Research activity information

• Jun. 2024 令和6年度神戸大学優秀若手研究者賞


• Jun. 2022 日本麻酔科学会第69回学術集会 若手奨励賞


• Oct. 2021 令和2年度神戸大学医学部優秀学術論文賞

• Right-to-left shunt due to iatrogenic atrial septal defect manifested by aorto-caval fistula: a case report

  Takuya Kimura, Takuya Okada, Norihiko Obata, Yasushi Motoyama, Masaharu Nagae

  Abstract Background An aorto-caval fistula is a rare but critical complication of abdominal aortic aneurysm (AAA) rupture, leading to high-output heart failure and increased venous pressure. The anesthetic management of such cases, particularly when complicated by an intraoperative right-to-left shunt, is seldom reported. Case presentation A 71-year-old man with a history of atrial fibrillation and catheter ablation presented with heart failure and abdominal pain, leading to cardiac arrest. Imaging revealed an AAA rupture into the inferior vena cava. During emergency surgery, severe venous bleeding was managed using intra-aortic balloon occlusion (IABO). Transesophageal echocardiography (TEE) identified a right-to-left shunt due to an iatrogenic atrial septal defect. Conclusion Early TEE recognition and timely IABO intervention were crucial in managing this complex case, underscoring the importance of these techniques in similar emergency scenarios.

  Corresponding, Springer Science and Business Media LLC, Aug. 2024, JA Clinical Reports, 10(1) (1)

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Anesthetic management of extracorporeal membrane oxygenation-supported aortic bypass surgery for atypical coarctation with severe left ventricular dysfunction: A case report

  Shusuke Okamoto, Takuya Okada, Norihiko Obata, Masahiko Iseki, Yu Yamane, Masaharu Nagae

  Corresponding, Elsevier BV, Aug. 2024, Heliyon, 10(15) (15), e35605 - e35605

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Anesthetic management of Stanford type B acute aortic dissection that occurred during transcatheter aortic valve implantation under monitored anesthesia care: A case report

  Shusuke Okamoto, Takuya Okada, Norihiko Obata, Yu Yamane, Koichiro Masada, Masahiko Iseki, Masaharu Nagae

  Corresponding, Elsevier BV, Nov. 2023, Heliyon, 9(11) (11), e21278 - e21278

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Effect of Intrathecal Urokinase Infusion on Cerebral Vasospasm After Aneurysmal Subarachnoid Hemorrhage

  Masayuki Yokota, Takuya Okada, Masahiro Asaeda, Tomoko Iida, Shuichi Tanada, Shoichiro Tuji, Taishi Nigami

  Elsevier BV, Oct. 2023, World Neurosurgery

  [Refereed]

  Scientific journal


• Pain induces stable, active microcircuits in the somatosensory cortex that provide a therapeutic target.

  Takuya Okada, Daisuke Kato, Yuki Nomura, Norihiko Obata, Xiangyu Quan, Akihito Morinaga, Hajime Yano, Zhongtian Guo, Yuki Aoyama, Yoshihisa Tachibana, Andrew J Moorhouse, Osamu Matoba, Tetsuya Takiguchi, Satoshi Mizobuchi, Hiroaki Wake

  Sustained neuropathic pain from injury or inflammation remains a major burden for society. Rodent pain models have informed some cellular mechanisms increasing neuronal excitability within the spinal cord and primary somatosensory cortex (S1), but how activity patterns within these circuits change during pain remains unclear. We have applied multiphoton in vivo imaging and holographic stimulation to examine single S1 neuron activity patterns and connectivity during sustained pain. Following pain induction, there is an increase in synchronized neuronal activity and connectivity within S1, indicating the formation of pain circuits. Artificially increasing neuronal activity and synchrony using DREADDs reduced pain thresholds. The expression of N-type voltage-dependent Ca2+ channel subunits in S1 was increased after pain induction, and locally blocking these channels reduced both the synchrony and allodynia associated with inflammatory pain. Targeting these S1 pain circuits, via inhibiting N-type Ca2+ channels or other approaches, may provide ways to reduce inflammatory pain.

  Lead, Mar. 2021, Science advances, 7(12) (12), English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Anesthetic Management of Transcatheter Aortic Valve Replacement under Extracorporeal Membrane Oxygenation in a Patient with Acute Decompensated Heart Failure: A Case Report.

  Takuya Okada, Takuya Yoshida, Shohei Makino, Norihiko Obata, Satoshi Mizobuchi

  We managed general anesthesia for transcatheter aortic valve replacement (TAVR) under elective extracorporeal membrane oxygenation (ECMO) in a patient with aortic valve stenosis (AS) complicated with acute decompensated heart failure. The patient was an 87-year-old woman with acute heart failure due to severe AS who had been hospitalized. However, her low cardiac output did not improve, and weaned her off catecholamines was difficult, so semi-urgent TAVR was performed. Due to her acute decompensated heart failure complicated by low-left ventricular function, we decided electively to use ECMO for transfemoral TAVR to prevent hemodynamic collapse during induction of anesthesia and surgery, enabling the safe perioperative management of this patient under general anesthesia.

  Lead, Nov. 2019, The Kobe journal of medical sciences, 65(3) (3), E90-E94, English, Domestic magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• A case of ventilatory impairment during per-oral endoscopic myotomy under general anesthesia.

  Takuya Okada, Shinichiro Izuta, Satoshi Mizobuchi

  ᅟ: We report a case of unexpected ventilatory impairment that occurred during per-oral endoscopic myotomy (POEM) under general anesthesia. A 73-year-old woman underwent POEM for Jackhammer esophagus. The patient developed hypercarbia, pneumoperitoneum, and severe subcutaneous emphysema during the operation. Although she was treated with abdominal paracentesis, it became difficult to ventilate her lungs a few minutes later. We recommended the surgeons to interrupt the procedure and proposed repeating the abdominal paracentesis. Simultaneously, we switched to manual ventilation and waited for the subcutaneous emphysema to subside. Thereafter, her respiratory status gradually improved and the surgeons were able to continue the operation. We considered that the main reason for our patient's severe ventilatory impairment was that the length of surgical dissection was longer than usual.

  Lead, Feb. 2018, JA clinical reports, 4(1) (1), 23 - 23, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• A case of delayed respiratory depression caused by accidental subcutaneous opioid infusion.

  Takuya Okada, Moritoki Egi, Hitoaki Sato, Yuki Nomura, Masako Okada, Shinichiro Izuta, Satoshi Mizobuchi

  We report a case of delayed respiratory depression due to accidental subcutaneous opioid infusion. A healthy 33-year-old woman underwent orthopedic surgery under general anesthesia. Before the end of the operation, it was noticed that a part of the opioid infusion had been administered subcutaneously. About 15 min after tracheal extubation, the patient developed respiratory depression and loss of consciousness. The patient recovered with the use of jaw lift together with bag-valve-mask ventilation. We believe that accidental subcutaneous opioid accumulation may have caused the respiratory depression.

  Lead, Jun. 2016, Journal of anesthesia, 30(3) (3), 489 - 92, English, Domestic magazine

  [Refereed]

  Scientific journal

• 麻酔科領域に関与する遺伝子多型

  野村有紀, 小幡典彦, 岡田卓也, 久保田健太, 藤本大地, 法華真衣, 本山泰士, 白川尚隆, 畑澤佐知, 大田有理, 喜多加枝, 小阪円, 辰巳仁美, 清水雅明, 山脇緑, 若林潤二, 淺越佑太郎, 西村太一, 柘植江里香, 髙岡悠子, 瀧口侑子, 上野喬平, 篠崎裕美, 巻野将平, 長江正晴, 末原知美, 吉田卓矢, 北原淳一郎, 中川明美, 大井まゆ, 上嶋江利, 岡田雅子, 眞田かなえ, 三住拓誉, 佐藤仁昭, 江木盛時, 出田眞一郎, 高雄由美子, 溝渕知司

  2015, 臨床麻酔, 39(7) (7)

  Introduction scientific journal

• 麻酔管理の疑問に答える生理学

  岡田卓也, 溝渕知司

  Joint work, 麻酔科医に必要な腎臓生理 2.手術侵襲は腎機能にどのような影響を及ぼしているのか？, 文光堂, May 2023, Japanese, ISBN: 9784830628559


• 麻酔・2022・71巻増刊号

  岡田卓也, 野村有紀, 小幡典彦, 加藤大輔, 和氣弘明, 溝渕知司

  Joint work, 大脳皮質体性感覚野における疼痛で誘発される局所神経回路の活動制御は急性疼痛に対する新たな治療標的になりうる, 克誠堂, Nov. 2022


• 麻酔科トラブルシューティング A to Z 第2版

  岡田卓也, 溝渕知司

  Joint work, 第Ⅱ章 僧帽弁狭窄症がある, 文光堂, 2022

• 多剤服用となっていた化学療法誘発性末梢神経障害性疼痛患者に対し入院による薬剤調整で症状を改善し得た1例

  西原侑紀, 岡田卓也, 上野喬平, 野村有紀, 佐藤仁昭, 溝渕知司

  日本ペインクリニック学会 第5回 関西支部学術集会, Oct. 2024

  Oral presentation


• Fontan術後患者の腹腔鏡下卵巣摘出術に対しレミマゾラムを用いて管理を行った一例

  宮﨑里菜, 法華真衣, 箱田圭吾, 岡田卓也, 溝渕知司

  日本心臓血管麻酔学会第29回学術大会, Sep. 2024

  Oral presentation


• 神経障害性疼痛における脳内ミクログリアの寄与と性差に関する検討

  中村友季子, 岡田卓也, 野村有紀, 溝渕知司

  日本麻酔科学会第71回学術集会, Jun. 2024


• 生体カルシウムイメージング法による全身麻酔薬が大脳皮質神経細胞活動に及ぼす影響の検討

  杉野太亮, 岡田卓也, 野村有紀, 溝渕知司

  日本麻酔科学会第71回学術集会, Jun. 2024

  Oral presentation


• SGLT2内服患者が術後に多尿をきたし循環管理に難渋した１例

  服部望, 岡田卓也, 小村隆一郎, 八代和也, 木村拓也, 安本高規, 山根悠

  日本臨床麻酔学会第43回大会, Dec. 2023


• ハイブリットERでの緊急開腹手術の麻酔経験

  小村隆一郎, 安本高規, 岡田卓也, 山根悠

  日本臨床麻酔学会第43回大会, Dec. 2023


• 成人単純型大動脈縮窄症を合併した右内頸脳動脈瘤患者に対する脳動脈コイル塞栓術の麻酔経験

  八代和也, 山根悠, 岡田卓也, 小村隆一郎, 服部望, 木村拓也, 安本高規

  日本臨床麻酔学会第43回大会, Dec. 2023


• 腹部大動脈瘤が下大静脈に穿破したが、大動脈閉塞バルーンにより救命できた１例

  木村拓也, 岡田卓也, 山根悠

  日本臨床麻酔学会第43回大会, Dec. 2023


• 重症肺気腫を合併した胸腹部大動脈瘤患者に対して術式と麻酔法を工夫した１例

  植島康博, 山根悠, 岡田卓也, 長江正晴

  日本麻酔科学会 第69回関西支部学術集会, Sep. 2023


• 大量出血が予想された胸部刺創患者の１例

  小村隆一郎, 岡田卓也, 植島康博, 山根悠, 長江正晴

  日本麻酔科学会 第69回関西支部学術集会, Sep. 2023


• 胸腹部大動脈瘤に対する人工血管置換術中にアナフィラキシーショックを生じた１例

  服部望, 岡本修佑, 岡田卓也, 山根悠, 本山泰士, 長江正晴

  日本麻酔科学会 第69回関西支部学術集会, Sep. 2023


• 胸部大動脈瘤に対する全弓部大動脈人工血管置換術後に生じた対麻痺に初期治療が奏功した１例

  井関将彦, 岡田卓也, 岡本修佑, 木村拓也, 山根悠

  日本心臓血管麻酔学会第28回学術集会, Sep. 2023


• 局所麻酔下のTF-TAVI中に全身麻酔へ切り替えが必要となった３症例の検討

  正田康一郎, 山根悠, 井関将彦, 岡本修佑, 岡田卓也, 長江正晴

  日本麻酔科学会第70回学術集会, Jun. 2023


• 痛みの”見える化”

  岡田 卓也

  日本麻酔科学会 第68回関西支部学術集会, Sep. 2022

  [Invited]

  Invited oral presentation


• 植込型左室補助人工心臓装着術直後に判明した肺動脈カテーテル縫い込みに対して再開胸手術を行った一例

  原田 みどり, 宮崎 純志, 中山 莉子, 岡田 卓也, 法華 真衣, 溝渕 知司

  日本心臓血管麻酔学会第27回学術大会, Sep. 2022


• 慢性痛患者におけるレンボレキサントによる睡眠改善と痛みの関連に関する検討

  上野喬平, 佐藤仁昭, 森梓, 岡田卓也, 野村有紀, 溝渕知司

  日本ペインクリニック学会第56回大会, Jul. 2022

  Oral presentation


• 大脳皮質体性感覚野における疼痛で誘発された局所神経回路の活動制御は急性疼痛に対する新たな治療標的になりうる

  岡田卓也, 野村有紀, 小幡典彦, 加藤大輔, 和氣弘明, 溝渕知司

  日本麻酔科学会第69回学術集会, Jun. 2022

  Nominated symposium


• 抗うつ薬としてのケタミンは腹側海馬と一次体性感覚野において解離的作用をもたらす

  味岡 雄大, 岡田 卓也, 春若 航一路, 橘 吉寿, 和氣 弘明

  第43回日本神経科学大会, Jul. 2020

  Poster presentation


• 疼痛制御における大脳皮質第一次体性感覚野の神経細胞活動変化とN型カルシウムイオンチャネルの役割

  岡田卓也, 野村有紀, 小幡典彦, 橘吉寿, 和氣弘明, 溝渕知司

  日本麻酔科学会第67回学術集会, Jul. 2020

  Oral presentation


• Effects of N-type calcium ion channel function on the neuronal activities of the primary somatosensory cortex in inflammatory pain model

  Takuya Okada, Yuki Nomura, Norihiko Obata, Satoshi Mizobuchi

  Euroanaesthesia 2020, Jun. 2020

  Poster presentation


• In vivo tracing of single neuron activity of primary somatosensory cortex in mice pain models

  Takuya Okada, Yuki Nomura, Yoshihisa Tachibana, Norihiko Obata, Hiroaki Wake, Satoshi Mizobuchi

  ANESTHESIOLOGY(R) 2019 annual meeting, Oct. 2019

  Poster presentation


• 降圧薬投薬により痛みが消失したRaeder症候群の一例

  酒巻 綾音, 阿瀬井 宏佑, 岡田 卓也, 本山 泰士, 上野 喬平, 佐藤 仁昭, 溝渕 知司

  日本ペインクリニック学会第53回大会, Jul. 2019

  Poster presentation


• 生体カルシウムイメージングによる大脳皮質第一次体性感覚野における同一神経細胞活動の変化が疼痛閾値に与える影響の検討

  岡田 卓也, 野村 有紀, 小幡 典彦, 橘 吉寿, 和氣 弘明, 溝渕 知司

  日本麻酔科学会第66回学術集会, May 2019

  Oral presentation


• In vivo Ca2+ imaging of somatosensory cortex in postoperative and inflammatory pain models of mice

  Takuya Okada, Yoshihisa Tachibana, Yuki Nomura, Norihiko Obata, Satoshi Mizobuchi, Hiroaki Wake

  The 9th Federation of Asian and Oceanian Physiological Societies Congress: FAOPS 2019, Mar. 2019

  Poster presentation


• 大脳皮質感覚野の生体イメージングによる疼痛発症機構解明へのアプローチ

  岡田 卓也, 橘 吉寿, 野村 有紀, 小幡 典彦, 溝渕 知司, 和氣 弘明

  第111回近畿生理学談話会, Nov. 2018

  Oral presentation


• In vivo tracing of single neuron activity with Ca2+ imaging of primary somatosensory cortex in mouse models of postoperative pain and inflammatory pain

  Takuya Okada, Yoshihisa Tachibana, Yuki Nomura, Norihiko Obata, Satoshi Mizobuchi, Hiroaki Wake

  Neuroscience 2018, Nov. 2018

  Poster presentation


• In vivo tracing of single neuron activity with Ca2+ imaging of primary somatosensory cortex in mouse models of postoperative pain and inflammatory pain

  Takuya Okada, Yosihisa Tachibana, Yuki Nomura, Norihiko Obata, Satoshi Mizobuchi, Hiroaki Wake

  Cold Spring Harbor Asia Confference, Sep. 2018

  Poster presentation


• 術後痛モデルマウスにおける第一次体性感覚野 in vivo カルシウムイメージング

  岡田 卓也, 橘 吉寿, 野村 有紀, 小幡 典彦, 溝渕 知司, 和氣 弘明

  第41回日本神経科学大会, Jul. 2018

  Poster presentation


• 非代償性急性心不全合併大動脈弁狭窄症に対する経皮的心肺補助併用下経カテーテル大動脈弁置換術の麻酔管理

  岡田 卓也, 吉田 卓矢, 巻野 将平, 小幡 典彦, 溝渕 知司

  日本心臓血管麻酔学会第22回学術大会, Sep. 2017

  Poster presentation


• 気管狭窄をきたすほど高度拡張したアカラシアに対する経口内視鏡的筋層切開術(POEM)の麻酔経験

  吉田 卓矢, 出田 眞一郎, 大井 まゆ, 岡田 卓也, 溝渕 知司

  第62回日本麻酔科学会関西支部学術集会, Sep. 2016

  Poster presentation


• 大動脈人工血管置換術における分離肺換気下・部分体外循環施行前後の肺酸素化能の変化

  岡田卓也, 斎藤範建, 吉田卓矢, 法華真衣, 江木盛時, 溝渕知司

  日本麻酔科学会第63回学術集会, May 2016

  Poster presentation


• 術中のレミフェンタニルの血管外漏出により術後呼吸抑制を来したと考えられた一例

  岡田 卓也, 江木 盛時, 出田 眞一郎, 溝渕 知司

  日本臨床麻酔学会 第35回大会, Oct. 2015

  Poster presentation


• 神戸大学附属病院集中治療部における誤嚥性肺炎に対する薬物治療法

  岡田卓也, 三住拓誉, 江木盛時, 溝渕知司

  第59回日本集中治療学会近畿地方大会, Jul. 2014

  Oral presentation

• ドパミン受容体に着目した慢性疼痛受容に性差が生じるメカニズムの解明

  中村 友季子, 岡田 卓也

  日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, Apr. 2025 - Mar. 2028


• 生体イメージングによるプロポフォールおよびデクスメデトミジンの神経保護機構の解明

  岡田 卓也

  日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, Apr. 2025 - Mar. 2028


• 生体イメージングを用いた術後認知機能障害の機序解明

  杉野 太亮, 岡田 卓也

  日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, Apr. 2023 - Mar. 2026


• Mechanism of general anesthetics by in vivo imaging

  岡田 卓也

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Kobe University, Apr. 2022 - Mar. 2025


• Pathophysiology of the neural circuit basis of the thalamus-higher brain regions involved in the chronic of pain

  OKADA TAKUYA

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists, Grant-in-Aid for Early-Career Scientists, Kobe University, Apr. 2020 - Mar. 2022

  To elucidate the neural circuit of chronic pain, we first used chemogenetics to change the activity of a pathway in the posterior thalamic nucleus to cortical somatosensory cortex (S1), which is thought to be a transmission pain pathway, and found that it affects pain threshold. In addition, using two-photon holographic microscopy, which can selectively stimulate each neuron, we evaluated the functional connections between each neuron and found that the number of responding neurons in the surrounding area increased during the acute phase of pain compared to baseline, and the number of responding neurons decreased as the pain threshold improved. This study demonstrates the importance of the posterior thalamic nucleus to S1 pathway in the formation of pain and the enhancement of functional connections between S1 neurons during the acute phase of pain.


• In vivo tracing of single neuron activity of primary somatosensory cortex in mice pain models

  OKADA TAKUYA

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists, Grant-in-Aid for Early-Career Scientists, Kobe University, Apr. 2018 - Mar. 2020

  In this research, to visualize neuronal activity, the adeno associated virus encoding the synapsin promoter driven calcium indicator protein GCaMP6f was expressed in layer Ⅱ/Ⅲ excitatory neurons of primary somatosensory cortex（S1）, we investigated the activity pattern of S1 neurons by using in vivo two-photon calcium imaging. We analyzed time dependent changes of neuronal activity and synchronization of neuronal activity during acute phase of pain in mice models of pain. As a results, the paw withdrawal threshold was significantly decreased in the affected hind paw of both models in acute pain phase. Therefore, the integral value of Ca2+ traces and the correlational activity among GCaMP6f-expressing excitatory neurons increased in both models in acute pain phase. Furthermore, by using chemogenetic method, we succeeded to enhance or inhibit neuronal activity of S1 neurons in vivo. We found the threshold of pain significantly changed by artificial control of S1 neuronal activity.