER DISEASES, Washington, USA, International conferenceBack flow thrombectomy and PIHP for the treatment of multiple bilobular HCC with Vp4 PVTTPoster presentation
- AMERICAN ASSOCIATION FOR THE STUDY OF LIVER DISEASES(The Living Meeting 2016), Nov. 2013, English, AMERICAN ASSOCIATION FOR THE STUDY OF LIVER DISEASES, Washington, USA, International conferenceAssessment of ISGLS definition of posthepatectomy liver failure with hepatocellular carcinoma patientsPoster presentation
- JDDW2013(Japan Digestive Disease Week 2013)第21回日本消化器関連学会週間(消化器外科学会), Oct. 2013, Japanese, 日本消化器関連学会, 東京, Domestic conference膵臓ー集中学的治療2(司会進行)Others
- JDDW2013(Japan Digestive Disease Week 2013)第21回日本消化器関連学会週間(消化器外科学会), Oct. 2013, Japanese, 日本消化器関連学会, 東京, Domestic conference膵癌切除例における術後補助化学療法非完遂例の検討-術後血清アルブミン値の重要性-Poster presentation
- 第51回日本癌治療学会学術集会, Oct. 2013, Japanese, 日本癌治療学会, 京都, Domestic conference膵癌切除後早期再発の危険要因Oral presentation
- 第51回日本癌治療学会学術集会, Oct. 2013, Japanese, 日本癌治療学会, 京都, Domestic conference膵癌術後補助化学療法における血清アルブミン値の重要性Others
- JDDW2013(Japan Digestive Disease Week 2013)第21回日本消化器関連学会週間(消化器外科学会), Oct. 2013, Japanese, 日本消化器関連学会, 東京, Domestic conference膵癌との鑑別を要した自己免疫性膵炎症例の検討Poster presentation
- JDDW2013(Japan Digestive Disease Week 2013)第21回日本消化器関連学会週間(消化器外科学会), Oct. 2013, Japanese, 日本消化器関連学会, 東京, Domestic conference膵・胆管合流異常症に合併した胆道癌症例の検討Poster presentation
- JDDW2013(Japan Digestive Disease Week 2013)第21回日本消化器関連学会週間(消化器外科学会), Oct. 2013, Japanese, 日本消化器関連学会, 東京, Domestic conference腹部固形癌に対する粒子線とスペーサー外科手術を用いた治療限界の克服Poster presentation
- JDDW2013(Japan Digestive Disease Week 2013)第21回日本消化器関連学会週間(消化器外科学会), Oct. 2013, Japanese, 日本消化器関連学会, 東京, Domestic conference腹腔鏡下尾側膵切除術における手術手技の注意点 -切離部位に着目して-Poster presentation
- 第51回日本癌治療学会学術集会, Oct. 2013, Japanese, 日本癌治療学会, 京都, Domestic conference非切除進行・再発胆道癌に対する2次治療としてのS−1投与の役割Oral presentation
- JDDW2013(Japan Digestive Disease Week 2013)第21回日本消化器関連学会週間(消化器外科学会), Oct. 2013, Japanese, 日本消化器関連学会, 東京, Domestic conference背景肝も線維化を反映した肝切除術式:術前肝生検の問題点Others
- JDDW2013(Japan Digestive Disease Week 2013)第21回日本消化器関連学会週間(消化器外科学会), Oct. 2013, Japanese, 日本消化器関連学会, 東京, Domestic conference代謝酵素発現による胆道癌GEM術後補助投与の効果予測の検討Poster presentation
- JDDW2013(Japan Digestive Disease Week 2013)第21回日本消化器関連学会週間(消化器外科学会), Oct. 2013, Japanese, 日本消化器関連学会, 東京, Domestic conference臓器移植法改正後の劇症肝炎に対する肝移植Poster presentation
- 第51回日本癌治療学会学術集会, Oct. 2013, Japanese, 日本癌治療学会, 京都, Domestic conference進行肝細胞癌に対する新しい治療戦略Oral presentation
- JDDW2013(Japan Digestive Disease Week 2013)第21回日本消化器関連学会週間(消化器外科学会), Oct. 2013, Japanese, 日本消化器関連学会, 東京, Domestic conference浸潤性IPMNの術前診断による縮小手術の適応検討Poster presentation
- JDDW2013(Japan Digestive Disease Week 2013)第21回日本消化器関連学会週間(消化器外科学会), Oct. 2013, Japanese, 日本消化器関連学会, 東京, Domestic conference術中胆道造影において描出される膵管逆流現象の臨床的意義Poster presentation
- JDDW2013(Japan Digestive Disease Week 2013)第21回日本消化器関連学会週間(消化器外科学会), Oct. 2013, Japanese, 日本消化器関連学会, 東京, Domestic conference術前肝機能評価におけるアシアロシンチの有用性の検討Public symposium
- JDDW2013(Japan Digestive Disease Week 2013)第21回日本消化器関連学会週間(消化器外科学会), Oct. 2013, Japanese, 日本消化器関連学会, 東京, Domestic conference集学的治療により長期生存が得られている膵神経内分泌腫瘍の2例Poster presentation
- JDDW2013(Japan Digestive Disease Week 2013)第21回日本消化器関連学会週間(消化器外科学会), Oct. 2013, Japanese, 日本消化器関連学会, 東京, Domestic conference主膵管型IPMNに対する至適術式の検討Poster presentation
- 第51回日本癌治療学会学術集会, Oct. 2013, Japanese, 日本癌治療学会, 京都, Domestic conference高濃度Cisplatinを用いた肝動注療法の実現に向けた動物モデルの構築と基礎検討Others
- JDDW2013(Japan Digestive Disease Week 2013)第21回日本消化器関連学会週間(消化器外科学会), Oct. 2013, Japanese, 日本消化器関連学会, 東京, Domestic conference抗血栓薬服用例における胆嚢摘出術の検討Poster presentation
- JDDW2013(Japan Digestive Disease Week 2013)第21回日本消化器関連学会週間(消化器外科学会), Oct. 2013, Japanese, 日本消化器関連学会, 東京, Domestic conference局所進行肝癌に対するPIHPを基軸とした外科的治療戦略;どこまで治療可能か?Public symposium
- JDDW2013(Japan Digestive Disease Week 2013)第21回日本消化器関連学会週間(消化器外科学会), Oct. 2013, Japanese, 日本消化器関連学会, 東京, Domestic conference巨大肝癌に対する安全な肝切除の確立Public symposium
- JDDW2013(Japan Digestive Disease Week 2013)第21回日本消化器関連学会週間(消化器外科学会), Oct. 2013, Japanese, 日本消化器関連学会, 東京, Domestic conference肝門部胆管癌における胆管切離線決定のための術前画像診断法の比較Poster presentation
- 第51回日本癌治療学会学術集会, Oct. 2013, Japanese, 日本癌治療学会, 京都, Domestic conferenceスペーサー手術と粒子線照射による腹部・骨盤部悪性腫瘍の治療Oral presentation
- JDDW2013(Japan Digestive Disease Week 2013)第21回日本消化器関連学会週間(消化器外科学会), Oct. 2013, Japanese, 日本消化器関連学会, 東京, Domestic conference3cm, 3個以下の肝細胞癌に対する肝切除,生体肝移植の治療成績Poster presentation
- 第1回日本神経内分泌腫瘍研究会学術集会, Sep. 2013, Japanese, 日本神経内分泌腫瘍研究会, 京都, Domestic conference長期生存が得られている膵神経内分泌腫瘍術後再発の2例Poster presentation
- 第49回日本胆道学会学術集会, Sep. 2013, Japanese, 日本胆道学会, 千葉, Domestic conference胆道癌非切除例に対する集学的治療(抗癌剤、粒子線治療)の成績Oral presentation
- 第49回日本胆道学会学術集会, Sep. 2013, Japanese, 日本胆道学会, 千葉, Domestic conference胆管内乳頭状腫瘍(IPNB)自験例6例の検討Poster presentation
- 第49回日本移植学会, Sep. 2013, Japanese, 日本移植学会, 京都, Domestic conference肝移植後長期合併症の管理Others
- IAP&KPBA2013, Sep. 2013, English, International Association of Pancreatology, Seoul, Korea, International conferenceUsefulness of WHO 2010 classification as a predictor of postoperative recurrence in patients with pancreatic neuroendocrine tumors.Poster presentation
- The 12th Awaji International Forum on Infection and Immunity, Sep. 2013, English, 東京大学医科学研究所, 淡路島, International conferenceQuantification of pregenomic RNA and covelently closed circular DNA in hepatitis B virus related hepatocellular carcinomaPoster presentation
- IAP&KPBA2013, Sep. 2013, English, International Association of Pancreatology, Seoul, Korea, International conferencePostoperative serum albumin level is an independent risk factor for discontinuation of adjuvant chemotherapy for pancreatic cancerPoster presentation
- IAP&KPBA2013, Sep. 2013, English, International Association of Pancreatology, Seoul, Korea, International conferenceMetachronous remnant pancreatic suctal adenocarcinoma after pancreatectomyPoster presentation
- The 13th Congress of the Asian Society of Transplantation, Sep. 2013, English, Congress of the Asian Society of Transplantation, Kyoto, Japan, International conferenceLOW-DOSE ANTIVIRAL TREATMENT FOR HEPATITIS C VIRUS FOLLOWING LIVING DONOR LIVER TRANSPLANTATION WITHOUT SPLENECTOMYOthers
- The 13th Congress of the Asian Society of Transplantation, Sep. 2013, English, Congress of the Asian Society of Transplantation, Kyoto, Japan, International conferenceLong-term complications after liver transplantationPoster presentation
- IAP&KPBA2013, Sep. 2013, English, International Association of Pancreatology, Seoul, Korea, International conferenceIndication of pancreatoduodenectomy following severe acute pancreatitis in patients with distal bile duct or pancreas head cancer.Poster presentation
- The 13th Congress of the Asian Society of Transplantation, Sep. 2013, English, Congress of the Asian Society of Transplantation, Kyoto, Japan, International conferenceFunctioning graftpancreas with thromboses of splenic and superior mesenteric arter simultaneous pancreas-kidney transplantation : A case reportPoster presentation
- The 13th Congress of the Asian Society of Transplantation, Sep. 2013, English, Congress of the Asian Society of Transplantation, Kyoto, Japan, International conferenceEvaluation of the glucose metabolism after distal pancreas transplantation guideline proposed by Japanese Pancreas and Islet Transplantation Association.Poster presentation
- 第49回日本胆道学会学術集会, Sep. 2013, Japanese, 日本胆道学会, 千葉, Domestic conferenceDifficult Stone に対する外科的治療戦略Poster presentation
- IAP&KPBA2013, Sep. 2013, English, International Association of Pancreatology, Seoul, Korea, International conferenceA prospective randomized comparison between pylorus -preserving and subtotal stomach-preserving pancreatoduodenectomy on postoperative delayed gastric emptying occurrence and long-term nutritional status in patients with periampullary lesionsPoster presentation
- 第40回日本膵切研究会, Aug. 2013, Japanese, 日本膵切研究会, 高松, Domestic conference膵頭十二指腸切除を施行したPortal annular pancreasの3例Poster presentation
- International Surgical Week 2013, Aug. 2013, English, INTERNATIONAL SOCIETY OF SURGERY, Helsinki, Finland, International conferenceLaparoscopic cholecystectomy in patients with liver cirrhosisPoster presentation
- 第40回日本膵切研究会, Aug. 2013, Japanese, 日本膵切研究会, 高松, Domestic conferenceIPMNに対する縮小手術としての腹腔鏡下尾側膵切除術の適応Others
- International Surgical Week 2013, Aug. 2013, English, INTERNATIONAL SOCIETY OF SURGERY, Helsinki, Finland, International conferenceFactors affecting survival after resection in patients with intrahepatic cholangiocarcinomaPoster presentation
- International Surgical Week 2013, Aug. 2013, English, INTERNATIONAL SOCIETY OF SURGERY, Helsinki, Finland, International conferenceClinical use of double-balloon endoscopy after roux-y biliary reconstructionPoster presentation
- International Surgical Week 2013, Aug. 2013, English, INTERNATIONAL SOCIETY OF SURGERY, Helsinki, Finland, International conferenceBiliary re-reconstruction in patients with biliary diseasePoster presentation
- International Surgical Week 2013, Aug. 2013, English, INTERNATIONAL SOCIETY OF SURGERY, Helsinki, Finland, International conferenceBile duct resection in upper and middle bile duct cancerPoster presentation
- 第68回日本消化器外科学会総会, Jul. 2013, Japanese, 日本消化器外科学会, 宮崎, Domestic conference膵切除後腹腔内出血に対する治療戦略Others
- 第68回日本消化器外科学会総会, Jul. 2013, Japanese, 日本消化器外科学会, 宮崎, Domestic conference膵癌長期生存例の検討」Others
- 第49回日本肝癌研究会, Jul. 2013, Japanese, 日本肝癌研究会, 東京, Domestic conference門脈腫瘍栓を伴う巨大肝癌に対する肝切除術Others
- 第68回日本消化器外科学会総会, Jul. 2013, Japanese, 日本消化器外科学会, 宮崎, Domestic conference腹腔動脈幹合併膵体尾部切除術後の仮性動脈瘤出血に対し、TATと開腹ドレナージにより救命した一例Others
- 第68回日本消化器外科学会総会, Jul. 2013, Japanese, 日本消化器外科学会, 宮崎, Domestic conference当科における肝切除の工夫-腹腔鏡下肝切除から巨大肝癌切除まで-Others
- 第68回日本消化器外科学会総会, Jul. 2013, Japanese, 日本消化器外科学会, 宮崎, Domestic conference超進行肝癌に対するPIHPを基軸とした治療戦略:Back Flow Perfusion法と3段階治療の役割[Invited]Nominated symposium
- 第68回日本消化器外科学会総会, Jul. 2013, Japanese, 日本消化器外科学会, 宮崎, Domestic conference胆道再建術後の胆道再々建術施行例の検討Others
- 第68回日本消化器外科学会総会, Jul. 2013, Japanese, 日本消化器外科学会, 宮崎, Domestic conference胆道癌におけるERCP下細胞診および生検の有用性Others
- 第68回日本消化器外科学会総会, Jul. 2013, Japanese, 日本消化器外科学会, 宮崎, Domestic conference大動脈周囲リンパ節陽性胆道癌の切除成績Others
- 第68回日本消化器外科学会総会, Jul. 2013, Japanese, 日本消化器外科学会, 宮崎, Domestic conference腎癌膵転移に対して二度の膵切除を行なった一例〜当科における腎癌膵転移症例の検討Others
- 第68回日本消化器外科学会総会, Jul. 2013, Japanese, 日本消化器外科学会, 宮崎, Domestic conference心血管疾患に対する抗凝固療法加療例における胆嚢摘出術の検討Others
- 第68回日本消化器外科学会総会, Jul. 2013, Japanese, 日本消化器外科学会, 宮崎, Domestic conference上中部胆管癌に対する胆管切除術の成績Others
- 第68回日本消化器外科学会総会, Jul. 2013, Japanese, 日本消化器外科学会, 宮崎, Domestic conference高齢者膵癌に対する治療選択と成績Others
- 第68回日本消化器外科学会総会, Jul. 2013, Japanese, 日本消化器外科学会, 宮崎, Domestic conference巨大肝細胞癌に対する右肝切除術Others
- 第68回日本消化器外科学会総会, Jul. 2013, Japanese, 日本消化器外科学会, 宮崎, Domestic conference肝門部胆管癌の肝側胆管切離線決定における3D-CT胆管像の有用性Others
- 第68回日本消化器外科学会総会, Jul. 2013, Japanese, 日本消化器外科学会, 宮崎, Domestic conference肝切除における合併症予防策Others
- 第68回日本消化器外科学会総会, Jul. 2013, Japanese, 日本消化器外科学会, 宮崎, Domestic conference肝右葉切除の術前評価における99mTc-GASシンチグラフィーの有用性Public symposium
- 第31回日本肝移植研究会, Jul. 2013, Japanese, 日本肝移植研究会, 熊本, Domestic conference「生体肝移植後直腸癌とグラフト肝への転移を併発した1例」Oral presentation
- 第31回日本肝移植研究会, Jul. 2013, Japanese, 日本肝移植研究会, 熊本, Domestic conference「生体肝移植ドナー手術におけるソナゾイドを用いた術中超音波下胆道造影法」Others
- 第31回日本肝移植研究会, Jul. 2013, Japanese, 日本肝移植研究会, 熊本, Domestic conference「肝移植後長期生着を目指して」Oral presentation
- 第68回日本消化器外科学会総会, Jul. 2013, Japanese, 日本消化器外科学会, 宮崎, Domestic conferenceソナゾイド術中超音波下胆道造影を用いた肝胆道ナビゲーション手術Public symposium
- 第68回日本消化器外科学会総会, Jul. 2013, Japanese, 日本消化器外科学会, 宮崎, Domestic conferenceIPMNに対する縮小手術の適応Others
- 第68回日本消化器外科学会総会, Jul. 2013, Japanese, 日本消化器外科学会, 宮崎, Domestic conference3cm, 3個以下の肝細胞癌に対する肝切除,生体肝移植の治療成績Others
- 第25回日本肝胆膵外科学会・学術集会, Jun. 2013, Japanese, 日本肝胆膵外科学会, 栃木, Domestic conference膵頭十二指腸切除術における安全、確実な膵空腸吻合手術手技Others
- 第25回日本肝胆膵外科学会・学術集会, Jun. 2013, Japanese, 日本肝胆膵外科学会, 栃木, Domestic conference膵移植血行再建術の手術手技Others
- 第25回日本肝胆膵外科学会・学術集会, Jun. 2013, Japanese, 日本肝胆膵外科学会, 栃木, Domestic conference膵移植の工夫Others
- 第25回日本肝胆膵外科学会・学術集会, Jun. 2013, Japanese, 日本肝胆膵外科学会, 栃木, Domestic conference腹腔動脈幹合併膵体尾部切除術後の膵瘻による仮性動脈瘤出血に対し、TATと開腹ドレナージにて救命した一例Poster presentation
- 第25回日本肝胆膵外科学会・学術集会, Jun. 2013, Japanese, 日本肝胆膵外科学会, 栃木, Domestic conference腹腔鏡下脾臓・脾動静脈温存膵体尾部切除術の問題点Others
- 第25回日本肝胆膵外科学会・学術集会, Jun. 2013, Japanese, 日本肝胆膵外科学会, 栃木, Domestic conference当科での肝癌に対する肝切除術の工夫Public symposium
- 第25回日本肝胆膵外科学会・学術集会, Jun. 2013, Japanese, 日本肝胆膵外科学会, 栃木, Domestic conference中部胆管癌に対する胆管切除術後6ヶ月で発症した下部胆管癌の1切除例Poster presentation
- 第25回日本肝胆膵外科学会・学術集会, Jun. 2013, Japanese, 日本肝胆膵外科学会, 栃木, Domestic conference大動脈周囲リンパ節陽性胆道癌の切除成績Public symposium
- 第25回日本肝胆膵外科学会・学術集会, Jun. 2013, Japanese, 日本肝胆膵外科学会, 栃木, Domestic conference神戸大学における非B非C肝癌の外科的治療成績Public symposium
- 第25回日本肝胆膵外科学会・学術集会, Jun. 2013, Japanese, 日本肝胆膵外科学会, 栃木, Domestic conference術前胆道ドレナージ症例における術後胆管炎の検討Poster presentation
- 第25回日本肝胆膵外科学会・学術集会, Jun. 2013, Japanese, 日本肝胆膵外科学会, 栃木, Domestic conference重症急性膵炎併発例に対する膵頭十二指腸切除術の手術手技Public symposium
- 第49回日本肝臓学会総会, Jun. 2013, Japanese, 日本肝臓学会, 東京, Domestic conference手術[Invited]Invited oral presentation
- 第25回日本肝胆膵外科学会・学術集会, Jun. 2013, Japanese, 日本肝胆膵外科学会, 栃木, Domestic conference自験例からみた主膵管型IPMNに対する至適術式の検討Poster presentation
- 第25回日本肝胆膵外科学会・学術集会, Jun. 2013, Japanese, 日本肝胆膵外科学会, 栃木, Domestic conference高度門脈血栓合併症例に対する門脈再建術の工夫Public symposium
- 第25回日本肝胆膵外科学会・学術集会, Jun. 2013, Japanese, 日本肝胆膵外科学会, 栃木, Domestic conference高度脈管侵襲合併肝細胞癌に対する肝切除Public symposium
- 第25回日本肝胆膵外科学会・学術集会, Jun. 2013, Japanese, 日本肝胆膵外科学会, 栃木, Domestic conference癌幹細胞マーカーCD133の発現からみたIPNBと膵IPMNの類似性Poster presentation
- 第25回日本肝胆膵外科学会・学術集会, Jun. 2013, Japanese, 日本肝胆膵外科学会, 栃木, Domestic conference肝胆道外科領域における当科の術前シミュレーションの取り組みPublic symposium
- 第25回日本肝胆膵外科学会・学術集会, Jun. 2013, Japanese, 日本肝胆膵外科学会, 栃木, Domestic conference肝臓:胆管』細胞癌(座長)Others
- 第25回日本肝胆膵外科学会・学術集会, Jun. 2013, Japanese, 日本肝胆膵外科学会, 栃木, Domestic conference肝細胞癌多発肺転移、リンパ節転移に対し集学的治療を行い、長期生存を得た1例Others
- 第25回日本肝胆膵外科学会・学術集会, Jun. 2013, Japanese, 日本肝胆膵外科学会, 栃木, Domestic conference肝癌診療ガイドラインを越えた肝細胞癌治療の現況Public symposium
- 21st International Congress of the European Association for Endoscopic Surgery (EAES), Jun. 2013, English, European Association for Endoscopic Surgery, Vienna, Austria, International conferenceLAPAROSCOPIC DISTAL PANCREATECTOMY : A SINGLE CENTER EXPERIENCE FOR STANDARDIZED PROCEDUREPoster presentation
- 第35回日本癌局所療法研究会, May 2013, Japanese, 日本癌局所療法研究会, 神戸, Domestic conference切除不能胆嚢癌に対し化学療法施行後に切除を施行した1例Oral presentation
- 第35回日本癌局所療法研究会, May 2013, Japanese, 日本癌局所療法研究会, 神戸, Domestic conference進行肝細胞癌に対する粒子線治療後にPIHPを施行した症例の検討Oral presentation
- 第35回日本癌局所療法研究会, May 2013, Japanese, 日本癌局所療法研究会, 神戸, Domestic conference初回切除後4年で発症した異時性膵癌の1例Oral presentation
- 第67回手術手技研究会, May 2013, Japanese, 手術手技研究会, 札幌, Domestic conference重症急性膵炎後の膵頭十二指腸切除術-剥離・切離操作における当科の工夫-Others
- 第35回日本癌局所療法研究会, May 2013, Japanese, 日本癌局所療法研究会, 神戸, Domestic conference集学的治療における術前経皮的肝灌流化学療法と肝切除の位置づけOral presentation
- 第35回日本癌局所療法研究会, May 2013, Japanese, 日本癌局所療法研究会, 神戸, Domestic conference集学的治療で長期生存中の大動脈周囲リンパ節陽性胆管癌の1例Oral presentation
- AMERICAN TRANSPLANT CONGRESS2013, May 2013, English, AMERICAN TRANSPLANT CONGRESS, Seatle, America, International conferenceAnalysis of Portal Vein Reconstruction for LDLT Recipients with Portal Vein Thrombus.Poster presentation
- 第113回日本外科学会定期学術集会, Apr. 2013, Japanese, 日本外科学会, 福岡, Domestic conference膵頭十二指腸切除術後出血例に対する治療選択と成績Poster presentation
- 第113回日本外科学会定期学術集会, Apr. 2013, Japanese, 日本外科学会, 福岡, Domestic conference腹腔鏡下脾臓・脾動静脈温存膵体尾部切除術の適応と問題点Others
- 第113回日本外科学会定期学術集会, Apr. 2013, Japanese, 日本外科学会, 福岡, Domestic conference費用対効果からみた肝門部胆管癌切除例,非切除例の医療費の検討Poster presentation
- 第113回日本外科学会定期学術集会, Apr. 2013, Japanese, 日本外科学会, 福岡, Domestic conference粘液産生胆管腫瘍(IPNB)からの細胞株樹立Others
- 第113回日本外科学会定期学術集会, Apr. 2013, Japanese, 日本外科学会, 福岡, Domestic conference当科における成人生体肝移植後胆道合併症の現状Poster presentation
- 第113回日本外科学会定期学術集会, Apr. 2013, Japanese, 日本外科学会, 福岡, Domestic conference超高齢者膵癌に対する治療成績Poster presentation
- 第113回日本外科学会定期学術集会, Apr. 2013, Japanese, 日本外科学会, 福岡, Domestic conference切除可能膵癌に対する術後補助化学療法の検討Poster presentation
- 第113回日本外科学会定期学術集会, Apr. 2013, Japanese, 日本外科学会, 福岡, Domestic conference高度門脈血栓合併症例に対する門脈再建術Others
- 第113回日本外科学会定期学術集会, Apr. 2013, Japanese, 日本外科学会, 福岡, Domestic conference肝胆道疾患におけるソナゾイドを用いた超音波下胆道造影による術中胆道ナビゲーションの有用性Others
- 第114回日本外科学会定期学術集会, Apr. 2013, Japanese, 日本外科学会, 福岡, Domestic conference肝 進行癌(司会進行)Others
- 第113回日本外科学会定期学術集会, Apr. 2013, Japanese, 日本外科学会, 福岡, Domestic conference肝細胞癌患者におけるPHLFの検討;新たな肝予備能評価方法の立案にむけてPoster presentation
- 第113回日本外科学会定期学術集会, Apr. 2013, Japanese, 日本外科学会, 福岡, Domestic conference肝外胆管癌に対する肝外胆管切除術の治療成績Poster presentation
- 第113回日本外科学会定期学術集会, Apr. 2013, Japanese, 日本外科学会, 福岡, Domestic conference肝移植医療のさらなる普及と脳死移植発展のために今必要とされること-市中病院および移植施設における移植外科医の役割-Poster presentation
- 第113回日本外科学会定期学術集会, Apr. 2013, Japanese, 日本外科学会, 福岡, Domestic conference外科的治療限界の克服:スペーサー手術と粒子線治療の融合Others
- 第113回日本外科学会定期学術集会, Apr. 2013, Japanese, 日本外科学会, 福岡, Domestic conference80歳以上の高齢者における肝細胞癌切除例Poster presentation
- 第113回日本外科学会定期学術集会, Apr. 2013, Japanese, 日本外科学会, 福岡, Domestic conference2010年WHO分類に基づく膵神経内分泌腫瘍(qNET)の術後再発予測に関する検討Poster presentation
- 第40回日本膵・膵島移植研究会, Mar. 2013, Japanese, 日本膵・膵島移植研究会, 香川, Domestic conference膵グラフト血栓3例の検討Oral presentation
- 第99回日本消化器病学会総会, Mar. 2013, Japanese, 日本消化器病学会, 鹿児島, Domestic conference陽子線治療を行なった局所進行切除不能膵癌の2剖検例Poster presentation
- 第99回日本消化器病学会総会, Mar. 2013, Japanese, 日本消化器病学会, 鹿児島, Domestic conference走査型蛍光X線顕微鏡を用いた肝組織内鉄分布の解析Public symposium
- 第99回日本消化器病学会総会, Mar. 2013, Japanese, 日本消化器病学会, 鹿児島, Domestic conference進行肝細胞癌における経皮的肝灌流化学療法の位置づけPublic symposium
- 第99回日本消化器病学会総会, Mar. 2013, Japanese, 日本消化器病学会, 鹿児島, Domestic conference神戸大学における臓器移植法改正後の肝移植の現状Public symposium
- 第17回兵庫粒子線治療研究会のご案内, Mar. 2013, Japanese, 兵庫粒子線治療研究会, 兵庫(生田神社会館), 【目的】重要臓器と近接しているために粒子線・放射線治療が難しい疾患に対する新たな治療法の開発のため、スペーサーをマウス腹部に留置し、毒性を含む生物学的反応とスペーサーの有用性を検討する。【方法】スペーサーをマウス腹部に留置し、一定の観察期間後、スペーサーが生体に及ぼす毒性に関して全血を採取し生化学検査により評価した。また、スペーサーを留置したマウスに対して炭素線を用いた照射実験を行い、スペーサーの有用性を検討した。【結果】採血によるスペーサーの毒性評価では、肝臓、腎臓、膵臓など主要臓器機能に明らかな異常値は認められなかったが、採取可能な血液が少ないことから、無毒性という確定できなかった。照射後の体重の変化を検討したが、スペーサーによる腸管への線量低減効果が示唆された。組織学的検討ではスペーサー周囲に炎症細胞浸潤が認められた。, Domestic conference新規体内吸収性PGA spacerの基礎研究開発Oral presentation
- 第49回日本腹部救急医学会総会, Mar. 2013, Japanese, 日本腹部救急医学会, 福岡, Domestic conference術前胆管炎コントロールに難渋した肝門部胆管癌の一切除例Oral presentation
- 第49回日本腹部救急医学会総会, Mar. 2013, Japanese, 日本腹部救急医学会, 福岡, Domestic conferenceRoux-Y 胆道再建術後症例に対するダブルバルーン内視鏡の有用性Public symposium
- 第99回日本消化器病学会総会, Mar. 2013, Japanese, 日本消化器病学会, 鹿児島, Domestic conferenceIPMN切除例における浸潤・リンパ節転移予測因子の検討Oral presentation
- 第49回日本腹部救急医学会総会, Mar. 2013, Japanese, 日本腹部救急医学会, 福岡, Domestic conferenceERCPによる重症急性膵炎発症後の膵頭部悪性腫瘍手術症例の検討Oral presentation
- 第40回日本膵・膵島移植研究会, Mar. 2013, Japanese, 日本膵・膵島移植研究会, 香川, Domestic conference31P-NMRと二層法負荷試験を併用した移植前膵島機能評価法Others
- 日本消化器病学会近畿支部第98回例会, Feb. 2013, Japanese, 日本消化器病学会, 神戸, Domestic conference肝細胞癌に対する治療戦略Others
- The 8th International Meeting of Hepatocellular Carcinoma:Eastern and Western Experiences, Feb. 2013, Japanese, 東京大学肝胆膵外科, Tokyo, International conferenceRt.hemihepatectomy for huge hepatocellular carcinomaPoster presentation
- The 8th International Meeting of Hepatocellular Carcinoma:Eastern and Western Experiences, Feb. 2013, Japanese, 東京大学肝胆膵外科, Tokyo, International conferenceBack flow thrombectomy and PIHP for treatment of Vp4multiple bilobar HCCOral presentation
- 2013 Gastrointestinal Cancers Symposium, Jan. 2013, Japanese, ASC, San Francisco, USA, International conferenceUsefulness of FDG-PET in the evaluation of tumor response to proton beam therapy for locally advanced pancreatic ductal adenocarcinoma.Poster presentation
- 第25回日本内視鏡外科学会総会, Dec. 2012, Japanese, 日本内視鏡外科学会, 横浜, Domestic conference腹腔鏡下尾側膵切除術ー導入と術式の定型化へ向けてーOral presentation
- 第25回日本内視鏡外科学会総会, Dec. 2012, Japanese, 日本内視鏡外科学会, 横浜, Domestic conference腹腔鏡下尾側膵切除術における術中出血への対策Oral presentation
- 第25回日本内視鏡外科学会総会, Dec. 2012, Japanese, 日本内視鏡外科学会, 横浜, Domestic conference肝臓外科領域における当科の術前シミュレーション・術中ナビゲーションの取り組みPublic symposium
- 第25回日本内視鏡外科学会総会, Dec. 2012, Japanese, 日本内視鏡外科学会, 横浜, Domestic conference肝硬変症例に対する腹腔鏡下胆嚢摘出術の成績Oral presentation
- 第4回膵臓内視鏡外科研究会, Nov. 2012, Japanese, 膵臓内視鏡外科研究会, 東京, Domestic conference膵切離部位に着目した腹腔鏡下膵体尾部切除術における手技のポイントPublic symposium
- 第74回日本臨床外科学会総会, Nov. 2012, Japanese, 日本臨床外科学会, 東京, Domestic conference膵切除における手術手技の工夫(生食滴下式バイポーラを用いた手術手技)Oral presentation
- 第74回日本臨床外科学会総会, Nov. 2012, Japanese, 日本臨床外科学会, 東京, Domestic conference膵癌鑑別診断および術前診断におけるFDG-PETの位置づけOral presentation
- 第74回日本臨床外科学会総会, Nov. 2012, Japanese, 日本臨床外科学会, 東京, Domestic conference門脈腫瘍栓(Vp4)合併肝細胞癌に対する肝切除の工夫と集学的治療としてのPIHPの有効性Oral presentation
- 第74回日本臨床外科学会総会, Nov. 2012, Japanese, 日本臨床外科学会, 東京, Domestic conference腹腔鏡下尾側膵切除術ー安全な術式の定型化ーPublic symposium
- 第6回肝臓内視鏡外科研究会, Nov. 2012, Japanese, 肝臓内視鏡外科研究会, 東京, Domestic conference当科における腹腔鏡下肝切除の導入と適応拡大Oral presentation
- 第74回日本臨床外科学会総会, Nov. 2012, Japanese, 日本臨床外科学会, 東京, Domestic conference当院における単孔式腹腔鏡下胆嚢摘出術の成績Oral presentation
- 第74回日本臨床外科学会総会, Nov. 2012, Japanese, 日本臨床外科学会, 東京, Domestic conference胆嚢癌との鑑別診断が困難であった黄色肉芽腫性胆嚢炎の1例Oral presentation
- 日本放射線腫瘍学会第25回学術大会, Nov. 2012, Japanese, 日本放射線腫瘍学会, 東京(東京国際フォーラム), Physicaly and biological experimental outcomes of originally established absorbant spacer was explained, Domestic conference大型動物を用いた体内吸収性スペーサーの長期安全性の検討Oral presentation
- 第192回近畿外科学会, Nov. 2012, Japanese, 近畿外科学会, 大阪, Domestic conference切除範囲決定に経口胆道鏡(POCS)を使用した広範囲胆管癌の1例Oral presentation
- 第74回日本臨床外科学会総会, Nov. 2012, Japanese, 日本臨床外科学会, 東京, Domestic conference切除断端、断端距離から見た肝内胆管癌の手術戦略Oral presentation
- 第192回近畿外科学会, Nov. 2012, Japanese, 近畿外科学会, 大阪, Domestic conference腎癌術後膵転移に対し2度の膵切除を行なった1例Oral presentation
- 第74回日本臨床外科学会総会, Nov. 2012, Japanese, 日本臨床外科学会, 東京, Domestic conference女性外科医としてOral presentation
- 第74回日本臨床外科学会総会, Nov. 2012, Japanese, 日本臨床外科学会, 東京, Domestic conference主膵管型IPMNに対する術前診断と術式選択Oral presentation
- 第74回日本臨床外科学会総会, Nov. 2012, Japanese, 日本臨床外科学会, 東京, Domestic conference細径膵管例における確実な膵空腸吻合手術手技Oral presentation
- 第74回日本臨床外科学会総会, Nov. 2012, Japanese, 日本臨床外科学会, 東京, Domestic conference肝門部胆管癌の術前診断で切除したIgG4関連硬化性胆管炎の1例Oral presentation
- 第74回日本臨床外科学会総会, Nov. 2012, Japanese, 日本臨床外科学会, 東京, Domestic conference肝臓(良性)2Others
- 第74回日本臨床外科学会総会, Nov. 2012, Japanese, 日本臨床外科学会, 東京, Domestic conferenceソナゾイドによる術中超音波胆道造影を用いた肝切除術Oral presentation
- The 63rd Annual Meeting of the American Association for the Study of Liver Diseases, Nov. 2012, Japanese, AASLD, Boston, USA, International conferenceLong-Term Outcomes and Prognostic Factors with Reductive Hepatectomy and Sequential Percutaneous Isolated Hepatic Perfusion for Multiple Bilobar-Hepatocellular CarcinomaPoster presentation
- 第74回日本臨床外科学会総会, Nov. 2012, Japanese, 日本臨床外科学会, 東京, Domestic conferenceHepatomesenteric type の肝動脈走行変異を伴う十二指腸乳頭部癌に対してSSPPDを施行した1例Oral presentation
- 第74回日本臨床外科学会総会, Nov. 2012, Japanese, 日本臨床外科学会, 東京, Domestic conferenceHanging maneuver を用いた巨大肝細胞癌に対する安全な肝右肝切除術Oral presentation
- The 63rd Annual Meeting of the American Association for the Study of Liver Diseases, Nov. 2012, Japanese, AASLD, Boston, USA, International conferenceFragility Index,a Novel Predictor to Assess Deterioration Speed of Renal Function after Living Donor Liver TransplantationPoster presentation
- JDDW 2012 (Japan Digestive Disease Week 2012) 第20 回日本消化器関連学会週間(消化器外科学会), Oct. 2012, Japanese, 日本消化器関連学会, 神戸, Domestic conference膵切除術における胃切除術既往の影響Poster presentation
- 第50回日本癌治療学会学術集会, Oct. 2012, Japanese, 日本癌治療学会, 横浜, Domestic conference膵癌の診断・治療方針決定におけるFDG-PETの有用性の検討Oral presentation
- JDDW 2012 (Japan Digestive Disease Week 2012) 第20 回日本消化器関連学会週間(消化器外科学会), Oct. 2012, Japanese, 日本消化器関連学会, 神戸, Domestic conference膵癌に対する陽子線治療効果判定におけるFDG-PETの有用性Poster presentation
- JDDW 2012 (Japan Digestive Disease Week 2012) 第20 回日本消化器関連学会週間(消化器外科学会), Oct. 2012, Japanese, 日本消化器関連学会, 神戸, Domestic conference胆道癌におけるERC下細胞診および生検の術前診断における役割Poster presentation
- JDDW 2012 (Japan Digestive Disease Week 2012) 第20 回日本消化器関連学会週間(消化器外科学会), Oct. 2012, Japanese, 日本消化器関連学会, 神戸, Domestic conference術式の工夫と内視鏡的処置で治療し得た肝内結石症の1例Poster presentation
- 第50回日本癌治療学会学術集会, Oct. 2012, Japanese, 日本癌治療学会, 横浜, Domestic conference集学的治療により長期生存を得ている大動脈周囲リンパ節転移陽性胆管癌の1例Poster presentation
- JDDW 2012 (Japan Digestive Disease Week 2012) 第20 回日本消化器関連学会週間(消化器外科学会), Oct. 2012, Japanese, 日本消化器関連学会, 神戸, Domestic conference細胆管癌切除3例の検討Poster presentation
- JDDW 2012 (Japan Digestive Disease Week 2012) 第20 回日本消化器関連学会週間(消化器外科学会), Oct. 2012, Japanese, 日本消化器関連学会, 神戸, Domestic conference高度脈管侵襲を伴う進行肝細胞癌に対する集学的治療Poster presentation
- JDDW 2012 (Japan Digestive Disease Week 2012) 第20 回日本消化器関連学会週間(消化器外科学会), Oct. 2012, Japanese, 日本消化器関連学会, 神戸, Domestic conference肝門部周囲胆管癌に対する術前造影下3D—CT胆管像の有用性Public symposium
- The 9th Korea-Japan Transplantation Forum, Oct. 2012, Japanese, The Korean Society for Transplantation, Korea, International conferenceFragility Index,a Novel Predictor to Assess CKD after Living Donor Liver TransplantationPoster presentation
- International Symposium on Pancreas Cancer 2012, Oct. 2012, English, 京都大学, Kyoto, International conferenceEvaluation of adjuvant chemotherapy in patients with advanced pancreatic cancerPoster presentation
- 54th ASTRO Annual Meeting, Oct. 2012, English, ASTRO, U.S.A , Boston, Purpose/Objective(s): Particle beams, such as proton and carbon ion beams, have demonstrated an increase in energy deposition with a penetration depth up to a sharp maximum at the end of their range: the so-called Bragg peak phenomenon. With current metho, International conferenceEfficacy of Surgically Implanted Flexible Spacer in Particle Therapy: A novel strategy Making Temporal Space between Tumor and Adjacent OrgansPoster presentation
- The 9th Korea-Japan Transplantation Forum, Oct. 2012, Japanese, The Korean Society for Transplantation, Korea, International conferenceA Case of Strongly Suspected Acute GVHD Following Simultaneous Pancreas-kidney TransplantPoster presentation
- 第48回日本移植学会総会, Sep. 2012, Japanese, 日本移植学会, 愛知, Domestic conference門脈血栓症を合併した症例に対する門脈再建術の検討Oral presentation
- 第35回日本膵・胆管合流異常研究会, Sep. 2012, Japanese, 日本膵・胆管合流異常研究会, 東京, Domestic conference非拡張型膵・胆管合流異常に肝門部胆管癌、胆嚢癌の重複癌を合併した一例Oral presentation
- 第48回日本胆道学会学術集会, Sep. 2012, Japanese, 日本胆道学会, 東京, Domestic conference早期乳頭部癌の臨床的特徴と治療Oral presentation
- 第48回日本胆道学会学術集会, Sep. 2012, Japanese, 日本胆道学会, 東京, Domestic conference肝外胆管癌に対する肝外胆管切除術の成績Oral presentation
- 第48回日本移植学会総会, Sep. 2012, Japanese, 日本移植学会, 愛知, Domestic conferenceグラフト脾動脈・上腸間膜動脈血栓をきたした膵腎同時移植の1生着例Poster presentation
- 日本消化器病学会近畿支部 第97回例会, Sep. 2012, Japanese, 日本消化器病学会, 京都, Domestic conferenceVater 乳頭近傍原発巨大GISTの1切除例Oral presentation
- 第39回日本膵切研究会, Aug. 2012, Japanese, 日本膵切研究会, 東京, Domestic conference腹腔鏡下尾側膵切除術の定型化と今後の課題Oral presentation
- 第39回日本膵切研究会, Aug. 2012, Japanese, 日本膵切研究会, 東京, Domestic conference尾側膵切除における手術手技の工夫ー生食滴下式バイポーラを用いた手術手技ーPoster presentation
- 第57回日本消化器画像診断研究会, Aug. 2012, Japanese, 日本消化器画像診断研究会, 宮城, Domestic conference悪性リンパ腫経過中に発生した十二指腸浸潤をともなう oncocystic type IPMC と診断した1例Oral presentation
- 第67回日本消化器外科学会総会, Jul. 2012, Japanese, 日本消化器外科学会, 富山, Domestic conference膵頭十二指腸切除後出血〜救命のための対策〜Oral presentation
- 第67回日本消化器外科学会総会, Jul. 2012, Japanese, 日本消化器外科学会, 富山, Domestic conference膵胆管合流異常症に対する至適術式の検討Oral presentation
- 第10回日本臨床腫瘍学会学術集会, Jul. 2012, Japanese, 日本臨床腫瘍学会, 大阪, Domestic conference膵癌診療における神戸大学 Pancreatic Cancer Boardの役割The role of the Cancer Board in the treatment of pancreatic cancerPoster presentation
- 第67回日本消化器外科学会総会, Jul. 2012, Japanese, 日本消化器外科学会, 富山, Domestic conference良低悪性度膵疾患に対する腹腔鏡下膵切除術の術前診断と適応Oral presentation
- 第48回日本肝癌研究会, Jul. 2012, Japanese, 日本肝癌研究会, 石川, Domestic conference門脈腫瘍栓合併進行肝癌に対する肝切除:Back Flow Perfusion による腫瘍栓の摘出Oral presentation
- 第67回日本消化器外科学会総会, Jul. 2012, Japanese, 日本消化器外科学会, 富山, Domestic conference慢性肝疾患例における膵頭十二指腸切除後合併症の検討Oral presentation
- 第67回日本消化器外科学会総会, Jul. 2012, Japanese, 日本消化器外科学会, 富山, Domestic conference閉塞性黄疸を伴う胆道癌患者における術前減黄法の比較Public symposium
- 第67回日本消化器外科学会総会, Jul. 2012, Japanese, 日本消化器外科学会, 富山, Domestic conference乳頭部癌再発症例の検討Oral presentation
- 第67回日本消化器外科学会総会, Jul. 2012, Japanese, 日本消化器外科学会, 富山, Domestic conference当科におけるpT2胆嚢癌に対する術式の検討Oral presentation
- 第67回日本消化器外科学会総会, Jul. 2012, Japanese, 日本消化器外科学会, 富山, Domestic conference超高齢者膵癌に対する治療選択と切除成績Oral presentation
- 第67回日本消化器外科学会総会, Jul. 2012, Japanese, 日本消化器外科学会, 富山, Domestic conference胆嚢癌疑診例に対する胆嚢内胆汁細胞診の有用性Oral presentation
- 第67回日本消化器外科学会総会, Jul. 2012, Japanese, 日本消化器外科学会, 富山, Domestic conference進行膵癌に対する術後補助化学療法の成績と問題点Oral presentation
- 第67回日本消化器外科学会総会, Jul. 2012, Japanese, 日本消化器外科学会, 富山, Domestic conference進行再発肝癌に対する治療戦略Oral presentation
- 第48回日本肝癌研究会, Jul. 2012, Japanese, 日本肝癌研究会, 石川, Domestic conference進行肝細胞癌に対する経皮的肝灌流(PIHP)の手技、プロトコールと治療成績Oral presentation
- 第48回日本肝癌研究会, Jul. 2012, Japanese, 日本肝癌研究会, 石川, Domestic conference進行肝癌におけるGd-EOB-DTPA造影MRIの果たす役割Oral presentation
- 第48回日本肝癌研究会, Jul. 2012, Japanese, 日本肝癌研究会, 石川, Domestic conference診断5-3 症例Oral presentation
- 第48回日本肝癌研究会, Jul. 2012, Japanese, 日本肝癌研究会, 石川, Domestic conference診断1-3症例Oral presentation
- 第48回日本肝癌研究会, Jul. 2012, Japanese, 日本肝癌研究会, 石川, Domestic conference診断1-2 症例Oral presentation
- 第67回日本消化器外科学会総会, Jul. 2012, Japanese, 日本消化器外科学会, 富山, Domestic conference術前ERCPによる重症急性膵炎発症後手術を施行した膵頭部悪性腫瘍の検討Oral presentation
- 第67回日本消化器外科学会総会, Jul. 2012, Japanese, 日本消化器外科学会, 富山, Domestic conference左葉を用いた成人生体肝移植における残肝還流障害を回避可能な術式選択Public symposium
- 第67回日本消化器外科学会総会, Jul. 2012, Japanese, 日本消化器外科学会, 富山, Domestic conference鏡視下手術用臓器圧排器具エンドラクターの腹腔鏡下肝切除術における有用性Oral presentation
- 第67回日本消化器外科学会総会, Jul. 2012, Japanese, 日本消化器外科学会, 富山, Domestic conference肝門部胆管癌における胆管断端癌遺残例はborderline resectable症例であるPublic symposium
- 第67回日本消化器外科学会総会, Jul. 2012, Japanese, 日本消化器外科学会, 富山, Domestic conference肝胆道手術における術前シミュレーションと術中ナビゲーションの取り組みOral presentation
- 第48回日本肝癌研究会, Jul. 2012, Japanese, 日本肝癌研究会, 石川, Domestic conference肝癌手術におけるソナゾイドを用いた術中胆道造影下超音波検査の有用性Oral presentation
- 第67回日本消化器外科学会総会, Jul. 2012, Japanese, 日本消化器外科学会, 富山, Domestic conference肝癌根治的治療域の拡大:幕内基準を超えた肝切除の可能性Public symposium
- 第48回日本肝癌研究会, Jul. 2012, Japanese, 日本肝癌研究会, 石川, Domestic conference完全鏡視下肝切除における新規デバイスの活用Oral presentation
- 10th World Congress of the International Hepato-Pancreato-Biliary Association, Jul. 2012, English, IHPBA, Paris,France, International conferenceVolumetric assessment for new-onset diabetes after distal pancreatectomy in non-diabetic patientsPoster presentation
- 10th World Congress of the International Hepato-Pancreato-Biliary Association, Jul. 2012, English, IHPBA, Paris,France, International conferenceThe clinical role of positron emission tomography with F-18-fluorodexoyglucose(FDG-PET) in diagnosis and staging in patients with pancreatic ductal adenocaricinomaPoster presentation
- The 6th S.Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium, Jul. 2012, English, 高橋信次記念三次元原体照射国際学会, 広島県(広島国際会議場), Efficacly of originally established absorbant spacer was explained, International conferenceSurgically Implanted Flexible Spacer in Particle Therapy:Making Temporal Space between Tumor and Adjacent Organs!Poster presentation
- 10th World Congress of the International Hepato-Pancreato-Biliary Association, Jul. 2012, English, IHPBA, Paris,France, International conferenceOperative outcome of hepatic resection combined with portal vein resection for hilar cholangiocarcinomaPoster presentation
- 第67回日本消化器外科学会総会, Jul. 2012, Japanese, 日本消化器外科学会, 富山, Domestic conferenceIPMNに対する縮小手術の適応Public symposium
- 10th World Congress of the International Hepato-Pancreato-Biliary Association, Jul. 2012, English, IHPBA, Paris,France, International conferenceDual Treatment of Reductive Surgery and Sequential Percutaneous Isolated Hepatic Perfusion for Multiple Bilobar Hepatocellular Carcinoma Long-Term Results with a Special Focus on Major Portal Vein Tumor ThrombusOral presentation
- 24TH INTERNATIONAL CONGRESS OF THE TRANSPLANTATION SOCIETY, Jul. 2012, English, TTS, Berlin,Germany, International conferenceA case of strongly suspected acute graft-versus-host-disease following simultaneous pancreas-kidney transplants(SPK)Poster presentation
- 第67回日本消化器外科学会総会, Jul. 2012, Japanese, 日本消化器外科学会, 富山, Domestic conference80歳以上超高齢者胆道癌に対する治療成績の検討Public symposium
- 第43回日本膵臓学会大会, Jun. 2012, Japanese, 日本膵臓学会, 山形, Domestic conference膵頭十二指腸切除術後出血例に対する治療選択と成績Public symposium
- 第43回日本膵臓学会大会, Jun. 2012, Japanese, 日本膵臓学会, 山形, Domestic conference膵腫瘍に対する腹腔鏡下尾側膵切除術Public symposium
- 第34回日本癌局所療法研究会, Jun. 2012, Japanese, 日本癌局所療法研究会, 福島, Domestic conference膵癌術後肝転移に対する経皮的肝灌流化学療法(PIHP)の治療経験Oral presentation
- 第34回日本癌局所療法研究会, Jun. 2012, Japanese, 日本癌局所療法研究会, 福島, Domestic conference膵癌Gemcitabine併用陽子線療法後に発症した間質性肺炎の1例Oral presentation
- 第48回日本肝臓学会総会, Jun. 2012, Japanese, 日本肝臓学会, 石川, Domestic conference腹腔鏡下ラジオ波焼灼術におけるNon Trocar Techniqueの有用性Poster presentation
- 第30回日本肝移植研究会, Jun. 2012, Japanese, 日本肝移植研究会, 福岡, Domestic conference生体肝移植患者と移植に至らなかった患者の不適応要因Oral presentation
- 第48回日本肝臓学会総会, Jun. 2012, Japanese, 日本肝臓学会, 石川, Domestic conference進行肝細胞癌治療における経皮的肝灌流(PIHP)の位置付け〜さらなる成績の向上を目指して〜Public symposium
- 第48回日本肝臓学会総会, Jun. 2012, Japanese, 日本肝臓学会, 石川, Domestic conference神経内分泌腫瘍肝転移に対する肝切除の検討Poster presentation
- 第34回日本癌局所療法研究会, Jun. 2012, Japanese, 日本癌局所療法研究会, 福島, Domestic conference術前経皮的肝灌流と肝切除で完全奏功した両葉多発肝細胞癌の1例Oral presentation
- 第34回日本癌局所療法研究会, Jun. 2012, Japanese, 日本癌局所療法研究会, 福島, Domestic conference硬化性胆管炎合併胆管癌に化学療法を行い長期生存し得た2例Oral presentation
- 第34回日本癌局所療法研究会, Jun. 2012, Japanese, 日本癌局所療法研究会, 福島, Domestic conference肝細胞癌での遠隔転移切除を含む集学的治療を行なった1例Oral presentation
- 第30回日本肝移植研究会, Jun. 2012, Japanese, 日本肝移植研究会, 福岡, Domestic conference「生体肝移植後長期腎機能障害を予測する新たな予後因子の立案」Public symposium
- 第34回日本癌局所療法研究会, Jun. 2012, Japanese, 日本癌局所療法研究会, 福島, Domestic conferenceダブルバルーン内視鏡で確定診断し治療した術後再発胆管癌の3例Oral presentation
- 第43回日本膵臓学会大会, Jun. 2012, Japanese, 日本膵臓学会, 山形, Domestic conferenceTMN分類と腫瘍細胞増殖動態からみた膵神経内分泌腫瘍(P-NET)術後再発例の検討Oral presentation
- 第43回日本膵臓学会大会, Jun. 2012, Japanese, 日本膵臓学会, 山形, Domestic conferenceStage0ならびにStage1膵癌切除症例の検討Oral presentation
- 20th International Congress of the European Association for Endoscopic Surgery, Jun. 2012, English, EAES, Brussels,Belgium, International conferenceLaparoscopic distal pancreatectomy:Case experiences of difficultiesPoster presentation
- American Transplant Congress 2012, Jun. 2012, English, ASTS, Boston, USA, International conferenceFragility index,a novel predictor of renal function after living donor liver transplantation.Poster presentation
- The 49th Annual Meeting of Japan Society of Hepatology, Jun. 2012, Japanese, The Japan Society of Hepatology, 金沢, Domestic conferenceC型肝炎肝硬変患者に対する移植後リバビリン・インターフェロン少量長期投与の有効性Oral presentation
- 第24回日本肝胆膵外科学会・学術集会, May 2012, English, 日本肝胆膵外科学会, 大阪, Domestic conferenceLiver resection for adovanced HCC with Vp4 PVTT using back flow perfusion(BFP)technique.Public symposium
- 第24回日本肝胆膵外科学会・学術集会, May 2012, Japanese, 日本肝胆膵外科学会, 大阪, Domestic conference膵頭十二指腸切除術における安全・確実な膵空腸吻合手術手技Public symposium
- 第191回近畿外科学会, May 2012, Japanese, 近畿外科学会, 大阪, Domestic conference膵体尾部癌術後残膵癌に対し残膵全摘術を施行した1例Poster presentation
- 第24回日本肝胆膵外科学会・学術集会, May 2012, Japanese, 日本肝胆膵外科学会, 大阪, Domestic conference膵腫瘍核手術:手技の工夫と術後膵機能Poster presentation
- 第24回日本肝胆膵外科学会・学術集会, May 2012, Japanese, 日本肝胆膵外科学会, 大阪, Domestic conference膵腫瘍に対する鏡視下尾側膵切除術Poster presentation
- 第24回日本肝胆膵外科学会・学術集会, May 2012, Japanese, 日本肝胆膵外科学会, 大阪, Domestic conference膵癌術後5年目に出現した超高齢者の残膵癌に対し、粒子線治療を施行した一例Poster presentation
- 第66回手術手技研究会, May 2012, Japanese, 手術手技研究会, 福岡, Domestic conference膵炎合併例に対する膵頭十二指腸切除術 -生食滴下式バイポーラを用いた手術手技-Oral presentation
- 第24回日本肝胆膵外科学会・学術集会, May 2012, Japanese, 日本肝胆膵外科学会, 大阪, Domestic conference膵・胆管合流異常を伴わない20代の肝門部胆管癌の一切除例Poster presentation
- 第24回日本肝胆膵外科学会・学術集会, May 2012, Japanese, 日本肝胆膵外科学会, 大阪, Domestic conference腹腔鏡下胆嚢摘出術における術中胆道損傷例の特徴とその対処に関する検討[Invited]Invited oral presentation
- 第24回日本肝胆膵外科学会・学術集会, May 2012, Japanese, 日本肝胆膵外科学会, 大阪, Domestic conference腹腔鏡下ラジオ波焼灼術におけるNon Trocar Techniqueの有用性Public symposium
- 第24回日本肝胆膵外科学会・学術集会, May 2012, Japanese, 日本肝胆膵外科学会, 大阪, Domestic conference脳死下膵腎同時移植における血行再建術Public symposium
- 第191回近畿外科学会, May 2012, Japanese, 近畿外科学会, 大阪, Domestic conference肉腫成分を含む混合型肝癌の1例Poster presentation
- 第24回日本肝胆膵外科学会・学術集会, May 2012, Japanese, 日本肝胆膵外科学会, 大阪, Domestic conference肉腫成分を含む肝内胆管癌および混合型肝癌の2例Poster presentation
- 第24回日本肝胆膵外科学会・学術集会, May 2012, Japanese, 日本肝胆膵外科学会, 大阪, Domestic conference当施設におけるModified Hanging Maneuverを用いた肝葉切除の工夫Public symposium
- 第191回近畿外科学会, May 2012, Japanese, 近畿外科学会, 大阪, Domestic conference胆嚢に発生したいわゆる癌肉腫の1例Poster presentation
- 第24回日本肝胆膵外科学会・学術集会, May 2012, Japanese, 日本肝胆膵外科学会, 大阪, Domestic conference胆道再々建術施行例の背景疾患と手術成績の検討Poster presentation
- 第24回日本肝胆膵外科学会・学術集会, May 2012, Japanese, 日本肝胆膵外科学会, 大阪, Domestic conference切除例の解析からみたIPMNの治療戦略Public symposium
- 第66回手術手技研究会, May 2012, Japanese, 手術手技研究会, 福岡, Domestic conference切除困難例に対する術前経皮的肝灌流化学療法と肝切除Oral presentation
- 第24回日本肝胆膵外科学会・学術集会, May 2012, Japanese, 日本肝胆膵外科学会, 大阪, Domestic conference心血管疾患合併患者の胆嚢摘出術例の検討Poster presentation
- 第66回手術手技研究会, May 2012, Japanese, 手術手技研究会, 福岡, Domestic conference初診時非切除と判断したが、化学療法後に切除となった進行胆道癌症例の検討Oral presentation
- 第24回日本肝胆膵外科学会・学術集会, May 2012, Japanese, 日本肝胆膵外科学会, 大阪, Domestic conference肝門部胆管癌門脈合併切除例の検討Public symposium
- 第191回近畿外科学会, May 2012, Japanese, 近畿外科学会, 大阪, Domestic conference肝細胞癌術後リンパ節再発による胃浸潤を来した一例Poster presentation
- 第24回日本肝胆膵外科学会・学術集会, May 2012, Japanese, 日本肝胆膵外科学会, 大阪, Domestic conference肝細胞癌における術式選択;幕内基準を超えてPublic symposium
- 第24回日本肝胆膵外科学会・学術集会, May 2012, English, 日本肝胆膵外科学会, 大阪, Domestic conferencePylorus-preserving pancreaticoduodenectomyPublic symposium
- 第24回日本肝胆膵外科学会・学術集会, May 2012, English, 日本肝胆膵外科学会, 大阪, Domestic conferenceLiving Donor Liver Transplantation with Portal Vein Thrombus;Portal Vein Reconstruction Technique using Left Gastic Vein.Public symposium
- 第191回近畿外科学会, May 2012, Japanese, 近畿外科学会, 大阪, Domestic conferenceIPMN経過観察中に発生した膵頭部進行癌の1切除例Poster presentation
- 日本超音波医学会第85回学術集会, May 2012, Japanese, 日本超音波医学会, 東京, Domestic conferenceEPSガイド下に腫瘍核出術を施行し得た膵頭部 Solid-pseudopapillary neoplasm の1例Oral presentation
- 第24回日本肝胆膵外科学会・学術集会, May 2012, Japanese, 日本肝胆膵外科学会, 大阪, Domestic conferenceCT所見とERC/IDUS所見の乖離により診断に難渋した進行胆嚢癌疑いの1例Public symposium
- 第24回日本肝胆膵外科学会・学術集会, May 2012, Japanese, 日本肝胆膵外科学会, 大阪, Domestic conferenceBorderline resectable膵癌切除例の検討と今後の展望Public symposium
- APCCVIR 2012 JSIR&ISIR, May 2012, English, JSIR, 神戸, International conferenceA novel chemo-surgical treatment for advanced hepatocellular carcionoma with percutaneous isolated hepatic perfusion (PIHP)Public symposium
- 第112回日本外科学会定期学術集会, Apr. 2012, Japanese, 日本外科学会, 千葉, Domestic conference膵癌術後補助化学療法の再検討と課題Poster presentation
- 第98回日本消化器病学会総会, Apr. 2012, Japanese, 日本消化器病学会, 東京, Domestic conference両葉多発肝細胞癌に対する経的肝灌流化学療法を軸とした集学的治療Public symposium
- 第112回日本外科学会定期学術集会, Apr. 2012, Japanese, 日本外科学会, 千葉, Domestic conference尾側膵切除後糖尿病の危険因子の解析Oral presentation
- 第112回日本外科学会定期学術集会, Apr. 2012, Japanese, 日本外科学会, 千葉, Domestic conference非切除胆道癌に対し化学療法施行後に切除に至った症例の検討Public symposium
- 第112回日本外科学会定期学術集会, Apr. 2012, Japanese, 日本外科学会, 千葉, Domestic conference中上部胆管癌に対する胆管切除の検討Poster presentation
- 第112回日本外科学会定期学術集会, Apr. 2012, Japanese, 日本外科学会, 千葉, Domestic conference胆嚢摘出時における術中胆道造影の意義Poster presentation
- 第112回日本外科学会定期学術集会, Apr. 2012, Japanese, 日本外科学会, 千葉, Domestic conference代謝酵素測定による胆道癌術後 GEM 補助投与の効果予測の検討Oral presentation
- 第112回日本外科学会定期学術集会, Apr. 2012, Japanese, 日本外科学会, 千葉, Domestic conference生体肝移植後腎機能障害に対する予測式を用いた新たな治療戦略Oral presentation
- 第112回日本外科学会定期学術集会, Apr. 2012, Japanese, 日本外科学会, 千葉, Domestic conference主膵管近接腫瘍に対する膵腫瘍核出術の適応と手術手技の工夫Oral presentation
- 第112回日本外科学会定期学術集会, Apr. 2012, Japanese, 日本外科学会, 千葉, Domestic conference高度進行肝癌に対する減量肝切除と PIHP による 2 段階治療の有効性と予後因子の解析Public symposium
- 第98回日本消化器病学会総会, Apr. 2012, Japanese, 日本消化器病学会, 東京, Domestic conferenceIPMN 外科治療における縮小手術の位置づけOral presentation
- 第112回日本外科学会定期学術集会, Apr. 2012, Japanese, 日本外科学会, 千葉, Domestic conference-Others
- 第14回関西肝癌局所療法研究会, Mar. 2012, Japanese, 関西肝癌局所療法研究会, 大阪, Domestic conference腹腔鏡下ラジオ派焼灼術におけるNon Trocar Technique(NTT法)の有用性Oral presentation
- 第48回腹部救急医学会総会, Mar. 2012, Japanese, 日本腹部救急医学会, 石川, Domestic conference腸回転異常症に伴う回盲部軸捻転の1 例Oral presentation
- 第48回腹部救急医学会総会, Mar. 2012, Japanese, 日本腹部救急医学会, 石川, Domestic conference抗凝固薬内服患者に対する腹腔鏡下胆嚢摘出術施行例の検討Oral presentation
- 第48回腹部救急医学会総会, Mar. 2012, Japanese, 日本腹部救急医学会, 石川, Domestic conference急性胆嚢炎、胆汁性腹膜炎の術前診断で緊急手術を施行したうっ血性肝障害の1 例Oral presentation
- 第48回腹部救急医学会総会, Mar. 2012, Japanese, 日本腹部救急医学会, 石川, Domestic conference肝門部胆管癌術後仮性動脈瘤出血の1 例Oral presentation
- 第16回 兵庫粒子線治療研究会, Mar. 2012, Japanese, 神戸, Domestic conference「新開発した生体吸収性スペーサーの基礎的検討」Oral presentation
- 第39回日本膵・膵島移植研究会, Mar. 2012, Japanese, 日本膵・膵島移植研究会, 旭川, Domestic conferenceグラフト脾動静脈および上腸間膜動脈に血栓形成をきたした膵腎同時移植の1例Oral presentation
- 5th International Forum of Liver Surgery Akita 2012, Mar. 2012, English, International Forum of Liver Surgery, 秋田, Domestic conferenceFeasibility to use a newly-developed Endoractor for laparoscopic hepatectomy.Oral presentation
- 5th International Forum of Liver Surgery Akita 2012, Mar. 2012, English, International Forum of Liver Surgery, 秋田, Domestic conferenceFailure of fibrotic liver regeneration in mice is linked to severe fibrogenic response driven by hepatic progenitor cell activation.Oral presentation
- 第48回腹部救急医学会総会, Mar. 2012, Japanese, 日本腹部救急医学会, 石川, Domestic conferenceERCP後重症急性膵炎を併発した胆管癌に対し膵頭十二指腸切除術後、特異な再発形態を呈した1 例Oral presentation
- 第5回神戸肝胆膵研究会, Mar. 2012, Japanese, 日本腹部救急医学会, 神戸, Domestic conference-Public symposium
- 第40回近畿肝臓外科研究会, Feb. 2012, Japanese, 近畿肝臓外科研究会, 大阪, Domestic conference大血管侵襲を伴う肝細胞癌に対する肝切除Oral presentation
- 第40回近畿肝臓外科研究会, Feb. 2012, Japanese, 近畿肝臓外科研究会, 大阪, Domestic conference-Public symposium
- 第2回阪神腫瘍外科研究会, Jan. 2012, Japanese, 阪神腫瘍外科研究会, 大阪, Domestic conference-Public symposium
- 第24回日本内視鏡外科学会総会, Dec. 2011, Japanese, 日本内視鏡外科学会, 大阪, Domestic conference遊走胆嚢に対して単孔式腹腔鏡下胆摘出術を施行した1例Oral presentation
- 第24回日本内視鏡外科学会総会, Dec. 2011, Japanese, 日本内視鏡外科学会, 大阪, Domestic conference腹腔鏡補助下膵体尾部切除術Oral presentation
- 第24回日本内視鏡外科学会総会, Dec. 2011, Japanese, 日本内視鏡外科学会, 大阪, Domestic conference腹腔鏡下膵切除術における適応と手技Oral presentation
- 第24回日本内視鏡外科学会総会, Dec. 2011, Japanese, 日本内視鏡外科学会, 大阪, Domestic conference腹腔鏡下膵腫瘍核手術を施行したindeterminate mucin-producing cystic neoplasmの1例Oral presentation
- 第24回日本内視鏡外科学会総会, Dec. 2011, Japanese, 日本内視鏡外科学会, 大阪, Domestic conference腹腔鏡下胆嚢摘出術時の術中胆道造影の成績の検討~開腹胆嚢摘出術と比較して~Oral presentation
- 第24回日本内視鏡外科学会総会, Dec. 2011, Japanese, 日本内視鏡外科学会, 大阪, Domestic conference新規臓器圧排用具エンドラクターの腹腔鏡下肝切除術における有用性Oral presentation
- 第39回日本肝臓学会西部会, Dec. 2011, Japanese, 日本肝臓学会, 岡山, Domestic conference血管造影下CT,SPIO MRIが診断に有効であった微小結節転移性カルチノイド肝腫瘍の一例Poster presentation
- 第39回日本肝臓学会西部会, Dec. 2011, Japanese, 日本肝臓学会, 岡山, Domestic conference血管造影下CT , SPIO MRI が診断に有効であった転移性肝カルチノイド微小結節の一例Poster presentation
- 第28回近畿肝移植検討会, Dec. 2011, Japanese, 近畿肝移植検討会, 大阪, Domestic conference肝移植後C肝炎再発に対するリハビリン・インターフェロン少量投与の長期経過Oral presentation
- 第39回日本肝臓学会西部会, Dec. 2011, Japanese, 日本肝臓学会, 岡山, Domestic conference外科切除術における非B非C肝細胞癌の検討Public symposium
- 第24回日本内視鏡外科学会総会, Dec. 2011, Japanese, 日本内視鏡外科学会, 大阪, Domestic conferenceIPMNに対する腹腔鏡手術の適応Oral presentation
- 第40回日本肝臓学会西部会, Dec. 2011, Japanese, 日本肝臓学会, 岡山, Domestic conference10日前退院時は健常であったが、再入院後2日間の経過で電撃的経過をたどった急性肝不全の一剖検例―原因検索を中心にPoster presentation
- 第73回日本臨床外科学会総会, Nov. 2011, Japanese, 日本臨床外科学会, 東京, Domestic conference膵頭部IPMCに膵体尾部の上皮内癌を合併し膵全摘を施行した1例Poster presentation
- 第73回日本臨床外科学会総会, Nov. 2011, Japanese, 日本臨床外科学会, 東京, Domestic conference膵腫瘍核出術-主膵管近接例への工夫と手術手技Oral presentation
- 第73回日本臨床外科学会総会, Nov. 2011, Japanese, 日本臨床外科学会, 東京, Domestic conference膵癌との鑑別を要した自己免疫性膵炎症例の検討Oral presentation
- 第73回日本臨床外科学会総会, Nov. 2011, Japanese, 日本臨床外科学会, 東京, Domestic conference卵巣様間質を欠きIndeterminate mucin-producing cystic neoplasm と診断した膵腫瘍の1例Oral presentation
- 第73回日本臨床外科学会総会, Nov. 2011, Japanese, 日本臨床外科学会, 東京, Domestic conference腹腔鏡下膵体尾部切除術における術中出血への対策Oral presentation
- 第73回日本臨床外科学会総会, Nov. 2011, Japanese, 日本臨床外科学会, 東京, Domestic conference微小浸潤癌までの分枝型IPMNに対する術前診断と術式選択Oral presentation
- 第73回日本臨床外科学会総会, Nov. 2011, Japanese, 日本臨床外科学会, 東京, Domestic conference脳死下膵臓同時移植における血行再建術Oral presentation
- 第73回日本臨床外科学会総会, Nov. 2011, Japanese, 日本臨床外科学会, 東京, Domestic conference肉腫様変化を伴う肝内胆管癌の一切除術Oral presentation
- 第73回日本臨床外科学会総会, Nov. 2011, Japanese, 日本臨床外科学会, 東京, Domestic conference当科における膵胆管合流異常に対する手術成績の検討Oral presentation
- 第73回日本臨床外科学会総会, Nov. 2011, Japanese, 日本臨床外科学会, 東京, Domestic conference当院における単孔式腹腔鏡下胆嚢摘出術の導入と成績Oral presentation
- 第73回日本臨床外科学会総会, Nov. 2011, Japanese, 日本臨床外科学会, 東京, Domestic conference胆管癌に対する肝外胆管切除例の成績Oral presentation
- 第24回日本放射線腫瘍学会, Nov. 2011, Japanese, 日本放射線腫瘍学会, 神戸ポートピアホテル(神戸市), Domestic conference体内スペーサーの生体反応と線量分布最適化の研究Oral presentation
- 第73回日本臨床外科学会総会, Nov. 2011, Japanese, 日本臨床外科学会, 東京, Domestic conference診断までに4年間の経過を追えた胆嚢癌の1切除例Poster presentation
- 第190回近畿外科学会, Nov. 2011, Japanese, 近畿外科学会, 大阪, Domestic conference診断に難渋した、門脈閉塞を伴う胆嚢癌の1例Oral presentation
- 第73回日本臨床外科学会総会, Nov. 2011, Japanese, 日本臨床外科学会, 東京, Domestic conference小腸転移により出血性の継続的な出血を認めた肝細胞癌の1例Oral presentation
- 第73回日本臨床外科学会総会, Nov. 2011, Japanese, 日本臨床外科学会, 東京, Domestic conference高度脈管浸潤を伴う進行肝癌に対する治療戦略Oral presentation
- 第73回日本臨床外科学会総会, Nov. 2011, Japanese, 日本臨床外科学会, 東京, Domestic conference局所進行膵癌における術前診断と切除例についての検討Oral presentation
- 第73回日本臨床外科学会総会, Nov. 2011, Japanese, 日本臨床外科学会, 東京, Domestic conference局所進行癌における術前診断と切除例についての検討Oral presentation
- 第190回近畿外科学会, Nov. 2011, Japanese, 近畿外科学会, 大阪, Domestic conference急性胆嚢炎の術前診断で緊急手術を執行したうっ血性肝障害の1例Oral presentation
- 第190回近畿外科学会, Nov. 2011, Japanese, 近畿外科学会, 大阪, Domestic conference肝血管筋脂肪腫の1例Oral presentation
- 第190回近畿外科学会, Nov. 2011, Japanese, 近畿外科学会, 大阪, Domestic conference悪性リンパ腫加療中に鑑別を要した膵頭部IPMNの1例Oral presentation
- The 62st Annual Meeting of the American Association for the Study of Liver Diseases (AASLD), Nov. 2011, English, American Association for the Study of Liver Diseases, サンフランシスコ, アメリカ合衆国, International conferencePrecutaneous isolated hepatic perfusion(PIHP)for advanced hepatocellular carcinoma:20 years experience.Poster presentation
- 21st World Congress of the International Association of Surgeons Gastroenterologists and Oncologists(IASGO), Nov. 2011, English, The International Association of Surgeons, Gastroenterologists and Oncologists, 東京, Domestic conferenceLaparoscopic cholecystectomy in patient cirrhotic.Poster presentation
- 第73回日本臨床外科学会総会, Nov. 2011, Japanese, 日本臨床外科学会, 東京, Domestic conferenceFrey手術における膵管空腸側々吻合Oral presentation
- 21st World Congress of the International Association of Surgeons Gastroenterologists and Oncologists(IASGO), Nov. 2011, English, The International Association of Surgeons, Gastroenterologists and Oncologists, 東京, Domestic conferenceDiagnosis and treatment of strategy of pancreatic neuroendocrine tumor.Oral presentation
- 21st World Congress of the International Association of Surgeons Gastroenterologists and Oncologists(IASGO), Nov. 2011, English, The International Association of Surgeons, Gastroenterologists and Oncologists, 東京, Domestic conferenceA new methot for preoperative assessment of the difficulty of laparoscopic cholecystectomy using lier bed pocket score.Oral presentation
- The 62st Annual Meeting of the American Association for the Study of Liver Diseases (AASLD), Nov. 2011, English, American Association for the Study of Liver Diseases, サンフランシスコ, アメリカ合衆国, International conference664 Renal function deteriorates after living donor liver transplanation how to predict chronic dysfunction?Poster presentation
- 第10回神戸胆膵疾患研究会, Nov. 2011, Japanese, 神戸胆膵疾患研究会, 神戸, Domestic conference20代の肝門部胆管癌に根治切除を施行した1例Oral presentation
- 第60回近畿膵疾患談話会, Oct. 2011, Japanese, 近畿膵疾患談話会, 大阪, Domestic conference膵癌に対する粒子線治療の導入とその可能性Oral presentation
- JDDW 2011 (Japan Digestive Disease Week 2011) 第19 回日本消化器関連学会週間(第15回日本肝臓学会大会), Oct. 2011, Japanese, 日本消化器関連学会機構, 福岡, Domestic conference両葉多発肝細部癌に対する集学的治療Oral presentation
- 第49回日本癌治療学会学術集会, Oct. 2011, Japanese, 日本癌治療学会, 名古屋, Domestic conference粒子線治療を用いた膵癌に対する新しい治療戦略Oral presentation
- 第47回日本移植学会総会, Oct. 2011, Japanese, 日本移植学会総会, 仙台, Domestic conference生体膵移植ガイドラインを用いた尾側膵切除後の耐糖能の検討Oral presentation
- 第47回日本移植学会総会, Oct. 2011, Japanese, 日本移植学会総会, 仙台, Domestic conference生体肝移植後長期の腎機能予測式Oral presentation
- JDDW 2011 (Japan Digestive Disease Week 2011) 第19 回日本消化器関連学会週間(消化器外科学会), Oct. 2011, Japanese, 日本消化器関連学会機構, 福岡, Domestic conference神経内分泌腫瘍肝転移に対する肝切除の意義Poster presentation
- JDDW 2011 (Japan Digestive Disease Week 2011) 第19 回日本消化器関連学会週間(消化器外科学会), Oct. 2011, Japanese, 日本消化器関連学会機構, 福岡, Domestic conference十二指腸内に急速に発育進展した胆管原発癌肉腫の1切除例Poster presentation
- JDDW 2011 (Japan Digestive Disease Week 2011) 第19 回日本消化器関連学会週間(消化器外科学会), Oct. 2011, Japanese, 日本消化器関連学会機構, 福岡, Domestic conference高齢者に対する膵頭十二指腸切除術後合併症についての検討Poster presentation
- JDDW 2011 (Japan Digestive Disease Week 2011) 第19 回日本消化器関連学会週間(消化器外科学会), Oct. 2011, Japanese, 日本消化器関連学会機構, 福岡, Domestic conference肝内胆管癌と粘液産生胆管腫瘍におけるCD133発現の意義についてPoster presentation
- 第14回近畿外科病態研究会, Oct. 2011, Japanese, 近畿外科病態研究会, 大阪, Domestic conference「膵頭十二指腸切除術後、門脈閉塞を合併する仮性動脈瘤破裂に対し、門脈ステント留置とTAEを同時に行い救命し得た一例」Oral presentation
- JDDW 2011 (Japan Digestive Disease Week 2011) 第19 回日本消化器関連学会週間(消化器外科学会), Oct. 2011, Japanese, 日本消化器関連学会機構, 福岡, Domestic conferenceB型・C型肝炎を合併した肝門部胆管癌切除例の検討Poster presentation
- 第47回日本移植学会総会, Oct. 2011, Japanese, 日本移植学会総会, 仙台, Domestic conference0 HLA antigen mismatched donor による脳死膵腎同時移植(SPK)後、GVHDが強く疑われている1例Oral presentation
- 第14回近畿外科病態研究会, Oct. 2011, Japanese, 近畿外科病態研究会, 大阪, Domestic conference-Public symposium
- 第65回手術手技研究会, Sep. 2011, Japanese, 手術手技研究会, 東京, Domestic conference膵腫瘍核出術~主膵管近接例に対する工夫と功績~Oral presentation
- 第34回日本膵・胆管合流異常研究会, Sep. 2011, Japanese, 日本膵・胆管合流異常研究会, 山梨, Domestic conference当科における膵・胆管合流異常に合併した胆道癌症例検討Oral presentation
- 第47回日本胆道学会学術集会, Sep. 2011, Japanese, 日本胆道学会学, 宮崎, Domestic conference胆嚢床および腹壁への浸潤が疑われ胆嚢癌との鑑別を要した黄色肉芽腫性胆嚢炎の1例Poster presentation
- 第47回日本胆道学会学術集会, Sep. 2011, Japanese, 日本胆道学会学, 宮崎, Domestic conference多時再発を示した巨大総胆管結石症の一手術例Poster presentation
- Asian Pacific HPBA Congress 2011 3rd Biennial Congress, Sep. 2011, English, Hepato Pancreato Biliary Association, メルボルン, オーストラリア, International conferenceValue of three-dimensional direct multi-detector row CT cholangiography in biliary ductal evaluation for perihilar cholangiocarcinoma.Poster presentation
- 12th Congress of the Asian Society of Transplantation (CAST 2011), Sep. 2011, English, Asian Society of Transplantation, ソウル, 大韓民国, International conferencePrediction of renal function after living donor liver transplantaion.Oral presentation
- International Liver Cancer Association Fifth Annual Conference (ILCA), Sep. 2011, English, International Liver Cancer Association, 香港, 香港, International conferencePercutaneous isolated hepatic perfusion (PIHP) for advanced hepatocellular carcinoma: 20 years experience.Poster presentation
- Asian Pacific HPBA Congress 2011 3rd Biennial Congress, Sep. 2011, English, Hepato Pancreato Biliary Association, メルボルン, オーストラリア, International conferenceIntraoperative cholangiography is valuable for cholecystomy in patients treated by preoperative endoscopic stone removal for choledocholithiasis.Poster presentation
- Joint Meeting of the 4th Asian-Oceanic Pancreas Association and 2011 Annual Congress of the Korean Pancreatobiliary Association (AOPA & KPBA), Sep. 2011, English, Korean Pancreatobiliary Association and Korean Pancreas Surgery Club, 済州島, 大韓民国, International conferenceEvaluation of pancreatic endocrine function after distal pancreatectomy.Poster presentation
- International Liver Cancer Association Fifth Annual Conference (ILCA), Sep. 2011, English, International Liver Cancer Association, 香港, 香港, International conferenceDual treatment; a novel strategy for highly-adovanced hepatocellular carcinoma.Poster presentation
- Joint Meeting of the 4th Asian-Oceanic Pancreas Association and 2011 Annual Congress of the Korean Pancreatobiliary Association (AOPA & KPBA), Sep. 2011, English, Korean Pancreatobiliary Association and Korean Pancreas Surgery Club, 済州島, 大韓民国, International conferenceDistinguishing pancreatic cancer from autoimmune pancreatitis:analysis of 7 cases.Poster presentation
- Asian Pacific HPBA Congress 2011 3rd Biennial Congress, Sep. 2011, English, Hepato Pancreato Biliary Association, メルボルン, オーストラリア, International conferenceDifferent CD133 expression pattern of intraductal papillary neoplasms of bile duct (IPNB) and biliary tract adoenocarcinomas.Poster presentation
- International Liver Cancer Association Fifth Annual Conference (ILCA), Sep. 2011, English, International Liver Cancer Association, 香港, 香港, International conferenceCombined strategy of surgical spacer placement with proton radiothrerapy for the treatment of hepatocellular carcinoma.Poster presentation
- Asian Pacific HPBA Congress 2011 3rd Biennial Congress, Sep. 2011, English, Hepato Pancreato Biliary Association, メルボルン, オーストラリア, International conferenceBiliary re-reconstruction in patients with biliary disease.Poster presentation
- 12th Congress of the Asian Society of Transplantation (CAST 2011), Sep. 2011, English, Asian Society of Transplantation, ソウル, 大韓民国, International conferenceA case report of severePTLD after LDLT.Poster presentation
- 日本消化器病学会近畿支部 第95回例会, Aug. 2011, Japanese, 日本消化器病学会, 大阪, Domestic conference膵腫瘍核出術-当科における工夫‐Others
- 第38回日本膵切除研究会, Aug. 2011, Japanese, 日本膵切除研究会, 久留米, Domestic conference膵癌に対する化学療法併用粒子線治療の導入Oral presentation
- 第38回日本膵切除研究会, Aug. 2011, Japanese, 日本膵切除研究会, 久留米, Domestic conference腹腔鏡下膵体尾部切除術の手技と成績Oral presentation
- 第47回日本腹部救急医学会総会, Aug. 2011, Japanese, 日本腹部救急医学会, 福岡, Domestic conference当科における急性胆嚢炎に対する緊急手術Poster presentation
- 第47回日本腹部救急医学会総会, Aug. 2011, Japanese, 日本腹部救急医学会, 福岡, Domestic conference胆管癌における術前ドレナージ中の胆管炎発症例の検討Public symposium
- 日本消化器病学会近畿支部 第95回例会, Aug. 2011, Japanese, 日本消化器病学会, 大阪, Domestic conference進行肝細胞癌に対すPIHPを軸とした治療戦略Oral presentation
- 第47回日本腹部救急医学会総会, Aug. 2011, Japanese, 日本腹部救急医学会, 福岡, Domestic conference十二指腸切除後肝動脈関連出血動脈出血症例の検討Oral presentation
- 第66回日本消化器外科学会総会, Jul. 2011, Japanese, 日本消化器外科学会, 名古屋, Domestic conference膵頭十二指腸切除術後出血の臨床経過の解析と出血時のマネージメントOral presentation
- 第66回日本消化器外科学会総会, Jul. 2011, Japanese, 日本消化器外科学会, 名古屋, Domestic conference膵臓幹細胞を標的とした新規治療法の開発Oral presentation
- 第42回日本膵臓学会大会, Jul. 2011, Japanese, 日本膵臓学会, 青森, Domestic conference膵癌診断におけるFDG-PETの役割Oral presentation
- 第42回日本膵臓学会大会, Jul. 2011, Japanese, 日本膵臓学会, 青森, Domestic conference膵癌に対する粒子線治療効果判定におけるFDG-PETの有用性Oral presentation
- 第66回日本消化器外科学会総会, Jul. 2011, Japanese, 日本消化器外科学会, 名古屋, Domestic conference膵癌に対する粒子線治療Oral presentation
- 第66回日本消化器外科学会総会, Jul. 2011, Japanese, 日本消化器外科学会, 名古屋, Domestic conference陽子線治療にてVp4門脈腫瘍栓を制御後、経皮的肝灌流化学療法(PIHP)を施行した1例Oral presentation
- 第66回日本消化器外科学会総会, Jul. 2011, Japanese, 日本消化器外科学会, 名古屋, Domestic conference末梢型肝内胆管癌の手術成績からみた治療戦略Oral presentation
- 第66回日本消化器外科学会総会, Jul. 2011, Japanese, 日本消化器外科学会, 名古屋, Domestic conference腹腔鏡下膵体尾部切除術‐適応と手術手技‐Oral presentation
- 第47回日本肝癌研究会, Jul. 2011, Japanese, 日本肝癌研究会, 静岡, Domestic conference当施設における肝切除の適応および限界-腹腔鏡下から腫瘍栓摘出まで-Oral presentation
- 第47回日本肝癌研究会, Jul. 2011, Japanese, 日本肝癌研究会, 静岡, Domestic conference当科における肝細胞切除後長期無再発症例の検討Poster presentation
- 第66回日本消化器外科学会総会, Jul. 2011, Japanese, 日本消化器外科学会, 名古屋, Domestic conference胆嚢の肝臓への埋まり込みスコアによる腹腔鏡下胆嚢摘出術の術前難易度評価Oral presentation
- 第66回日本消化器外科学会総会, Jul. 2011, Japanese, 日本消化器外科学会, 名古屋, Domestic conference進行胆道癌に対する術後補助化学療法の成績と課題Public symposium
- 第47回日本肝癌研究会, Jul. 2011, Japanese, 日本肝癌研究会, 静岡, Domestic conference新規臓器圧排用器具エンドラクターの腹鏡下肝切除術における有用性Poster presentation
- 第47回日本肝癌研究会, Jul. 2011, Japanese, 日本肝癌研究会, 静岡, Domestic conference自然退縮を来した肝細胞癌の3切除例Poster presentation
- 第66回日本消化器外科学会総会, Jul. 2011, Japanese, 日本消化器外科学会, 名古屋, Domestic conference高度脈管侵襲陽性肝細胞癌に対する神戸二段階療法を機軸とする集学的治療Oral presentation
- 第11回関西肝血流動態イメージ研究会, Jul. 2011, Japanese, 関西肝血流動態イメージ研究会, 大阪, Domestic conference血管造影下CT , SPIO MRI が診断に有効であった微小結節転移性カルチノイド肝腫瘍の一例Oral presentation
- 第42回日本膵臓学会大会, Jul. 2011, Japanese, 日本膵臓学会, 青森, Domestic conference癌幹細胞癌を目的とした初代膵癌幹細胞株の樹立Oral presentation
- 第66回日本消化器外科学会総会, Jul. 2011, Japanese, 日本消化器外科学会, 名古屋, Domestic conference肝門部胆管癌に対する術前画像診断についての検討Oral presentation
- 第47回日本肝癌研究会, Jul. 2011, Japanese, 日本肝癌研究会, 静岡, Domestic conference外科切除成績からみた非B非C型肝癌の実態と特徴Poster presentation
- 第29回日本肝移植研究会, Jul. 2011, Japanese, 日本肝移植研究会, 仙台, Domestic conference「生体肝移植後腎機能障害に対する新たな治療戦略」Oral presentation
- 第11回関西肝血流動態イメージ研究会, Jul. 2011, Japanese, 関西肝血流動態イメージ研究会, 大阪, Domestic conference「ソラフェニブ長期投与例における腫瘍血行動態」Public symposium
- 第66回日本消化器外科学会総会, Jul. 2011, Japanese, 日本消化器外科学会, 名古屋, Domestic conferenceVp4門脈腫瘍栓を合併した肝細胞癌における術前肝予備能評価の再孝Oral presentation
- 第66回日本消化器外科学会総会, Jul. 2011, Japanese, 日本消化器外科学会, 名古屋, Domestic conferencess胆嚢癌手術症例の検討[Invited]Invited oral presentation
- The 2nd Asia-Pacific Primary Liver Cancer Expert Meeting 2011 (APPLE), Jul. 2011, English, ASIA- PACIFIC PRIMARY LIVER CANCER EXPERT, 大阪, Domestic conferenceSignificant ole of Reductive Surgery for patients with Huge Hepatocellular Carcinoma.Poster presentation
- 第66回日本消化器外科学会総会, Jul. 2011, Japanese, 日本消化器外科学会, 名古屋, Domestic conferenceIPMNに対する腹腔鏡下膵体尾部切除術の適応Oral presentation
- The 2nd Asia-Pacific Primary Liver Cancer Expert Meeting 2011 (APPLE), Jul. 2011, English, ASIA- PACIFIC PRIMARY LIVER CANCER EXPERT, 大阪, Domestic conferenceFeasibility to use a newly-developed Endoractor for laparoscopic hepatectomy.Poster presentation
- 第189回近畿外科学会, Jun. 2011, Japanese, 近畿外科学会, 大阪, Domestic conference膵鉤部内分泌腫瘍に対して核出術を施行した1例Oral presentation
- 第23回日本肝胆膵外科学会・学術集会, Jun. 2011, Japanese, 日本肝胆膵外科学会, 東京, Domestic conference膵頭十二指腸切除術における膵液瘻のリスク因子解析Oral presentation
- 第23回日本肝胆膵外科学会・学術集会, Jun. 2011, Japanese, 日本肝胆膵外科学会, 東京, Domestic conference膵頭十二指腸切除後の門脈閉塞・仮性動脈瘤破裂に対して、門脈ステント留置とTEAにより救命し得た一例Public symposium
- 第23回日本肝胆膵外科学会・学術集会, Jun. 2011, Japanese, 日本肝胆膵外科学会, 東京, Domestic conference膵癌切除率向上を目指した膵頭十二指腸切除術における肝動脈・門脈同時合併切除再建術手技Oral presentation
- 第23回日本肝胆膵外科学会・学術集会, Jun. 2011, Japanese, 日本肝胆膵外科学会, 東京, Domestic conference両葉多発肝細部癌に対する治療戦略~神戸二段階療法Oral presentation
- 第23回日本肝胆膵外科学会・学術集会, Jun. 2011, Japanese, 日本肝胆膵外科学会, 東京, Domestic conference陽子線治療にてVp4門脈腫瘍栓を制御後、経皮的肝灌流化学療法(PIHP)を施行した1例Poster presentation
- 第23回日本肝胆膵外科学会・学術集会, Jun. 2011, Japanese, 日本肝胆膵外科学会, 東京, Domestic conference慢性膵炎に対して施行したFrey手術18例の検討Oral presentation
- 第23回日本肝胆膵外科学会・学術集会, Jun. 2011, Japanese, 日本肝胆膵外科学会, 東京, Domestic conference腹腔鏡下膵切除術の適応と手術の実態Oral presentation
- 第33回日本癌局所療法研究会, Jun. 2011, Japanese, 日本癌局所療法研究会, 大阪, Domestic conference肺癌肝転移の診断でRFAを施行するも再発した肝内胆管癌の1例Oral presentation
- 第23回日本肝胆膵外科学会・学術集会, Jun. 2011, Japanese, 日本肝胆膵外科学会, 東京, Domestic conference当科におけるcT2胆嚢癌切除術例の検討Oral presentation
- 第23回日本肝胆膵外科学会・学術集会, Jun. 2011, Japanese, 日本肝胆膵外科学会, 東京, Domestic conference著名な肝外発育をきたした重量8kgを超える巨大肝細胞癌の一切除例Poster presentation
- 第23回日本肝胆膵外科学会・学術集会, Jun. 2011, Japanese, 日本肝胆膵外科学会, 東京, Domestic conference胆管炎を合併する胆管癌切除における問題点Oral presentation
- 第189回近畿外科学会, Jun. 2011, Japanese, 近畿外科学会, 大阪, Domestic conference胆管印環細胞癌の1切除例Oral presentation
- 第23回日本肝胆膵外科学会・学術集会, Jun. 2011, Japanese, 日本肝胆膵外科学会, 東京, Domestic conference大腸癌肝転移における術前化学療法後の肝切術Poster presentation
- 第23回日本肝胆膵外科学会・学術集会, Jun. 2011, Japanese, 日本肝胆膵外科学会, 東京, Domestic conference石灰化を伴い腹部レントゲンで偶発的に発見された胆嚢内多発癌肉腫の一例Poster presentation
- 第23回日本肝胆膵外科学会・学術集会, Jun. 2011, Japanese, 日本肝胆膵外科学会, 東京, Domestic conference正確な術前・術中診断によるIPMNの術式選択Oral presentation
- 第23回日本肝胆膵外科学会・学術集会, Jun. 2011, Japanese, 日本肝胆膵外科学会, 東京, Domestic conference重症急性膵炎後の中下部胆管癌手術症例の検討Oral presentation
- 第23回日本肝胆膵外科学会・学術集会, Jun. 2011, Japanese, 日本肝胆膵外科学会, 東京, Domestic conference十二指腸乳頭部癌切除症例の検討Oral presentation
- 第23回日本肝胆膵外科学会・学術集会, Jun. 2011, Japanese, 日本肝胆膵外科学会, 東京, Domestic conference若年者の進行性粘液産生肝内胆管癌の1例Poster presentation
- 第23回日本肝胆膵外科学会・学術集会, Jun. 2011, Japanese, 日本肝胆膵外科学会, 東京, Domestic conference肝門部胆管癌手術成績から見た治療成績の工夫Oral presentation
- 第23回日本肝胆膵外科学会・学術集会, Jun. 2011, Japanese, 日本肝胆膵外科学会, 東京, Domestic conference化学療法で手術が可能になった胆嚢癌症例の検討Poster presentation
- 19th International Congress of the European Association for Endoscopic Surgery (EAES), Jun. 2011, English, European Association for Endoscopic Surgery, トリノ, イタリア, International conferenceA novel sponge device and its modification for the displacement of organs during endoscopic surgery.Oral presentation
- 第111回日本外科学会定期学術集会, May 2011, Japanese, 日本外科学会, 紙上開催, Domestic conference膵頭十二指腸切除術後肝動脈出血の臨床経過とマネージメントPoster presentation
- 第111回日本外科学会定期学術集会, May 2011, Japanese, 日本外科学会, 紙上開催, Domestic conference膵腫瘍核手術の手技と成績Poster presentation
- 第97回日本消化器病学会総会, May 2011, Japanese, 日本消化器病学会, 東京, Domestic conference膵癌幹細胞を標的とした新規治療法の開発Oral presentation
- 第97回日本消化器病学会総会, May 2011, Japanese, 日本消化器病学会, 東京, Domestic conference両葉多発肝細胞癌に対する治療戦略Oral presentation
- 第97回日本消化器病学会総会, May 2011, Japanese, 日本消化器病学会, 東京, Domestic conference粒子線治療を用いた新しい膵癌治療戦略Oral presentation
- 第111回日本外科学会定期学術集会, May 2011, Japanese, 日本外科学会, 紙上開催, Domestic conference内視鏡外科をとりまく手術環境の整備-当院での取り組みについてPoster presentation
- 第97回日本消化器病学会総会, May 2011, Japanese, 日本消化器病学会, 東京, Domestic conference当科における膵内分泌腫瘍に対する治療成績Oral presentation
- 第111回日本外科学会定期学術集会, May 2011, Japanese, 日本外科学会, 紙上開催, Domestic conference胆道再建術に対する胆道再々建術の検討Poster presentation
- 第111回日本外科学会定期学術集会, May 2011, Japanese, 日本外科学会, 紙上開催, Domestic conference胆管癌における肝外胆管切除症例の検討Poster presentation
- 第111回日本外科学会定期学術集会, May 2011, Japanese, 日本外科学会, 紙上開催, Domestic conference大腸癌肝転移に対する肝切除における術前化学療法の影響Poster presentation
- 第111回日本外科学会定期学術集会, May 2011, Japanese, 日本外科学会, 紙上開催, Domestic conference進行下部直腸癌に対する術前化学放射線に療法における側方リンパ節郭清の意義Oral presentation
- 第111回日本外科学会定期学術集会, May 2011, Japanese, 日本外科学会, 紙上開催, Domestic conference上部胃癌における脾臓合併切除の意義と、脾門部リンパ節の位置付けについての検討Poster presentation
- 第97回日本消化器病学会総会, May 2011, Japanese, 日本消化器病学会, 東京, Domestic conference初回肝切除後の再発肝癌に対する治療戦略Oral presentation
- 第97回日本消化器病学会総会, May 2011, Japanese, 日本消化器病学会, 東京, Domestic conference術中胆道造影時の膵管逆流現象についての検討Oral presentation
- 第97回日本消化器病学会総会, May 2011, Japanese, 日本消化器病学会, 東京, Domestic conference重複胆嚢の合併を疑った先天性胆道拡張症の1切除術Poster presentation
- 第111回日本外科学会定期学術集会, May 2011, Japanese, 日本外科学会, 紙上開催, Domestic conference巨大腫瘍を伴う両葉多発高度進行癌に対する新戦略:術前・術後経皮的肝灌流化学療法(PIHP)併用3段階療法Poster presentation
- 第97回日本消化器病学会総会, May 2011, Japanese, 日本消化器病学会, 東京, Domestic conference急性膵炎で発症し、主膵管と交通を認めた膵MCMの一例Poster presentation
- 第111回日本外科学会定期学術集会, May 2011, Japanese, 日本外科学会, 紙上開催, Domestic conference肝門部胆管癌に対する切除適応拡大に向けた新展開Oral presentation
- 第97回日本消化器病学会総会, May 2011, Japanese, 日本消化器病学会, 東京, Domestic conference肝内胆管癌と粘液産生胆管腫瘍(IPNB)症例におけるCD133発現についての検討Oral presentation
- 第111回日本外科学会定期学術集会, May 2011, Japanese, 日本外科学会, 紙上開催, Domestic conference肝切除における血管再建の是非Oral presentation
- 第111回日本外科学会定期学術集会, May 2011, Japanese, 日本外科学会, 紙上開催, Domestic conference胃切除後膵頭十二指腸切除術例の検討Poster presentation
- 第111回日本外科学会定期学術集会, May 2011, Japanese, 日本外科学会, 紙上開催, Domestic conference亜全胃温存膵頭十二指腸切除術(SSPPD)における再建術の工夫Oral presentation
- 第111回日本外科学会定期学術集会, May 2011, Japanese, 日本外科学会, 紙上開催, Domestic conferenceIPMNに対する縮小・低侵襲手術Poster presentation
- 第97回日本消化器病学会総会, May 2011, Japanese, 日本消化器病学会, 東京, Domestic conferenceGemcitabineによる進行胆道癌術後補助化学療法は有効かOral presentation
- 第97回日本消化器病学会総会, May 2011, Japanese, 日本消化器病学会, 東京, Domestic conferenceERPで主膵管途絶所見を呈し膵癌との鑑別が困難であった自己免疫性膵炎の1例Poster presentation
- 第111回日本外科学会定期学術集会, May 2011, Japanese, 日本外科学会, 紙上開催, Domestic conferenceBorderline resectable膵頭部癌の術前診断と切除意義の検討Oral presentation
- 第2回兵庫HCC分子標的治療セミナー, May 2011, Japanese, 日本消化器病学会, 神戸, Domestic conference-Others
- 第36回神戸放射線腫瘍懇話会, 2011, Japanese, 神戸放射線腫瘍懇話会, 神戸大学医学部附属病院(神戸市), Domestic conference吸収性スペーサーの新規開発における基礎的検討Oral presentation
- 第74回大腸癌研究会, Jan. 2011, Japanese, 大腸癌研究会, 福岡, Domestic conference術前化学放射線療法のリンパ節転移に対する制御能とその評価Oral presentation
- 第72回日本臨床外科学会総会, Nov. 2010, Japanese, 日本臨床外科学会, 横浜, Domestic conference膵漿液性嚢胞腫瘍(SCN)の画像診断に関する検討Oral presentation
- 第72回日本臨床外科学会総会, Nov. 2010, Japanese, 日本臨床外科学会, 横浜, Domestic conference膵頭十二指腸切除術後出血症例の検討Others
- 第72回日本臨床外科学会総会, Nov. 2010, Japanese, 日本臨床外科学会, 横浜, Domestic conference膵頭十二指腸切除における安全確実な膵空腸吻合手術手技Others
- 第188回近畿外科学会, Nov. 2010, Japanese, 近畿外科学会, 大阪, Domestic conference慢性膵炎に対するFrey手術の1例Oral presentation
- 第72回日本臨床外科学会総会, Nov. 2010, Japanese, 日本臨床外科学会, 横浜, Domestic conference虫垂粘液嚢胞腺癌の1切除例Oral presentation
- 第72回日本臨床外科学会総会, Nov. 2010, Japanese, 日本臨床外科学会, 横浜, Domestic conference早期胃癌に対するESD後の追加手術としての腹腔鏡下胃癌切除の検討Oral presentation
- 第72回日本臨床外科学会総会, Nov. 2010, Japanese, 日本臨床外科学会, 横浜, Domestic conference先天性胆道拡張症に対する総胆管嚢腫切除12年後に発生、切除した肝門部胆管癌の1例Oral presentation
- 第72回日本臨床外科学会総会, Nov. 2010, Japanese, 日本臨床外科学会, 横浜, Domestic conference石灰化を伴った膵粘液癌の2例Oral presentation
- 第188回近畿外科学会, Nov. 2010, Japanese, 近畿外科学会, 大阪, Domestic conference真性腸石の1手術例Oral presentation
- 第72回日本臨床外科学会総会, Nov. 2010, Japanese, 日本臨床外科学会, 横浜, Domestic conference自然退縮を来した肝細胞癌の3例Oral presentation
- 第72回日本臨床外科学会総会, Nov. 2010, Japanese, 日本臨床外科学会, 横浜, Domestic conference局所進行切除不能膵癌に対する粒子線治療Oral presentation
- 第72回日本臨床外科学会総会, Nov. 2010, Japanese, 日本臨床外科学会, 横浜, Domestic conferenceヒヤリ・ハット及びインシデント報告からみた外科治療における医療安全の現状と課題Oral presentation
- 第72回日本臨床外科学会総会, Nov. 2010, Japanese, 日本臨床外科学会, 横浜, Domestic conferenceMulti-detector-rowCT(MDCT)で診断したStage IV a膵癌の検討Oral presentation
- 第72回日本臨床外科学会総会, Nov. 2010, Japanese, 日本臨床外科学会, 横浜, Domestic conferenceBack flow perfusion法を用いた門脈腫瘍栓合併肝癌に対する肝切除Others
- JDDW(第8回日本消化器外科学会大会), Oct. 2010, Japanese, 日本消化器病学会, 横浜, Domestic conference膵内分泌腫瘍に対する外科治療の意義Poster presentation
- JDDW(第8回日本消化器外科学会大会), Oct. 2010, Japanese, 日本消化器病学会, 横浜, Domestic conference膵体尾部切除術におけるデュエットTRSTMの使用経験Poster presentation
- JDDW(第8回日本消化器外科学会大会), Oct. 2010, Japanese, 日本消化器病学会, 横浜, Domestic conference膵腫瘍核出術-主膵管近接例に対する工夫-Poster presentation
- JDDW(第52回日本消化器病学会大会), Oct. 2010, Japanese, 日本消化器病学会, 横浜, Domestic conference両葉多発肝細胞癌に対する治療戦略~神戸二段階療法~Poster presentation
- 第23回日本内視鏡外科学会総会, Oct. 2010, Japanese, 日本内視鏡外科学会, 横浜, Domestic conference腹腔鏡(補助)下膵体尾部分切除術の導入と術式の定型化Oral presentation
- JDDW(第8回日本消化器外科学会大会), Oct. 2010, Japanese, 日本消化器病学会, 横浜, Domestic conference腹腔鏡下膵体尾部分切除術-安全な手技と標準化へむけて-Poster presentation
- 第23回日本内視鏡外科学会総会, Oct. 2010, Japanese, 日本内視鏡外科学会, 横浜, Domestic conference当科における噴門部胃粘膜下腫瘍に対する腹腔鏡下胃部分切除術Oral presentation
- 第23回日本内視鏡外科学会総会, Oct. 2010, Japanese, 日本内視鏡外科学会, 横浜, Domestic conference当科における腹腔鏡下胃全摘術の食道空腸吻合法の変遷と標準化への工夫Oral presentation
- 第23回日本内視鏡外科学会総会, Oct. 2010, Japanese, 日本内視鏡外科学会, 横浜, Domestic conference大腸癌内視鏡治療穿孔症例に対する腹腔鏡下手術Oral presentation
- 第23回日本内視鏡外科学会総会, Oct. 2010, Japanese, 日本内視鏡外科学会, 横浜, Domestic conference大腸癌内視鏡治療後の追加治療における、腹腔鏡補助下手術の有用性Oral presentation
- 第23回日本内視鏡外科学会総会, Oct. 2010, Japanese, 日本内視鏡外科学会, 横浜, Domestic conference神経および血管温存に留意した食道癌に対する胸腔鏡下縦隔リンパ節郭清Others
- 第23回日本内視鏡外科学会総会, Oct. 2010, Japanese, 日本内視鏡外科学会, 横浜, Domestic conference食道癌に対する腹腔鏡補助下胃管再建術の治療成績Oral presentation
- JDDW(第8回日本消化器外科学会大会), Oct. 2010, Japanese, 日本消化器病学会, 横浜, Domestic conference重症急性膵炎後の中下部胆管癌手術症例の検討Poster presentation
- JDDW(第14回日本肝臓学会大会), Oct. 2010, Japanese, 日本肝臓学会, 横浜, Domestic conference骨転移を伴う肝細胞癌に対し、集学的治療を施行し長期生存を得た1例Poster presentation
- 第23回日本内視鏡外科学会総会, Oct. 2010, Japanese, 日本内視鏡外科学会, 横浜, Domestic conference鏡視下手術における新規臓器圧排用器具の臨床応用と問題点Others
- 第23回日本内視鏡外科学会総会, Oct. 2010, Japanese, 日本内視鏡外科学会, 横浜, Domestic conference胸腔鏡下食道切除術-症例に応じたアプローチ法の選択-Oral presentation
- JDDW(第8回日本消化器外科学会大会), Oct. 2010, Japanese, 日本消化器病学会, 横浜, Domestic conference巨大肝細胞癌に対する切除成績の検討Poster presentation
- JDDW(第8回日本消化器外科学会大会), Oct. 2010, Japanese, 日本消化器病学会, 横浜, Domestic conference肝内結石症に対する手術症例の検討Poster presentation
- 第23回日本内視鏡外科学会総会, Oct. 2010, Japanese, 日本内視鏡外科学会, 横浜, Domestic conference肝硬変症例に対する腹腔鏡下胆嚢摘出術の検討Oral presentation
- JDDW(第14回日本肝臓学会大会), Oct. 2010, Japanese, 日本肝臓学会, 横浜, Domestic conference外科治療成績からみた非B非C型肝癌の現状と問題点Poster presentation
- JDDW(第8回日本消化器外科学会大会), Oct. 2010, Japanese, 日本消化器病学会, 横浜, Domestic conference外科研修医教育を主眼に置いた腹腔鏡下胆嚢摘出術のトレーニングシステムPoster presentation
- 第23回日本内視鏡外科学会総会, Oct. 2010, Japanese, 日本内視鏡外科学会, 横浜, Domestic conference胃粘膜下腫瘍に対する単孔式腹腔鏡下手術Oral presentation
- JDDW(第8回日本消化器外科学会大会), Oct. 2010, Japanese, 日本消化器病学会, 横浜, Domestic conference悪性腫瘍との鑑別を要した自己免疫性膵炎の検討Poster presentation
- JDDW(第8回日本消化器外科学会大会), Oct. 2010, Japanese, 日本消化器病学会, 横浜, Domestic conferenceEn bloc郭清を目指した食道癌内視鏡外科手術の標準化とその工夫Poster presentation
- 第5回肝癌治療シミュレーション研究会, Sep. 2010, Japanese, 肝癌治療シミュレーション研究会, 東京, Domestic conferenceOsiriXとモバイル情報端末iPad/iPhoneによるStereo 3D立体視手術ナビゲーションと次世代低侵襲手術: NOTES, SPS, robotic surgeryOral presentation
- 第65回日本消化器外科学会総会, Jul. 2010, Japanese, 日本消化器外科学会総会, 下関, Domestic conference膵頭十二指腸切除術における膵貫通密着縫合とマイクロ用機器を用いた膵空腸吻合Oral presentation
- 第65回日本消化器外科学会総会, Jul. 2010, Japanese, 日本消化器外科学会総会, 下関, Domestic conference膵頭十二指腸切除術における周術期G-CSF投与の有効性に関する検討Poster presentation
- 第65回日本消化器外科学会総会, Jul. 2010, Japanese, 日本消化器外科学会総会, 下関, Domestic conference幽門輪温存膵頭十二指腸切除術(PPPD)と亜全胃温存膵頭十二指腸切除術(SSPPD)の比較検討[Invited]Invited oral presentation
- 第65回日本消化器外科学会総会, Jul. 2010, Japanese, 日本消化器外科学会総会, 下関, Domestic conference慢性肝疾患合併症に対する膵頭十二指腸切除術における周術期管理Oral presentation
- 第65回日本消化器外科学会総会, Jul. 2010, Japanese, 日本消化器外科学会総会, 下関, Domestic conference腹部悪性腫瘍に対する粒子線治療の適応拡大を目指した吸収性新規Spacerの開発Poster presentation
- 第65回日本消化器外科学会総会, Jul. 2010, Japanese, 日本消化器外科学会総会, 下関, Domestic conference当科における腹腔鏡補助下幽門側胃切除後B-I法再建時の工夫Others
- 第65回日本消化器外科学会総会, Jul. 2010, Japanese, 日本消化器外科学会総会, 下関, Domestic conference当科における腹腔鏡補助下胃管再建術-さらなるMinimal invasive esophagectomyへ-Public symposium
- 第65回日本消化器外科学会総会, Jul. 2010, Japanese, 日本消化器外科学会総会, 下関, Domestic conference当科での肝硬変症例に対する腹腔鏡下胆嚢摘出術Poster presentation
- 第65回日本消化器外科学会総会, Jul. 2010, Japanese, 日本消化器外科学会総会, 下関, Domestic conference当院における食道癌術後再発症例に対してのSalvageCRT(FP-RT)療法の治療成績Poster presentation
- 第65回日本消化器外科学会総会, Jul. 2010, Japanese, 日本消化器外科学会総会, 下関, Domestic conference転移性肝癌に対する術前化学療法の手術における安全性Oral presentation
- 第65回日本消化器外科学会総会, Jul. 2010, Japanese, 日本消化器外科学会総会, 下関, Domestic conference摘出肝由来血管による肝静脈パッチワーク再建Others
- 第65回日本消化器外科学会総会, Jul. 2010, Japanese, 日本消化器外科学会総会, 下関, Domestic conference低酸素環境下における癌細胞の悪性度獲得機構の解明[Invited]Invited oral presentation
- 第65回日本消化器外科学会総会, Jul. 2010, Japanese, 日本消化器外科学会総会, 下関, Domestic conference胆道造影下3D-CTを利用した肝門部胆管癌に対する治療戦略Poster presentation
- 第65回日本消化器外科学会総会, Jul. 2010, Japanese, 日本消化器外科学会総会, 下関, Domestic conference進行度からみた十二指腸乳頭部癌切除症例の検討Public symposium
- 第65回日本消化器外科学会総会, Jul. 2010, Japanese, 日本消化器外科学会総会, 下関, Domestic conference径30cmの非B非C巨大肝細胞癌の1切除例Poster presentation
- 第65回日本消化器外科学会総会, Jul. 2010, Japanese, 日本消化器外科学会総会, 下関, Domestic conference巨大肝細胞癌に対する安全な肝臓切除術Poster presentation
- 第65回日本消化器外科学会総会, Jul. 2010, Japanese, 日本消化器外科学会総会, 下関, Domestic conference胃粘膜下腫瘍に対する単孔式腹腔鏡下胃部分切除術の適応と手技の工夫Oral presentation
- 第65回日本消化器外科学会総会, Jul. 2010, Japanese, 日本消化器外科学会総会, 下関, Domestic conferenceインスリノーマに対する膵腫瘍核出術の手術手技Others
- 第65回日本消化器外科学会総会, Jul. 2010, Japanese, 日本消化器外科学会総会, 下関, Domestic conferenceVp4を伴う高度進行肝細胞癌に対する治療戦略~神戸二段階療法~[Invited]Invited oral presentation
- 第65回日本消化器外科学会総会, Jul. 2010, Japanese, 日本消化器外科学会総会, 下関, Domestic conferencess胆嚢癌切除症例の検討Oral presentation
- 第65回日本消化器外科学会総会, Jul. 2010, Japanese, 日本消化器外科学会総会, 下関, Domestic conferencePortal annular pancreas合併十二指腸乳頭部癌に対し膵頭十二指腸切除を施行した一例Poster presentation
- 第65回日本消化器外科学会総会, Jul. 2010, Japanese, 日本消化器外科学会総会, 下関, Domestic conferenceGemcitabineによる胆道癌術後補助化学療法の効果予測Poster presentation
- 第65回日本消化器外科学会総会, Jul. 2010, Japanese, 日本消化器外科学会総会, 下関, Domestic conference10cm以上の肝細胞癌における減量肝切除の意義Poster presentation
- 日本消化器病学会近畿支部第92回例会, Feb. 2010, Japanese, 日本消化器病学会, 大阪, Domestic conference減量肝切除+経皮的肝灌流による外科集学的治療戦略Oral presentation
- 日本消化器病学会近畿支部第92回例会, Feb. 2010, Japanese, 日本消化器病学会, 大阪, Domestic conference原因不明の良性胆管狭窄に対し胆管切除・胆道再建術を施行した1例Oral presentation
- 日本消化器病学会近畿支部第92回例会, Feb. 2010, Japanese, 日本消化器病学会, 大阪, Domestic conference9年間にわたり急性膵炎を繰り返した膵尾部IPMNの1例Oral presentation
- 第22回日本内視鏡外科学会総会, Dec. 2009, Japanese, 日本内視鏡外科学会, 東京, Domestic conference膵体尾部腫瘍に対するHALS (hand-assisted laparoscopic surgery)の有用性Oral presentation
- 第22回日本内視鏡外科学会総会, Dec. 2009, Japanese, 日本内視鏡外科学会, 東京, Domestic conference腹腔鏡下胆嚢摘出術における術中胆道造影の成績に関する検討Oral presentation
- 第22回日本内視鏡外科学会総会, Dec. 2009, Japanese, 日本内視鏡外科学会, 東京, Domestic conferenceIPMNに対する腹腔鏡補助下膵体尾部切除術Oral presentation
- 第71回日本臨床外科学会, Nov. 2009, Japanese, 日本臨床外科学会, 京都, Domestic conference膵頭十二指腸切除術における膵貫通密着縫合と確実な吻合による膵空腸吻合手術手技Oral presentation
- 第71回日本臨床外科学会, Nov. 2009, Japanese, 日本臨床外科学会, 京都, Domestic conference膵頭十二指腸切除術における膵液瘻の評価とISGPF分類の問題点Oral presentation
- 第71回日本臨床外科学会, Nov. 2009, Japanese, 日本臨床外科学会, 京都, Domestic conference膵中央切除の手術手技と成績Oral presentation
- 第71回日本臨床外科学会, Nov. 2009, Japanese, 日本臨床外科学会, 京都, Domestic conference門脈腫瘍栓を合併した肝細胞癌に対する術前肝機能評価の検討Oral presentation
- 第71回日本臨床外科学会, Nov. 2009, Japanese, 日本臨床外科学会, 京都, Domestic conference腹腔鏡補助下膵体尾部切除術の手技と成績Oral presentation
- 第71回日本臨床外科学会, Nov. 2009, Japanese, 日本臨床外科学会, 京都, Domestic conference造影下3D-CT胆管バーチャル画像の手術への応用と限界Oral presentation
- 第71回日本臨床外科学会, Nov. 2009, Japanese, 日本臨床外科学会, 京都, Domestic conference肝門部胆管癌の現在の治療戦略Oral presentation
- 第71回日本臨床外科学会, Nov. 2009, Japanese, 日本臨床外科学会, 京都, Domestic conference肝-8Public symposium
- 第71回日本臨床外科学会, Nov. 2009, Japanese, 日本臨床外科学会, 京都, Domestic conference胃癌と十二指腸乳頭部小細胞癌の重複例に対し膵頭十二指腸切除術を施行した一症例Oral presentation
- 第71回日本臨床外科学会, Nov. 2009, Japanese, 日本臨床外科学会, 京都, Domestic conferenceG-CSF 産生肝細胞癌のリンパ節転移再発に対する切除例Oral presentation
- 第45回日本胆道学会学術集会, Sep. 2009, Japanese, 日本胆道学会, 東京, Domestic conference当科での胆道癌術前評価におけるFDG-PETの検討Oral presentation
- 第45回日本胆道学会学術集会, Sep. 2009, Japanese, 日本胆道学会, 東京, Domestic conference胆道癌に対するGemcitabine, S-1段階的治療の成績と課題Oral presentation
- 第45回日本胆道学会学術集会, Sep. 2009, Japanese, 日本胆道学会, 東京, Domestic conference大動脈周囲を含む広範リンパ節転移を認めた30mm大の十二指腸乳頭部癌の1手術例Poster presentation
- 第91回日本消化器病学会 近畿支部, Sep. 2009, Japanese, 日本消化器病学会, 京都, Domestic conference術前診断に苦慮した膵漿液性嚢胞腫瘍に対して縮小手術を行った2例Oral presentation
- 第36回日本膵切研究会, Aug. 2009, Japanese, 日本膵切研究会, 和歌山, Domestic conference膵頭十二指腸切除術におけるISGPF基準による膵液瘻の評価Poster presentation
- 第64回日本消化器外科学会総会, Jul. 2009, Japanese, 日本消化器外科学会, 大阪, Domestic conference膵中央切除の手術手技と成績Poster presentation
- 第64回日本消化器外科学会総会, Jul. 2009, Japanese, 日本消化器外科学会, 大阪, Domestic conference膵体尾部腫瘍に対するHand-assisted distal pancreatectomyPoster presentation
- 第64回日本消化器外科学会総会, Jul. 2009, Japanese, 日本消化器外科学会, 大阪, Domestic conference門脈腫瘍栓合併肝細胞癌における術前肝機能評価の検討Poster presentation
- 第27回日本肝移植研究会, Jul. 2009, Japanese, 日本肝移植研究会, 静岡, Domestic conference門脈血栓合併生体肝移植における門脈再建の工夫Oral presentation
- 第64回日本消化器外科学会総会, Jul. 2009, Japanese, 日本消化器外科学会, 大阪, Domestic conference走査型蛍光X線顕微鏡による肝組織内鉄分布の解析Poster presentation
- 第45回日本肝癌研究会, Jul. 2009, Japanese, 日本肝癌研究会, 福岡, Domestic conference再発後外科的切除例からみた肝細胞癌に対するラジオ波焼灼療法の適応と限界Oral presentation
- 第64回日本消化器外科学会総会, Jul. 2009, Japanese, 日本消化器外科学会, 大阪, Domestic conference根治切除不能肝門部胆管癌に対する外科集学的先端戦略の展開Oral presentation
- 第64回日本消化器外科学会総会, Jul. 2009, Japanese, 日本消化器外科学会, 大阪, Domestic conference高度脈管侵襲陽性肝細胞癌に対する粒子線治療成績の検討Public symposium
- 第64回日本消化器外科学会総会, Jul. 2009, Japanese, 日本消化器外科学会, 大阪, Domestic conference肝 症例Public symposium
- 第45回日本肝癌研究会, Jul. 2009, Japanese, 日本肝癌研究会, 福岡, Domestic conference肝細胞癌切除術後の門脈腫瘍栓を伴った肝細胞癌に対する肝再切除例Oral presentation
- 第45回日本肝癌研究会, Jul. 2009, Japanese, 日本肝癌研究会, 福岡, Domestic conferenceVp4肝細胞癌における門脈腫瘍栓摘出術Oral presentation
- 第64回日本消化器外科学会総会, Jul. 2009, Japanese, 日本消化器外科学会, 大阪, Domestic conferenceVp3,4を伴う超高度進行肝細胞癌に対する治療戦略〜神戸二段階療法〜Public symposium
- 第64回日本消化器外科学会総会, Jul. 2009, Japanese, 日本消化器外科学会, 大阪, Domestic conferenceMatch Pair解析を用いた成人生体部分肝移植と脳死全肝移植の比較検討Public symposium
- 第27回日本肝移植研究会, Jul. 2009, Japanese, 日本肝移植研究会, 静岡, Domestic conferenceMatch Pair解析による生体部分肝移植と脳死全肝移植の治療成績の比較検討Oral presentation
- 第21回日本肝胆膵外科学会学術集会, Jun. 2009, Japanese, 日本肝胆膵外科学会, 名古屋, Domestic conference膵頭十二指腸切除術におけるマイクロ用機器を用いた安全、確実な膵・空腸吻合術Oral presentation
- 第21回日本肝胆膵外科学会学術集会, Jun. 2009, Japanese, 日本肝胆膵外科学会, 名古屋, Domestic conference膵体尾部腫瘍に対する鏡視下手術の適応と術式Oral presentation
- 第21回日本肝胆膵外科学会学術集会, Jun. 2009, Japanese, 日本肝胆膵外科学会, 名古屋, Domestic conference嚢胞性部分を認め診断及び術式を含めた治療方針に苦慮したStage I 浸潤性膵管癌の1例Oral presentation
- 第21回日本肝胆膵外科学会学術集会, Jun. 2009, Japanese, 日本肝胆膵外科学会, 名古屋, Domestic conference当科における膵中央切除の手術手技と短期成績Oral presentation
- 第185回近畿外科学会, Jun. 2009, Japanese, 近畿外科学会, 神戸, Domestic conference術前ENPDチューブ留置により安全に核手術を施行し得たインスリノーマの1例Oral presentation
- 第21回日本肝胆膵外科学会学術集会, Jun. 2009, Japanese, 日本肝胆膵外科学会, 名古屋, Domestic conference術後4年目の再発巣に対して切除を行った粘液産生胆管癌の1例Poster presentation
- 第21回日本肝胆膵外科学会学術集会, Jun. 2009, Japanese, 日本肝胆膵外科学会, 名古屋, Domestic conference経皮的肝灌流化学療法(PIHP)誕生のきっかけOral presentation
- 第21回日本肝胆膵外科学会学術集会, Jun. 2009, Japanese, 日本肝胆膵外科学会, 名古屋, Domestic conference肝門部胆管癌の切除成績と補助療法の有用性Poster presentation
- 第185回近畿外科学会, Jun. 2009, Japanese, 近畿外科学会, 神戸, Domestic conference横隔膜筋層内に転移した肝細胞癌の1例Oral presentation
- 第21回日本肝胆膵外科学会学術集会, Jun. 2009, Japanese, 日本肝胆膵外科学会, 名古屋, Domestic conferenceVp4を伴う超高度進行肝細胞癌における術式合理化の工夫Oral presentation
- 第21回日本肝胆膵外科学会学術集会, Jun. 2009, Japanese, 日本肝胆膵外科学会, 名古屋, Domestic conference99mTc-GSA シンチグラフィーによる門脈閉塞、非閉塞葉の分肝機能解析ー慣用切除の安全性評価Oral presentation
- 第95回日本消化器病学会総会, May 2009, Japanese, 日本消化器病学会, 札幌, Domestic conference術前肝門部胆管癌との鑑別が困難であったIgG4関連硬化性胆管炎の1例Poster presentation
- 第95回日本消化器病学会総会, May 2009, Japanese, 日本消化器病学会, 札幌, Domestic conferenceラジオ波焼灼療法後、再発肝細胞癌に対する治療と外科的切除例の検討Oral presentation
- 第109回日本外科学会定期学術集会, Apr. 2009, Japanese, 日本外科学会, 福岡, Domestic conference粒子線治療と外科治療との融合:スペーサー手術による粒子線治療の適応拡大Oral presentation
- 第109回日本外科学会定期学術集会, Apr. 2009, Japanese, 日本外科学会, 福岡, Domestic conference放射光による超高感度2次元マッピングを用いた肝組織内鉄分布と鉄代謝の関係Oral presentation
- 第109回日本外科学会定期学術集会, Apr. 2009, Japanese, 日本外科学会, 福岡, Domestic conference超高度進行肝癌に対する新しい治療戦略:術前・術後経皮的肝灌流(PIHP)併用三段階療法Poster presentation
- 第109回日本外科学会定期学術集会, Apr. 2009, Japanese, 日本外科学会, 福岡, Domestic conference大血管侵襲を伴う超進行肝癌に対する術式選択〜合併症ゼロを目指して〜Oral presentation
- 第109回日本外科学会定期学術集会, Apr. 2009, Japanese, 日本外科学会, 福岡, Domestic conference切除不能胆嚢癌に対する集学的切除新戦略Poster presentation
- 第109回日本外科学会定期学術集会, Apr. 2009, Japanese, 日本外科学会, 福岡, Domestic conference肝門部胆管癌に対するENBDを用いた胆管造影下3D-CTによる切離線決定Poster presentation
- 第109回日本外科学会定期学術集会, Apr. 2009, Japanese, 日本外科学会, 福岡, Domestic conferenceリンパ節転移陽性肝細胞癌に対する外科的切除の意義Poster presentation
- 第109回日本外科学会定期学術集会, Apr. 2009, English, 日本外科学会, 福岡, Domestic conferenceHand-assisted laparoscopic distal pancreatectomy:its safety and efficacy in laparoscopic pancreatic surgeryOral presentation
- 第90回例会日本消化器外科学会近畿支部, Feb. 2009, Japanese, 日本消化器外科学会近畿支部, 大阪, Domestic conference膵管内進展、門脈内腫瘍栓を呈した膵悪性非機能性内分泌腫瘍の1例Others
- 第90回例会日本消化器外科学会近畿支部, Feb. 2009, Japanese, 日本消化器外科学会近畿支部, 大阪, Domestic conference低容量インターフェロン・リバビリン長期併用療法におけるC型肝炎肝移植後の肝炎制御Others
- 第90回例会日本消化器外科学会近畿支部, Feb. 2009, Japanese, 日本消化器外科学会近畿支部, 大阪, Domestic conference原発巣の同定および治療方針の決定に苦慮したS状結腸癌と膵癌の重複肝転移の一例Others
- 第184回 近畿外科学会, Dec. 2008, Japanese, 近畿外科学会, 奈良, Domestic conference妊娠20週妊婦に対する腹腔鏡下胆嚢摘出術の経験Others
- 第184回 近畿外科学会, Dec. 2008, Japanese, 近畿外科学会, 奈良, Domestic conference画像上肝細胞癌と鑑別が困難であった限局性結節性過形成の一例Others
- 第184回 近畿外科学会, Dec. 2008, Japanese, 近畿外科学会, 奈良, Domestic conferenceVon-Hipper-Lindau病に合併した膵内分泌腫瘍、褐色細胞腫リンパ節再発の切除例Others
- The 6th International Meeting, Hepatocellular Carcinoma: Eastern and Western Experiences (IMHCC2008), Dec. 2008, English, International Meeting, Hepatocellular Carcinoma: Eastern and Western Experiences, ソウル, 韓国, International conferenceParticle Radiotherapy For Patients With Hepatocellular CarcinomaOthers
- The 6th International Meeting, Hepatocellular Carcinoma: Eastern and Western Experiences (IMHCC2008), Dec. 2008, English, International Meeting, Hepatocellular Carcinoma: Eastern and Western Experiences, ソウル, 韓国, International conferenceIron metabolism and its tissue distribution in liver cirrhosis determined by two-dimensional mapping with a novel synchrotron radiation X-ray fluorescence spectroscopy; the possible role in hepatocarcinogenesisOthers
- 第184回 近畿外科学会, Dec. 2008, Japanese, 近畿外科学会, 奈良, Domestic conferenceHALSによる脾動静脈温存脾温存尾側膵切除術を施行し1例Others
- 第70回 日本臨床外科学会総会, Nov. 2008, Japanese, 日本臨床外科学会, 東京, Domestic conference膵癌切除率向上を目指した膵頭十二指腸切除術における肝動脈・門脈同時合併切除再建術の要点Oral presentation
- 第70回 日本臨床外科学会総会, Nov. 2008, Japanese, 日本臨床外科学会, 東京, Domestic conference成人生体肝移植後、胆管狭窄に対して再吻合術を施行した2例Oral presentation
- 第70回 日本臨床外科学会総会, Nov. 2008, Japanese, 日本臨床外科学会, 東京, Domestic conference腎細胞癌転移6例の検討Oral presentation
- 第70回 日本臨床外科学会総会, Nov. 2008, Japanese, 日本臨床外科学会, 東京, Domestic conference術前診断肝内胆管癌が強く疑われた肝炎症性偽腫瘍の一例Oral presentation
- 第70回 日本臨床外科学会総会, Nov. 2008, Japanese, 日本臨床外科学会, 東京, Domestic conference術前にMRCPにて診断し、安全に手術し得た重複胆管を伴う急性胆嚢炎の1例Oral presentation
- 第70回 日本臨床外科学会総会, Nov. 2008, Japanese, 日本臨床外科学会, 東京, Domestic conference肝切除における新しいサイドリトラクターによる視野展開Oral presentation
- 第70回 日本臨床外科学会総会, Nov. 2008, Japanese, 日本臨床外科学会, 東京, Domestic conference肝-2Oral presentation
- JDDW 2008 第50回消化器病学会大会, Oct. 2008, Japanese, 消化器病学会, 東京, Domestic conference門脈腫瘍栓の進展速度からみた門脈腫瘍栓合併肝癌の治療方針Poster presentation
- JDDW 2008 第12回日本肝臓学会大会, Oct. 2008, Japanese, 日本肝臓学会, 東京, Domestic conference進行肝癌に対する外科的新治療戦略:減量肝切除と2段階治療の意義Oral presentation
- JDDW 2008 第50回日本消化器病学会大会, Oct. 2008, Japanese, 日本消化器病学会, 東京, Domestic conference肝内、肝門部胆管癌に対するGEM, S-1療法の成績Poster presentation
- 第12回 日本肝臓学会大会, Oct. 2008, Japanese, 日本消化器内視鏡学会, 東京, Domestic conference肝移植後C型肝炎に対する少量長期ペグインターフェロン/リバビリン併用療法の検討Poster presentation
- 第46回日本癌治療学会総会, Oct. 2008, Japanese, 日本癌治療学会, 名古屋, Domestic conferenceスペーサー手術による粒子線治療の適応拡大:腹部腫瘍はどこまで治療可能か?Oral presentation
- The 7th Korea〜Japan Transplantation Forum, Oct. 2008, English, Transplantation Forum, ソウル, 韓国, International conferenceThe treatment of hepatocellular carcinoma within the Milan criteria: Hepatectomy versus liver transplantationPoster presentation
- The 7th Korea〜Japan Transplantation Forum, Oct. 2008, English, Transplantation Forum, ソウル, 韓国, International conferenceShould we return to the left in adult living donor liver transplantation?Others
- 第44回 日本胆道学会, Sep. 2008, Japanese, 日本胆道学会, 名古屋, Domestic conference免疫能からみた肝門部胆管癌術前減黄における内瘻術の有用性とENBDを用いた胆管造影下3D-CTによる切離線決定Oral presentation
- 第89回例会 日本消化器病学会近畿支部, Sep. 2008, Japanese, 日本消化器病学会, 大阪, Domestic conference選択的カルシウム動中試験(ASVS)にて局在診断し腹腔鏡下腫瘍核手術を施行したインスリノーマの1例Oral presentation
- 第44回 日本移植学会総会, Sep. 2008, Japanese, 日本移植学会, 大阪, Domestic conference生体肝移植前に免疫制御剤の投与を必要とした急性赤芽癆合合併原発性硬化性胆管炎の1例Poster presentation
- 第44回 日本移植学会総会, Sep. 2008, Japanese, 日本移植学会, 大阪, Domestic conference成人生体移植における周術期の感染症対策Poster presentation
- 第89回例会 日本消化器病学会近畿支部, Sep. 2008, Japanese, 日本消化器病学会, 大阪, Domestic conference腎細胞癌膵転移の1例切除例Oral presentation
- 第63回日本消化器外科学会, Jul. 2008, Japanese, 日本消化器外科学会, 札幌, Domestic conference非B型非C型肝細胞癌の治療成績からみた外科治療上の問題Oral presentation
- 第63回日本消化器外科学会, Jul. 2008, Japanese, 日本消化器外科学会, 札幌, Domestic conference大血管浸襲を伴う進行肝癌に対する術式合理化の工夫Oral presentation
- 第63回日本消化器外科学会, Jul. 2008, Japanese, 日本消化器外科学会, 札幌, Domestic conference成人生体部分肝移植における移植後のグラフト回転を考慮した新しい肝静脈再建法Oral presentation
- 第63回日本消化器外科学会, Jul. 2008, Japanese, 日本消化器外科学会, 札幌, Domestic conference自験例からみた十二指腸乳頭部癌縮小手術の至適条件Others
- 第63回日本消化器外科学会, Jul. 2008, Japanese, 日本消化器外科学会, 札幌, Domestic conference再発胆道癌に対する化学療法を中心とした治療成績Oral presentation
- 第63回日本消化器外科学会, Jul. 2008, Japanese, 日本消化器外科学会, 札幌, Domestic conference肝細胞癌に対する粒子線治療成績の検討Oral presentation
- THE INTERNATIONAL LIVER TRANSPLANTATION SOCIETY 14TH ANNUAL INTERNATIONAL CONGRESS, Jul. 2008, English, THE INTERNATIONAL LIVER TRANSPLANTATION SOCIETY, パリ, フランス, International conferenceSHOULD WE RETURN TO THE LEFT IN ADULT LIVING DONOR LIVER TRANSPLANTATION?Others
- 第44回日本肝臓学会, Jun. 2008, Japanese, 日本肝臓学会, 愛媛, Domestic conference肝組織内微量金属元素の画像解析を用いた C 型肝細胞癌発癌メカニズムの検討Others
- 第44回日本肝臓学会, Jun. 2008, Japanese, 日本肝臓学会, 愛媛, Domestic conference肝細胞癌切除後の長期生存例に関する検討Poster presentation
- 第94回日本消化器病学会, May 2008, Japanese, 日本消化器病学会, 福岡, Domestic conference非B非C型肝細胞癌の外科治療成績からみた治療上の課題Oral presentation
- 第108回日本外科学会, May 2008, Japanese, 日本外科学会, 長崎, Domestic conference非B非C型肝細胞癌の治療成績からみた外科治療上の課題Poster presentation
- 第20回日本肝胆膵外科学会・学術集会, May 2008, Japanese, 日本肝胆膵外科学会, 山形, Domestic conference進行度からみた十二指腸乳頭部癌切除症例の検討Poster presentation
- 第108回日本外科学会, May 2008, Japanese, 日本外科学会, 長崎, Domestic conference術中胆道造影で検出された膵管内逆流現象についての検討Poster presentation
- 第108回日本外科学会, May 2008, Japanese, 日本外科学会, 長崎, Domestic conference血管新生、リンパ管新生、VEGF発現などの分子標的マーカーは胆嚢癌の転移進展過程を反映するか?Poster presentation
- 第94回日本消化器病学会, May 2008, Japanese, 日本消化器病学会, 福岡, Domestic conference肝組織内微量金属元素の定量と画像解析を用いたC型肝細胞癌発癌メカニズムの検討Oral presentation
- 第108回日本外科学会, May 2008, Japanese, 日本外科学会, 長崎, Domestic conference肝組織内微量金属元素の画像解析からみたC型肝細胞癌発癌メカニズムの検討Poster presentation
- 第20回日本肝胆膵外科学会・学術集会, May 2008, Japanese, 日本肝胆膵外科学会, 山形, Domestic conference肝細胞癌切除後の長期生存例の検討Others
- 第108回日本外科学会, May 2008, Japanese, 日本外科学会, 長崎, Domestic conference肝細胞癌手術困難例に対する粒子線治療の意義Oral presentation
- 第20回日本肝胆膵外科学会・学術集会, May 2008, Japanese, 日本肝胆膵外科学会, 山形, Domestic conference肝癌における先進的術式:従来切除不能多発進行肝癌に対する減量切除+経皮的肝灌流(2段階治療)の有用性Others
- 第108回日本外科学会, May 2008, Japanese, 日本外科学会, 長崎, Domestic conference下大静脈直接浸潤肝癌に対するLiver Hanging Maneuver を用いた肝右葉切除術Oral presentation
- 第108回日本外科学会, May 2008, Japanese, 日本外科学会, 長崎, Domestic conferenceVp4肝細胞癌肝切除における偶発症回避への工夫: Back Flow Perfusion(BFP)法による門脈腫瘍栓摘出術Oral presentation
- 第20回日本肝胆膵外科学会・学術集会, May 2008, Japanese, 日本肝胆膵外科学会, 山形, Domestic conferenceVp-4を超える高度進行肝細胞癌に対する新しい術式Others
- 第20回日本肝胆膵外科学会・学術集会, May 2008, Japanese, 日本肝胆膵外科学会, 山形, Domestic conference4年間経過観察後に切除された胆管内発育型肝内胆管癌の1例Poster presentation
- 第37回日本肝臓学会西部会, Dec. 2007, Japanese, 日本肝臓学会西部会, 長崎, Domestic conferenceC型肝炎ウィルスの肝発癌過程における肝組織内微量金属元素の分布と定量分析Others
- 第69回日本臨床外科学会, Nov. 2007, Japanese, 日本臨床外科学会, 横浜, Domestic conference慢性B型肝炎に合併した巨大な肝内胆管癌の1例Others
- 第69回日本臨床外科学会, Nov. 2007, Japanese, 日本臨床外科学会, 横浜, Domestic conference胆嚢癌が鑑別困難であった胆摘例における指針Others
- 第43回日本移植学会総会, Nov. 2007, Japanese, 日本移植学会, 仙台, Domestic conference全肝移植後両葉多発再来を来たし経皮的肝灌流にてCRとなった肝細胞癌の1例Oral presentation
- 第69回日本臨床外科学会総会, Nov. 2007, Japanese, 日本臨床外科学会, 横浜, Domestic conference巨大な肝動脈瘤を随伴したFNHの一例Oral presentation
- 第69回日本臨床外科学会総会, Nov. 2007, Japanese, 日本臨床外科学会, 横浜, Domestic conference肝細胞癌に対する粒子線治療成績の検討Oral presentation
- 第69回日本臨床外科学会, Nov. 2007, Japanese, 日本臨床外科学会, 横浜, Domestic conferenceVp3,4両葉多発肝細胞癌における切除の役割:減量肝切除+経皮的肝灌流の2段階外科療法の有効性Others
- 第47回日本消化器画像診断研究会, Sep. 2007, Japanese, 日本消化器画像診断研究会, 福岡, Domestic conference多発肝転移で発見された十二指腸カルチノイドの1例Oral presentation
- The5thJUCTS(Japan-USCancerTherapySymposium), Sep. 2007, English, JUCTS (Japan-US Cancer Therapy Symposium), 仙台, International conferenceParticle Therapy Against HCC Clinical Results of 103 casesOral presentation
- 第25回日本肝移植研究会, Jul. 2007, Japanese, 日本肝移植研究会, 東京, Domestic conference胆管狭窄に対する生体肝移植を担保した術式選択Oral presentation
- 第62回日本消化器外科学会, Jul. 2007, Japanese, 日本消化器外科学会, 東京, Domestic conference全肝移植後両葉多発再発を来たし経皮的肝灌流療法にてCRとなった肝細胞癌の1例Others
- 第62回日本消化器外科学会, Jul. 2007, Japanese, 日本消化器外科学会, 東京, Domestic conference術中判断により術式を胆道再建から生体肝移植術に変更した胆道狭窄症の1例Others
- 第62回日本消化器外科学会, Jul. 2007, Japanese, 日本消化器外科学会, 東京, Domestic conference肝細胞癌に対する肝移植の現況と課題_肝機能良好例に対する適応基準についてOral presentation
- 第62回日本消化器外科学会, Jul. 2007, Japanese, 日本消化器外科学会, 東京, Domestic conferenceVp3,4を伴う進行多発肝細胞癌に対する術式の工夫Others
- 第62回日本消化器外科学会, Jul. 2007, Japanese, 日本消化器外科学会, 東京, Domestic conferencestage III,IV進行肝細胞癌に対する外科治療—経皮的肝灌流併用の意義Oral presentation
- 第25回日本肝移植研究会, Jul. 2007, Japanese, 日本肝移植研究会, 東京, Domestic conferenceC型肝炎肝移植後の課題とその対策Oral presentation
- 第62回日本消化器外科学会, Jul. 2007, Japanese, 日本消化器外科学会, 東京, Domestic conferenceC型肝炎ウイルスの肝発癌過程における肝組織内微量金属元素の分布と定量分析Oral presentation
- 第38回日本膵臓学会, Jun. 2007, Japanese, 日本膵臓学会, 福岡, Domestic conference等科における悪性膵内分泌腫瘍の治療成績Others
- 第38回日本膵臓学会大会, Jun. 2007, Japanese, 日本膵臓学会, 福岡, Domestic conference当科における悪性膵内分泌腫瘍の治療成績Others
- 第43回日本肝癌研究会, Jun. 2007, Japanese, 日本肝癌研究会, 東京, Domestic conference全肝移植後肝内多発再来を来たし、経皮的肝灌流化学療法にて完全寛解を得た肝細胞癌の一例Poster presentation
- 第43回日本肝癌研究会, Jun. 2007, Japanese, 日本肝癌研究会, 東京, Domestic conference肝細胞癌と肝内胆管癌の同時性重複癌の1手術症例Poster presentation
- 第43回日本肝癌研究会, Jun. 2007, Japanese, 日本肝癌研究会, 東京, Domestic conferenceVp3,4 進行肝細胞癌に対する肝動注化学療法の治療選択Public symposium
- 第43回日本肝臓学会総会, May 2007, Japanese, 日本肝臓学会, 東京, Domestic conference進行肝細胞癌における門脈腫瘍栓の発育進展速度の解析Oral presentation
- 第43回日本肝臓学会総会, May 2007, Japanese, 日本肝臓学会, 東京, Domestic conference高度進行肝癌に対する治療の工夫:従来切除不能多発例を対象とした減量肝切除+経皮的肝灌流による外科集学的治療の有用性Others
- 第43回日本肝臓学会総会, May 2007, Japanese, 日本肝臓学会, 東京, Domestic conference肝細胞癌に対する重粒子線治療成績の検討Others
- 第43回日本肝臓学会総会, May 2007, Japanese, 日本肝臓学会, 東京, Domestic conferenceC型肝炎ウィルスの肝発癌過程における肝組織内微量金属元素の役割Others
- Digestivediseaseweek2007,Washington, May 2007, English, DDW, ワシントン, アメリカ, International conferenceAntitumor Effect of TS-1 On Inoculated Human Biliary Cancer Cells in Nude Mice.Poster presentation
- 第107回日本外科学会, Apr. 2007, Japanese, 日本外科学会, 大阪, Domestic conference成人生体肝移植ドナーにおける残存肝の肝機能と容積変化の解析Others
- 第107回日本外科学会, Apr. 2007, Japanese, 日本外科学会, 大阪, Domestic conference高度血管侵襲(Vp3.4)を伴う両葉多発進行肝癌に対する先端治療戦略:減量肝切除+経皮的肝灌流の2段階治療Others
- 第107回日本外科学会, Apr. 2007, Japanese, 日本外科学会, 大阪, Domestic conference肝細胞癌に対する重粒子線治療の治療成績の検討Others
- 第107回日本外科学会, Apr. 2007, Japanese, 日本外科学会, 大阪, Domestic conference肝細胞癌に対するラジオ波焼灼療法と肝切除による再発形式の比較検討Others
- 第107回日本外科学会, Apr. 2007, Japanese, 日本外科学会, 青森, Domestic conference肝移植成績の日仏比較からみた脳死肝移植必要性Others
- The3rdScientificMeetingoftheInternationalForumofLiverSurgery, Apr. 2007, English, Scientific Meeting of the International Forum of Liver Surgery, 神戸, International conferenceWhere is the Limit of Surgery for Bilobar Metastatic Liver Tumors-Report of Representative Cases.Others
- The3rdScientificMeetingoftheInternationalForumofLiverSurgery, Apr. 2007, English, Scientific Meeting of the International Forum of Liver Surgery, 神戸, International conferenceParticle therapy for HCC: Clinical Results of 103 cases.Others
- The3rdScientificMeetingoftheInternationalForumofLiverSurgery, Apr. 2007, English, Scientific Meeting of the International Forum of Liver Surgery, 神戸, International conferenceComplete Response of Recurrence HCC Induced by Percutaneous Isolated Hepatic Perfusion (PIHP) in Patient with Liver Transplantation.Others
- APASL 2007 Kyoto, Mar. 2007, English, The Japan Society of Hepatology (日本肝臓学会), Kyoto, International conferenceSevere Recurrenthepatitis after Living Donor Liver Transplantation for Unknown Cause.Poster presentation
- APASL 2007 Kyoto, Mar. 2007, English, The Japan Society of Hepatology (日本肝臓学会), Kyoto, International conferenceReductive Hepatectomy and isolated Liver Perfusion for Vp3&4 Disseminated Hepatocellular Carcinoma.Oral presentation
- APASL 2007 Kyoto, Mar. 2007, English, The Japan Society of Hepatology (日本肝臓学会), Kyoto, International conferenceGrowing rate of Portal Vein Tumor Thrombus in Patients with Hepatocellular Carcinoma.Poster presentation
- 第68回日本臨床外科学会, Nov. 2006, Japanese, 日本臨床外科学会, 広島, Domestic conference脾静脈塞栓を介した脾浸潤を伴った非機能性膵内分泌腫瘍の1例Others
- 第68回日本臨床外科学会, Nov. 2006, Japanese, 日本臨床外科学会, 広島, Domestic conference当科における生体肝移植後の肝静脈還流障害(Outflow block)に対する静脈ステント留置の治療経験Others
- 第68回日本臨床外科学会, Nov. 2006, Japanese, 日本臨床外科学会, 広島, Domestic conference原発性肝カルチノイド腫瘍の1切除例Others
- 第68回日本臨床外科学会, Nov. 2006, Japanese, 日本臨床外科学会, 広島, Domestic conferenceHCCに対する重粒子線治療施行後にBilomaを形成した1例Oral presentation
- 第42回日本移植学会, Oct. 2006, Japanese, 日本移植学会, 千葉, Domestic conferenceウイルス性肝硬変の生体肝移植における脾摘の意義Poster presentation
- 第42回日本移植学会, Oct. 2006, Japanese, 日本移植学会, 千葉, Domestic conferenceFibrosing cholestatic hepatitis(FCH)による急激なグラフト不全をおこしたC型肝炎陽性生体肝移植2症例Poster presentation
- 第68回日本臨床外科学会, Sep. 2006, Japanese, 日本臨床外科学会, 広島, Domestic conference低用量インターフェロン・リバビリン長期併用療法におけるC型肝炎肝移植後の肝炎制御Others
- 第68回日本臨床外科学会, Sep. 2006, Japanese, 日本臨床外科学会, 広島, Domestic conference成人生体部分肝移植における移植後のグラフト回転に基づいた新しい肝静脈再建法Others
- 第10回日本肝臓学会, Sep. 2006, Japanese, 日本肝臓学会, 札幌, Domestic conference肝細胞癌と異時性・同時性重複癌に対する外科的治療の検討Poster presentation
- 第48回日本消化器病学会大会・第10回日本肝臓学会, Sep. 2006, Japanese, 日本消化器病学会大会・日本肝臓学会, 札幌, Domestic conferenceC型肝炎肝移植後の肝炎再発対策:インターフェロン・リバビリン併用療法の低容量長期投与による肝炎制御Others
- 第42回日本肝癌研究会, Jul. 2006, Japanese, 日本肝癌研究会, 東京, Domestic conference両側門脈腫瘍栓合併多発肝細胞癌に対する門脈腫瘍栓切除を伴う拡大右葉切除術Others
- 第42回日本肝癌研究会, Jul. 2006, Japanese, 日本肝癌研究会, 東京, Domestic conference再発例からみたラジオ波焼灼療法の限界と対策Oral presentation
- 第61回日本消化器外科学会, Jul. 2006, Japanese, 日本消化器外科学会, 神奈川, Domestic conference高度進行肝細胞癌に対する減量肝切除の意義ー門脈腫瘍栓摘出を伴う肝切除手技の工夫Others
- 第61回日本消化器外科学会, Jul. 2006, Japanese, 日本消化器外科学会, 神奈川, Domestic conference肝細胞癌と腹部・消化器重複癌の外科治療成績と問題点Poster presentation
- 第61回日本消化器外科学会, Jul. 2006, Japanese, 日本消化器外科学会, 神奈川, Domestic conference右葉生体肝移植後, 原因不明の肝炎再燃を反復した非B型非C型肝硬変の一例Poster presentation
■ Research Themes
- 学術研究助成基金助成金/基盤研究(C), Apr. 2018 - Mar. 2021Competitive research funding
- 科学研究費補助金/基盤研究(A), Apr. 2017 - Mar. 2021Competitive research funding
- 学術研究助成基金助成金/基盤研究(C), Apr. 2016 - Mar. 2019, Principal investigatorCompetitive research funding
- 学術研究助成基金助成金/挑戦的萌芽研究, Apr. 2016 - Mar. 2019Competitive research funding
- 科学研究費一部基金/基盤研究(B), Apr. 2016 - Mar. 2019Competitive research funding
- 学術研究助成基金助成金/基盤研究(C), Apr. 2016 - Mar. 2019Competitive research funding
- 学術研究助成基金助成金/基盤研究(C), Apr. 2015 - Mar. 2018Competitive research funding
- 国立大学法人九州大学, 感染症実用化研究事業, 2017, Principal investigator(AMED)多施設共同研究による移植後肝炎ウイルス再発に対する標準的治療の確立Competitive research funding
- 国立研究開発法人国立がん研究センター, 革新的がん医療実用化研究事業, 2017, Principal investigator(AMED)Borderline resectable膵癌の集学的治療法確立に関する多施設共同研究Competitive research funding
- 科学研究費一部基金/基盤研究(B)特設, Apr. 2013 - Mar. 2016Competitive research funding
- 肝炎等克服緊急対策研究事業, 2016, Principal investigator(AMED)多施設共同研究による肝移植後肝炎ウイルス新規治療の確立と標準化/C、B型肝炎・肝移植検体収集に関する研究Competitive research funding
- 革新的がん医療実用化研究事業, 2016, Principal investigator(AMED)Borderline resectable膵癌の集学的治療法確立に関する多施設共同研究/臨床試験及び付随研究の中核参加施設Competitive research funding
- 科学研究費補助金/基盤研究(C), Apr. 2012 - Mar. 2015Competitive research funding
- 科学技術振興機構, 研究成果最適展開支援プログラム フィージビリティスタディステージ 探索タイプ, 2015, Principal investigatorA-STEP「腹部・骨盤部悪性腫瘍に対し粒子線治療を可能とするスペーサー技術に応用可能な新規素材の開発」Competitive research funding
- 研究成果最適展開支援プログラム フィージビリティスタディステージ 探索タイプ, 2014, Principal investigatorA-STEP「腹部・骨盤部悪性腫瘍に対し粒子線治療を可能とするスペーサー技術に応用可能な新規素材の開発」Competitive research funding
- 学術研究助成基金助成金/基盤研究(C), 2011Competitive research funding
- 科学研究費補助金/基盤研究(C), 2010, Principal investigatorCompetitive research funding
- 科学研究費補助金/基盤研究(C), 2008Competitive research funding
- 科学研究費補助金/萌芽研究, 2006Competitive research funding
- 生体軟組織固定用デバイスおよびその作製方法(中国)201580048143.2, 09 Sep. 2015, 大学長, ZL201580048143.2, 04 Dec. 2018Patent right
- バルーン用土台及び斜め膨張型バルーンカテーテル特願2017-172769, 30 Mar. 2016, 大学長, 特許6275317, 19 Jan. 2018Patent right
- 斜め膨張型バルーンカテーテル及びバルーン用土台特願2017-513822, 30 Mar. 2016, 大学長, 特許6220102, 06 Oct. 2017Patent right
- 生体軟組織固定用デバイスおよびその作製方法特願2016-546858, 19 May 2016, 大学長, 特許6164675, 30 Jun. 2017Patent right
- 電離放射線治療用スペーサー(フランス)10828230.2, 28 Oct. 2010, 大学長, 2497534, 10 Aug. 2016Patent right
- 電離放射線治療用スペーサー(ドイツ)10828230.2, 28 Oct. 2010, 大学長, 602010035468.7, 10 Aug. 2016Patent right
- 電離放射線治療用スペーサー(スイス)10828230.2, 28 Oct. 2010, 大学長, 2497534, 10 Aug. 2016Patent right
- 電離放射線治療用スペーサー(オランダ)10828230.2, 28 Oct. 2010, 大学長, 2497534, 10 Aug. 2016Patent right
- 電離放射線治療用スペーサー(イタリア)10828230.2, 28 Oct. 2010, 大学長, 2497534, 10 Aug. 2016Patent right
- 電離放射線治療用スペーサー(イギリス)10828230.2, 28 Oct. 2010, 大学長, 2497534, 10 Aug. 2016Patent right
- 電離放射線治療用スペーサー(中)201080049365.3, 28 Oct. 2010, 大学長, ZL201080049365.3, 03 Dec. 2014Patent right
- 電離放射線治療用スペーサー特願2011-539349, 28 Oct. 2010, 大学長, 特許5432281, 13 Dec. 2013Patent right