Research activity information

• Ribonucleic Acid Sequencing Analysis of Intimal Sarcoma of the Large Blood Vessels.

  Suguru Mitsui, Yugo Tanaka, Naoe Jimbo, Hiroyuki Ogawa, Shinya Tane, Daisuke Hokka, Kenji Okada, Yuji Mitomo, Yoshimasa Maniwa

  OBJECTIVES: Intimal sarcoma is a rare vascular malignancy with a poor prognosis and no established treatment. This study aimed to identify clinicopathological and transcriptomic factors associated with disease progression to uncover potential therapeutic targets. METHODS: Ten patients with surgically resected intimal sarcoma were included. Ribonucleic acid (RNA) sequencing was performed on formalin-fixed, paraffin-embedded tumour samples, of which 8 passed quality control. Patients were stratified by the median overall survival of 17 months. Differentially expressed genes (DEGs) were identified and analysed using Gene Ontology (GO), Enrichr, and Gene Set Enrichment Analysis (GSEA). Immunohistochemistry was used to validate selected protein expression. RESULTS: The primary tumour site was the pulmonary artery in 8 cases and the heart in 2 cases. The median survival was 17 months, with a 5-year survival rate of 13.3%. Twenty-eight DEGs (|logFC| > 2, P < 0.01) were identified, most of which were upregulated in poor-prognosis tumours. GO and Enrichr analyses revealed enrichment in ribosome-related processes, including cytoplasmic translation and ribosomal biogenesis. GSEA showed enrichment of MYC targets and oxidative phosphorylation; epithelial-mesenchymal transition was moderately enriched, and myogenesis was downregulated. Immunohistochemistry confirmed overexpression of RPS27 and RPL26 in poor-prognosis tumours. CONCLUSIONS: Transcriptomic analysis revealed upregulation of ribosome-related genes in aggressive intimal sarcoma. Aberrant protein synthesis may contribute to poor prognosis and represent a novel therapeutic vulnerability.

  Aug. 2025, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 67(8) (8), English, International magazine

  Scientific journal


• Novel, noninvasive, extended reality-aided pulmonary tumor marking method for sublobar resection in minimally invasive surgery.

  Ryosuke Izawa, Shinya Tane, Takefumi Doi, Hiroyuki Ogawa, Daisuke Hokka, Yoshimasa Maniwa

  OBJECTIVE: We developed a novel, noninvasive, extended reality-aided marking procedure for tumor localization and aimed to evaluate its feasibility and safety for sublobar resection in minimally invasive surgery. METHODS: We prospectively evaluated the concordance rate between extended reality-aided marking and actual tumor localization for 20 patients who underwent sublobar resection, including wedge resection and segmentectomy. During sublobar resection, the augmented reality image of the 3-dimensional pulmonary anatomy and the tumor were overlaid onto the thoracoscopic monitor. This allowed the surgeons to observe the tumor location with the head-mounted mixed reality display during the surgery. Marking concordance was defined as the difference of 10 mm or less between the distances from the actual tumor margin and the identified marking point on the extended reality to the margin. RESULTS: We enrolled 11 patients who underwent wedge resection and 9 patients who underwent segmentectomy. For each case, the pulmonary anatomy and tumor were successfully overlaid onto the operative image. The median computed tomography tumor size was 13.5 mm (interquartile range, 10.7-21.7 mm). The extended reality-aided marking method accurately delineated 90% of cases (18 of 20). The median distance from the actual surgical margin was 18 mm (interquartile range, 11-23.5 mm). The median duration of surgery was 117 (interquartile range, 64-147) minutes, and the perioperative courses were uneventful for all cases except for paroxysmal atrial fibrillation in 1 patient. CONCLUSIONS: Our novel, noninvasive, extended reality-based marking method is safe and feasible for identifying tumor locations during sublobar resection.

  Aug. 2025, JTCVS techniques, 32, 157 - 162, English, International magazine

  Scientific journal


• Larger polyglycolic acid sheet pleural covering to reduce postoperative recurrence of primary spontaneous pneumothorax.

  Takuya Kohama, Toshihiko Sakamoto, Masayuki Tanahashi, Yoshimasa Maniwa

  BACKGROUND: Post-bullectomy pleural-covering procedures using reinforcement materials, particularly polyglycolic acid (PGA) sheets, are routinely performed to prevent postoperative recurrence of pneumothorax (PORP). However, the optimal size of PGA sheets remains unknown, causing variability in surgical practice. We evaluated the prognostic significance of larger PGA sheets for reducing PORP rates. METHODS: This single-center retrospective study included patients who underwent thoracoscopic bullectomy for primary spontaneous pneumothorax (PSP) between March 2006 and March 2020. Participants were stratified according to the size of the PGA sheets used for pleural covering (large, 225 cm2 and small, 100 cm2). Using Cox proportional hazards regression and inverse probability of treatment weighting (IPTW), the intergroup difference in PORP rates was analyzed to determine the impact of PGA sheet size on postoperative outcomes. RESULTS: In the study cohort with 185 participants, 152 and 33 were assigned to the large and small groups, respectively. PORP incidence was significantly lower in the large group (3.9%, 6/152) than in the small group (12.1%, 4/33), and IPTW-adjusted multivariable Cox regression analysis indicated a significantly reduced recurrence rate in the large group than in the small group (hazard ratio, 0.11, P<0.01). CONCLUSIONS: Using larger PGA sheets to cover the staple line during bullectomy for PSP significantly reduces the postoperative recurrence rate. Adequately sized PGA sheets should be used to provide sufficient coverage beyond the staple line to optimize patient outcomes.

  Jul. 2025, Journal of thoracic disease, 17(7) (7), 4576 - 4586, English, International magazine

  Scientific journal


• Learning curve of consolers and bedside surgeons fused robotic-assisted thoracoscopic segmentectomy: insights from the initial 100 cases.

  Yuki Uno, Shinya Tane, Yugo Tanaka, Midori Takanashi, Takefumi Doi, Hiroyuki Ogawa, Daisuke Hokka, Yoshimasa Maniwa

  PURPOSE: This study examined the learning curve of segmentectomy using the "fused surgery" approach. METHODS: We retrospectively collected data from 100 patients who underwent segmentectomy via fused robot-assisted thoracoscopy at our institution between September 2020 and February 2024. The learning curve was evaluated using the cumulative sum of the operative times in all cases and was analyzed separately for simple and complex segmentectomies. RESULTS: After applying the cumulative sum method to all cases, we obtained a graph of the operative time that showed three well-differentiated phases: phase 1 (n = 23), the initial learning phase; phase 2 (n = 28), the increased competence phase; and phase 3 (n = 49), the highest skill phase. Comparing phases 1 and 2 with phase 3, we found significant differences in operative time (P < 0.001); however, no significant differences were observed in bleeding or rate of postoperative complications. We observed a significant reduction in operative time after 25 simple segmentectomies and 22 complex segmentectomies. CONCLUSIONS: The data suggested that the inflection point of the learning curve was achieved in 51 cases. Complex segmentectomy requires the same cases to achieve the same level of competence as simple segmentectomy.

  Jun. 2025, Surgery today, 55(6) (6), 823 - 829, English, Domestic magazine

  Scientific journal


• Clinical Impact of POU2F3 Expression in Surgically Resected Pulmonary High-Grade Neuroendocrine Carcinoma.

  Suguru Mitsui, Naoe Jimbo, Yugo Tanaka, Hiroyuki Ogawa, Shinya Tane, Daisuke Hokka, Yoshimasa Maniwa

  OBJECTIVE:  High-grade neuroendocrine carcinoma (HGNEC) with dominant POU2F3 expression exhibits non-neuroendocrine features. However, clinical data regarding this subset of pulmonary HGNECs are scarce, and its clinical characteristics remain unclear. METHODS:  Clinicopathological data from 109 patients who underwent surgery for HGNEC were collected and analyzed based on transcription factor expression. Patients were divided into a POU2F3-dominant group (HGNEC-P) and a non-dominant group (HGNEC-non-P) according to immunohistochemical analysis. The clinicopathological characteristics of the two groups were compared, and univariate and multivariate analyses were conducted to identify prognostic factors. RESULTS:  The HGNEC-P group comprised 26 patients, while the HGNEC-non-P group comprised 83 patients. The HGNEC-P group showed significantly lower expression of carcinoembryonic antigen (CEA) (p < 0.001) and a lower rate of vascular invasion (p = 0.021) compared to the HGNEC-non-P group. In addition, the HGNEC-P group exhibited a unique tumor marker profile, with lower serum CEA and higher serum cytokeratin antigen (CYFRA) levels (p < 0.001 and p = 0.046, respectively). Complete resection was achieved in all HGNEC-P cases, whereas only 75.9% of HGNEC-non-P cases achieved complete resection. Multivariate analysis identified POU2F3 expression as an independent prognostic factor for recurrence-free survival (RFS) and disease-specific survival (DSS) (p = 0.037 and p = 0.038, respectively). In patients with pathological Stage I disease, the HGNEC-P group showed significantly better RFS (p = 0.010). CONCLUSIONS:  POU2F3-dominant HGNEC is associated with distinct clinicopathological features and favorable prognosis, particularly in early-stage disease. These findings may support the identification of this subset and inform the development of more effective treatment strategies.

  Apr. 2025, Cureus, 17(4) (4), e82758, English, International magazine

  Scientific journal


• Preoperative risk-factors for secondary spontaneous pneumothorax surgery in Japan: a nationwide database study.

  Ryuichi Waseda, Hiroyuki Yamamoto, Yasushi Shintani, Toshihiko Sato, Kenji Suzuki, Yoshimasa Maniwa, Yukio Sato, Ichiro Yoshino, Masayuki Chida

  PURPOSE: We aimed to identify preoperative risk factors for secondary spontaneous pneumothorax surgery. METHODS: The National Clinical Database of Japan, with six annual datasets from 2014 to 2019, was used. All patients who underwent surgery for secondary spontaneous pneumothorax were included, excluding those < 15 years old and those with incomplete data. The effects of preoperative risk factors were analyzed for operative mortality (mortality during hospitalization or within 30 days, regardless of hospitalization status), 30-day mortality, and postoperative respiratory morbidities. RESULTS: Of the 18,309 patients enrolled in the study, operative mortality, 30-day mortality, and postoperative respiratory morbidities were observed in 654 (3.6%), 343 (1.9%), and 2258 (12.3%) patients, respectively. Increasing age, male sex, body mass index < 18.5 or > 30, performance status > 2, emergent surgery, interstitial pneumonia, and diabetes in preoperative co-morbidity, tumors, and other diseases in underlying lung disease were significant risk factors for operative mortality. Those for 30-day mortality included autoimmune disease instead of male sex and diabetes, while those for postoperative respiratory morbidities included lymphangiomyomatosis instead of a body mass index > 30. CONCLUSION: We identified many preoperative risk factors for operative mortality, 30-day mortality, and postoperative respiratory morbidities in secondary spontaneous pneumothorax surgery. These findings will assist in selecting appropriate surgical candidates.

  Mar. 2025, Surgery today, 55(3) (3), 393 - 404, English, Domestic magazine

  Scientific journal


• Segmentectomy versus lobectomy: does FEV1.0 change accurately reflect the postoperative cardiopulmonary function?

  Yusuke Fujibayashi, Masahiko Takata, Noriaki Tsubota, Yoshimasa Maniwa

  OBJECTIVE: The postoperative respiratory function has been compared between lobectomy and segmentectomy based on the resting spirometric change in many previous studies. However, spirometric change has only been assessed in static conditions, and it is unclear whether it accurately reflects the cardiopulmonary function. METHODS: We used spirometry and a 6-min walk test to evaluate patients who underwent lobectomy and segmentectomy and examined the changes in heart rate (HR), respiratory rate (RR), and saturation of percutaneous oxygen (SpO2) before and after walking between the two groups. RESULTS: The present study included 24 patients who underwent segmentectomy and 21 who underwent lobectomy. There was no significant difference in the reduction of the median forced expiratory volume in 1 s (FEV1.0) after surgery. In the 6-min walk test, the increase in HR and RR after surgery has no significant differences between lobectomy and segmentectomy (HR: p = 0.372 and RR: p = 0.131). However, the two groups showed a significant difference in the reduction of SpO2 (p < 0.001). In addition, correlation analysis found that the more the number of resected segments, the more the reduction of SpO2 with a statistical significance (p = 0.002). CONCLUSIONS: Patients who received segmentectomy showed to suppress the reduction of SpO2 with a statistical difference after the 6-min walk test in comparison to those who received lobectomy. These results suggest that segmentectomy has less impact on the cardiopulmonary function and the 6-min walk test is useful for evaluating the postoperative cardiopulmonary function.

  Feb. 2025, General thoracic and cardiovascular surgery, 73(2) (2), 96 - 101, English, Domestic magazine

  Scientific journal


• Lobectomy Increases Postoperative Pulmonary Artery Enlargement to a Greater Extent than Segmentectomy.

  Megumi Nishikubo, Yugo Tanaka, Shinya Tane, Daisuke Hokka, Yoshimasa Maniwa

  PURPOSE: The underlying mechanism why segmentectomy has demonstrated the non-inferiority to lobectomy in several randomized trials remains unclear. Computed tomography (CT)-measured pulmonary artery (PA) enlargement reflects PA pressure and predicts the prognosis of certain respiratory diseases. We compared the preoperative and postoperative PA diameter to the ascending aorta diameter (PA/A) ratio, investigating its impact on right ventricular function in lung resection. METHODS: This retrospective study was conducted in patients with lower-lobe lung tumors who underwent anatomical lung resection between 2017 and 2022. The PA diameter at the bifurcation and the ascending aorta diameter at the same CT image slice were measured preoperatively and postoperatively. We calculated the enlargement of PA/A ratio (PA/A change) and compared lobectomy and segmentectomy. RESULTS: This analysis included 279 patients (235 with lobectomy and 44 with segmentectomy). The PA/A change was significantly greater in patients with lobectomy than segmentectomy (104% vs. 102%, P = 0.02). In the multivariable analysis, airflow obstruction (yes, P = 0.04) and the type of surgery (segmentectomy, P = 0.04) were independent prognostic factors for PA/A change. CONCLUSIONS: The PA/A change was greater in lobectomy than in segmentectomy. This change could reflect a burden on right ventricular function after lobectomy.

  2025, Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia, 31(1) (1), English, Domestic magazine

  Scientific journal


• Ninjin’yoeito improves respiratory symptoms after lung cancer surgery: a prospective randomized study

  Suguru Mitsui, Yugo Tanaka, Megumi Nishikubo, Takefumi Doi, Shinya Tane, Daisuke Hokka, Takumi Imai, Yoshimasa Maniwa

  Abstract Purpose This study evaluated the efficacy of ninjin’yoeito for alleviating postoperative symptoms after lung cancer surgery. Methods Overall, 140 patients who underwent lobectomy were randomized into a conventional treatment group and a ninjin’yoeito group. The primary endpoint was change in the Cancer Fatigue Scale (CFS) score from baseline and the secondary endpoints were the Cancer Dyspnea Scale (CDS) scores, the Kihon Checklist, and respiratory function. Results The mean change in the CFS score 8 weeks postoperatively was − 5.56 in the ninjin’yoeito group and − 5.53 in the conventional treatment group (P = 0.425), but this outcome did not meet the primary endpoint. Changes in the mean CDS scores 8 weeks postoperatively were − 5.60 and − 3.38 in the ninjin’yoeito and conventional groups, respectively, with a difference of − 1.95 (P = 0.049). The changes in the mean vital capacity 8 weeks postoperatively were − 340.5 mL in the ninjin’yoeito group and − 473.5 mL in the conventional treatment group, with a difference of + 135.1 mL (P = 0.041). The ninjin’yoeito group had a significantly lower proportion of patients with malnutrition 16 weeks postoperatively than the conventional treatment group (P = 0.040). Conclusion The results of this study show that ninjin’yoeito is effective for alleviating respiratory symptoms and improving malnutrition after lung cancer surgery.

  Springer Science and Business Media LLC, Dec. 2024, Surgery Today, 55(5) (5), 693 - 704, English, Domestic magazine

  Scientific journal


• Clinical outcomes of left upper segmentectomy vs. lobectomy for early non-small-cell lung cancer: a nationwide database study in Japan.

  Shinya Tane, Jiro Okami, Yoshimasa Maniwa, Yasushi Shintani, Hiroyuki Ito, Takashi Ohtsuka, Shinichi Toyooka, Takeshi Mori, Shun-Ichi Watanabe, Masayuki Chida, Shunsuke Endo, Ryoichi Nakanishi, Mitsutaka Kadokura, Hidemi Suzuki, Etsuo Miyaoka, Ichiro Yoshino, Hiroshi Date

  PURPOSE: Given that left upper lobe and right upper and middle lobes share a similar anatomy, segmentectomy, such as upper division and lingulectomy, should yield identical oncological clearance to left upper lobectomy. We compared the prognosis of segmentectomy with that of lobectomy for early stage non-small-cell lung cancer (NSCLC) in the left upper lobe. METHODS: We retrospectively examined 2115 patients who underwent segmentectomy or lobectomy for c-stage I (TNM 8th edition) NSCLC in the left upper lobe in 2010. We compared the oncological outcomes of segmentectomy (n = 483) and lobectomy (n = 483) using a propensity score matching analysis. RESULTS: The 5-year recurrence-free and overall survival rates in the segmentectomy and lobectomy groups were comparable, irrespective of c-stage IA or IB. Subset analyses according to radiological tumor findings showed that segmentectomy yielded oncological outcomes comparable to those of lobectomy for non-pure solid tumors. In cases where the solid tumor exceeded 20 mm, segmentectomy showed a recurrence-free survival inferior to that of lobectomy (p = 0.028), despite an equivalent overall survival (p = 0.38). CONCLUSION: Segmentectomy may be an acceptable alternative to lobectomy with regard to the overall survival of patients with c-stage I NSCLC in the left upper lobe.

  Oct. 2024, Surgery today, 54(10) (10), 1162 - 1172, English, Domestic magazine

  Scientific journal


• The expression of YAP1 and other transcription factors contributes to lineage plasticity in combined small cell lung carcinoma.

  Naoe Jimbo, Chiho Ohbayashi, Tomomi Fujii, Maiko Takeda, Suguru Mitsui, Yugo Tanaka, Tomoo Itoh, Yoshimasa Maniwa

  Lineage plasticity in small cell lung carcinoma (SCLC) causes therapeutic difficulties. This study aimed to investigate the pathological findings of plasticity in SCLC, focusing on combined SCLC, and elucidate the involvement of YAP1 and other transcription factors. We analysed 100 surgically resected SCLCs through detailed morphological observations and immunohistochemistry for YAP1 and other transcription factors. Component-by-component next-generation sequencing (n = 15 pairs) and immunohistochemistry (n = 35 pairs) were performed on the combined SCLCs. Compared with pure SCLCs (n = 65), combined SCLCs (n = 35) showed a significantly larger size, higher expression of NEUROD1, and higher frequency of double-positive transcription factors (p = 0.0009, 0.04, and 0.019, respectively). Notably, 34% of the combined SCLCs showed morphological mosaic patterns with unclear boundaries between the SCLC and its partner. Combined SCLCs not only had unique histotypes as partners but also represented different lineage plasticity within the partner. NEUROD1-dominant combined SCLCs had a significantly higher proportion of adenocarcinomas as partners, whereas POU2F3-dominant combined SCLCs had a significantly higher proportion of squamous cell carcinomas as partners (p = 0.006 and p = 0.0006, respectively). YAP1 expression in SCLC components was found in 80% of combined SCLCs and 62% of pure SCLCs, often showing mosaic-like expression. Among the combined SCLCs with component-specific analysis, the identical TP53 mutation was found in 10 pairs, and the identical Rb1 abnormality was found in 2 pairs. On immunohistochemistry, the same abnormal p53 pattern was found in 34 pairs, and Rb1 loss was found in 24 pairs. In conclusion, combined SCLC shows a variety of pathological plasticity. Although combined SCLC is more plastic than pure SCLC, pure SCLC is also a phenotypically plastic tumour. The morphological mosaic pattern and YAP1 mosaic-like expression may represent ongoing lineage plasticity. This study also identified the relationship between transcription factors and partners in combined SCLC. Transcription factors may be involved in differentiating specific cell lineages beyond just 'neuroendocrine'.

  Sep. 2024, The journal of pathology. Clinical research, 10(5) (5), e70001, English, International magazine

  Scientific journal


• Factors affecting the short-term outcomes of robotic-assisted thoracoscopic surgery for lung cancer.

  Yugo Tanaka, Shinya Tane, Takefumi Doi, Suguru Mitsui, Megumi Nishikubo, Daisuke Hokka, Yoshimasa Maniwa

  PURPOSE: Robotic-assisted thoracoscopic surgery (RATS) is a relatively new approach to lung cancer surgery. To promote the development of RATS procedures, we investigated the factors related to short-term postoperative outcomes. METHODS: We analyzed the records of patients who underwent RATS lobectomy for primary lung cancer at our institution between June, 2018 and January, 2023. The primary outcome was operative time, and the estimated value of surgery-related factors was calculated by linear regression analysis. The secondary outcome was surgical morbidity and the risk was assessed by logistic regression analysis. RESULTS: The study cohort comprised 238 patients. Left upper lobectomy had the longest mean operative time, followed by right upper lobectomy. Postoperative complications occurred in 13.0% of the patients. Multivariate analysis revealed that upper lobectomy, the number of staples used for interlobular fissures, and the number of cases experienced by the surgeon were significantly associated with a longer operative time. The only significant risk factor for postoperative complications was heavy smoking. CONCLUSION: Patients with well-lobulated middle or lower lobe lung cancer who are not heavy smokers are recommended for the introductory period of RATS lobectomy. Improving the procedures for upper lobectomy and dividing incomplete interlobular fissures will promote the further development of RATS.

  Aug. 2024, Surgery today, 54(8) (8), 874 - 881, English, Domestic magazine

  Scientific journal


• Clinical and pathological predictors of engraftment for patient-derived xenografts in lung adenocarcinoma.

  Hiroyuki Ogawa, Takamasa Koga, Nhu-An Pham, Nicholas Bernards, Alexander Gregor, Yuki Sata, Shinsuke Kitazawa, Yoshihisa Hiraishi, Tsukasa Ishiwata, Masato Aragaki, Fumi Yokote, Andrew Effat, Kate Kazlovich, Quan Li, Katrina Hueniken, Ming Li, Yoshimasa Maniwa, Ming-Sound Tsao, Kazuhiro Yasufuku

  Patient-derived xenografts (PDXs) are increasingly utilized in preclinical drug efficacy studies due to their ability to retain the molecular, histological, and drug response characteristics of patient tumors. This study aimed to investigate the factors influencing the successful engraftment of PDXs. Lung adenocarcinoma PDXs were established using freshly resected tumor tissues obtained through surgery. Radiological data of pulmonary nodules from this PDX cohort were analyzed, categorizing them into solid tumors and tumors with ground-glass opacity (GGO) based on preoperative CT images. Gene mutation status was obtained from next generation sequencing data and MassARRAY panel. A total of 254 resected primary lung adenocarcinomas were utilized for PDX establishment, with successful initial engraftment in 58 cases (22.8 %); stable engraftment defined as at least three serial passages was observed in 43 cases (16.9 %). The stable engraftment rates of PDXs from solid tumors and tumors with GGO were 22.1 % (42 of 190 cases) and 1.6 % (1 of 64 cases), respectively (P < 0.001). Adenocarcinomas with advanced stage, poor differentiation, solid histologic subtype, and KRAS or TP53 gene mutations were associated with stable PDX engraftment. Avoiding tumors with GGO features could enhance the cost-effectiveness of establishing PDX models from early-stage resected lung adenocarcinomas.

  Aug. 2024, Lung cancer (Amsterdam, Netherlands), 194, 107863 - 107863, English, International magazine

  Scientific journal


• Safety and efficacy of new staple-line reinforcement in lung resection: a prospective study of 48 patients.

  Suguru Mitsui, Yugo Tanaka, Megumi Nishikubo, Takefumi Doi, Shinya Tane, Daisuke Hokka, Yuji Mitomo, Yoshimasa Maniwa

  PURPOSE: To evaluate the safety and efficacy of new staple-line reinforcement (SLR) in pulmonary resection through a prospective study and to compare the results of this study with historical control data in an exploratory study. METHODS: The subjects of this study were 48 patients who underwent thoracoscopic lobectomy. The primary endpoint was air leakage from the staple line. The secondary endpoints were the location of air leakage, duration of air leakage, and postoperative pulmonary complications. RESULTS: The incidence of intraoperative air leakage from the staple line was 6.3%. Three patients had prolonged air leakage as a postoperative pulmonary complication. No malfunction was found in patients who underwent SLR with the stapling device. When compared with the historical group, the SLR group had a significantly lower incidence of air leakage from the staple line (6.3% vs. 28.5%, P < 0.001) and significantly shorter indwelling chest drainage time (P = 0.049) and length of hospital stay (P < 0.001). CONCLUSIONS: The use of SLR in pulmonary resection was safe and effective. When compared with conventional products, SLR could control intraoperative air leakage from the staple line and shorten time needed for indwelling chest drainage and the length of hospital stay.

  Jul. 2024, Surgery today, 54(7) (7), 779 - 786, English, Domestic magazine

  Scientific journal


• Updated outcomes of surgical treatment for recurrent thymic tumour: a report from the Japanese nationwide database.

  Tetsuya Mizuno, Toyofumi Fengshi Chen-Yoshikawa, Ichiro Yoshino, Meinoshin Okumura, Norihiko Ikeda, Koji Kuroda, Yoshimasa Maniwa, Masato Kanzaki, Makoto Suzuki

  OBJECTIVES: This study aimed to analyse the surgical outcomes for recurrent thymic epithelial tumours and identify the factors associated with post-recurrence survival, using an updated Japanese nationwide database. METHODS: The cohort that developed recurrence after the initial resection was extracted from an updated database of patients whose thymic epithelial tumours were treated surgically between 1991 and 2010. Furthermore, we reviewed clinicopathological and prognostic factors of re-resected cases. Post-recurrence survival outcomes and cause-specific deaths in non-re-resected cases were also reviewed. RESULTS: We enrolled 191 patients who underwent re-resection and 259 patients who did not. In the surgery group, more patients with early stage disease, less aggressive World Health Organization (WHO) histological classification, initial complete resection and shorter recurrence-free intervals were included. Non-thymic carcinoma, absence of preoperative treatment, longer recurrent-free interval, single-site recurrence and R0-1 re-resection were all significantly favourable prognostic factors for post-recurrence survival in the surgery group, according to univariable analyses. Non-thymic carcinoma histology, longer recurrence-free interval and R0-1 re-resection were identified as independent prognostic factors according to multivariable analysis. The post-recurrence survival of the entire cohort with R2 re-resection was significantly better than that of the non-surgery group, although it was not demonstrated that patients with thymoma who underwent R2 re-resection had significantly better post-recurrence and lower cause-specific death. CONCLUSIONS: R0-1 re-resection was newly identified as a prognostic factor after re-resection, in addition to non-thymic carcinoma histological classification and longer recurrence-free intervals, as documented in the initial report.

  Jun. 2024, Interdisciplinary cardiovascular and thoracic surgery, 38(6) (6), English, International magazine

  Scientific journal


• Structural basis of Irgb6 inactivation by Toxoplasma gondii through the phosphorylation of switch I.

  Hiromichi Okuma, Yumiko Saijo-Hamano, Hiroshi Yamada, Aalaa Alrahman Sherif, Emi Hashizaki, Naoki Sakai, Takaaki Kato, Tsuyoshi Imasaki, Satoshi Kikkawa, Eriko Nitta, Miwa Sasai, Tadashi Abe, Fuminori Sugihara, Yoshimasa Maniwa, Hidetaka Kosako, Kohji Takei, Daron M Standley, Masahiro Yamamoto, Ryo Nitta

  Irgb6 is a priming immune-related GTPase (IRG) that counteracts Toxoplasma gondii. It is known to be recruited to the low virulent type II T. gondii parasitophorous vacuole (PV), initiating cell-autonomous immunity. However, the molecular mechanism by which immunity-related GTPases become inactivated after the parasite infection remains obscure. Here, we found that Thr95 of Irgb6 is prominently phosphorylated in response to low virulent type II T. gondii infection. We observed that a phosphomimetic T95D mutation in Irgb6 impaired its localization to the PV and exhibited reduced GTPase activity in vitro. Structural analysis unveiled an atypical conformation of nucleotide-free Irgb6-T95D, resulting from a conformational change in the G-domain that allosterically modified the PV membrane-binding interface. In silico docking corroborated the disruption of the physiological membrane binding site. These findings provide novel insights into a T. gondii-induced allosteric inactivation mechanism of Irgb6.

  Jan. 2024, Genes to cells : devoted to molecular & cellular mechanisms, 29(1) (1), 17 - 38, English, International magazine

  Scientific journal


• 【若手外科医のライフハック-仕事・日常・将来を豊かにする,先輩たちの仕事術】日常編 後輩・学生の勧誘 外科においでよ

  小松 昇平, 岡田 健次, 掛地 吉弘, 國久 智成, 尾藤 祐子, 眞庭 謙昌, 福本 巧

  (株)医学書院, Jan. 2024, 臨床外科, 79(1) (1), 44 - 47, Japanese


• Console and bedside surgeon fused robot-assisted thoracic surgery.

  Shinya Tane, Yugo Tanaka, Megumi Nishikubo, Takefumi Doi, Daisuke Hokka, Yoshimasa Maniwa

  In the last decade, even thoracic surgery has seen an increase in the use of robotic surgical systems, and robot-assisted thoracic surgery (RATS) is considered one of the main issues. While RATS is associated with solo manipulative freedom and high-definition optical systems, several disadvantages, such as the lack of tactile sensation and difficult learning curves for the whole team, have been raised. Therefore, to overcome these issues, we developed a 'fusion surgery' approach combining a robotic procedure with manual maneuvers, where the table surgeon retracts the lung and staples the pulmonary vasculature and bronchus. Herein, we introduce our 'fusion surgery' procedure and elaborate on its advantage from technical and educational perspectives.

  Dec. 2023, General thoracic and cardiovascular surgery, 71(12) (12), 730 - 732, English, Domestic magazine

  Scientific journal


• Sarcomatoid mesothelioma diagnosed in a patient with mesothelioma in situ: a case report on morphologic differences after 9-month interval with details analysis of cytology in early-stage mesothelioma.

  Miho Yoshida, Naoe Jimbo, Ryuko Tsukamoto, Tomoo Itoh, Kunimitsu Kawahara, Suguru Mitsui, Yugo Tanaka, Yoshimasa Maniwa

  BACKGROUND: Overlapping morphological features of mesothelial cells have been rendered it difficult to distinguish between reactive and malignant conditions. The development of methods based on detecting genomic abnormalities using immunohistochemistry and fluorescence in situ hybridization have contributed markedly to solving this problem. It is important to identify bland mesothelioma cells on cytological screening, perform efficient genomic-based testing, and diagnose mesothelioma, because the first clinical manifestation of pleural mesothelioma is pleural effusion, which is the first sample available for pathological diagnosis. However, certain diagnostic aspects remain challenging even for experts. CASE PRESENTATION: This report describes a case of a 72-year-old man with a history of asbestos exposure who presented with pleural effusion as the first symptom and was eventually diagnosed as mesothelioma. Mesothelioma was suspected owing to prominent cell-in-cell engulfment in mesothelial cells on the first cytological sample, and the diagnosis of mesothelioma in situ was confirmed by histology. Unexpectedly, sarcomatoid morphology of mesothelioma was found in the second pathology samples 9 months after the first pathological examination. Both the mesothelioma in situ and invasive lesion showed immunohistochemical loss of methylthioadenosine phosphorylase (MTAP) and homozygous deletion of cyclin dependent kinase inhibitor 2A (CDKN2A) on fluorescence in situ hybridization. The patient received medication therapy but died of disease progression 12 months after the diagnosis of the sarcomatoid morphology of mesothelioma. CONCLUSION: Our case suggests that cell-in-cell engulfment can be conspicuous in early-stage mesothelioma with inconspicuous nuclear atypia and few multinucleated cells. In addition, the presence of MTAP loss and CDKN2A homozygous deletion are suspected to be involved in early formation to invasive lesions and/or sarcomatoid morphology. We believe that it is important to consider genetic abnormalities when deciding on individual patient management. Furthermore, cases of mesothelioma, even those of an in situ lesion, with MTAP loss and/or CDKN2A deletion should be carefully followed up or subjected to early treatment.

  Nov. 2023, Diagnostic pathology, 18(1) (1), 126 - 126, English, International magazine

  Scientific journal


• POU2F3-Expressing Small Cell Lung Carcinoma and Large Cell Neuroendocrine Carcinoma Show Morphologic and Phenotypic Overlap

  Naoe Jimbo, Chiho Ohbayashi, Maiko Takeda, Tomomi Fujii, Suguru Mitsui, Ryuko Tsukamoto, Yugo Tanaka, Tomoo Itoh, Yoshimasa Maniwa

  Considering the differences in protein expression in small cell lung carcinoma (SCLC) by molecular classification, it is likely that there are differences in morphology, but the relationship between molecular classification and morphology has not been examined. Furthermore, there are limited reports concerning this molecular classification for large cell neuroendocrine carcinoma (LCNEC) and SCLC simultaneously. Therefore, we investigated the relationship between immunohistochemistry-based molecular classification and morphology, protein expression, and clinical features of 146 consecutive resection specimens of pulmonary neuroendocrine carcinoma (NEC), focusing mainly on POU2F3, the master transcription factor involved in tuft cell generation. POU2F3-dominant SCLC (n=24) and LCNEC (n=14) showed overlap in cytomorphology, while non-POU2F3-dominant SCLC (n=71) and LCNEC (n=37) showed distinct differences in cytomorphology. In addition, POU2F3-dominant NEC exhibited significantly more abundant tumor stroma, more prominent nest formation, more frequent bronchial intraepithelial involvement, and less frequent background fibrosis than non-POU2F3-dominant NEC. Immunohistochemically, POU2F3-dominant SCLC and LCNEC were characterized by lower expression of TTF-1, CEA, and neuroendocrine markers and higher expression of bcl-2, c-Myc, and c-kit. Clinically, POU2F3-dominant NEC had a significantly better prognosis than non-POU2F3-dominant NEC for recurrence-free survival. POU2F3-dominant NEC had a higher smoking index than non-POU2F3-dominant NEC. POU2F3-dominant NEC forms a unique population, exhibiting intermediate morphologic features between SCLC and LCNEC, with distinct protein expression as tuft cell-like carcinoma. Recognition of this unique subtype may provide clues for solving the long-standing issues of NEC and appropriate therapeutic stratification. It is important to accurately identify POU2F3-expressing carcinomas by immunohistochemistry and to analyze their clinicopathological features.

  Ovid Technologies (Wolters Kluwer Health), Oct. 2023, American Journal of Surgical Pathology, 48(1) (1), 4 - 15, English, International magazine

  Scientific journal


• Implication of cytoplasmic p53 expression in pulmonary neuroendocrine carcinoma using next-generation sequencing analysis.

  Naoe Jimbo, Chiho Ohbayashi, Tomomi Fujii, Maiko Takeda, Suguru Mitsui, Ryuko Tsukamoto, Yugo Tanaka, Tomoo Itoh, Yoshimasa Maniwa

  AIMS: Cytoplasmic p53 expression indicates a high frequency of TP53 abnormalities in gynaecological carcinoma. However, the implication of this expression in pulmonary neuroendocrine carcinoma (NEC) remains unclear. Thus, our study aimed to fill this research gap. METHODS AND RESULTS: Immunohistochemistry (IHC) of p53 was performed on 146 cases of resected small-cell lung carcinoma and large-cell NEC, and next-generation sequencing was conducted on cases showing cytoplasmic and wild-type p53 expression. IHC revealed overexpression in 57% of the cases (n = 83), complete absence in 31% (n = 45), cytoplasmic expression in 8% (n = 12) and wild-type expression in 4% (n = 6) of the cases. TP53 mutations were identified in nine of the 13 cases with available genetic analysis. The TP53 mutation rates in cases with cytoplasmic and wild-type p53 expression were 88% (seven of eight) and 40% (two of five), respectively. All seven cases showing cytoplasmic expression with TP53 mutations harboured loss-of-function type mutations: four had mutations in the DNA-binding domain, two in the nuclear localisation domain and one in the tetramerisation domain. Clinically, cases with cytoplasmic p53 expression had a poor prognosis similar to that in cases with p53 overexpression or complete absence. CONCLUSIONS: Cytoplasmic p53 expression in patients with pulmonary NEC suggests a high TP53 mutation rate, which is associated with a poor prognosis similar to that in patients with p53 overexpression or complete absence. This cytoplasmic expression should not be misidentified as a wild-type expression. This is the first report, to our knowledge, that demonstrates the implication of cytoplasmic p53 expression in pulmonary NEC.

  Oct. 2023, Histopathology, 84(2) (2), 336 - 342, English, International magazine

  Scientific journal


• [Perioperative Strategy of Fluid and Nutrition in the Compromised Patients After Lung Resection].

  Shinya Tane, Yoshimasa Maniwa

  The strategy for the administration of fluid and nutrition management after lung resection is not unusual, as compared to the other ordinal surgeries. However, it should be kept in mind that relative reduction in right ventricular function could occur following lung resection due to increased pulmonary vascular resistance. The surgical trauma such as pulmonary arterial clamp and lymphadenectomy as well as the removal of the lung, and perioperative factors such as single lung ventilation, could also increase pulmonary vascular resistance, all of which could be related to acute lung injury. Regarding the fluid management, excessive fluid administration could cause pulmonary edema, decreased alveolar gas permeability, atelectasis, and hypoxia, while restrictive fluid management could induce complication related to hypoperfusion. Since these adverse effects are highly associated with the main causes of morbidity and mortality particularly in the compromised patients, a proper assessment and monitoring of fluid balance (fluid optimization) would be required. In addition, along with the increasing number of the elderly patients, particular concerns must be given to the patients with the sarcopenia or frailty. The appropriate nutritional support following lung surgery is necessary to reduce surgical morbidity and morbidity especially for the malnourished and elderly patients.

  Sep. 2023, Kyobu geka. The Japanese journal of thoracic surgery, 76(10) (10), 870 - 873, Japanese, Domestic magazine

  Scientific journal


• Autocrine TGF-β-positive feedback in profibrotic AT2-lineage cells plays a crucial role in non-inflammatory lung fibrogenesis.

  Yasunori Enomoto, Hiroaki Katsura, Takashi Fujimura, Akira Ogata, Saori Baba, Akira Yamaoka, Miho Kihara, Takaya Abe, Osamu Nishimura, Mitsutaka Kadota, Daisuke Hazama, Yugo Tanaka, Yoshimasa Maniwa, Tatsuya Nagano, Mitsuru Morimoto

  The molecular etiology of idiopathic pulmonary fibrosis (IPF) has been extensively investigated to identify new therapeutic targets. Although anti-inflammatory treatments are not effective for patients with IPF, damaged alveolar epithelial cells play a critical role in lung fibrogenesis. Here, we establish an organoid-based lung fibrosis model using mouse and human lung tissues to assess the direct communication between damaged alveolar type II (AT2)-lineage cells and lung fibroblasts by excluding immune cells. Using this in vitro model and mouse genetics, we demonstrate that bleomycin causes DNA damage and activates p53 signaling in AT2-lineage cells, leading to AT2-to-AT1 transition-like state with a senescence-associated secretory phenotype (SASP). Among SASP-related factors, TGF-β plays an exclusive role in promoting lung fibroblast-to-myofibroblast differentiation. Moreover, the autocrine TGF-β-positive feedback loop in AT2-lineage cells is a critical cellular system in non-inflammatory lung fibrogenesis. These findings provide insights into the mechanism of IPF and potential therapeutic targets.

  Aug. 2023, Nature communications, 14(1) (1), 4956 - 4956, English, International magazine

  Scientific journal


• Uniportal left S1 + 2 segmentectomy.

  Shinya Tane, Yuki Nishioka, Yugo Tanaka, Kazuya Uchino, Wataru Nishio, Yoshimasa Maniwa

  The left upper lobe is one of the largest lobes of the lung; left upper segmentectomy is well established among thoracic surgeons. In uniportal left S1 + 2 segmentectomy, dissection of the vasculature, bronchus, and intersegmental plane can be performed anteriorly. Given that the fissureless technique is commonly used in uniportal video-assisted thoracoscopic surgery, S1 + 2 segmentectomy exhibits high affinity with the unidirectional approach. We have frequently performed left S1 + 2 segmentectomy for early non-small cell lung cancer located in the apical segment, since this procedure has the potential to preserve pulmonary function over tri-segmentectomy. Herein, we introduce our approach to uniportal left S1 + 2 segmentectomy as a minimally invasive alternative for preserving lung function.

  Jul. 2023, General thoracic and cardiovascular surgery, 71(7) (7), 432 - 435, English, Domestic magazine

  Scientific journal


• Programmed death ligand-1 expression and occult lymph node metastasis in non-small cell lung cancer.

  Suguru Mitsui, Yugo Tanaka, Naoe Jimbo, Takefumi Doi, Shinya Tane, Daisuke Hokka, Yoshimasa Maniwa

  BACKGROUND: Identifying the preoperative risk factors for lymph node upstaging could contribute to the development of individualized perioperative treatment for patients with non-small cell lung cancer (NSCLC). The current study aimed to evaluate the risk factors for lymph node upstaging, including gene mutation and programmed death ligand-1 expression in patients with resectable NSCLC. METHODS: Data on the clinicopathological characteristics of patients who underwent lobectomy for clinical N0 NSCLC at our institution were collected. The clinicopathological findings of the pathological N0 and lymph node upstaging groups were then analyzed. Univariate and multivariate analyses were performed to examine the predictive factors for nodal upstaging. RESULTS: Of 291 patients, 40 had postoperative nodal upstaging (n = 25, N1; n = 15, N2). Large tumor size and high maximum standardized uptake value were significantly associated with nodal upstaging. The nodal upstaging group had a higher proportion of patients with solid adenocarcinoma and lymphatic, vascular, and pleural invasion than the pathological N0 group. Further, the nodal upstaging group had a higher proportion of patients with positive programmed death ligand-1 expression than the pathological N0 group. Univariate and multivariate analyses showed that tumor size and positive programmed death ligand-1 expression were associated with nodal upstaging. CONCLUSION: The appropriate therapeutic strategy including preoperative treatment and resection should be cautiously considered preoperatively in patients with clinical N0 NSCLC who have large tumors and positive programmed death ligand-1 expression.

  Jun. 2023, Thoracic cancer, 14(18) (18), 1774 - 1781, English, International magazine

  Scientific journal


• Pulmonary syphilis with a cicatricial variant of organizing pneumonia: a case report.

  Ken Goda, Masahiro Katsurada, Takefumi Doi, Nobuyuki Saga, Yoshimasa Maniwa, Tsuneaki Kenzaka

  BACKGROUND: Syphilis is a chronic disease that progresses in the primary, secondary, latent, and tertiary stages. Pulmonary manifestations of syphilis are rare, and their histological features have not been well-described. CASE PRESENTATION: A 78-year-old man was referred to our hospital because of a solitary nodular shadow in the right middle lung field on a chest radiograph. Five years prior, a rash appeared on both legs. He was tested for syphilis at a public health center, and the non-treponemal test result was negative. When he was approximately 35 years old, he had unspecified sexual intercourse. Chest computed tomography showed a 13-mm nodule with a cavity in S6 of the right lower lobe of the lung. Robot-assisted resection of the right lower lobe was performed because of suspected localized right lower lobe lung cancer. A cicatricial variant of organizing pneumonia (CiOP) was observed, and immunohistochemistry identified Treponema pallidum inside the macrophages in the nodule cavity. The rapid plasma regain (RPR) value was negative, and the Treponema pallidum hemagglutination assay was positive. The patient was diagnosed as having secondary syphilis with pulmonary involvement. Insidious progression of secondary syphilis may result in CiOP and a negative RPR test result. CONCLUSIONS: We report the first case of pulmonary syphilis with a histological pattern of CiOP. It may be asymptomatic and difficult to diagnose because the RPR test may be negative for a long period of time. When either non-treponemal or treponemal test results are positive, the possibility of pulmonary syphilis should be considered along with appropriate medical treatment.

  May 2023, BMC pulmonary medicine, 23(1) (1), 170 - 170, English, International magazine

  Scientific journal


• Targeting of SIRPα as a potential therapy for Langerhans cell histiocytosis.

  Takeshi Okamoto, Yoji Murata, Daiichiro Hasegawa, Makiko Yoshida, Daisuke Tanaka, Takashi Ueda, Daisuke Hazama, Okechi S Oduori, Satomi Komori, Tomoko Takai, Yasuyuki Saito, Takenori Kotani, Yoshiyuki Kosaka, Yoshimasa Maniwa, Takashi Matozaki

  Langerhans cell histiocytosis (LCH) is a rare neoplastic disorder characterized by inflammatory lesions arising from the anomalous accumulation of pathogenic CD1a+ CD207+ dendritic cells (DCs). SIRPα is a transmembrane protein highly expressed in myeloid cells such as DCs and macrophages. Here we show that SIRPα is a potential therapeutic target for LCH. We found that SIRPα is expressed in CD1a+ cells of human LCH lesions as well as in CD11c+ DCs in the spleen, liver, and lung of a mouse model of LCH (BRAFV600ECD11c mouse), in which an LCH-associated active form of human BRAF is expressed in a manner dependent on the mouse Cd11c promoter. BRAFV600ECD11c mice manifested markedly increased numbers of CD4+ T cells, regulatory T cells, and macrophages as well as of CD11c+ MHCII+ DCs in the spleen. Monotherapy with a mAb to SIRPα greatly reduced the percentage of CD11c+ MHCII+ DCs in peripheral blood, LCH-like lesion size in the liver, and the number of CD11c+ MHCII+ DCs in the spleen of the mutant mice. Moreover, this mAb promoted macrophage-mediated phagocytosis of CD11c+ DCs from BRAFV600ECD11c mice, whereas it had no effects on the viability or CCL19-dependent migration of such CD11c+ DCs or on their expression of the chemokine genes Ccl5, Ccl20, Cxcl11, and Cxcl12. Our results thus suggest that anti-SIRPα monotherapy is a promising approach to the treatment of LCH that is dependent in part on the promotion of the macrophage-mediated killing of LCH cells.

  May 2023, Cancer science, 114(5) (5), 1871 - 1881, English, International magazine

  Scientific journal


• The efficacy of thoracoscopic surgery for descending necrotizing mediastinitis.

  Yugo Tanaka, Yoshimasa Maniwa, Kenji Sugio, Tatsuro Okamoto, Ken-Ichi Nibu, Takashi Omori, Shunsuke Endo, Hiroyuki Kuwano, Masayuki Chida, Yasushi Toh, Morihito Okada, Akihiro Shiotani, Ichiro Yoshino

  OBJECTIVES: Thoracotomy is a reliable approach for descending necrotizing mediastinitis (DNM), and the use of video-assisted thoracic surgery (VATS), a minimally invasive procedure, has been increasing. However, which approach is more effective for DNM treatment is controversial. METHODS: We analysed patients who underwent mediastinal drainage via VATS or thoracotomy, using a database with DNM from 2012 to 2016 in Japan, which was constructed by the Japanese Association for Chest Surgery and the Japan Broncho-esophagological Society. The primary outcome was 90-day mortality, and the adjusted risk difference between the VATS and thoracotomy groups using a regression model, which incorporated the propensity score, was estimated. RESULTS: VATS was performed on 83 patients and thoracotomy on 58 patients. Patients with a poor performance status commonly underwent VATS. Meanwhile, patients with infection extending to both the anterior and posterior lower mediastinum frequently underwent thoracotomy. Although the postoperative 90-day mortality was different between the VATS and thoracotomy groups (4.8% vs 8.6%), the adjusted risk difference was almost the same, -0.0077 with 95% confidence interval of -0.0959 to 0.0805 (P = 0.8649). Moreover, we could not find any clinical and statistical differences between the 2 groups in terms of postoperative 30-day and 1-year mortality. Although patients who underwent VATS had higher postoperative complication (53.0% vs 24.1%) and reoperation (37.9% vs 15.5%) rates than those who underwent thoracotomy, the complications were not serious and most could be treated with reoperation and intensive care. CONCLUSIONS: The outcome of DNM treatment does not depend on thoracotomy or VATS.

  Apr. 2023, Interdisciplinary cardiovascular and thoracic surgery, 36(4) (4), English, International magazine

  Scientific journal


• 気管切開にて気管神経鞘腫を摘出した1例

  副島 康平, 土井 健史, 西岡 祐希, 田根 慎也, 法華 大助, 田中 雄悟, 眞庭 謙昌, 手島 直則, 丹生 健一

  (NPO)日本気管食道科学会, Apr. 2023, 日本気管食道科学会会報, 74(2) (2), s28 - s28, Japanese


• 外科医獲得にむけた外科学講座全体での取り組み

  小松 昇平, 岡田 健次, 掛地 吉弘, 國久 智成, 尾藤 祐子, 眞庭 謙昌, 福本 巧

  (一社)日本外科学会, Apr. 2023, 日本外科学会定期学術集会抄録集, 123回, HFT - 3, Japanese


• The dynamic pulmonary functional change after thoracoscopic lower lobe segmentectomy.

  Sanae Kuroda, Shinya Tane, Yoshitaka Kitamura, Yoshimasa Maniwa, Wataru Nishio

  BACKGROUND: The advantages of segmentectomy over lobectomy in sparing pulmonary function remain controversial. Lower lobe segmentectomy is divided into simple segmentectomy, such as segment 6; and complex segmentectomy that includes the basal segments. Here, we compared residual lung function after thoracoscopic segmentectomy versus lobectomy in the lower lobe using the three-dimensional computed tomography volumetric method. METHODS: Between January 2012 and October 2020, 67 patients who underwent thoracoscopic segmentectomy of the lower lobe were matched to 67 patients who underwent thoracoscopic lower lobectomy during the same period using propensity score matching analysis. The postoperative decrease in the rate of forced expiratory volume in 1 s was compared between methods. The regional forced expiratory volume in 1 s of the residual lobe rescued by segmentectomy was measured using volumetric and spirometric analyses and compared to lower lobectomy. The ratio of the actual to predicted postoperative forced expiratory volume in 1 s in the residual lobe was defined as the preservation rate. RESULTS: Of the 67 thoracoscopic segmentectomies, 43 were S6, seven were S8, three were S8  +  9, seven were S10, and seven were S9  +  10. The percentage of postoperative/preoperative forced expiratory volume in 1 s was significantly higher in the segmentectomy versus lobectomy group (90.7% vs. 85.7%, p  =  0.001). The preservation rates after simple segmentectomy (n  =  43) and complex segmentectomy (n  =  24) did not differ significantly (82.2% vs. 80.2%, p  =  0.709). CONCLUSIONS: Thoracoscopic lower lobe segmentectomy versus lobectomy preserves postoperative lung function. Even complex segmentectomy exhibited outcomes relevant to simple segmentectomy by sparing the residual lobe.

  Mar. 2023, Asian cardiovascular & thoracic annals, 31(3) (3), 229 - 237, English, International magazine

  Scientific journal


• Chorioallantoic membrane assay revealed the role of TIPARP (2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible poly (ADP-ribose) polymerase) in lung adenocarcinoma-induced angiogenesis

  Kenji Miura, Michiyo Koyanagi-Aoi, Yoshimasa Maniwa, Takashi Aoi

  Abstract Background The chorioallantoic membrane (CAM) assay is a well-established technique to evaluate tumor invasion and angiogenesis and may overcome the shortcoming of the patient-derived xenograft (PDX) mouse model. Currently, few reports have described lung cancer invasion and angiogenesis in the CAM assay. We therefore used the CAM assay in the evaluation of lung cancer. Method Lung cancer cell line-derived organoids or lung cancer cell lines were transplanted into the CAM on embryonic development day (EDD) 10, and an analysis was performed on EDD 15. Microscopic and macroscopic images and movies of the grafts on the CAM were captured and analyzed. The relationships between the graft and chick vessels were evaluated using immunohistochemistry. Results We transplanted lung cancer cell lines and cell line-derived organoid into a CAM to investigate angiogenesis and invasion. They engrafted on the CAM at a rate of 50–83%. A549-OKS cells showed enhanced cell invasion and angiogenesis on the CAM in comparison to A549-GFP cells as was reported in vitro. Next, we found that A549-TIPARP cells promoted angiogenesis on the CAM. RNA-seq identified 203 genes that were upregulated more than twofold in comparison to A549-GFP cells. A pathway analysis revealed many upregulated pathways related to degradation and synthesis of the extracellular matrix in A549-TIPARP cells. Conclusions The CAM assay can be used to evaluate and research invasion and angiogenesis in lung cancer. The elevated expression of TIPARP in lung cancer may induce angiogenesis by remodeling the extracellular matrix.

  Springer Science and Business Media LLC, Feb. 2023, Cancer Cell International, 23(1) (1), 34 - 34, English, International magazine

  Scientific journal


• Comparable efficacy and safety of COVID-19 vaccines for patients receiving tegafur-uracil as postoperative adjuvant chemotherapy.

  Megumi Nishikubo, Yugo Tanaka, Suguru Mitsui, Takefumi Doi, Daisuke Hokka, Wataru Hojo, Hironori Sakai, Yohei Funakoshi, Kimikazu Yakushijin, Goh Ohji, Hironobu Minami, Yoshimasa Maniwa

  PURPOSE: Many effective vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been developed, but a weaker response in individuals undergoing anticancer treatment has been reported. This study evaluates the immunogenic status and safety of SARS-CoV-2 vaccines for patients with non-small-cell lung cancer (NSCLC), receiving tegafur-uracil (UFT) as postoperative adjuvant chemotherapy. METHODS: The subjects of this prospective study were 40 patients who underwent surgery for NSCLC and received SARS-CoV-2 vaccines postoperatively. We compared the antibody titers of SARS-CoV-2 vaccines and the adverse events between patients who received adjuvant UFT and patients who did not. RESULTS: The mean anti-S1 IgG titers were not significantly different between the UFT and without-UFT groups (mean optimal density, 0.194 vs. 0.205; P = 0.76). Multivariate analysis identified the period after the second vaccination as an independent predictor of anti-S1 IgG titer (P = 0.049), but not the UFT status (with or without-UFT treatment; P = 0.47). The prevalence of adverse events did not differ significantly between the groups, and no severe adverse events occurred. CONCLUSIONS: The efficacy and safety of the SARS-CoV-2 vaccines for NSCLC patients who received postoperative adjuvant UFT chemotherapy were comparable to those for NSCLC patients who did not receive postoperative adjuvant UFT chemotherapy. CLINICAL TRIAL REGISTRATION: This study was registered with the University Hospital Medical Information Network (UMIN) in Japan (UMIN000047380).

  Feb. 2023, Surgery today, 53(9) (9), 1 - 7, English, Domestic magazine

  Scientific journal


• Intraoperative rapid immunohistochemistry with noncontact antibody mixing for undiagnosed pulmonary tumors.

  Kazuhiro Imai, Hiroshi Nanjo, Wataru Shigeeda, Tamotsu Sugai, Tomoo Ito, Yoshimasa Maniwa, Shinogu Takashima, Hajime Saito, Naoki Yanagawa, Yugo Tanaka, Takefumi Doi, Yuko Hiroshima, Kyoko Nomura, Mishie Tanino, Shinya Tanaka, Yoshihiro Minamiya

  Knowledge of the histologic type and primary origin of pulmonary tumors is essential when preparing a surgical strategy. Intraoperative diagnosis of hematoxylin and eosin (H&E)-stained frozen sections is the gold standard, but reliable pathology requires time-consuming immunohistochemistry (IHC) to distinguish among histological types/organ origins and to analyze molecular status. The aim of this study was to evaluate the clinical reliability of a new rapid-IHC technique for intraoperative diagnosis of pulmonary tumors. In total, 169 patients with undiagnosed pulmonary tumors were enrolled in a multicenter prospective observational study. At three institutes, pulmonary tumor samples were collected through core needle biopsy and/or surgery to determine surgical strategies. Using a new device for rapid IHC, we applied a high-voltage, low-frequency alternating current (AC) field, which mixes the available antibody as the voltage is switched on/off. Rapid IHC can provide tumor histologic type/origin diagnoses within 20 min, as opposed to the 3-6 h required for conventional IHC. No false diagnoses of malignancy were rendered in any of the cases when using simple H&E staining. With H&E staining alone, the overall definitive diagnosis rate, the rate of defined tumor origin, and the rate of determined histological type were 76.92%, 85.80%, and 90.53%, respectively. When rapid IHC was added, those rates were significantly improved to 88.76%, 94.67%, and 91.72%, respectively. By providing prompt and accurate intraoperative histological/molecular analysis, rapid IHC driven by AC mixing could serve as an effective clinical tool guiding the surgical strategy for undiagnosed pulmonary tumors.

  Feb. 2023, Cancer science, 114(2) (2), 702 - 711, English, International magazine

  Scientific journal


• 外科発展の礎 外科志望者増加のための取り組み 外科医獲得にむけた神戸大学外科学講座の取り組み

  小松 昇平, 岡田 健次, 掛地 吉弘, 國久 智成, 尾藤 祐子, 眞庭 謙昌, 福本 巧

  (一社)日本外科学会, Jan. 2023, 日本外科学会雑誌, 124(1) (1), 106 - 108, Japanese


• Prediction of infectivity of SARS-CoV2: Mathematical model with analysis of docking simulation for spike proteins and angiotensin-converting enzyme 2.

  Yutaka Takaoka, Aki Sugano, Yoshitomo Morinaga, Mika Ohta, Kenji Miura, Haruyuki Kataguchi, Minoru Kumaoka, Shigemi Kimura, Yoshimasa Maniwa

  OBJECTIVES: Variants of a coronavirus (SARS-CoV-2) have been spreading in a global pandemic. Improved understanding of the infectivity of future new variants is important so that effective countermeasures against them can be quickly undertaken. In our research reported here, we aimed to predict the infectivity of SARS-CoV-2 by using a mathematical model with molecular simulation analysis, and we used phylogenetic analysis to determine the evolutionary distance of the spike protein gene (S gene) of SARS-CoV-2. METHODS: We subjected the six variants and the wild type of spike protein and human angiotensin-converting enzyme 2 (ACE2) to molecular docking simulation analyses to understand the binding affinity of spike protein and ACE2. We then utilized regression analysis of the correlation coefficient of the mathematical model and the infectivity of SARS-CoV-2 to predict infectivity. RESULTS: The evolutionary distance of the S gene correlated with the infectivity of SARS-CoV-2 variants. The calculated biding affinity for the mathematical model obtained with results of molecular docking simulation also correlated with the infectivity of SARS-CoV-2 variants. These results suggest that the data from the docking simulation for the receptor binding domain of variant spike proteins and human ACE2 were valuable for prediction of SARS-CoV-2 infectivity. CONCLUSION: We developed a mathematical model for prediction of SARS-CoV-2 variant infectivity by using binding affinity obtained via molecular docking and the evolutionary distance of the S gene.

  Dec. 2022, Microbial risk analysis, 22, 100227 - 100227, English, International magazine

  Scientific journal


• Segmental volumetric analysis with a ventilated or perfused area: identifying the intersegmental plane.

  Mai Kitazume, Shinya Tane, Nahoko Shimizu, Yoshitaka Kitamura, Yoshimasa Maniwa, Wataru Nishio

  OBJECTIVES: Two methods are available to identify the intersegmental plane during segmentectomy: the inflation-deflation method, based on the ventilation area, and injection of indocyanine green, based on the pulmonary arterial distribution. However, whether the intersegmental plane created by these 2 methods matches remains unknown. Our goal was to identify the demarcation lines based on bronchial and arterial territories using 3-dimensional computed tomography-based volumetry. METHODS: We collected data from patients who underwent thoracoscopic segmentectomy in our hospital between April 2012 and May 2021. Three-dimensional images were reconstructed from the preoperative contrast-enhanced computed tomography data using the SYNAPSE VINCENT software program. The volume of the affected area and the distance of the tumour from the intersegmental plane were calculated based on each affected artery and bronchus. Each calculated volume was compared to each affected segment using a paired t-test. RESULTS: Of 195 patients, 114 underwent upper lobe segmentectomy, and 81 underwent lower lobe segmentectomy. In upper lobe segmentectomy, the affected arterial segmental volume was smaller than the bronchial volume (505.0 ml vs 539.4 ml, P < 0.001). In lower lobe segmentectomy, there was no significant difference between arterial and bronchial volumes (234.6 ml vs 236.9 ml, P = 0.607). The volume of the affected arterial segmental lung and the distance of the tumour from the intersegmental plane were significantly smaller than the bronchial volume in upper lobe segmentectomies. CONCLUSIONS: As per the results, the affected segmental volume delineated by the indocyanine green method would be underestimated in upper lobe segmentectomy.

  Nov. 2022, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 62(6) (6), English, International magazine

  Scientific journal


• Effect of myasthenia gravis on the surgical outcomes of patients with thymoma.

  Kenji Miura, Takefumi Doi, Yugo Tanaka, Daisuke Hokka, Naoe Jimbo, Tomoo Itoh, Yoshimasa Maniwa

  BACKGROUND: Myasthenia gravis (MG) is the most common paraneoplastic syndrome in thymoma. However, the association between MG and postoperative outcomes is controversial. Therefore, we examined the effect of MG on the surgical outcomes of patients with thymoma. METHODS: This study enrolled 145 consecutive patients with thymoma who underwent surgical resection at our institution between January 2000 and December 2020. The patients were classified into thymoma with MG (MG group) and without MG (non-MG group). Data about characteristics of patients, surgical outcomes, and prognostic factors were compared between the two groups. RESULTS: Of 145 patients, 47 (32%) presented with MG and 98 (68%) did not. There was no significant difference in terms of the incidence of postoperative complications, overall survival (OS), and recurrence-free survival (RFS) between the two groups. The deaths were not caused by thymoma. Among the patients aged >60 years, the MG group had a lower survival rate than the non-MG group. In the univariate analysis, age ≥60 years was a poor prognostic factor for OS, whereas in the multivariate analysis, Masaoka stage III and IV classifications were poor prognostic factors for RFS. CONCLUSION: The incidence of postoperative complications did not differ between patients with thymoma and without MG. In the MG group, age ≥60 years was a poor prognostic factor for OS. The postoperative follow-up of patients aged ≥60 years with thymoma with MG should focus on not only recurrence but also progression of diseases other than thymoma.

  Oct. 2022, Asian cardiovascular & thoracic annals, 30(8) (8), 924 - 930, English, International magazine

  Scientific journal


• 進行肺扁平上皮癌の治療経過中に良性の多発リンパ節腫大と再考し切除した1例

  伊賀 脩介, 桂田 直子, 立原 素子, 山本 正嗣, 小林 和幸, 光井 卓, 田中 雄悟, 眞庭 謙昌, 田中 伴典

  (NPO)日本肺癌学会, Oct. 2022, 肺癌, 62(5) (5), 444 - 444, Japanese


• Pericardiotomy under clamshell approach for large posterior mediastinal sarcoma: a case report.

  Nahoko Shimizu, Yugo Tanaka, Sanae Kuroda, Takeshi Inoue, Yoshimasa Maniwa

  BACKGROUND: Large mediastinal tumors are sometimes difficult to completely resect because they are surrounded by vital organs. We present the case of mediastinal liposarcoma successfully resected by the clamshell approach with a posterior pericardial wall incision. CASE PRESENTATION: An 81-year-old man visited the hospital because of a prolonged cough. Imaging studies revealed a large tumor of the left posterior mediastinum. The tumor surrounded the left inferior pulmonary vein and was suspected of invading the left lower lobe and esophagus. Complete resection of a large mediastinal tumor invading the left inferior pulmonary vein and esophagus was achieved by adding a posterior pericardial wall incision to the clamshell approach under cardiopulmonary bypass. Histopathological diagnosis was well-differentiated liposarcoma. Postoperative course was good, and the patient is alive without any sign of recurrence for 53 months. CONCLUSIONS: This approach could represent a novel method to safely and effectively remove large mediastinal tumors invading the lung and esophagus.

  Sep. 2022, General thoracic and cardiovascular surgery cases, 1(1) (1), 5 - 5, English, International magazine

  Scientific journal


• Sarcomatoid mesothelioma originating from mesothelioma in situ: are methylthioadenosine phosphorylase loss and CDKN2A homozygous deletion poor prognostic factors for preinvasive mesothelioma?

  Megumi Nishikubo, Naoe Jimbo, Yugo Tanaka, Motoko Tachihara, Tomoo Itoh, Yoshimasa Maniwa

  The diagnosis of mesothelioma in situ (MIS) is challenging with conventional diagnostic approaches. Although recent advances in genomic-based assays have made it possible to diagnose MIS, the prognosis, treatment indications, and prognostic factors remain unclear. Previous reports have shown that MIS progresses to invasive mesothelioma; however, to the best of our knowledge, progression to sarcomatoid mesothelioma has not yet been reported. A 73-year-old man was diagnosed with MIS associated with methylthioadenosine phosphorylase (MTAP) loss and a CDKN2A homozygous deletion. Strikingly, pathological examination revealed that the MIS lesion had progressed to sarcomatoid mesothelioma. In analyses of previously reported cases and our case, MIS with a CDKN2A homozygous deletion or MTAP loss progressed to invasive mesothelioma earlier than that without them, indicating that a CDKN2A homozygous deletion and MTAP loss could be poor prognostic factors. Genomic analyses might be useful for predicting the prognosis of MIS and contributing to an optimal treatment.

  Aug. 2022, Virchows Archiv : an international journal of pathology, 481(2) (2), 307 - 312, English, International magazine

  Scientific journal


• Prognostic value of preoperative plasma fibrinogen levels in resected stage I non-small cell lung cancer.

  Suguru Mitsui, Yugo Tanaka, Takefumi Doi, Daisuke Hokka, Yoshimasa Maniwa

  BACKGROUND: The number of surgical procedures has increased among patients with early-stage lung cancer. If the poor prognostic factors for stage I non-small cell lung cancer (NSCLC) can be simply validated preoperatively, appropriate treatment will be provided. The current study aimed to evaluate the prognostic value of preoperative plasma fibrinogen levels in patients with resected stage I NSCLC. METHODS: We retrospectively analyzed the clinicopathological information of patients (n = 149) who underwent lobectomy for stage I NSCLC between May 2014 and July 2016. Data about peripheral blood analysis, histopathological finding, and follow-up assessment results were collected from the databases. Patients were divided into the low and high fibrinogen groups. Univariate and multivariate analyses were performed to evaluate the predictors of recurrence and survival. RESULTS: Compared with the low fibrinogen group (<377 mg/dl), the high fibrinogen group (≥377 mg/dl) had a significantly greater number of male participants (p = 0.04), smokers (p < 0.001), and those with elevated cytokeratin antigen levels (p = 0.04), lymphatic invasion (p = 0.007), and squamous cell carcinoma (p < 0.001). Plasma fibrinogen level was considered a significant independent factor for recurrence and overall survival on both the univariate and multivariate analyses (p < 0.001 and p = 0.010) and the multivariate analysis alone (p = 0.020 and p < 0.012). CONCLUSION: Preoperative plasma fibrinogen level might be a useful predictor of recurrence and survival in patients with stage I NSCLC. The treatment strategy for patients with high fibrinogen levels could be cautiously considered preoperatively.

  May 2022, Thoracic cancer, 13(10) (10), 1490 - 1495, English, International magazine

  Scientific journal


• 外科医獲得にむけた神戸大学外科学講の取り組み

  小松 昇平, 岡田 健次, 掛地 吉弘, 谷野 裕一, 尾藤 祐子, 眞庭 謙昌

  (一社)日本外科学会, Apr. 2022, 日本外科学会定期学術集会抄録集, 122回, SP - 8, Japanese


• Annexin A10 Expression as a Novel Prognostic Marker in Lung Adenocarcinoma.

  Masako Yumura, Tatsuya Nagano, Naoe Jimbo, Ryota Dokuni, Tatsunori Kiriu, Yugo Tanaka, Motoko Tachihara, Tomoo Itoh, Yoshimasa Maniwa, Yoshihiro Nishimura, Kazuyuki Kobayashi

  BACKGROUND/AIM: Annexin A10 (ANXA10) is a member of the annexin family and a calcium-dependent phospholipid-binding protein. The aim of this study was to clarify the clinical significance of ANXA10 expression in lung adenocarcinoma. MATERIALS AND METHODS: ANXA10 expression was immunohistochemically examined in surgical specimens of lung adenocarcinoma obtained from 74 consecutive patients who underwent complete resection from January 2014 to December 2014. Expression of ANXA10 was down-regulated in A549 cells via siRNA transfection and the effect of ANXA10 on cell migration was assessed by the wound healing assay. Expression of ANXA10 was examined by immunocytochemistry and polymerase chain reaction. RESULTS: High ANXA10 expression was significantly correlated with poor overall survival (p=0.00705). Multivariate analysis with the Cox proportional hazard model demonstrated that ANXA10 expression was an independent prognostic factor. Cell migration was suppressed in ANXA10-down-regulated A549 cell lines. CONCLUSION: ANXA10 has a role in cancer cell migration and high ANXA10 expression is a novel prognostic marker in lung adenocarcinoma.

  Mar. 2022, Anticancer research, 42(3) (3), 1289 - 1294, English, International magazine

  Scientific journal


• Oxidized Regenerated Cellulose Sheets in Postoperative Intrathoracic Adhesions.

  Daisuke Hokka, Yugo Tanaka, Nahoko Shimizu, Takefumi Doi, Yoshimasa Maniwa

  Adhesiolysis is often necessary in intrathoracic adhesion during ipsilateral repeat lung resection. This procedure has a risk of surgical complications, including unintentional intraoperative damage of the pulmonary vessels or lung parenchyma. We used an oxidized regenerated cellulose (ORC) sheet to prevent intrathoracic adhesion after lung resection in 55 patients. The sheet was placed on the surface of the resected region and on the lung surface under the wound. No major postoperative complications were observed. Three cases underwent ipsilateral thoracic surgery for the treatment of lung malignancies, and there were no intrathoracic adhesions around the ORC sheet-covered area.

  Feb. 2022, Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia, 28(1) (1), 32 - 35, English, Domestic magazine

  Scientific journal


• ROS1-Rearranged Lung Cancer Successfully Resected after Response to Crizotinib: A Case Report.

  Nahoko Shimizu, Yugo Tanaka, Motoko Tachihara, Yoshimasa Maniwa

  The usefulness of molecularly targeted therapy as a preoperative therapy for the c-ros oncogene 1 receptor tyrosine kinase (ROS1)-rearranged lung cancer has not been established. We present the case of ROS1- rearranged lung cancer successfully resected after response to crizotinib. The patient was a 71-year-old woman with prolonged cough. She was diagnosed with ROS1-rearranged lung adenocarcinoma (cT4N2M0, stage IIIB). After eight weeks of crizotinib treatment, right upper lobectomy with chest wall resection, angioplasty, and bronchoplasty were performed. The postoperative course was good, and the patient survived for 41 months after the surgery without recurrence. Surgical resection after molecularly targeted therapy for ROS1-positive lung cancer may lead to good local control.

  Feb. 2022, The Kobe journal of medical sciences, 67(4) (4), E143-E145, English, Domestic magazine

  Scientific journal


• Preoperative Cumulative Smoking Dose on Lung Cancer Surgery in a Japanese Nationwide Database.

  Yugo Tanaka, Hiroyuki Yamamoto, Masami Sato, Shinichi Toyooka, Morihito Okada, Shunsuke Endo, Yukio Sato, Kenji Suzuki, Yoshimasa Maniwa, Eriko Fukuchi, Hiroaki Miyata, Masayuki Chida

  BACKGROUND: Smoking is a known risk factor for postoperative mortality and morbidity. However, the significance of cumulative smoking dose in preoperative risk assessment has not been established. We examined the influence of preoperative cumulative smoking dose on surgical outcomes after lobectomy for primary lung cancer. METHODS: A total of 80,989 patients with primary lung cancer undergoing lobectomy from 2014 to 2016 were enrolled. Preoperative cumulative smoking dose was categorized by pack-years (PY): nonsmokers, PY = 0; light smokers, 0 < PY < 10; moderate smokers, 10 ≤ PY < 30; and heavy smokers, 30 ≤ PY. The risk of short-term outcomes was assessed according to PY by multivariable analysis adjusted for other covariates. RESULTS: Postoperative 30-day mortality, as well as pulmonary, cardiovascular, and infectious complications, increased with preoperative PY. Multivariable analysis revealed that the odds ratios (ORs) for postoperative mortality compared with nonsmokers were 1.76 for light smokers (P = .044), 1.60 for moderate smokers (P = .026), and 1.73 for heavy smokers (P = .003). The ORs for pulmonary complications compared with nonsmokers were 1.20 for light smokers (P = .022), 1.40 for moderate smokers (P < .001), and 1.72 for heavy smokers (P < .001). Heavy smokers had a significantly increased risk of postoperative cardiovascular (OR, 1.26; P = .002) and infectious (OR, 1.39; P = .007) complications compared with nonsmokers. CONCLUSIONS: The risk of mortality and morbidity after lung resection could be predicted according to preoperative cumulative smoking dose. These findings contribute to the development of strategies in perioperative management of lung resection patients.

  Jan. 2022, The Annals of thoracic surgery, 113(1) (1), 237 - 243, English, International magazine

  Scientific journal


• Successful treatment of phrenic nerve injury with diaphragmatic plication 5 years after onset: A case report.

  Chihiro Ohashi, Takahiro Uchida, Yugo Tanaka, Yoshimasa Maniwa

  Diaphragmatic paralysis due to phrenic nerve injury is an occasional complication of cardiothoracic surgery. Although diaphragmatic plication is widely used to treat patients with severe irreversible symptoms, its surgical indication and timing remain controversial. Here, we present a rare case of diaphragmatic paralysis in a 65-year-old woman who underwent cardiac surgery and whose respiratory symptoms worsened despite >5 years of conservative management. Consequently, she underwent diaphragmatic plication using an endostapler to resect the redundant diaphragm, followed by over-suturing of all staple lines. She was discharged without any complications and her symptoms and chest radiography and spirometry results improved postoperatively.

  2022, SAGE open medical case reports, 10, 2050313X211070514, English, International magazine

  Scientific journal


• Chloride Intracellular Channel 1 Expression Is Associated With Poor Prognosis of Lung Adenocarcinoma.

  Yuichiro Yasuda, Tatsuya Nagano, Naoe Jimbo, Tatsunori Kiriu, Ratoe Suraya, Daisuke Hazama, Masatsugu Yamamoto, Yoshimasa Maniwa, Yoshihiro Nishimura, Kazuyuki Kobayashi

  BACKGROUND/AIM: Chloride intracellular channel 1 (CLIC1) is a member of the chloride channel protein family. The aim of this study was to clarify the role of CLIC1 in lung adenocarcinoma. PATIENTS AND METHODS: The expression levels of CLIC1 in 74 patients with completely resected lung adenocarcinoma were analyzed by immunohistochemistry. Overall survival was assessed in relation to the expression level of CLIC1. Moreover, in the lung cancer cell lines A549 and PC9, CLIC1 expression was inhibited by small interfering RNA. The function of CLIC1 was analyzed in these cell lines. RESULTS: High expression of CLIC1 was associated with short overall survival compared to low expression (p=0.0327). Multivariate analysis revealed that CLIC1 expression was an independent prognostic factor. Knockdown of CLIC1 inhibited cell proliferation and migration through suppression of the p38 MAPK signaling pathway in A549 and PC9 cells. CONCLUSION: CLIC1 may be a useful prognostic factor in lung adenocarcinoma.

  Jan. 2022, Anticancer research, 42(1) (1), 271 - 277, English, International magazine

  Scientific journal


• Multicentre prospective observational study for pulmonary vein stump thrombus after anatomical lung resections.

  Aritoshi Hattori, Kazuya Takamochi, Satoshi Shiono, Masahiro Tsuboi, Yoshimasa Maniwa, Kazuhiro Suzuki, Kenji Suzuki

  OBJECTIVES: Our goal was to evaluate the incidence and frequent sites of pulmonary vein stump thrombus (PVST) formation after pulmonary resection. METHODS: This is a prospective multicentre observational study conducted by 14 institutions in Japan. Enrolled patients underwent anatomical pulmonary resection including lobectomy, bilobectomy, pneumonectomy, left upper trisegmentectomy or lingular segmentectomy. Postoperative contrast-enhanced computed tomography was performed in the early period after the pulmonary resection to evaluate the incidence of PVST. Furthermore, univariable and multivariable analyses were performed to assess the risk factors associated with PVST using a logistic regression model. RESULTS: The status of PVST based on postoperative contrast-enhanced computed tomography scans was prospectively evaluated for 1040 patients. Postoperative computed tomography evaluation was performed for 3 (range: 1-84) days on average after the pulmonary resection. PVST was found in 127 (12.2%) patients with left-sided (23.3%) predominance compared to the right side (4.9%) (P < 0.001). Furthermore, left upper lobectomy was the most frequent operative procedure (30.8%). Multivariable analyses demonstrated that left upper lobectomy (P = 0.001) and left-sided pulmonary resection (P < 0.001) were independent significant predictors of PVST. Cerebral infarction was observed in 9 (0.87%) patients during this period and included 6 (1.46%) in whom it developed after the operation was performed on the left side. Especially in the early postoperative phase, left pulmonary resection was significantly associated with the incidence of cerebral infarction (0.16% vs 1.21%; P = 0.028). CONCLUSIONS: PVST is an early postoperative event that is frequently observed in patients undergoing left anatomical pulmonary resection, especially a left upper lobectomy. IRB NUMBER: 16-205, Clinical trial registry: UMIN000027118.

  Dec. 2021, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 61(1) (1), 92 - 99, English, International magazine

  Scientific journal


• The effect of home-based preoperative pulmonary rehabilitation before lung resection: A retrospective cohort study.

  Takashi Saito, Rei Ono, Yugo Tanaka, Daisuke Tatebayashi, Maho Okumura, Daisuke Makiura, Junichiro Inoue, Takashi Fujikawa, Shin Kondo, Tatsuro Inoue, Yoshimasa Maniwa, Yoshitada Sakai

  OBJECTIVES: This study aimed to assess the effect of home-based preoperative pulmonary rehabilitation (HBPPR) on the incidence of postoperative complications, length of stay (LOS), and duration of intercostal catheterization in non-small cell lung cancer (NSCLC) patients who underwent lung resection. MATERIALS AND METHODS: In this retrospective cohort study, 144 patients who underwent lung resection were recruited, 51 of whom received HBPPR, comprising respiratory muscle training and was supervised (for patients undergoing it for the first time). Patients continued these programs for 2-4 weeks during the preoperative waiting period, in their homes. Data on postoperative complications graded according to the Clavien-Dindo classification, LOS, and intercostal catheterization duration were collected from medical records. These outcomes were compared between the HBPPR and non-HBPPR groups using Fisher's exact test and Wilcoxon rank sum test, after 1:1 propensity score matching to avoid selection bias. RESULTS: Forty-nine matched pairs were extracted using propensity score matching. HBPPR reduced the onset of postoperative complications (p = 0.04), with the relative ratio (RR) for Clavien-Dindo Class I postoperative complications showing a significant difference (RR 0.55, 95% CI 0.30-1.02; p = 0.05), whereas RRs for the other Clavien-Dindo classes were not statistically significant. There was no significant difference in LOS or the duration of intercostal catheterization. CONCLUSION: HBPPR reduced the incidence of Clavien-Dindo Class I postoperative complications after lung resection. Implementing HBPPR practices in a clinical setting would benefit patients unable to receive supervised preoperative pulmonary rehabilitation due to access barriers, time, and financial constraints.

  Dec. 2021, Lung cancer (Amsterdam, Netherlands), 162, 135 - 139, English, International magazine

  Scientific journal


• Descending necrotizing mediastinitis and the proposal of a new classification.

  Kenji Sugio, Tatsuro Okamoto, Yoshimasa Maniwa, Yasushi Toh, Morihito Okada, Taku Yamashita, Shogo Shinohara, Ichiro Yoshino, Masayuki Chida, Hiroyuki Kuwano, Akihiro Shiotani

  OBJECTIVE: We aimed to clarify the clinical features and surgical outcomes of descending necrotizing mediastinitis (DNM) to provide a guide for its surgical treatment, focusing on the type of extension and the deployed procedures. METHODS: As a joint study of the Japan Broncho-esophagological Society and the Japanese Association for Chest Surgery (JBES1703/JACS1806 study), the clinical data of consecutive patients with DNM who underwent surgical drainage between 2012 and 2016 were collected from 131 participating institutions. The infection limited to the area superior to the carina level was defined as type I; while spreading to the lower mediastinum (LM) as type II. The LM infection limited to the anterior LM, that spread to both the anterior and posterior LM and that limited the posterior LM (type IIC) were further categorized as type IIA, IIB, and IIC, respectively. RESULTS: A total of 225 patients were ultimately eligible. One hundred patients (44.4%) were categorized as type I, whereas 125 patients were type II (56.6%); The number of type IIA, IIB, and IIC cases was 20 (16%), 62 (49.6%) and 43 (34.4%), respectively. Patients with type I and IIC infections more commonly underwent cervical drainage than patients with type IIA and IIB infections (34.3% and 13.4%, respectively). A total of 8 patients died within 30 days (3.6%, type I/II: 1/7). The 5-year overall survival rate was 68.6%. Type II infection was associated with the 90-day mortality (odds ratio, 5.18; P = .045). CONCLUSIONS: This study demonstrated a previously unclassified group of lower mediastinal extent that is localized within the posterior mediastinum (type IIC). We proposed a new DNM classification including type IIC mediastinitis.

  Dec. 2021, JTCVS open, 8, 633 - 647, English, International magazine

  Scientific journal


• The Gut Microbiome as a Promising Biomarker of Cancer Progression Among Female Never-smokers With Lung Adenocarcinoma

  Takehiro Otoshi, Tatsuya Nagano, Jonguk Park, Koji Hosomi, Tomoya Yamashita, Motoko Tachihara, Tokiko Tabata, Reina Sekiya, Yugo Tanaka, Kazuyuki Kobayashi, Kenji Mizuguchi, Tomoo Itoh, Yoshimasa Maniwa, Jun Kunisawa, Yoshihiro Nishimura

  Background: The gut microbiome plays an important role in the immune system and has attracted attention as a biomarker of various diseases, including cancer. As such, we examined the relationship between the gut microbiome and lung cancer progression. In addition, we assessed the correlation between the gut microbiome and epidermal growth factor receptor (EGFR) mutation status.Methods: Female never-smokers diagnosed with lung adenocarcinoma were consecutively and prospectively enrolled between May 2018 and August 2019. Fecal samples were collected within 1 month before or after diagnosis and before administration of any lung cancer treatment. Principal coordinate analyses were retrospectively performed using Bray-Curtis distance matrices to investigate the effects of clinical variables (age, body mass index, Tumor-Node-Metastasis stage, T category, N category, M category, primary tumor size, performance status, and EGFR mutation status) on the gut microbial community. A correlation analysis was also performed to determine the strength of association between the dominant taxonomy (comprising ≥1% of the relative abundance of bacterial DNA sequences) and clinical variables.Results: A total of 37 patients were enrolled. T category and primary tumor size were significantly correlated with the gut microbial community (p=0.018 and 0.041, respectively). At the genus level, a significant positive correlation was observed between the relative abundance of Faecalibacterium and both T category (correlation coefficient, R=0.51, p=0.0013) and primary tumor size (R=0.37, p=0.024), whereas a significant negative correlation was observed between the relative abundances of Fusicatenibacter and Bacteroides and T category (R=−0.35, p=0.034 and R=−0.32, p=0.05, respectively) and primary tumor size (R=−0.36, p=0.029 and R=−0.41, p=0.012, respectively). EGFR mutation status had no statistically significant effect on the gut microbial community (p=0.11). However, the relative abundances of Bifidobacterium and Faecalibacterium were significantly higher in EGFR mutation–negative patients than EGFR mutation–positive patients (p=0.012 and 0.041), whereas the relative abundance of Blautia was significantly lower in EGFR mutation–negative patients (p=0.036).Conclusions: This is the first study identifying the gut microbiome as a promising biomarker of lung cancer progression. Further elucidation of the role of the gut microbiome in lung cancer progression could facilitate development of new treatments for lung cancer.

  Research Square Platform LLC, May 2021, Anticancer research, 42(3) (3), 1589 - 1598, English, International magazine

  Scientific journal


• 胸部CT・胸腔鏡で所見の乏しい中皮腫の病態、治療および予後 両側胸膜生検が行われ、片側で早期中皮腫が同定できた1例

  神保 直江, 吉田 美帆, 塚本 龍子, 南 和宏, 田中 雄悟, 眞庭 謙昌, 河原 邦光, 田中 伴典, 伊藤 智雄

  (公社)日本臨床細胞学会, May 2021, 日本臨床細胞学会雑誌, 60(Suppl.1) (Suppl.1), 138 - 138, Japanese


• Paraneoplastic Neuromyelitis Optica Spectrum Disorder Associated with Atypical Thymic Carcinoid: A Case Report.

  Suguru Mitsui, Yugo Tanaka, Kenji Kimura, Naoe Jimbo, Norio Chihara, Yoshimasa Maniwa

  Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune inflammatory disease, occasionally accompanied by malignant tumors. Immunosuppressive therapy is the mainstay treatment for idiopathic NMOSD; no guidelines have been published for paraneoplastic NMOSD because it is rarely reported in the literature. We report a rare case of a 67-year-old man with paraneoplastic NMOSD associated with thymic carcinoid whose cells expressed aquaporin-4 antibody. After surgical resection, the patient's symptoms improved, and serum aquaporin-4 autoantibody turned negative. We believe that radiographic examination for mediastinal tumors in patients with NMOSD is necessary because thymic epithelial tumors could have a role in the pathogenesis of paraneoplastic NMOSD. After mediastinal tumor has been detected, they should be surgically resected to improve neurological symptoms.

  Apr. 2021, Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia, 28(5) (5), 362 - 365, English, Domestic magazine

  Scientific journal


• A case of type AB thymoma with atypical histological features: Is atypical type AB thymoma an acceptable variant of thymoma?

  Naoe Jimbo, Hisashi Tateyama, Masato Komatsu, Takefumi Doi, Yugo Tanaka, Yoshimasa Maniwa, Tomoo Itoh

  Apr. 2021, Pathology international, 71(4) (4), 272 - 274, English, International magazine


• Preoperative nivolumab to evaluate pathological response in patients with stage I non-small cell lung cancer: a study protocol of phase II trial (POTENTIAL).

  Atsushi Kagimoto, Yasuhiro Tsutani, Takahiro Mimae, Yoshihiro Miyata, Norihiko Ikeda, Hiroyuki Ito, Yoshimasa Maniwa, Kenji Suzuki, Masahiro Tsuboi, Kenichi Yoshimura, Seiji Umemoto, Morihito Okada

  INTRODUCTION: Recently, inhibition of programmed cell death 1 or its ligand has shown therapeutic effects on non-small cell lung cancer (NSCLC). However, the effectiveness of preoperative nivolumab monotherapy for stage I NSCLC remains unknown. The present study aimed to investigate the pathological response of preoperative treatment with nivolumab for clinically node negative but having a high risk of NSCLC recurrence. METHODS AND ANALYSIS: The Preoperative Nivolumab (Opdivo) to evaluate pathologic response in patients with stage I non-small cell lung cancer: a phase 2 trial (POTENTIAL) study is a multicentre phase II trial investigating efficacy of preoperative nivolumab for clinical stage I patients at high risk of recurrence. This study includes histologically or cytologically confirmed NSCLC patients with clinical N0 who were found on preoperative high-resolution CT to have a pure solid tumour without a ground-glass opacity component (clinical T1b, T1c or T2a) or a solid component measuring 2-4 cm in size (clinical T1c or T2a). Patients with epidermal growth factor receptor (EGFR) mutation (deletion of exon 19 or point mutation on exon21, L858R), anaplastic lymphoma kinase (ALK) translocation or c-ros oncogene 1 (ROS-1) translocation are excluded from this study. Nivolumab (240 mg/body) is administrated intravenously as preoperative therapy every 2 weeks for three cycles. Afterward, lobectomy and mediastinal lymph node dissection (ND 2a-1 or ND 2a-2) are performed. The primary endpoint is a pathological complete response in the resected specimens. The secondary endpoints are safety, response rates and major pathological response. The planed sample size is 50 patients. Patients have been enrolled since April 2019. ETHICS AND DISSEMINATION: This trial was approved by the Institutional Review Board of Hiroshima University Hospital and other participating institutions. This trial will help examine the efficacy of preoperative nivolumab therapy for clinical stage I NSCLC. TRIAL REGISTRATION NUMBER: jRCT2061180016.

  Mar. 2021, BMJ open, 11(3) (3), e043234, English, International magazine

  Scientific journal


• 術後補助化学療法施行肺腺癌におけるOCT3の発現と患者予後との関連

  道本 貴則, 井筒 雅大, 大崎 博之, 鴨志田 伸吾, 永野 達也, 桐生 辰徳, 西村 義博, 眞庭 謙昌, 神保 直江, 伊藤 智雄

  (一社)日本病理学会, Mar. 2021, 日本病理学会会誌, 110(1) (1), 284 - 284, Japanese


• Fibrous bands associated with higher Masaoka stage and poor recurrence-free survival in patients with thymoma.

  Kazuhiro Minami, Naoe Jimbo, Yugo Tanaka, Takahiro Uchida, Takeshi Okamoto, Nahoko Shimizu, Takefumi Doi, Daisuke Hokka, Tomoo Itoh, Yoshimasa Maniwa

  BACKGROUND: Fibrous bands (FBs) are one of the histological features in tumors which can be confirmed by hematoxylin and eosin (H&E)-stained slides. FBs have been reported to correlate with malignancy in various tumors. This study aimed to investigate whether the presence of FBs is associated with malignancy in thymoma. METHODS: A total of 123 consecutive patients with thymoma who underwent microscopically complete resections from January 2000 to December 2018 were enrolled into this study. H&E-stained slides of all thymoma patients were re-examined. Study patients were classified into two groups: with FBs (n = 36) and without FBs (n = 87). Clinicopathological characteristics, overall survival (OS), and recurrence-free survival (RFS) were compared between the two groups. Furthermore, multivariate analyses were performed to identify whether the presence of FBs was associated with higher Masaoka stage and poor prognosis in patients with thymoma. RESULTS: The Masaoka stage was found to be higher and recurrence more likely in thymoma patients with FBs than in those without. RFS was significantly poorer in thymoma patients with FBs than in those without, although no significant difference was observed in OS between them. The presence of FBs was significantly associated with higher Masaoka stage in the multivariate analysis using logistic regression. Additionally, the presence of FBs was an independent prognostic factor for poor RFS in multivariate analysis using Cox's proportional hazards model. CONCLUSIONS: The presence of FBs in patients with thymoma was associated with higher Masaoka stage, higher recurrence rate, and poorer RFS. KEY POINTS: SIGNIFICANT FINDINGS OF THE STUDY: Fibrous bands (FBs) are bands of fibrosis dividing tumors into different-sized irregular islands. The presence of FBs is associated with higher Masaoka stage and poor recurrence-free survival in patients with thymoma. WHAT THIS STUDY ADDS: The presence of fibrous bands might be associated with the malignant behavior of thymoma. Confirming the presence or absence of FBs may result in personalized medication for patients with thymoma.

  Feb. 2021, Thoracic cancer, 12(3) (3), 349 - 356, English, International magazine

  Scientific journal


• Successful treatment of refractory empyema using dual sheet covering

  Takahiro Uchida, Yugo Tanaka, Sanae Kuroda, Daisuke Hokka, Yoshimasa Maniwa

  SAGE Publications Inc., 2021, Asian Cardiovascular and Thoracic Annals, 30(3) (3), 342 - 344, English, International magazine

  Scientific journal


• 【胸部の最新画像情報2021】アミロイド沈着により著明な石灰化を呈した胸腺リンパ腫の1例

  田原 潤子, 田中 千賀, 松尾 秀俊, 神田 知紀, 神保 直江, 伊藤 智雄, 田中 雄悟, 眞庭 謙昌

  金原出版(株), Jan. 2021, 臨床放射線, 66(1) (1), 59 - 64, Japanese


• High expression level of serpin peptidase inhibitor clade E member 2 is associated with poor prognosis in lung adenocarcinoma.

  Ryota Dokuni, Tatsuya Nagano, Naoe Jimbo, Hiroki Sato, Tatsunori Kiriu, Yuichiro Yasuda, Masatsugu Yamamoto, Motoko Tachihara, Kazuyuki Kobayashi, Yoshimasa Maniwa, Yoshihiro Nishimura

  BACKGROUND: Recent studies have revealed that serpin peptidase inhibitor clade E member 2 (SERPINE2) is associated with tumorigenesis. However, SERPINE2 expression and its role in lung adenocarcinomas are still unknown. METHODS: The expression levels of SERPINE2 in 74 consecutively resected lung adenocarcinomas were analyzed by using immunostaining. Inhibition of SERPINE2 expression by small interfering RNA (siRNA) was detected by quantitative PCR. Cell number assays and cell apoptosis assays were performed to clarify the cell-autonomous function of SERPINE2 in A549 and PC9 lung cancer cells. RESULTS: The overall survival of patients with high SERPINE2 expression was significantly worse than that of patients with low SERPINE2 expression (P = 0.0172). Multivariate analysis revealed that SERPINE2 expression was an independent factor associated with poor prognosis (P = 0.03237). The interference of SERPINE2 decreased cell number and increased apoptosis in A549 and PC9 cells CONCLUSION: These results suggest that SERPINE2 can be used as a novel prognostic marker of lung adenocarcinoma.

  Dec. 2020, Respiratory research, 21(1) (1), 331 - 331, English, International magazine

  Scientific journal


• Bex1 significantly contributes to the proliferation and invasiveness of malignant tumor cells.

  Takefumi Doi, Hiroyuki Ogawa, Yugo Tanaka, Yoshitake Hayashi, Yoshimasa Maniwa

  Invasion has a significant role in cancer progression, including expansion to surrounding tissue and metastasis. Previously, we assessed the invasive ability of cancer cells using an easy-to-prepare double-layered collagen gel hemisphere (DL-CGH) method by which cancer cell invasion can be easily visualized. The present study examined multiple lung adenocarcinoma and malignant pleural mesothelioma (MPM) cell lines using the DL-CGH method and identified inherently invasive cell lines. Next, by comparing gene expression between invasive and non-invasive cells by cDNA microarray, the potential candidate gene brain-expressed x-linked protein 1 (Bex1) was identified to be involved in cancer invasion, as it was highly expressed in the invasive cell lines. Downregulation of Bex1 suppressed the invasion and proliferation of the invasive tumor cell lines. The findings of the present study suggested that Bex1 may promote metastasis in vivo and could be a potential oncogene and molecular therapeutic target in lung adenocarcinoma and MPM.

  Dec. 2020, Oncology letters, 20(6) (6), 362 - 362, English, International magazine

  Scientific journal


• 摘出肺の鬱血をきたした椎体合併肺葉切除術の1例

  黒田 紗菜恵, 田中 雄悟, 三浦 賢仁, 土井 健史, 法華 大助, 眞庭 謙昌

  (NPO)日本呼吸器外科学会, Nov. 2020, 日本呼吸器外科学会雑誌, 34(7) (7), 682 - 687, Japanese


• 喫煙歴のない肺腺癌女性患者における腸内細菌叢と腫瘍の進展・EGFR遺伝子変異との関連について

  大歳 丈博, 永野 達也, 立原 素子, 古川 皓一, 桐生 辰徳, 関谷 怜奈, 桂田 雅大, 桂田 直子, 山本 正嗣, 田中 雄悟, 小林 和幸, 眞庭 謙昌, 西村 善博

  (NPO)日本肺癌学会, Oct. 2020, 肺癌, 60(6) (6), 644 - 644, Japanese


• Phase II study of adjuvant chemotherapy with pemetrexed and cisplatin with a short hydration method for completely resected nonsquamous non-small cell lung cancer.

  Motoko Tachihara, Ryota Dokuni, Keiko Okuno, Shuntaro Tokunaga, Kyosuke Nakata, Naoko Katsurada, Masatsugu Yamamoto, Tatsuya Nagano, Kazuyuki Kobayashi, Yugo Tanaka, Yasuhiro Funada, Yoshimasa Maniwa, Yoshihiro Nishimura

  BACKGROUND: Cisplatin (CDDP) and vinorelbine as an adjuvant chemotherapy improve the overall survival of patients with completely resected non-small cell lung cancer (NSCLC). However, the treatment completion rate is low due to severe adverse events (AEs). Pemetrexed (PEM) has been used in advanced NSCLC due to its high safety and efficacy. Additionally, the safety of a short hydration method for CDDP administration has been previously reported. Here, we investigated the feasibility of CDDP plus PEM with a short hydration method as adjuvant chemotherapy. METHODS: A total of 21 completely resected nonsquamous NSCLC patients with pathological stage IIA to IIIA disease were enrolled into the study. Adjuvant chemotherapy consisted of four cycles of CDDP (75 mg/m2 ) plus PEM (500 mg/m2 ) every three weeks with a short hydration method. The primary endpoint was the treatment completion rate, and the secondary endpoints included toxicity, the two-year relapse-free survival (RFS) rate, and the outpatient treatment rate. RESULTS: A total of 21 patients (median age: 66 years; 12 males) were enrolled in two centers. All cases were adenocarcinoma with PS0 (71.4%) or PS1 (28.6%). A total of 81.0% of the patients received four cycles of therapy as scheduled and the primary endpoint was met. The rate of outpatient chemotherapy completion after the second cycle was 90.5%. The grade 3 or higher toxicities were anorexia (n = 2) and pulmonary thromboembolism (n = 1). No grade 3/4 hematological toxicities or creatinine level elevations were observed. The two-year RFS rate was 57.3%. CONCLUSIONS: CDDP and PEM with a short hydration is well tolerated in the outpatient setting with limited toxicity. KEY POINTS: SIGNIFICANT FINDINGS OF THE STUDY: CDDP plus PEM adjuvant therapy with a short hydration method is well tolerated in the outpatient setting with limited toxicity. WHAT THIS STUDY ADDS: CDDP plus PEM with a short hydration method has the potential to be one of the options of adjuvant therapy in the future.

  Sep. 2020, Thoracic cancer, 11(9) (9), 2536 - 2541, English, International magazine

  Scientific journal


• Insulinoma-associated protein 1 is a prognostic biomarker in pulmonary high-grade neuroendocrine carcinoma.

  Kazuhiro Minami, Naoe Jimbo, Yugo Tanaka, Hiroyuki Ogawa, Daisuke Hokka, Wataru Nishio, Masahiro Yoshimura, Tomoo Itoh, Yoshimasa Maniwa

  BACKGROUNDS AND OBJECTIVES: Recent studies have suggested that insulinoma-associated protein 1 (INSM1) is a useful marker for pathological diagnosis of pulmonary neuroendocrine tumors. In the present study, we investigated the association between INSM1 expression and prognosis in patients with pulmonary high-grade neuroendocrine carcinomas (HGNEC) and assessed the usefulness of INSM1 as a prognostic biomarker in these patients. METHODS: Seventy-five consecutive patients with HGNEC who underwent complete surgical resections from January 2000 to December 2018 were enrolled in this study. We classified these patients into two groups: the INSM1-positive group (n = 59) and INSM1-negative group (n = 16). We compared the clinicopathological characteristics, overall survival (OS), and recurrence-free survival (RFS) between the groups. In addition, we performed univariate and multivariate analyses to identify the prognostic factors associated with postoperative survival. RESULTS: Significant differences in tumor diameter and vascular invasion between the groups were found. OS and RFS were significantly poorer in the INSM1-positive group than in the INSM1-negative group. Univariate and multivariate analyses revealed that INSM1 expression was the strongest predictor of poor prognosis for OS and RFS. CONCLUSIONS: INSM1 expression had the greatest influence on the prognosis in patients with HGNEC and may be a prognostic biomarker in these patients.

  Apr. 2020, Journal of surgical oncology, 122(2) (2), 243 - 253, English, International magazine

  Scientific journal


• Malignant pleural mesothelioma showing intrapulmonary lepidic spread.

  Naoe Jimbo, Kunimitsu Kawahara, Ryuko Tsukamoto, Kazuhiro Minami, Yugo Tanaka, Yoshimasa Maniwa, Tomoo Itoh

  Apr. 2020, Pathology international, 70(6) (6), 373 - 375, English, International magazine

  [Refereed]


• 外科的治療によりコントロール可能であった大細胞神経内分泌癌の副腎単発転移の1例

  佐藤 宏紀, 立原 素子, 桐生 辰徳, 梅澤 佳乃子, 桂田 直子, 永野 達也, 山本 正嗣, 小林 和幸, 西村 善博, 田中 雄悟, 眞庭 謙昌

  (NPO)日本肺癌学会, Apr. 2020, 肺癌, 60(2) (2), 153 - 154, Japanese


• 免疫チェックポイント阻害薬での治療中に増大した異時性多発肺癌の1例

  高田 尚哉, 立原 素子, 梅澤 佳乃子, 桂田 直子, 永野 達也, 山本 正嗣, 西村 善博, 大橋 千裕, 田中 雄悟, 眞庭 謙昌, 田中 伴典

  (NPO)日本肺癌学会, Apr. 2020, 肺癌, 60(2) (2), 154 - 155, Japanese


• Oxidized regenerated cellulose for a clear thoracoscopic view: a single-centre randomized trial.

  Nahoko Shimizu, Yugo Tanaka, Sanae Kuroda, Hayate Nakamura, Gaku Matsumoto, Suguru Mitsui, Shuto Sakai, Kazuhiro Minami, Takefumi Doi, Daisuke Hokka, Yoshimasa Maniwa

  OBJECTIVES: During video-assisted thoracoscopic surgery (VATS), blood oozing from the surface of the access port wound can hamper the surgical view. Although this oozing is difficult to prevent, it can be decreased by placing a wound edge protector with oxidized regenerated cellulose (ORC) on the surface of the access port wound, thereby improving the surgical outcomes and safety of VATS. METHODS: We conducted a prospective, single-centre, open-label, randomized clinical trial to evaluate the operative outcomes of VATS when using the ORC (ORC group) compared with operative outcomes without using the ORC (non-ORC group). The primary end point was interruption of the operation as a result of blood oozing from the surface of the access port wound. The secondary end points were the other intraoperative and postoperative outcomes. RESULTS: A total of 108 patients were divided into the ORC group (n = 54) and the non-ORC group (n = 54). Compared with the non-ORC group, the ORC group had fewer patients with an interruption in the operation (11.1% vs 51.8%; P < 0.001), less need for wound haemostasis of the access ports during wound closure (44.4% vs 72.2%; P = 0.003), similar rates of postoperative deaths and complications and a tendency for shorter operation times (149.3 vs 168.8 min, respectively; P = 0.083). CONCLUSION: The use of an ORC sheet around a wound edge protector for haemostasis can ensure a clear view during VATS. CLINICAL TRIAL REGISTRATION NUMBER: UMIN000031112.

  Mar. 2020, Interactive cardiovascular and thoracic surgery, 30(3) (3), 346 - 352, English, International magazine

  Scientific journal


• 術後補助化学療法施行肺腺癌におけるATOX1の発現と患者予後との関連

  小松 由季, 大崎 博之, 鴨志田 伸吾, 永野 達也, 桐生 辰徳, 西村 善博, 眞庭 謙昌, 神保 直江, 伊藤 智雄

  (一社)日本病理学会, Mar. 2020, 日本病理学会会誌, 109(1) (1), 410 - 410, Japanese


• Caspase Recruitment Domain-Containing Protein 9 Expression is a Novel Prognostic Factor for Lung Adenocarcinoma.

  Nanako Miwa, Tatsuya Nagano, Naoe Jimbo, Ryota Dokuni, Tatsunori Kiriu, Chihiro Mimura, Yuichiro Yasuda, Masahiro Katsurada, Masatsugu Yamamoto, Motoko Tachihara, Yugo Tanaka, Kazuyuki Kobayashi, Tomoo Itoh, Yoshimasa Maniwa, Yoshihiro Nishimura

  Purpose: Caspase recruitment domain-containing protein 9 (CARD9) is expressed at high levels in bone marrow cells and has a crucial role in innate immunity. Current studies indicate that CARD9 also plays a key role in tumor progression, but there are few reports on the role of CARD9 in lung cancer. The aim of this study was to clarify the role of CARD9 in lung adenocarcinoma. Patients and Methods: Lung adenocarcinoma tumor samples from 74 patients who underwent complete resection at Kobe University Hospital from January 2014 to December 2014 were analyzed by immunohistochemistry. The role of CARD9 in cancer cells was analyzed using lung cancer cell lines treated with CARD9 siRNA. Results: High expression of CARD9 was observed in 32.4% of tumors, and compared to low expression of CARD9, high expression was associated with poorer overall survival (P = 0.0365). Univariate and multivariate analyses showed that high expression of CARD9 was an independent prognostic factor. Knockdown of CARD9 in lung adenocarcinoma cells inhibited proliferation but did not increase apoptosis. In addition, CARD9 activated the NF-κB pathway in a lung adenocarcinoma cell line. Conclusion: CARD9 was shown to be an independent prognostic factor of poor outcome for lung cancer and may represent a molecular target for treatment.

  2020, OncoTargets and therapy, 13, 9005 - 9013, English, International magazine

  Scientific journal


• 2年間以上形態学的変化のなかった肺腫瘤が原因であった異所性ACTH症候群の一例

  辻本 泰貴, 中村 友昭, 山本 直希, 高吉 倫史, 山本 雅昭, 福岡 秀規, 佐藤 伊都子, 大橋 千裕, 田中 雄悟, 眞庭 謙昌, 稲葉 礼奈, 神保 直江, 小川 渉, 高橋 裕, 千原 和夫

  (一社)日本内分泌学会, Jan. 2020, 日本内分泌学会雑誌, 95(3) (3), 1142 - 1142, Japanese


• 肺癌との鑑別に苦慮した肺ヒストプラズマ症の1切除例

  光井 卓, 清水 奈保子, 田中 雄悟, 大路 剛, 亀井 克彦, 眞庭 謙昌

  (NPO)日本呼吸器外科学会, Jan. 2020, 日本呼吸器外科学会雑誌, 34(1) (1), 57 - 61, Japanese

  [Refereed]


• Feasibility Study of Adjuvant Chemotherapy with Carboplatin and Nab-Paclitaxel for Completely Resected NSCLC.

  Naoko Katsurada, Motoko Tachihara, Yukihisa Hatakeyama, Kiyoko Koyama, Masako Yumura, Tatsunori Kiriu, Ryota Dokuni, Daisuke Hazama, Shuntaro Tokunaga, Daisuke Tamura, Kyosuke Nakata, Masatsugu Yamamoto, Hiroshi Kamiryo, Kazuyuki Kobayashi, Yugo Tanaka, Yoshimasa Maniwa, Yoshihiro Nishimura

  Purpose: Adjuvant chemotherapy with cisplatin (CDDP) plus vinorelbine is the standard regimen for the treatment of non-small cell lung cancer (NSCLC). However, CDDP elicits severe toxic effects, including emesis, neurotoxicity, and renal damage; carboplatin (CBDCA) may be a feasible alternative for CDDP-unfit patients. CBDCA plus paclitaxel (PTX) adjuvant chemotherapy showed a survival benefit for patients with stage IB tumors >4 cm in size, while CBDCA plus nanoparticle albumin-bound (nab)-PTX showed greater efficacy and lower neurotoxicity than CBDCA plus PTX in advanced NSCLC. Here, we investigated the feasibility of using CBDCA plus nab-PTX as adjuvant chemotherapy for NSCLC. Patients and Methods: Patients with completely resected stage II or III NSCLC, with an Eastern Cooperative Oncology Group performance status of 0-1 and adequate kidney function, received four cycles of postoperative adjuvant chemotherapy with CBDCA (AUC=5 mg/mL/min, on day 1) and nab-PTX (100 mg/m2, on days 1, 8, and 15) administered every 4 weeks within 8 weeks after surgery. The study was designed as a prospective, single-center, Phase II study. The primary endpoint was the completion rate of chemotherapy; secondary endpoints were two-year relapse-free survival (RFS) and safety. The expected completion rate was 80%, with a 50% lower limit. Results: Of 21 enrolled patients, 18 (85.7%) were CDDP-unfit owing to age (≥75 years old [n=11, 52.4%]) or mild renal impairment (n=7, 33.3%). Nineteen of the 21 enrolled patients were assigned to the intervention. The most common grade 3 or 4 adverse events were neutropenia (n=15, 78.9%) and anemia (n=3, 15.8%). The completion rate for the four cycles was 63.2% (95% CI, 38.4-83.7). Two-year RFS was 56.8% (95% CI, 29.7-76.9). Conclusion: The completion rate for CBDCA plus nab-PTX as adjuvant chemotherapy for CDDP-unfit NSCLC patients did not reach treatment feasibility. Further dose modifications may be required in future studies.

  2020, Cancer management and research, 12, 777 - 782, English, International magazine

  [Refereed]

  Scientific journal


• Psf3 as a possible biomarker of postoperative chemotherapy for patients with early pulmonary adenocarcinoma.

  Kenji Kimura, Yugo Tanaka, Shunsuke Tauchi, Yoshitaka Kitamura, Wataru Nishio, Yasuhiro Sakai, Yoshitake Hayashi, Masahiro Yoshimura, Yoshimasa Maniwa

  BACKGROUND: Partner of Sld five 3 (Psf3) is a member of the heterotetrameric complex that consists of SLD5, Psf1, Psf2, and Psf3. We have shown in previous studies that high Psf3 expression was a poor prognostic marker for pulmonary adenocarcinoma. Here, we statistically evaluated the relationship between clinicopathologic factors and Psf3 expression in stage I pulmonary adenocarcinoma. METHODS: A total of 583 patients who had undergone complete resection of stage I pulmonary adenocarcinoma from January 2002 to December 2009 were included in the study. Tissue microarrays were performed, and the resected tumors were divided into groups according to Psf3 expression. RESULTS: Of 583 patients, high expression of Psf3 was observed in 211 (36.2%) and low expression of Psf3 observed in 372 (63.8%) patients. Among stage I patients, the five-year survival rate was 76.7% in the Psf3 high expression group and 90.9% in the Psf3 low expression group (P < 0.0001). On multivariate analysis, Psf3 was found to be the independent prognostic factor. Among stage I patients in the Psf3 high expression group, a significantly greater five-year survival rate was observed in patients who received postoperative chemotherapy with tegafur-uracil than in those who underwent surgery alone (P < 0.0001). In contrast, among stage I patients in the Psf3 low expression group, no difference was found in the five-year survival, regardless of the presence or absence of tegafur-uracil (P = 0.873). CONCLUSION: The Psf3 expression was an independent prognostic factor and could be a biomarker of adjuvant tegafur-uracil for stage I pulmonary adenocarcinoma. KEY POINTS: Significant findings of the study: The Psf3 expression could be a biomarker of adjuvant tegafur-uracil administration for stage I pulmonary adenocarcinoma. WHAT THIS STUDY ADDS: Appropriate patients of adjuvant chemotherapy for stage I pulmonary adenocarcinoma using Psf3 expression could be selected.

  Dec. 2019, Thoracic cancer, 10(12) (12), 2300 - 2307, English, International magazine

  Scientific journal


• Mediastinal Shift Due to the Rapidly Expanded Giant Bulla Probably Caused by the Lung Cancer

  Suguru Mitsui, Nahoko Shimizu, Yugo Tanaka, Hayate Nakamura, Sanae Kuroda, Gaku Matsumoto, Shuto Sakai, Kenji Kimura, Takefumi Doi, Hiroyuki Ogawa, Daisuke Hokka, Yoshimasa Maniwa

  NLM (Medline), Dec. 2019, Kyobu geka. The Japanese journal of thoracic surgery, 72(13) (13), 1068 - 1071, Japanese, Domestic magazine

  Scientific journal


• 急速に増大し縦隔偏位をきたした肺癌合併巨大肺嚢胞

  光井 卓, 清水 奈保子, 田中 雄悟, 中村 速, 黒田 紗菜恵, 松本 学, 酒井 秀都, 木村 賢司, 土井 健史, 小川 裕行, 法華 大助, 眞庭 謙昌

  (株)南江堂, Dec. 2019, 胸部外科, 72(13) (13), 1068 - 1071, Japanese


• Surgery and Proton Beam Therapy for Mediastinal Extraskeletal Osteosarcoma.

  Nahoko Shimizu, Yugo Tanaka, Yusuke Demizu, Tomoaki Okimoto, Yoshimasa Maniwa

  Extraskeletal osteosarcoma (ESOS) arising from the mediastinum is a rare malignant tumor and associated with a poor prognosis. We present the case of a 73-year-old man with a hoarseness. Imaging studies revealed a large calcified tumor of the median mediastinum. Surgery was performed, but complete resection was impossible and approximately two thirds of the tumor was excised. The tumor was diagnosed pathologically as ESOS. Proton beam therapy has been performed on the remaining lesion, and the patient is alive without tumor regrowth after 29 months. This case report documents a mediastinum ESOS successfully treated successfully with surgery and postoperative proton therapy.

  Nov. 2019, The Annals of thoracic surgery, 108(5) (5), e289-e291, English, International magazine

  Scientific journal


• 前縦隔に広範囲に石灰化を認めたlow-grade B-cell lymphomaの1例

  井澤 良介, 南 和宏, 清水 奈保子, 土井 健史, 神保 直江, 田中 雄悟, 眞庭 謙昌

  (NPO)日本肺癌学会, Nov. 2019, 肺癌, 59(6) (6), 882 - 882, Japanese


• 前縦隔に広範囲に石灰化を認めたlow-grade B-cell lymphomaの1例

  井澤 良介, 南 和宏, 清水 奈保子, 土井 健史, 神保 直江, 田中 雄悟, 眞庭 謙昌

  (NPO)日本肺癌学会, Nov. 2019, 肺癌, 59(6) (6), 882 - 882, Japanese

  [Refereed]


• 関節リウマチに続発した多房性胸腺嚢胞合併胸腺癌の1切除例

  光井 卓, 田中 雄悟, 岡本 武士, 清水 奈保子, 土井 健史, 法華 大助, 神保 直江, 真庭 謙昌

  (NPO)日本肺癌学会, Nov. 2019, 肺癌, 59(6) (6), 884 - 884, Japanese

  [Refereed]


• [Chest Wall Resection and Reconstruction].

  Nahoko Shimizu, Yoshimasa Maniwa

  Lung cancer invasion of the chest wall is considered to occur in approximately 5% of all patients who had undergone lung cancer resection. Surgical resection is recognized as a standard treatment, and surgical treatment plays a major role because survival is highly dependent on the completeness of the resection. On the other hand, prognosis is still poor in cases with mediastinal lymph node involvement, and the indications for surgery remain controversial in such cases, with increasing number of reported perioperative chemoradiotherapy cases. In addition, the use of minimally invasive surgery combined with thoracoscopy has become widespread in recent years, and indications are being considered for chest wall resection cases. In this paper, we review the results of operation for lung cancer with chest wall invasion other than those for superior sulcus tumors and discuss the role of surgical treatment and surgical resection and reconstruction techniques.

  Sep. 2019, Kyobu geka. The Japanese journal of thoracic surgery, 72(10) (10), 845 - 849, Japanese, Domestic magazine

  Scientific journal


• Diaphragmatic plication for iatrogenic respiratory insufficiency after cardiothoracic surgery.

  Takahiro Uchida, Yugo Tanaka, Nahoko Shimizu, Sanae Kuroda, Takefumi Doi, Daisuke Hokka, Yutaka Okita, Yoshimasa Maniwa

  Background: The efficacy of diaphragmatic plication (DP) has been proven in many studies. However, there are few reports on DP for patients with severe respiratory conditions requiring mechanical ventilation. The study aim was to demonstrate the efficacy of DP for patients with severe respiratory insufficiency after cardiothoracic surgeries. Methods: We retrospectively reviewed 10 patients who underwent DP for severe respiratory insufficiency due to postoperative diaphragmatic paralysis; eight of them required mechanical ventilation, and two needed high-flow oxygen therapy prior to DP. The symptoms, lung function, and elevation of the diaphragm were assessed before and after DP. Results: All patients were successfully withdrawn from mechanical ventilation after DP and discharged without the need for oxygen therapy. The mean perioperative Medical Research Council (MRC) dyspnea scale (ATS/ERS 2004) score improved in 30 days (from 4 to 1.8) and in 90 days (from 4 to 0.6) after DP. Lung dynamic compliance was also ameliorated (mean improvement: 41.9 to 60.7 mL/cmH2O). Radiography revealed improved elevation of the diaphragm (mean improvement of 1.8 intercostal spaces, range, 1-2). Mean hospital stay after DP was 65.5 days (range, 25-187 days). One patient who underwent DP with endostapler-only suturing required re-operation because of staple line ruptures. Conclusions: DP was found to be an effective form of treatment for patients with severe respiratory insufficiency after cardiothoracic surgery.

  Sep. 2019, Journal of thoracic disease, 11(9) (9), 3704 - 3711, English, International magazine

  Scientific journal


• アミロイド沈着により著明な石灰化を呈した前縦隔リンパ腫の1例

  松尾 秀俊, 岸田 雄治, 神田 知紀, 神保 直江, 伊藤 智雄, 田中 雄悟, 眞庭 謙昌, 村上 卓道

  (公社)日本医学放射線学会, Sep. 2019, 日本医学放射線学会秋季臨床大会抄録集, 55回, S550 - S550, Japanese

  [Refereed]


• Tumor-induced Hypophosphatemic Osteomalacia Caused by a Chest Wall Tumor

  Yasuo Kin, Hiroyuki Ogawa, Gaku Matsumoto, Suguru Mitsui, Takanori Matsumoto, Yuki Nishioka, Syuto Sakai, Kenji Kimura, Nahoko Shimizu, Daisuke Hokka, Yugo Tanaka, Yoshimasa Maniwa

  NLM (Medline), Aug. 2019, Kyobu geka. The Japanese journal of thoracic surgery, 72(8) (8), 570 - 573, Japanese, Domestic magazine

  Scientific journal


• 胸壁発生腫瘍による腫瘍性低リン血症性骨軟化症

  金 泰雄, 小川 裕行, 松本 学, 光井 卓, 松本 高典, 西岡 祐希, 酒井 秀都, 木村 賢司, 清水 奈保子, 法華 大助, 田中 雄悟, 眞庭 謙昌

  (株)南江堂, Aug. 2019, 胸部外科, 72(8) (8), 570 - 573, Japanese


• 再発時に脱分化が疑われたmalignant solitary fibrous tumorの1例

  南 和宏, 田中 雄悟, 中村 速, 黒田 紗菜恵, 松本 学, 光井 卓, 酒井 秀都, 木村 賢司, 岡本 武士, 清水 奈保子, 土井 健史, 法華 大助, 眞庭 謙昌, 神保 直江, 酒井 康裕

  (NPO)日本肺癌学会, Aug. 2019, 肺癌, 59(4) (4), 426 - 426, Japanese


• 再発時に脱分化が疑われたmalignant solitary fibrous tumorの1例

  南 和宏, 田中 雄悟, 中村 速, 黒田 紗菜恵, 松本 学, 光井 卓, 酒井 秀都, 木村 賢司, 岡本 武士, 清水 奈保子, 土井 健史, 法華 大助, 眞庭 謙昌, 神保 直江, 酒井 康裕

  (NPO)日本肺癌学会, Aug. 2019, 肺癌, 59(4) (4), 426 - 426, Japanese

  [Refereed]


• 体外循環が必要であったleft sleeve pneumonectomyの1手術例

  黒田 紗菜恵, 清水 奈保子, 田中 雄悟, 中村 速, 法華 大助, 眞庭 謙昌

  (NPO)日本呼吸器外科学会, Jul. 2019, 日本呼吸器外科学会雑誌, 33(5) (5), 532 - 537, Japanese


• 胸腔ドレナージ開始後に顕在化した外傷性横隔膜ヘルニアの1例

  酒井 秀都, 田中 雄悟, 中村 速, 黒田 紗菜恵, 法華 大助, 眞庭 謙昌

  (NPO)日本呼吸器外科学会, Jul. 2019, 日本呼吸器外科学会雑誌, 33(5) (5), 573 - 577, Japanese


• Establishment of a safe thoracoscopic surgery.

  Nahoko Shimizu, Yugo Tanaka, Yoshimasa Maniwa

  May 2019, Journal of thoracic disease, 11(Suppl 9) (Suppl 9), S1430-S1431, English, International magazine

  Scientific journal


• Efficacy of perioperative chemotherapy for pulmonary high-grade neuroendocrine carcinomas: a propensity score matching analysis.

  Hiroyuki Ogawa, Yugo Tanaka, Yoshitaka Kitamura, Nahoko Shimizu, Takefumi Doi, Daisuke Hokka, Shinya Tane, Wataru Nishio, Masahiro Yoshimura, Yoshimasa Maniwa

  Background: Large-cell neuroendocrine carcinoma (LCNEC) and small cell lung cancer (SCLC) are categorized as high-grade neuroendocrine carcinoma (HGNEC). We analyzed the efficacy of perioperative chemotherapy for HGNEC and the prognostic factors. Methods: We retrospectively reviewed the medical records of patients who underwent tumor resection and were diagnosed with HGNEC between January 2001 and December 2014. The overall survival (OS) was estimated by the Kaplan-Meier method. Propensity score matching was performed to compare the OS between the treatment groups. Multivariate analyses using a Cox proportional hazards model were performed to search for prognostic factors for HGNEC. Results: We analyzed 146 HGNEC patients (LCNEC n=92, SCLC n=54) without synchronous multiple cancers, who underwent complete resection. Seventy patients (LCNEC n=31, SCLC n=32) received perioperative chemotherapy and all of them received a platinum-based anticancer drug. Perioperative chemotherapy significantly improved the 5-year OS rates of HGNEC patients (all stages: 74.5% vs. 34.7%, P<0.01, stage I: 88.5% vs. 40.0%, P<0.01). The efficacy of perioperative chemotherapy was similar between LCNEC and SCLC patients [LCNEC all stages: hazard ratio (HR) 0.27, P<0.01, LCNEC stage I: HR 0.27, P=0.01; SCLC all stages: HR 0.38, P=0.02, SCLC stage I: HR 0.34, P=0.06]. The survival benefit of perioperative chemotherapy for HGNEC patients was confirmed by propensity score matching analysis (HR 0.31, P<0.01). The multivariate analysis revealed that perioperative chemotherapy (HR 0.29, P<0.01), sublobar resection (HR 2.11, P=0.04), and lymph node metastasis (HR 3.34, P<0.01) were independently associated with survival. Conclusions: Surgical resection combined with perioperative chemotherapy was considered to be effective even for stage I HGNEC patients. Sublobar resection might increase the risk of death in HGNEC patients.

  Apr. 2019, Journal of thoracic disease, 11(4) (4), 1145 - 1154, English, International magazine

  Scientific journal


• in situ主体の悪性胸膜中皮腫が疑われた1例

  南 和宏, 田中 雄悟, 中村 速, 黒田 紗菜恵, 松本 学, 光井 卓, 酒井 秀都, 木村 賢司, 岡本 武士, 清水 奈保子, 土井 健史, 法華 大助, 眞庭 謙昌, 神保 直江, 宮本 良文

  (NPO)日本肺癌学会, Apr. 2019, 肺癌, 59(2) (2), 210 - 211, Japanese

  [Refereed]


• ROS1-rearranged high-PD-L1-expressing lung adenocarcinoma manifesting as mediastinal tumor: A case report

  Ogawa H, Tanaka Yugo, Tachihara Motoko, Uehara Keiichiro, Shimizu Nahoko, Doi T, Hokka Daisuke, Maniwa Yoshimasa

  ROS proto-oncogene 1 receptor tyrosine kinase (ROS1)-rearranged lung cancer is rare and comprises only 1% of lung adenocarcinoma cases. It has recently been reported to have good response to crizotinib, a tyrosine kinase inhibitor of anaplastic lymphoma kinase. Driver oncogene mutations with approved therapies seldom coexist with a high expression of Programmed death-ligand 1 (PD-L1). The present case report describes a rare case of ROS1 rearrangement with high-PD-L1-expressing occult lung adenocarcinoma. A 32-year-old woman presented with chest pain and a prolonged cough. Chest computed tomography (CT) revealed a 57×36-mm tumor in the mediastinum, with no tumors detected in other regions. Positron emission tomography (PET)-CT showed a strong fluorodeoxyglucose accumulation in the tumor (SUVmax 13.2). Mediastinal tumor resection was completely resected using a video-assisted thoracic surgery approach. Pathological examination showed the tumor cells were positive for thyroid transcription factor 1, Napsin-A, ROS1, and PD-L1 (tumor proportion score >99%). ROS1 rearrangement was confirmed by fluorescence in situ hybridization. The mediastinal tumor was diagnosed as mediastinal lymph node metastasis of ROS1-rearranged PD-L1 high-expression undifferentiated lung adenocarcinoma (pathological stage 3, TxN2M0). Two months after the operation, the CT scan showed multiple mediastinum lymph nodes metastases with rapid tumor growth. The patient achieved a complete response after three cycles of S-1 plus cisplatin with concurrent radiotherapy 60 Gy/30 Fr.

  Jan. 2019, Oncol Lett, 17(1) (1), 488 - 491, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Temporary Bypass with 5-Fr Catheter for Reconstruction of Superior Vena Cava

  Nahoko Shimizu, Yugo Tanaka, Sanae Kuroda, Hayate Nakamura, Gaku Matsumoto, Suguru Mitsui, Shuto Sakai, Kazuhiro Minami, Kenji Kimura, Takeshi Okamoto, Daisuke Hokka, Yoshimasa Maniwa

  NLM (Medline), Dec. 2018, Kyobu geka. The Japanese journal of thoracic surgery, 71(13) (13), 1077 - 1080, Japanese, Domestic magazine

  Scientific journal


• 上大静脈の再建のための5-Frカテーテルによる一時的なバイパス

  Shimizu Nahoko, Tanaka Yugo, 黒田紗菜恵, 黒田紗奈恵, 中村速, 松本学, 光井卓, 酒井秀都, 南和宏, 木村賢司, Hokka Daisuke, Maniwa Yoshimasa

  Dec. 2018, 胸部外科, 71(13) (13), 1077 - 1080, Japanese

  [Refereed]

  Scientific journal


• 手術の工夫 上大静脈再建時の細径カテーテルによる一時外シャントの有用性

  Shimizu Nahoko, Tanaka Yugo, 黒田紗菜恵, 中村速, 松本学, 光井卓, 酒井秀都, 南和宏, 木村賢司, Hokka Daisuke, Maniwa Yoshimasa

  (株)南江堂, Dec. 2018, 胸部外科, 71(13号) (13号), 1077 - 1080, Japanese

  [Refereed]

  Scientific journal


• Natural history of bulla neogenesis for primary spontaneous pneumothorax: a propensity score analysis

  Tsuboshima K, Matoba Y, Wakahara T, Maniwa Yoshimasa

  OBJECTIVE: For patients with recurrent primary spontaneous pneumothorax, surgery has been thought to be an acceptable treatment. However, even if bulla is completely resected, postoperative recurrence is relatively common due to bulla neogenesis. Bulla neogenesis seems to develop naturally in younger patients compared with the elderly, as theorized till date. If the complete development of bulla neogenesis is confirmed, surgical resection can be performed as the radical treatment. Then, we evaluated the relationship between bulla neogenesis and age. METHODS: Between February 2009 and July 2018, we consecutively enrolled 276 patients who underwent primary bullectomy for primary spontaneous pneumothorax in our hospital. Finally, high-resolution computed tomography findings/observations of 155 eligible patients were evaluated retrospectively. The relationship between bulla neogenesis and age was evaluated using univariate and multivariate analyses and an inverse probability of treatment-weighted method using the propensity score. RESULTS: The study included 58 patients aged < 20 years and 97 aged ≥ 20 years. Bulla neogenesis was present in 34 patients (21.9%). Bulla neogenesis developed significantly at age < 20 compared with age ≥ 20 (44.8 vs. 8.2%). Univariate and multivariate analyses showed that age < 20 years was a significant factor associated with bulla neogenesis (P < 0.001 and P = 0.018, respectively). The inverse probability of treatment-weighted method showed that age < 20 years was a significant factor associated with bulla neogenesis (P = 0.0057, hazard ratio 4.79). CONCLUSIONS: Surgical treatment may be delayed in young patients (age < 20 years), because bulla neogenesis is not completely developed by this time for primary spontaneous pneumothorax.

  Dec. 2018, Gen Thorac Cardiovasc Surg, 67(5) (5), 464 - 469, English, Domestic magazine

  [Refereed]

  Scientific journal


• How to prevent adverse events of vascular stapling in thoracic surgery: recommendations based on a clinical and experimental study

  Shimizu Nahoko, Tanaka Yugo, Okamoto T, Doi T, Hokka Daisuke, Maniwa Yoshimasa

  Background: Advances in the development of staplers for pulmonary vessels have contributed to safe and convenient procedures in thoracic surgery. However, adverse events (AEs) can occur during vascular stapling and cause fatal hemorrhage. We aimed to assess the risk level of using the vessel stapling procedure to reduce such AEs. Methods: First, an animal experiment using pig cardiopulmonary blocks was conducted. Pulmonary arteries were closed with staplers under stressful conditions such as lifting or twisting; vessel stump endurance was analyzed through different methods. Second, AEs associated with clinical stapler use for pulmonary vessels were retrospectively reviewed by studying clinical videos of 263 patients. Results: In the animal experiment, the pressure resistance was significantly lower in the twisted group than in the no strain group (no strain vs. lifting: P=0.2008, no strain vs. twisting: P=0.002, no strain vs. twisting and lifting: P<0.0001). Regarding clinical stapler use, 754 staplers were used against the vessels. AEs occurred in 9 cases, and 7 cases were suspected to be caused by vessel tension. Conclusions: The pulmonary vessel stapling causes stress due to twisting and lifting that decreased stump durability. Avoiding such stress when using stapler for vessels leads to a safer thoracic surgery.

  Dec. 2018, J Thorac Dis, 10(12) (12), 6466 - 6471, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Successful Treatment of a Patient with Idiopathic Subglottic Stenosis

  Nahoko Shimizu, Yugo Tanaka, Sanae Kuroda, Hayate Nakamura, Gaku Matsumoto, Suguru Mitsui, Shuto Sakai, Kazuhiro Minami, Takeshi Okamoto, Takefumi Doi, Daisuke Hokka, Yoshimasa Maniwa

  NLM (Medline), Nov. 2018, Kyobu geka. The Japanese journal of thoracic surgery, 71(12) (12), 1018 - 1021, Japanese, Domestic magazine

  Scientific journal


• 臨床経験 外科治療が奏効した特発性声門下狭窄症

  Shimizu Nahoko, Tanaka Yugo, 黒田紗菜恵, 中村速, 松本学, 光井卓, 酒井秀都, 南和宏, Hokka Daisuke, Maniwa Yoshimasa

  (株)南江堂, Nov. 2018, 胸部外科, 71(12号) (12号), 1018 - 1021, Japanese

  [Refereed]

  Scientific journal


• 特発性憩室狭窄を有する患者の成功した治療法

  Shimizu Nahoko, Tanaka Yugo, 黒田紗菜恵, 黒田紗奈恵, 中村速, 松本学, 光井卓, 酒井秀都, 南和宏, Hokka Daisuke, Maniwa Yoshimasa

  Nov. 2018, 胸部外科, 71(12) (12), 1018 - 1021, Japanese

  [Refereed]

  Scientific journal


• 肺性肥大性骨関節症を合併したROS1融合遺伝子陽性肺癌の1例

  宮本夏希, 桂田直子, 小山貴与子, 中田恭介, 山本正嗣, 立原素子, 上領博, 西村善博, Tanaka Yugo, Maniwa Yoshimasa

  (NPO)日本肺癌学会, Oct. 2018, 肺癌, 58(5) (5), 371 - 371, Japanese

  [Refereed]

  Scientific journal


• 当科における肺切除後の同側再切除症例の検討

  Hokka Daisuke, 黒田紗菜恵, 光井卓, 松本学, 酒井秀都, 南和宏, 木村賢司, Shimizu Nahoko, Tanaka Yugo, Maniwa Yoshimasa

  Oct. 2018, 肺癌, 58(6号) (6号), 562, Japanese

  [Refereed]

  Scientific journal


• 当院における肺多形癌の臨床病理学的検討

  木村賢司, Tanaka Yugo, 黒田紗菜恵, 中村速, 松本学, 光井卓, 酒井秀都, 南和宏, Shimizu Nahoko, Hokka Daisuke, Maniwa Yoshimasa

  Oct. 2018, 肺癌, 58(6号) (6号), 656, Japanese

  [Refereed]

  Scientific journal


• 診断に苦慮した肺動脈内進展型原発性肺癌の1切除例

  黒田紗菜恵, Shimizu Nahoko, Hokka Daisuke, Tanaka Yugo, 神保直江, Maniwa Yoshimasa

  (NPO)日本肺癌学会, Oct. 2018, 肺癌, 58(6) (6), 564 - 564, Japanese

  [Refereed]

  Scientific journal


• 術後乳糜胸、膿胸、左総頸動脈出血を来し、迅速な対応により制御し得た左肺尖部胸壁浸潤癌の切除例

  Shimizu Nahoko, Tanaka Yugo, Hokka Daisuke, Maniwa Yoshimasa

  Oct. 2018, 肺癌, 58(6号) (6号), 613, Japanese

  [Refereed]

  Scientific journal


• 左下葉合併切除が必要であった巨大後縦隔脂肪肉腫の1例

  Tanaka Yugo, 黒田紗菜恵, 中村速, 松本学, 光井卓, 酒井秀都, 南和宏, 木村賢司, Shimizu Nahoko, Hokka Daisuke, Maniwa Yoshimasa

  Oct. 2018, 肺癌, 58(6号) (6号), 501, Japanese

  [Refereed]

  Scientific journal


• 胸腺非定型カルチノイドの2手術例

  光井卓, Tanaka Yugo, Shimizu Nahoko, Hokka Daisuke, 神保直江, Maniwa Yoshimasa

  (NPO)日本肺癌学会, Oct. 2018, 肺癌, 58(6) (6), 721 - 721, Japanese

  [Refereed]

  Scientific journal


• 気管支喘息を背景にもつ肺原発MALTリンパ腫に対し外科的切除を行った1例

  中村速, 黒田紗菜恵, 松本学, 光井卓, 酒井秀都, 南和宏, 木村賢司, Shimizu Nahoko, Hokka Daisuke, Tanaka Yugo, 神保直江, Maniwa Yoshimasa

  (NPO)日本肺癌学会, Oct. 2018, 肺癌, 58(6) (6), 740 - 740, Japanese

  [Refereed]

  Scientific journal


• ハイリスク症例に対する予防的気管支断端被覆についての検討

  酒井秀都, Tanaka Yugo, 黒田紗奈恵, 中村速, 光井卓, 松本学, 南和宏, 木村賢司, Shimizu Nahoko, Hokka Daisuke, Maniwa Yoshimasa

  Oct. 2018, 肺癌, 58(5号) (5号), 379, Japanese

  [Refereed]

  Scientific journal


• アプローチに検討を要した巨大後縦隔脂肪肉腫の一例

  松本学, Shimizu Nahoko, Hokka Daisuke, Tanaka Yugo, 神保直江, Maniwa Yoshimasa

  (NPO)日本肺癌学会, Oct. 2018, 肺癌, 58(6) (6), 497 - 497, Japanese

  [Refereed]

  Scientific journal


• [Continuous Chest Drainage Systems in Thoracic Surgery].

  Takefumi Doi, Yoshimasa Maniwa

  In the management of chest drain after thoracic surgery, it is important to egest fluid and air which accumulate in the pleural cavity and to gain information such as air leakage, bleeding or pus discharge. To achieve these purpose, continuous chest drainage system is necessary for thoracic surgery. In addition, we have to understand the particularity in the pleural cavity and the structure of continuous chest drainage system. Traditional drainage system is based on 3-bottle system. Recently, we can use new drainage system, such as Thopaz, which is called digital drainage system. There are several studies comparing digital drainage system with traditional drainage system, but the superiority of digital drainage system to traditional drainage system is not confirmed.

  Sep. 2018, Kyobu geka. The Japanese journal of thoracic surgery, 71(10) (10), 881 - 885, Japanese, Domestic magazine

  Scientific journal


• 縦隔発生の骨外性骨肉腫の一例

  岸田 雄治, 大野 良治, 関 紳一郎, 神保 直江, 伊藤 智雄, 田中 雄悟, 真庭 謙昌, 村上 卓道

  (公社)日本医学放射線学会, Sep. 2018, 日本医学放射線学会秋季臨床大会抄録集, 54回, S523 - S523, Japanese

  [Refereed]


• 切除範囲の決定にAFIが有用であった気管分岐部切除を伴う左肺全摘術の1例

  Maniwa Yoshimasa, Tanaka Yugo, Hokka Daisuke, Shimizu Nahoko

  Sep. 2018, 日本レーザー医学会誌, 39(3号) (3号), 246, Japanese

  [Refereed]

  Scientific journal


• 高田ら“食道亜全摘術後に生じた胃管気管瘻に対し、有茎肋間筋弁による気管修復術が有効であった1例”

  Maniwa Yoshimasa

  (NPO)日本呼吸器内視鏡学会, Sep. 2018, 気管支学, 40(5号) (5号), 414 - 448, Japanese

  [Refereed]

  Scientific journal


• 胸部手術における連続胸部ドレナージシステム

  Maniwa Yoshimasa

  Sep. 2018, 胸部外科, 71(10) (10), 881 - 885, Japanese

  [Refereed]

  Scientific journal


• 【胸部外科を支えるテクノロジーup to date】呼吸器領域 呼吸器外科における持続吸引装置

  Maniwa Yoshimasa

  Sep. 2018, 胸部外科, 71(10号) (10号), 881 - 885, Japanese

  [Refereed]

  Scientific journal


• Performance comparison between 18 F-FDG PET/CT Plus brain mri and conventional staging plus brain mri in staging of small cell lung carcinoma

  Yuji Kishida, Shinichiro Seki, Takeshi Yoshikawa, Tomoo Itoh, Yoshimasa Maniwa, Yoshihiro Nishimura, Yoshiharu Ohno

  American Roentgen Ray Society, Jul. 2018, American Journal of Roentgenology, 211(1) (1), 185 - 192, English, International magazine

  Scientific journal


• 初期臨床研修医を対象としたSOC(Sense of Coherence)によるレジリエンス測定とストレス対処能力自己評価

  木村真希, 在間梓, 坂口一彦, 伊藤智雄, Maniwa Yoshimasa, 河野誠司, Kobayashi Seimi

  (一社)日本医学教育学会, Jul. 2018, 医学教育, 49(Suppl.) (Suppl.), 236 - 236, Japanese

  [Refereed]

  Scientific journal


• 初期臨床研修における復職支援「Back-on-trackプログラム」の実践と課題

  木村真希, 坂口一彦, 伊藤智雄, Maniwa Yoshimasa, 河野誠司, 木村敦, Ichiro Sora

  (一社)日本医学教育学会, Jul. 2018, 医学教育, 49(Suppl.) (Suppl.), 237 - 237, Japanese

  [Refereed]

  Research society


• Critical role of the Ror-family of receptor tyrosine kinases in invasion and proliferation of malignant pleural mesothelioma cells.

  Takeshi Saji, Michiru Nishita, Hiroyuki Ogawa, Takefumi Doi, Yasuhiro Sakai, Yoshimasa Maniwa, Yasuhiro Minami

  Malignant pleural mesothelioma (MPM) is a highly aggressive tumor with poor prognosis and closely related to exposure to asbestos. MPM is a heterogeneous tumor with three main histological subtypes, epithelioid, sarcomatoid, and biphasic types, among which sarcomatoid type shows the poorest prognosis. The Ror-family of receptor tyrosine kinases, Ror1 and Ror2, is expressed in various types of tumor cells at higher levels and affects their aggressiveness. However, it is currently unknown whether they are expressed in and involved in aggressiveness of MPM. Here, we show that Ror1 and Ror2 are expressed in clinical specimens and cell lines of MPM with different histological features. Studies using MPM cell lines indicate that expression of Ror2 is associated tightly with high invasiveness of MPM cells, whereas Ror1 can contribute to their invasion in the absence of Ror2. However, both Ror1 and Ror2 promote proliferation of MPM cells. We also show that promoted invasion and proliferation of MPM cells by Ror signaling can be mediated by the Rho-family of small GTPases, Rac1, and Cdc42. These findings elucidate the critical role of Ror signaling in promoting invasion and proliferation of MPM cells.

  Jul. 2018, Genes to cells : devoted to molecular & cellular mechanisms, 23(7) (7), 606 - 613, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• [The Role of Video-assisted Thoracic Surgery in Multimodality Therapy].

  Yugo Tanaka, Takanori Matsumoto, Yoshimasa Maniwa

  Minimally invasive surgery is being widely performed for the management of lung cancers owing to rapid technological advances in surgical devices and techniques. In recent times, because chemotherapy and radiotherapy have both become less invasive treatment strategies, therapeutic opportunities for the use of multimodality therapy have been increasing. Minimally invasive surgery is an important component that requires additional improvements to derive the complete benefit of multimodality therapy. We have been actively performing video-assisted thoracic surgery(VATS) for the management of advanced lung cancers, as well as early lung cancers to reduce surgical stress in our patients, thereby enhancing the scope of multimodality therapy. Although some reports have demonstrated the efficacy of VATS for the management of early lung cancers, only a limited number of reports have discussed the advantage of VATS for the management of advanced lung cancers. In this report, we reviewed patients with advanced lung cancer (pathological stageⅡ or Ⅲ) in whom complete resection was performed between January 2011 and December 2016, and we examined the role of VATS as a component of multimodality therapy.

  Apr. 2018, Kyobu geka. The Japanese journal of thoracic surgery, 71(4) (4), 265 - 269, Japanese, Domestic magazine

  Scientific journal


• 肺膿瘍部に対する広範なドレーン損傷による有瘻性膿胸に対し集学的治療が奏功した1例

  木村賢司, Tanaka Yugo, 松本学, 光井卓, 松本高典, 西岡祐希, 金泰雄, 南和宏, Shimizu Nahoko, 小川裕行, Hokka Daisuke, Maniwa Yoshimasa

  Apr. 2018, 日本呼吸器外科学会雑誌, 32(3号) (3号), V9 - 3, Japanese

  [Refereed]

  Scientific journal


• 肺血管処理における自動縫合器の適正使用についての検討

  Shimizu Nahoko, Tanaka Yugo, 光井卓, 松本学, 松本高典, 西岡祐希, 金泰雄, 南和宏, 木村賢司, 小川裕行, Hokka Daisuke, Maniwa Yoshimasa

  Apr. 2018, 日本呼吸器外科学会雑誌, 32(3号) (3号), P44 - 7, Japanese

  [Refereed]

  Scientific journal


• 当院におけるびまん性肺疾患に対する胸腔鏡下肺生検の検討

  金泰雄, 小川裕行, 松本学, 光井卓, 西岡祐希, 松本高典, 南和宏, 木村賢司, Shimizu Nahoko, Hokka Daisuke, Tanaka Yugo, Maniwa Yoshimasa

  Apr. 2018, 日本呼吸器外科学会雑誌, 32(3号) (3号), P36 - 1, Japanese

  [Refereed]

  Scientific journal


• 転移性肺腫瘍との鑑別に苦慮した肺芽腫の1例

  松本学, Shimizu Nahoko, 光井卓, 西岡祐希, 松本高典, 金泰雄, 南和宏, 木村賢司, 小川裕行, Hokka Daisuke, Tanaka Yugo, 宮本良文, Maniwa Yoshimasa

  Apr. 2018, 日本呼吸器外科学会雑誌, 32(3号) (3号), P67 - 6, Japanese

  [Refereed]

  Scientific journal


• 早期肺腺癌におけるPsf3(GINS3)の発現とUFTの有効性についての検討

  木村賢司, Tanaka Yugo, Shimizu Nahoko, 小川裕行, Hokka Daisuke, 西尾渉, 吉村雅裕, Maniwa Yoshimasa

  Apr. 2018, 日本呼吸器外科学会雑誌, 32(3号) (3号), O19 - 1, Japanese

  [Refereed]

  Scientific journal


• 浸潤型胸腺腫の切除後の再発に対しreverse hockey stick incisionにて切除を行った1例

  Hokka Daisuke, 光井卓, 松本学, 西岡祐希, 松本高典, 金泰雄, 木村賢司, Shimizu Nahoko, 小川裕行, Tanaka Yugo, Maniwa Yoshimasa

  Apr. 2018, 日本呼吸器外科学会雑誌, 32(3号) (3号), V18 - 1, Japanese

  [Refereed]

  Scientific journal


• 術後横隔神経麻痺に対する胸腔鏡下横隔膜縫縮術の検討

  光井卓, Tanaka Yugo, 松本学, 松本高典, 西岡祐希, 金泰雄, 南和宏, 木村賢司, Shimizu Nahoko, 小川裕行, Hokka Daisuke, Maniwa Yoshimasa

  Apr. 2018, 日本呼吸器外科学会雑誌, 32(3号) (3号), P91 - 3, Japanese

  [Refereed]

  Scientific journal


• 縦隔内異所性副甲状腺腫に対し縦隔腫瘍摘除術を行った2例

  西岡祐希, 小川裕行, 光井卓, 松本学, 松本高典, 金泰雄, 南和宏, 木村賢司, Shimizu Nahoko, Hokka Daisuke, Tanaka Yugo, Maniwa Yoshimasa

  Apr. 2018, 日本呼吸器外科学会雑誌, 32(3号) (3号), P64 - 5, Japanese

  [Refereed]

  Scientific journal


• 集学的療法におけるビデオ支援胸部手術の役割

  Tanaka Yugo, 松本高典, Maniwa Yoshimasa

  Apr. 2018, 胸部外科, 71(4) (4), 265 - 269, Japanese

  [Refereed]

  Scientific journal


• 胸腺類基底細胞癌の1例

  松本学, 小川裕行, 光井卓, 西岡祐希, 松本高典, 金泰雄, 木村賢司, Shimizu Nahoko, Hokka Daisuke, Tanaka Yugo, Maniwa Yoshimasa

  Apr. 2018, 肺癌, 58(2号) (2号), 150 - 151, Japanese

  [Refereed]

  Scientific journal


• 胸腔鏡下手術における胸腔内高度癒着症例に対する当院での取り組み

  Tanaka Yugo, 松本学, 光井卓, 松本高典, 西岡祐希, 金泰雄, 南和宏, 木村賢司, Shimizu Nahoko, 小川裕行, Hokka Daisuke, Maniwa Yoshimasa

  Apr. 2018, 日本呼吸器外科学会雑誌, 32(3号) (3号), O13 - 4, Japanese

  [Refereed]

  Scientific journal


• 気管分岐部切除を伴う左肺全摘術にPCPSが有用であった1例

  Tanaka Yugo, 松本学, 光井卓, 松本高典, 西岡祐希, 金泰雄, 南和宏, 木村賢司, Shimizu Nahoko, 小川裕行, Hokka Daisuke, Maniwa Yoshimasa

  Apr. 2018, 日本呼吸器外科学会雑誌, 32(3号) (3号), V3 - 2, Japanese

  [Refereed]

  Scientific journal


• 癌細胞株と3次元in vitroモデルを応用した癌浸潤における候補遺伝子の解明

  南和宏, 木村賢司, Shimizu Nahoko, 小川裕行, Hokka Daisuke, Tanaka Yugo, Maniwa Yoshimasa

  Apr. 2018, 日本呼吸器外科学会雑誌, 32(3号) (3号), RO7 - 1, Japanese

  [Refereed]

  Scientific journal


• 開窓術を要した難治性膿胸の治療戦略について

  松本高典, Tanaka Yugo, 光井卓, 松本学, 西岡祐希, 金泰雄, 南和宏, 木村賢司, Shimizu Nahoko, 小川裕行, Hokka Daisuke, Maniwa Yoshimasa

  Apr. 2018, 日本呼吸器外科学会雑誌, 32(3号) (3号), P28 - 2, Japanese

  [Refereed]

  Research society


• 【肺癌の集学的治療の現況】手術と集学的治療 集学的治療における完全胸腔鏡下手術の役割

  Tanaka Yugo, 松本高典, Maniwa Yoshimasa

  Apr. 2018, 胸部外科, 71(4号) (4号), 265 - 269, Japanese

  [Refereed]

  Scientific journal


• SVC再建が必要な縦隔腫瘍切除において簡便な一時シャントが有用であった1例

  Shimizu Nahoko, Tanaka Yugo, 光井卓, 松本学, 松本高典, 西岡祐希, 金泰雄, 南和宏, 木村賢司, 小川裕行, Hokka Daisuke, Maniwa Yoshimasa

  Apr. 2018, 日本呼吸器外科学会雑誌, 32(3号) (3号), V6 - 5, Japanese

  [Refereed]

  Scientific journal


• Occult縦隔リンパ節転移を生じたROS1融合遺伝子陽性PD-L1強陽性肺腺癌の切除例

  小川裕行, Tanaka Yugo, 光井卓, 松本学, 松本高典, 西岡祐希, 金泰雄, 木村賢司, Shimizu Nahoko, Hokka Daisuke, Maniwa Yoshimasa

  Apr. 2018, 日本呼吸器外科学会雑誌, 32(3号) (3号), P71 - 8, Japanese

  [Refereed]

  Scientific journal


• IL-6 signalの阻害は、肺癌幹細胞を標的にした新規治療法になりうるか

  小川裕行, Shimizu Nahoko, Hokka Daisuke, Tanaka Yugo, 青井三千代, 青井貴之, Maniwa Yoshimasa

  Apr. 2018, 日本呼吸器外科学会雑誌, 32(3号) (3号), RO7 - 2, Japanese

  [Refereed]

  Scientific journal


• まい・てくにっく 胸腔鏡手術における葉間肺動脈露出のポイント

  Maniwa Yoshimasa

  Mar. 2018, 胸部外科, 71(3号) (3号), 179, Japanese

  [Refereed]

  Scientific journal


• Pleural Coating by 50% Glucose Solution Reduces Postoperative Recurrence of Spontaneous Pneumothorax

  TsuboshimaK, WakaharaT, MatobaY, Maniwa Yoshimasa

  BACKGROUND: Video-assisted thoracoscopic surgery is the standard procedure for treatment of spontaneous pneumothorax. However, postoperative recurrence is relatively common even if an absorbable covering sheet is used for reinforcement of the visceral pleura. Injection of a high concentration glucose solution to the thoracic cavity was recently reported to be effective in stopping postoperative air leakage or as a prophylactic procedure to prevent postoperative recurrence of spontaneous pneumothorax. Therefore, we used 50 mL of a 50% glucose solution for pleural coating (GPC) on an absorbable sheet intraoperatively to prevent postoperative recurrence of spontaneous pneumothorax. This is a retrospective study, and patient backgrounds are heterogeneous. We evaluated the feasibility of GPC using propensity scores to adjust for heterogeneity in their backgrounds. METHODS: Between January 2010 and December 2017, 376 patients who underwent video-assisted thoracoscopic surgery, with or without GPC, were evaluated. The GPC group consisted of 106 patients, and the non-GPC group consisted of 270. We analyzed the factors preventing postoperative recurrence of spontaneous pneumothorax by univariate analysis and Cox regression analysis with or without propensity score matching. RESULTS: Univariate analysis revealed age of 25 or older, smoking habit, no history of an ipsilateral operation, and GPC were significant factors preventing postoperative recurrence. GPC significantly prevented postoperative recurrence as shown by Cox regression analysis with propensity score matching (hazard ratio, 0.15; p = 0.014) and the inverse-probability of treatment weighted method (hazard ratio, 0.23; p = 0.0038). CONCLUSIONS: Intraoperative GPC significantly reduced the postoperative recurrence rate of spontaneous pneumothorax.

  Mar. 2018, Ann Thorac Surg, 106(1) (1), 184 - 191, English, International magazine

  [Refereed]

  Scientific journal


• [Giant Cell Tumor of the Rib;Report of a Case].

  Masahiko Takata, Yoshifumi Miyamoto, Yoshimasa Maniwa

  We report a rare case of giant cell tumor of the rib. A 33-year-old man was admitted to our hospital because of a recently appearing mass and pain in the right chest wall. Chest computed tomography and magnetic resonance imaging revealed a heterogeneous mass of 8-cm in diameter arising from and destroying the right 7th rib. The tumor was resected together with the 6th, 7th, and 8th ribs and the adjacent muscle and diaphragm. The pathological diagnosis was giant cell tumor of the bone. The patient has been free from recurrence or metastasis for 4 years after the operation.

  Feb. 2018, Kyobu geka. The Japanese journal of thoracic surgery, 71(2) (2), 156 - 159, Japanese, Domestic magazine

  Scientific journal


• 当院における自然気胸に対する単孔式胸腔鏡下手術の検討

  西岡祐希, 法華大助, 光井卓, 松本学, 松本高典, 金泰雄, 木村賢司, 清水奈保子, 土井健史, 小川裕行, 田中雄悟, Maniwa Yoshimasa

  Jan. 2018, 気管支学, 40(1号) (1号), 81, Japanese

  [Refereed]

  Scientific journal


• Fibroblasts promote the collective invasion of ameloblastoma tumor cells in a 3D coculture model.

  Takao Fuchigami, Hirofumi Koyama, Michiko Kishida, Yoshiaki Nishizawa, Mikio Iijima, Toshiro Kibe, Masahiro Ueda, Tohru Kiyono, Yoshimasa Maniwa, Norifumi Nakamura, Shosei Kishida

  Ameloblastoma is a benign tumor of the odontogenic epithelium with several histological subtypes. All subtypes of ameloblastoma contain abundant stroma; the tumor cells invade collectively into the surrounding tissues without losing intratumor cell attachments. However, the molecular mechanisms mediating ameloblastoma invasion remain unclear. Here, we evaluated the functional significance of the interactions between ameloblastoma tumor cells and stromal fibroblasts on collective cellular invasion using a three-dimensional cultivation method, double-layered collagen gel hemisphere (DL-CGH) culture. The AM-1 plexiform and AM-3 follicular human ameloblastoma cell lines and HFF-2 human fibroblasts were labeled with GFP and DsRed, respectively. Collective cellular invasion of ameloblastoma cells was assessed in the presence or absence of fibroblasts. Notably, without fibroblasts, AM-1 cells formed sharp, plexiform-like invasive processes, whereas AM-3 cells formed a series of blunt processes often observed during collective migration. In comparison, under the cocultures with HFF-2 fibroblasts, AM-3 cells formed tuft-like invasive processes and collectively invaded into outer layer more than that observed with AM-1 cells. Moreover, HFF-2 fibroblasts localized to the tips of the invasive tumor processes. These findings suggest that tumor-associated cells assist tumor cell invasion. Microscopic analysis of sectioned three-dimensional cultures revealed that AM-3/HFF-2 hemispheres were histologically similar to follicular ameloblastoma tumor samples. Therefore, our findings suggest that ameloblastoma subtypes exhibit distinct invasion patterns and that fibroblasts promote collective tumor invasion in follicular ameloblastoma.

  Dec. 2017, FEBS open bio, 7(12) (12), 2000 - 2007, English, International magazine

  Scientific journal


• 嚢胞内に発生した胸腺原発類基底細胞癌の1例

  松本学, 清水奈保子, 光井卓, 西岡裕希, 松本高典, 金泰雄, 木村賢司, 土井建史, 小川裕行, Hokka Daisuke, Tanaka Yugo, Maniwa Yoshimasa

  Dec. 2017, 肺癌, 57(7号) (7号), 892, Japanese

  [Refereed]

  Scientific journal


• 安全な胸腔鏡下肺葉切除術・縦隔リンパ節郭清のために

  Maniwa Yoshimasa

  Dec. 2017, 肺癌, 57(7号) (7号), 894, Japanese

  [Refereed]

  Scientific journal


• 難治性出血を合併した外傷性肺嚢胞の1例

  大隈 宏通, TANAKA YUGO, 内田 孝宏, OGAWA HIROYUKI, HOKKA DAISUKE, MANIWA YOSHIMASA

  A 43-year-old man was injured by collision with a car when he was riding a motorcycle. He was transported to our emergency department. Computed tomography showed displaced fractures of the left 1^st to 8^th ribs, hemopneumothorax, and a large traumatic pulmonary pseudocyst in the left lower lung lobe. He was put on a ventilator because breathing on his own became difficult. On the second day after he was injured, a hemorrhage occurred from the pulmonary pseudocyst and was stopped by spraying thrombin. However, on the third day, a massive hemorrhage occurred again. Therefore, pulmonary lobectomy of the left lower lobe was performed. His postoperative course was favorable. A traumatic pulmonary pseudocyst is rare and generally treated using conservative methods. However, surgical intervention is necessary in some cases with severe complications such as refractory hemorrhage, secondary infection, and severe air leak. We should consider surgical intervention as a therapeutic option for a traumatic pulmonary pseudocyst with refractory hemorrhage.

  The Japanese Association for Chest Surgery, Nov. 2017, 日本呼吸器外科学会雑誌, 31(7) (7), 885 - 889, Japanese

  Scientific journal


• 人工肺癌幹細胞を用いた、肺癌組織再構築と新規治療法開発の試み

  OGAWA HIROYUKI, AOI MICHIYO, AOI TAKASHI, MANIWA YOSHIMASA

  Sep. 2017, 肺癌, 57(5) (5), 416, Japanese

  Research society


• 診断的治療目的に手術した後縦隔神経節細胞腫の3例

  松本高典, OGAWA HIROYUKI, 酒井秀都, 金泰雄, 内田孝宏, 木村賢司, SHIMIZU NAHOKO, TANAKA YUGO, MANIWA YOSHIMASA

  Sep. 2017, 肺癌, 57(5) (5), 429, Japanese

  Research society


• 初発から15年の経過で肺転移を生じたgrade1髄膜腫の一例

  金泰雄, OGAWA HIROYUKI, 酒井秀都, 松本高典, 内田孝宏, 木村賢司, SHIMIZU NAHOKO, HOKKA DAISUKE, TANAKA YUGO, MANIWA YOSHIMASA

  Sep. 2017, 肺癌, 57(5) (5), 577, Japanese

  Research society


• 胸腺嚢胞に合併した胸腺癌の一切除例

  松本学, OGAWA HIROYUKI, 松本高典, 酒井秀都, 金泰雄, 内田孝宏, 木村賢司, SHIMIZU NAHOKO, TANAKA YUGO, MANIWA YOSHIMASA

  Sep. 2017, 肺癌, 57(5) (5), 564, Japanese

  Research society


• 気管支原性嚢胞からの発生が疑われた平滑筋肉腫の一切除例

  木村 賢司, OGAWA HIROYUKI, 酒井 秀都, 松本 高典, 内田 孝宏, 金 泰雄, SHIMIZU NAHOKO, HOKKA DAISUKE, TANAKA YUGO, MANIWA YOSHIMASA

  Sep. 2017, 肺癌, 57(5) (5), 568, Japanese

  Research society


• 気管支形成を伴う区域切除術を要した両側同時多発肺癌の手術例

  SHIMIZU NAHOKO, TANAKA YUGO, 酒井秀都, 松本高典, 内田孝宏, 金泰雄, 木村賢司, OGAWA HIROYUKI, HOKKA DAISUKE, MANIWA YOSHIMASA

  Sep. 2017, 肺癌, 57(5) (5), 409, Japanese

  Research society


• 右S2区域切除術後9年目に完全胸腔鏡下completion lobectomyを行った1例

  TANAKA YUGO, 酒井秀都, 松本高典, 内田孝宏, 金泰雄, 木村賢司, SHIMIZU NAHOKO, OGAWA HIROYUKI, HOKKA DAISUKE, MANIWA YOSHIMASA

  Sep. 2017, 肺癌, 57(5) (5), 410, Japanese

  Research society


• PRR11 immunoreactivity is a weak prognostic factor in non-mucinous invasive adenocarcinoma of the lung.

  Y Sakai, C Ohbayashi, E Yanagita, N Jimbo, K Kajimoto, T Sakuma, T Hirose, M Yoshimura, Y Maniwa, T Itoh

  INTRODUCTION: Proline-rich protein 11 (PRR11) functions in the progression of cell cycle, and silencing the PRR11 gene in lung cancer cells results in the inhibition of cellular proliferation, cell cycle progression, cell migration, invasion and colony formation. PRR11 may therefore be a therapeutic target in lung cancer. MATERIALS AND METHODS: Microarrays of surgical specimens of non-mucinous invasive adenocarcinoma of the lung, from 346 subjects that were not given preoperative therapy, were autoimmunostained with PRR11 and, except for trace and pseudo-positivity, assessed as "positive" at any proportion and intensity. RESULTS: PRR11 immunoreactivity demonstrated a tendency to associate with an aggressive phenotype (tumor size, vascular invasion, and adjuvant therapy) and some effect on overall survival (Hazard ratio 1.51). CONCLUSIONS: PRR11 may be a weak prognostic indicator of overall survival of patients with non-mucinous invasive adenocarcinoma of the lung.

  Sep. 2017, Pathologica, 109(3) (3), 133 - 139, English, International magazine

  [Refereed]

  Scientific journal


• Interleukin-6 blockade attenuates lung cancer tissue construction integrated by cancer stem cells

  Hiroyuki Ogawa, Michiyo Koyanagi-Aoi, Kyoko Otani, Yoh Zen, Yoshimasa Maniwa, Takashi Aoi

  Sep. 2017, SCIENTIFIC REPORTS, 7(1) (1), 12317 - 12317, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Feasibility of single-incision thoracoscopic surgery using a modified chest wall pulley for primary spontaneous pneumothorax: a propensity score matching analysis

  Kenji Tsuboshima, Machiko Nagata, Teppei Wakahara, Yasumi Matoba, Yoshimasa Maniwa

  Sep. 2017, SURGERY TODAY, 47(9) (9), 1129 - 1134, English, Domestic magazine

  [Refereed]

  Scientific journal


• 気管支原性嚢胞由来と考えられた前縦隔平滑筋肉腫の一例

  岸田 雄治, 関 紳一郎, 神保 直江, 伊藤 智雄, 真庭 謙昌, 大野 良治

  (公社)日本医学放射線学会, Aug. 2017, 日本医学放射線学会秋季臨床大会抄録集, 53回, S524 - S524, Japanese

  [Refereed]


• [Postoperative Intrathoracic Hemorrhage;Perioperative Prevention and Management].

  Yoshimasa Maniwa

  Postoperative intrathoracic hemorrhage is sometimes diagnosed in the thoracic cavity, while the patient is in the recovery room after undergoing thoracic surgery such as lung resection with thoracotomy or mediastinal surgery with a median sternotomy. The information from the chest tube is important to identify this kind of postoperative complication. When the condition becomes severe, the patient may develop hemorrhagic shock due to hemothorax and re-exploration to assess for bleeding and hemostasis may be required. The frequency of reoperation required in patients with postoperative hemorrhage is considered to be 1~3%. The bronchial artery, intercostal artery, and the intercostal vein are the most frequent sources of the hemorrhage. In some cases, the source of hemorrhage cannot be identified during re-exploration. However, intrathoracic hematoma removal by reoperation is essential to allow for adequate expansion of the remaining lung. Although a thoracoscope is usually inserted for re-exploration of the thoracic cavity initially, quick thoracotomy might be required to control hemorrhage, if the patient's vitals indicate rapid hemorrhage and subsequent shock.

  Jul. 2017, Kyobu geka. The Japanese journal of thoracic surgery, 70(8) (8), 688 - 691, Japanese, Domestic magazine

  Scientific journal


• 【胸部外科領域における合併症予防のための周術期管理】呼吸器領域 術後胸腔内出血 術中における予防と発生時の対応

  Maniwa Yoshimasa

  南江堂, Jul. 2017, 胸部外科, 70(8号) (8号), 688 - 691, Japanese

  [Refereed]

  Scientific journal


• Surgery for malignant lesions of the chest which extensively involved the mediastinum, lung, and heart

  Yugo Tanaka, Daisuke Hokka, Hiroyuki Ogawa, Nahoko Shimizu, Takeshi Inoue, Hiroshi Tanaka, Yutaka Okita, Yoshimasa Maniwa

  Springer Tokyo, Jul. 2017, General Thoracic and Cardiovascular Surgery, 65(7) (7), 365 - 373, English, Domestic magazine

  [Refereed]

  Scientific journal


• Reply

  Yugo Tanaka, Shinya Tane, Daisuke Hokka, Hiroyuki Ogawa, Yoshimasa Maniwa

  Elsevier USA, Jul. 2017, Annals of Thoracic Surgery, 104(1) (1), 370 - 370, English, International magazine

  [Refereed]

  Scientific journal


• 縦隔原発骨外性骨肉腫の1例

  内田 孝宏, TANAKA YUGO, SHIMIZU NAHOKO, 酒井 秀都, 松本 高典, 金 泰雄, 木村 賢司, OGAWA HIROYUKI, HOKKA DAISUKE, MANIWA YOSHIMASA

  Jun. 2017, 肺癌, 57(3) (3), e252, Japanese

  Scientific journal


• iPS細胞を巡る最新の動向と今後の研究展開 人工癌幹細胞と癌オルガノイドを用いた癌幹細胞研究

  AOI TAKASHI, 石田 諒, OGAWA HIROYUKI, AOI MICHIYO, KAKEJI YOSHIHIRO, MANIWA YOSHIMASA

  Jun. 2017, Cytometry Research, 27(Suppl) (Suppl), 36, Japanese

  Research society


• 続発性気胸に対する手術症例の検討

  HOKKA DAISUKE, 松本 高典, 酒井 秀都, 内田 孝宏, 金 泰雄, 木村 賢司, SHIMIZU NAHOKO, OGAWA HIROYUKI, TANAKA YUGO, MANIWA YOSHIMASA

  (NPO)日本呼吸器外科学会, Apr. 2017, 日本呼吸器外科学会雑誌, 31(3) (3), O10 - 2, Japanese

  Research society


• 術後横隔神経麻痺に対する横隔膜縫縮術の検討

  SHIMIZU NAHOKO, TANAKA YUGO, 酒井 秀都, 松本 高典, 内田 孝宏, 金 泰雄, 木村 賢司, OGAWA HIROYUKI, HOKKA DAISUKE, MANIWA YOSHIMASA

  Apr. 2017, 日本呼吸器外科学会雑誌, 31(3) (3), P71 - 4, Japanese

  Research society


• 血液透析患者に対する原発性肺癌手術症例の検討

  木村 賢司, OGAWA HIROYUKI, TANAKA YUGO, 酒井 秀都, 松本 高典, 内田 孝宏, 金 泰雄, SHIMIZU NAHOKO, HOKKA DAISUKE, MANIWA YOSHIMASA

  Apr. 2017, 日本呼吸器外科学会雑誌, 31(3) (3), P103 - 6, Japanese

  Research society


• 胸腺腫に関連した新規疾患概念、抗PIT-1抗体症候群

  松本 高典, OGAWA HIROYUKI, 酒井 秀都, 金 泰雄, 内田 孝宏, 木村 賢司, SHIMIZU NAHOKO, TANAKA YUGO, 坂東 弘教, IGUCHI GENZO, TAKAHASHI YUTAKA, MANIWA YOSHIMASA

  (NPO)日本呼吸器外科学会, Apr. 2017, 日本呼吸器外科学会雑誌, 31(3) (3), O14 - 6, Japanese

  Research society


• 気管分岐部切除を要した右肺全摘の1例

  酒井 秀都, TANAKA YUGO, 松本 高典, 内田 孝宏, 金 泰雄, 木村 賢司, SHIMIZU NAHOKO, OGAWA HIROYUKI, HOKKA DAISUKE, MANIWA YOSHIMASA

  Apr. 2017, 日本気管食道科学会会報, 68(2) (2), s20, Japanese

  Scientific journal


• 完全鏡視下手術手技を用いた拡大手術についての検討

  TANAKA YUGO, 酒井 秀都, 松本 高典, 内田 孝宏, 金 泰雄, 木村 賢司, SHIMIZU NAHOKO, OGAWA HIROYUKI, HOKKA DAISUKE, MANIWA YOSHIMASA

  Apr. 2017, 日本呼吸器外科学会雑誌, 31(3) (3), O19 - 3, Japanese

  Research society


• 外科的切除によって著明な改善を認めた胸壁発生の腫瘍性低リン血症性骨軟化症の一例

  金 泰雄, OGAWA HIROYUKI, 酒井 秀都, 松本 高典, 内田 孝宏, 木村 賢司, SHIMIZU NAHOKO, HOKKA DAISUKE, TANAKA YUGO, MANIWA YOSHIMASA

  Apr. 2017, 日本呼吸器外科学会雑誌, 31(3) (3), 68 - 6, Japanese

  Scientific journal


• Volume reductionにて症状が改善した縦隔原発骨外性骨肉腫の1例

  SHIMIZU NAHOKO, TANAKA YUGO, 酒井 秀都, 松本 高典, 内田 孝宏, 金 泰雄, 木村 賢司, OGAWA HIROYUKI, HOKKA DAISUKE, MANIWA YOSHIMASA

  Apr. 2017, 日本呼吸器外科学会雑誌, 31(3) (3), 37 - 1, Japanese

  Scientific journal


• 骨・軟部悪性腫瘍における肺転移切除例の治療成績

  河本旭哉, 原仁美, 深瀬直政, 森下雅之, 片山悦子, 竹森俊幸, Tanaka Yugo, Maniwa Yoshimasa, 黒田良祐, 秋末敏宏

  (公社)日本整形外科学会, Mar. 2017, 日本整形外科学会雑誌, 91(2) (2), S607 - S607, Japanese

  [Refereed]

  Scientific journal


• A novel thymoma-associated autoimmune disease: Anti-PIT-1 antibody syndrome.

  Hironori Bando, Genzo Iguchi, Yasuhiko Okimura, Yukiko Odake, Kenichi Yoshida, Ryusaku Matsumoto, Kentaro Suda, Hitoshi Nishizawa, Hidenori Fukuoka, Atsuko Mokubo, Katsuyoshi Tojo, Yoshimasa Maniwa, Wataru Ogawa, Yutaka Takahashi

  Anti-PIT-1 antibody syndrome has recently been reported and characterized by acquired growth hormone (GH), prolactin (PRL), and thyroid-stimulating hormone (TSH) deficiencies associated with autoimmunity to a pituitary specific transcription factor PIT-1, which plays an essential role in GH-, PRL-, and TSH-producing cells. Although circulating anti-PIT-1 antibody and PIT-1-reactive cytotoxic T cells (CTLs) were detected in the patients, the pathophysiology and precise mechanisms for the autoimmunity remain unclarified. During the follow up, thymoma was diagnosed in all 3 cases with anti-PIT-1 antibody syndrome. Immunohistochemical analysis revealed that PIT-1 was strongly expressed in neoplastic cortical thymic epithelial cells. Importantly, after thymectomy, the titer of anti-PIT-1 antibody decreased and reactivity of CTLs toward PIT-1 diminished. These data strongly suggest that the aberrant expression of PIT-1 in the thymoma plays a causal role in the development of this syndrome. Thus, we define that this syndrome is a novel thymoma-associated autoimmune disease.

  Feb. 2017, Scientific reports, 7, 43060 - 43060, English, International magazine

  Scientific journal


• 広背筋弁被覆、左右分離換気により良好な経過を得た食道癌術後胃管気管支瘻の1例

  内田 孝宏, 大隈 宏通, 奥田 祐亮, 清水 奈保子, 小川 裕行, 法華 大助, 田中 雄悟, 眞庭 謙昌, 中村 哲, 掛地 吉弘

  (NPO)日本気管食道科学会, Feb. 2017, 日本気管食道科学会会報, 68(1) (1), 40 - 45, Japanese


• 扁桃転移を伴った肺大細胞神経内分泌癌の1例

  奥田 祐亮, 田中 雄悟, 清水 奈保子, 小川 裕行, 法華 大助, 眞庭 謙昌

  (NPO)日本肺癌学会, Feb. 2017, 肺癌, 57(1) (1), 41 - 45, Japanese


• Modified Chest Wall Pulley for Lung Excision during Single-Incision Thoracoscopic Surgery for Primary Spontaneous Pneumothorax.

  Kenji Tsuboshima, Machiko Nagata, Teppei Wakahara, Yasumi Matoba, Yoshimasa Maniwa

  We reported the feasibility of single-incision thoracoscopic surgery bullectomy using a chest wall pulley for lung excision (PulLE) in patients with primary spontaneous pneumothorax (PSP). PulLE has many merits including comfort of manipulation, cosmetic advantages, etc., compared to other procedures. However, our method was utilized for relatively straightforward cases. The PulLE was contraindicated for PSPs with multiple or comprehensive bullae. Therefore, we developed the modified PulLE (mPulLE) to treat such cases in February 2015. Although one chest wall pulley is placed in the thoracic cavity for a PulLE, two are used for an mPulLE. Herein, we describe the mPulLE technique.

  Dec. 2016, Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia, 22(6) (6), 359 - 362, English, Domestic magazine

  Scientific journal


• 肺結節切除標本にびまん性特発性神経内分泌細胞過形成を認めた1例

  酒井 秀都, 松本 高典, 内田 孝宏, 金 泰雄, 木村 賢司, 清水 奈保子, 小川 裕行, 法華 大助, 田中 雄悟, 真庭 謙昌, 神保 直江, 酒井 康裕

  (NPO)日本肺癌学会, Dec. 2016, 肺癌, 56(7) (7), 1075 - 1076, Japanese

  [Refereed]


• 悪性黒色腫の肺転移と思われた1例

  神保 直江, 大谷 恭子, 酒井 康裕, 川本 めぐみ, 羽間 大祐, 堂國 良太, 吉崎 飛鳥, 桐生 辰徳, 関谷 怜奈, 寺下 智美, 梅澤 佳乃子, 尾野 慶彦, 三輪 菜々子, 桂田 雅大, 徳永 俊太郎, 桂田 直子, 田村 大介, 永野 達也, 中田 恭介, 山本 正嗣, 立原 素子, 小林 和幸, 西村 善博, 酒井 秀都, 内田 孝宏, 金 泰雄, 木村 賢司, 清水 奈保子, 小川 裕行, 法華 大介, 田中 雄悟, 眞庭 謙昌, 大野 良治

  (NPO)日本肺癌学会, Dec. 2016, 肺癌, 56(7) (7), 1077 - 1078, Japanese

  [Refereed]


• Association between postoperative bulla neogenesis at the staple line and resected lung weight for primary spontaneous pneumothorax: a retrospective study using the inverse-probability of treatment weighted method in patients grouped according to age

  Kenji Tsuboshima, Machiko Nagata, Teppei Wakahara, Yasumi Matoba, Yoshimasa Maniwa

  Dec. 2016, JOURNAL OF THORACIC DISEASE, 8(12) (12), 3676 - 3681, English, International magazine

  [Refereed]

  Scientific journal


• PET-MRI所見に基づく肺・下鼻甲介・腎生検が原疾患の診断に有効であった二次性血球貪食性リンパ組織球症の1例

  河原 仁守, 尾藤 祐子, 會田 洋輔, 橘木 由美子, 中井 優美子, 清水 奈保子, 眞庭 謙昌, 西井 達矢, 伊藤 智雄, 藤村 順也, 忍頂寺 毅史, 高藤 哲, 坊 亮輔, 山本 暢之, 森 健, 西村 範行, 飯島 一誠

  (一社)日本小児血液・がん学会, Nov. 2016, 日本小児血液・がん学会雑誌, 53(4) (4), 349 - 349, Japanese

  [Refereed]


• 肺結節切除標本内にびまん性特発性神経内分泌細胞過形成と多発tumorletを認めた1例

  酒井秀都, Tanaka Yugo, 松本高典, 内田孝宏, 金泰雄, 木村賢司, Shimizu Nahoko, Ogawa Hiroyuki, Hokka Daisuke, Maniwa Yoshimasa

  Nov. 2016, 肺癌, 56(6号) (6号), 590, Japanese

  [Refereed]

  Scientific journal


• 転移性脳腫瘍の発見から1年後に診断・手術に至ったpT1aN0M1bの原発性肺腺癌の1例

  金泰雄, Tanaka Yugo, 酒井秀都, 松本高典, 内田孝宏, 木村賢司, Shimizu Nahoko, Ogawa Hiroyuki, Hokka Daisuke, Maniwa Yoshimasa

  Nov. 2016, 肺癌, 56(6号) (6号), 779, Japanese

  [Refereed]

  Scientific journal


• 全身PET/MRI、MRI、PET/CT及び通常画像検査における胸腺上皮性腫瘍の病期診断能の比較

  大野良治, 岸田雄二, 関紳一郎, 吉川武, 田村大介, Tanaka Yugo, 立原素子, 小林和幸, 酒井康裕, Maniwa Yoshimasa, 西村善博

  (NPO)日本肺癌学会, Nov. 2016, 肺癌, 56(6号) (6号), 534 - 534, Japanese

  [Refereed]

  Scientific journal


• 小細胞癌に対する外科的治療効果についての検討

  Tanaka Yugo, 酒井秀都, 松本高典, 内田孝宏, 金泰雄, 木村賢司, Shimizu Nahoko, Ogawa Hiroyuki, Hokka Daisuke, 多根健太, 西尾渉, 吉村雅裕, Maniwa Yoshimasa

  Nov. 2016, 肺癌, 56(6号) (6号), 548, Japanese

  [Refereed]

  Scientific journal


• 左上区域支入口部腫瘍に対して完全鏡視下左上区域切除術を行った1例

  内田孝宏, Tanaka Yugo, 酒井秀都, 松本高典, 金泰雄, 木村賢司, Shimizu Nahoko, Ogawa Hiroyuki, Hokka Daisuke, Maniwa Yoshimasa

  Nov. 2016, 肺癌, 56(6号) (6号), 717, Japanese

  [Refereed]

  Scientific journal


• 胸壁浸潤肺癌手術に対する低侵襲化への工夫

  Hokka Daisuke, 酒井秀都, 金泰雄, 内田孝宏, 木村賢司, Shimizu Nahoko, Tanaka Yugo, Maniwa Yoshimasa

  Nov. 2016, 肺癌, 56(6号) (6号), 497, Japanese

  [Refereed]

  Scientific journal


• 急速に増大し縦隔偏位をきたした肺癌合併巨大肺嚢胞の一例

  木村賢司, Tanaka Yugo, 酒井秀都, 松本高典, 内田孝宏, 金泰雄, Shimizu Nahoko, Ogawa Hiroyuki, Hokka Daisuke, Maniwa Yoshimasa

  Nov. 2016, 肺癌, 56(6号) (6号), 842, Japanese

  [Refereed]

  Scientific journal


• 完全胸腔鏡下における予防的気管支断端被覆症例の検討

  Shimizu Nahoko, Tanaka Yugo, 酒井秀都, 松本高典, 内田孝宏, 金泰雄, 木村賢司, Ogawa Hiroyuki, Hokka Daisuke, Maniwa Yoshimasa

  Nov. 2016, 肺癌, 56(6号) (6号), 546, Japanese

  [Refereed]

  Scientific journal


• 右房内に進展した巨大浸潤性胸腺腫に対し人工心肺を用い完全切除可能であった1例

  Tanaka Yugo, 酒井秀都, 松本高典, 内田孝宏, 金泰雄, 木村賢司, Shimizu Nahoko, Ogawa Hiroyuki, Hokka Daisuke, Maniwa Yoshimasa

  Nov. 2016, 肺癌, 56(6号) (6号), 503, Japanese

  [Refereed]

  Scientific journal


• 咽頭転移を生じた大細胞神経内分泌癌の1例

  松本学, 小川裕行, 松本高典, 酒井秀都, 金泰雄, 内田孝宏, 木村賢司, Shimizu Nahoko, Hokka Daisuke, 田中雄悟, Maniwa Yoshimasa

  Nov. 2016, 肺癌, 56(6号) (6号), 862, Japanese

  [Refereed]

  Scientific journal


• Re-Assessment of Intentional Extended Segmentectomy for Clinical T1aN0 Non-Small Cell Lung Cancer

  Wataru Nishio, Masahiro Yoshimura, Yoshimasa Maniwa, Yoshitaka Kitamura, Kenta Tane, Daisuke Takenaka, Shuji Adachi

  Nov. 2016, ANNALS OF THORACIC SURGERY, 102(5) (5), 1702 - 1710, English, International magazine

  [Refereed]

  Scientific journal


• 3次元肺癌CT検診用コンピューター支援診断システムの低線量化における再構成の影響に関する比較検討

  大野良治, 岸田雄二, 関紳一郎, 吉川武, 田村大介, Tanaka Yugo, 立原素子, 小林和幸, 酒井康裕, Maniwa Yoshimasa, 西村善博

  (NPO)日本肺癌学会, Nov. 2016, 肺癌, 56(6号) (6号), 506 - 506, Japanese

  [Refereed]

  Scientific journal


• 3次元CTコンピューター体積測定システムの臨床応用 経過観察CTによる良・悪性結節鑑別能評価

  大野良治, 岸田雄二, 関紳一郎, 吉川武, 田村大介, Tanaka Yugo, 立原素子, 小林和幸, 酒井康裕, Maniwa Yoshimasa, 西村善博

  (NPO)日本肺癌学会, Nov. 2016, 肺癌, 56(6号) (6号), 673 - 673, Japanese

  [Refereed]

  Scientific journal


• Psf3 is a prognostic biomarker in lung adenocarcinoma: a larger trial using tissue microarrays of 864 consecutive resections

  Shunsuke Tauchi, Yasuhiro Sakai, Shuntaro Fujimoto, Hiroyuki Ogawa, Shinya Tane, Daisuke Hokka, Yugo Tanaka, Wataru Nishio, Masahiro Yoshimura, Emmy Yanagita, Tomoo Itoh, Yoshitake Hayashi, Yoshimasa Maniwa

  Oct. 2016, EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, 50(4) (4), 758 - 764, English, International magazine

  [Refereed]

  Scientific journal


• Inflammatory myofibroblastic tumorの1例

  岸田 雄治, 大野 良治, 関 紳一郎, 真庭 謙昌, 酒井 康裕, 伊藤 智雄, 杉村 和朗

  (公社)日本医学放射線学会, Aug. 2016, 日本医学放射線学会秋季臨床大会抄録集, 52回, S549 - S550, Japanese


• x Gateを用いた単孔式自然気胸手術の有用性の検討

  Hokka Daisuke, 酒井秀都, 金秦雄, 内田孝宏, 木村賢司, Shimizu Nahoko, Tanaka Yugo, Maniwa Yoshimasa

  Aug. 2016, 日本気胸・嚢胞性肺疾患学会雑誌, 16(1号) (1号), 40, Japanese

  [Refereed]

  Scientific journal


• 病理組織診断で大細胞神経内分泌癌の中咽頭転移が判明した1例

  大隈宏通, 奥田祐亮, 内田孝宏, Shimizu Nahoko, Ogawa Hiroyuki, Hokka Daisuke, Tanaka Yugo, Maniwa Yoshimasa

  Apr. 2016, 肺癌, 56(2号) (2号), 138, Japanese

  [Refereed]

  Scientific journal


• 体細胞初期化因子導入による肺癌幹細胞誘導

  Ogawa Hiroyuki, Hokka Daisuke, Tanaka Yugo, 青井貴之, Maniwa Yoshimasa

  Apr. 2016, 日本呼吸器外科学会雑誌, 30(3号) (3号), P76 - 4, Japanese

  [Refereed]

  Scientific journal


• 周術期に感染性大動脈瘤を合併した降下性壊死性縦隔炎の1手術例

  内田孝宏, 大隈宏通, 奥田祐亮, Shimizu Nahoko, Ogawa Hiroyuki, Hokka Daisuke, Tanaka Yugo, Maniwa Yoshimasa

  Apr. 2016, 日本呼吸器外科学会雑誌, 30(3号) (3号), P62 - 5, Japanese

  [Refereed]

  Scientific journal


• 外傷性肺嚢胞に対して緊急手術を要した1例

  大隈宏通, 内田孝宏, 奥田祐亮, Shimizu Nahoko, Ogawa Hiroyuki, 田根慎也, Hokka Daisuke, Tanaka Yugo, Maniwa Yoshimasa

  Apr. 2016, 日本呼吸器外科学会雑誌, 30(3号) (3号), P73 - 3, Japanese

  [Refereed]

  Scientific journal


• 右鎖骨下動脈再建を要した肺尖部胸壁浸潤癌の1切除例

  Tanaka Yugo, 内田孝宏, 大隈宏通, 奥田祐亮, Shimizu Nahoko, Ogawa Hiroyuki, Hokka Daisuke, Maniwa Yoshimasa

  Apr. 2016, 日本呼吸器外科学会雑誌, 30(3号) (3号), V8 - 1, Japanese

  [Refereed]

  Scientific journal


• pT1N1非小細胞癌切除例におけるリンパ節病変の進展と予後に関する検討

  Tanaka Yugo, 奥田祐亮, 内田孝宏, 大隈宏通, Shimizu Nahoko, Ogawa Hiroyuki, Hokka Daisuke, Maniwa Yoshimasa, 西尾渉, 吉村雅裕

  Apr. 2016, 日本呼吸器外科学会雑誌, 30(3号) (3号), RO1 - 7, Japanese

  [Refereed]

  Scientific journal


• 1cm以下微小肺癌切除例の検討

  奥田祐亮, 内田孝宏, 大隈宏通, Shimizu Nahoko, Ogawa Hiroyuki, Hokka Daisuke, Tanaka Yugo, Maniwa Yoshimasa, 西尾渉, 吉村雅裕

  Apr. 2016, 日本呼吸器外科学会雑誌, 30(3号) (3号), RO1 - 1, Japanese

  [Refereed]

  Scientific journal


• The Use of Oxidized Regenerated Cellulose for Video-Assisted Thoracic Surgery

  Yugo Tanaka, Shinya Tane, Daisuke Hokka, Hiroyuki Ogawa, Yoshimasa Maniwa

  Feb. 2016, ANNALS OF THORACIC SURGERY, 101(2) (2), 786 - 788, English, International magazine

  [Refereed]

  Scientific journal


• Is Thymomectomy Alone Appropriate for Stage I (T1N0M0) Thymoma? Results of a Propensity-Score Analysis

  Kazuo Nakagawa, Kohei Yokoi, Jun Nakajima, Fumihiro Tanaka, Yoshimasa Maniwa, Makoto Suzuki, Takeshi Nagayasu, Hisao Asamura

  Feb. 2016, ANNALS OF THORACIC SURGERY, 101(2) (2), 520 - 526, English, International magazine

  [Refereed]

  Scientific journal


• Efficacy of bilateral thoracoscopic sympathectomy in a patient with catecholaminergic polymorphic ventricular tachycardia

  Katsunori Okajima, Kunihiko Kiuchi, Kiminobu Yokoi, Jin Teranishi, Kosuke Aoki, Akira Shimane, Yoshihide Nakamura, Motoko Kimura, Yoshio Horikawa, Masato Yoshida, Yoshimasa Maniwa

  Elsevier, Feb. 2016, Journal of Arrhythmia, 32(1) (1), 62 - 66, English, Domestic magazine

  [Refereed]

  Scientific journal


• Surgical treatment of air way disease

  Yoshimasa Maniwa

  Jan. 2016, JOURNAL OF THORACIC DISEASE, 8(1) (1), E78 - E82, English, International magazine

  [Refereed]

  Scientific journal


• Novel paravertebral block during single-incision thoracoscopic surgery for primary spontaneous pneumothorax

  Kenji Tsuboshima, Machiko Nagata, Teppei Wakahara, Yasumi Matoba, Wataru Nishio, Yoshimasa Maniwa

  Springer-Verlag Tokyo, Jan. 2016, General Thoracic and Cardiovascular Surgery, 64(1) (1), 58 - 61, English, Domestic magazine

  [Refereed]

  Scientific journal


• Significant role of Psf3 expression in non-small-cell lung cancer

  Shinya Tane, Yasuhiro Sakai, Daisuke Hokka, Hiromichi Okuma, Hiroyuki Ogawa, Yugo Tanaka, Kazuya Uchino, Wataru Nishio, Masahiro Yoshimura, Yoshimasa Maniwa

  Nov. 2015, CANCER SCIENCE, 106(11) (11), 1625 - 1634, English, International magazine

  [Refereed]

  Scientific journal


• Operative outcomes of thoracoscopic lobectomy for non-small-cell lung cancer

  Shinya Tane, Wataru Nishio, Hiromichi Okuma, Hiroyuki Ogawa, Daisuke Hokka, Kenta Tane, Yugo Tanaka, Kazuya Uchino, Masahiro Yoshimura, Yoshimasa Maniwa

  SAGE Publications Inc., Oct. 2015, Asian Cardiovascular and Thoracic Annals, 23(8) (8), 950 - 957, English, International magazine

  [Refereed]

  Scientific journal


• Relationship between postoperative bulla neogenesis at the staple line and the resected lung volume in primary spontaneous pneumothorax

  Kenji Tsuboshima, Machiko Nagata, Teppei Wakahara, Yasumi Matoba, Shoichi Matsumoto, Yoshimasa Maniwa

  Springer Tokyo, Oct. 2015, General Thoracic and Cardiovascular Surgery, 63(10) (10), 572 - 575, English, Domestic magazine

  [Refereed]

  Scientific journal


• Ruptured thymoma causing a hemothorax: A case report

  Daisuke Hokka, Hiroyuki Ogawa, Shinya Tane, Yugo Tanaka, Shunsuke Tauchi, Yoshimasa Maniwa

  Sep. 2015, ONCOLOGY LETTERS, 10(3) (3), 1810 - 1812, English, International magazine

  [Refereed]

  Scientific journal


• 肺炎症性偽腫瘍の1切除例

  内田 孝宏, 大隈 宏通, 清水 奈保子, 奥田 祐亮, 小川 裕行, 田根 慎也, 法華 大助, 田中 雄悟, 眞庭 謙昌, 田村 大介, 立原 素子, 上領 博, 小林 和幸, 西村 善博, 酒井 康裕, 神山 久信, 大野 良治

  (NPO)日本肺癌学会, Aug. 2015, 肺癌, 55(4) (4), 317 - 317, Japanese


• 肺癌と鑑別を要した炎症性結節の1例

  大谷 恭子, 神保 直江, 酒井 康裕, 寺下 智美, 三輪 菜々子, 西村 春佳, 國政 啓, 徳永 俊太郎, 畠山 由記久, 永野 達也, 新家 治子, 堀 朱矢, 櫨木 暢子, 中田 恭介, 田村 大介, 立原 素子, 上領 博, 小林 和幸, 西村 善博, 内田 孝宏, 大隅 宏通, 清水 奈保子, 奥田 祐亮, 小川 裕行, 法華 大助, 田根 慎也, 田中 雄悟, 眞庭 謙昌, 神山 久信, 大野 良治

  (NPO)日本肺癌学会, Aug. 2015, 肺癌, 55(4) (4), 317 - 317, Japanese


• Outcomes of segmentectomy for cT1BN0M0 lung adenocarcinoma and squamous cell carcinoma: A possible association with pathological invasion

  Hiroyuki Ogawa, Kazuya Uchino, Yugo Tanaka, Nahoko Shimizu, Yusuke Okuda, Kenta Tane, Daisuke Hokka, Shinya Tane, Shunsuke Tauchi, Wataru Nishio, Yoshimasa Maniwa, Masahiro Yoshimura

  European Association for Cardio-Thoracic Surgery, Jul. 2015, European Journal of Cardio-thoracic Surgery, 48(1) (1), 77 - 82, English, International magazine

  [Refereed]

  Scientific journal


• 縦隔成熟奇形腫胸腔内穿破の1例

  大隈宏通, Tane Shinya, 内田孝宏, 奥田祐亮, 清水奈保子, Ogawa Hiroyuki, Hokka Daisuke, 田中雄悟, Maniwa Yoshimasa

  南江堂, Jul. 2015, 胸部外科, 68(7号) (7号), 546 - 549, Japanese

  [Refereed]

  Scientific journal


• Efficacy of adjuvant chemotherapy for lung adenocarcinoma patients with positive pleural lavage cytology findings

  Hiroyuki Ogawa, Kazuya Uchino, Yugo Tanaka, Nahoko Shimizu, Yusuke Okuda, Kenta Tane, Shunsuke Tauchi, Wataru Nishio, Yoshimasa Maniwa, Masahiro Yoshimura

  Jul. 2015, INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY, 21(1) (1), 34 - 39, English, International magazine

  [Refereed]

  Scientific journal


• [Perforation of the Mediastinal Mature Teratoma;Report of a Case]

  OkumaH, Tane Shinya, UchidaT, OkudaY, ShimizuN, Ogawa Hiroyuki, Hokka Daisuke, TanakaY, Maniwa Yoshimasa

  The mediastinal mature teratoma is uncommon in adult and sometimes ruptures. We present a case of perforation of mediastinal mature teratoma. A 22-year-old man, who had been scheduled for surgery to resect anterior mediastinal teratoma, was referred to our hospital due to sudden chest pain. The enhanced computed tomography findings suggested a perforation of the teratoma and the emergency surgery was performed. Extirpation of the tumor with partial resection of right upper lung, pericardium, and superior vena cava was performed. The histological diagnosis was mature teratoma and the defect of the mediastinal pleura was found to be the site of perforation. The patient was well and discharged from the hospital without complications.

  Jul. 2015, Kyobu Geka, 68(7) (7), 546 - 9, English, Domestic magazine

  [Refereed]

  Scientific journal


• Single-incision thoracoscopic surgery using a chest wall pulley for lung excision in patients with primary spontaneous pneumothorax.

  Kenji Tsuboshima, Teppei Wakahara, Yasumi Matoba, Harunori Miyauchi, Chikako Hayashi, Iwao Kobayashi, Hiroaki Oue, Yoshihisa Watanabe, Toru Ono, Yoshimasa Maniwa

  PURPOSE: The aim of the study was to evaluate the feasibility and compare the outcomes of single-incision thoracoscopic surgery using a chest wall pulley for lung excision (PulLE) vs. those of conventional video-assisted thoracic surgery (cVATS) in patients with primary spontaneous pneumothorax (PSP). METHODS: Sixty-nine patients who underwent PulLE (n = 34) or cVATS (n = 35) between January 2009 and December 2013 were enrolled in this study. PulLE was performed as follows. After making a 17- to 25-mm single incision in the 6th intercostal space (6ICS) at the median axillary line, the visceral pleura near the bulla was sutured for traction. The parietal pleura at 3ICS was then sutured from the thoracic cavity to serve as the chest wall pulley and a traction thread was passed through the pulley. By manipulating the traction thread, it was possible to move the lesion to an arbitrary site for excision. The postoperative scar was nearly invisible. RESULTS: The operative time, duration of postoperative drainage, and postoperative hospital stay were equivalent for PulLE vs. cVATS. There was no significant difference in postoperative recurrence rates. CONCLUSIONS: PulLE has cosmetic benefits over cVATS and is easy to perform. We believe our novel procedure has the potential to become the standard operative treatment for PSP.

  May 2015, Surgery today, 45(5) (5), 595 - 9, English, Domestic magazine

  Scientific journal


• A novel dual ex vivo lung perfusion technique improves immediate outcomes in an experimental model of lung transplantation

  Y. Tanaka, K. Noda, K. Isse, K. Tobita, Y. Maniwa, J. K. Bhama, J. D'Cunha, C. A. Bermudez, J. D. Luketich, N. Shigemura

  Blackwell Publishing Ltd, May 2015, American Journal of Transplantation, 15(5) (5), 1219 - 1230, English

  [Refereed]

  Scientific journal


• Postoperative radiotherapy is effective for thymic carcinoma but not for thymoma in stage II and III thymic epithelial tumors: the Japanese Association for Research on the Thymus Database Study.

  Mitsugu Omasa, Hiroshi Date, Takashi Sozu, Tosiya Sato, Kanji Nagai, Kohei Yokoi, Tatsuro Okamoto, Norihiko Ikeda, Fumihiro Tanaka, Yoshimasa Maniwa

  BACKGROUND: The efficacy of postoperative radiotherapy (PORT) for thymic epithelial tumors is still controversial. Using the Japanese Association for Research on the Thymus (JART) database, this study was aimed at clarifying the efficacy of PORT for Masaoka stage II and III thymic carcinoma and thymoma. METHODS: The JART database registered the records of 2835 patients collected from 32 Japanese institutions from 1991 to 2010. Thymic carcinoma and thymoma at stage II or III were extracted. The efficacy of PORT with respect to relapse-free survival (RFS) and overall survival (OS) was evaluated with the Kaplan-Meier method and Cox regression analysis. RESULTS: There were 1265 patients in all: 155 thymic carcinoma cases (12.3%) and 1110 thymoma cases (87.7%). Eight hundred ninety-five (70.8%) were at stage II, and 370 (29.2%) were at stage III. Four hundred three cases (31.9%) underwent PORT. PORT for stage II and III thymic carcinoma was associated with increasing RFS (hazard ratio, 0.48; 95% confidence interval, 0.30-0.78; P = .003) but was not associated with OS (hazard ratio, 0.94; 95% confidence interval, 0.51-1.75; P = .536). PORT for stage II and III thymoma was not associated with RFS or OS (P = .350). A subgroup analysis of stage III thymoma showed no factor associated with the efficacy of PORT. CONCLUSIONS: In this study, PORT did not increase RFS or OS for stage II or III thymoma but increased RFS for stage II and III thymic carcinoma.

  Apr. 2015, Cancer, 121(7) (7), 1008 - 16, English, International magazine

  Scientific journal


• 気道狭窄をきたした食道神経鞘腫の1例

  Tane Shinya, 大隈宏通, Ogawa Hiroyuki, Hokka Daisuke, 田中雄悟, 友野絢子, 金治新悟, 中村哲, 掛地吉弘, Maniwa Yoshimasa

  Apr. 2015, 日本気管食道科学会会報, 66(2号) (2号), s25, Japanese

  [Refereed]

  Scientific journal


• Value of diffusion-weighted MR imaging using various parameters for assessment and characterization of solitary pulmonary nodules

  Hisanobu Koyama, Yoshiharu Ohno, Shinichiro Seki, Mizuho Nishio, Takeshi Yoshikawa, Sumiaki Matsumoto, Yoshimasa Maniwa, Tomoo Itoh, Yoshihiro Nishimura, Kazuro Sugimura

  Mar. 2015, EUROPEAN JOURNAL OF RADIOLOGY, 84(3) (3), 509 - 515, English, International magazine

  [Refereed]

  Scientific journal


• Pleural lavage cytology as an independent prognostic factor in non-small-cell lung cancer patients with stage I disease and adenocarcinoma

  Hokka Daisuke, Uchino K, Tane K, Ogawa H, Tane Shinya, Tanaka Yugo, Tauchi S, Nishio W, Yoshimura M, Maniwa Yoshimasa

  We previously reported that cancer cells may be detected through pleural lavage cytology (PLC). In this study, we sought to re-examine the prognostic significance of the PLC status based on an extended dataset with an additional follow-up period. Pleural lavage following thoracotomy was cytologically examined in 1,317 consecutive patients who were diagnosed with NSCLC between 1987 and 2004 at the Thoracic Surgery Units of Kobe University Graduate School of Medicine and Hyogo Cancer Center. Among the investigated patients, 46 exhibited positive cytological findings. The prognosis of these patients was significantly worse compared to that of patients without positive PLC. Of the 844 pathological stage I patients, 18 had a positive PLC status and their prognosis was significantly worse compared to that of patients with stage I disease without positive PLC. In conclusion, positive PLC findings were associated with a poor prognosis and this finding was significant for patients with stage I disease. These results suggest the need for PLC status evaluation during staging and treatment planning in patients with NSCLC.

  Jan. 2015, Mol Clin Oncol, 3(1) (1), 244 - 248, English, International magazine

  [Refereed]

  Scientific journal


• A Case of Benign Esophageal Schwannoma Causing Life-threatening Tracheal Obstruction

  Ayako Tomono, Tetsu Nakamura, Yasunori Otowa, Tatsuya Imanishi, Yugo Tanaka, Yoshimasa Maniwa, Yoshihiro Kakeji

  2015, ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY, 21(3) (3), 289 - 292, English, Domestic magazine

  [Refereed]

  Scientific journal


• 当科における若年者肺癌の検討

  田村 大介, 立原 素子, 西村 春子, 國政 啓, 徳永 俊太郎, 畠山 由記久, 堀 朱矢, 永野 達也, 大寺 博, 小林 和幸, 船田 泰弘, Sakai Yasuhiro, 大野 良治, 真庭 謙昌, 西村 善博

  Oct. 2014, 肺癌, 54(5号) (5号), 479, Japanese

  Research society


• Clinical significance of the 'not otherwise specified' subtype in candidates for resectable non-small cell lung cancer

  Shinya Tane, Wataru Nishio, Hiroyuki Ogawa, Daisuke Hokka, Kenta Tane, Yugo Tanaka, Shunsuke Tauchi, Kazuya Uchino, Yasuhiro Sakai, Chiho Ohbayashi, Masahiro Yoshimura, Yoshimasa Maniwa

  Sep. 2014, ONCOLOGY LETTERS, 8(3) (3), 1017 - 1024, English, International magazine

  [Refereed]

  Scientific journal


• Sirt1 is a tumor promoter in lung adenocarcinoma

  Xue Chen, Daisuke Hokka, Yoshimasa Maniwa, Chiho Ohbayashi, Tomoo Itoh, Yoshitake Hayashi

  Jul. 2014, ONCOLOGY LETTERS, 8(1) (1), 387 - 393, English, International magazine

  [Refereed]

  Scientific journal


• Diffusion-weighted imaging vs STIR turbo SE imaging: capability for quantitative differentiation of small-cell lung cancer from non-small-cell lung cancer

  H. Koyama, Y. Ohno, M. Nishio, D. Takenaka, T. Yoshikawa, S. Matsumoto, S. Seki, Y. Maniwa, T. Ito, Y. Nishimura, K. Sugimura

  Jun. 2014, BRITISH JOURNAL OF RADIOLOGY, 87(1038) (1038), 20130307, English

  [Refereed]

  Scientific journal


• Diffusion-weighted MR imaging vs. multi-detector row CT: Direct comparison of capability for assessment of management needs for anterior mediastinal solitary tumors

  Shinichiro Seki, Hisanobu Koyama, Yoshiharu Ohno, Mizuho Nishio, Daisuke Takenaka, Yoshimasa Maniwa, Tomoo Itoh, Yoshihiro Nishimura, Kazuro Sugimura

  May 2014, EUROPEAN JOURNAL OF RADIOLOGY, 83(5) (5), 835 - 842, English, International magazine

  [Refereed]

  Scientific journal


• 当院における大腸癌肺転移切除症例の検討

  田中 賢一, 金光 聖哲, 山下 公大, 角 泰雄, 向山 順子, 西 将康, 石田 諒, 秋山 真吾, 瀧口 豪介, 音羽 泰則, 裏川 直樹, 友野 絢子, 高瀬 信尚, 山本 将士, 金治 新悟, 森川 剛志, 今西 達也, 中村 哲, 鈴木 知志, 眞庭 謙昌, 掛地 吉弘

  (一社)日本外科学会, Mar. 2014, 日本外科学会雑誌, 115(臨増2) (臨増2), 822 - 822, Japanese


• Comparison of spontaneous hemopneumothorax and primary spontaneous pneumothorax

  Tsuboshima Kenji, Wakahara Teppei, Matoba Yasumi, Maniwa Yoshimasa

  We performed video-assisted thoracoscopic surgery (VATS) for five patients with spontaneous hemopneumothorax (SHP) in our hospital. In many reports, this disease is noted as hemothorax which requires an emergency operation. We compared five cases of SHP with eighty-five cases of primary spontaneous pneumothorax (PSP). SHP and PSP patients were enrolled in this study from 2009. In four cases of SHP, the aberrant vessel was identified near the bulla. On comparing the two groups, the backgrounds were similar. However, the operative results for SHP and PSP groups were as follows: operation time (94.2±24.0 vs. 73.1±30.5 min, NS), blood loss (896.0±466.3 vs. 5.7±11.2 ml, P<0.05), duration of postoperative drainage (2.0±1.7 vs. 1.5±1.7 days, NS), and postoperative hospital stay (6.2±2.9 vs. 4.0±2.6 days, P<0.05), respectively. The postoperative course was uneventful in all cases. Although the recurrence rate of pneumothorax in both groups was not significant based on the Kaplan-Meier method, SHP patients had a lower recurrence rate than PSP patients (0 vs. 12.1%, respectively). In conclusion, we suggest that SHP is associated with a lower recurrence rate of pneumothorax than PSP.

  The Japanese Association for Chest Surgery, 2014, The Journal of the Japanese Association for Chest Surgery, 28(1) (1), 7 - 12, Japanese


• The efficacy of 320-detector row computed tomography for the assessment of preoperative pulmonary vasculature of candidates for pulmonary segmentectomy

  Shinya Tane, Yoshiharu Ohno, Daisuke Hokka, Hiroyuki Ogawa, Shunsuke Tauchi, Wataru Nishio, Masahiro Yoshimura, Yutaka Okita, Yoshimasa Maniwa

  Dec. 2013, INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY, 17(6) (6), 974 - 980, English

  [Refereed]

  Scientific journal


• 環境からのがんとその対応 アスベストと呼吸器癌 アスベスト関連肺癌に関して

  真庭 謙昌, Sakai Yasuhiro, 内野 和哉, 吉村 雅裕

  Sep. 2013, 日本癌治療学会誌, 48(3号) (3号), 606, Japanese

  Research society


• The role of Necl-5 in the invasive activity of lung adenocarcinoma

  Shinya Tane, Yoshimasa Maniwa, Daisuke Hokka, Shunsuke Tauchi, Wataru Nishio, Yutaka Okita, Masahiro Yoshimura

  Apr. 2013, Experimental and Molecular Pathology, 94(2) (2), 330 - 335, English, International magazine

  [Refereed]

  Scientific journal


• Slug increases sensitivity to tubulin-binding agents via the downregulation of beta III and beta IVa-tubulin in lung cancer cells

  Daisuke Tamura, Tokuzo Arao, Tomoyuki Nagai, Hiroyasu Kaneda, Keiichi Aomatsu, Yoshihiko Fujita, Kazuko Matsumoto, Marco A. De Velasco, Hiroaki Kato, Hidetoshi Hayashi, Shuhei Yoshida, Hideharu Kimura, Yoshimasa Maniwa, Wataru Nishio, Yasuhiro Sakai, Chiho Ohbayashi, Yoshikazu Kotani, Yoshihiro Nishimura, Kazuto Nishio

  Apr. 2013, CANCER MEDICINE, 2(2) (2), 144 - 154, English, International magazine

  [Refereed]

  Scientific journal


• Immunohistochemical studies of pulmonary large cell neuroendocrine carcinoma: A possible association between staining patterns with neuroendocrine markers and tumor response to chemotherapy

  Yugo Tanaka, Hiroyuki Ogawa, Kazuya Uchino, Chiho Ohbayashi, Yoshimasa Maniwa, Wataru Nishio, Atsunori Nakao, Masahiro Yoshimura

  Mar. 2013, JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 145(3) (3), 839 - 846, English, International magazine

  [Refereed]

  Scientific journal


• Primary pediatric endobronchial Ewing sarcoma family of tumors.

  Akira Hayakawa, Satoshi Hirase, Natsuki Matsunoshita, Nobuyuki Yamamoto, Ikuko Kubokawa, Takeshi Mori, Tomoko Yanai, Yoshimasa Maniwa, Kazumoto Iijima

  BACKGROUND: Ewing sarcoma family of tumors is the second most common primary bone tumor of childhood. Extraosseous Ewing sarcoma family of tumors is rare. We present a pediatric case of primary endobronchial Ewing sarcoma family of tumors. CASE REPORT: A 12-year-old boy presented with dyspnea and chest radiography showed right pulmonary atelectasis. Chest computed tomography demonstrated tumor in the right main bronchus. Histopathological examination of the resected tumor demonstrated Ewing sarcoma family of tumors. No other lesions were detected throughout the body and the right main bronchus was thought to be the primary site. As of 1 year and 6 months after further resection of residual tumor followed by chemotherapy and radiotherapy, the patient remains disease-free. CONCLUSIONS: Extraosseous Ewing sarcoma family of tumors arises in soft tissues of the trunk or extremities, but primary endobronchial Ewing sarcoma family of tumors has rarely been reported. Although quite rare, Ewing sarcoma family of tumors should be considered among the differential diagnoses for pediatric bronchial tumor.

  2013, The American journal of case reports, 14, 67 - 9, English, International magazine

  Scientific journal


• Psf3 is a prognostic biomarker in lung adenocarcinoma

  Daisuke Hokka, Yoshimasa Maniwa, Shinya Tane, Wataru Nishio, Masahiro Yoshimura, Yutaka Okita, Chiho Ohbayashi, Yasuhiro Sakai, Xue Chen, Yoshitake Hayashi

  Jan. 2013, LUNG CANCER, 79(1) (1), 77 - 82, English, International magazine

  [Refereed]

  Scientific journal


• The efficacy of 320-detector row computed tomography for the assessment of preoperative pulmonary vasculature of candidates for pulmonary segmentectomy

  Shinya Tane, Yoshiharu Ohno, Daisuke Hokka, Hiroyuki Ogawa, Shunsuke Tauchi, Wataru Nishio, Masahiro Yoshimura, Yutaka Okita, Yoshimasa Maniwa

  Oxford University Press, 2013, Interactive Cardiovascular and Thoracic Surgery, 17(6) (6), 974 - 980, English, International magazine

  [Refereed]

  Scientific journal


• Ewing's sarcoma family of tumors originating in the main bronchus

  Shinya Tane, Waratu Nishio, Shotaro Hashimoto, Daisuke Hokka, Yoshimasa Maniwa, Yasuhiro Funada, Yoshikazu Kotani, Chihoko Hirai, Chiho Ohbayashi, Masahiro Yoshimura

  Nov. 2012, THORACIC CANCER, 3(4) (4), 353 - 356, English, International magazine

  [Refereed]

  Scientific journal


• ALK染色陽性肺腺癌の術前診断の可能性

  Sakai Yasuhiro, 大林 千穂, 中井 登紀子, 大野 良治, 船田 泰弘, 小谷 義一, 西村 善博, 田根 慎也, Tauchi Shunsuke, 真庭 謙昌, 佐久間 淑子, 竹中 大祐, 足立 秀治, 里内 美弥子, 根來 俊一, 小川 裕行, 多根 健太, 内野 和哉, 西尾 渉, 吉村 雅裕

  Oct. 2012, 肺癌, 52(5号) (5号), 810, Japanese

  Research society


• 肺癌患者の遠隔転移・再発診断における全身脂肪抑制造影Quick 3DによるMRIの有用性に関する検討

  Ohno Yoshiharu, Koyama Hisanobu, Kotani Yoshikazu, Maniwa Yoshimasa, Sugimura Kazuro

  (NPO)日本肺癌学会, Oct. 2012, 肺癌, 52(5号) (5号), 605 - 605, Japanese

  Research society


• 当科における傍腫瘍性神経症候群合併小細胞肺癌の臨床的検討

  Tachihara Motoko, Tamura Daisuke, Kasai Daisuke, Funada Yasuhiro, Kotani Yoshikazu, Sakai Yasuhiro, Ohno Yoshiharu, Maniwa Yoshimasa, Nishimura Yoshihiro

  (NPO)日本肺癌学会, Oct. 2012, 肺癌, 52(5号) (5号), 724 - 724, Japanese

  Research society


• Adaptive Iterative Dose Reduction 3Dの低線量CTにおける有用性の検討

  Ohno Yoshiharu, Koyama Hisanobu, Yoshikawa Takeshi, Matsumoto Sumiaki, Kotani Yoshikazu, Maniwa Yoshimasa, Sugimura Kazuro

  (NPO)日本肺癌学会, Oct. 2012, 肺癌, 52(5号) (5号), 609 - 609, Japanese

  [Refereed]

  Symposium


• 肺内転移やリンパ節転移との鑑別が困難であった扁平上皮腺上皮性混合型乳頭腫の1例

  Nakai Tokiko, Sakai Yasuhiro, Ohbayashi Chiho, Nishio Mizuho, Koyama Hisanobu, Ohno Yoshiharu, Tachihara Motoko, Sakashita Akihiro, Kasai Daisuke, Kobayashi Kazuyuki, Funada Yasuhiro, Kotani Yoshikazu, Nishimura Yoshihiro, Hokka Daisuke, Maniwa Yoshimasa, Nishio Wataru

  (NPO)日本肺癌学会, Jun. 2012, 肺癌, 52(3) (3), 353 - 354, Japanese

  Research society


• Expression of nectin 3: Novel prognostic marker of lung adenocarcinoma

  Yoshimasa Maniwa, Wataru Nishio, Yutaka Okita, Masahiro Yoshimura

  May 2012, THORACIC CANCER, 3(2) (2), 175 - 181, English, International magazine

  [Refereed]

  Scientific journal


• Avian-type receptor-binding ability can increase influenza virus pathogenicity in macaques.

  Tokiko Watanabe, Kyoko Shinya, Shinji Watanabe, Masaki Imai, Masato Hatta, Chengjun Li, Ben F Wolter, Gabriele Neumann, Anthony Hanson, Makoto Ozawa, Shinya Yamada, Hirotaka Imai, Saori Sakabe, Ryo Takano, Kiyoko Iwatsuki-Horimoto, Maki Kiso, Mutsumi Ito, Satoshi Fukuyama, Eiryo Kawakami, Takeo Gorai, Heather A Simmons, Daniel Schenkman, Kevin Brunner, Saverio V Capuano 3rd, Jason T Weinfurter, Wataru Nishio, Yoshimasa Maniwa, Tatsuhiko Igarashi, Akiko Makino, Emily A Travanty, Jieru Wang, Anette Kilander, Susanne G Dudman, M Suresh, Robert J Mason, Olav Hungnes, Thomas C Friedrich, Yoshihiro Kawaoka

  The first influenza pandemic of the 21st century was caused by novel H1N1 viruses that emerged in early 2009. An Asp-to-Gly change at position 222 of the receptor-binding protein hemagglutinin (HA) correlates with more-severe infections in humans. The amino acid at position 222 of HA contributes to receptor-binding specificity with Asp (typically found in human influenza viruses) and Gly (typically found in avian and classic H1N1 swine influenza viruses), conferring binding to human- and avian-type receptors, respectively. Here, we asked whether binding to avian-type receptors enhances influenza virus pathogenicity. We tested two 2009 pandemic H1N1 viruses possessing HA-222G (isolated from severe cases) and two viruses that possessed HA-222D. In glycan arrays, viruses possessing HA-222D preferentially bound to human-type receptors, while those encoding HA-222G bound to both avian- and human-type receptors. This difference in receptor binding correlated with efficient infection of viruses possessing HA-222G, compared to those possessing HA-222D, in human lung tissue, including alveolar type II pneumocytes, which express avian-type receptors. In a nonhuman primate model, infection with one of the viruses possessing HA-222G caused lung damage more severe than did infection with a virus encoding HA-222D, although these pathological differences were not observed for the other virus pair with either HA-222G or HA-222D. These data demonstrate that the acquisition of avian-type receptor-binding specificity may result in more-efficient infection of human alveolar type II pneumocytes and thus more-severe lung damage. Collectively, these findings suggest a new mechanism by which influenza viruses may become more pathogenic in mammals, including humans.

  Dec. 2011, Journal of virology, 85(24) (24), 13195 - 203, English, International magazine

  Scientific journal


• A case of huge desmoid tumor expanding from neck to thoracic cavity

  HASHIMOTO Shotaro, NISHIO Wataru, TANE Shinya, MANIWA Yoshimasa, YOSHIMURA Masahiro

  A 34-year-old man showed a gradually increasing mass of the right neck. Chest CT demonstrated a huge tumor expanding from the right neck to the right thoracic cavity. It was diagnosed as a suspected solitary fibrous tumor on tumor biopsy. Surgical resection of the tumor and reconstruction of the right subclavian artery were performed through a modified hemi-clamshell approach. The tumor close to the 5th, 7th, and 8th cervical intervertebral foramina could not be resected because of nerve preservation. Histological and immunohistochemical findings led to the diagnosis of a desmoid tumor. He received adjuvant radiotherapy for the residual tumor. No relapse had been observed as of one year after the surgery.

  The Japanese Association for Chest Surgery, Nov. 2011, The Journal of the Japanese Association for Chest Surgery, 25(7) (7), 732 - 735, Japanese


• N Stage Disease in Patients with Non-Small Cell Lung Cancer: Efficacy of Quantitative and Qualitative Assessment with STIR Turbo Spin-Echo Imaging, Diffusion-weighted MR Imaging, and Fluorodeoxyglucose PET/CT

  Yoshiharu Ohno, Hisanobu Koyama, Takeshi Yoshikawa, Mizuho Nishio, Nobukazu Aoyama, Yumiko Onishi, Daisuke Takenaka, Sumiaki Matsumoto, Yoshimasa Maniwa, Wataru Nishio, Yoshihiro Nishimura, Tomoo Itoh, Kazuro Sugimura

  Nov. 2011, RADIOLOGY, 261(2) (2), 605 - 615, English, International magazine

  [Refereed]

  Scientific journal


• A metabolomic approach to lung cancer

  Suya Hori, Shin Nishiumi, Kazuyuki Kobayashi, Masakazu Shinohara, Yukihisa Hatakeyama, Yoshikazu Kotani, Naoya Hatano, Yoshimasa Maniwa, Wataru Nishio, Takeshi Bamba, Eiichiro Fukusaki, Takeshi Azuma, Tadaomi Takenawa, Yoshihiro Nishimura, Masaru Yoshida

  Nov. 2011, LUNG CANCER, 74(2) (2), 284 - 292, English, International magazine

  [Refereed]

  Scientific journal


• 術前3D-CT肺血管把握における320列Area detector CTの有用性に関する検討

  田根 慎也, 西尾 渉, 法華 大助, 真庭 謙昌, 吉村 雅裕, 大野 良治, 竹中 大祐

  (NPO)日本肺癌学会, Oct. 2011, 肺癌, 51(5) (5), 543 - 543, Japanese


• Non-small cell carcinoma: Comparison of postoperative intra- and extrathoracic recurrence assessment capability of qualitatively and/or quantitatively assessed FDG-PET/CT and standard radiological examinations

  Yumiko Onishi, Yoshiharu Ohno, Hisanobu Koyama, Munenobu Nogami, Daisuke Takenaka, Keiko Matsumoto, Takeshi Yoshikawa, Sumiaki Matsumoto, Yoshimasa Maniwa, Yoshihiro Nishimura, Kazuro Sugimura

  Sep. 2011, EUROPEAN JOURNAL OF RADIOLOGY, 79(3) (3), 473 - 479, English, International magazine

  [Refereed]

  Scientific journal


• Significance of microscopic invasion into hilar peribronchovascular soft tissue in resection specimens of primary non-small cell lung cancer.

  Yasuhiro Sakai, Chiho Ohbayashi, Naoki Kanomata, Kazuyoshi Kajimoto, Toshiko Sakuma, Yoshimasa Maniwa, Wataru Nishio, Shunsuke Tauchi, Kazuya Uchino, Masahiro Yoshimura

  INTRODUCTION: The significance and handling of microscopic invasion of non-small cell lung cancer (NSCLC) into hilar peribronchovascular soft tissue (SHEATH+) have not been defined in the TNM classification by AJCC/UICC; nevertheless, SHEATH+ may be equivalent to spread into the mediastinum. Also, assessment of the margin of peribronchial resection is challenging because of the technical difficulty of inking, and intraoperative and postoperative artifacts. METHODS: Records of 592 consecutive Asian patients with primary NSCLC (excluding adenocarcinoma in situ) who had, without any preoperative therapy, undergone lobectomy, sleeve lobectomy and pneumonectomy were examined. SHEATH+, simply defined as invasion of hilar peribronchovascular soft tissue, without categorizing any invasive patterns, and its significance were statistically analyzed. RESULTS: Forty-four SHEATH+ cases demonstrated significantly advanced TNM stages, and were statistically associated with central occurrence, pN1-3, and vascular invasion, as assessed by logistic regression analysis. No statistically significant differences were observed between TNM stage-adjusted frequency of recurrence and recurrence-free intervals. Kaplan-Meier's estimates of the rate of overall and recurrence-free survival after surgery showed no statistically significant differences between SHEATH+ and SHEATH-. Cox's multivariate analysis suggested SHEATH was not a statistically independent prognostic factor under the TNM classification by AJCC/UICC (7th edition). CONCLUSIONS: SHEATH+ in NSCLC was simply associated with central occurrence and advanced TNM stages. To the best of our knowledge, this is the first report on the significance of SHEATH+ in NSCLC.

  Jul. 2011, Lung cancer (Amsterdam, Netherlands), 73(1) (1), 89 - 95, English, International magazine

  Scientific journal


• Oncogenic phosphatase Wip1 is a novel prognostic marker for lung adenocarcinoma patient survival

  Naoyuki Satoh, Yoshimasa Maniwa, Vladimir P. Bermudez, Kunihiro Nishimura, Wataru Nishio, Masahiro Yoshimura, Yutaka Okita, Chiho Ohbayashi, Jerard Hurwitz, Yoshitake Hayashi

  May 2011, CANCER SCIENCE, 102(5) (5), 1101 - 1106, English, International magazine

  [Refereed]

  Scientific journal


• 肺扁平上皮癌に対する粒子線治療により間質性肺炎の増悪を認めた1例

  冨田 菜々子, 中田 恭介, 櫨木 暢子, 坂下 明大, 小林 和幸, 船田 泰弘, 小谷 義一, 西村 善博, 眞庭 謙昌, 西尾 渉, 竹中 大祐, 大野 良治, 村上 昌雄

  (NPO)日本肺癌学会, Apr. 2011, 肺癌, 51(2) (2), 140 - 141, Japanese


• 空洞形成を呈したrhabdoid形質を伴う肺大細胞癌の1例

  田根 慎也, 橋本 章太郎, 真庭 謙昌, 西尾 渉, 吉村 雅裕, 船田 泰弘, 小谷 義一, 西村 善博, 竹中 大祐, 大野 良治, 神澤 真紀, 原 重雄, 大林 千穂

  (NPO)日本肺癌学会, Apr. 2011, 肺癌, 51(2) (2), 147 - 148, Japanese


• MT1-MMP plays an important role in an invasive activity of malignant pleural mesothelioma cell

  Takefumi Doi, Yoshimasa Maniwa, Yugo Tanaka, Shinya Tane, Shotaro Hashimoto, Yoshiharu Ohno, Wataru Nishio, Yoshihiro Nishimura, Chiho Ohbayashi, Yutaka Okita, Yoshitake Hayashi, Masahiro Yoshimura

  Feb. 2011, EXPERIMENTAL AND MOLECULAR PATHOLOGY, 90(1) (1), 91 - 96, English, International magazine

  [Refereed]

  Scientific journal


• Differentiation of Malignant and Benign Pulmonary Nodules with Quantitative First-Pass 320-Detector Row Perfusion CT versus FDG PET/CT

  Yoshiharu Ohno, Hisanobu Koyama, Keiko Matsumoto, Yumiko Onishi, Daisuke Takenaka, Yasuko Fujisawa, Takeshi Yoshikawa, Minoru Konishi, Yoshimasa Maniwa, Yoshihiro Nishimura, Tomoo Ito, Kazuro Sugimura

  Feb. 2011, RADIOLOGY, 258(2) (2), 599 - 609, English, International magazine

  [Refereed]

  Scientific journal


• A case of chronic expanding hematoma successfully treated with modified Hemi-Clamshell approach

  HOKKA Daisuke, NISHIO Wataru, MANIWA Yoshimasa, YOSHIMURA Masahiro

  A 73-year-old man, who underwent right upper lobectomy and plombage for pulmonary tuberculosis in 1958, was referred to our hospital with a diagnosis of chronic expanding hematoma after complaining of hemoptysis, right axillary swelling, and dyspnea in 2008. Chest CT showed a huge mass in the chest cavity protruding beyond the axilla and causing marked tracheal deviation to the left. He underwent hematoma evacuation and peeling through a modified Hemi-Clamshell approach after transcatheter arterial embolization of the subclavian artery branches. The postoperative course was uneventful. Dyspnea was resolved and he was discharged on the 20th postoperative day. The modified Hemi-Clamshell approach facilitates a wider opening of the sternocostal flap, with safe control of the entire subclavian vessels.

  The Japanese Association for Chest Surgery, Jan. 2011, The Journal of the Japanese Association for Chest Surgery, 25(1) (1), 84 - 86, Japanese


• State-of-the-art radiological techniques improve the assessment of postoperative lung function in patients with non-small cell lung cancer

  Yoshiharu Ohno, Hisanobu Koyama, Munenobu Nogami, Daisuke Takenaka, Yumiko Onishi, Keiko Matsumoto, Sumiaki Matsumoto, Yoshimasa Maniwa, Masahiro Yoshimura, Yoshihiro Nishimura, Kazuro Sugimura

  Jan. 2011, EUROPEAN JOURNAL OF RADIOLOGY, 77(1) (1), 97 - 104, English, International magazine

  [Refereed]

  Scientific journal


• Successful management of descending necrotizing mediastinitis

  Teppei Wakahara, Yugo Tanaka, Yoshimasa Maniwa, Wataru Nishio, Masahiro Yoshimura

  2011, Asian Cardiovascular and Thoracic Annals, 19(3-4) (3-4), 228 - 231, English, International magazine

  [Refereed]

  Scientific journal


• 気管支鏡下細胞診検体を用いたEGFR遺伝子変異検査の有用性の検討

  中田 恭介, 小谷 義一, 櫨木 暢子, 坂下 明大, 小林 和幸, 船田 泰弘, 真庭 謙昌, 西尾 渉, 尾西 由美子, 竹中 大祐, 大野 良治, 伊藤 智雄, 大林 千穂, 西村 善博

  (NPO)日本肺癌学会, Oct. 2010, 肺癌, 50(5) (5), 519 - 519, Japanese


• FDG-PETにて異常集積を認めた混合性胚細胞腫瘍の一例

  尾西 由美子, 大野 良治, 竹中 大祐, 松本 純明, 小谷 義一, 眞庭 謙昌, 西村 善弘, 西尾 渉, 大林 千穂, 杉村 和朗

  (NPO)日本肺癌学会, Oct. 2010, 肺癌, 50(5) (5), 670 - 670, Japanese


• Stiff-Person症候群を合併した浸潤型胸腺腫の1切除例

  橋本 章太郎, 田根 慎也, 真庭 謙昌, 西尾 渉, 吉村 雅裕, 船田 泰弘, 小谷 義一, 西村 善博, 竹中 大祐, 大野 良治, 原 重雄, 伊藤 智雄

  (NPO)日本肺癌学会, Aug. 2010, 肺癌, 50(4) (4), 401 - 401, Japanese


• 腫瘍随伴性小脳変性症を合併した小細胞肺癌の1例

  法華 大助, 西尾 渉, 若原 鉄平, 眞庭 謙昌, 吉村 雅裕

  (NPO)日本呼吸器外科学会, May 2010, 日本呼吸器外科学会雑誌, 24(4) (4), 701 - 703, Japanese


• Overexpression of Necl-5 correlates with unfavorable prognosis in patients with lung adenocarcinoma

  Reiko Nakai, Yoshimasa Maniwa, Yugo Tanaka, Wataru Nishio, Masahiro Yoshimura, Yutaka Okita, Chiho Ohbayashi, Naoyuki Satoh, Hisakazu Ogita, Yoshimi Takai, Yoshitake Hayashi

  May 2010, CANCER SCIENCE, 101(5) (5), 1326 - 1330, English, International magazine

  [Refereed]

  Scientific journal


• Chemosensitivity of lung cancer: Differences between the primary lesion and lymph node metastasis

  Yoshimasa Maniwa, Masahiro Yoshimura, Shotaro Hashimoto, Masahiko Takata, Wataru Nishio

  Mar. 2010, ONCOLOGY LETTERS, 1(2) (2), 345 - 349, English, International magazine

  [Refereed]

  Scientific journal


• 胸腔鏡下に切除した後縦隔発生Castleman病の1例

  橋本 章太郎, 真庭 謙昌, 西尾 渉, 吉村 雅裕, 船田 泰弘, 小谷 義一, 西村 善博, 竹中 大祐, 大野 良治, 上原 慶一郎, 伊藤 智雄

  (NPO)日本肺癌学会, Feb. 2010, 肺癌, 50(1) (1), 97 - 97, Japanese


• Nonsynonymous Single Nucleotide Polymorphisms in DNA Damage Repair Pathways and Lung Cancer Risk

  Yugo Tanaka, Yoshimasa Maniwa, Vladimir P. Bermudez, Takefumi Doi, Wataru Nishio, Chiho Ohbayashi, Yutaka Okita, Jerard Hurwitz, Yoshitake Hayashi, Masahiro Yoshimura

  Feb. 2010, CANCER, 116(4) (4), 896 - 902, English, International magazine

  [Refereed]

  Scientific journal


• Chemosensitivity of Lung Cancer: Differences between Primary Tumor and Lymph Node Metastasis

  Maniwa Yoshimasa

  Jan. 2010, ONCOLOGY LETTERS, Vol. 1, No. 1, pp. 345-349, English

  Scientific journal


• 肺腺癌におけるNecl-5発現の意義

  真庭 謙昌, 橋本 章太郎, 田中 雄悟, 中井 玲子, 西尾 渉, 吉村 雅裕, 小谷 義一, 西村 善博, 竹中 大祐, 大野 良治, 大林 千穂

  (NPO)日本肺癌学会, Oct. 2009, 肺癌, 49(5) (5), 749 - 749, Japanese


• B型肝炎性肝細胞癌にて肝移植後に発症した転移性肺腫瘍に対する1手術例

  橋本 章太郎, 真庭 謙昌, 西尾 渉, 吉村 雅裕, 船田 泰弘, 小谷 義一, 西村 善博, 竹中 大祐, 大野 良治, 大林 千穂, 伊藤 智雄

  (NPO)日本肺癌学会, Aug. 2009, 肺癌, 49(4) (4), 525 - 525, Japanese


• Adenocarcinoma with chondroid stromaの1切除例

  法華 大助, 眞庭 謙昌, 西尾 渉, 船田 泰弘, 小谷 義一, 西村 善博, 竹中 大祐, 大野 良治, 大林 千穂, 伊藤 智雄

  (NPO)日本肺癌学会, Apr. 2009, 肺癌, 49(2) (2), 230 - 230, Japanese


• 断端再発のリスクを考慮した部分切除法(露天掘り法)

  Maniwa Yoshimasa

  Apr. 2009, 日本呼吸器外科学会雑誌, 23巻, 3号, pp. 488-488, Japanese

  International conference proceedings


• 2層化コラーゲンゲル半球法を用いた癌細胞浸潤のメカニズムの研究 肺癌浸潤における癌宿主インターフェイスの役割を中心にして

  Maniwa Yoshimasa

  Mar. 2009, 大和証券ヘルス財団研究業績集, 巻, 32号, pp. 153-158, Japanese

  Scientific journal


• Damage repair pathwayにおけるNon-synonymous SNPと肺腺癌の発生についての検討

  Maniwa Yoshimasa

  Feb. 2009, 日本外科学会雑誌, 110巻, 臨増2, pp. 773-773, Japanese

  International conference proceedings


• Expression and localization of FOXO1 in non-small cell lung cancer

  Takayo Maekawa, Yoshimasa Maniwa, Takefumi Doi, Wataru Nishio, Masahiro Yoshimura, Chiho Ohbayashi, Yoshitake Hayashi, Yutaka Okita

  2009, Oncology Reports, 22(1) (1), 57 - 64, English, International magazine

  [Refereed]

  Scientific journal


• Rad9 is upregulated and plays protective roles in an acute lung injury model

  Masatsugu Yamamoto, Teruaki Nishiuma, Kazuyuki Kobayashi, Yoshimasa Maniwa, Akihiro Sakashita, Yasuhiro Funada, Yoshikazu Kotani, Yoshihiro Nishimura

  Nov. 2008, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 376(3) (3), 590 - 594, English, International magazine

  [Refereed]

  Scientific journal


• DNA damage sensor protein hRad9, a novel molecular target for lung cancer treatment

  Takeshi Yuki, Yoshimasa Maniwa, Takefumi Doi, Kenji Okada, Wataru Nishio, Yoshitake Hayashi, Yutaka Okita

  Nov. 2008, ONCOLOGY REPORTS, 20(5) (5), 1047 - 1052, English, International magazine

  [Refereed]

  Scientific journal


• 腫瘍随伴性小脳変性症(PCD)を合併した小細胞肺癌の1例

  法華 大助, 眞庭 謙昌, 西尾 渉, 船田 泰弘, 小谷 義一, 西村 善博, 神山 久信, 竹中 大祐, 大野 良治, 大林 千穂

  (NPO)日本肺癌学会, Oct. 2008, 肺癌, 48(6) (6), 782 - 782, Japanese


• 非小細胞肺癌患者における全身FDG-PET/CTの術後再発診断能に関する検討

  Takenaka Daisuke, Kotani Yoshikazu, Maniwa Yoshimasa

  (NPO)日本肺癌学会, Oct. 2008, 肺癌, 48巻, 5号, pp. 447-447(5) (5), 447 - 447, Japanese

  International conference proceedings


• 胸部MRIにおける肺腺癌の結節同定能と組織分類の検討 拡散強調像とSTIR像の比較

  Takenaka Daisuke, Kotani Yoshikazu, Maniwa Yoshimasa

  (NPO)日本肺癌学会, Oct. 2008, 肺癌, 48巻, 5号, pp. 583-583(5) (5), 583 - 583, Japanese

  International conference proceedings


• Quantitative and qualitative assessment of non-contrast-enhanced pulmonary MR imaging for management of pulmonary nodules in 161 subjects

  Hisanobu Koyama, Yoshiharu Ohno, Atsushi Kono, Daisuke Takenaka, Yoshimasa Maniwa, Yoshihiro Nishimura, Chiho Ohbayashi, Kazuro Sugimura

  Oct. 2008, EUROPEAN RADIOLOGY, 18(10) (10), 2120 - 2131, English, International magazine

  [Refereed]

  Scientific journal


• Effective Chemotherapy Based on a Chemosensitivity Test for Malignant Pleural Mesothelioma

  Yoshimasa Maniwa, Masahiro Yoshimura, Masahiko Takata, Yoshihiro Nishimura, Yoshiharu Ohno

  Oct. 2008, ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY, 14(5) (5), 319 - 321, English, Domestic magazine

  [Refereed]

  Scientific journal


• Dynamic MRI vs.CT vs.RI 非小細胞肺癌患者の術後肺機能予測能に関する検討

  Takenaka Daisuke, Kotani Yoshikazu, Maniwa Yoshimasa

  (NPO)日本肺癌学会, Oct. 2008, 肺癌, 48巻, 5号, pp. 584-584(5) (5), 584 - 584, Japanese

  International conference proceedings


• Dynamic MRI, dynamic multidetector-row computed tomography (MDCT), and coregistered 2-[fluorine-18]-fluoro-2-deoxy-D-glucose-positron emission tomography (FDG-PET)/CT: Comparative study of capability for management of pulmonary modules

  Yoshiharu Ohno, Hisanobu Koyama, Daisuke Takenaka, Munenobu Nogami, Yoshimasa Maniwa, Yoshihiro Nishimura, Chiho Ohbayashi, Kazuro Sugimura

  Jun. 2008, JOURNAL OF MAGNETIC RESONANCE IMAGING, 27(6) (6), 1284 - 1295, English, International magazine

  [Refereed]

  Scientific journal


• 非小細胞肺癌におけるFOXO1発現の意義

  Maniwa Yoshimasa

  Apr. 2008, 日本呼吸器外科学会雑誌, 22巻, 3号, pp. 452-452, Japanese

  International conference proceedings


• 転移性肺腫瘍に対する粒子線治療後のサルベージ手術

  Maniwa Yoshimasa

  特定非営利活動法人 日本呼吸器外科学会, Apr. 2008, 日本呼吸器外科学会雑誌, 22巻, 3号, pp. 521-521(3) (3), 521 - 521, Japanese

  International conference proceedings


• 最近当科で経験した縦隔炎・縦隔膿瘍の症例

  Ohtsuki Naoki, Maniwa Yoshimasa

  Apr. 2008, 日本気管食道科学会会報, 59巻, 2号, pp. 257-257, Japanese

  International conference proceedings


• 下行性壊死性縦隔炎に対する徹底的な縦隔ドレナージ手術

  Maniwa Yoshimasa

  特定非営利活動法人 日本呼吸器外科学会, Apr. 2008, 日本呼吸器外科学会雑誌, 22巻, 3号, pp. 389-389(3) (3), 389 - 389, Japanese

  International conference proceedings


• The optimal timing to resect pulmonary metastasis

  Maniwa Yoshimasa

  OBJECTIVE: There is no criterion for the timing of surgical resection of pulmonary metastasis. In this study, we investigated the optimal period for pulmonary metastasectomy. METHODS: Between 2000 and 2005, 68 patients underwent complete pulmonary resection of metastatic cancer. Clinical prognostic factor in multivariate analysis was examined. RESULTS: The interval from pulmonary metastasectomy until subsequent recurrence and the interval from detection of pulmonary metastasis until pulmonary metastasectomy were independent prognostic factors. To investigate the relationship between the two characteristics, the 68 patients were divided into two groups according to the interval from lung metastasectomy until subsequent recurrence. Nineteen patients relapsed within 1 year after pulmonary metastasectomy (group A), while 49 patients did not relapse within 1 year (group B). The interval from detection of pulmonary metastasis until pulmonary metastasectomy was significantly shorter in group A than in group B (2.9 months vs 7.1 months, p=0.01). Based on these results, we divided the patients into two different groups and survival was compared. Significantly shorter survival was observed in the patients who underwent pulmonary metastasectomy within 3 months after detection of pulmonary metastasis (group X, n=35) than in those who underwent the surgery beyond 3 months (group Y, n=33). CONCLUSIONS: There were many cases of early relapse after metastasectomy when the interval from detection of pulmonary metastasis until pulmonary metastasectomy was short. Performing metastasectomy at least three months after detection of pulmonary metastasis may significantly improve the prognosis of patients.

  Apr. 2008, European Journal Of Cardio-Thoracic Surgery, Vol. ?, No. ?, pp. ?-?(6) (6), 1135 - 8, English, International magazine

  Scientific journal


• P01-07 非小細胞肺癌におけるFOX01発現の意義(肺癌・バイオマーカー,第25回日本呼吸器外科学会総会)

  真庭 謙昌, 西尾 渉, 若原 鉄平, 田中 雄悟, 前川 貴代, 吉村 雅裕

  特定非営利活動法人 日本呼吸器外科学会, 2008, 日本呼吸器外科学会雑誌, 22(3) (3), 452 - 452, Japanese


• Association of microsatellite instability with thymidylate synthase and dihydropyrimidine dehydrogenase expression in colorectal cancer

  S. Jensen, B. Vainer, M. Kruhoffer, J. Sorensen

  2008, ANNALS OF ONCOLOGY, 19, 94 - 94, English

  International conference proceedings


• 術後補助化学療法としてのCDDP+VNRの安全性と有用性の検討

  櫨木 暢子, 小谷 義一, 船田 泰弘, 西村 善博, 真庭 謙昌, 西尾 渉, 竹中 大祐, 大野 良治, 大林 千穂

  (NPO)日本肺癌学会, Oct. 2007, 肺癌, 47(5) (5), 627 - 627, Japanese


• 肺癌研究 基礎から臨床へ BAC cell浸潤におけるTumor-host interfaceの役割に関しての実験的検討

  Maniwa Yoshimasa

  Oct. 2007, 肺癌, 47巻, 5号, pp. 464-464, Japanese

  International conference proceedings


• Successful treatment of descending necrotizing mediastinitis

  Yugo Tanaka, Yoshimasa Maniwa, Masahiro Yoshimura, Yutaka Okita

  Sep. 2007, General Thoracic and Cardiovascular Surgery, 55(9) (9), 366 - 369, English, Domestic magazine

  [Refereed]

  Scientific journal


• 間質への浸潤傾向を伴った細気管支肺胞上皮癌におけるcancer-stroma interactionに関する実験的検討(In-vitro visualization of cancer-stroma interaction in bronchiolo-alveolar carcinoma (BAG) with invasive component)(英語)

  Maniwa Yoshimasa

  Aug. 2007, 日本癌学会総会記事, 巻, 66回, pp. 330-331, Japanese

  International conference proceedings


• Modification of the Rb-binding domain of replication-competent adenoviral vector enhances cytotoxicity against human esophageal cancers via NF-kappa B activity

  Katsumi Yamada, Hiroaki Moriyama, Hisafumi Yasuda, Kenta Hara, Yoshimasa Maniwa, Hirofumi Hamada, Koichi Yokono, Masao Nagata

  May 2007, HUMAN GENE THERAPY, 18(5) (5), 389 - 400, English, International magazine

  Scientific journal


• Controlled release of basic fibroblast growth factor from gelatin hydrogel sheet improves structural and physiological properties of vein graft in rat

  Tomonori Haraguchi, Kenji Okada, Yasuhiko Tabata, Yoshimasa Maniwa, Yoshitake Hayashi, Yutaka Okita

  Mar. 2007, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 27(3) (3), 548 - 555, English, International magazine

  Scientific journal


• RV-08-3 原発性気管癌に対して緊急手術を施行した2例(気管・気管支形成(3), 第24回日本呼吸器外科学会総会号)

  真庭 謙昌, 吉村 雅裕, 湯木 毅, 田中 雄悟, 上村 亮介, 高田 昌彦, 大北 裕

  特定非営利活動法人 日本呼吸器外科学会, 2007, 日本呼吸器外科学会雑誌, 21(3) (3), 330 - 330, Japanese


• PS-072-1 右主気管支内腔を鋳型状に発育・閉塞した右下葉原発筋上皮細胞癌の1例(肺癌症例10, 第24回日本呼吸器外科学会総会号)

  湯木 毅, 真庭 謙昌, 田中 雄吾, 高田 昌彦, 上村 亮介, 吉村 雅弘, 大林 千穂, 大北 裕

  特定非営利活動法人 日本呼吸器外科学会, 2007, 日本呼吸器外科学会雑誌, 21(3) (3), 460 - 460, Japanese


• Double-layered collagen gel hemisphere for cell invasion assay: Successful visualization and quantification of cell invasion activity

  Masahiko Takata, Yoshimasa Maniwa, Takefumi Doi, Yugo Tanaka, Kenji Okada, Wataru Nishio, Chiho Ohbayashi, Masahiro Yoshimura, Yoshitake Hayashi, Yutaka Okita

  2007, CELL COMMUNICATION AND ADHESION, 14(4) (4), 157 - 167, English, International magazine

  [Refereed]

  Scientific journal


• 肺癌の肺門部気管支血管周囲組織浸潤と断端および予後に関する検討

  Maniwa Yoshimasa

  Nov. 2006, 肺癌, 46巻, 5号, pp. 590-590, Japanese

  International conference proceedings


• 当院における転移性肺腫瘍の検討

  Maniwa Yoshimasa

  (NPO)日本肺癌学会, Nov. 2006, 肺癌, 46巻, 5号, pp. 588-588(5) (5), 588 - 588, Japanese

  International conference proceedings


• 新しいCT,MR技術の肺癌診断への応用 STIR Turbo SE Imaging vs.Co-registered FDG-PET/CT 非小細胞肺癌におけるN因子診断能の検討

  Maniwa Yoshimasa

  (NPO)日本肺癌学会, Nov. 2006, 肺癌, 46巻, 5号, pp. 477-477(5) (5), 477 - 477, Japanese

  International conference proceedings


• 再発肺癌の手術戦略

  Maniwa Yoshimasa

  (NPO)日本肺癌学会, Nov. 2006, 肺癌, 46巻, 5号, pp. 652-652(5) (5), 652 - 652, Japanese

  International conference proceedings


• 原発性肺癌の大動脈浸潤が疑われ人工気胸術(気胸CT)を行った1例

  Maniwa Yoshimasa

  (NPO)日本肺癌学会, Nov. 2006, 肺癌, 46巻, 5号, pp. 598-598(5) (5), 598 - 598, Japanese

  International conference proceedings


• STIR turbo SEを用いた非造影MRIによる肺結節の半定量的良・悪性診断能の検討

  Maniwa Yoshimasa

  (NPO)日本肺癌学会, Nov. 2006, 肺癌, 46巻, 5号, pp. 628-628(5) (5), 628 - 628, Japanese

  International conference proceedings


• 非小細胞肺癌におけるFOXO1を介したアポトーシスに関する実験的検討

  Maniwa Yoshimasa

  Sep. 2006, 日本癌学会総会記事, 巻, 65回, pp. 439-439, Japanese

  International conference proceedings


• DNA damage sensor蛋白質hRad9の肺癌に対する分子標的としての可能性の検討

  Maniwa Yoshimasa

  Sep. 2006, The Japanese Journal of THORACIC AND CARDIOVASCULAR SURGERY, 54巻, Suppl., pp. 479-479, Japanese

  International conference proceedings


• 腫瘍との鑑別を要した良性胸膜病変の2例

  Maniwa Yoshimasa

  (NPO)日本肺癌学会, Aug. 2006, 肺癌, 46巻, 4号, pp. 390-390(4) (4), 390 - 390, Japanese

  International conference proceedings


• HRAD9における肺腺癌に特異的な1塩基多型

  Maniwa Yoshimasa

  (NPO)日本肺癌学会, Aug. 2006, 肺癌, 46巻, 4号, pp. 385-385(4) (4), 385 - 385, Japanese

  International conference proceedings


• 非小細胞肺癌における術後再発症例の外科治療についての検討

  Maniwa Yoshimasa

  May 2006, 日本呼吸器外科学会雑誌, 20巻, 3号, pp. 810-810, Japanese

  International conference proceedings


• 肺切除を回避できた右主気管支断裂・広範欠損に対する1手術例

  Maniwa Yoshimasa

  特定非営利活動法人 日本呼吸器外科学会, May 2006, 日本呼吸器外科学会雑誌, 20巻, 3号, pp. 785-785(3) (3), 785 - 785, Japanese

  International conference proceedings


• 当科における呼吸器外科手術の合併症の予防策 最近5年間の合併症率と共に

  Maniwa Yoshimasa

  特定非営利活動法人 日本呼吸器外科学会, May 2006, 日本呼吸器外科学会雑誌, 20巻, 3号, pp. 861-861(3) (3), 861 - 861, Japanese

  International conference proceedings


• 下行大動脈の全周囲に沿って発育した炎症性悪性線維性組織球腫の1手術例

  Maniwa Yoshimasa

  特定非営利活動法人 日本呼吸器外科学会, May 2006, 日本呼吸器外科学会雑誌, 20巻, 3号, pp. 943-943(3) (3), 943 - 943, Japanese

  International conference proceedings


• 横隔膜縫縮術が奏功した術後横隔神経麻痺の3例

  Maniwa Yoshimasa

  特定非営利活動法人 日本呼吸器外科学会, May 2006, 日本呼吸器外科学会雑誌, 20巻, 3号, pp. 826-826(3) (3), 826 - 826, Japanese

  International conference proceedings


• 経口摂取不能,PS3の肺腺癌再発に対しゲフィチニブ投与により著明なPS改善を認めた1例

  Maniwa Yoshimasa

  (NPO)日本肺癌学会, Apr. 2006, 肺癌, 46巻, 2号, pp. 181-181(2) (2), 181 - 181, Japanese

  International conference proceedings


• 非小細胞肺癌の原発巣と転移リンパ節における抗癌抗感受性の検討

  Maniwa Yoshimasa

  Mar. 2006, 日本外科学会雑誌, 107巻, 臨増2, pp. 582-582, Japanese

  International conference proceedings


• His239Arg SNP of HRAD9 is associated with lung adenocarcinoma

  Y Maniwa, M Yoshimura, VP Bermudez, K Okada, N Kanomata, C Ohbayashi, Y Nishimura, Y Hayashi, J Hurwitz, Y Okita

  Mar. 2006, CANCER, 106(5) (5), 1117 - 1122, English, International magazine

  Scientific journal


• DNA damage repair gene HRAD9における肺腺癌に特異的な1塩基多型

  Maniwa Yoshimasa

  Mar. 2006, 日本外科学会雑誌, 107巻, 臨増2, pp. 533-533, Japanese

  International conference proceedings


• 原発性肺癌におけるHRAD9遺伝子の解析

  MANIWA, Yoshimasa, YOSHIMURA, Masahiro, 高田昌彦, 湯木毅, 内野和哉, 前川貴代, OHBAYASHI, Chiho, HAYASHI, Yoshitake, HurwitzJerard, OKITA, Yutaka

  Nov. 2005, 肺癌, 45巻, 5号, pp.603-603, Japanese

  International conference proceedings


• 悪性胸膜中皮腫の診断と治療

  Maniwa Yoshimasa

  (NPO)日本肺癌学会, Nov. 2005, 肺癌, 45巻, 5号, pp. 657-657(5) (5), 657 - 657, Japanese

  International conference proceedings


• Pleomorphic carcinoma of the lung 9手術例の検討

  Maniwa Yoshimasa

  (NPO)日本肺癌学会, Nov. 2005, 肺癌, 45巻, 5号, pp. 644-644(5) (5), 644 - 644, Japanese

  International conference proceedings


• GGAの経過観察中に第2癌の発見された同時多発肺癌の1例

  Maniwa Yoshimasa

  (NPO)日本肺癌学会, Nov. 2005, 肺癌, 45巻, 5号, pp. 591-591(5) (5), 591 - 591, Japanese

  International conference proceedings


• E1B-deleted adenovirus replicates in p53-deficient lung cancer cells due to the absence of apoptosis

  N Harada, Y Maniwa, M Yoshimura, M Nagata, H Hamada, K Yokono, Y Okita

  Nov. 2005, ONCOLOGY REPORTS, 14(5) (5), 1155 - 1163, English, International magazine

  [Refereed]

  Scientific journal


• 肺癌術後10年以上経過して再発の認められた1例

  Maniwa Yoshimasa

  (NPO)日本肺癌学会, Oct. 2005, 肺癌, 45巻, 6号, pp. 770-770(6) (6), 770 - 770, Japanese

  International conference proceedings


• 肺癌におけるDNA damage sensor蛋白Rad9発現の意義

  MANIWA, Yoshimasa, YOSHIMURA, Masahiro, 湯木毅, OHBAYASHI, Chiho, HAYASHI, Yoshitake, OKITA, Yutaka

  Sep. 2005, 日本癌学会64回総会記事, pp.70-70, Japanese

  International conference proceedings


• 急性縦隔炎の4手術例

  Maniwa Yoshimasa

  Sep. 2005, The Japanese Journal of THORACIC AND CARDIOVASCULAR SURGERY, 53巻, Suppl.II, pp. 309-309, Japanese

  International conference proceedings


• 肺腺癌における細胞周期制御蛋白p21およびその転写活性化因子の発現異常の検討

  Maniwa Yoshimasa

  特定非営利活動法人 日本呼吸器外科学会, May 2005, 日本呼吸器外科学会雑誌, 19巻, 3号, pp. 398-398(3) (3), 398 - 398, Japanese

  International conference proceedings


• 原発性肺癌と心大血管病変を同時に有した症例に対する外科療法の検討

  Maniwa Yoshimasa

  特定非営利活動法人 日本呼吸器外科学会, May 2005, 日本呼吸器外科学会雑誌, 19巻, 3号, pp. 368-368(3) (3), 368 - 368, Japanese

  International conference proceedings


• 当院における同時多発肺癌症例に対する検討

  Maniwa Yoshimasa

  Apr. 2005, 日本外科学会雑誌, 106巻, 臨増, pp. 380-380, Japanese

  International conference proceedings


• 鈍的胸部外傷後の遅発性血胸に対する緊急手術症例

  Maniwa Yoshimasa

  Mar. 2005, The Japanese Journal of THORACIC AND CARDIOVASCULAR SURGERY, 53巻, Suppl.I, pp. 77-77, Japanese

  International conference proceedings


• 転写調節因子による腫瘍の表現形質と悪性度の修飾 細胞周期制御蛋白p21およびその転写活性化因子の発現異常 肺腺癌における表現形質と悪性度の変化

  MANIWA, Yoshimasa, YOSHIMURA, Masahiro, OKITA, Yutaka, KANOMATA, Naoki, OHBAYASHI, Chiho, 埴岡啓介, HurwitzJerard, HAYASHI, Yoshitake

  Mar. 2005, 日本病理学会会誌, 94巻, 1号, pp. 177-177, Japanese

  International conference proceedings


• 縦隔内異物・膿瘍の1手術例

  Maniwa Yoshimasa

  Mar. 2005, The Japanese Journal of THORACIC AND CARDIOVASCULAR SURGERY, 53巻, Suppl.I, pp. 77-77, Japanese

  International conference proceedings


• Pryce III型肺葉内肺分画症の1手術例

  Maniwa Yoshimasa

  Mar. 2005, The Japanese Journal of THORACIC AND CARDIOVASCULAR SURGERY, 53巻, Suppl.I, pp. 50-50, Japanese

  International conference proceedings


• 孤立性肺転移で発見された不顕性甲状腺乳頭癌の1例

  Maniwa Yoshimasa

  (NPO)日本肺癌学会, Feb. 2005, 肺癌, 45巻, 1号, pp. 97-98(1) (1), 97 - 98, Japanese

  International conference proceedings


• Accumulation of hRad9 protein in the nuclei of nonsmall cell lung carcinoma cells

  Y Maniwa, M Yoshimura, VP Bermudez, T Yuki, K Okada, N Kanomata, C Ohbayashi, Y Hayashi, J Hurwitz, Y Okita

  Jan. 2005, CANCER, 103(1) (1), 126 - 132, English, International magazine

  [Refereed]

  Scientific journal


• 非小細胞肺癌の原発巣と転移リンパ節における抗癌剤感受性の検討

  Maniwa Yoshimasa

  日本肺癌学会, Oct. 2004, 肺癌, 44巻, 5号, pp. 657-657(5) (5), 657 - 657, Japanese

  International conference proceedings


• 原発性肺腺癌におけるp53発現異常と細胞分裂能の関連性

  Maniwa Yoshimasa

  (NPO)日本肺癌学会, Oct. 2004, 肺癌, 44巻, 6号, pp. 715-715(6) (6), 715 - 715, Japanese

  International conference proceedings


• 経気管支肺生検と切除肺の組織型,亜型診断の比較検討

  Maniwa Yoshimasa

  (NPO)日本肺癌学会, Oct. 2004, 肺癌, 44巻, 5号, pp. 424-424(5) (5), 424 - 424, Japanese

  International conference proceedings


• STIR Turbo SE MRI vs.FDG-PET 非小細胞肺癌における術前転移リンパ節診断能の比較

  Maniwa Yoshimasa

  (NPO)日本肺癌学会, Oct. 2004, 肺癌, 44巻, 5号, pp. 343-343(5) (5), 343 - 343, Japanese

  International conference proceedings


• 悪性胸膜中皮腫における進展形式の検討とstagingの問題点

  Maniwa Yoshimasa

  Sep. 2004, The Japanese Journal of THORACIC AND CARDIOVASCULAR SURGERY, 52巻, Suppl., pp. 262-262, Japanese

  International conference proceedings


• hRad9蛋白質の生物学的特性と癌細胞における機能

  MANIWA, Yoshimasa, YOSHIMURA, Masahiro, 原田直樹, 高田昌彦, 岩永幸一郎, 湯木毅, 三村剛史, 内野和哉, OKITA, Yutaka, OHBAYASHI, Chiho, ブラディミア・バミューデス, ジェラルド・ハービッツ, HAYASHI, Yoshitake

  Sep. 2004, Cancer Science, 95巻, Suppl., pp. 151-151, Japanese

  International conference proceedings


• Rib cross thoracotomyによる悪性胸膜中皮腫の1手術例

  YOSHIMURA, Masahiro, MANIWA, Yoshimasa, 三村剛史, OHBAYASHI, Chiho, OKITA, Yutaka

  特定非営利活動法人 日本呼吸器外科学会, Apr. 2004, 日本呼吸器外科学会雑誌, 18巻, 3号, pp. 321-321(3) (3), 321 - 321, Japanese

  International conference proceedings


• 同時期に発見された肺癌と心大血管病変に対する外科療法の検討

  YOSHIMURA, Masahiro, MANIWA, Yoshimasa, 中井玲子, 岩永幸一郎, HANAFUSA,Yuji, OZAKI,Nobuchika, OKADA, Kenji, TSUKUBE,Takuro, TSUJI,Yoshihiko, OKITA, Yutaka

  Oct. 2003, The Japanese Journal of THORACIC AND CARDIOVASCULAR SURGERY, 51巻, 増刊, pp. 457-457, Japanese

  International conference proceedings


• 原発性肺癌におけるDNA damage sensor蛋白質発現の分析

  MANIWA, Yoshimasa, YOSHIMURA, Masahiro, 原田直樹, 高田昌彦, 岩永幸一郎, OHBAYASHI, Chiho, OKITA, Yutaka

  Oct. 2003, 肺癌, 43巻, 5号, pp. 509-509, Japanese

  International conference proceedings


• The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA

  VP Bermudez, Y Maniwa, Tappin, I, K Ozato, K Yokomori, J Hurwitz

  Sep. 2003, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 100(18) (18), 10237 - 10242, English, International magazine

  [Refereed]

  Scientific journal


• 原発性肺肉腫の二手術例

  田中亜紀子, YOSHIMURA, Masahiro, 中井玲子, 田中雄悟, 岩永幸一郎, 原田直樹, MANIWA, Yoshimasa, OHBAYASHI, Chiho, OKITA, Yutaka

  特定非営利活動法人 日本呼吸器外科学会, Apr. 2003, 日本呼吸器外科学会雑誌, 17巻, 3号, pp. 437-437(3) (3), 437 - 437, Japanese

  International conference proceedings


• Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro

  VP Bermudez, LA Lindsey-Boltz, AJ Cesare, Y Maniwa, JD Griffith, J Hurwitz, A Sancar

  Feb. 2003, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 100(4) (4), 1633 - 1638, English, International magazine

  [Refereed]

  Scientific journal


• 壊死性降下性縦隔炎の2手術例

  田中 雄悟, 吉村 雅裕, 中井 玲子, 田中 亜紀子, 岩永 幸一郎, 原田 直樹, 真庭 謙昌, 丹生 健一, 大北 裕

  特定非営利活動法人 日本呼吸器外科学会, 2003, 日本呼吸器外科学会雑誌, 17(3) (3), 408 - 408, Japanese


• AFP上昇を認め,未熟型奇形腫とyolk sac tumor(YST)成分の混在が疑われた前縦隔腫瘍の1例

  渡辺 裕一, 竹中 大祐, 大野 良治, 足立 秀治, 杉村 和朗, 真庭 謙昌, 吉村 雅弘, 大北 裕, 大林 千穂

  (NPO)日本肺癌学会, Apr. 2001, 肺癌, 41(2) (2), 173 - 173, Japanese


• 呼吸同期turbo STIR法による肺癌の縦隔・肺門リンパ節転移に関する検討 信号強度による定量的評価の試み

  竹中 大祐, 大野 良治, 渡邊 裕一, 小島 芳夫, 足立 秀治, 杉村 和朗, 真庭 謙昌, 山本 英博, 大北 裕, 大林 千穂

  (NPO)日本肺癌学会, Sep. 2000, 肺癌, 40(5) (5), 413 - 413, Japanese


• 末梢発生小型肺癌に対する軟性鏡によるアプローチ(一穴法)

  山本 英博, 大北 裕, 真庭 謙昌, 竹中 大祐, 大野 良治, 小島 芳夫, 足立 秀治

  (NPO)日本肺癌学会, Sep. 2000, 肺癌, 40(5) (5), 464 - 464, Japanese


• 軟性鏡による1穴法の肺腫瘤切除例の検討

  山本 英博, 岡田 昌義, 大野 良治, 真庭 謙昌, 本山 新, 糸氏 英一郎, 足立 秀治

  (NPO)日本肺癌学会, Sep. 1999, 肺癌, 39(5) (5), 581 - 581, Japanese

• Malignant mesothelioma in situ diagnosed by methylthioadenosine phosphorylase loss and homozygous deletion of CDKN2A: a case report.

  Kazuhiro Minami, Naoe Jimbo, Yugo Tanaka, Daisuke Hokka, Yoshifumi Miyamoto, Tomoo Itoh, Yoshimasa Maniwa

  Malignant pleural mesothelioma (MPM), associated with unfavorable outcomes, is closely associated with asbestos exposure. Early detection and treatment are critical to prolong survival of patients with MPM because of the rapid progression and resistance to treatment. The recently defined malignant mesothelioma in situ (MIS) has been gaining increasing attention with advances in genome-based methods including fluorescence in situ hybridization (FISH) as well as immunohistochemistry. We herein report the case of a MIS in a 73-year-old male with a history of asbestos exposure presenting with massive pleural effusion in the right thoracic cavity. Video-assisted thoracoscopic surgery with pleural biopsy of the right side revealed a single layer of atypical mesothelial cells without invasive lesions by hematoxylin and eosin staining. However, these mesothelial cells exhibited a loss of methylthioadenosine phosphorylase (MTAP) by immunohistochemistry and homozygous deletion of CDKN2A (p16) by FISH, leading to the diagnosis of MIS.

  Mar. 2020, Virchows Archiv : an international journal of pathology, 476(3) (3), 469 - 473, English, International magazine


• A case of leiomyosarcoma originating from a bronchogenic cyst: A case report.

  Kenji Kimura, Hiroyuki Ogawa, Naoe Jimbo, Daisuke Hokka, Yugo Tanaka, Yoshimasa Maniwa

  Mediastinal leiomyosarcoma is an aggressive tumor that primarily occurs in the posterior mediastinum. A bronchogenic cyst is a benign lesion that often develops in the mediastinum close to the thoracic trachea and has been reported to be the origin of certain malignancies. The present study reports an extremely rare case of an anterior mediastinal leiomyosarcoma that was considered to have originated from a bronchogenic cyst. An 82-year-old woman complained of chest pain, presenting an abnormal 70 mm mass shadow in the anterior mediastinum of a chest CT scan. Mediastinal tumor resection was performed and the tumor was diagnosed as a leiomyosarcoma. As the tumor was located adjacent to a bronchogenic cyst, it was considered to have originated from the remnant tissue of the cyst. Recurrent lesions were noted in the right lower lobe on CT scan 24 months after surgery.

  Mar. 2020, Molecular and clinical oncology, 12(3) (3), 244 - 246, English, International magazine


• 複数回手術を含んだ集学的治療により長期生存を得ている再発胸腺腫の1例

  法華大助, 法華大助, 井澤良介, 大橋千裕, 中村速, 黒田紗菜恵, 酒井秀都, 内田孝宏, 木村賢司, 岡本武士, 清水奈保子, 土井健史, 田中雄悟, 眞庭謙昌

  2020, 日本胸腺研究会プログラム・抄録集(Web), 39th


• 術後合併症に苦慮した巨大肺嚢胞の1例

  酒井秀都, 田中雄悟, 井澤良介, 大橋千裕, 黒田紗奈恵, 中村速, 内田孝宏, 三浦賢仁, 木村賢司, 清水奈保子, 岡本武士, 土井健史, 法華大助, 眞庭謙昌

  2020, 日本呼吸器外科学会総会(Web), 37th


• 当院における多発肺癌に対する手術症例の検討

  木村賢司, 田中雄悟, 大橋千裕, 井澤良介, 黒田紗菜恵, 中村速, 酒井秀都, 内田孝宏, 岡本武士, 土井健史, 法華大助, 眞庭謙昌

  2020, 日本呼吸器外科学会総会(Web), 37th


• 高齢者気胸手術におけるダブルレイヤー法の有用性の検討

  法華大助, 田中雄悟, 岡本武士, 清水奈保子, 土井健史, 眞庭謙昌

  2020, 日本気胸・嚢胞性肺疾患学会雑誌, 20(1) (1)


• 外科的切除が奏功した肺原発のACTH産生非定型カルチノイドの1手術例

  大橋千裕, 土井健史, 井澤良介, 黒田紗菜恵, 中村速, 酒井秀都, 内田孝宏, 三浦賢仁, 南和宏, 木村賢司, 岡本武士, 清水奈保子, 法華大助, 田中雄悟, 眞庭謙昌

  2020, 肺癌(Web), 60(2) (2)


• Severe congestion of a resected lung during surgery for lung cancer requiring total vertebrectomy

  黒田紗菜恵, 田中雄悟, 三浦賢仁, 土井健史, 法華大助, 眞庭謙昌

  2020, 日本呼吸器外科学会雑誌(Web), 34(7) (7)


• 切除困難な局所進行胸腺腫に対する外科切除症例についての検討

  田中雄悟, 大橋千裕, 井澤良介, 黒田紗菜恵, 中村速, 酒井秀都, 内田孝宏, 三浦賢仁, 木村賢司, 岡本武士, 清水奈保子, 土井健史, 法華大助, 眞庭謙昌

  2020, 日本呼吸器外科学会総会(Web), 37th


• 異常血管を認めない肺葉外肺分画症の1切除例

  黒田紗菜恵, 田中雄悟, 井澤良介, 大橋千裕, 中村速, 酒井秀都, 内田孝宏, 木村賢司, 岡本武士, 清水奈保子, 土井健史, 法華大助, 眞庭謙昌

  2020, 日本呼吸器外科学会総会(Web), 37th


• Malignant mesothelioma in situと考えられた1例

  南和宏, 田中雄悟, 法華大助, 神保直江, 宮本良文, 眞庭謙昌

  2020, 日本呼吸器外科学会総会(Web), 37th


• 周囲臓器への広範囲浸潤を伴う重症筋無力症合併胸腺腫に対する治療方針の検討

  土井健史, 田中雄悟, 松村考, 中尾聡一郎, 福岡有紗, 井澤良介, 大橋千裕, 黒田紗菜恵, 酒井秀都, 内田孝宏, 三浦賢仁, 大隈宏通, 岡本武士, 清水奈保子, 法華大助, 眞庭謙昌

  2020, 日本胸部外科学会定期学術集会(Web), 73rd


• 胸腔鏡下手術の安全性向上を目指した臨床研究

  清水奈保子, 田中雄悟, 松村考, 福岡有紗, 中尾聡一郎, 井澤良介, 大橋千裕, 酒井秀都, 内田孝宏, 大隈宏通, 土井健史, 法華大助, 眞庭謙昌

  2020, 日本胸部外科学会定期学術集会(Web), 73rd


• 肺高悪性度神経内分泌癌の予後バイオマーカーとしてのインスリノーマ関連タンパク質1の検討

  南和宏, 田中雄悟, 岡本武士, 清水奈保子, 土井健史, 法華大助, 眞庭謙昌

  2020, 日本胸部外科学会定期学術集会(Web), 73rd


• ロボット支援下肺葉切除術におけるリンパ節郭清手技の有用性

  法華大助, 中村速, 黒田紗菜恵, 酒井秀都, 内田孝宏, 清水奈保子, 土井健史, 田中雄悟, 眞庭謙昌

  2020, 日本胸部外科学会定期学術集会(Web), 73rd


• 長期経過観察された術後横隔膜弛緩症に対し横隔膜縫縮術を行った1例

  大橋千裕, 内田孝宏, 井澤良介, 黒田紗菜恵, 中村速, 酒井秀都, 三浦賢仁, 木村賢司, 岡本武士, 清水奈保子, 土井健史, 法華大助, 田中雄悟, 眞庭謙昌

  2020, 日本呼吸器外科学会総会(Web), 37th


• 中縦隔に発生した気道狭窄を伴う動静脈奇形に対する1手術例

  土井健史, 田中雄悟, 井澤良介, 大橋千裕, 黒田紗菜恵, 中村速, 酒井秀都, 内田孝宏, 三浦賢仁, 南和宏, 木村賢司, 岡本武士, 清水奈保子, 法華大助, 眞庭謙昌

  2020, 日本呼吸器外科学会総会(Web), 37th


• 手術及び残存病変への陽子線治療にて長期生存が得られた縦隔原発骨外性骨肉腫の1例

  清水奈保子, 田中雄悟, 井澤良介, 大橋千裕, 中村速, 黒田紗菜恵, 酒井秀都, 内田孝宏, 土井健史, 法華大助, 眞庭謙昌

  2020, 日本呼吸器外科学会総会(Web), 37th


• 術後胸骨離開に対する胸骨固定用チタンプレートを用いた再固定手術

  法華大助, 法華大助, 井澤良介, 大橋千裕, 中村速, 黒田紗菜恵, 酒井秀都, 内田孝宏, 木村賢司, 岡本武士, 清水奈保子, 土井健史, 田中雄悟, 眞庭謙昌

  2020, 日本呼吸器外科学会総会(Web), 37th


• 胸腺胸腺腫摘出後にGood症候群と診断した1例

  井澤良介, 井澤良介, 法華大助, 法華大助, 大橋千裕, 中村速, 黒田紗奈恵, 酒井秀都, 内田孝宏, 木村賢司, 岡本武士, 清水奈保子, 土井健史, 田中雄悟, 宮本良文, 眞庭謙昌

  2020, 日本呼吸器外科学会総会(Web), 37th


• Neuroendocrine marker staining pattern categorization of small-sized pulmonary large cell neuroendocrine carcinoma.

  Kazuhiro Minami, Yugo Tanaka, Hiroyuki Ogawa, Naoe Jimbo, Wataru Nishio, Masahiro Yoshimura, Tomoo Itoh, Yoshimasa Maniwa

  BACKGROUND: The aim of this study was to identify subgroups with good or bad prognosis in patients with pulmonary large cell neuroendocrine carcinoma (LCNEC) based on immunostaining patterns with neuroendocrine markers and compare them with small cell lung carcinoma (SCLC). METHODS: From January 2001 to December 2017, of all patients with resected LCNEC and SCLC, we selected patients whose pathological tumor sizes were ≤30 mm in diameter (defined as small-sized tumors) and who underwent complete resection with lymphadenectomy. We classified patients with small-sized LCNEC (sLCNEC) into two subgroups based on immunostaining patterns with three neuroendocrine markers (chromogranin A, synaptophysin, and NCAM) and compared them to small-sized SCLC (sSCLC). RESULTS: A total of 48 patients with sLCNEC and 39 patients with sSCLC were enrolled. Of 48 patients with sLCNEC, 21 were categorized as the small-sized triple-positive group (sTP), whose patients were positive for the three neuroendocrine markers, and 27 patients were categorized as the small-sized nontriple-positive group (sNTP), whose patients were not positive for all three neuroendocrine markers. The percentage of lymph node metastasis was significantly lower in sNTP than in sTP and sSCLC. There was no significant difference in overall survival, but recurrence-free survival (RFS) and tumor-specific survival (TSS) were significantly poorer in sTP and sSCLC than in sNTP. Multivariate analysis revealed sTP and sSCLC were independent prognostic factors for poorer RFS and TSS than those of sNTP. CONCLUSIONS: The sNTP subgroup had a good prognosis and the sTP subgroup a poor prognosis. There were some similarities in clinicopathological features between sTP and sSCLC.

  Nov. 2019, Thoracic cancer, 10(11) (11), 2152 - 2160, English, International magazine


• アミロイド沈着により著明な石灰化を呈した前縦隔リンパ腫の1例

  松尾 秀俊, 岸田 雄治, 神田 知紀, 神保 直江, 伊藤 智雄, 田中 雄悟, 眞庭 謙昌, 村上 卓道

  (公社)日本医学放射線学会, Sep. 2019, 日本医学放射線学会秋季臨床大会抄録集, 55回, S550 - S550, Japanese


• 新規採用初期臨床研修医を対象とした基本的技術トレーニング研修の取り組み

  木村 真希, 坂口 一彦, 伊藤 智雄, 眞庭 謙昌, 小林 成美, 小林 和幸, 宮良 高雄, 八幡 眞理子, 大路 剛, 今西 孝充, 横山 朋大, 加藤 博史, 大原 彰子, ウィリアムソン 彰子, 河野 誠司

  (一社)日本医学教育学会, Jul. 2019, 医学教育, 50(Suppl.) (Suppl.), 154 - 154, Japanese


• 当院における胸腺癌手術症例の臨床的検討

  松本学, 田中雄悟, 黒田紗菜恵, 中村速, 光井卓, 酒井秀都, 南和宏, 木村賢司, 岡本武士, 清水奈保子, 土井健史, 法華大助, 眞庭謙昌

  2019, 日本呼吸器外科学会総会(Web), 36th


• 横隔膜の修復が必要であった再発胸腺腫の1切除例

  黒田紗菜恵, 清水奈保子, 中村速, 松本学, 光井卓, 酒井秀都, 木村賢司, 岡本武士, 土井健史, 法華大助, 田中雄悟, 眞庭謙昌

  2019, 日本呼吸器外科学会総会(Web), 36th


• 縦隔発生肉腫に対する外科治療の検討

  田中雄悟, 黒田紗菜恵, 中村速, 松本学, 光井卓, 酒井秀都, 南和宏, 木村賢司, 岡本武士, 清水奈保子, 土井健史, 法華大助, 眞庭謙昌, 北村嘉隆, 西尾渉, 吉村雅裕

  2019, 日本呼吸器外科学会総会(Web), 36th


• 3D斜視内視鏡を用いた完全鏡視下左上葉スリーブ切除術の1例

  中村速, 清水奈保子, 田中雄悟, 黒田紗菜恵, 松本学, 光井卓, 酒井秀都, 南和宏, 木村賢司, 岡本武士, 土井健史, 法華大助, 眞庭謙昌

  2019, 気管支学, 41


• 胸腔鏡困難症例に対する当科での取り組み

  田中雄悟, 大橋千裕, 井澤良介, 黒田紗菜恵, 中村速, 酒井秀都, 内田孝宏, 三浦賢仁, 南和宏, 木村賢司, 岡本武士, 清水奈保子, 土井健史, 法華大助, 眞庭謙昌

  2019, 日本内視鏡外科学会総会(Web), 32nd


• 反回神経分岐部中枢側発生の迷走神経鞘腫に対する胸腔鏡下被膜内核出術

  法華大助, 法華大助, 酒井秀都, 木村賢司, 土井健史, 田中雄悟, 真庭謙昌

  2019, 日本内視鏡外科学会総会(Web), 32nd


• 原発性肺癌に対する胸腔鏡手術における開胸移行例の検討

  木村賢司, 田中雄悟, 酒井秀都, 土井健史, 法華大助, 真庭謙昌

  2019, 日本内視鏡外科学会総会(Web), 32nd


• 術前抗血小板薬内服症例に対する胸腔鏡下手術についての検討

  酒井秀都, 田中雄悟, 木村賢司, 土井健史, 法華大助, 真庭謙昌

  2019, 日本内視鏡外科学会総会(Web), 32nd


• 胃癌術後10年で初再発が確認された右上葉限局の転移移性肺腫瘍の1切除例

  大橋千裕, 土井健史, 黒田紗菜恵, 中村速, 松本学, 光井卓, 酒井秀都, 南和宏, 木村賢司, 岡本武士, 清水奈保子, 法華大助, 田中雄悟, 眞庭謙昌

  2019, 日本肺癌学会総会号, 60th


• 椎体浸潤肺癌に対する椎体合併右上葉切除術の1例

  黒田紗菜恵, 田中雄悟, 井澤良介, 大橋千裕, 中村速, 酒井秀都, 内田孝宏, 清水奈保子, 土井健史, 法華大助, 眞庭謙昌

  2019, 日本肺癌学会総会号, 60th


• 重症筋無力症合併胸腺腫に対する手術症例の検討

  南和宏, 田中雄悟, 岡本武士, 清水奈保子, 土井健史, 法華大助, 神保直江, 眞庭謙昌

  2019, 日本胸部外科学会定期学術集会(Web), 72nd


• 増大傾向を認めた後縦隔発生ミュラー管嚢胞の1切除例

  中村速, 中村速, 法華大助, 法華大助, 井澤良介, 大橋千裕, 黒田紗菜恵, 酒井秀都, 内田孝宏, 三浦賢仁, 南和宏, 木村賢司, 岡本武士, 清水奈保子, 土井健史, 田中雄悟, 眞庭謙昌

  2019, 日本肺癌学会総会号, 60th


• 術前にステロイドパルス療法を行い完全切除が可能となった胸腺腫の1例

  土井健史, 田中雄悟, 井澤良介, 大橋千裕, 黒田紗菜恵, 中村速, 酒井秀都, 内田孝宏, 三浦賢仁, 南和宏, 木村賢司, 岡本武士, 清水奈保子, 法華大助, 眞庭謙昌

  2019, 日本肺癌学会総会号, 60th


• 肺動脈内膜摘除術および右肺全摘を要した肺動脈原発血管肉腫の1切除例

  松本学, 清水奈保子, 黒田紗菜恵, 中村速, 光井卓, 酒井秀都, 南和宏, 木村賢司, 岡本武士, 土井健史, 法華大助, 田中雄悟, 眞庭謙昌

  2019, 肺癌(Web), 59(2) (2)


• in situ主体の悪性胸膜中皮腫が疑われた1例

  南和宏, 田中雄悟, 中村速, 黒田紗菜恵, 松本学, 光井卓, 酒井秀都, 木村賢司, 岡本武士, 清水奈保子, 土井健史, 法華大助, 眞庭謙昌, 神保直江, 宮本良文

  2019, 肺癌(Web), 59(2) (2)


• 悪性腫瘍との鑑別を要した肺ヒストプラズマ症の一例

  光井卓, Shimizu Nahoko, 松本学, 松本高典, 西岡祐希, 金泰雄, 南和宏, 木村賢司, 小川裕行, Hokka Daisuke, Tanaka Yugo, 大路剛, Iwata Kentaro, Maniwa Yoshimasa

  Apr. 2018, 日本呼吸器外科学会雑誌, 32(3号) (3号), P32 - 3, Japanese

  [Refereed]

  Meeting report


• 原発性肺癌に対する胸腔鏡下肺葉切除術の有用性に関する研究

  眞庭 謙昌, 田根 慎也, 大隈 宏通, 小川 裕行, 法華 大助, 多根 健太, 田中 雄悟, 内野 和哉, 西尾 渉, 吉村 雅裕

  兵庫県外科医会, 2017, 兵庫県外科医会会誌 = Journal of Hyogo Surgical Association, 51, 3 - 16, Japanese


• In vitro Construction of Lung Cancer Organoids from Induced Lung Cancer Stem Like Cells

  Hiroyuki Ogawa, Takashi Aoi, Nahoko Shimizu, Daisuke Hokka, Yugo Tanaka, Michiyo Koyanagi-Aoi, Yoshimasa Maniwa

  Jan. 2017, JOURNAL OF THORACIC ONCOLOGY, 12(1) (1), S1153 - S1153, English

  Summary international conference


• 気胸に対する鏡視下手術

  真庭 謙昌

  オプトロニクス社, Jan. 2016, Medical photonics, 2016(1) (1), 19 - 24,7, Japanese


• 自然気胸に対するx Gateの使用経験

  Hokka Daisuke, 内田孝宏, 大隈宏通, 奥田祐亮, 清水奈保子, Ogawa Hiroyuki, Tane Shinya, 田中雄悟, Maniwa Yoshimasa

  Jul. 2015, 日本気胸・嚢胞性肺疾患学会雑誌, 15(1号) (1号), 61, Japanese

  [Refereed]

  Meeting report


• 【呼吸器外科の手術看護パーフェクトマニュアル】 (第2章)実践編 術式別の術中看護マニュアル 気胸に対する手術

  Maniwa Yoshimasa

  Mar. 2015, オペナーシング, 臨時増刊, 189 - 198, Japanese

  Introduction scientific journal


• 肺癌手術材料で腫瘍との鑑別が求められる粘液化生を認めた2例

  糸口 直江, 大谷 恭子, 酒井 康裕, 伊藤 智雄, 西村 春佳, 畠山 由記久, 堀 朱矢, 永野 達也, 中田 恭介, 新家 治子, 櫨木 暢子, 田村 大介, 立原 素子, 大寺 博, 小林 和幸, 船田 泰弘, 西村 善博, 大隈 宏通, 法華 大介, 田根 慎也, 田中 雄悟, 眞庭 謙昌, 西尾 瑞穂, 神山 久信, 大野 良治

  (NPO)日本肺癌学会, Feb. 2015, 肺癌, 55(1) (1), 78 - 78, Japanese


• 肺癌手術材料で腫瘍との鑑別が求められる粘液化生を認めた2例

  糸口直江, 大谷恭子, 酒井康裕, 伊藤智雄, 西村春佳, 畠山由記久, 堀朱矢, 永野達也, 中田恭介, 新家治子, 櫨木暢子, 田村大介, 立原素子, 大寺博, 小林和幸, 船田泰弘, 西村善博, 大隈宏通, 法華大介, 田根慎也, 田中雄悟, 眞庭謙昌, 西尾瑞穂, 神山久信, 大野良治

  (NPO)日本肺癌学会, Feb. 2015, 肺癌(Web), 55(1) (1), 78(J‐STAGE) - 78, Japanese


• 骨肉腫‐転移性肺腫瘍に対する外科的治療の役割と補助療法‐

  AKISUE TOSHIHIRO, 真庭 謙昌

  2015, 日本胸部臨床, 74, 960 - 968, Japanese

  [Invited]

  Introduction scientific journal


• まい・てくにっく 肺靱帯切離と#9郭清のポイント

  Maniwa Yoshimasa

  Dec. 2014, 胸部外科, 67(13) (13), 1133, Japanese

  Introduction scientific journal


• Pulmonary large cell neuroendocrine carcinoma exhibiting extensive pagetoid spread in the bronchial epithelium: A case report

  Hiroyuki Ogawa, Yugo Tanaka, Yu-Ichiro Koma, Daisuke Hokka, Shinya Tane, Shunsuke Tauchi, Kazuya Uchino, Masahiro Yoshimura, Yoshimasa Maniwa

  Dec. 2014, ONCOLOGY LETTERS, 8(6) (6), 2621 - 2623, English, International magazine

  [Refereed]


• 前縦隔に認められたSolitary Fibrous Tumorの1例

  神山 久信, 関 紳一郎, 西尾 瑞穂, 松本 純明, 真庭 謙昌, 酒井 康裕, 伊藤 智雄, 大野 良治, 杉村 和朗

  (公社)日本医学放射線学会, Sep. 2014, 日本医学放射線学会秋季臨床大会抄録集, 50回, S706 - S707, Japanese


• 腸型が疑われた肺腺癌の1例

  大谷 恭子, 酒井 康裕, 伊藤 智雄, 寺下 智美, 三輪 菜々子, 徳永 俊太郎, 畠山 由記久, 河 良崇, 永野 達也, 新家 治子, 堀 朱矢, 櫨木 暢子, 田村 大介, 立原 素子, 大寺 博, 小林 和幸, 船田 泰弘, 西村 善博, 小川 裕行, 法華 大助, 田根 慎也, 田中 雄悟, 眞庭 謙昌, 西尾 瑞穂, 神山 久信, 大野 良治

  (NPO)日本肺癌学会, Aug. 2014, 肺癌, 54(4) (4), 243 - 243, Japanese


• 画像診断Q&A

  田中 雄悟, 眞庭 謙昌

  南江堂, Jul. 2014, 胸部外科 = The Japanese journal of thoracic surgery, 67(7) (7), 562 - 565, Japanese


• 【ナースのためのパーフェクトガイド 呼吸器外科の術前術後ケア】 (第3章)呼吸器外科・看護の各論 疾患 嚢胞性疾患・気胸

  Maniwa Yoshimasa

  Apr. 2014, 呼吸器ケア, 臨時増刊(217) (217), 217 - 227, Japanese

  Introduction scientific journal


• OP-067-7 NOS(not otherwise specified)の臨床的意義について(OP-067 肺 診断,一般演題,第114回日本外科学会定期学術集会)

  田根 慎也, 小川 裕行, 法華 大助, 多根 健太, 田中 雄悟, 田内 俊輔, 内野 和哉, 西尾 渉, 吉村 雅裕, 眞庭 謙昌

  一般社団法人日本外科学会, 05 Mar. 2014, 日本外科学会雑誌, 115(2) (2), 435 - 435, Japanese


• WS-9-3 肺神経内分泌癌に対する手術症例の臨床的検討(WS-9 ワークショップ(9)本邦におけるNET治療の実態-診療ガイドラインへの展開-,第114回日本外科学会定期学術集会)

  小川 裕行, 田中 雄悟, 田根 慎也, 法華 大助, 田内 俊輔, 奥田 祐亮, 清水 奈保子, 多根 健太, 内野 和哉, 西尾 渉, 吉村 雅裕, 眞庭 謙昌

  一般社団法人日本外科学会, 05 Mar. 2014, 日本外科学会雑誌, 115(2) (2), 224 - 224, Japanese


• PS-032-8 高齢者非小細胞肺癌に対する外科治療成績(PS-032 肺 高齢者-2・その他,ポスターセッション,第114回日本外科学会定期学術集会)

  田内 俊輔, 小川 裕行, 田根 慎也, 法華 大助, 田中 雄悟, 眞庭 謙昌

  一般社団法人日本外科学会, 05 Mar. 2014, 日本外科学会雑誌, 115(2) (2), 639 - 639, Japanese


• PS-124-4 当院における大腸癌肺転移切除症例の検討(PS-124 大腸 転移-2,ポスターセッション,第114回日本外科学会定期学術集会)

  田中 賢一, 金光 聖哲, 山下 公大, 角 泰雄, 向山 順子, 西 将康, 石田 諒, 秋山 真吾, 瀧口 豪介, 音羽 泰則, 裏川 直樹, 友野 絢子, 高瀬 信尚, 山本 将士, 金治 新悟, 森川 剛志, 今西 達也, 中村 哲, 鈴木 知志, 眞庭 謙昌, 掛地 吉弘

  一般社団法人日本外科学会, 05 Mar. 2014, 日本外科学会雑誌, 115(2) (2), 822 - 822, Japanese


• 肺手術前の高解像度 ３D-CTによる肺血管同定の有用性

  Maniwa Yoshimasa, 田根 慎也, 大野 良治

  (株)オプトロニクス社, 2014, MEDICAL PHOTONICS, (16) (16), 9 - 14, Japanese

  [Refereed]

  Introduction scientific journal


• 肺手術前の高解像度3D-CTによる肺血管同定の有用性

  Maniwa Yoshimasa, Tane Shinya, Ohno Yoshiharu

  (株)オプトロニクス社, Jan. 2014, Medical Photonics, (16号) (16号), 9 - 14, Japanese

  [Refereed]

  Introduction commerce magazine


• 討論 (胸部外科の指針 若年者自然気胸における胸腔鏡下手術法と術後再発)

  眞庭 謙昌, 栁澤 純, 岩﨑 昭憲

  南江堂, Nov. 2013, 胸部外科 = The Japanese journal of thoracic surgery, 66(12) (12), 1038 - 1040, Japanese


• 討論１

  Maniwa Yoshimasa

  Nov. 2013, 胸部外科, 66(12) (12), 1038 - 1039, Japanese

  [Refereed]

  Introduction scientific journal


• 巨大血腫と血胸を来した胸腺腫の1例

  関 紳一郎, 西尾 瑞穂, 神山 久信, 大野 良治, 真庭 謙昌, 西村 善博, 酒井 康裕, 伊藤 智雄, 杉村 和朗

  (公社)日本医学放射線学会, Sep. 2013, 日本医学放射線学会秋季臨床大会抄録集, 49回, S596 - S596, Japanese


• PS-018-5 肺腺癌におけるPSF3発現の臨床的意義の検討(PS ポスターセッション,第113回日本外科学会定期学術集会)

  法華 大助, 真庭 謙昌, 田根 慎也, 田内 俊輔

  一般社団法人日本外科学会, 05 Mar. 2013, 日本外科学会雑誌, 114(2) (2), 543 - 543, Japanese


• PS-023-6 肺腺癌における予後因子としてのnection-3の発現について(PS ポスターセッション,第113回日本外科学会定期学術集会)

  田内 俊輔, 田根 慎也, 法華 大助, 真庭 謙昌

  一般社団法人日本外科学会, 05 Mar. 2013, 日本外科学会雑誌, 114(2) (2), 550 - 550, Japanese


• WS-9-1 肺腺癌浸潤におけるNecl-5の働きについての検討(WS ワークショップ,第113回日本外科学会定期学術集会)

  田根 慎也, 眞庭 謙昌, 法華 大助, 田内 俊輔

  一般社団法人日本外科学会, 05 Mar. 2013, 日本外科学会雑誌, 114(2) (2), 308 - 308, Japanese


• 術待機中に空洞形成を伴った非定型的肺カルチノイドの一例

  山崎 晴菜, 西尾 瑞穂, 関 紳一郎, 神山 久信, 大野 良治, 酒井 康裕, 真庭 謙昌, 西村 善博, 伊藤 智雄, 杉村 和朗

  (公社)日本医学放射線学会, Aug. 2012, 日本医学放射線学会秋季臨床大会抄録集, 48回, S575 - S575, Japanese


• その検査、本当にそこまで必要ですか? 経過観察のストラテジー【第4回】 呼吸器・縦隔 腫瘍性疾患

  Ohno Yoshiharu, Yoshikawa Takeshi, Matsumoto Sumiaki, Nishio Mizuho, Koyama Hisanobu, Sugimura Kazuro, Onishi Yumiko, Maniwa Yoshimasa, Nishimura Yoshihiro

  (株)メジカルビュー社, Aug. 2012, 臨床画像, 28(8) (8), 996 - 1003, Japanese

  [Refereed][Invited]

  Introduction scientific journal


• 【悪性腫瘍-その合理的な画像診断の進め方】 再発チェックを合理的に行うには 肺癌

  Ohno Yoshiharu, Nishio Mizuho, Onishi Yumiko, Koyama Hisanobu, Yoshikawa Takeshi, Matsumoto Sumiaki, Maniwa Yoshimasa, Nishimura Yoshihiro, Sugimura Kazuro

  (株)メジカルビュー社, Jul. 2012, 臨床画像, 28(7) (7), 786 - 794, Japanese

  [Invited]

  Introduction scientific journal


• 非小細胞肺癌リンパ節転移の定量的診断能 3T-MRI STIR vs.1.5T-MRI STIR vs.PET/CT

  竹中 大祐, 神山 久信, 尾西 由美子, 西尾 瑞穂, 松本 純明, 小谷 義一, 真庭 謙昌, 西尾 渉, 大野 良治, 杉村 和朗

  (NPO)日本肺癌学会, Oct. 2011, 肺癌, 51(5) (5), 634 - 634, Japanese


• Evaluation of Pulmonary Nodules: Area-Detector CT versus Other Multi-Detector Row CT Response

  Yoshiharu Ohno, Hisanobu Koyama, Keiko Matsumoto, Yumiko Onishi, Daisuke Takenaka, Yasuko Fujisawa, Takeshi Yoshikawa, Minoru Konishi, Yoshimasa Maniwa, Yoshihiro Nishimura, Tomoo Ito, Kazuro Sugimura

  Oct. 2011, RADIOLOGY, 261(1) (1), 332 - 333, English

  Report scientific journal


• 胸部MRIにおける拡散強調像とSTIR像を用いた肺小細胞癌と肺非小細胞癌の定量的鑑別の検討

  神山 久信, 大野 良治, 西尾 瑞穂, 竹中 大祐, 真庭 謙昌, 西尾 渉, 小谷 義一, 西村 善博, 杉村 和朗

  (NPO)日本肺癌学会, Oct. 2011, 肺癌, 51(5) (5), 633 - 633, Japanese


• 320列面検出器CTによる定量Perfusion CTによる肺結節診断能 Dynamic MRIおよびPET/CTとの直接比較

  大野 良治, 西尾 瑞穂, 尾西 由美子, 神山 久信, 竹中 大祐, 小谷 義一, 真庭 謙昌, 伊藤 智雄, 西尾 渉, 西村 善博, 杉村 和朗

  (NPO)日本肺癌学会, Oct. 2011, 肺癌, 51(5) (5), 448 - 448, Japanese


• 胸部CTにおけるすりガラス状影を伴った病変の自動測定

  西尾 瑞穂, 松本 純明, 神山 久信, 竹中 大祐, 大野 良治, 真庭 謙昌, 西尾 渉, 小谷 義一, 西村 善博, 杉村 和朗

  (NPO)日本肺癌学会, Oct. 2011, 肺癌, 51(5) (5), 634 - 634, Japanese


• SF-061-3 肺腺癌における脱リン酸化酵素Wip1発現の臨床的意義の検討(SF-061 サージカルフォーラム(61)肺:基礎-1,第111回日本外科学会定期学術集会)

  真庭 謙昌, 田根 慎也, 法華 大助, 橋本 章太郎, 西尾 渉, 吉村 雅裕

  一般社団法人日本外科学会, 25 May 2011, 日本外科学会雑誌, 112(1) (1), 411 - 411, Japanese


• Application of hRad9 in lung cancer treatment as a molecular marker and a molecular target

  Yoshimasa Maniwa, Wataru Nishio, Masahiro Yoshimura

  Feb. 2011, THORACIC CANCER, 2(1) (1), 7 - 15, English, International magazine

  [Refereed]


• メタボローム解析を用いた肺癌バイオマーカーの探索

  岡本 朱矢, 小林 和幸, 西海 信, 畠山 由記久, 河 良崇, 永野 達也, 石川 結美子, 中田 恭介, 倉本 衣美, 櫨木 暢子, 山本 正嗣, 坂下 明大, 船田 泰弘, 小谷 義一, 橋本 章太郎, 真庭 謙昌, 西尾 渉, 篠原 正和, 吉田 優, 西村 善博

  (一社)日本呼吸器学会, Mar. 2010, 日本呼吸器学会雑誌, 48(増刊) (増刊), 366 - 366, Japanese


• 320列面検出器CTによるFirst-Pass Perfusion CT vs.FDG-PET/CT 肺結節の良悪性鑑別診断能に関する検討

  大野 良治, 尾西 由美子, 松本 敬子, 神山 久信, 野上 宗伸, 竹中 大祐, 小谷 義一, 真庭 謙昌, 西尾 渉, 西村 善博, 大林 千穂, 杉村 和朗

  (NPO)日本肺癌学会, Oct. 2009, 肺癌, 49(5) (5), 619 - 619, Japanese


• HP-230-4 Damage repair pathwayにおけるNon-synonymous SNPと肺腺癌の発生についての検討(肺(発癌・悪性度・転移),ハイブリッドポスター,第109回日本外科学会定期学術集会)

  田中 雄悟, 真庭 謙昌, 西尾 渉, 吉村 雅裕

  一般社団法人日本外科学会, 25 Feb. 2009, 日本外科学会雑誌, 110(2) (2), 773 - 773, Japanese


• 【肺癌 基礎・臨床研究のアップデート】 疫学・基礎研究 病態 肺癌とアポトーシス

  Maniwa Yoshimasa

  (株)日本臨床社, Aug. 2008, 日本臨床, 66巻, 増刊6 肺癌, pp. 125-134(増刊6 肺癌) (増刊6 肺癌), 113 - 117, Japanese

  Introduction scientific journal


• WS11-6 悪性胸膜中皮腫(MPM)手術例の検討(ワークショップ 悪性中皮腫,第48回日本肺癌学会総会号)

  岩永 幸一郎, 吉村 雅裕, 内野 和哉, 田内 俊輔, 北村 嘉隆, 里内 美弥子, 足立 秀治, 根来 俊一, 高田 佳木, 大林 千穂, 西尾 渉, 真庭 謙昌, 大野 良治, 小谷 義一, 西村 善博

  日本肺癌学会, 10 Oct. 2007, 肺癌, 47(5) (5), 468 - 468, Japanese


• P-94 非小細胞肺癌患者の術後肺機能予測に関する検討 : Dynamic Perfusion MRI,MDCT及び肺血流SPECTの対比(一般演題(ポスター) 縮小手術・その他,第48回日本肺癌学会総会)

  大野 良治, 尾西 由美子, 神山 久信, 野上 宗伸, 竹中 大祐, 松本 純明, 小谷 義一, 真庭 謙昌, 西尾 渉, 西村 善博, 吉村 雅裕, 杉村 和朗

  日本肺癌学会, 10 Oct. 2007, 肺癌, 47(5) (5), 548 - 548, Japanese


• 放射線診断と治療の最前線 肺癌患者におけるM因子診断における全身脂肪抑制併用拡散強調画像の有用性に関する検討

  大野 良治, 尾西 由美子, 神山 久信, 野上 宗伸, 竹中 大祐, 松本 純明, 小谷 義一, 真庭 謙昌, 西尾 渉, 西村 善博, 大林 千穂, 杉村 和朗

  (NPO)日本肺癌学会, Oct. 2007, 肺癌, 47(5) (5), 445 - 445, Japanese


• FDG-PETの意義と応用 非小細胞肺癌術後患者における切除断端部再発 FDG-PET/CTと造影CTの診断能比較

  尾西 由美子, 大野 良治, 神山 久信, 野上 宗伸, 松本 純明, 竹中 大祐, 小谷 義一, 真庭 謙昌, 西尾 渉, 大林 千穂, 西村 善博, 杉村 和朗

  (NPO)日本肺癌学会, Oct. 2007, 肺癌, 47(5) (5), 453 - 453, Japanese


• FDG-PETの意義と応用 PET/CTによる非小細胞肺癌術後患者の再発予測

  竹中 大祐, 大野 良治, 尾西 由美子, 神山 久信, 野上 宗伸, 松本 純明, 小谷 義一, 真庭 謙昌, 西尾 渉, 大林 千穂, 西村 善博, 杉村 和朗

  (NPO)日本肺癌学会, Oct. 2007, 肺癌, 47(5) (5), 454 - 454, Japanese


• 非造影MRIを用いた肺末梢結節スクリーニング能の検討

  神山 久信, 大野 良治, 尾西 由美子, 野上 宗伸, 松本 純明, 竹中 大祐, 小谷 義一, 真庭 謙昌, 西尾 渉, 大林 千穂, 西村 善博, 杉村 和朗

  (NPO)日本肺癌学会, Oct. 2007, 肺癌, 47(5) (5), 506 - 506, Japanese


• Multi-slice CTによる肺癌のT因子診断

  大野 良治, 神山 久信, 野上 宗伸, 松本 純明, 竹中 大祐, 小谷 義一, 真庭 謙昌, 西村 善博, 大林 千穂, 吉村 雅裕, 杉村 和朗

  (NPO)日本肺癌学会, Apr. 2007, 肺癌, 47(2) (2), 161 - 167, Japanese


• bFGF 含浸ゼラチンシートによるラット静脈グラフトの至 適動脈化に関する研究

  原口知則, 岡田健次, 真庭謙昌, 田畑泰彦, 大北裕

  2006, 第9 回日本組織工学会（2006.9.7－8. 京都）, Japanese

  [Refereed]


• New CT and MR imaging of lung cancer

  Yoshiharu Ohno, Munenobu Nogami, Takanori Higashino, Sumiaki Matsumoto, Daisuke Takenaka, Yoshimasa Maniwa, Miyako Satouchi, Chiho Ohbayashi, Yoshihiro Nishimura, Masahiro Yoshimura, Kazuro Sugimura

  Feb. 2005, Japanese Journal of Lung Cancer, 45(1) (1), 63 - 73, Japanese

  Book review


• 肺癌の画像診断の基礎 CT・MRIの最新技術

  OHNO, Yoshiharu, 野上宗伸, 東野貴徳, MATSUMOTO, Sumiaki, TAKENAKA, Daisuke, MANIWA, Yoshimasa, SATOUCHI,Miyako, OHBAYASHI, Chiho, NISHIMURA, Yoshihiro, YOSHIMURA, Masahiro, SUGIMURA, Kazuro

  (NPO)日本肺癌学会, Feb. 2005, 肺癌, 45巻, 1号, pp. 63-73(1) (1), 63 - 73, Japanese

  Introduction scientific journal


• 肺癌検診におけるMRIの有用性に関する検討

  竹中 大祐, 大野 良治, 東野 貴徳, 野上 宗伸, 真庭 謙昌, 吉村 雅裕, 里内 美弥子, 西村 善博, 大林 千穂, 大林 加代子, 杉村 和朗

  (NPO)日本肺癌学会, Oct. 2004, 肺癌, 44(5) (5), 410 - 410, Japanese


• 肺癌の最新MRI診断

  OHNO, Yoshiharu, 野上宗伸, 東野貴徳, 渡辺裕一, TAKENAKA, Daisuke, MANIWA, Yoshimasa, SATOUCHI,Miyako, NISHIMURA, Yoshihiro, OHBAYASHI, Chiho, YOSHIMURA, Masahiro, SUGIMURA, Kazuro

  (NPO)日本肺癌学会, Dec. 2003, 肺癌, 43巻, 7, pp. 818-825(7) (7), 818 - 825, Japanese

  Introduction scientific journal


• 肺癌胸壁浸潤におけるSTIR Turbo Spin-echo(SE)法による定量的診断法の検討

  竹中 大祐, 大野 良治, 東野 貴徳, 渡辺 裕一, 野上 宗伸, 真庭 謙昌, 吉村 雅裕, 里内 美弥子, 西村 善博, 大林 千穂, 大林 加代子, 杉村 和朗

  (NPO)日本肺癌学会, Oct. 2003, 肺癌, 43(5) (5), 524 - 524, Japanese


• 肺癌治療の現状と将来展望 : stagingの問題点と対策

  吉村 雅裕, 坪田 紀明, 中井 玲子, 岩永 幸一郎, 高田 昌彦, 直樹 直樹, 真庭 謙昌, 大北 裕

  一般社団法人日本外科学会, 30 Apr. 2003, 日本外科学会雑誌, 104, 81 - 82, Japanese


• New MR Imaging of Lung Cancer

  Yoshiharu Ohno, Munenobu Nogami, Takanori Higashino, Hirokazu Watanabe, Daisuke Takenaka, Yoshimasa Maniwa, Miyako Satouchi, Yoshihiro Nishimura, Chiho Ohbayashi, Masahiro Yoshimura, Kazuro Sugiyama

  Japan Lung Cancer Society, 2003, Japanese Journal of Lung Cancer, 43(7) (7), 818 - 825, Japanese

  Book review


• 72.同時性3重肺癌の1手術例(第74回日本肺癌学会関西支部会)

  岩永 幸一郎, 吉村 雅裕, 真庭 謙昌, 大北 裕, 西村 善博, 西馬 照明, 船田 泰弘, 小林 和幸, 島田 天美子, 浦田 佳子, 吉村 将, 竹中 大祐, 大野 良治, 渡辺 裕一, 大林 千穂

  日本肺癌学会, 20 Oct. 2001, 肺癌, 41(6) (6), 725 - 725, Japanese


• 42. 気管支形成術を要した末梢小型肺癌の1手術例

  真庭 謙昌, 吉村 雅裕, 大北 裕, 足立 秀治, 竹中 大祐, 渡辺 裕一, 杉村 和朗, 西村 善博, 西馬 照明, 船田 泰弘, 吉村 将, 大林 千穂

  日本肺癌学会, 20 Apr. 2001, 肺癌, 41(2) (2), 176 - 176, Japanese


• CT/HRCTで5年7ヵ月の経過が追跡可能であった早期肺腺癌(野口B型)の1例

  渡辺 裕一, 野上 宗伸, 竹中 大祐, 大野 良治, 足立 秀治, 杉村 和朗, 山本 英博, 真庭 謙昌, 大北 裕, 大林 千穂

  (公社)日本医学放射線学会, Sep. 2000, 日本医学放射線学会雑誌, 60(10) (10), S367 - S367, Japanese

• Clinical significance of the "not otherwise specified" subtype in candidates for resectable non-small cell lung cancer. / Clinical significance of the "not otherwise specified" subtype in candidates for resectable non-small cell lung cancer.

  Tane S, Nishio W, Ogawa H, Hokka D, Tane K, Tanaka Y, Tauchi S, Uchino K, Sakai Y, Ohbayashi C, Yoshimura M, Maniwa Yoshimasa

  Others, Oncol Lett, Sep. 2014, English

  Scholarly book


• Single-incision thoracoscopic surgery using a chest wall pulley for lung excision in patients with primary spontaneous pneumothorax. / Single-incision thoracoscopic surgery using a chest wall pulley for lung excision in patients with primary spontaneous p

  Tsuboshima K, Wakahara T, Matoba Y, Miyauchi H, Hayashi C, Kobayashi I, Oue H, Watanabe Y, Ono T, Maniwa Yoshimasa

  Others, Surg Today, May 2014, English

  Scholarly book


• Diffusion-weighted MR imaging vs. multi-detector row CT: Direct comparison of capability for assessment of management needs for anterior mediastinal solitary tumors. / Diffusion-weighted MR imaging vs. multi-detector row CT: Direct comparison of capabilit

  Seki S, Koyama H, Ohno Y, Nishio M, Takenaka D, Maniwa Yoshimasa, Itoh T, Nishimura Y, Sugimura K

  Others, Eur J Radiol, May 2014, English

  Scholarly book

• 呼吸器悪性４ 縦隔リンパ節郭清２

  MANIWA YOSHIMASA

  第31回日本内視鏡外科学会総会, Dec. 2018, Japanese, 博多, Domestic conference

  [Invited]

  Invited oral presentation


• 肺病変合併肺癌1

  MANIWA YOSHIMASA

  第59回日本肺癌学会学術集会, Nov. 2018, Japanese, 東京, Domestic conference

  Oral presentation


• 切除範囲の決定にAFIが有用であった気管分岐部切除を伴う左肺全摘術の１例

  MANIWA YOSHIMASA

  第39回日本レーザー医学会総会, Nov. 2018, Japanese, 東京, Domestic conference

  Oral presentation


• 気管支断端瘻治療の考え方―安全な外科手術を目指して―

  MANIWA YOSHIMASA

  第80回日本臨床外科学会総会, Nov. 2018, Japanese, 東京, Domestic conference

  Invited oral presentation


• Sleeve pneumonectomyを行った２手術例の検討

  黒田 紗菜恵, TANAKA YUGO, SHIMIZU NAHOKO, HOKKA DAISUKE, MANIWA YOSHIMASA

  第70回日本気管食道科学会総会ならびに学術講演会, Nov. 2018, Japanese, 東京, Domestic conference

  Oral presentation


• JLCS/KASLC Joint Symposium

  Maniwa Yoshimasa

  第59回日本肺癌学会学術集会, Nov. 2018, English, 東京, Domestic conference

  Public discourse


• 肺癌２

  MANIWA YOSHIMASA

  第71回日本胸部外科学会定期学術集会, Oct. 2018, Japanese, 東京, Domestic conference

  [Invited]

  Invited oral presentation


• 縦隔発生の骨外性骨肉腫の一例

  岸田 雄治, OHNO YOSHIHARU, SEKI SHINICHIRO, JIMBO NAOE, ITO TOMOO, TANAKA YUGO, MANIWA YOSHIMASA, MURAKAMI TAKAMICHI

  第54回日本医学放射線学会秋季大会, Oct. 2018, Japanese, 日本医学放射線学会, 福岡, Domestic conference

  Oral presentation


• Safe and less invasive thoracic surgery

  Maniwa Yoshimasa

  50th Annual Autumn Congress of the Korean Society for Thoraic & Cardiovascular Surgery, Oct. 2018, Japanese, Seoul, International conference

  [Invited]

  Invited oral presentation


• 非小細胞肺癌（非扁平上皮癌）完全切除症例に対するCDDP+PEMショートハイドレーション療法による術後補助化学療法の認容性試験

  奥野 恵子, TACHIHARA MOTOKO, 徳永 俊太郎, 堂國 良太, KATSURADA NAOKO, NAKATA KYOSUKE, YAMAMOTO MASATSUGU, KAMIRYO HIROSHI, KOBAYASHI KAZUYUKI, TANAKA YUGO, 船田 泰弘, MANIWA YOSHIMASA, NISHIMURA YOSHIHIRO

  第16回 日本臨床腫瘍学会学術集会, Jul. 2018, Japanese, 神戸, Domestic conference

  Oral presentation


• 肺性肥大性骨関節症を合併したROS1融合遺伝子陽性肺癌の一例

  KATSURADA NAOKO, 小山貴与子, NAKATA KYOSUKE, YAMAMOTO MASATSUGU, TANAKA YUGO, TACHIHARA MOTOKO, KAMIRYO HIROSHI, MANIWA YOSHIMASA, NISHIMURA YOSHIHIRO

  第108回肺癌学会関西支部会, Jun. 2018, Japanese, 大阪, Domestic conference

  Oral presentation


• 胸部発生の肉腫〜外科治療の限界を求めて〜

  MANIWA YOSHIMASA

  第61回関西胸部外科学会学術集会, Jun. 2018, Japanese, 名古屋, Domestic conference

  [Invited]

  Invited oral presentation


• 再発気胸

  MANIWA YOSHIMASA

  第35回日本呼吸器外科学会総会・学術集会, May 2018, Japanese, 幕張, Domestic conference

  [Invited]

  Invited oral presentation


• 肺-集学的治療-2・その他

  MANIWA YOSHIMASA

  第118回日本外科学会定期学術集会, Apr. 2018, Japanese, 東京, Domestic conference

  Poster presentation


• Feasibility study of adjuvant chemotherapy with cisplatin and pemetrexed short hydration regimen for completely resected non-small cell lung cancer

  Ryota Dokuni, Motoko Tachihara, Shuntaro Tokunaga, Keiko Okuno, Masatsugu Yamamoto, Kazuyuki Kobayashi, Yugo Tanaka, Yasuhiro Funada, Yoshimasa Maniwa, Yoshihiro Nishimura

  European Lung Cancer Congress 2018, Apr. 2018, English, Geneva, International conference

  Oral presentation


• 胸腺類基底細胞癌の一例

  松本 学, Ogawa Hiroyuki, 光井 卓, 西岡 祐希, 松本 高典, 金 泰雄, 木村 賢司, Shimizu Nahoko, Hokka Daisuke, Tanaka Yugo, Maniwa Yoshimasa

  第107回日本肺癌学会関西支部学術集会, Feb. 2018, Japanese, 日本肺癌学会関西支部学術集会, 大阪, Domestic conference

  Oral presentation


• 当院における自然気胸に対する単孔式胸腔鏡下手術の検討

  西岡 祐希, Hokka Daisuke, 光井 卓, 松本 学, 松本 高典, 金 泰雄, 木村 賢司, Shimizu Nahoko, Ogawa Hiroyuki, Tanaka Yugo, Maniwa Yoshimasa

  第102回日本呼吸器内視鏡学会近畿支部会, Nov. 2017, Japanese, 日本呼吸器内視鏡学会近畿支部会, 大阪, Domestic conference

  Oral presentation


• 人工肺癌幹細胞を用いた、肺癌組織再構築と新規治療法開発の試み

  Ogawa Hiroyuki, Aoi Michiyo, Aoi Takashi, Maniwa Yoshimasa

  第58回日本肺癌学会学術集会, Oct. 2017, Japanese, 日本肺癌学会, 横浜, Domestic conference

  Oral presentation


• 診断的治療目的に手術した後縦隔神経節細胞腫の3例

  松本 高典, Ogawa Hiroyuki, 酒井 秀都, 金 泰雄, 内田 孝宏, 木村 賢司, Shimizu Nahoko, Tanaka Yugo, Maniwa Yoshimasa

  第58回日本肺癌学会学術集会, Oct. 2017, Japanese, 日本肺癌学会学術集会, 横浜, Domestic conference

  Oral presentation


• 初発から15年の経過で肺転移を生じたgrade l髄膜腫の一例

  金 泰雄, Ogawa Hiroyuki, 酒井 秀都, 松本 高典, 内田 孝宏, 木村 賢司, Shimizu Nahoko, Hokka Daisuke, Tanaka Yugo, Maniwa Yoshimasa

  第58回日本肺癌学会学術集会, Oct. 2017, Japanese, 日本肺癌学会学術集会, 横浜, Domestic conference

  Poster presentation


• 左上区域に限局する転移性肺動脈腫瘍塞栓に対し外科的切除を行った1例

  内田 孝宏, Tanaka Yugo, 松本 高典, 金 泰雄, 木村 賢司, Shimizu Nahoko, Ogawa Hiroyuki, Hokka Daisuke, Maniwa Yoshimasa

  第58回日本肺癌学会学術集会, Oct. 2017, Japanese, 日本肺癌学会学術集会, 横浜, Domestic conference

  Poster presentation


• 胸腺嚢胞に合併した胸腺癌の一切除例

  松本 学, Ogawa Hiroyuki, 松本 高典, 酒井 秀都, 金 泰雄, 内田 孝宏, 木村 賢司, Shimizu Nahoko, Tanaka Yugo, Maniwa Yoshimasa

  第58回日本肺癌学会学術集会, Oct. 2017, Japanese, 日本肺癌学会学術集会, 横浜, Domestic conference

  Poster presentation


• 気管支原生嚢胞からの発生が疑われた平滑筋肉腫の一切除例

  木村 賢司, Ogawa Hiroyuki, 酒井 秀都, 松本 高典, 内田 孝宏, 金 泰雄, Shimizu Nahoko, Hokka Daisuke, Tanaka Yugo, Maniwa Yoshimasa

  第58回日本肺癌学会学術集会, Oct. 2017, Japanese, 日本肺癌学会学術集会, 横浜, Domestic conference

  Poster presentation


• 気管支形成を伴う区域切除術を要した両側同時多発肺癌の手術例

  Shimizu Nahoko, Tanaka Yugo, 酒井 秀都, 松本 高典, 内田 孝宏, 金 泰雄, 木村 賢司, Ogawa Hiroyuki, Hokka Daisuke, Maniwa Yoshimasa

  第58回日本肺癌学会学術集会, Oct. 2017, Japanese, 日本肺癌学会学術集会, 横浜, Domestic conference

  Oral presentation


• 右Ｓ2区域切除術後9年目に完全胸腔鏡下completion lobectomy を行った1例

  Tanaka Yugo, 酒井 秀都, 松本 高典, 内田 孝宏, 金 泰雄, 木村 賢司, Shimizu Nahoko, Ogawa Hiroyuki, Hokka Daisuke, Maniwa Yoshimasa

  第58回日本肺癌学会学術集会, Oct. 2017, Japanese, 日本肺癌学会学術集会, 横浜, Domestic conference

  Oral presentation


• ポスター5 「希少症例1」

  Maniwa Yoshimasa

  第58回日本肺癌学会学術集会, Oct. 2017, Japanese, 日本肺癌学会学術集会, 横浜, Domestic conference

  Others


• ポスター(呼吸器21) 基礎実験1

  Maniwa Yoshimasa

  第70回日本胸部外科学会学術集会, Sep. 2017, Japanese, 日本胸部外科学会学術集会, 札幌, Domestic conference

  Others


• Propensity score matching 法を用いた高悪性度肺神経内分泌癌に対する補助化学療法の検討

  Ogawa Hiroyuki, Tanaka Yugo, 金 泰雄, 木村 賢司, Shimizu Nahoko, Hokka Daisuke, 西尾 渉, 吉村 雅裕, Maniwa Yoshimasa

  第70回日本胸部外科学会学術集会, Sep. 2017, Japanese, 日本胸部外科学会学術集会, 札幌, Domestic conference

  Oral presentation


• 嚢胞内に発生した肺線原発類基低細胞癌の一例

  松本 学, Shimizu Nahoko, 光井 卓, 西岡 祐希, 松本 高典, 金 泰雄, 木村 賢司, Ogawa Hiroyuki, Hokka Daisuke, Tanaka Yugo, Maniwa Yoshimasa

  第106回日本肺癌学会関西支部会, Jun. 2017, Japanese, 日本肺癌学会関西支部会, 大阪, Domestic conference

  Oral presentation


• 人工癌幹細胞と癌オルガノイドを用いた癌幹細胞研究

  Aoi Takashi, 石田 諒, Ogawa Hiroyuki, Aoi Michiyo, Kakeji Yoshihiro, Maniwa Yoshimasa

  第27回日本サイトメトリー学会学術集会, Jun. 2017, Japanese, 日本サイトメトリー学会, 神戸, Domestic conference

  [Invited]

  Nominated symposium


• 検診にて発見された後縦隔神経節細胞腫の1切除例

  松本 高典, Ogawa Hiroyuki, 酒井 秀都, 金 泰雄, 内田 孝宏, 木村 賢司, Shimizu Nahoko, Tanaka Yugo, Maniwa Yoshimasa

  第60回関西胸部外科学会学術集会, Jun. 2017, Japanese, 関西胸部外科学会学術集会, 大阪, Domestic conference

  Oral presentation


• 異なるアプローチにて鎖骨下動脈再建を行った肺尖部胸壁浸潤癌の2例

  Tanaka Yugo, 酒井 秀都, 松本 高典, 内田 孝宏, 金 泰雄, 木村 賢司, Shimizu Nahoko, Ogawa Hiroyuki, Hokka Daisuke, Maniwa Yoshimasa

  第60回関西胸部外科学会学術集会, Jun. 2017, Japanese, 関西胸部外科学会学術集会, 大阪, Domestic conference

  Oral presentation


• 安全な胸腔鏡下肺葉切除術・縦隔リンパ節郭清のために

  Maniwa Yoshimasa

  第106回日本肺癌学会関西支部会, Jun. 2017, Japanese, 日本肺癌学会関西支部会, 大阪, Domestic conference

  Others


• Case Presentation Award 16 呼吸器5

  Maniwa Yoshimasa

  第60回関西胸部外科学会学術集会, Jun. 2017, Japanese, 関西胸部外科学会学術集会, 大阪, Domestic conference

  Others


• 要望演題14 呼吸器外科手術に おける教育、 トレーニング

  Maniwa Yoshimasa

  第34回日本呼吸器外科学会総会, May 2017, Japanese, 日本呼吸器外科学会総会, 福岡, Domestic conference

  Others


• 続発性気胸に対する手術症例の検討

  Hokka Daisuke, 松本 高典, 酒井 秀都, 内田 孝宏, 金 泰雄, 木村 賢司, Shimizu Nahoko, Ogawa Hiroyuki, Tanaka Yugo, Maniwa Yoshimasa

  第34回日本呼吸器外科学会総会, May 2017, Japanese, 日本呼吸器外科学会総会, 福岡, Domestic conference

  Oral presentation


• 人工肺癌幹細胞による、肺癌組織再構築の試み

  Ogawa Hiroyuki, Shimizu Nahoko, Hokka Daisuke, Tanaka Yugo, Aoi Michiyo, Aoi Takashi, Maniwa Yoshimasa

  第34回日本呼吸器外科学会総会, May 2017, Japanese, 日本呼吸器外科学会, 福岡, Domestic conference

  Oral presentation


• 術後横隔神経麻痺に対する横隔膜縫縮術の検討

  内田 孝宏, Tanaka Yugo, 酒井 秀都, 松本 高典, 金 泰雄, 木村 賢司, Shimizu Nahoko, Ogawa Hiroyuki, Hokka Daisuke, Maniwa Yoshimasa

  第34回日本呼吸器外科学会総会, May 2017, Japanese, 日本呼吸器外科学会総会, 福岡, Domestic conference

  Poster presentation


• 骨軟部悪性腫瘍における肺転移切除例の治療成績

  Kawamoto Teruya, Hara Hitomi, 深瀬 直政, 森下 雅之, 片山 悦子, 竹森 俊幸, Tanaka Yugo, Maniwa Yoshimasa, Kuroda Ryosuke, Akisue Toshihiro

  The 90th Annual Meetin of the Japanese Orthopaedic Association, May 2017, Japanese, The Japanese Orthopaedic Association, 仙台, Domestic conference

  Poster presentation


• 血液透析患者に対する原発性肺癌手術症例の検討

  木村 賢司, Ogawa Hiroyuki, Tanaka Yugo, 酒井 秀都, 松本 高典, 内田 孝宏, 金 泰雄, Shimizu Nahoko, Hokka Daisuke, Maniwa Yoshimasa

  第34回日本呼吸器外科学会総会, May 2017, Japanese, 日本呼吸器外科学会総会, 福岡, Domestic conference

  Poster presentation


• 胸腺腫に関連した新規疾患概念、抗PIT-1 抗体症候群

  松本 高典, Ogawa Hiroyuki, 酒井 秀都, 金 泰雄, 内田 孝宏, 木村 賢司, Shimizu Nahoko, Tanaka Yugo, 板東 弘教, Iguchi Genzo, Takahashi Yutaka, Maniwa Yoshimasa

  第34回日本呼吸器外科学会総会, May 2017, Japanese, 日本呼吸器外科学会総会, 福岡, Domestic conference

  Oral presentation


• 完全鏡視下手術手技を用いた拡大手術についての検討

  Tanaka Yugo, 酒井 秀都, 松本 髙典, 内田 孝宏, 金 泰雄, 木村 賢司, Shimizu Nahoko, Ogawa Hiroyuki, Hokka Daisuke, Maniwa Yoshimasa

  第34回日本呼吸器外科学会総会, May 2017, Japanese, 日本呼吸器外科学会総会, 福岡, Domestic conference

  Oral presentation


• 外科的切除によって著名な改善を認めた胸壁発生の腫瘍性低リン血症性軟骨化症の一例

  金 泰雄, Ogawa Hiroyuki, 酒井 秀都, 松本 高典, 内田 孝宏, 木村 賢司, Shimizu Nahoko, Hokka Daisuke, Tanaka Yugo, Maniwa Yoshimasa

  第34回日本呼吸器外科学会総会, May 2017, Japanese, 日本呼吸器外科学会総会, 福岡, Domestic conference

  Poster presentation


• 外科医に必要な肺生理学の基礎知識

  Maniwa Yoshimasa

  第23回 呼吸器外科セミナー, May 2017, Japanese, 呼吸器外科セミナー, 福岡, Domestic conference

  Others


• Volume reductionにて症状が改善した縦隔原発骨外性骨肉腫の1例

  Shimizu Nahoko, Tanaka Yugo, 酒井 秀都, 松本 高典, 内田 孝宏, 金 泰雄, 木村 賢司, Ogawa Hiroyuki, Hokka Daisuke, Maniwa Yoshimasa

  第34回日本呼吸器外科学会総会, May 2017, Japanese, 日本呼吸器外科学会総会, 福岡, Domestic conference

  Poster presentation


• ポスターセッション（146）「肺-診断」

  Maniwa Yoshimasa

  第117回 日本外科学会定期学術集会, Apr. 2017, Japanese, 日本外科学会定期学術集会, 横浜, Domestic conference

  Others


• Interleukin-6 blockade, a novel cancer stem cell targeted therapy, attenuates lung cancer tissue construction.

  Ogawa Hiroyuki, Aoi Michiyo, Aoi Takashi, Maniwa Yoshimasa

  American Association for Cancer Research annual meeting 2017, Apr. 2017, English, American Association for Cancer Research, Washington D.C., USA, International conference

  Poster presentation


• Role of Ror2 tyrosine kinase in ivasiveness of malignant pleural mesothelioma cells.

  Takeshi Saji, Nishita Michiru, Takefumi Doi, Maniwa Yoshimasa, Minami Yasuhiro

  International Joint Symposium in Kobe 2017 University of Washington University of Oslo and Kobe University, Mar. 2017, English, Kobe University, University of Washington, University of Oslo, 神戸, Malignant mesothelioma is a highly aggressive tumour originated from mesothelial cells of the pleura, pericardium or peritoneum. Among them, malignant pleural mesothelioma (MPM) is most common with increasing frequency throughout the world and closely related to exposure to asbestos. It can be classified histologically into epithelioid, sarcomatoid and biphasic types, among wh, International conference

  Poster presentation


• Psf3 is a prognostic biomarker in lung adenocarcinoma:a larger trial using tissue microarrays of 864 consecutive resections

  Maniwa Yoshimasa

  134. Kongresses der Deutschen Gesellschaft für Chirurgie, Mar. 2017, Japanese, Kongresses der Deutschen Gesellschaft für Chirurgie, ミュンヘン, ドイツ, International conference

  Oral presentation


• 縦隔原発骨外性骨肉腫の1例

  内田 孝宏, Tanaka Yugo, Shimizu Nahoko, 酒井 秀都, 松本 高典, 金 泰雄, 木村 賢司, Ogawa Hiroyuki, Hokka Daisuke, Maniwa Yoshimasa

  第105回日本肺癌学会関西支部会, Feb. 2017, Japanese, 日本肺癌学会関西支部会, 大阪, Domestic conference

  Oral presentation


• 病理組織診断で大細胞神経内分泌癌の中咽頭転移が判明した1例

  大隈 宏通, 奥田 祐亮, 内田 孝宏, Shimizu Nahoko, Ogawa Hiroyuki, Hokka Daisuke, Tanaka Yugo, Maniwa Yoshimasa

  第57回日本肺癌学会学術集会, Dec. 2016, Japanese, 日本肺癌学会, 福岡, Domestic conference

  Oral presentation


• 肺結節切除標本内にびまん性特発性神経内分泌細胞過形成と多発tumorletを認めた1例

  酒井 秀都, Tanaka Yugo, 松本 高典, 内田 孝宏, 金 泰雄, 木村 賢司, Shimizu Nahoko, Ogawa Hiroyuki, Hokka Daisuke, Maniwa Yoshimasa

  第57回日本肺癌学会学術集会, Dec. 2016, Japanese, 日本肺癌学会, 福岡, Domestic conference

  Oral presentation


• 転移性脳腫瘍の発見から1年後に診断・手術に至ったpT1aN0M1bの原発性肺腺癌の1例

  金 泰雄, Tanaka Yugo, 酒井 秀都, 松本 高典, 内田 孝宏, 木村 賢司, Shimizu Nahoko, Ogawa Hiroyuki, Hokka Daisuke, Maniwa Yoshimasa

  第57回日本肺癌学会学術集会, Dec. 2016, Japanese, 日本肺癌学会, 福岡, Domestic conference

  Oral presentation


• 全身PET/MRI、MRI、PET/CT及び通常画像検査における胸腺上皮性腫瘍の病期診断能の比較

  Ohno Yoshiharu, 岸田 雄二, Seki Shinichiro, Yoshikawa Takeshi, 田村 大介, Tanaka Yugo, Tachihara Motoko, Kobayashi Kazuyuki, Sakai Yasuhiro, Maniwa Yoshimasa, Nishimura Yoshihiro

  第57回日本肺癌学会学術集会, Dec. 2016, Japanese, 日本肺癌学会, 福岡, Domestic conference

  Oral presentation


• 小細胞癌に対する外科的治療効果についての検討

  Tanaka Yugo, 酒井 秀都, 松本 高典, 内田 孝宏, 金 泰雄, 木村 賢司, Shimizu Nahoko, Ogawa Hiroyuki, Hokka Daisuke, 多根 健太, 西尾 渉, 吉村 雅裕, Maniwa Yoshimasa

  第57回日本肺癌学会学術集会, Dec. 2016, Japanese, 日本肺癌学会, 福岡, Domestic conference

  Oral presentation


• 次元CTコンピューター体積測定システムの臨床応用 経過観察CTによる良・悪性結節鑑別能評価

  Ohno Yoshiharu, 岸田 雄二, Seki Shinichiro, Yoshikawa Takeshi, 田村 大介, Tanaka Yugo, Tachihara Motoko, Kobayashi Kazuyuki, Sakai Yasuhiro, Maniwa Yoshimasa, Nishimura Yoshihiro

  第57回日本肺癌学会学術集会, Dec. 2016, Japanese, 日本肺癌学会, 福岡, Domestic conference

  Oral presentation


• 左上区域支入口部腫瘍に対して完全鏡視下左上区域切除術を行った1例

  内田 孝宏, Tanaka Yugo, 酒井 秀都, 松本 高典, 金 泰雄, 木村 賢司, Shimizu Nahoko, Ogawa Hiroyuki, Hokka Daisuke, Maniwa Yoshimasa

  第57回日本肺癌学会学術集会, Dec. 2016, Japanese, 日本肺癌学会, 福岡, Domestic conference

  Oral presentation


• 胸壁浸潤肺癌手術に対する低侵襲化への工夫

  Hokka Daisuke, 酒井 秀都, 金 泰雄, 内田 孝宏, 木村 賢司, Shimizu Nahoko, Tanaka Yugo, Maniwa Yoshimasa

  第57回日本肺癌学会学術集会, Dec. 2016, Japanese, 日本肺癌学会, 福岡, Domestic conference

  Oral presentation


• 急速に増大し縦隔偏位をきたした肺癌合併巨大肺嚢胞の一例

  木村 賢司, Tanaka Yugo, 酒井 秀都, 松本 高典, 内田 孝宏, 金 泰雄, Shimizu Nahoko, Ogawa Hiroyuki, Hokka Daisuke, Maniwa Yoshimasa

  第57回日本肺癌学会学術集会, Dec. 2016, Japanese, 日本肺癌学会, 福岡, Domestic conference

  Oral presentation


• 完全胸腔鏡下における予防的気管支断端被覆症例の検討

  Shimizu Nahoko, Tanaka Yugo, 酒井 秀都, 松本 高典, 内田 孝宏, 金 泰雄, 木村 賢司, Ogawa Hiroyuki, Hokka Daisuke, Maniwa Yoshimasa

  第57回日本肺癌学会学術集会, Dec. 2016, Japanese, 日本肺癌学会, 福岡, Domestic conference

  Oral presentation


• 右房内に進展した巨大浸潤性胸腺腫に対し人工心肺を用い完全切除可能であった1例

  Tanaka Yugo, 酒井 秀都, 松本 高典, 内田 孝宏, 金 泰雄, 木村 賢司, Shimizu Nahoko, Ogawa Hiroyuki, Hokka Daisuke, Maniwa Yoshimasa

  第57回日本肺癌学会学術集会, Dec. 2016, Japanese, 日本肺癌学会, 福岡, Domestic conference

  Oral presentation


• 咽頭転移を生じた大細胞神経内分泌癌の1例

  松本 学, Ogawa Hiroyuki, 松本 高典, 酒井 秀都, 金 泰雄, 内田 孝宏, 木村 賢司, Shimizu Nahoko, Hokka Daisuke, Tanaka Yugo, Maniwa Yoshimasa

  第57回日本肺癌学会学術集会, Dec. 2016, Japanese, 日本肺癌学会, 福岡, Domestic conference

  Oral presentation


• 3次元肺癌CT検診用コンピューター支援診断システムの低線量化における再構成の影響に関する比較検討

  Ohno Yoshiharu, 岸田 雄二, Seki Shinichiro, Yoshikawa Takeshi, 田村 大介, Tanaka Yugo, Tachihara Motoko, Kobayashi Kazuyuki, Sakai Yasuhiro, Maniwa Yoshimasa, Nishimura Yoshihiro

  第57回日本肺癌学会学術集会, Dec. 2016, Japanese, 日本肺癌学会, 福岡, Domestic conference

  Oral presentation


• 3次元 CTコンピューター体積測定システムの臨床応用：経過観察CTによる良・悪性結節鑑別能評価

  Ohno Yoshiharu, 岸田 雄二, Seki Shinichiro, Yoshikawa Takeshi, 田村 大介, 田中 雄吾, Tachihara Motoko, Kobayashi Kazuyuki, Sakai Yasuhiro, Maniwa Yoshimasa, Nishimura Yoshihiro

  第57回日本肺癌学会学術集会, Dec. 2016, Japanese, 日本肺癌学会, 福岡, Domestic conference

  Poster presentation


• x Gateを用いた単孔式自然気胸手術の有用性の検討

  Hokka Daisuke, 酒井 秀都, 金 秦雄, 内田 孝宏, 木村 賢司, Shimizu Nahoko, Tanaka Yugo, Maniwa Yoshimasa

  第20回日本気胸・嚢胞性肺疾患学会, Sep. 2016, Japanese, 日本気胸・嚢胞性肺疾患学会, 東京, Domestic conference

  Oral presentation


• 悪性黒色腫の肺転移と思われた1例

  Jimbo Naoe, 大谷 恭子, Sakai Yasuhiro, 川本 めぐみ, 羽間 大祐, 堂國 良太, 吉崎 飛鳥, 桐生 辰徳, 関谷 怜奈, 寺下 智美, 梅澤 佳乃子, 尾野 慶彦, 三輪 菜々子, 桂田 雅大, 徳永 俊太郎, 桂田 直子, 田村 大介, Nagano Tatsuya, Nakata Kyosuke, Yamamoto Masatsugu, Tachihara Motoko, Kobayashi Kazuyuki, Nishimura Yoshihiro, 酒井 秀都, 内田 孝宏, 金 泰雄, 木村 賢司, Shimizu Nahoko, Ogawa Hiroyuki, 法華 大介, Tanaka Yugo, Maniwa Yoshimasa, Ohno Yoshiharu

  第104回日本肺癌学会関西支部会, Jul. 2016, Japanese, 日本肺癌学会, 大阪, Domestic conference

  Poster presentation


• 体細胞初期化因子導入による肺癌幹細胞誘導

  Ogawa Hiroyuki, Hokka Daisuke, Tanaka Yugo, Aoi Takashi, Maniwa Yoshimasa

  第33回日本呼吸器外科学会, May 2016, Japanese, 日本呼吸器外科学会, 京都, Domestic conference

  Oral presentation


• 周術期に感染性大動脈瘤を合併した降下性壊死性縦隔炎の1手術例

  内田 孝宏, 大隈 宏通, 奥田 祐亮, Shimizu Nahoko, Ogawa Hiroyuki, Hokka Daisuke, Tanaka Yugo, Maniwa Yoshimasa

  第33回日本呼吸器外科学会, May 2016, Japanese, 日本呼吸器外科学会, 京都, Domestic conference

  Oral presentation


• 外傷性肺嚢胞に対して緊急手術を要した1例

  大隈 宏通, 内田 孝宏, 奥田 祐亮, Shimizu Nahoko, Ogawa Hiroyuki, 田根 慎也, Hokka Daisuke, Tanaka Yugo, Maniwa Yoshimasa

  第33回日本呼吸器外科学会, May 2016, Japanese, 日本呼吸器外科学会, 京都, Domestic conference

  Oral presentation


• 右鎖骨下動脈再建を要した肺尖部胸壁浸潤癌の1切除例

  Tanaka Yugo, 内田 孝宏, 大隈 宏通, 奥田 祐亮, Shimizu Nahoko, Ogawa Hiroyuki, Hokka Daisuke, Maniwa Yoshimasa

  第33回日本呼吸器外科学会, May 2016, Japanese, 日本呼吸器外科学会, 京都, Domestic conference

  Oral presentation


• pT1N1非小細胞癌切除例におけるリンパ節病変の進展と予後に関する検討.

  Tanaka Yugo, 奥田 祐亮, 内田 孝宏, 大隈 宏通, Shimizu Nahoko, Ogawa Hiroyuki, Hokka Daisuke, Maniwa Yoshimasa, 西尾 渉, 吉村 雅裕

  第33回日本呼吸器外科学会, May 2016, Japanese, 日本呼吸器外科学会, 京都, Domestic conference

  Oral presentation


• 1cm以下微小肺癌切除例の検討

  奥田 祐亮, 内田 孝宏, 大隈 宏通, Shimizu Nahoko, Ogawa Hiroyuki, Hokka Daisuke, Tanaka Yugo, Maniwa Yoshimasa, 西尾 渉, 吉村 雅裕

  第33回日本呼吸器外科学会, May 2016, Japanese, 日本呼吸器外科学会, 京都, Domestic conference

  Oral presentation


• 縦隔偏移をきたした巨大肺嚢胞の1切除例

  内田 孝宏, 大隈 宏通, 清水 奈保子, 奥田 祐亮, 小川 裕行, Tane Shinya, Hokka Daisuke, Tanaka Yugo, Maniwa Yoshimasa

  第198回近畿外科学会, Dec. 2015, Japanese, 近畿外科学会, 大阪, Domestic conference

  Oral presentation


• 呼吸器 悪性I

  Maniwa Yoshimasa

  第28回日本内視鏡外科学会総会, Dec. 2015, Japanese, 日本内視鏡外科学会総会, 大阪, Domestic conference

  Others


• 胸腺腫瘍4

  Maniwa Yoshimasa

  第56回日本肺癌学会学術集会, Nov. 2015, Japanese, 日本肺癌学会学術集会, 横浜, Domestic conference

  Others


• Oncogenic Function of Psf3 in Non-Small Cell Lung Cancer

  Maniwa Yoshimasa

  CHST Annual Meeting2015, Oct. 2015, English, CHST, モントリオール, カナダ, International conference

  Oral presentation


• YIA(2)：呼吸器

  Maniwa Yoshimasa

  第58回関西胸部外科学会学術集会, Jun. 2015, Japanese, 関西胸部外科学会, 岡山, Domestic conference

  Others


• Validity of thoracoscopic surgery for the resection of pulmonary metastases

  Hokka Daisuke, 内田 孝宏, 大隈 宏通, 小川 裕行, Tane Shinya, Tanaka Yugo, Maniwa Yoshimasa

  EAES 2015(23rd Congress of the European of Endoscopic Surgery), Jun. 2015, English, 欧州内視鏡外科学会議, ブカレスト, ルーマニア, International conference

  Poster presentation


• 肺腺癌におけるCHFR(Checkpoint protein with forkhead and ring finger domain) 発現の意義

  Tane Shinya, 奥田 祐亮, 大隈 宏通, 小川 裕行, Hokka Daisuke, Tanaka Yugo, Maniwa Yoshimasa

  第32回日本呼吸器外科学会総会, May 2015, Japanese, 日本呼吸器外科学会, 高松, Domestic conference

  Oral presentation


• 肺・転移・再発

  Maniwa Yoshimasa

  第115回日本外科学会定期学術集会, Apr. 2015, Japanese, 日本外科学会, 名古屋, Domestic conference

  Others


• 気道狭窄をきたした食道神経鞘腫の1例

  Tane Shinya, 大隈 宏通, 小川 裕行, Hokka Daisuke, Tanaka Yugo, 友野 絢子, Kanaji Shingo, Nakamura Tetsu, Kakeji Yoshihiro, Maniwa Yoshimasa

  第66回日本気管食道科学会, Nov. 2014, Japanese, 日本気管食道科学会, 高知, Domestic conference

  Oral presentation


• 非小細胞肺癌におけるPｓｆ3の役割について

  Tane Shinya, 大隈 宏通, 小川 裕行, Hokka Daisuke, Tanaka Yugo, Maniwa Yoshimasa

  第73回日本癌学会学術集会, Sep. 2014, Japanese, 日本癌学会, 横浜, Domestic conference

  Oral presentation


• 胸腔鏡下自然気胸手術をより確実なものにするためのダブルレイヤー法の検討

  Hokka Daisuke, 大隈 宏通, 小川 裕行, Tane Shinya, Tanaka Yugo, Maniwa Yoshimasa

  第18回日本気胸・嚢胞性肺疾患学会総会, Sep. 2014, Japanese, 日本気胸・嚢胞性肺疾患学会, 福岡, Domestic conference

  Oral presentation


• von Willebrand’s diseaseを基礎疾患にもつ血気胸の1例

  大隈 宏通, Tane Shinya, 小川 裕行, Hokka Daisuke, Tanaka Yugo, Maniwa Yoshimasa

  第18回日本気胸・嚢胞性肺疾患学会総会, Sep. 2014, Japanese, 日本気胸・嚢胞性肺疾患学会, 福岡, Domestic conference

  Oral presentation


• 神経線維腫症II型に伴った腫瘍破裂の1例

  大隈 宏通, Tane Shinya, Hokka Daisuke, Tanaka Yugo, Maniwa Yoshimasa

  第100回日本肺癌学会関西支部会, Jun. 2014, Japanese, 日本肺癌学会関西支部, 大阪, Domestic conference

  Oral presentation


• The significant role of Necl-5 among patients with lung adenocarcinoma

  Tane Shinya, 大隈 宏通, 小川 裕行, Hokka Daisuke, Tanaka Yugo, Maniwa Yoshimasa

  ESTS, Jun. 2014, English, ヨーロッパ胸部外科学会, フランクフルト, ドイツ, International conference

  Oral presentation


• 肺癌術後乾性嗽に対するトシル酸スプラタストの有用性の検討

  Hokka Daisuke, 小川 裕行, Tane Shinya, Hokka Daisuke, 田内 俊輔, Maniwa Yoshimasa

  第31回日本呼吸器外科学会総会, May 2014, Japanese, 日本呼吸器外科学会, 東京, Domestic conference

  Oral presentation


• 高齢者肺葉切除症例early outcomeについて

  Tane Shinya, 大隈 宏通, 小川 裕行, Hokka Daisuke, Tanaka Yugo, Maniwa Yoshimasa

  第31回日本呼吸器外科学会総会, May 2014, Japanese, 日本呼吸器外科学会, 東京, Domestic conference

  Oral presentation


• 完全鏡視下で肺葉切除後の気管支断端被覆術の工夫

  Tanaka Yugo, 小川 裕行, Tane Shinya, Hokka Daisuke, 田内 俊輔, Maniwa Yoshimasa

  第31回日本呼吸器外科学会総会, May 2014, Japanese, 日本呼吸器外科学会, 東京, Domestic conference

  Oral presentation


• Ruptured Thymoma With Homothorax:A Case Report

  Hokka Daisuke, 小川 裕行, Tane Shinya, Tanaka Yugo, 田内 俊輔, Maniwa Yoshimasa

  ATS, May 2014, English, 米国胸部学会, サンフランシスコ, アメリカ, International conference

  Poster presentation


• 当院における大腸癌肺転移切除症例の検討

  Tanaka Kenichi, Kim Kiyonori, Yamashita Kimihiro, Sumi Yasuo, 向山 順子, 西 将康, 石田 諒, 秋山 真吾, 瀧口 豪介, 音羽 泰則, 裏川 直樹, 友野 絢子, 高瀬 信尚, Yamamoto Masashi, Kanaji Shingo, 森川 剛志, Imanishi Tatsuya, Nakamura Tetsu, Suzuki Satoshi, Maniwa Yoshimasa, Kakeji Yoshihiro

  第114回日本外科学会定期学術集会, Apr. 2014, Japanese, 一般社団法人日本外科学会, 京都, Domestic conference

  Poster presentation


• 神経内分泌がんに対する補助化学療法に関する報告

  小川裕行, Tanaka Yugo, Tane Shinya, Hokka Daisuke, 田内 俊輔, 奥田 祐亮, 清水 奈保子, 多根 健太, 内野 和哉, 西尾 渉, 吉村 雅裕, Maniwa Yoshimasa

  第114回日本外科学会総会, Apr. 2014, Japanese, 日本外科学会, 京都, Domestic conference

  Oral presentation


• 高齢者非小細胞肺癌に対する外科治療成績

  田内 俊輔, 小川 裕行, Tane Shinya, Hokka Daisuke, Tanaka Yugo, Maniwa Yoshimasa

  第114回日本外科学会総会, Apr. 2014, Japanese, 日本外科学会, 京都, Domestic conference

  Oral presentation


• NOS(not otherwise specified)の臨床的意義

  Tane Shinya, 小川 裕行, Hokka Daisuke, Tanaka Yugo, 田内 俊輔, Maniwa Yoshimasa

  第114回日本外科学会総会, Apr. 2014, Japanese, 日本外科学会, 京都, Domestic conference

  Oral presentation


• Dual Ex Vivo Lung Perfusion Techniques Ameliorate Airway Hypoxia in Lung Grafts in Rats

  Tanaka Yugo, Shigemura N, Noda K, Saito Yasuyuki, Maniwa Yoshimasa, Bhama JK, D’Cunha J, Pilewski JM, Luketich JD, Bermudez CA

  ISHLC, Apr. 2014, English, 心肺移植学会, サンフランシスコ, アメリカ, International conference

  Oral presentation


• Availability of standardized thoracoscopic lobectomy for lung cancer

  Maniwa Yoshimasa

  GDCH, Mar. 2014, English, ドイツ外科学会, ベルリン, ドイツ, International conference

  Oral presentation


• 臍帯血移植前の消失しない肺浸潤影に対して胸腔鏡下肺葉切除を施行した一例

  盛 崇太郎, 田内 俊輔, 小川 裕行, Tane Shinya, Hokka Daisuke, Tanaka Yugo, Maniwa Yoshimasa

  第99回日本肺癌学会関西支部会, Feb. 2014, Japanese, 日本肺癌学会関西支部, 姫路, Domestic conference

  Oral presentation


• 高齢者非小細胞肺癌に対する外科治療成績

  Tauchi Shunsuke, 小川 裕行, Tane Shinya, Hokka Daisuke, Maniwa Yoshimasa

  第54回日本肺癌学会総会, Nov. 2013, Japanese, 日本肺癌学会, 東京, Domestic conference

  Oral presentation


• 高悪性度神経内分泌癌に対する手術症例の臨床的検討

  小川 裕行, Tanaka Yugo, Tane Shinya, Hokka Daisuke, Tauchi Shunsuke, 奥田 祐亮, 清水 奈保子, 多根 健太, 内野 和哉, 西尾 渉, 吉村 雅裕, Maniwa Yoshimasa

  第54回日本肺癌学会総会, Nov. 2013, Japanese, 日本肺癌学会, 東京, Domestic conference

  Oral presentation


• 胸腔鏡下肺部分切除術のこだわりと工夫-Endo GIA Radial Reload

  Hokka Daisuke, 小川 裕行, Tane Shinya, Tanaka Yugo, Tauchi Shunsuke, Maniwa Yoshimasa

  第26回日本内視鏡学会, Nov. 2013, Japanese, 日本内視鏡学会, 福岡, Domestic conference

  Oral presentation


• 完全鏡視下肺葉切除術における術後合併症、術後補助化学療法の忍容性について-開胸手術との比較

  Tane Shinya, Maniwa Yoshimasa, Hokka Daisuke, Tauchi Shunsuke, 西尾 渉, Okita Yutaka, 吉村 雅裕

  第26回日本内視鏡学会, Nov. 2013, Japanese, 日本内視鏡学会, 福岡, Domestic conference

  Oral presentation


• 非小細胞肺癌切除例におけるNOS(not specific otherwise)の臨床的意義について

  Tane Shinya, 西尾 渉, 小川 裕行, Hokka Daisuke, 多根 健太, Tanaka Yugo, Tauchi Shunsuke, 内野 和哉, 吉村 雅裕, Maniwa Yoshimasa

  第66回日本胸部外科定期学術集会, Oct. 2013, Japanese, 日本胸部外科学会, 仙台, Domestic conference

  Oral presentation


• 転移性肺腫瘍に対する胸腔鏡手術の有用性の検討

  Hokka Daisuke, 小川 裕行, Tane Shinya, Tauchi Shunsuke, Maniwa Yoshimasa

  第66回日本胸部外科定期学術集会, Oct. 2013, Japanese, 日本胸部外科学会, 仙台, Domestic conference

  Oral presentation


• 巨大血腫と血胸を来した胸腺腫の1例

  関 紳一郎, Nishio Mizuho, Koyama Hisanobu, Ohno Yoshiharu, Maniwa Yoshimasa, Nishimura Yoshihiro, Sakai Yasuhiro, Itoh Tomoo, Sugimura Kazuro

  The 49th Autumn Assembly of the Japan Radiological Society, Oct. 2013, Japanese, The Japan Radiological Society, 名古屋, Domestic conference

  Oral presentation


• 環境からのがんとその対応 アスベストと呼吸器癌 アスベスト関連肺癌に関して

  Maniwa Yoshimasa, Sakai Yasuhiro, 内野和哉, 吉村雅裕

  The 51st Annual Meeting of Japan Society of Clinical Oncology, Oct. 2013, Japanese, Japan Society of Clinical Oncology, 京都, Domestic conference

  Oral presentation


• Pleural lavage cytology is a significant prognostic factor for stage I lung adenocarcinoma patients

  Hokka Daisuke, Maniwa Yoshimasa, Tauchi Shunsuke, Tane Shinya, 内野 和哉, 多根 健太, 西尾 渉, 吉村 雅裕

  ECCO＿ESMO＿ESTRO2013, Sep. 2013, English, ESMO, ブリュッセル, オランダ, International conference

  Poster presentation


• The efficacy of 320-detector row computed tomography for the assessment of preoperative pulmonary vasculature of candidates for pulmonary segmentectomy

  Tane Shinya, Hokka Daisuke, Tauchi Shunsuke, Maniwa Yoshimasa

  ESTS 2013, Jun. 2013, English, ESTS, バーミンガム, イギリス, International conference

  Oral presentation


• 肺腺癌浸潤におけるNecl-5発現の意義に関する臨床および実験的検討

  Tane Shinya, Maniwa Yoshimasa, Hokka Daisuke, Tauchi Shunsuke

  第30回日本呼吸器外科学会総会, May 2013, Japanese, 日本呼吸器外科学会, 名古屋, Domestic conference

  Oral presentation


• 厳選ビデオ 胸腔鏡手術における不測の出血時の対応

  Tane Shinya, 小川 裕行, Hokka Daisuke, Tauchi Shunsuke, Maniwa Yoshimasa

  第30回日本呼吸器外科学会総会, May 2013, Japanese, 日本呼吸器外科学会, 名古屋, Domestic conference

  Oral presentation


• Successful prolonged ex vivo lung perfusion for graft preservation in rats

  Tane Shinya, 西尾 渉, Hokka Daisuke, Tauchi Shunsuke, Maniwa Yoshimasa

  第30回日本呼吸器外科学会総会, May 2013, Japanese, 日本呼吸器外科学会, 名古屋, Domestic conference

  Oral presentation


• VATS自然気胸手術をより確実なものにするための当科での工夫

  Hokka Daisuke, Tane Shinya, Tauchi Shunsuke, Maniwa Yoshimasa

  第30回日本呼吸器外科学会総会, May 2013, Japanese, 日本呼吸器外科学会, 名古屋, Domestic conference

  Oral presentation


• The role of Necl-5 in the invasive activity of lung adenocarcinoma

  Tane Shinya, Maniwa Yoshimasa, Hokka Daisuke, Tauchi Shunsuke, 西尾 渉, Okita Yutaka, 吉村 雅裕

  第30回日本呼吸器外科学会総会, May 2013, Japanese, 日本呼吸器外科学会, 名古屋, Domestic conference

  Oral presentation


• Psf3は肺腺癌における予後を判定する新しいバイオマーカーである

  Hokka Daisuke, Tane Shinya, Tauchi Shunsuke, Maniwa Yoshimasa

  第30回日本呼吸器外科学会総会, May 2013, Japanese, 日本呼吸器外科学会, 名古屋, Domestic conference

  Oral presentation


• 肺腺癌浸潤におけるNecl-5の働きについての検討

  Tane Shinya, 小川 裕行, Hokka Daisuke, Tauchi Shunsuke, Maniwa Yoshimasa

  第113回日本外科学会, Apr. 2013, Japanese, 日本外科学会, 福岡, Domestic conference

  Oral presentation


• 肺腺癌における予後因子としてのNectin-3の発現について

  Tauchi Shunsuke, Tane Shinya, Hokka Daisuke, Maniwa Yoshimasa

  第113回日本外科学会, Apr. 2013, Japanese, 日本外科学会, 福岡, Domestic conference

  Oral presentation


• 肺腺癌におけるPSF3発現の臨床的意義の検討

  Hokka Daisuke, Maniwa Yoshimasa, Tane Shinya, Tauchi Shunsuke

  第113回日本外科学会, Apr. 2013, Japanese, 日本外科学会, 福岡, Domestic conference

  Oral presentation


• がん細胞の浸潤転移機構の解明と治療への展開 肺腺癌浸潤におけるNecl-5の働きについての検討

  Tane Shinya, Maniwa Yoshimasa, Hokka Daisuke, Tauchi Shunsuke

  第113回日本外科学会, Apr. 2013, Japanese, 日本外科学会, 福岡, Domestic conference

  Oral presentation


• 吸気呼気CTによる肺気腫の定量評価

  Nishio Mizuho, Matsumoto Sumiaki, Koyama Hisanobu, Ohno Yoshiharu, Maniwa Yoshimasa, Kotani Yoshikazu, Nishimura Yoshihiro, Sugimura Kazuro

  第5回日本呼吸機能イメージング研究会学術集会, Jan. 2013, Japanese, 日本呼吸機能イメージング研究会, 徳島, Domestic conference

  Poster presentation


• Utility of Whole-Body Contrast-Enhanced Quick 3D for Distance Metastasis and Recurrence Assessment in Lung Cancer Patients

  Ohno Yoshiharu, 関 紳一郎, Koyama Hisanobu, Kotani Yoshikazu, Maniwa Yoshimasa, Sugimura Kazuro

  53th Annual Meeting of The Japan Lung Cancer Society, Nov. 2012, Japanese, The Japan Lung Cancer Society, 岡山, Domestic conference

  Oral presentation


• 当科における傍腫瘍性神経症候群合併小細胞肺癌の臨床的検討

  Tachihara Motoko, 堀 朱矢, 畠山 由記久, Tamura Daisuke, 永野 達也, 櫨木 暢子, Kasai Daisuke, Funada Yasuhiro, Kotani Yoshikazu, Sakai Yasuhiro, Ohno Yoshiharu, Maniwa Yoshimasa, Nishimura Yoshihiro

  第53回日本肺癌学会総会, Nov. 2012, Japanese, The Japan Lung Cancer Society, 岡山, Domestic conference

  Poster presentation


• ALK染色陽性肺腺癌の術前診断の可能性

  Sakai Yasuhiro, 大林 千穂, 中井 登紀子, Ohno Yoshiharu, Funada Yasuhiro, Kotani Yoshikazu, Nishimura Yoshihiro, Tane Shinya, Tauchi Shunsuke, Maniwa Yoshimasa, 佐久間 淑子, 竹中 大祐, 足立 秀治, 里内 美弥子, 根來 俊一, 小川 裕行, 多根 健太, 内野 和哉, 西尾 渉, 吉村 雅裕

  第53回日本肺癌学会総会, Nov. 2012, Japanese, The Japan Lung Cancer Society, 岡山, Domestic conference

  Poster presentation


• Adaptive Iterative Dose Reduction using Three Dimensional Processing (AIDR 3D) for Radiation Dose Reduction for Chest CT Examination

  Ohno Yoshiharu, 関 紳一郎, Koyama Hisanobu, Yoshikawa Takeshi, Kotani Yoshikazu, Maniwa Yoshimasa, Sugimura Kazuro

  53th Annual Meeting of The Japan Lung Cancer Society, Nov. 2012, Japanese, The Japan Lung Cancer Society, 岡山, Domestic conference

  Oral presentation


• 術待機中に空洞形成を伴った非定型的肺カルチノイドの一例

  山崎 晴菜, Nishio Mizuho, 関 紳一郎, Koyama Hisanobu, Ohno Yoshiharu, Sakai Yasuhiro, Maniwa Yoshimasa, Nishimura Yoshihiro, Itoh Tomoo, Sugimura Kazuro

  第48回日本医学放射線学会秋季臨床大会, Sep. 2012, Japanese, Japan Radiological Society, 長崎, Domestic conference

  Poster presentation


• Sirt1 is a tumor promoter in lung adenocarcinoma

  陳 雪, Maniwa Yoshimasa, Hayashi Yoshitake

  71th annual congress of Japanese Cancer Association, Sep. 2012, English, Japan Cancer Association, 札幌, Domestic conference

  Oral presentation


• Slug Increases Sensitivity To Tubulin Binding Agents Via The Downregulation Of Beta III And IVa-Tubulin In Lung Cancer Cells

  Tamura Daisuke, Tokuzo Arao, Tomoyuki Nagai, Hiroyasu Kaneda, Kanae Kudo, Keiichi Aomatsu, Kazuko Sakai, Yasuhiko Fujita, Kazuko Matsumoto, Marco A. De Velasco, Hideharu Kimura, Daisuke Hokke, Kobayashi Kazuyuki, Maniwa Yoshimasa, Wataru Nishio, Kotani Yoshikazu, Nishimura Yoshihiro, Nagahiro Saijo, Kazuto Nishio

  Amarican Thoracic Society Internatinal Conference 2012, May 2012, English, Amarican Thoracic Society, San Francisco, USA, Epithelial-Mesenchymal Transition (EMT) has been classified as a unique process by which epithelial cells undergo mesenchymal phenotype leading to increased motility and invasion. The aim of this study was to elucidate the biological functions of Slug/Sna, International conference

  Poster presentation


• 非小細胞肺癌リンパ節転移の定量的診断能; 3T-MRI STIR vs. 1.5T-MRI STIR vs. PET/CT

  竹中大祐, Koyama Hisanobu, 尾西由美子, Nishio Mizuho, Matsumoto Sumiaki, Kotani Yoshikazu, Maniwa Yoshimasa, 西尾 渉, Ohno Yoshiharu, Sugimura Kazuro

  第52回肺癌学会総会, Nov. 2011, Japanese, 肺癌学会, 大阪, Domestic conference

  Poster presentation


• Quantitative Perfusion CT using 320-Detector Row CT: Differentiation of Malignant from Benign Nodules as Compared with Dynamic MRI and PET/CT

  Ohno Yoshiharu, Nishio Mizuho, 尾西由美子, Koyama Hisanobu, 竹中大祐, Kotani Yoshikazu, Maniwa Yoshimasa, Itoh Tomoo, 西尾 渉, Nishimura Yoshihiro, Sugimura Kazuro

  第52回日本肺癌学会総会, Nov. 2011, Japanese, 日本肺癌学会, 大阪, Domestic conference

  Oral presentation


• FDG-PET/CTにて異常集積を認めた混合性胚細胞腫瘍の一例

  尾西由美子, Ohno Yoshiharu, 竹中大祐, Matsumoto Sumiaki, Kotani Yoshikazu, Maniwa Yoshimasa, 西村善弘, 西尾渉, 大林千穂, Sugimura Kazuro

  第51回肺癌学会総会, Nov. 2010, Japanese, 日本肺癌学会, 広島, Domestic conference

  Poster presentation


• 転移性肺腫瘍に対する放射線治療後のサルベージ手術

  Maniwa Yoshimasa, Hashimoto Shotaro, Nishio Wataru

  第17回関西転移性肺腫瘍研究会, Mar. 2010, Japanese, 大阪, Domestic conference

  Oral presentation


• 頚部から胸腔内に及ぶ巨大desmoidの１切除例

  Hashimoto Shotaro, Maniwa Yoshimasa, Nishio Wataru

  第42回兵庫呼吸器外科研究会, Mar. 2010, Japanese, 神戸, Domestic conference

  Oral presentation


• 胸腔鏡下区域切除術における区域間処理の工夫

  Nishio Wataru, Hashimoto Shotaro, Maniwa Yoshimasa

  第22回近畿胸腔鏡研究会, Mar. 2010, Japanese, 日本呼吸器外科学会, 京都, Domestic conference

  Oral presentation


• cT1N3M0原発性肺癌を疑い、診断目的に切除した肺腫瘤の１例

  Hashimoto Shotaro, Maniwa Yoshimasa, Nishio Wataru, Funada Yasuhiro, Kotani Yoshikazu, Nishimura Yoshihiro, Takenaka Daisuke, Ohno Yoshiharu, Itoh Tomoo

  第105回兵庫県肺癌懇話会, Mar. 2010, Japanese, 神戸, Domestic conference

  Oral presentation


• 胸腔鏡下に切除した後縦隔発生Ｃastleman病の１例

  Hashimoto Shotaro, Maniwa Yoshimasa, Nishio Wataru, Funada Yasuhiro, Kotani Yoshikazu, Nishimura Yoshihiro, Takenaka Daisuke, Ohno Yoshiharu, Uehara Keiichiro, Itoh Tomoo

  第91回日本肺癌学会関西支部会, Jan. 2010, Japanese, 日本肺癌学会, 大津, Domestic conference

  Oral presentation


• 肺結核合併肺癌の1手術例

  Hashimoto Shotaro, Maniwa Yoshimasa, Nishio Wataru, Funada Yasuhiro, Kotani Yoshikazu, Nishimura Yoshihiro, Takenaka Daisuke, Ohno Yoshiharu, Ohbayashi Chiho, Itoh Tomoo

  第104回兵庫県肺癌懇話会, Dec. 2009, Japanese, 神戸,, Domestic conference

  Oral presentation


• 肺腺癌におけるNecl-5発現の意義

  Maniwa Yoshimasa, Hashimoto Shotaro, Nishio Wataru, Kotani Yoshikazu, Nishimura Yoshihiro, Takenaka Daisuke, Ohno Yoshiharu, Ohbayashi Chiho

  第50回日本肺癌学会総会, Nov. 2009, Japanese, 日本肺癌学会, 東京, Domestic conference

  Poster presentation


• 左側肺癌リンパ節郭清

  Nishio Wataru, Hashimoto Shotaro, Maniwa Yoshimasa

  第10回近畿呼吸器外科手術手技研究会, Nov. 2009, Japanese, 大阪, Domestic conference

  Oral presentation


• 320列面検出器CTによるFirst-Pass Perfusion CT vs. FDG-PET/CT: 肺結節の良･悪性鑑別診断能に関する検討

  Ohno Yoshiharu, 尾西由美子, 松本敬子, Koyama Hisanobu, 野上宗伸, 竹中大祐, Kotani Yoshikazu, Maniwa Yoshimasa, 西尾 渉, Nishimura Yoshihiro, 大林千穂, Sugimura Kazuro

  第50回日本肺癌学会総会, Nov. 2009, Japanese, 日本肺癌学会, 東京, Domestic conference

  Oral presentation


• 広汎な胸壁浸潤をきたしたSeperior sulcus tumorに対する前方（trans-manubrial）・後方アプローチの有用性

  Nishio Wataru, Hashimoto Shotaro, Maniwa Yoshimasa

  第62回日本胸部外科学会定期学術集会, Oct. 2009, Japanese, 日本胸部外科学会, 横浜, Domestic conference

  Oral presentation


• DNA damage sensor protein hRad9 - A novel molecular target for lung cancer treatment

  Maniwa Yoshimasa

  14th World Congress on Advances in Oncology, Oct. 2009, English, ロートラキ, ギリシャ, International conference

  [Invited]

  Invited oral presentation


• B型肝炎性肝細胞癌にて肝移植後に発症した転移性肺腫瘍に対する1手術例

  Hashimoto Shotaro, Maniwa Yoshimasa, Nishio Wataru, Funada Yasuhiro, Kotani Yoshikazu, Nishimura Yoshihiro, Takenaka Daisuke, Ohno Yoshiharu, Ohbayashi Chiho, Itoh Tomoo

  第90回日本肺癌学会関西支部会, Jul. 2009, Japanese, 日本肺癌学会, 大阪, Domestic conference

  Oral presentation


• Modified hemi-clamshell approachによるChronic expanding hematomaの１手術例

  Nishio Wataru, Maniwa Yoshimasa

  第52回関西胸部外科学会学術集会, Jun. 2009, Japanese, 日本胸部外科学会, 岡山, Domestic conference

  Oral presentation


• 断端再発のリスクを考慮した部分切除術法（露天掘り法）

  Nishio Wataru, Maniwa Yoshimasa

  第26回日本呼吸器外科学会総会, May 2009, Japanese, 日本呼吸器外科学会, 北九州, Domestic conference

  Poster presentation


• 原発性肺線癌におけるNecl-5発現の検討

  Maniwa Yoshimasa, Nishio Wataru

  第26回日本呼吸器外科学会総会, May 2009, Japanese, 日本呼吸器外科学会, 北九州, Domestic conference

  Poster presentation


• 下降性壊死性縦隔炎に対する経胸腔アプローチによる縦隔ドレナージ術

  Maniwa Yoshimasa, Nishio Wataru

  第9回近畿呼吸器外科手術手技研究会, Apr. 2009, Japanese, 大阪, Domestic conference

  Oral presentation


• Damage repair pathwayにおけるNon-synonymous SNPsと肺腺癌の発生についての検討

  Maniwa Yoshimasa, Nishio Wataru

  第109回日本外科学会定期学術集会, Apr. 2009, Japanese, 日本外科学会, 福岡, Domestic conference

  Poster presentation


• 非小細胞肺癌患者における全身FDG-PET/CTの術後再発診断能に関する検討

  Onishi Yumiko, Ohno Yoshiharu, Nogami Munenobu, Kouyama Hisanobu, Matsumoto Sumiaki, Takenaka Daisuke, Kotani Yoshikazu, Maniwa Yoshimasa, Nishio Wataru, Ohbayashi Chiho, Nishimura Yoshihiro, Sugimura Kazuro

  第49回日本肺癌学会総会, Nov. 2008, Japanese, 日本肺癌学会, 北九州, Domestic conference

  Oral presentation


• 胸部MRIにおける肺腺癌の結節同定能と組織分類の検討 拡散強調像とSTIR像の比較

  Kouyama Hisanobu, Ohno Yoshiharu, Onishi Yumiko, Nogami Munenobu, Takenaka Daisuke, Kotani Yoshikazu, Maniwa Yoshimasa, Nishio Wataru, Ohbayashi Chiho, Nishimura Yoshihiro, Sugimura Kazuro

  第49回 日本肺癌学会総会, Nov. 2008, Japanese, 日本肺癌学会, 北九州市, Domestic conference

  Oral presentation


• Dynamic MRI vs. CT vs. RI：非小細胞肺癌患者の術後肺機能予測能に関する検討

  Ohno Yoshiharu, Onishi Yumiko, Kouyama Hisanobu, Nogami Munenobu, Takenaka Daisuke, Kotani Yoshikazu, Maniwa Yoshimasa, Nishio Wataru, Nishimura Yoshihiro, Sugimura Kazuro

  第49回日本肺癌学会総会, Nov. 2008, Japanese, 日本肺癌学会, 北九州, Domestic conference

  Poster presentation


• Dynamic MRI vs.CT vs.RI 非小細胞肺癌患者の術後肺機能予測能に関する検討

  Ohno Yoshiharu, Onishi Yumiko, Kouyama Hisanobu, Nogami Munenobu, Takenaka Daisuke, Matsumoto Sumiaki, Kotani Yoshikazu, Maniwa Yoshimasa, Nishio Wataru, Nishimura Yoshihiro, Sugimura Kazuro

  •第49回 日本肺癌学会総会, Nov. 2008, Japanese, 日本肺癌学会, 北九州市, Domestic conference

  Oral presentation


• 悪性胸膜中皮腫の外科治療：手術成績と今後の戦略

  Maniwa Yoshimasa, Nishio Wataru, Tauchi Shunsuke

  第61回 日本胸部外科学会定期学術集会, Oct. 2008, Japanese, 日本胸部外科学会, 福岡, Domestic conference

  Public symposium


• The interval for re-evaluation of foci is necessary prior to pulmonary metastasectomy

  Maniwa Yoshimasa, Nishio Wataru

  Chest 2008, Oct. 2008, English, American College of Chest Physician, フィラデルフィア, 米国, International conference

  Poster presentation


• Poor Risk肺癌症例に対するSub-lobar Resectionの妥当性

  Nishio Wataru, Maniwa Yoshimasa

  第61回 日本胸部外科学会定期学術集会, Oct. 2008, Japanese, 日本胸部外科学会, 福岡, Domestic conference

  Oral presentation


• 腫瘍随伴性小脳変性症(PCD)を合併した小細胞肺癌の1例

  Maniwa Yoshimasa, Nishio Wataru

  第88回 日本肺癌学会関西支部会, Jul. 2008, Japanese, 日本肺癌学会, 大阪, Domestic conference

  Oral presentation


• 下降性壊死性縦隔炎に対する頚部切開および開胸による縦隔ドレナージ

  Maniwa Yoshimasa, Nishio Wataru

  第51回 関西胸部外科学会学術集会, Jun. 2008, Japanese, 日本胸部外科学会, 富山, Domestic conference

  Public symposium


• 非小細胞肺癌におけるFOXO1発現の意義

  Maniwa Yoshimasa, Nishio Wataru

  第25回 日本呼吸器外科学会総会, May 2008, Japanese, 日本呼吸器外科学会, 宇都宮, Domestic conference

  Poster presentation


• 転移性肺腫瘍に対する粒子線治療後のサルベージ手術

  Nishio Wataru, Maniwa Yoshimasa

  第25回 日本呼吸器外科学会総会, May 2008, Japanese, 日本呼吸器外科学会, 宇都宮, Domestic conference

  Poster presentation


• 下降性壊死性縦隔炎に対する徹底的な縦隔ドレナージ術

  Maniwa Yoshimasa, Nishio Wataru

  第25回 日本呼吸器外科学会総会, May 2008, Japanese, 日本呼吸器外科学会, 宇都宮, Domestic conference

  Oral presentation


• 腫瘍随伴性小脳変性症(PCD)を合併した小細胞肺癌の1例

  Maniwa Yoshimasa, Nishio Wataru, Funada Yasuhiro, Kotani Yoshikazu, Nishimura Yoshihiro, Kouyama Hisanobu, Takenaka Daisuke, Ohno Yoshiharu, Ohbayashi Chiho

  第99回 兵庫肺癌懇話会, Mar. 2008, Japanese, 神戸, Domestic conference

  Oral presentation


• 放射線診断と治療の最前線 肺癌患者におけるM因子診断における全身脂肪抑制併用拡散強調画像の有用性に関する検討

  Ohno Yoshiharu, Onishi Yumiko, Kouyama Hisanobu, Nogami Munenobu, Takenaka Daisuke, Matsumoto Sumiaki, Kotani Yoshikazu, Maniwa Yoshimasa, Nishio Wataru, Nishimura Yoshihiro, Ohbayashi Chiho, Sugimura Kazuro

  第48回日本肺癌学会総会, Nov. 2007, Japanese, 日本肺癌学会, 名古屋, Domestic conference

  [Invited]

  Invited oral presentation


• 非造影MRIを用いた肺末梢結節スクリーニング能の検討

  Kouyama Hisanobu, Ohno Yoshiharu, Onishi Yumiko, Nogami Munenobu, Matsumoto Sumiaki, Takenaka Daisuke, Kotani Yoshikazu, Maniwa Yoshimasa, Nishio Wataru, Ohbayashi Chiho, Nishimura Yoshihiro, Sugimura Kazuro

  第48回日本肺癌学会総会, Nov. 2007, Japanese, 日本肺癌学会, 名古屋, Domestic conference

  Oral presentation


• Assessement of Non-contrast-enhanced MRI for Lung Cancer Screening

  Kouyama Hisanobu, Ohno Yoshiharu, Onishi Yumiko, Nogami Munenobu, Matsumoto Sumiaki, Takenaka Daisuke, Kotani Yoshikazu, Maniwa Yoshimasa, Nishio Wataru, Ohbayashi Chiho, Nishimura Yoshihiro, Sugimura Kazuro

  第48回日本肺癌学会総会, Nov. 2007, Japanese, 日本肺癌学会, 名古屋, Domestic conference

  Oral presentation


• 非小細胞肺癌患者の術後肺機能予測に関する検討：Perfusion MRI，造影MSCT及び肺血流SPECTの対比

  Ohno Yoshiharu, Kouyama Hisanobu, Nogami Munenobu, Takenaka Daisuke, Matsumoto Sumiaki, Kotani Yoshikazu, Maniwa Yoshimasa, Nishio Wataru, Nishimura Yoshihiro, Sugimura Kazuro

  第48回日本肺癌学会総会, Nov. 2007, Japanese, 日本肺癌学会, 名古屋, Domestic conference

  Poster presentation


• 非小細胞肺癌患者の術後肺機能予測に関する検討 Dynamic Perfusion MRI、MDCT及び肺血流SPECTの対比

  Ohno Yoshiharu, Onishi Yumiko, Kouyama Hisanobu, Nogami Munenobu, Takenaka Daisuke, Matsumoto Sumiaki, Kotani Yoshikazu, Maniwa Yoshimasa, Nishio Wataru, Nishimura Yoshihiro, Sugimura Kazuro

  第48回日本肺癌学会総会, Nov. 2007, Japanese, 日本肺癌学会, 名古屋, Domestic conference

  Poster presentation


• 肺癌患者におけるM因子診断における全身脂肪抑制併用拡散強調画像の有用性に関する検討

  Ohno Yoshiharu, Onishi Yumiko, Kouyama Hisanobu, Nogami Munenobu, Matsumoto Sumiaki, Takenaka Daisuke, Kotani Yoshikazu, Maniwa Yoshimasa, Nishio Wataru, Nishimura Yoshihiro, Ohbayashi Chiho, Sugimura Kazuro

  第48回日本肺癌学会総会, Nov. 2007, Japanese, 日本肺癌学会, 名古屋, Domestic conference

  Public symposium


• 肺癌の肺門部気管支血管周囲組織浸潤と断端および予後に関する検討(続報)

  Sakai Yasuhiro, Ohbayashi Chiho, Kotani Yoshikazu, Nishimura Yoshihiro, Satouchi Miyako, Maniwa Yoshimasa, Nishio Wataru, Ohno Yoshiharu

  第48回日本肺癌学会総会, Nov. 2007, Japanese, 日本肺癌学会, 名古屋, Domestic conference

  Poster presentation


• 術後補助化学療法としてのCDDP+VNRの安全性と有用性の検討

  Kotani Yoshikazu, Funada Yasuhiro, Nishimura Yoshihiro, Maniwa Yoshimasa, Nishio Wataru, Takenaka Daisuke, Ohno Yoshiharu, Ohbayashi Chiho

  第48回日本肺癌学会総会, Nov. 2007, Japanese, 日本肺癌学会, 名古屋, Domestic conference

  Poster presentation


• 悪性胸膜中皮腫(MPM)手術例の検討

  Tauchi Shunsuke, Satouchi Miyako, Ohbayashi Chiho, Nishio Wataru, Maniwa Yoshimasa, Ohno Yoshiharu, Kotani Yoshikazu, Nishimura Yoshihiro

  第48回日本肺癌学会総会, Nov. 2007, Japanese, 日本肺癌学会, 名古屋, Domestic conference

  Public symposium


• PET/CTによる非小細胞肺癌術後患者の再発予測

  Takenaka Daisuke, Ohno Yoshiharu, Onishi Yumiko, Kouyama Hisanobu, Nogami Munenobu, Matsumoto Sumiaki, Kotani Yoshikazu, Maniwa Yoshimasa, Nishio Wataru, Ohbayashi Chiho, Nishimura Yoshihiro, Sugimura Kazuro

  第48回日本肺癌学会総会（名古屋）, Nov. 2007, Japanese, 日本肺癌学会, 名古屋, Domestic conference

  Public symposium


• FDG-PETの意義と応用 非小細胞肺癌術後患者における切除断端部再発 FDG-PET/CTと造影CTの診断能比較

  Onishi Yumiko, Ohno Yoshiharu, Kouyama Hisanobu, Nogami Munenobu, Matsumoto Sumiaki, Takenaka Daisuke, Kotani Yoshikazu, Maniwa Yoshimasa, Nishio Wataru, Ohbayashi Chiho, Nishimura Yoshihiro, Sugimura Kazuro

  第48回日本肺癌学会総会, Nov. 2007, Japanese, 日本肺癌学会, 名古屋, Domestic conference

  Public symposium


• FDG-PETの意義と応用 PET/CTによる非小細胞肺癌術後患者の再発予測

  Takenaka Daisuke, Ohno Yoshiharu, Onishi Yumiko, Kouyama Hisanobu, Nogami Munenobu, Matsumoto Sumiaki, Kotani Yoshikazu, Maniwa Yoshimasa, Nishio Wataru, Ohbayashi Chiho, Nishimura Yoshihiro, Sugimura Kazuro

  第48回日本肺癌学会総会, Nov. 2007, Japanese, 日本肺癌学会, 名古屋, Domestic conference

  Public symposium


• BAC cell浸潤におけるTumor-host interfaceの役割に関しての実験的検討

  Maniwa Yoshimasa, Nishio Wataru, Ohbayashi Chiho

  第48回日本肺癌学会総会, Nov. 2007, Japanese, 日本肺癌学会, 名古屋, Domestic conference

  Others


• Poor risk肺癌症例に対する縮小手術の妥当性

  Nishio Wataru, Maniwa Yoshimasa

  第60回日本胸部外科学会総会, Oct. 2007, Japanese, 日本胸部外科学会, 仙台, Domestic conference

  Oral presentation


• In-vitro visualization of cancer-stroma interaction in bronchiolo-alveolar carcinoma with invasive component

  Maniwa Yoshimasa, Nishio Wataru, Hayashi Yoshitake, Okita Yutaka

  Chest2007, Oct. 2007, English, American College of Chest Physicians, シカゴ, 米国, International conference

  Public symposium


• In-vitro visualization of cancer-stroma interaction in bronchiolo-alveolar carcinoma (BAC) with invasive component

  Maniwa Yoshimasa, Nishio Wataru, Ohbayashi Chiho

  第66回日本癌学会総会, Oct. 2007, Japanese, 日本癌学会, 横浜, Domestic conference

  Poster presentation


• 大量喀血を契機に発見された肺肉腫様癌の1例

  Funada Yasuhiro, Kotani Yoshikazu, Nishimura Yoshihiro, Maniwa Yoshimasa, Ohbayashi Chiho

  第69回日本呼吸器学会近畿地方会, Jun. 2007, Japanese, 日本呼吸器学会近畿支部, 大阪, Domestic conference

  Oral presentation


• 原発性気管癌に対して緊急手術を施行した2例

  Maniwa Yoshimasa, Okita Yutaka

  第24回日本呼吸器外科学会総会, May 2007, Japanese, 日本呼吸器外科学会, 横浜, Domestic conference

  Oral presentation


• 家族性多発性内分泌腺腫症の精査中に巨大縦隔腫瘍を指摘され胸腺カルチノイドと診断された一例

  Maniwa Yoshimasa

  第24回日本呼吸器外科学会総会, May 2007, Japanese, 日本呼吸器外科学会, 横浜, Domestic conference

  Poster presentation


• 右主気管支内腔を鋳型状に発育・閉塞した右下葉原発筋上皮癌の1例

  Maniwa Yoshimasa, Ohbayashi Chiho, Okita Yutaka

  第24回日本呼吸器外科学会総会, May 2007, Japanese, 日本呼吸器外科学会, 横浜, Domestic conference

  Poster presentation


• Chemosensitivity of lung cancer: difference between primary tumor and metastatic lymph node

  Yoshimasa Maniwa

  CHEST2006, Oct. 2006, English, American College of Chest Physician, Solt Lake City, Utah, USA, International conference

  Poster presentation


• 肺癌におけるDNA damage sensor蛋白Rad9発現の意義

  MANIWA, Yoshimasa, YOSHIMURA, Masahiro, 湯木 毅, OHBAYASHI, Chiho, HAYASHI, Yoshitake, OKITA, Yutaka

  第64回日本癌学会総会, Sep. 2005, Japanese, 日本癌学会, 札幌, Domestic conference

  Poster presentation


• 孤立性肺転移で発見された不顕性甲状腺乳頭癌の1例

  野田 尚子, 藤本 昌代, OHBAYASHI, Chiho, 松岡 亮, 竹田 隆之, 坂下 明大, 高橋 愛, 上領 博, 竹中 かおり, 浦田 佳子, 島田 天美子, 小林 和幸, 西馬 照明, SATOUCHI, Miyako, NISHIMURA, Yoshihiro, 東野 貴徳, 野上 宗伸, OHNO, Yoshiharu, 内野 和哉, MANIWA, Yoshimasa, YOSHIMURA, Masahiro, INOUE, Hiroyuki

  日本肺癌学会関西支部会（第82回）, Jul. 2005, Japanese, 日本肺癌学会, 神戸, Domestic conference

  Oral presentation


• 転写調節因子による腫瘍の表現形質と悪性度の修飾 細胞周期制御蛋白p21およびその転写活性化因子の発現異常 肺腺癌における表現形質と悪性度の変化

  MANIWA, Yoshimasa, YOSHIMURA, Masahiro, OKITA, Yutaka, KANOMATA, Naoki, OHBAYASHI, Chiho, 埴岡 啓介, Hurwitz Jerard, HAYASHI, Yoshitake

  第９４回日本病理学会総会, Apr. 2005, Japanese, 日本病理学会, 横浜, Domestic conference

  Public symposium


• 細胞周期制御蛋白p21およびその転写活性化因子の発現異常-肺腺癌における表現形質と悪性度の変化

  MANIWA, Yoshimasa, YOSHIMURA, Masahiro, OKITA, Yutaka, KANOMATA, Naoki, OHBAYASHI, Chiho, 埴岡 啓介, Hurwitz Jerard, HAYASHI, Yoshitake

  第９４回日本病理学会総会, Apr. 2005, Japanese, 日本病理学会, 横浜, Domestic conference

  Public symposium


• 原発性肺腺癌におけるp53発現異常と細胞分裂能の関連性

  MANIWA, Yoshimasa, YOSHIMURA, Masahiro, 原田 直樹, 高田昌彦, 岩永 幸一郎, 湯木 毅, 三村 剛史, 内野 和哉, OKITA, Yutaka, SATOUCHI,Miyako, NISHIMURA, Yoshihiro, 東野 貴徳, OHNO, Yoshiharu, OHBAYASHI, Chiho

  第45回日本肺癌学会総会, Nov. 2004, Japanese, 横浜, Domestic conference

  Oral presentation


• STIR Turbo SE MRI vs. FDG-PET: 非小細胞肺癌における術前転移リンパ節診断能の比較

  OHNO, Yoshiharu, 野上 宗伸, 東野 貴徳, TAKENAKA, Daisuke, MATSUMOTO, Sumiaki, MANIWA, Yoshimasa, SATOUCHI, Miyako, NISHIMURA, Yoshihiro, 大林 加代子, OHBAYASHI, Chiho, YOSHIMURA, Masahiro, SUGIMURA, Kazuro

  第45回日本肺癌学会総会, Nov. 2004, Japanese, 日本肺癌学会, 横浜, Domestic conference

  Oral presentation


• MRIによる肺癌検診の有用性に関する検討

  TAKENAKA, Daisuke, OHNO, Yoshiharu, 東野 貴徳, 野上 宗伸, MANIWA, Yoshimasa, YOSHIMURA, Masahiro, SATOUCHI, Miyako, NISHIMURA, Yoshihiro, OHBAYASHI, Chiho, 大林 加代子, SUGIMURA, Kazuro

  2004.10.25 第45回日本肺癌学会総会（横浜）, Oct. 2004, Japanese, 日本肺癌学会, 横浜, Domestic conference

  Oral presentation


• hRad9蛋白質の生物学的特性と癌細胞における機能

  MANIWA, Yoshimasa, YOSHIMURA, Masahiro, 原田直樹, 高田昌彦, 岩永幸一郎, 湯木毅, 三村剛史, 内野和哉, OKITA, Yutaka, OHBAYASHI, Chiho, ブラディミア・バミューデス, ジェラルド・ハービッツ, HAYASHI, Yoshitake

  第63回日本癌学会総会, Sep. 2004, Japanese, 日本癌学会, 福岡, Domestic conference

  Poster presentation

• American Society of Clinical Oncology


• American Association for Thoracic Surgery


• 日本医療マネジメント学会


• 日本レーザー医学会


• 日本気胸・嚢胞性肺疾患学会


• 日本気管食道科学会


• American College of Chest Physician


• 日本肺癌学会


• 日本癌治療学会


• 日本癌学会


• 日本外科学会


• 日本胸部外科学会


• 日本呼吸器外科学会

• Study of Progression and Anticancer Drug Sensitivity in an Orthotopic Transplantation Mouse Model Using Lung Cancer Organoids

  眞庭 謙昌, 青井 貴之

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Kobe University, Apr. 2025 - Mar. 2028, Principal investigator


• Establishment of lung cancer organoids and their practical application in clinical practice

  眞庭 謙昌, 青井 貴之, 法華 大助

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Fund for the Promotion of Joint International Research (Fostering Joint International Research (B)), Kobe University, Oct. 2020 - Mar. 2025, Principal investigator

  人工肺癌オルガノイドを孵卵開始後10日目の漿尿膜上に移植したところ、細胞ペレットとして移植した細胞群が翌日には１箇所に集簇し、移植後５日目には移植部位周囲は肉眼的に明らかに肥厚したnestを形成し、それを取り囲むように太い血管が存在し、周囲、移植片の表面には蛇行するらせん状の血管を無数に認めた。この血管を超高感度カメラで観察したところ、太い血管から無数の血管が分岐し、それぞれが腫瘍から血流が流入、流出していることが確認できた。また。それらの細枝は、各々が蛇行し微細な血管によって連結し毛細血管網を形成していた。肺癌細胞株(A549)を移植したものと比較し、人工肺癌オルガノイドを移植したものでは組織が明らかに肥厚しており、膜上に明らかなmassを形成し、漿尿膜の構造を破壊し、膜内に浸潤している様子が確認できた。 また、免疫組織化学で、ヒト由来の細胞のみを染色すると、漿尿膜内に存在し、一部増殖、浸潤を疑う形態を示すオルガノイドを認めた。以上から、鶏卵漿尿膜培養は、浸潤や血管新生を含む癌‐宿主相互作用を評価することが可能で、ヒトの癌病巣でみられる病態を模倣した現象を5日間で誘導できることが明らかになった。また、化学療法感受性試験についても検討した。人工肺癌オルガノイドを３日間漿尿膜上で培養後、殺細胞性抗癌剤であるシスプラチンを滴下し２日間培養したところ、人工肺癌オルガノイドは白色に変化し、周囲の血流もなくなり壊死していることが確認できた。しかし、何も移植していない漿尿膜に同様の実験を行ったところ、滴下部位の周囲の血管が白色に変化し、漿尿膜も壊死していたことから、シスプラチンが人工肺癌オルガノイドのみに作用し壊死したとは考えにくく、漿尿膜も含め作用したことにより壊死したのではないかと考えられた。


• Establishment of phenotype based precision medicine for mediastinal primary sarcoma using iPS technology

  田中 雄悟, 青井 貴之, 眞庭 謙昌

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2021 - 31 Mar. 2024

  当院で2008年から2021年までに切除された縦隔原発肉腫20例についての予後因子、治療効果因子を探索するために、切除標本を用い検討を行うこととした。組織型については肺動脈内膜肉腫；12例（うち2例は同一症例での再発時の検体を使用）、脂肪肉腫；5例、平滑筋肉腫；1例、骨外性骨肉腫；1例、Sarcoma NOS；1例であった。 まず、腫瘍のPD-L1発現の有無を確認するために未染組織ブロックより薄切標本を作製し、腫瘍細胞のPDL-1タンパクの発現の有無を調べた。結果については、すべての組織検体において発現は低発現（5%以下）であった。 引き続き、同腫瘍のパラフィンブロックよりDNA及びRNAを抽出を試みた。20検体中の2検体で組織量が少なく抽出が少ない可能性が示唆されたが、現在20例全てにおいて抽出を進めているところである。RNA抽出の状況を確認し、可能なサンプルに関しては、引き続きNext Generation Sequencer (NGS)にてRNA-Seq解析及びExome解析を行っていく。結果については今後、ライブラリーのデータを用い癌関連遺伝子を始めとした約3万種類の遺伝子について縦隔肉腫組織内で特異的に高発現している遺伝子を確認する予定である。 また、同時並行で計画していた「軟部肉腫オルガノイド作成と漿尿膜培養による肉腫オルガノイドの微小環境の評価」については昨年度に肺動脈内膜肉腫について1例の外科治療症例があったため、切除直後の腫瘍組織を採取し、人工軟部肉腫幹細胞の作製を試みた。しかし、腫瘍細胞周囲の間質細胞の量が上皮系悪性腫瘍と比較し著明に多く、オルガノイド作成には至らなかった。


• Investigation of the potential candidate gene in cancer cell invasion using cancer cell lines and 3-D in vitro model

  Doi Takefumi

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2019 - 31 Mar. 2022

  Invasion has a significant role in cancer progression and metastasis. Previously, we assessed the invasive ability of cancer cells using an easy to prepare double layered collagen gel hemisphere (DL-CGH) method by which cancer cell invasion can be easily visualized. The present study examined multiple lung adenocarcinoma and malignant pleural mesothelioma (MPM) cell lines using the DL-CGH method and identified inherently invasive cell lines. Next, by comparing gene expression between invasive and noninvasive cells by cDNA microarray, the potential candidate gene brain-expressed x-linked protein 1 (Bex1) was identified to be involved in cancer invasion, as it was highly expressed in the invasive cell lines. Downregulation of Bex1 suppressed the invasion and proliferation of the invasive tumor cell lines. The findings of the present study suggested that Bex1 may promote metastasis in vivo and could be a potential oncogene and molecular therapeutic target in lung adenocarcinoma and MPM.


• A novel cancer immunotherapy focused on organ specific immune memory generation

  Yamashita Kimihiro

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2019 - 31 Mar. 2022

  This study shows the potential of a novel dendritic cell vaccine therapy in antitumor immunity, in which bone marrow-derived dendritic cells are electroporated with an exogenous ovalbumin protein and simultaneously pulsed with α-galactosylceramide. This strategy enhances the induction of cytotoxic CD8+ T cells specific for tumor-associated antigens through the activation of invariant natural killer T cells, natural killer cells, and intrinsic dendritic cells. Moreover, this strategy sustains antigen-specific antitumor T cell responses over time.


• A study on endoscopic surgery support system by using multiple cameras

  Morimoto Masakazu

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), University of Hyogo, 01 Apr. 2019 - 31 Mar. 2022

  Video-assisted thoracoscopic surgery has been shown to be safer and smoother by adding a second camera to the traditional procedure of using one endoscopic camera. By fixing the second camera to the upper part of the thoracic cavity and installing it so that the surgical field can be photographed with a bird's-eye view, the above effects can be obtained without burdening doctors and surgical assistants.


• 肺大細胞神経内分泌癌の抗癌剤感受性における神経内分泌因子の役割

  田中 雄悟

  学術研究助成基金助成金／基盤研究(C), Apr. 2018 - Mar. 2021

  Competitive research funding


• AIによる肺癌超低線量CT検診及び肺結節鑑別診断用コンピューター支援装置開発

  竹中 大祐

  学術研究助成基金助成金／基盤研究(C), Apr. 2018 - Mar. 2021

  Competitive research funding


• 人工癌幹細胞技術を用いた肺腺癌浸潤部位形成のメカニズムとその制御法の研究

  眞庭 謙昌

  科学研究費補助金／基盤研究(B), Apr. 2017 - Mar. 2020, Principal investigator

  Competitive research funding


• 超短エコー時間核磁気共鳴画像法を用いた新たな肺形態・機能画像診断法の開発

  大野 良治

  学術研究助成基金助成金／基盤研究(C), Apr. 2015 - Mar. 2018

  Competitive research funding


• 肺腺癌浸潤における癌幹細胞の役割についてのiPS細胞技術を用いた研究

  眞庭 謙昌

  科学研究費補助金／基盤研究(B), Apr. 2014 - Mar. 2017, Principal investigator

  Competitive research funding


• 乳癌および肺癌におけるTYRO3を標的とする治療法開発の妥当性の検討

  南 博信

  学術研究助成基金助成金／基盤研究(C), Apr. 2014 - Mar. 2017

  Competitive research funding


• A phase II study of induction cisplatin plus TS-1 with concurrent radiotherapy (66Gy) followed by surgical resection in patients with superior sulcus tumor

  TSUSHIMA Yukio, SUZUKI Kenji, TAKAMOCHI Kazuya, OH Shiaki, OKADA Morihito, IKEDA Norihiko, TANAKA Fumihiro, OKUMURA Sakae, NAKAMURA Haruhiko, SUZUKI Hiroyuki, NAKAMURA Hiroshige, IWATA Hisashi, TSUBOI Masahiro, SUGIO Kenji, MANIWA Yoshimasa, UEDA Kazuhiro, DOKI Yoshinori, MAEHARA Yoshihiko, UENO Tsuyoshi, TAKENOYAMA Mitsuhiro, URAMOTO Hidetaka, YOSHINO Ichiro, NAGASIMA Takuya, SHIONO Satoshi, MATSUURA Motoki, OKUMURA Norihito, HORIO Hirotoshi, INASAWA Keitaro, FUNAI Kazuhito, ITOU Hiroyuki

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Juntendo University, 01 Apr. 2012 - 31 Mar. 2015

  The standard treatment strategy for superior sulcus tumor without mediastinal lymph node involvement and distant metastasis is an induction concurrent chemoradiation followed by surgery. However, the surgical outcomes are far from satisfactory (local recurrence rate = 9~13%, 5 year-survival rate = 44~56%). Therefore, we planned a multicentre,single arm,confirmatory trial to evaluate the effectiveness and safety of induction cisplatin plus TS-1 with concurrent radiotherapy(66Gy) followed by surgical resection in patients with superior sulcus tumor (UMIN000014386). This induction therapy consists of the latest platinum doublet chemotherapy and the maximum dose of irradiation, which would to be the strongest treatment to date. This study started from June 2014 and is now going on to recruit 60 patients during 3 years.


• 定量的コンピュータ断層血流評価とオミックス情報による肺癌の標準治療効果予測

  大野 良治

  科学研究費補助金／基盤研究(C), Apr. 2012 - Mar. 2015

  Competitive research funding


• The role of Necl-5 in the invasive activity of lung adenocarcinoma

  MANIWA YOSHIMASA, HAYASHI Yoshitake

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Kobe University, Apr. 2011 - Mar. 2014, Principal investigator

  In this study,we used a bronchioloalveolar carcinoma (BAC) cell line and fibroblasts to assess the expression of Necl-5 in the development of cancer–stroma communication by using an easy-to-prepare double-layered collagen gel hemisphere (DL-CGH) systemthat enables visualization of cellmigration during invasion. The expression of Necl-5 was higher in BAC cells than in fibroblasts. This tendency didn't change even when the BAC cells were mixed with fibroblasts. To assess the role of Necl-5 in the invasive activity of the BAC cells, we knocked down its expression using RNA interference (RNAi). The invasion assay with DL-CGH revealed that inhibition of Necl-5 expression in the BAC cells was associated with suppressed invasiveness. Necl-5 expression in lung cancer cells is crucial for their invasiveness in the cancer–stromal interaction, suggesting that Necl-5 could be a favorable molecular target for the suppression of invasiveness in lung adenocarcinoma.

  Competitive research funding


• The role of cancer-host interaction in the invasion of lung adenocarcinoma

  MANIWA Yoshimasa, HAYASHI Yoshitake

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Kobe University, Apr. 2008 - Mar. 2011, Principal investigator

  A total of 63 surgically resected primary pulmonary adenocarcinoma tissues were investigated by immunohistochemistry for the expression of Necl-5. The overexpression of Necl-5 by cancer cells was significantly associated with lymph node metastasis, TNM staging and the bronchioloalveolar carcinoma ratio of tumors. Furthermore, the disease-free survival rate in patients with positive Necl-5 overexpression was significantly lower than that in patients with negative Necl-5 overexpression. These results indicate that Necl-5 plays a role in mediating tumor cell invasion and that the overexpression of Necl-5 in cancer cells has clinical significance for prognostic evaluation of patients with primary pulmonary adenocarcinoma.

  Competitive research funding


• Non-synonymous SNPs of DNA damage repair genes in lung cancer patients

  MANIWA Yoshimasa, OKITA Yutaka, HAYASHI Yoshitake

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Kobe University, Apr. 2006 - Mar. 2008, Principal investigator

  In this study, we identified gene alterations in lung cancer patients, not from the perspective of acquired mutations caused by various external insults or damaging agents, but from the perspective of hereditary predisposition. We evaluated all the non-synonymous SNPs in the DNA damage repair genes that are present in the available databases, which should allow us to detect those that are closely related with the development of lung adenocarcinoma. Finally, we will organize the data statistically and systematically to facilitate the prediction of a patient's cancer risk. As a results, we confirmed that nonsynonymous SNPs (XRCCI: Arg194Trp, TDG: Gly199Ser, RAD9: His239Arg, POLδ1: Arg119His) were present significantly more frequently in lung cancer patients than in a control group. Alignment analysis revealed that all of the region that contained the SNPs conserved among vertebrates, and the allele frequency is less than 1 % in a normal control population. These findings suggest that this SNP may cause an alteration in the biological activity of the expressed protein. These SNPs may allow to predict the susceptibility of lung cancer in a healthy person.

  Competitive research funding


• 肝炎ウイルス非感染肝細胞癌発生の分子機序の解明

  林 祥剛

  日本学術振興会, 科学研究費補助金／萌芽研究, 萌芽研究, 神戸大学, 2006 - 2008

  近年、脂肪肝から肝硬変および肝癌への進展が問題視されています。脂質代謝に関連のある血管内皮リパーゼ(Endothelial lipase; EL)をKnock outしたマウスに高脂肪食を与えると、単なる脂肪肝ではなくNASHが発生することを見出し、このマウスの病態を解明することによりヒトにおけるNASHの病態解明の一助になると考える。このマウスにおける脂肪性肝炎の発生機序としてELが欠如しているため脂肪細胞での脂肪分解が低下し脂肪細胞の肥大化と脂肪細胞から分泌されるアディポサイトカインの分泌異常が起こりインスリン抵抗性を惹起したと考えられた。それに伴い高インスリン血症が誘導され、肝臓での脂肪酸の流入増加と酸化ストレスの上昇から脂肪性肝炎を引き起こした可能性が考えられた。脂肪性肝炎の発症機序としてすでに2ヒットセオリーが提唱されている、これは1st Fitとして脂肪肝やそれに伴うインスリン抵抗性のある状態に2nd Fitとして酸化ストレスや脂質過酸化、炎症性サイトカインが加わり脂肪性肝炎を発症するとされるものである。このモデルにおいても普通食のKOマウスにおいては脂肪性肝炎は認めず高脂肪食負荷のKOマウスに脂肪性肝炎を認めたことから1st fit 2^ fit両者の存在で脂肪性肝炎を発症することが証明された。結論Endothelial lipase KO mouseにおけるNASH発生機序としてインスリン抵抗性、炎症性サイトカインの増加、アディポネクチンの低下が関与している可能性が示唆された。 (the 18th Confbrence of the Asian Pacific Association fbr the Study of the Liver,ソウル、韓国)

  Competitive research funding


• The differentiating regulation from bone marrow stem cells and hepatic stem cells to hepatocytes and bile-duct cells as a tool of treatment against hepatic failure

  HAYASHI Yoshitake, KU Yonson, SEO Yasushi, KANOMATA Naoki, MASIWA Yoshimasa, TSUJIMURA Tohru

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Kobe University, 2005 - 2007

  In fluminant hepatitis or Small Size for Graft cases, it is the most important that rapid recovery from liver failure is induced. Forkhead transcription factor FoxO mediates the function and differentiation of hepatocytes. And transfer from nuclear (active as a transcriptional nuclear protein) to cytoplasm (inactive) is controlled by PI3-kinase/Akt depending phosphorysation cascade. The new binding protein to FoxO1, P13, which is essential for adipocyte-differentiation and play an important role as a repressor of FoxO1, a transcriptional regulator and sensitizer of insulin, was found out. (J Clin Investigation 116(9): 2473-83, 2006; Diabetes in press; the 19^th Molecular Diabetology Symposium, Kobe). SgIGSF is an intercellular adhesion molecule of the nectin-like family. In developing mouse liver, SgIGSF expression was transiently upregulated at perinatal ages and was restricted to the lateral membrane of biliary epithelial cells (BECs). To investigate the role of SgIGSF in bile duct/ductule formation, An in vitro model, in which rat hepatocyte aggregates embedded in collagen gels containing insulin and epidermal growth factor extend epithelial sheets and processes in the first week and form ductules within a month, was used. The process and ductular cells were continuously positive for SgIGSF and cytokeratin 19, a BEC marker. When the aggregate culture was started in the presence of a function-blocking anti-SgIGSF antibody, the number of epithelial processes per aggregate was reduced by 80%. These data suggests that SgIGSF is a novel and functional BEC adhesion molecule that is expressed for a limited time during active bile duct/ductule formation. (Hepatology, 45:684-694, 2007)

  Competitive research funding


• Significance of hRad9 expression in non-small cell lung cancer cells

  MANIWA Yoshimasa, YOSHIMURA Masahiro, OKITA Yutaka, HAYASHI Yoshitake

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Kobe University, Apr. 2004 - Mar. 2006, Principal investigator

  hRad9 accumulation was observed in the nuclei of tumor cells in 33% of all nonsmall cell lung carcinoma (NSCLC) specimens examined, and elevated levels of phosphorylated hRad9 were found to be associated with the detection of phosphorylated Chk1. To the authors' knowledge, the current study was the first to describe the overexpression of hRad9 in surgically reseated tumor specimens and its phenotypic significance in tumor cells. Sequence analyses of the HRAD9 gene derived from 50 surgical specimens of lung adenocarcinoma were performed to investigate the status of this gene. Analysis of the coding regions indicated that there was no alteration in the HRAD9 sequence. Quantitative polymerase chain reaction of mRNA revealed that the gene was transcribed in all samples examined. However, these studies detected the presence of a nonsynonymous single nucleotide polymorphism (His239Arg) that occurred with a high frequency. This polymorphism appears to be associated with an increased risk of lung adenocarcinoma.

  Competitive research funding


• 癌転移のメカニズムとその予防―VEGFによる微小転移巣増大に関して

  真庭 謙昌

  日本学術振興会, 科学研究費助成事業, 奨励研究(B), 神戸大学医学部付属病院, 1998 - 1998, Principal investigator