研究者紹介システム

祖父江 慶太郎
ソフエ ケイタロウ
医学部附属病院 放射線診断・IVR科
講師
医学
Last Updated :2022/08/15

研究者情報

所属

  • 【主配置】

    医学部附属病院 放射線診断・IVR科
  • 【配置】

    大学院医学研究科 医科学専攻, 医学部附属病院 IVRセンター

学位

  • 博士(医学), 神戸大学

授業科目

ジャンル

  • 医療・健康 / がん治療
  • 医療・健康 / 臨床医学

コメントテーマ

  • 肝癌
  • 分子標的療法
  • 画像診断

研究活動

研究キーワード

  • 腹部画像診断
  • IVR

研究分野

  • ライフサイエンス / 放射線科学

委員歴

  • 2019年10月 - 現在, 日本肝臓学会, 肝癌診療ガイドライン 専門委員
  • 2012年04月 - 2018年03月, 日本IVR学会, ガイドライン委員
  • 2010年04月 - 現在, 日本医学放射線学会, ガイドライン委員

受賞

  • 2020年01月 神戸大学, 令和元年度神戸大学優秀若手研究者賞

    祖父江 慶太郎

  • 2019年12月 日本肝臓学会, 第43回日本肝臓学会西部会 男女共同参画委員会関連企画 優秀賞

    祖父江慶太郎

    日本国

    国内学会・会議・シンポジウム等の賞

  • 2018年12月 Radiological Society of North America, Certificate of Merit

    祖父江 慶太郎

  • 2017年07月 Society of Advanced Medical Imaging, 第2回Advanced Medical Imaging研究会 大会長賞 最優秀賞, 学会発表

    祖父江慶太郎

    国内学会・会議・シンポジウム等の賞

  • 2016年09月 日本腹部放射線学会, 日本腹部放射線学会バイエル奨励賞, 個人

    祖父江慶太郎

    国内学会・会議・シンポジウム等の賞

  • 2015年04月 日本医学放射線学会, 板井研究奨励賞, 個人

    祖父江慶太郎

    国内学会・会議・シンポジウム等の賞

  • 2014年04月 日本放射線医会, 第26回コニカミノルタ日米放射線医留学生助成

    祖父江 慶太郎

  • 2013年12月 Radiological Society of North America, Certificate of Merit

    祖父江 慶太郎

  • 2013年09月 Bayer国際交流促進制度 IVR関連国際学会フェローシップ

    祖父江 慶太郎

論文

  • Koji Sasaki, Takuya Okada, Masato Yamaguchi, Mostafa Ahmed, Tomoyuki Gentsu, Eisuke Ueshima, Keitaro Sofue, Kenji Tanimura, Hideto Yamada, Koji Sugimoto, Takamichi Murakami

    PURPOSE: To evaluate the efficacy of superselective transcatheter arterial embolization (TAE) for intractable postpartum hemorrhage (PPH) due to genital tract trauma (GTT) after vaginal delivery. METHODS: We evaluated 27 patients who underwent TAE for intractable PPH due to GTT after vaginal delivery at our institution between January 2008 and December 2020. Patients were divided into two groups according to TAE procedure; TAE performed as close as possible to the bleeding point, at least more peripherally than the second branch of the anterior division of the internal iliac artery, was defined as superselective TAE (S-TAE). TAE performed from the proximal segment of the internal iliac artery was defined as proximal TAE (P-TAE). Patient characteristics, pre-procedural contrast-enhanced computed tomography (CE-CT), procedure details, technical/clinical success, and complications were evaluated separately for the S-TAE and P-TAE groups. RESULTS: The combined technical/clinical success rate was 92%. No major procedure-related complications were seen (mean follow-up: 6.12 ± 3.93 days). The combined technical/clinical success rate of S-TAE was 100% and of P-TAE was 67% (p = 0.04). S-TAE was performed more frequently in patients with pre-procedural CE-CT (p = 0.01) and use of permanent embolic materials (p = 0.003). CONCLUSION: S-TAE is safe and effective for intractable PPH due to GTT. Pre-procedural CE-CT may be useful for detecting the culprit artery and be helpful in performing S-TAE.

    2021年12月, Emergency radiology, 28 (6), 1127 - 1133, 英語, 国際誌

    研究論文(学術雑誌)

  • Satoshi Omiya, Shohei Komatsu, Masahiro Kido, Kaori Kuramitsu, Hidetoshi Gon, Kenji Fukushima, Takeshi Urade, Shinichi So, Keitaro Sofue, Yoshihiko Yano, Yoshitada Sakai, Hiroaki Yanagimoto, Hirochika Toyama, Tetsuo Ajiki, Takumi Fukumoto

    BACKGROUND/AIM: Sarcopenia has been reported to be a significant prognostic factor in patients with hepatocellular carcinoma in recent years. This study aimed to clarify the prognostic significance of sarcopenia in advanced hepatocellular carcinoma treated with reductive hepatectomy. PATIENTS AND METHODS: We retrospectively analyzed 93 patients who underwent reductive hepatectomy for advanced hepatocellular carcinoma. RESULTS: Median survival time of the sarcopenia group (16.4 months) was significantly shorter than that of the non-sarcopenia group (20.4 months). The overall survival rates at 1, 3, and 5 years of the sarcopenia group were significantly lower than those of the non-sarcopenia group (57.9%, 8.6%, and 2.9% vs. 67.3%, 29.2%, and 15.7%, respectively; p=0.035). On multivariate analysis, sarcopenia was a significant risk factor of overall survival (hazard ratio=1.60, 95% confidence interval=1.00-2.56, p=0.049). CONCLUSION: Sarcopenia was a significant prognostic factor of survival after reductive hepatectomy in advanced hepatocellular carcinoma.

    2021年11月, Anticancer research, 41 (11), 5775 - 5783, 英語, 国際誌

    研究論文(学術雑誌)

  • Keitaro Sofue, Eisuke Ueshima, Atsuhiro Masuda, Sachiyo Shirakawa, Yoh Zen, Yoshiko Ueno, Yushi Tsujita, Takeru Yamaguchi, Shinji Yabe, Takeshi Tanaka, Noriko Inomata, Hirochika Toyama, Takumi Fukumoto, Yuzo Kodama, Takamichi Murakami

    OBJECTIVE: To investigate the diagnostic performance of the extracellular volume (ECV) fraction in multiphasic contrast-enhanced computed tomography (CE-CT) for estimating histologic pancreatic fibrosis and predicting postoperative pancreatic fistula (POPF). METHODS: Eighty-five patients (49 men; mean age, 69 years) who underwent multiphasic CE-CT followed by pancreaticoduodenectomy with pancreaticojejunal anastomosis between January 2012 and December 2018 were retrospectively included. The ECV fraction was calculated from absolute enhancements of the pancreas and aorta between the precontrast and equilibrium-phase images, followed by comparisons among histologic pancreatic fibrosis grades (F0‒F3). The diagnostic performance of the ECV fraction in advanced fibrosis (F2‒F3) was evaluated using receiver operating characteristic curve analysis. Multivariate logistic regression analysis was used to evaluate the associations of the risk of POPF development with patient characteristics, histologic findings, and CT imaging parameters. RESULTS: The mean ECV fraction of the pancreas was 34.4% ± 9.5, with an excellent intrareader agreement of 0.811 and a moderate positive correlation with pancreatic fibrosis (r = 0.476; p < 0.001). The mean ECV fraction in advanced fibrosis was significantly higher than that in no/mild fibrosis (44.4% ± 10.8 vs. 31.7% ± 6.7; p < 0.001), and the area under the receiver operating characteristic curve for the diagnosis of advanced fibrosis was 0.837. Twenty-two patients (25.9%) developed clinically relevant POPF. Multivariate logistic regression analysis demonstrated that the ECV fraction was a significant predictor of POPF. CONCLUSIONS: The ECV fraction can offer quantitative information for assessing pancreatic fibrosis and POPF after pancreaticojejunal anastomosis. KEY POINTS: • There was a moderate positive correlation of the extracellular volume (ECV) fraction of the pancreas in contrast-enhanced CT with the histologic grade of pancreatic fibrosis (r = 0.476; p < 0.001). • The ECV fraction was higher in advanced fibrosis (F2‒F3) than in no/mild fibrosis (F0‒F1) (p < 0.001), with an AUC of 0.837 for detecting advanced fibrosis. • The ECV fraction was an independent risk factor for predicting subclinical (odds ratio, 0.81) and clinical (odds ratio, 0.80) postoperative pancreatic fistula.

    2021年10月12日, European radiology, 32 (3), 1770 - 1780, 英語, 国際誌

    研究論文(学術雑誌)

  • Koji Sasaki, Takuya Okada, Masato Yamaguchi, Masashi Tajiri, Mostafa Ahmed, Tomoyuki Gentsu, Eisuke Ueshima, Keitaro Sofue, Koji Sugimoto, Takamichi Murakami

    PURPOSE: The purpose is to investigate the major and minor complications of the pancreas after transcatheter arterial embolization (TAE) using n-butyl-2-cyanoacrylate (NBCA) for bleeding from pancreatic arteries. MATERIALS AND METHODS: Thirty-three patients who underwent TAE using NBCA for acute bleeding from pancreatic arteries and their parent arteries followed by contrast-enhanced computed tomography (CE-CT) were evaluated retrospectively. Complications and risk factors were assessed using Mann-Whitney U test or Fisher's exact test for the univariate analysis. Patients' characteristic, embolized artery, procedure details, and clinical outcomes were examined as possible risk factors. RESULTS: TAE was performed successfully in all patients. Minor pancreatic complications occurred in 10 patients (30%), including acute mild pancreatitis (n = 4) and focal lack of pancreatic parenchymal enhancement on CE-CT without pancreatitis (n = 6). No cases of major pancreatic complications, such as moderate/severe pancreatitis, were reported. Embolized artery was the only significant risk factor. The rate of complications per embolized artery were 15% (three out of 20 patients) in the arteries of the pancreatic head and 54% (seven out of 13 patients) in the arteries of pancreatic body and tail (p = 0.025). CONCLUSION: TAE using NBCA for acute bleeding from pancreatic arteries is efficacious and safe. Mild pancreatic complications were observed more frequently in case of embolization of the pancreatic body and tail region than the pancreatic head.

    2021年10月06日, Japanese journal of radiology, 40 (3), 308 - 317, 英語, 国内誌

    研究論文(学術雑誌)

  • Yoshiko Ueno, Tsutomu Tamada, Keitaro Sofue, Takamichi Murakami

    For assessing a cancer treatment, and for detecting and characterizing cancer, Diffusion-weighted imaging (DWI) is commonly used. The key in DWI's use extracranially has been due to the emergence of of high-gradient amplitude and multichannel coils, parallelimaging, and echo-planar imaging. The benefit has been fewer motion artefacts and high-quality prostate images.Recently, new techniques have been developed to improve the signal-to-noise ratio of DWI with fewer artefacts, allowing an increase in spatial resolution. For apparent diffusion coefficient quantification, non-Gaussian diffusion models have been proposed as additional tools for prostate cancer detection and evaluation of its aggressiveness. More recently, radiomics and machine learning for prostate magnetic resonance imaging have emerged as novel techniques for the non-invasive characterisation of prostate cancer. This review presents recent developments in prostate DWI and discusses its potential use in clinical practice.

    2021年09月19日, The British journal of radiology, 95 (1131), 20210653 - 20210653, 英語, 国際誌

    研究論文(学術雑誌)

  • Takamichi Murakami, Keitaro Sofue, Masatoshi Hori

    Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA; Gadoxetic acid; Gadoxetate disodium) is a hepatocyte-specific MR contrast agent. It acts as an extracellular contrast agent in the early phase after intravenous injection, and then is taken up by hepatocytes later. Using this contrast agent, we can evaluate the hemodynamics of the liver and liver tumors, and can therefore improve the detection and characterization of hepatocellular carcinoma (HCC). Gd-EOB-DTPA helps in the more accurate detection of hypervascular HCC than by other agents. In addition, Gd-EOB-DTPA can detect hypovascular HCC, which is an early stage of the multi-stage carcinogenesis, with a low signal in the hepatobiliary phase. In addition to tumor detection and characterization, Gd-EOB-DTPA contrast-enhanced MR imaging can be applied for liver function evaluation and prognoses evaluation. Thus, Gd-EOB-DTPA plays an important role in the diagnosis of HCC. However, we have to employ optimal imaging techniques to improve the diagnostic ability. In this review, we aimed to discuss the characteristics of the contrast media, optimal imaging techniques, diagnosis, and applications.

    2021年08月21日, Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine, 21 (1), 168 - 181, 英語, 国内誌

    研究論文(学術雑誌)

  • Yasuyo Urase, Yoshiko Ueno, Tsutomu Tamada, Keitaro Sofue, Satoru Takahashi, Nobuyuki Hinata, Kenichi Harada, Masato Fujisawa, Takamichi Murakami

    OBJECTIVE: To evaluate the interreader agreement and diagnostic performance of the Prostate Imaging Reporting and Data System (PI-RADS) v. 2.1, in comparison with v. 2. METHODS: Institutional review board approval was obtained for this retrospective study. 77 consecutive patients who underwent a prostate multiparametric magnetic resonance imaging at 3.0 T before radical prostatectomy were included. Four radiologists (two experienced uroradiologists and two inexperienced radiologists) independently scored eight regions [six peripheral zones (PZ) and two transition zones (TZ)] using v. 2.1 and v. 2. Interreader agreement was assessed using κ statistics. To evaluate diagnostic performance for clinically significant prostate cancer (csPC), area under the curve (AUC) was estimated. RESULTS: 228 regions were pathologically diagnosed as positive for csPC. With a cut-off ≥3, the agreement among all readers was better with v. 2.1 than v. 2 in TZ, PZ, or both zones combined (κ-value: TZ, 0.509 vs 0.414; PZ, 0.686 vs 0.568; both zones combined, 0.644 vs 0.531). With a cut-off ≥4, the agreement among all readers was also better with v. 2.1 than v. 2 in the PZ or both zones combined (κ-value: PZ, 0.761 vs 0.701; both zones combined, 0.756 vs 0.709). For all readers, AUC with v. 2.1 was higher than with v. 2 (TZ, 0.826-0.907 vs 0.788-0.856; PZ, 0.857-0.919 vs 0.853-0.902). CONCLUSION: Our study suggests that the PI-RADS v. 2.1 could improve the interreader agreement and might contribute to improved diagnostic performance compared with v. 2. ADVANCES IN KNOWLEDGE: PI-RADS v. 2.1 has a potential to improve interreader variability and diagnostic performance among radiologists with different levels of expertise.

    2021年07月08日, The British journal of radiology, 20201434 - 20201434, 英語, 国際誌

    研究論文(学術雑誌)

  • Mostafa Hamada, Eisuke Ueshima, Takeaki Ishihara, Yutaka Koide, Takuya Okada, Hiroki Horinouchi, Jun Ishida, Hiroshi Mayahara, Koji Sasaki, Tomoyuki Gentsu, Keitaro Sofue, Masato Yamaguchi, Ryohei Sasaki, Koji Sugimoto, Takamichi Murakami

    Background: Technological developments have led to an increased usage of external-body radiotherapy (RT) for the treatment of hepatocellular carcinoma (HCC). Transcatheter arterial chemoembolization (TACE) may be required later in patients treated with RT because of the high recurrence rate and multinodular presentation of HCC. However, despite the risk of liver function impairment, the cumulative liver damage correlated with TACE following a hepatic RT has not been adequately assessed. Purpose: To evaluate the feasibility of TACE following RT for HCC. Materials and methods: Sixty-seven patients with HCC who underwent TACE after RT were retrospectively evaluated between 2012 and 2018. We assessed increases in Child-Turcotte-Pugh (CTP) by ≥2 points at 1 month, the incidence of major complications, survival duration, and short-term mortality within 6 months after TACE. Furthermore, we evaluated the predictive factors for liver function impairment and short-term mortality. Results: Eight patients experienced a CTP increase ≥2 points at 1 month. There were no cases of liver abscesses or bilomas. Nine patients died within 6 months following TACE. The mean liver dose (MLD) was a significant predictor of liver function impairment at 1 month (p = 0.042). Low liver functional reserve, distant metastasis (p = 0.037), MLD (p = 0.046), TACE type (p = 0.025), and TACE within 3 months following RT (p = 0.007) were significant predictors of short-term mortality. Conclusions: Despite the feasibility of TACE following RT, clinicians should pay attention to impaired pretreatment liver function, following high dose RT, and the short duration between RT and TACE.

    2021年07月, Acta radiologica open, 10 (7), 20584601211034965 - 20584601211034965, 英語, 国際誌

    研究論文(学術雑誌)

  • Yasuyuki Kojita, Hidetoshi Matsuo, Tomonori Kanda, Mizuho Nishio, Keitaro Sofue, Munenobu Nogami, Atsushi K Kono, Masatoshi Hori, Takamichi Murakami

    OBJECTIVES: To evaluate a deep learning model for predicting gestational age from fetal brain MRI acquired after the first trimester in comparison to biparietal diameter (BPD). MATERIALS AND METHODS: Our Institutional Review Board approved this retrospective study, and a total of 184 T2-weighted MRI acquisitions from 184 fetuses (mean gestational age: 29.4 weeks) who underwent MRI between January 2014 and June 2019 were included. The reference standard gestational age was based on the last menstruation and ultrasonography measurements in the first trimester. The deep learning model was trained with T2-weighted images from 126 training cases and 29 validation cases. The remaining 29 cases were used as test data, with fetal age estimated by both the model and BPD measurement. The relationship between the estimated gestational age and the reference standard was evaluated with Lin's concordance correlation coefficient (ρc) and a Bland-Altman plot. The ρc was assessed with McBride's definition. RESULTS: The ρc of the model prediction was substantial (ρc = 0.964), but the ρc of the BPD prediction was moderate (ρc = 0.920). Both the model and BPD predictions had greater differences from the reference standard at increasing gestational age. However, the upper limit of the model's prediction (2.45 weeks) was significantly shorter than that of BPD (5.62 weeks). CONCLUSIONS: Deep learning can accurately predict gestational age from fetal brain MR acquired after the first trimester. KEY POINTS: • The prediction of gestational age using ultrasound is accurate in the first trimester but becomes inaccurate as gestational age increases. • Deep learning can accurately predict gestational age from fetal brain MRI acquired in the second and third trimester. • Prediction of gestational age by deep learning may have benefits for prenatal care in pregnancies that are underserved during the first trimester.

    2021年06月, European radiology, 31 (6), 3775 - 3782, 英語, 国際誌

    研究論文(学術雑誌)

  • Masakatsu Tsurusaki, Keitaro Sofue, Hiromitsu Onishi, Satoshi Goshima, Atsushi Higaki, Hiroyoshi Isoda, Hiroki Haradome, Kazunari Ishii, Takamichi Murakami

    2021年04月, Japanese journal of radiology, 39 (4), 405 - 405, 英語, 国内誌

  • Yoshiko Ueno, Tsutomu Tamada, Mitsuru Takeuchi, Keitaro Sofue, Satoru Takahashi, Yuki Kamishima, Yasuyo Urase, Ayumu Kido, Nobuyuki Hinata, Kenichi Harada, Masato Fujisawa, Yoshiyuki Miyaji, Takamichi Murakami

    BACKGROUND. The Vesical Imaging Reporting and Data System (VI-RADS), based on multiparametric MRI (mpMRI), was developed to provide accurate information for the diagnosis of muscle-invasive bladder cancer (MIBC). OBJECTIVE. The purpose of our study was to evaluate the interobserver agreement and diagnostic performance of VI-RADS among readers with different levels of experience. METHODS. This retrospective study included 91 consecutive patients who underwent mpMRI before transurethral resection of bladder tumor (TURBT) from July 2010 through August 2018. After attending a training session, seven radiologists (five radiologists experienced in bladder MRI and two inexperienced radiologists) reviewed and scored all MRI examinations according to VI-RADS. The interobserver agreement was assessed by kappa statistics. ROC analysis was used to evaluate the diagnostic performance for MIBC. AUCs were estimated. RESULTS. Among 91 patients (72 men and 19 women; mean age ± SD, 73.2 ± 10.2 years), 48 (52.7%) had MIBC and 43 (47.3%) had non-muscle-invasive bladder cancer. Sixty-eight patients were treated with TURBT, and 23 were treated with radical cystectomy. Interobserver agreement was moderate to substantial (κ = 0.60-0.80) among the experienced readers, substantial (κ = 0.67) between the two inexperienced readers, and moderate to substantial (κ = 0.55-0.75) between the experienced and inexperienced readers. The pooled AUC was 0.88 (range, 0.82-0.91) for experienced readers and 0.84 (range, 0.83-0.85) for inexperienced readers, and 0.87 for all readers. Using a VI-RADS score of 4 or greater as the cutoff value for MIBC, the pooled sensitivity and specificity were 74.1% (range, 66.0-80.9%) and 94.1% (range, 88.6-97.7%) for experienced readers and 63.9% (range, 59.6-68.1%) and 86.4% (range, 84.1-88.6%) for inexperienced readers. Using a VI-RADS score of 3 or greater as the cutoff value, the pooled sensitivity and specificity were 83.4% (range, 80.9-85.1%) and 77.3% (range, 61.4-88.6%) for experienced readers and 82.0% (range, 80.9-83.0%) and 73.9% (range, 72.7-75.0%) for inexperienced readers. CONCLUSION. We observed moderate to substantial interobserver agreement and a pooled AUC of 0.87 among radiologists of different levels of expertise using VI-RADS. CLINICAL IMPACT. VI-RADS could help determine the depth and range of excision in TURBT, decreasing the risk of complications and enhancing the accuracy of pathologic diagnosis.

    2021年03月24日, AJR. American journal of roentgenology, 216 (5), 1 - 10, 英語, 国際誌

    研究論文(学術雑誌)

  • Koji Maruyama, Takuya Okada, Takeshi Ueha, Kayako Isohashi, Hayato Ikeda, Yasukazu Kanai, Koji Sasaki, Tomoyuki Gentsu, Eisuke Ueshima, Keitaro Sofue, Munenobu Nogami, Masato Yamaguchi, Koji Sugimoto, Yoshitada Sakai, Jun Hatazawa, Takamichi Murakami

    Carbon dioxide (CO2) treatment is reported to have an antitumor effect owing to the improvement in intratumoral hypoxia. Previous studies were based on histological analysis alone. In the present study, the improvement in intratumoral hypoxia by percutaneous CO2 treatment in vivo was determined using 18F-fluoromisonidazole positron emission tomography-computed tomography (18F-FMISO PET-CT) images. Twelve Japanese nude mice underwent implantation of LM8 tumor cells in the dorsal subcutaneous area 2 weeks before percutaneous CO2 treatment and 18F-FMISO PET-CT scans. Immediately after intravenous injection of 18F-FMISO, CO2 and room air were administered transcutaneously in the CO2-treated group (n=6) and a control group (n=6), respectively; each treatment was performed for 10 minutes. PET-CT was performed 2 h after administration of 18F-FMISO. 18F-FMISO tumor uptake was quantitatively evaluated using the maximum standardized uptake value (SUVmax), tumor-to-liver ratio (TLR), tumor-to-muscle ratio (TMR), metabolic tumor volume (MTV) and total lesion glycolysis (TLG). Mean ± standard error of the mean (SEM) of the tumor volume was not significantly different between the two groups (CO2-treated group, 1.178±0.450 cm3; control group, 1.368±0.295 cm3; P=0.485). Mean ± SEM of SUVmax, TLR, MTV (cm3) and TLG were significantly lower in the CO2-treated group compared with the control group (0.880±0.095 vs. 1.253±0.071, P=0.015; 1.063±0.147361 vs. 1.455±0.078, P=0.041; 0.353±0.139 vs. 1.569±0.438, P=0.015; 0.182±0.070 vs. 1.028±0.338, P=0.015), respectively. TMR was not significantly different between the two groups (4.520±0.503 vs. 5.504±0.310; P=0.240). In conclusion, 18F-FMISO PET revealed that percutaneous CO2 treatment improved intratumoral hypoxia in vivo. This technique enables assessment of the therapeutic effect in CO2 treatment by imaging, and may contribute to its clinical application.

    2021年03月, Oncology letters, 21 (3), 207 - 207, 英語, 国際誌

    研究論文(学術雑誌)

  • Masakatsu Tsurusaki, Keitaro Sofue, Hiromitsu Onishi, Satoshi Goshima, Atsushi Higaki, Hiroyoshi Isoda, Hiroki Haradome, Kazunari Ishii, Takamichi Murakami

    PURPOSE: To identify predictive factors for truncation artifacts (TAs) in the arterial phase of Gd-EOB-DTPA-enhanced MRI in a multicenter study in Japan. MATERIALS AND METHODS: Data on patient factors (age, sex, weight, presence of viral hepatitis, and other conditions) and imaging parameters (e.g., triggering, voxel size, matrix, k-space ordering, acquisition time, reduction factor, flip angle, fat suppression, field strength, injection rate, and saline volume) were obtained. Univariate and multivariate analyses were performed to investigate the correlation of these parameters. RESULTS: We evaluated 1444 patients from 43 institutions who were scanned using GE, Siemens, Philips, or Toshiba MRI equipment (501, 354, 349, and 240 patients, respectively). The total incidence of TAs was 12.5% (17.2, 3.6, 15.7, and 12.1%, respectively). The matrix [odds ratio (OR) 0.13], flip angle (OR 5.77), use of fat suppression (OR 0.106), and field strength (OR 0.092) used in the Philips equipment significantly increased the incidence of TAs in MRI examination. CONCLUSIONS: The incidence of TAs in the arterial phase is influenced by several patient factors and imaging parameters. Especially, Siemens and Toshiba equipment had a significantly lower frequency of TAs. This indicates that such vendor-specific technology used in the dynamic sequence may have a TA-resistant effect.

    2021年02月, Japanese journal of radiology, 39 (2), 165 - 177, 英語, 国内誌

    研究論文(学術雑誌)

  • Masakatsu Tsurusaki, Keitaro Sofue, Masatoshi Hori, Kosuke Sasaki, Kazunari Ishii, Takamichi Murakami, Masatoshi Kudo

    Dual-energy computed tomography (DECT) is an imaging technique based on data acquisition at two different energy settings. Recent advances in CT have allowed data acquisitions and simultaneous analyses of X-rays at two energy levels, and have resulted in novel developments in the field of abdominal imaging. The use of low and high X-ray tube voltages in DECT provide fused images that improve the detection of liver tumors owing to the higher contrast-to-noise ratio (CNR) of the tumor compared with the liver. The use of contrast agents in CT scanning improves image quality by enhancing the CNR and signal-to-noise ratio while reducing beam-hardening artifacts. DECT can improve detection and characterization of hepatic abnormalities, including mass lesions. The technique can also be used for the diagnosis of steatosis and iron overload. This article reviews and illustrates the different applications of DECT in liver imaging.

    2021年01月22日, Diagnostics (Basel, Switzerland), 11 (2), 英語, 国際誌

    研究論文(学術雑誌)

  • Takeshi Tanaka, Atsuhiro Masuda, Keitaro Sofue, Hirochika Toyama, Hideyuki Shiomi, Arata Sakai, Takashi Kobayashi, Shunta Tanaka, Ryota Nakano, Yasutaka Yamada, Shigeto Ashina, Masahiro Tsujimae, Kohei Yamakawa, Shohei Abe, Masanori Gonda, Shigeto Masuda, Noriko Inomata, Hisahiro Uemura, Shinya Kohashi, Kae Nagao, Maki Kanzawa, Tomoo Itoh, Takumi Fukumoto, Yuzo Kodama

    BACKGROUND: Intraductal papillary mucinous neoplasm (IPMN) of the pancreas is associated with acute pancreatitis (AP) in some cases, however its causes have not been fully elucidated. We investigated the association of the incidence of AP with epithelial subtypes and pancreatic volume in IPMN. METHODS: This retrospective study included 182 consecutive surgically resected IPMN patients between January 2000 and December 2018. The relationship between the incidence of AP and epithelial subtypes of IPMN and pancreatic volume was investigated. Epithelial subtypes of IPMN were classified into gastric (G type: N = 116), intestinal (I type: N = 49), pancreatobiliary (PB type: N = 14), and oncocytic types (O type: N = 3). Pancreatic volume of the contrast-enhanced computed tomography scan was measured using Ziostation2 software. Histological pancreatic parenchymal atrophy was also evaluated. RESULTS: AP occurred more frequently in I-types (I-type vs. G-type, 22.4% [11/49] vs 3.4% [4/116], P = 0.003) and PB-types (PB type vs. G-type, 35.7% [5/14] vs. 3.4% [4/116], P = 0.007) in comparison with G-types, which constituted the majority of the resected IPMNs. AP occurred more frequently in I-type patients with high pancreatic volumes (I-type with high pancreatic volume vs. I-type with low pancreatic volume, 37.0% [10/27] vs. 4.7% [1/21], P = 0.02). However, histological atrophy did not show an additional influence on the association between the incidence of AP and epithelial subtypes. The elevation of serum pancreatic enzymes was not significantly related to epithelial subtypes. CONCLUSION: Epithelial subtypes and the degree of pancreatic volume may be closely associated with the incidence of AP in IPMN.

    2021年01月, Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 21 (1), 138 - 143, 英語, 国際誌

    研究論文(学術雑誌)

  • Munenobu Nogami, Feibi Zeng, Junko Inukai, Yoshiaki Watanabe, Mizuho Nishio, Tomonori Kanda, Yoshiko R Ueno, Keitaro Sofue, Atsushi K Kono, Masatoshi Hori, Akihito Ohnishi, Kazuhiro Kubo, Takako Kurimoto, Takamichi Murakami

    PURPOSE: To retrospectively assess the repeatability of physiological F-18 labeled fluorodeoxyglucose (FDG) uptake in the skin on positron emission tomography/magnetic resonance imaging (PET/MRI) and explore its regional distribution and relationship with sex and age. METHODS: Out of 562 examinations with normal FDG distribution on whole-body PET/MRI, 74 repeated examinations were evaluated to assess the repeatability and regional distribution of physiological skin uptake. Furthermore, 224 examinations were evaluated to compare differences in the uptake due to sex and age. Skin segmentation on PET was performed as body-surface contouring on an MR-based attenuation correction map using an off-line reconstruction software. Bland-Altman plots were created for the repeatability assessment. Kruskal-Wallis test was performed to compare the maximum standardized uptake value (SUVmax) with regional distribution, age, and sex. RESULTS: The limits of agreement for the difference in SUVmean and SUVmax of the skin were less than 30%. The highest SUVmax was observed in the face (3.09±1.04), followed by the scalp (2.07±0.53). The SUVmax in the face of boys aged 0-9 years and 10-20 years (1.33±0.64 and 2.05±1.00, respectively) and girls aged 0-9 years (0.98±0.38) was significantly lower than that of men aged ≥20 years and girls aged ≥10 years (p<0.001). In women, the SUVmax of the face (2.31±0.71) of ≥70-year-olds was significantly lower than that of 30-39-year-olds (3.83±0.82) (p<0.05). CONCLUSION: PET/MRI enabled the quantitative analysis of skin FDG uptake with repeatability. The degree of physiological FDG uptake in the skin was the highest in the face and varied between sexes. Although attention to differences in body habitus between age groups is needed, skin FDG uptake also depended on age.

    2021年, PloS one, 16 (3), e0249304, 英語, 国際誌

    研究論文(学術雑誌)

  • Hiroki Horinouchi, Eisuke Ueshima, Keitaro Sofue, Shohei Komatsu, Takuya Okada, Masato Yamaguchi, Takumi Fukumoto, Koji Sugimoto, Takamichi Murakami

    BACKGROUND: Postoperative biliary strictures are commonly related to accidental bile duct injuries or occur at the site of biliary anastomosis. The first-line treatment for benign biliary strictures is endoscopic therapy, which is less invasive and repeatable. However, recanalization for biliary complete obstruction is technically challenging to treat. The present report describes a successful case of treatment by extraluminal recanalization for postoperative biliary obstruction using a transseptal needle. CASE PRESENTATION: A 66-year-old woman had undergone caudal lobectomy for the treatment of hepatocellular carcinoma. The posterior segmental branch of the bile duct was injured and repaired intraoperatively. Three months after the surgery, the patient had developed biliary leakage from the right hepatic bile duct, resulting in complete biliary obstruction. Since intraluminal recanalization with conventional endoscopic and percutaneous approaches with a guidewire failed, extraluminal recanalization using a transseptal needle with an internal lumen via percutaneous approach was performed under fluoroscopic guidance. The left lateral inferior segmental duct was punctured, and an 8-F transseptal sheath was introduced into the ostium of right hepatic duct. A transseptal needle was advanced, and the right hepatic duct was punctured by targeting an inflated balloon that was placed at the end of the obstructed right hepatic bile duct. After confirming successful puncture using contrast agent injected through the internal lumen of the needle, a 0.014-in. guidewire was advanced into the right hepatic duct. Finally, an 8.5-F internal-external biliary drainage tube was successfully placed without complications. One month after the procedure, the drainage tube was replaced with a 10.2-F drainage tube to dilate the created tract. Subsequent endoscopic internalization was performed 5 months after the procedure. At the 1-year follow-up examination, there was no sign of biliary obstruction and recurrence of hepatocellular carcinoma. CONCLUSIONS: Recanalization using a transseptal needle can be an alternative technique for rigid biliary obstruction when conventional techniques fail.

    2020年12月03日, Surgical case reports, 6 (1), 304 - 304, 英語, 国際誌

    研究論文(学術雑誌)

  • Yuta Akamine, Yu Ueda, Yoshiko Ueno, Keitaro Sofue, Takamichi Murakami, Masami Yoneyama, Makoto Obara, Marc Van Cauteren

    PURPOSE: Hierarchical clustering (HC), an unsupervised machine learning (ML) technique, was applied to multi-parametric MR (mp-MR) for prostate cancer (PCa). The aim of this study is to demonstrate HC can diagnose PCa in a straightforward interpretable way, in contrast to deep learning (DL) techniques. METHODS: HC was constructed using mp-MR including intravoxel incoherent motion, diffusion kurtosis imaging, and dynamic contrast-enhanced MRI from 40 tumor and normal tissues in peripheral zone (PZ) and 23 tumor and normal tissues in transition zone (TZ). HC model was optimized by assessing the combinations of several dissimilarity and linkage methods. Goodness of HC model was validated by internal methods. RESULTS: Accuracy for differentiating tumor and normal tissue by optimal HC model was 96.3% in PZ and 97.8% in TZ, comparable to current clinical standards. Relationship between input (DWI and permeability parameters) and output (tumor and normal tissue cluster) was shown by heat maps, consistent with literature. CONCLUSION: HC can accurately differentiate PCa and normal tissue, comparable to state-of-the-art diffusion based parameters. Contrary to DL techniques, HC is an operator-independent ML technique producing results that can be interpreted such that the results can be knowledgeably judged.

    2020年12月, Magnetic resonance imaging, 74, 90 - 95, 英語, 国際誌

    研究論文(学術雑誌)

  • 肺病変に関するPET/MRIにおけるZero-TE法の診断能について

    Zeng Feibi, 野上 宗伸, 犬養 純子, 上野 嘉子, 神田 知紀, 祖父江 慶太郎, 久保 和広, 栗本 貴子, 村上 卓道

    (一社)日本核医学会, 2020年10月, 核医学, 57 (Suppl.), S155 - S155, 英語

  • 悪性腫瘍の全身FDG PET/MRIにおけるBSREMを用いた高速撮像と診断能の検討

    犬養 純子, 野上 宗伸, 曽 菲比, 渡邊 慶明, 西尾 瑞穂, 神田 知紀, 祖父江 慶太郎, 河野 敦, 久保 和広, 村上 卓道

    (一社)日本核医学会, 2020年10月, 核医学, 57 (Suppl.), S174 - S174, 日本語

  • 肺病変に関するPET/MRIにおけるZero-TE法の診断能について

    Zeng Feibi, 野上 宗伸, 犬養 純子, 上野 嘉子, 神田 知紀, 祖父江 慶太郎, 久保 和広, 栗本 貴子, 村上 卓道

    (一社)日本核医学会, 2020年10月, 核医学, 57 (Suppl.), S155 - S155, 英語

  • 悪性腫瘍の全身FDG PET/MRIにおけるBSREMを用いた高速撮像と診断能の検討

    犬養 純子, 野上 宗伸, 曽 菲比, 渡邊 慶明, 西尾 瑞穂, 神田 知紀, 祖父江 慶太郎, 河野 敦, 久保 和広, 村上 卓道

    (一社)日本核医学会, 2020年10月, 核医学, 57 (Suppl.), S174 - S174, 日本語

  • 治療適応の基準を満たさない腎血管筋脂肪腫の破裂

    元津 倫幸, 山口 雅人, 佐々木 康二, Hamada M.A.S., 上嶋 英介, 岡田 卓也, 祖父江 慶太郎, 杉本 幸司, 村上 卓道

    (公社)日本医学放射線学会, 2020年10月, 日本医学放射線学会秋季臨床大会抄録集, 56回, S144 - S144, 日本語

  • Yushi Tsujita, Keitaro Sofue, Shohei Komatsu, Takeru Yamaguchi, Eisuke Ueshima, Yoshiko Ueno, Tomonori Kanda, Takuya Okada, Munenobu Nogami, Masato Yamaguchi, Masakatsu Tsurusaki, Masatoshi Hori, Takumi Fukumoto, Takamichi Murakami

    PURPOSE: Accurate prediction of post-hepatectomy liver failure (PHLF) is important in advanced hepatocellular carcinoma (HCC). We aimed to retrospectively evaluate the utility of gadoxetic acid-enhanced MRI for predicting PHLF in patients who underwent anatomic hepatectomy for HCC with portal vein invasion. METHODS: Forty-one patients (32 men, 9 women) were included. Hepatobiliary-phase MR images were acquired 20 min after injection of gadoxetic acid using a 3D fat-suppressed T1-weighted spoiled gradient-echo sequence. Liver-spleen ratio (LSR), remnant hepatocellular uptake index (rHUI), and HUI were calculated. The severity of PHLF was defined according to the International Study Group of Liver Surgery. Differences in LSR between the resected liver and the remnant liver, and HUI and rHUI/HUI between no/mild and severe PHLF were compared using the Wilcoxon signed-rank test and Wilcoxon rank-sum test, respectively. Univariate and multivariate logistic regression analyses were performed to identify predictors of severe PHLF. Areas under the receiver operating characteristic curves (AUCs) of rHUI and rHUI/HUI were calculated for predicting severe PHLF. RESULTS: Nine patients developed severe PHLF. LSR of the remnant liver was significantly higher than that of the resected liver (P < 0.001). Severe PHLF demonstrated significantly lower rHUI (P < 0.001) and rHUI/HUI (P < 0.001) compared with no/mild PHLF. Multivariate logistic regression analysis showed that decreased rHUI (P = 0.012, AUC=0.885) and rHUI/HUI (P = 0.002, AUC=0.852) were independent predictors of severe PHLF. CONCLUSION: Gadoxetic acid-enhanced MRI can be a promising noninvasive examination for assessing global and regional liver function, allowing estimation of the functional liver remnant and accurate prediction of severe PHLF before hepatic resection.

    2020年09月, European journal of radiology, 130, 109189 - 109189, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Yasutaka Yamada, Atsuhiro Masuda, Keitaro Sofue, Eisuke Ueshima, Hideyuki Shiomi, Arata Sakai, Takashi Kobayashi, Takuya Ikegawa, Shunta Tanaka, Ryota Nakano, Takeshi Tanaka, Maya Kakihara, Shigeto Ashina, Masahiro Tsujimae, Kohei Yamakawa, Shohei Abe, Masanori Gonda, Shigeto Masuda, Noriko Inomata, Hiromu Kutsumi, Tomoo Itoh, Takamichi Murakami, Yuzo Kodama

    Background and Aims: Imaging tools for predicting pancreatic atrophy after steroid therapy in autoimmune pancreatitis (AIP) have not been established. As delayed equilibrium-phase contrast enhancement in computed tomography (CE-CT) may reflect interstitial fibrosis, we evaluated the ability of equilibrium-phase CT imaging for predicting pancreatic atrophy. Methods: Forty-six steroid-treated AIP patients who underwent contrast-enhanced CT at our university hospital were included in this retrospective study. CT attenuation (Hounsfield units [HU]) values in noncontrast images (NC) and equilibrium-phase images (EP) and the differences in HU values between NC and EP images (SUB) were measured. Pancreatic volume was measured in CE-CT before (Volpre) and after (Volpost) steroid therapy. The volume reduction rate was calculated. The relationships of CT values with pancreatic atrophy, Volpost, volume reduction rate, and diabetes exacerbation were investigated. Results: CT values in the EP and SUB images before steroid therapy were associated with pancreatic atrophy after steroid therapy (atrophy vs nonatrophy 114.5 ± 12.8 vs 99.5 ± 11.1, P = 0.0002; 70.9 ± 14.72 vs 57.2 ± 13.1, P = 0.003, respectively), but CT values in NC images were not (P = 0.42). CT values in EP and SUB images before steroid therapy were correlated with Volpost (EP images r = -0.70, P = 0.002; SUB images r = -0.68, P = 0.03) and volume reduction rate after steroid therapy (EP images: r = -0.55, P < 0.0001; SUB images r = -0.45, P = 0.002). Diabetes exacerbation was associated with higher EP and SUB values (P = 0.009 and P = 0.04, respectively). Conclusion: Equilibrium-phase contrast CT imaging may facilitate prediction of pancreatic atrophy after steroid therapy in AIP.

    2020年08月, JGH open : an open access journal of gastroenterology and hepatology, 4 (4), 677 - 683, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • 液体塞栓物質(NBCA)を極める! エキスパートへの道 膵領域の急性出血に対するNBCAを用いた動脈塞栓術の検討

    佐々木 康二, 岡田 卓也, 山口 雅人, Hamada Mostafa, 元津 倫幸, 上嶋 英介, 祖父江 慶太郎, 杉本 幸司, 村上 卓道

    (一社)日本インターベンショナルラジオロジー学会, 2020年08月, 日本インターベンショナルラジオロジー学会雑誌, 35 (Suppl.), 122 - 122, 日本語

  • ドセタキセル含浸薬剤溶出性ビーズの基礎的検討

    谷 龍一郎, 岡田 卓也, 上嶋 英介, 篠原 正和, 元津 倫幸, 佐々木 康二, Hamada M.A.S, 祖父江 慶太郎, 山口 雅人, 杉本 幸司, 村上 卓道

    (一社)日本インターベンショナルラジオロジー学会, 2020年08月, 日本インターベンショナルラジオロジー学会雑誌, 35 (Suppl.), 282 - 282, 日本語

  • Yasuyo Urase, Mizuho Nishio, Yoshiko Ueno, Atsushi K. Kono, Keitaro Sofue, Tomonori Kanda, Takaki Maeda, Munenobu Nogami, Masatoshi Hori, Takamichi Murakami

    The usefulness of sparse-sampling CT with deep learning-based reconstruction for detection of metastasis of malignant ovarian tumors was evaluated. We obtained contrast-enhanced CT images (n = 141) of ovarian cancers from a public database, whose images were randomly divided into 71 training, 20 validation, and 50 test cases. Sparse-sampling CT images were calculated slice-by-slice by software simulation. Two deep-learning models for deep learning-based reconstruction were evaluated: Residual Encoder-Decoder Convolutional Neural Network (RED-CNN) and deeper U-net. For 50 test cases, we evaluated the peak signal-to-noise ratio (PSNR) and structural similarity (SSIM) as quantitative measures. Two radiologists independently performed a qualitative evaluation for the following points: entire CT image quality; visibility of the iliac artery; and visibility of peritoneal dissemination, liver metastasis, and lymph node metastasis. Wilcoxon signed-rank test and McNemar test were used to compare image quality and metastasis detectability between the two models, respectively. The mean PSNR and SSIM performed better with deeper U-net over RED-CNN. For all items of the visual evaluation, deeper U-net scored significantly better than RED-CNN. The metastasis detectability with deeper U-net was more than 95%. Sparse-sampling CT with deep learning-based reconstruction proved useful in detecting metastasis of malignant ovarian tumors and might contribute to reducing overall CT-radiation exposure.

    MDPI AG, 2020年06月28日, Applied Sciences, 10 (13), 4446 - 4446

    研究論文(学術雑誌)

  • Hiroki Horinouchi, Takuya Okada, Masato Yamaguchi, Koji Maruyama, Koji Sasaki, Tomoyuki Gentsu, Eisuke Ueshima, Keitaro Sofue, Ryota Kawasaki, Yoshikatsu Nomura, Atsushi Omura, Kenji Okada, Koji Sugimoto, Takamichi Murakami

    PURPOSE: To evaluate the mid-term outcomes of transarterial embolization (TAE) for type II endoleak after endovascular abdominal aortic aneurysm repair (EVAR) and investigate the predictors of sac enlargement after embolization. MATERIALS AND METHODS: We conducted a retrospective analysis of 55 patients [48 men and 7 women, median age 79.0 (interquartile ranges 74-82) years] who underwent TAE for type II endoleak from 2010 to 2018. The aneurysmal sac enlargement, endoleaks, aneurysm-related adverse event rate, and reintervention rate were evaluated. Patients' characteristics and clinical factors were evaluated for their association with sac enlargement. RESULTS: Fifty-five patients underwent TAE with technical success and were subsequently followed for a median of 636 (interquartile ranges 446-1292) days. The freedom from sac enlargement rates at 1, 3, and 5 years was 73.2%, 32.0%, and 26.7%, respectively. After initial TAE, the recurrent type II, delayed type I, and occult type III endoleak were identified in 39 (71%), 5 (9%), and 3 (5%) patients, respectively. Although a patient had aorto-duodenal fistula, there was no aneurysm-related death. The freedom from reintervention rates was 84.6%, 35.7%, and 17.0%, respectively. In the multivariate analysis, sac diameter > 55 mm at initial TAE (hazard ratios, 3.23; 95% confidence intervals, 1.22-8.58; P < 0.05) was a significant predictor of sac enlargement. CONCLUSION: TAE for type II endoleak was not effective in preventing sac enlargement, and reinterventions were required among the mid-term follow-up. The sac diameter > 55 mm at initial TAE was a significant predictor of sac enlargement.

    2020年05月, Cardiovascular and interventional radiology, 43 (5), 696 - 705, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Hiroki Horinouchi, Keitaro Sofue, Tatsuya Nishii, Koji Maruyama, Koji Sasaki, Tomoyuki Gentsu, Eisuke Ueshima, Takuya Okada, Masato Yamaguchi, Koji Sugimoto, Takamichi Murakami

    PURPOSE: To assess the utility of whole-aorta CT angiography (CTA) with 15 mL contrast material (CM) on time-resolved imaging for endovascular abdominal aortic repair (EVAR). METHODS: Twenty-six patients with a high-risk of post-contrast acute kidney injury (PC-AKI) underwent CTA with 15 mL CM using temporal maximum intensity projection (tMIP-CTA) generated from time-resolved imaging. The aortoiliac CT values were measured. Two observers measured the arterial diameters in unenhanced CT and tMIP-CTA images, and image quality was evaluated on a 5-point scale. The presence of the accessory renal artery, inferior mesenteric artery (IMA) occlusion, and instructions for use (IFU) of EVAR were evaluated. RESULTS: CT examinations were successfully performed, and no patients developed PC-AKI. The mean CT values of the whole aorta were 267.5 ± 51.4 HU, which gradually decreased according to the distal levels of the aorta. Bland-Altman analysis revealed excellent agreement for the external arterial diameter measurements between unenhanced CT and tMIP-CTA. Excellent interobserver agreement was achieved for the measurements of the external (ICCs, 0.910-0.992) and internal arterial diameters (ICCs, 0.895-0.993). Excellent or good overall image quality was achieved in 24 (92 %) patients. The presence of the accessory renal artery, IMA occlusion and the assessment of IFU were in 100 % agreement. Multivariate analysis revealed aortic volume as the most significant independent factor associated with strong aortic enhancement (p = 0.004). CONCLUSIONS: Whole-aorta tMIP-CTA on time-resolved imaging is useful for maintaining contrast enhancement and image quality for EVAR planning, and can substantially reduce the amount of CM.

    2020年05月, European journal of radiology, 126, 108861 - 108861, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Feibi Zeng, Munenobu Nogami, Yoshiko R Ueno, Tomonori Kanda, Keitaro Sofue, Kazuhiro Kubo, Takako Kurimoto, Takamichi Murakami

    OBJECTIVES: This study aimed to evaluate the diagnostic performance of the lung zero-echo time (ZTE) sequence in FDG PET/MRI for detection and differentiation of lung lesions in oncologic patients in comparison with conventional two-point Dixon-based MR imaging. METHODS: In this single-institution retrospective study approved by the institutional review board, 209 patients with malignancies (97 men and 112 women; age range, 17-89 years; mean age, 66.5 ± 12.9 years) underwent 18F-FDG PET/MRI between August 2017 and August 2018, with diagnostic Dixon and ZTE under respiratory gating acquired simultaneously with PET. Image analysis was performed for PET/Dixon and PET/ZTE fused images by two readers to assess the detectability and differentiation of lung lesions. The reference standard was pathological findings and/or the data from a chest CT. The detection and differentiation abilities were evaluated for all lesions and subgroups divided by lesion size and maximum standardized uptake value (SUVmax). RESULTS: Based on the reference standard, 227 lung lesions were identified in 113 patients. The detectability of PET/ZTE was significantly better than that of PET/Dixon for overall lesions, lesions with a SUVmax less than 3.0 and lesions smaller than 4 mm (p < 0.01). The diagnostic performance of PET/ZTE was significantly better than that of PET/Dixon for overall lesions and lesions smaller than 4 mm (p < 0.01). CONCLUSIONS: ZTE can improve diagnostic performance in the detection and differentiation of both FDG-avid and non-FDG-avid lung lesions smaller than 4 mm in size, yielding a promising tool to enhance the utility of FDG PET/MRI in oncology patients with lung lesions. KEY POINTS: • The detection rate of PET/ZTE for lesions with a SUVmax of less than 1.0 was significantly better than that of PET/Dixon. • The performance for differentiation of PET/ZTE for lesions that were even smaller than 4 mm in size were significantly better than that of PET/Dixon. • Inter-rater agreement of PET/ZTE for the differentiation of lesions less than 4 mm in size was substantial and better than that of PET/Dixon.

    2020年04月16日, European radiology, 30 (9), 4995 - 5003, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Tai K, Komatsu S, Sofue K, Kido M, Tanaka M, Kuramitsu K, Awazu M, Gon H, Tsugawa D, Yanagimoto H, Toyama H, Murakami S, Murakami T, Fukumoto T

    BACKGROUND: Although total tumour volume (TTV) may have prognostic value for hepatic resection in certain solid cancers, its importance in colorectal liver metastases (CRLM) remains unexplored. This study investigated its prognostic value in patients with resectable CRLM. METHOD: This was a retrospective review of patients who underwent hepatic resection for CRLM between 2008 and 2017 in a single institution. TTV was measured from CT images using three-dimensional construction software; cut-off values were determined using receiver operating characteristic (ROC) curve analyses. Potential prognostic factors, overall survival (OS) and recurrence-free survival (RFS) were determined using multivariable and Kaplan-Meier analyses. RESULTS: Some 94 patients were included. TTV cut-off values for OS and RFS were 100 and 10 ml respectively. Right colonic primary tumours, primary lymph node metastasis and bilobar liver metastasis were included in the multivariable analysis of OS; a TTV of 100 ml or above was independently associated with poorer OS (hazard ratio (HR) 6·34, 95 per cent c.i. 2·08 to 17·90; P = 0·002). Right colonic primary tumours and primary lymph node metastasis were included in the RFS analysis; a TTV of 10 ml or more independently predicted poorer RFS (HR 1·90, 1·12 to 3·57; P = 0·017). The 5-year OS rate for a TTV of 100 ml or more was 41 per cent, compared with 67 per cent for a TTV below 100 ml (P = 0·006). Corresponding RFS rates with TTV of 10 ml or more, or less than 10 ml, were 14 and 58 per cent respectively (P = 0·009). A TTV of at least 100 ml conferred a higher rate of unresectable initial recurrences (12 of 15, 80 per cent) after initial hepatic resection. CONCLUSION: TTV was associated with RFS and OS after initial hepatic resection for CRLM; TTV of 100 ml or above was associated with a higher rate of unresectable recurrence.

    2020年04月11日, BJS open[Epub ahead of print], 英語, 国際誌

    [査読有り]

  • Keitaro Sofue, Minori Onoda, Masakatsu Tsurusaki, Daisuke Morimoto, Norihisa Yada, Masatoshi Kudo, Takamichi Murakami

    BACKGROUND: Differentiation between inflammation and fibrosis is an important clinical distinction in patients with chronic liver disease, which has been difficult so far with MR elastography. PURPOSE: To investigate whether dual-frequency MR elastography can estimate necroinflammation of the liver and improve diagnostic performance for the staging of liver fibrosis. STUDY TYPE: Retrospective. SUBJECTS: In all, 30 patients (14 males, 16 females) with chronic liver disease. FIELD STRENGTH/SEQUENCE: 1.5T/dual-frequency MR elastography at 60-Hz and 80-Hz vibration frequencies. [Correction added on November 12, 2019, after first online publication: The field strength in the preceding sentence was corrected.] ASSESSMENT: Necroinflammation activity and fibrosis were assessed using the METAVIR scoring system. Stiffness values at 60-Hz (G60-Hz ) and 80-Hz (G80-Hz ) were obtained with an MR elastogram. The difference value between G80-Hz and G60-Hz (ΔG) was calculated. Four values (G60-Hz , G80-Hz , G60-Hz - ΔG, and G80-Hz  + ΔG) were generated to estimate necroinflammation and fibrosis. STATISTICAL TESTS: The ΔG were correlated with necroinflammation activity grade and fibrosis stage using Spearman's rank correlation. Diagnostic performance of the four values for necroinflammation activity grade and fibrous stage was assessed by using area under the receiver operating characteristic curve (AUC). RESULTS: The mean value of G80-Hz (6.23 ± 3.67 kPa) was significantly higher than that of G60-Hz (5.27 ± 3.14 kPa) (P < 0.0001). The ΔG demonstrated a strong correlation with necroinflammation grade (ρ = 0.625, P < 0.001) and no correlation with fibrosis stage (ρ = 0.306, P = 0.113). The AUC of the G80-Hz and G80-Hz  + ΔG showed higher accuracy for necroinflammation, and optimal cutoff values yielded better discrimination of ≥A1, ≥A2, and = A3. The AUC demonstrated that all the generated values had high diagnostic performance (≥0.87 for all) for fibrosis. DATA CONCLUSION: Dual-frequency MR elastography shows potential in estimating necroinflammation of the liver and may improve diagnostic performance for staging liver fibrosis. LEVEL OF EVIDENCE: 3 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2020;51:1053-1064.

    2020年04月, Journal of magnetic resonance imaging : JMRI, 51 (4), 1053 - 1064, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Shohei Komatsu, Yoshihiko Yano, Keitaro Sofue, Masahiro Kido, Motofumi Tanaka, Kaori Kuramitsu, Masahide Awazu, Hidetoshi Gon, Atsushi Yamamoto, Hiroaki Yanagimoto, Hirochika Toyama, Yuzo Kodama, Takamichi Murakami, Takumi Fukumoto

    BACKGROUND: The present study aimed to assess the clinical features of patients who received lenvatinib treatment for unresectable hepatocellular carcinoma (HCC). METHODS: The clinical characteristics, adverse events, and radiological responses were evaluated for 51 consecutive patients. RESULTS: Of the study subjects, 37 patients had Child-Pugh class A (CPA) liver function, and 14 patients had Child-Pugh class B (CPB) liver function. The overall response rates in the CPA and CPB groups were 42.9% and 25.0%, respectively, and disease control rates were 82.9% and 83.3%, respectively, without significant difference (p = 0.2621 and 0.9697). There was no significant difference between CPA and CPB groups regarding the incidence of adverse events, except for hepatic coma. No significant difference was observed in the relative dose intensity between the CPA and CPB groups, for the first month, 1-2 months, or 2-3 months (p = 0.2368, 0.9368, and 0.9293). CONCLUSION: The comparable outcomes between the CPA and CPB groups suggest the acceptability of lenvatinib treatment in patients with impaired liver function, at least in the acute phase. With careful follow-up, the dose can be relatively intensified, even in patients with impaired liver function and this may contribute to offering comparable treatment.

    2020年03月29日, HPB : the official journal of the International Hepato Pancreato Biliary Association, 22 (10), 1450 - 1456, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • 線維軟骨塞栓症が疑われた若年者脊髄梗塞の1例

    藤原 康弘, 神田 知紀, 上野 嘉子, 岡田 卓也, 祖父江 慶太郎, 前田 隆樹, 野上 宗伸, 山口 雅人, 杉本 幸司, 村上 卓道, 大塚 喜久

    (公社)日本医学放射線学会, 2020年02月, Japanese Journal of Radiology, 38 (Suppl.), 40 - 40, 日本語

    [査読有り]

  • 若年者に発症した中枢神経カンジダ髄膜炎の1例

    山本 雄也, 神田 知紀, 上野 嘉子, 岡田 卓也, 祖父江 慶太郎, 前田 隆樹, 野上 宗伸, 山口 雅人, 杉本 幸司, 村上 卓道

    (公社)日本医学放射線学会, 2020年02月, Japanese Journal of Radiology, 38 (Suppl.), 45 - 45, 日本語

    [査読有り]

  • Kanda T, Miyazaki A, Zeng F, Ueno Y, Sofue K, Maeda T, Nogami M, Kitajima K, Murakami T

    The optic nerve is morphologically classified as a peripheral nerve, but histologically it shares characteristics with the central nerves. Diseases that affect vision and the optic nerve are many and varied: optic neuritis, demyelination (multiple sclerosis, acute disseminated encephalomyelitis, neuromyelitis optica spectrum disorder, and myelin oligodendrocyte glycoprotein antibody-related disorders), drugs, collagen disease, vasculitis, infection, trauma, vascular abnormalities, tumours, and non-tumoural masses. In this review, we summarise the magnetic resonance imaging findings for various pathological conditions that cause deterioration in visual acuity.

    INT SCIENTIFIC INFORMATION INC, 2020年02月, Polich Journal of Radiology, 85, e67 - e81, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • 消化器がん薬物療法up to date 当院でのレンバチニブ導入症例の検討

    小松 昇平, 矢野 嘉彦, 祖父江 慶太郎, 福本 巧

    日本消化器病学会-近畿支部, 2020年02月, 日本消化器病学会近畿支部例会プログラム・抄録集, 112回, 74 - 74, 日本語

  • Maruyama K, Sofue K, Horinouchi H, Okada T, Ueshima E, Gentsu T, Sasaki K, Yamaguchi M, Sugimoto K, Murakami T

    OBJECTIVE: The aim of this study was to assess the utility of 70-kilovoltage-peak (kVp) contrast-enhanced computed tomography (CECT) for visualization and identification of the right adrenal vein (RAV) in comparison with that of conventional 120-kVp CECT. METHODS: This retrospective study included patients who underwent adrenal venous sampling with concurrent biphasic 120-kVp (120-kVp group, n = 43) or 70-kVp (70-kVp group, n = 47) CECT. Signal-to-noise ratios, contrast-to-noise ratios, longitudinal lengths, conspicuity scores, RAV detection rates, and size-specific dose estimates were compared between the 2 groups. RESULTS: In comparison with the 120-kVp group, the 70-kVp group had significantly higher signal-to-noise and contrast-to-noise ratios (P < 0.001-P = 0.033), greater longitudinal lengths (P < 0.001-P = 0.002), superior conspicuity scores for the RAV (P < 0.001), higher RAV detection rates (P = 0.015-P = 0.033), and lower size-specific dose estimates (P < 0.001). CONCLUSIONS: Seventy-kilovoltage-peak CECT has advantages over conventional 120-kVp CECT and is potentially useful for noninvasive assessment of the precise anatomy of the RAV.

    2020年01月, J Comput Assist Tomogr, 44 (1), 153 - 159

    [査読有り]

    研究論文(学術雑誌)

  • Eisuke Ueshima, Hideyuki Nishiofuku, Haruyuki Takaki, Yutaka Hirata, Hiroshi Kodama, Toshihiro Tanaka, Kimihiko Kichikawa, Koichiro Yamakado, Takuya Okada, Keitaro Sofue, Masato Yamaguchi, Koji Sugimoto, Takamichi Murakami

    Introduction: The underlying mechanism involved in the recurrence of hepatoma after hepatic arterial embolization (HAE) is not adequately examined. An immunosuppressive cytokine, transforming growth factor β1 (TGF-β1), can lead to tumor progression and is affected by hypoxia in various cancers. The study aimed to assess the effect of HAE on the expression of TGF-β1 in a rat hepatoma model. Methods: Sprague-Dawley rats bearing N1S1 hepatoma cells underwent HAE (HAE group, n = 5) or sham treatment (sham group, n = 4). The animals were euthanized at 48 h, and liver tissues were harvested. Immunohistochemistry (IHC) and quantitative polymerase chain reaction (qPCR) were performed to compare the expression of TGF-β1 and hypoxia-inducible factor 1α (HIF-1α) between the HAE and sham groups. In vitro experiments with the N1S1 cell line were also performed under normoxic (21% O2) or hypoxic (1% O2) conditions for 48 h, and the expression of TGF-β1 and HIF-1α was assessed with western blotting and enzyme-linked immunosorbent assay. Statistical data comparisons were performed by Student t test. Results: IHC showed that both the TGF-β1-positive and HIF-1α-positive tumor peripheral areas were larger in the HAE group (6.59 ± 2.49 and 10.26 ± 4.14%; p < 0.001, respectively) than in the sham group (0.34 ± 0.41 and 0.40 ± 0.84% respectively). Similarly, qPCR showed that the mRNA expression levels of TGF-β1 and HIF-1α were higher (1.95 ± 0.38-fold and 1.62 ± 0.37-fold; p < 0.001 and p = 0.002, respectively) in the HAE group than those in the sham group. TGF-β1 expression was suppressed when HIF-1α inhibitors were added (p = 0.001), and HIF-1α expression was upregulated when exogenous TGF-β1 was added (p = 0.033) in N1S1 cells. Conclusion: HAE enhanced local TGF-β1 expression in a rat hepatoma model. In vitro experiments suggest that HAE-induced hypoxic stress may trigger the interdependent expression of TGF-β1 and HIF-1α.

    2020年01月, Liver cancer, 9 (1), 63 - 72, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Yoh Zen, Keitaro Sofue

    2019年12月, The American journal of surgical pathology, 43 (12), 1728 - 1731, 英語, 国際誌

    [査読有り]

  • 当院における脾動脈瘤に対する動脈塞栓術の治療成績

    岡田 卓也, 佐々木 康二, Hamada Mostafa, 堀之内 宏樹, 元津 倫幸, 上嶋 英介, 祖父江 慶太郎, 山口 雅人, 杉本 幸司, 村上 卓道

    (一社)日本脈管学会, 2019年10月, 脈管学, 59 (Suppl.), S140 - S140, 日本語

    [査読有り]

  • Iliac Branch Endoprosthesisを用いたステントグラフト内挿術の初期成績

    元津 倫幸, 山口 雅人, Hamada Mostafa, 佐々木 康二, 堀之内 宏樹, 上嶋 英介, 岡田 卓也, 祖父江 慶太郎, 後竹 康子, 中井 秀和, 山中 勝弘, 大村 篤史, 岡田 健次, 杉本 幸司, 村上 卓道

    (一社)日本脈管学会, 2019年10月, 脈管学, 59 (Suppl.), S175 - S175, 日本語

    [査読有り]

  • 難治性胆汁漏後の胆管狭窄に対して狭窄部穿刺が有効であった一例

    大宮 悟志, 小松 昇平, 祖父江 慶太郎, 上嶋 英介, 木戸 正浩, 田中 基文, 蔵満 薫, 粟津 正英, 権 英寿, 寺井 祥雄, 柳本 泰明, 外山 博近, 味木 徹夫, 杉本 幸司, 福本 巧

    日本臨床外科学会, 2019年10月, 日本臨床外科学会雑誌, 80 (増刊), 785 - 785, 日本語

    [査読有り]

  • Masahiro Tsujimae, Atsuhiro Masuda, Hideyuki Shiomi, Hirochika Toyama, Keitaro Sofue, Eisuke Ueshima, Kohei Yamakawa, Shigeto Ashina, Yasutaka Yamada, Takeshi Tanaka, Shunta Tanaka, Ryota Nakano, Yu Sato, Takuya Ikegawa, Manabu Kurosawa, Seiji Fujigaki, Takashi Kobayashi, Arata Sakai, Hiromu Kutsumi, Yoh Zen, Tomoo Itoh, Takumi Fukumoto, Yuzo Kodama

    BACKGROUND AND AIM: Chronic pancreatitis is a risk factor for pancreatic cancer. Pancreatic calcification is a characteristic of chronic pancreatitis; however, its significance for intraductal papillary mucinous neoplasm (IPMN) oncogenesis remains unknown. Therefore, we investigated the relationship between pancreatic calcification and invasive IPMN. METHODS: This study included 157 patients who underwent resection for IPMN between April 2001 and October 2016 (intraductal papillary mucinous adenoma, n = 76; noninvasive intraductal papillary mucinous carcinoma [IPMC], n = 32; and invasive IPMC, n = 49). We divided the subjects on the basis of the presence/absence of pancreatic calcification on preoperative computed tomography (CT). The factors associated with pancreatic calcification were investigated in univariate analyses. Then, multivariate logistic regression analyses of the relationship between pancreatic calcification and invasive IPMC (after adjusting for clinical or imaging characteristics) were conducted. RESULTS: Preoperative CT revealed pancreatic calcification in 17.2% (27/157) of the resected IPMN. In the univariate analyses, jaundice, high serum carbohydrate antigen 19-9 levels, and invasive IPMC were significantly associated with pancreatic calcification (4/27 [14.8%] vs 4/130 [3.1%], 0.01; 12/27 [44.4%] vs 31/130 [23.8%], 0.03; and 15/27 [55.6%] vs 34/130 [26.2%], 0.001, respectively). Pancreatic calcification was significantly associated with invasive IPMC (multivariate odds ratio = 2.88, 95% confidence interval [95% CI] = 1.15-7.21, 0.03, adjusted for clinical characteristics; odds ratio = 5.50, 95% CI = 1.98-15.3, 0.001, adjusted for imaging characteristics). CONCLUSIONS: Pancreatic calcification on CT is associated with invasive IPMC. Pancreatic calcification might be a predictor of invasive IPMC.

    2019年09月, Journal of gastroenterology and hepatology, 34 (9), 1648 - 1655, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Takashi Shimizu, Masayuki Akita, Keitaro Sofue, Hirochika Toyama, Tomoo Itoh, Takumi Fukumoto, Yoh Zen

    We recently experienced cases of pancreatobiliary-type intraductal papillary mucinous neoplasms (PB-IPMNs) with imaging features resembling pancreatic ductal adenocarcinomas (PDACs), and histologic appearance of purely pancreatobiliary morphology and highly distorted papillary growth, which led to the present study aiming to systematically investigate PB-IPMNs in comparison with PDACs. Surgical cases of PB-IPMNs (n = 31) and PDACs (n = 24) were examined. PB-IPMNs were classified into monotypic tumors (n = 12; 39%) consisting of entirely high-grade pancreatobiliary-type neoplastic cells and polytypic cases (n = 19; 61%) associated with components of low-grade dysplasia and/or other histologic types (eg, gastric, intestinal, or oncocytic types). Clinically, monotypic PB-IPMNs less commonly had dilatation of the ampullary orifice (0% versus 74%) and mucin hypersecretion (17% versus 89%) than did polytypic cases. In most cases of monotypic PB-IPMNs, cystic dilatation of the lesional ducts was less obvious on imaging; therefore, 33% were radiologically diagnosed as PDACs. Histologically, intraductal tumors in monotypic cases showed a highly complex papillary architecture with tubular/cribriform glands and irregular branching, and all these cases were associated with invasive malignancy. GNAS mutations were detected in polytypic PB-IPMNs (6/19; 32%), but there were no GNAS mutations in monotypic cases. The recurrence-free survival of patients with monotypic PB-IPMN or PDAC was similar and significantly worse than that of patients with polytypic PB-IPMN. In conclusion, some cases of monotypic PB-IPMNs lacked the classic characteristics of IPMNs and shared features with PDACs, raising the possibility that these cases may be better classified as a papillary variant of PDACs rather than IPMNs.

    2019年09月, Human pathology, 91, 26 - 35, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • 直腸静脈瘤に対して上直腸静脈直接穿刺法で塞栓術を行った1例

    元津 倫幸, 岡田 卓也, 小出 裕, 佐々木 康二, Hamada M.A.S., 堀之内 宏樹, 谷 龍一郎, 上嶋 英介, 祖父江 慶太郎, 山口 雅人, 杉本 幸司, 村上 卓道

    (一社)日本インターベンショナルラジオロジー学会, 2019年09月, 日本インターベンショナルラジオロジー学会雑誌, 34 (1), 79 - 79, 日本語

    [査読有り]

  • Yoshiko Ueno, Mitsuru Takeuchi, Tsutomu Tamada, Keitaro Sofue, Satoru Takahashi, Yuki Kamishima, Nobuyuki Hinata, Kenichi Harada, Masato Fujisawa, Takamichi Murakami

    A Vesical Imaging-Reporting and Data System (VI-RADS) based on multiparametric magnetic resonance imaging (mp-MRI) was developed to provide accurate information for the diagnosis of muscle-invasive bladder cancers (MIBCs). In this study we evaluated the interobserver agreement and diagnostic performance of VI-RADS. We retrospectively evaluated data for 74 consecutive patients with bladder cancer who had undergone mp-MRI before transurethral resection in a single institution from January 2010 to August 2018. Five readers assessed the probability of the presence of MIBC using VI-RADS scores. The interobserver agreement was assessed by measuring intraclass correlation coefficients (ICCs). Receiver operating characteristic (ROC) analysis was used to evaluate the MIBC diagnostic performance. The area under the ROC curve (AUC) was estimated for ordinal score assessments. Our study demonstrated that interobserver agreement was excellent among five readers (ICC 0.85, 95% confidence interval 0.80-0.89) and the diagnostic performance of VI-RADS was represented as a pooled AUC of 0.90 (95% confidence interval 0.87-0.93). PATIENT SUMMARY: We evaluated the interobserver agreement and diagnostic performance of a new scoring system based on magnetic resonance imaging called a Vesical Imaging-Reporting and Data System (VI-RADS) for muscle-invasive bladder cancer. Our results indicate that VI-RADS is suitable as a comprehensive tool for appropriate treatment planning for patients with bladder cancer.

    2019年07月, European urology, 76 (1), 54 - 56, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Takeshi Ezaki, Atsuhiro Masuda, Hideyuki Shiomi, Takashi Nakagawa, Keitaro Sofue, Hirochika Toyama, Yoh Zen, Yuzo Kodama

    © 2019 The Author(s). Published by S. Karger AG, Basel. A 79-year-old man was admitted with asymptomatic elevation of liver enzymes and tumor markers. Abdominal contrast-enhanced computed tomography demonstrated swelling of the pancreatic head, and additional blood test showed raised IgG4 levels. Histological examination by endoscopic ultrasonography (EUS)-guided fine needle aspiration for pancreatic head mass revealed storiform fibrosis and IgG4-positive plasma cell infiltration. We diagnosed this case as type 1 autoimmune pancreatitis (AIP). In addition, there was a cystic lesion in the pancreatic body apart from the pancreatic head mass. A mural nodule in the multilocular cyst was detected by EUS, and there was positive uptake of fluorodeoxyglucose in positron emission tomography/magnetic resonance imaging. The preoperative diagnosis of this cystic lesion was intraductal papillary mucinous carcinoma, and distal pancreatomy was performed. Histopathological findings showed various sizes of retention cysts caused by IgG4-positive plasma cell infiltration around the pancreatic branch ducts. The mural nodule was a fibrotic mass with diffuse infiltration of IgG4-positive cells. This cystic lesion mimicking malignant cystic neoplasm occurred in relation to AIP. This case provided important information helping to understand the mechanism of formation of mural nodules in multilocular cysts in patients with type 1 AIP.

    2019年05月01日, Case Reports in Gastroenterology, 13 (2), 265 - 270

    [査読有り]

    研究論文(学術雑誌)

  • Tomoyuki Gentsu, Takuya Okada, Masato Yamaguchi, Hiroki Horinouchi, Naoto Katayama, Eisuke Ueshima, Yutaka Koide, Keitaro Sofue, Yasuko Gotake, Yoshikatsu Nomura, Hiroshi Tanaka, Yutaka Okita, Koji Sugimoto, Takamichi Murakami

    PURPOSE: To evaluate the incidence of type II endoleak (EL-II) and aneurysm enlargement after endovascular aneurysm repair (EVAR) using the Endurant stent graft in patients with abdominal aortic aneurysm (AAA) with occluded inferior mesenteric artery (IMA). MATERIALS AND METHODS: Between 2012 and 2017, 103 patients who underwent EVAR using the Endurant stent graft for AAA with occluded IMA (50 patients with prophylactic embolized IMA and 53 with spontaneous occluded IMA) were retrospectively reviewed. The incidence of EL-II and aneurysm enlargement was evaluated. Predictive factors for persistent EL-II were evaluated based on patient characteristics, preprocedural anatomical characteristics, intraprocedural details, and postprocedural complications. RESULTS: Incidence rates of early EL-II and persistent EL-II were 6.8% (7/103 patients) and 4.9% (5/103 patients), respectively. Aneurysm enlargement was found in 10 patients (9.7%), including all 5 patients with persistent EL-II, 3 with de novo EL-II, and 2 with no EL-II. The rates of freedom from aneurysm enlargement at 1, 2, and 3 years were 98.7%, 97.0%, and 93.1% for the group without persistent EL-II, and 80.0%, 60.0%, and 20.0% for the group with persistent EL-II (p < 0.001), respectively. The maximum aneurysm diameter (odds ratio (OR), 1.16; 95% confidence interval (CI), 1.01-1.34; p = 0.0362) and the number of patent lumbar arteries (OR, 2.72; 95% CI, 1.07-6.90; p = 0.0357) were predictive of persistent EL-II. CONCLUSIONS: The incidence of EL-II after EVAR using the Endurant stent graft for AAA with occluded IMA was low, but most early EL-II persisted and resulted in aneurysm enlargement. Level of Evidence Level 4, Case Series.

    2019年04月, Cardiovascular and interventional radiology, 42 (4), 505 - 512, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Koji Maruyama, Keitaro Sofue, Takuya Okada, Yutaka Koide, Eisuke Ueshima, Genzo Iguchi, Ryuichiro Tani, Tomoyuki Gentsu, Hiroki Horinouchi, Koji Sasaki, Masato Yamaguchi, Koji Sugimoto, Takamichi Murakami

    PURPOSE: To evaluate the advantages of intraprocedural CT during adrenal venous sampling (AVS) to confirm accurate catheterization of the right adrenal vein (RAV). MATERIALS AND METHODS: This single-institution study included 106 patients (mean age 52.4 years; range 28-74 years) with primary aldosteronism who performed contrast-enhanced CT (CECT) before AVS following AVS between January 2011 and March 2018. After catheterization of the RAV under fluoroscopic guidance, unenhanced CT images were obtained to confirm catheter position on unified CT angiography system. Catheter repositioning was performed when the catheter was inaccurately positioned. Venography findings were classified into two groups: (1) presumably cannulated in the RAV (presumed RAV group) and (2) obscured visualization of the RAV because of collateral vessels (obscured RAV group). Success rates of AVS were compared using Fisher's exact test. RESULTS: The overall success of AVS was achieved in 104 patients (98.1%). Catheter was deviated into the IVC during intraprocedural CT in four patients. Fourteen patients (14.0%) required catheter repositioning by intraprocedural CT images, and accurate catheterization in the RAV was eventually accomplished. The success rate of AVS was significantly higher in the presumed RAV group (90.1% [73/81]) than that in the obscured RAV group (68.4% [13/19]) (p = 0.024). If intraprocedural CT was not acquired during AVS, the success rate of AVS would have been significantly lower (84.9% [90/106]) compared with that use of intraprocedural CT (98.1% [104/106]) (p < 0.001). CONCLUSIONS: Intraprocedural unenhanced CT by referring to the preprocedural CECT before AVS enables the confirmation of accurate catheterization of the RAV. LEVEL OF EVIDENCE: Level 4, case series.

    2019年04月, Cardiovascular and interventional radiology, 42 (4), 542 - 551, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Ryuichiro Tani, Keitaro Sofue, Koji Sugimoto, Naoto Katayama, Mostafa A S Hamada, Koji Maruyama, Hiroki Horinouchi, Tomoyuki Gentsu, Koji Sasaki, Eisuke Ueshima, Yutaka Koide, Takuya Okada, Masato Yamaguchi, Takamichi Murakami

    PURPOSE: To assess the safety and efficacy of transarterial embolization (TAE) and to evaluate the utility of contrast-enhanced computed tomography (CE-CT) for life-threatening spontaneous retroperitoneal hemorrhage (SRH). METHODS: Nineteen patients underwent TAE following CE-CT for life-threatening SRH. CE-CT and angiographic findings, technical successes, and clinical successes were evaluated. The diagnostic performance of CE-CT for the detection of active bleeding arteries was also assessed by two independent readers. RESULTS: Active extravasation of contrast material was accurately observed in 78.9‒84.2% of the patients on CE-CT. Angiograms revealed active extravasation in 37 arteries of 15 patients (78.9%), and 4 patients showed no sign of active bleeding. Sensitivity, positive predictive value, and accuracy rate of CE-CT for the detection of active bleeding vessels was 59.5%, 62.9‒71.0% and 55.6‒60.0% respectively. The successful embolization of 48 intended arteries was achieved in all the patients, including empirical TAE in four patients. Hemodynamic stabilization was achieved in 17 patients (89.5%) with a significant decrease in transfusion (p < 0.001). CONCLUSION: TAE is a technically safe and clinically effective treatment method for life-threatening SRH. CE-CT has moderate capability for accurate identification of active bleeding arteries. TAE including arteries that potentially distribute anatomic territory of the hematoma is essential.

    2019年04月, Japanese journal of radiology, 37 (4), 328 - 335, 英語, 国内誌

    [査読有り]

    研究論文(学術雑誌)

  • 祖父江 慶太郎, 上嶋 英介, 上野 嘉子, 岡田 卓也, 山口 雅人, 杉本 幸司, 鶴崎 正勝, 村上 卓道

    <文献概要>Point 1.肝細胞癌の診断において画像診断はきわめて重要な位置を占め,ダイナミックCT・MRIによる血流評価はその基本である.2.肝細胞特異性造影剤(Gd-EOB-DTPA)の臨床導入は,肝細胞癌の診断体系を変化させるほどのインパクトを与えている.

    (株)学研メディカル秀潤社, 2019年04月, 画像診断, 39 (6), 623 - 631, 日本語

    [査読有り]

    研究論文(学術雑誌)

  • 香川清澄, 根宜典行, 祖父江慶太郎, 村上卓道

    2019年04月, 臨床画像 - 特集:症候別画像診断プロトコル -, 35 (4), 180 - 181, 日本語

    [査読有り]

    研究論文(学術雑誌)

  • IVR手技施行に関する診療体制についての提言

    米虫 敦, 市田 隆雄, 井上 政則, 大内 泰文, 小野澤 志郎, 谷掛 雅人, 田村 全, 堀川 雅弘, 藪田 実, 谷川 昇, 曽根 美雪, 後藤 靖雄, 坂本 憲昭, 塩山 靖和, 祖父江 慶太郎, 中島 康雄, 野口 智幸, 橋本 政幸, 保本 卓, 矢田 晋作, 穴井 洋, 林 信成, 日本IVR学会, IVR手技施行に関する診療体制についての提言作成委員会, 日本IVR学会ガイドライン委員会, IVR手技施行に関する診療体制についての提言評価委員会

    (一社)日本インターベンショナルラジオロジー学会, 2019年04月, 日本インターベンショナルラジオロジー学会雑誌, 33 (4), 445 - 460, 日本語

  • 骨盤骨折に対するIVR施行医のためのガイドライン2017

    塩山 靖和, 江頭 秀哲, 曽根 美雪, 野口 智幸, 比気 貞治, 松本 純一, 村上 佳菜子, 谷川 昇, 大内 泰文, 米虫 敦, 坂本 憲昭, 祖父江 慶太郎, 中島 康雄, 橋本 政幸, 保本 卓, 矢田 晋作, 新藤 正輝, 船曳 知弘, 日本IVR学会, 骨盤骨折に対するIVR施行医のためのガイドライン2017ガイドライン作成委員会, 骨盤骨折に対するIVR施行医のためのガイドライン委員会, 日本IVR学会ガイドライン委員会, 骨盤骨折に対するIVR施行医のためのガイドライン2017ガイドライン評価委員

    (一社)日本インターベンショナルラジオロジー学会, 2019年04月, 日本インターベンショナルラジオロジー学会雑誌, 33 (4), 461 - 471, 日本語

  • Masayuki Akita, Keitaro Sofue, Kohei Fujikura, Kyoko Otani, Tomoo Itoh, Tetsuo Ajiki, Takumi Fukumoto, Yoh Zen

    BACKGROUND: Growing evidence has suggested that intrahepatic cholangiocarcinoma (iCCA) can be classified into small- and large-duct types. The present study aimed to elucidate how large-duct iCCA is similar and dissimilar to perihilar cholangiocarcinoma (pCCA). METHODS: The study cohort consisted of iCCA (n = 58) and pCCA (n = 44). After iCCA tumors were separated into small- (n = 36) and large-duct (n = 22) types based on our histologic criteria, genetic statuses of the three types of neoplasms were compared. Locations of iCCA were plotted on a three-dimensional image and their distances from the portal bifurcation were measured. RESULTS: Large-duct iCCA was distinct from small-duct iCCA in terms of frequency of bile duct reconstruction required, perineural infiltration, and survival, with these features more similar to pCCA. Large-duct iCCA and pCCA more frequently had the loss of SMAD4 expression and MDM2 amplifications than small-duct iCCA, whereas the loss of BAP1 expression and IDH1 mutations were mostly restricted to small-duct iCCA. From imaging analysis, most tumors of large-duct iCCA were present around the second branches of the portal vein. CONCLUSION: Large-duct type iCCA shared the molecular features with pCCA, and it may be reasonable to expand the definition of pCCA to include cancers originating from the second bile duct branches.

    2019年02月, HPB : the official journal of the International Hepato Pancreato Biliary Association, 21 (2), 226 - 234, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Tsurusaki M, Oda T, Sofue K, Numoto I, Yagyu Y, Kashiwagi N, Murakami T

    OBJECTIVE:: To devise a simple new technique wherein absolute ethanol is injected via a sheath under proximal balloon occlusion of the right portal vein using a single-balloon catheter and to examine its feasibility and safety for ipsilateral portal vein embolization (PVE). METHODS:: Between 2010 and 2016, PVE was performed in 19 patients prior to undergoing extended right hepatectomy. PVE was performed via a percutaneous transhepatic ipsilateral approach, the right portal branch was embolized under ultrasound guidance, and a balloon catheter was placed in the proximal site of the main right portal branch. Absolute ethanol was injected through a sheath under proximal balloon occlusion of the right portal vein using a double-lumen catheter. We evaluated its technical success and complications following PVE and changes in liver enzyme levels. Furthermore, we calculated changes in future liver remnant (FLR) and FLR/total functional liver volume (TFLV) ratio and assessed complications following hepatic resection. RESULTS:: PVE was successfully performed in all patients. Mean FLR and FLR/TFLV significantly increased following PVE (p < 0.01). The change in the FLR and FLR/TFLV ratio was 39.6 ± 16.2%. One patient (6.5%) developed procedure-related complications following PVE (perihepatic hematoma). CONCLUSION:: The new technique for ipsilateral right PVE is safe, effective, and convenient. ADVANCES IN KNOWLEDGE:: This is the first study to investigate the efficacy of injecting ethanol via a sheath under proximal balloon occlusion of the right portal vein using a single-balloon catheter.

    2018年12月, The British journal of radiology, 91 (1092), 20180124 - 20180124, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • 祖父江慶太郎, 山口雅人, 杉本幸司, 村上卓道

    2018年12月, 臨床放射線, 63 (12), 122 - 125

    [査読有り]

  • Sofue K, Itoh T, Takahashi S, Schmidt B, Shimada R, Negi N, Sugimura K, Murakami T

    OBJECTIVE: The aim of this study was to assess the ability of third-generation dual-source dual-energy computed tomography to quantify cisplatin concentration using a 3-material decomposition algorithm in an experimental phantom. MATERIALS AND METHODS: Fifteen agarose-based phantoms containing various concentrations of iodine (0, 1.0, 2.0 mg I/mL) and cisplatin (0, 0.5, 1.0, 2.0, 3.0 mg Pt/mL) were scanned using third-generation dual-source dual-energy computed tomography at 80 kV and 150 kV with tin prefiltration. A cisplatin map was generated using the cisplatin-specific 3-material decomposition algorithm to differentiate cisplatin from iodine and agar. The computed tomography (CT) values at 80 kV, 150 kV, mixed 120 kV, and the cisplatin map were measured. Interobserver variabilities for the CT measurements on the cisplatin map were assessed using interclass correlation coefficients. Correlation between the CT values and titrated cisplatin concentrations was correlated using Spearman rank correlation analysis. To assess the influence of iodine, linear regression lines for the CT values on the cisplatin map and titrated cisplatin concentrations were compared using an analysis of covariance. RESULTS: Interobserver agreement revealed almost perfect agreements (interclass correlation coefficients = 0.941-0.995). Significant and excellent positive correlations were observed between the CT values on the cisplatin map and titrated cisplatin concentrations (ρ = 0.980, P < 0.001 for all). The cisplatin map could identify the lowest cisplatin concentration of 0.5 mg Pt/mL in the presence of iodine. The iodine concentration had no significant effect on the CT measurements on the cisplatin map (P = 0.297, adjusted R = 0.993). CONCLUSIONS: The cisplatin map generated from the 3-material decomposition algorithm allows quantification of a cisplatin concentration in an experimental phantom, independent of co-present iodine.

    2018年11月, Invest Radiol, 53 (11), 673 - 680, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Sofue K, Tsurusaki M, Mileto A, Hyodo T, Sasaki K, Nishi T, Chikugo T, Yada N, Kudo M, Sugimura K, Murakami T

    AIM: To investigate whether iodine density measurements from contrast-enhanced dual-energy computed tomography (CT) data can non-invasively stage liver fibrosis. METHODS: This single-center, prospective study was approved by our IRB with written informed consent. Forty-seven consecutive patients (26 men and 21 women; mean age, 63.1 years) with chronic liver disease underwent contrast-enhanced dual-energy CT of the liver (non-contrast, arterial, portal venous, and equilibrium phase images), followed by liver biopsy. Iodine density of liver and aorta were obtained by two independent observers. Iodine uptake of the liver (Δ Liver), representing the difference in iodine density between equilibrium phase and non-contrast images, was calculated and normalized by aorta (Δ Liver/Aorta). We accounted for contrast agent distribution volume by using hematocrit level. Accuracy of iodine density measurements for staging liver fibrosis was assessed by using receiver operating characteristic (ROC) curves. Multivariate linear regression analysis was used to assess the impact of independent variables (liver fibrosis stage and patient-related confounders) on iodine uptake. RESULTS: The Δ Liver/Aorta significantly increased and moderately correlated with METAVIR liver fibrosis stage (ρ = 0.645, P < 0.001). Areas under the ROC curve ranged from 0.795 to 0.855 for discriminating each liver fibrosis score (≥F1-F4). METAVIR fibrosis stage was the most significant independent factor associated with Δ Liver (P = 0.005) and Δ Liver/Aorta (P < 0.001). CONCLUSION: Hepatic extracellular volume fraction with contrast-enhanced dual-energy CT can non-invasively stage liver fibrosis in chronic liver diseases. This technique could prove useful for monitoring disease progression and treatment response, potentially reducing the need for liver biopsy.

    2018年11月, Hepatol Res, 48 (12), 1008 - 1019, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Kanda T, Wakabayashi Y, Zeng F, Ueno Y, Sofue K, Maeda T, Nogami M, Murakami T

    Radiation therapy is a useful treatment for tumors and vascular malformations of the central nervous system. Radiation therapy is associated with complications, including leukoencephalopathy, radiation necrosis, vasculopathy, and optic neuropathy. Secondary tumors are also often seen long after radiation therapy. Secondary tumors are often benign tumors, such as hemangiomas and meningiomas, but sometimes malignant gliomas and soft tissue sarcomas emerge. We review the imaging findings of complications that may occur after brain radiation therapy.

    2018年09月, Japanese journal of radiology, 36 (9), 519 - 527, 英語, 国内誌

    [査読有り]

    研究論文(学術雑誌)

  • Yoshiko R. Ueno, Tsutomu Tamada, Satoru Takahashi, Utaru Tanaka, Keitaro Sofue, Tomonori Kanda, Munenobu Nogami, Yoshiharu Ohno, Nobuyuki Hinata, Masato Fujisawa, Takamichi Murakami

    Computed diffusion-weighted MRI is a recently proposed post-processing technique that produces b-value images from diffusion-weighted imaging (DWI), acquired using at least two different b-values. This article presents an argument for computed DWI for prostate cancer by viewing four aspects of DWI: fundamentals, image quality and diagnostic performance, computing procedures, and future uses.

    KOREAN RADIOLOGICAL SOC, 2018年09月, KOREAN JOURNAL OF RADIOLOGY, 19 (5), 832 - 837, 英語

    [査読有り]

  • Tsurusaki M, Oda T, Sofue K, Numoto I, Yagyu Y, Kashiwagi N, Murakami T

    2018年09月, Br J Radiol, ePub, 英語

    [査読有り]

    研究論文(学術雑誌)

  • 産科危機的出血に対するIVR施行医のためのガイドライン2017 2012の部分改訂

    塩山 靖和, 曽根 美雪, 久保 隆彦, 深澤 一雄, 池田 宏明, 比気 貞治, 稲村 健介, 三須 陽介, 谷川 昇, 大内 泰文, 米虫 敦, 坂本 憲昭, 祖父江 慶太郎, 中島 康雄, 野口 智幸, 橋本 政幸, 保本 卓, 矢田 晋作, 大浦 訓章, 金山 尚裕, 川端 正清, 塚原 優己, 松田 秀雄, 蓮尾 金博, 日本IVR学会, 産科危機的出血に対するIVR施行医のためのガイドライン2017ガイドライン作成委員会, 産科危機的出血に対するIVRのガイドライン改訂委員会, 日本IVR学会ガイドライン委員会, 産科危機的出血に対するIVRのガイドライン2012ガイドライン評価委員会

    (一社)日本インターベンショナルラジオロジー学会, 2018年08月, IVR: Interventional Radiology, 33 (2), 165 - 194, 日本語

  • Kawanaka Y, Kitajima K Dr, Yamamoto S, Nakanishi Y, Yamada Y, Hashimoto T, Suzuki T, Go S, Kanematsu A, Nojima M, Sofue K, Trsurusaki M, Tamaki Y, Yoshida R, Yamakado K

    We aimed to compare 11C-choline positron emission tomography/computed tomography (PET/CT) with conventional imaging, including pelvic magnetic resonance imaging (MRI), contrast-enhanced chest, abdomen, and pelvic computed tomography (CT), and bone scintigraphy, for prostate cancer restaging. Thirty patients (median prostate-specific antigen [PSA: 11.8 ng/mL]) with suspected recurrent prostate cancer following definitive treatment underwent 11C-choline PET/CT and conventional imaging, including pelvic MRI, contrast-enhanced chest, abdomen, and pelvic CT, and bone scintigraphy. The results were compared with regard to patient- and lesion-based diagnostic performance for local recurrence, and for lymph node and bony metastases using receiver operating characteristic (ROC) analysis and McNemar's test. Documented local recurrence and node and bony metastases were present in 11 (36.7%), 10 (33.3%), and 17 (56.7%) cases, respectively, of the enrolled patients. Patient-based sensitivity / specificity / accuracy / area under the ROC curve for 11C-choline-PET/CT for diagnosing local recurrence were 90.9% / 94.7% / 93.3% / 0.975 and for conventional imaging were 90.9% / 100% / 96.7% / 1.0. Those who underwent 11C-choline-PET/CT for node metastasis were 90.0% / 95.0% / 93.3% / 0.925 and for conventional imaging were 70.0% / 95.0% / 86.7% / 0.905. Those who underwent 11C-choline-PET/CT for bone metastasis were 94.1% / 92.3% / 93.3% / 0.991 and who underwent conventional imaging were 94.1% / 84.6% / 90.0% / 0.982. No significant differences were observed among them. The lesion-based detection rate of 11C-choline PET/CT for local recurrences and node and bone metastases as compared to conventional imaging was 92.9% (13/14) vs. 92.9% (13/14); 87.1% (27/31) vs. 54.8% (17/31); and 96.9% (219/226) vs. 90.3% (204/226) respectively, with significant differences noted for detection of node and bone lesions (p=0.0044 and p=0.00030, respectively). 11C-choline-PET/CT is more accurate in the detection of recurrent prostate cancer nodes and bony metastatic lesions compared to conventional imaging and has the advantage of restaging the disease in a single step.

    2018年07月, Cureus, 10 (7), e2966, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Kanda T, Wakabayashi Y, Zeng F, Ueno Y, Sofue K, Maeda T, Nogami M, Murakami T

    2018年07月, Jpn J Radiol, 36 (9), 519 - 527, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Eisuke Ueshima, Koji Sugimoto, Takuya Okada, Naoto Katayama, Yutaka Koide, Keitaro Sofue, Mayumi Morizane, Kenji Tanimura, Masashi Deguchi, Masato Yamaguchi

    PURPOSE: To justify a classification system for angiographic images of uterine artery embolization (UAE) for postpartum hemorrhage (PPH) and identify new risk factors associated with failed embolization. MATERIALS AND METHODS: A retrospective analysis of 63 consecutive patients who underwent UAE for severe PPH was performed. Uterine artery angiography (UA) before embolization was classified into two types: type 1 was defined as complete staining and type 2 was defined as partial staining of the uterine arteries. The clinical outcome, UA classification, and other possible factors previously reported were evaluated. Univariate and multivariate analyses were performed to determine the factors related to clinical outcomes. RESULTS: Sixty-three patients were enrolled (type 1, 22; type 2, 41). The clinical success rates of the primary UAE session were 90.9% (20/22) for type 1 and 61.0% (25/41) for type 2 (p = 0.018). Univariate and multivariate analyses demonstrated that the only UA classification was significantly associated with primary UAE failure (p = 0.033). CONCLUSIONS: The UA classification is an independent predictive factor of the clinical success rate of the primary UAE session for PPH; thus, it is an intuitive and optimal predictor for interventional radiologists to decide whether additional therapy is necessary.

    2018年06月, Japanese journal of radiology, 36 (6), 394 - 400, 英語, 国内誌

    [査読有り]

    研究論文(学術雑誌)

  • Takuya Ikegawa, Atsuhiro Masuda, Arata Sakai, Hirochika Toyama, Yoh Zen, Keitaro Sofue, Takashi Nakagawa, Hideyuki Shiomi, Mamoru Takenaka, Takashi Kobayashi, Masaru Yoshida, Yoshifumi Arisaka, Yoshihiro Okabe, Hiromu Kutsumi, Takumi Fukumoto, Takeshi Azuma

    OBJECTIVES: The present study was conducted in order to elucidate the relationship between the number of cyst-existing regions and incidence of pancreatic ductal adenocarcinoma (PDAC) concomitant with intraductal papillary mucinous neoplasm (IPMN), which currently remains unclear. METHODS: Subjects comprised 141 patients undergoing resection for IPMN (Non-invasive IPMN (IPMN with low-to high-grade dysplasia): N = 94, invasive IPMN: N = 31, and PDAC concomitant with IPMN: N = 16) between November 2000 and February 2017. A logistic regression analysis was performed to assess the relationship between the number of cyst-existing regions (one region/two or more regions) and incidence of PDAC concomitant with IPMN, adjusted by clinical characteristics. Cyst-existing regions were defined by the number of anatomical parts of the pancreas: the head/body/tail of the pancreas. RESULTS: Multiple cyst-existing regions (two or more regions) correlated with the incidence of PDAC concomitant with IPMN (PDAC concomitant with IPMN in one region vs. two or more regions: 3/66 vs. 13/75, multivariable odds ratio [OR] = 4.11, 95% confidence interval [CI] = 1.22 to 18.8, P = 0.02). In contrast, multiple cyst-existing regions did not correlate with the incidence of IPMN (invasive IPMN in one region vs. two or more regions: 13/66 vs. 18/75, OR = 1.19, 95% CI = 0.52 to 2.76, P = 0.67). CONCLUSIONS: Multifocal cysts correlated with the incidence of PDAC concomitant with IPMN, and may be a high-risk factor for PDAC concomitant with IPMN.

    Elsevier {BV}, 2018年06月, Pancreatology, 18 (4), 399 - 406, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • 鶴崎正勝, 祖父江慶太郎, 村上卓道

    2018年05月, 臨床消化器内科, 33 (6), 599 - 602, 日本語

    [査読有り]

  • Ikegawa T, Masuda A, Sakai A, Toyama H, Zen Y, Sofue K, Nakagawa T, Shiomi H, Takenaka M, Kobayashi T, Yoshida M, Arisaka Y, Okabe Y, Kutsumi H, Fukumoto T, Azuma T

    2018年04月, Pancreatology, 18 (4), 399 - 406, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Ueshima E, Sugimoto K, Okada T, Katayama N, Koide Y, Sofue K, Morizane M, Tanimura K, Deguchi M, Yamaguchi M

    2018年04月, Jpn J Radiol, 36 (6), 394 - 400, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Takuya Mizumoto, Hirochika Toyama, Sadaki Asari, Sachio Terai, Hideyo Mukubo, Hironori Yamashita, Sachiyo Shirakawa, Yoshihide Nanno, Yuki Ueda, Keitaro Sofue, Motofumi Tanaka, Masahiro Kido, Tetsuo Ajiki, Takumi Fukumoto

    BACKGROUND: The prognostic impact of pancreatic ductal adenocarcinoma (PDAC) invasion to the splenic vessel is controversial. OBJECTIVE: The aim of this study was to assess the clinical value of pathological and radiological splenic vessel invasion in PDACs of the body and tail. METHODS: Medical records of patients with resectable PDAC of the body and tail who underwent distal pancreatectomy between 2003 and 2016 at the Kobe University Hospital were retrospectively analyzed. RESULTS: Overall, 68 patients (29 female and 39 male patients) were enrolled. Pathologically determined splenic vein invasion (p-SV) and splenic artery invasion (p-SA) were identified in 21 (30.9%) and 5 (7.4%) patients, respectively. The p-SV (but not p-SA) was an independent prognostic factor in multivariate analysis (p = 0.009). On analysis of recurrence patterns, patients with PDAC positive for p-SV were at a higher risk for liver metastasis (p = 0.022); however, the associations were not significant for other recurrence patterns. Liver metastasis occurred earlier in patients who were positive for p-SV (p = 0.015). Preoperative computed tomography effectively diagnosed pathological vessel invasion (SV: sensitivity, 95.2%, specificity, 72.3%; SA: sensitivity, 100%, specificity, 84.1%). Radiological SV invasion remained significant in multivariate analysis regarding postoperative survival (p = 0.007), and was also associated with early liver metastases (p = 0.008). CONCLUSIONS: Pathological/radiological SV invasion were independent adverse prognostic factors associated with early liver metastasis in patients with PDAC of the body/tail. Assessment of these findings may be useful in determining optimal therapeutic options in these patients.

    2018年03月, Annals of surgical oncology, 25 (3), 638 - 646, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • KahokehrAA, SelphJP, BelsanteMJ, BashirM, SofueK, TauschTJ, BrandTC, LloydJC, GoldsmithZ, WalterJR, PetersonAC

    OBJECTIVE: To compare the length of the membranous (functional) urethra in male patients who underwent the male transobturator sling (TOS) for postradical prostatectomy urinary incontinence (PPI). The TOS is in established use for treatment of PPI; however, the precise mechanism of action is unknown. MATERIALS AND METHODS: This is a prospective case-controlled study on men undergoing male TOS surgery from 2008 to 2014. The comparison arm included patients without incontinence after radical prostatectomy. All participants underwent dynamic magnetic resonance imaging (MRI) at baseline and this was repeated after TOS placement for those who underwent the procedure. Three standardized points were measured using MRI and compared in both groups in addition to clinical measures. RESULTS: Thirty-nine patients were enrolled and 31 patients completed the protocols. The controls (N = 14) had a longer vesicourethral anastomosis to urethra measured at the penile bulb (functional urethral length) distance compared to the pre-TOS group at rest (1.92 cm controls vs 1.27 cm pre-TOS, P = .0018) and at Valsalva (2.13 cm controls vs 1.72 cm pre-TOS, P = .0371). Placement of the sling (N = 17) increased the functional urethral length distance at rest (1.92 cm control vs 1.53 cm post-TOS, P = .09) and at Valsalva (1.94 cm post-TOS vs 2.13 cm control, P = .61), so that the difference was no longer statistically significant. CONCLUSION: We identified that one possible mechanism in improvement in stress urinary incontinence post-TOS placement is the lengthening of the vesicourethral anastomosis to bulbar-urethra distance. This is the first such study utilizing dynamics MRI in post prostatectomy controls, incontinent pre-TOS, and post-TOS to assess and show these findings.

    2018年03月, Urology, 116, 185 - 192, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • IVR後の画像診断 Ch. 5 金属コイルを用いた動脈塞栓術後の画像診断

    岡田卓也, 曽宮雄一郎, 香川清澄, 前林知樹, Hamada M.A, S, 佐々木康二, 元津倫幸, 谷 龍一郎, 上嶋英介, 小出 裕, 祖父江慶太郎, 山口雅人, 杉本幸司, 村上卓道

    2018年02月, IVR会誌, 33 (2), 137 - 143, 日本語

    [査読有り]

    研究論文(学術雑誌)

  • II. 肝癌の診断: ダイナミックCT・MRI

    祖父江慶太郎, 鶴崎正勝, 村上卓道

    2018年02月, 日本臨床, 76 (2), 211 - 217, 日本語

    [査読有り]

  • Yosuke Yagi, Atsuhiro Masuda, Yoh Zen, Hideyuki Shiomi, Hirochika Toyama, Keitaro Sofue, Mamoru Takenaka, Takashi Kobayashi, Takashi Nakagawa, Kodai Yamanaka, Takuya Ikegawa, Namiko Hoshi, Masaru Yoshida, Yoshifumi Arisaka, Yoshihiro Okabe, Hiromu Kutsumi, Takumi Fukumoto, Yonson Ku, Takeshi Azuma

    BACKGROUND: Inflammation-induced carcinogenesis in pancreatic ductal adenocarcinoma (PDAC) has been reported; however, its involvement in PDAC with intraductal papillary mucinous neoplasm (IPMN) remains unclear. We herein investigated the relationship between pancreatic atrophy and inflammation and the incidence of PDAC concomitant with IPMN. METHODS: This study included 178 consecutive patients who underwent surgical resection for PDAC with IPMN (N = 21) and IPMN (N = 157) between April 2001 and October 2016. A multivariable logistic regression analysis was conducted to assess the relationship between pancreatic inflammation and atrophy and the incidence of PDAC concomitant with IPMN, with adjustments for clinical characteristics and imaging features. Pathological pancreatic inflammation and atrophy were evaluated in resected specimens. RESULTS: High degrees of pancreatic inflammation and atrophy were not associated with the incidence of PDAC with IPMN (multivariable odds ratio [OR] = 0.5, 95% confidence interval [CI] = 0.07 to 3.33, P = .52, adjusted by clinical characteristics, OR = 0.9, 95% CI = 0.10 to 5.86, P = .91, adjusted by imaging studies; OR = 0.2, 95% CI = 0.009 to 1.31, P = .10, adjusted by clinical characteristics, OR = 0.2, 95% CI = 0.01 to 1.43, P = .12, adjusted by imaging studies, respectively). CONCLUSIONS: Pancreatic inflammation and atrophy were not associated with pancreatic cancer concomitant with IPMN.

    Elsevier {BV}, 2018年01月, Pancreatology, 18 (1), 54 - 60, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Utaru Tanaka, Yoshiko Ueno, Yukiko Morinaga, Hideaki Miyake, Katsusuke Kyotani, Yu Ueda, Kazuhiro Kitajima, Keitaro Sofue, Yuko Suenaga, Kazuro Sugimura, Satoru Takahashi

    To investigate the impact of three-dimensional (3D) T2-weighted turbo spin-echo imaging (TSE-T2WI) with tissue-specific variable refocusing flip angle (TS-VRFA) on image quality and prostate cancer (PCa) detection and extraprostatic extension (EPE) evaluation compared to 2D TSE-T2WI and conventional 3D TSE-T2WI with volume isotropic TSE acquisition (VISTA). Image data sets of 40 patients who underwent 3-T MRI before prostatectomy, including multiplane 2D T2WI, 3D T2WI with TS-VRFA and VISTA, and diffusion-weighted images were independently evaluated by two radiologists. The detectability of PCa and EPE of each sequence was assessed using areas by the receiver operating characteristic curve (AUC) analysis. Image quality measures and contrast ratios (CR) between cancerous lesions and non-cancerous regions for each T2WI were also evaluated. Overall image quality of TS-VRFA was better than that of VISTA and equivalent to 2D. The highest CR was obtained with TS-VRFA (P < 0.05). For both readers, no significances were observed in detectability for PCa detection between three sequences (P > 0.05). For both readers, there were no significant differences in AUC for EPE evaluation between three sequences (P > 0.05). 3D T2 WI using TS-VRFA could potentially replace multiplane 2D T2 WI for prostate cancer diagnosis with better image quality than VISTA.

    SPRINGER, 2017年12月, JAPANESE JOURNAL OF RADIOLOGY, 35 (12), 707 - 717, 英語, 国内誌

    [査読有り]

    研究論文(学術雑誌)

  • Takuya Mizumoto, Tadahiro Goto, Hirochika Toyama, Keitaro Sofue, Sadaki Asari, Sachio Terai, Motofumi Tanaka, Masahiro Kido, Tetsuo Ajiki, Takumi Fukumoto, Yonson Ku

    BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) often infiltrates to the adjacent major vasculatures; however, direct invasion of PDAC to the inferior vena cava (IVC) is uncommon. CASE PRESENTATION: We report our experience with three cases of PDAC directly invading the IVC wall. All three patients underwent pancreatoduodenectomy along with wedge resection of the IVC wall without severe postoperative complications. Histopathological studies revealed tumor infiltration to the adventitia of the IVC. All patients achieved negative surgical margins. One patient was still alive 26 months after surgery without tumor recurrence. Two patients experienced recurrence; one patient experienced liver metastasis but was still alive and in a stable condition without further tumor progression 12 months after surgery. Another patient experienced multiple liver metastasis 10 months after surgery and died 26 months after surgery. CONCLUSIONS: Pancreatoduodenectomy along with wedge resection of the IVC wall for patients with PDAC directly invading the adventitia of the IVC can be performed safely. Further accumulation of cases is needed to elucidate the prognostic impact of IVC invasion.

    2017年12月, Surgical case reports, 3 (1), 72 - 72, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Takuya Mizumoto, Hirochika Toyama, Sachio Terai, Hideyo Mukubou, Hironori Yamashita, Sachiyo Shirakawa, Yoshihide Nanno, Keitaro Sofue, Masahiro Kido, Tetsuo Ajiki, Takumi Fukumoto

    Background: Iso- or hypo-attenuating areas in the arterial phase on contrast-enhanced computed tomography (CE-CT) have been reported to be negative prognostic features in pancreatic neuroendocrine tumors (PNETs). Given that the optimal indication for lymph node dissection in patients with PNET remains unclear, we sought to utilize enhancement characteristics on CE-CT as a preoperative predictor of regional lymph node metastasis in PNETs. Methods: The medical records of patients with well-differentiated PNETs who underwent pancreatectomy along with lymphadenectomy were retrospectively analyzed. We divided PNETs into two groups based on the extent of attenuation in the late arterial phase on CE-CT imaging. PNETs that showed hyper-attenuation over the entire area compared to the adjacent normal pancreas were categorized as hyper-PNETs. PNETs that contained both hyper and iso- or hypo-attenuation regions as well as those that showed only iso- or hypo-attenuation over the entire area were categorized as hetero/hypo-PNETs. Results: Forty-one patients with a median age of 64 years were enrolled, including 11 with hyper-PNETs and 30 with hetero/hypo-PNETs. Hetero/hypo-PNETs were significantly larger than hyper-PNETs (P = 0.022), and the former group more frequently comprised G2 tumors, according to the World Health Organization 2010 classification (P < 0.001). On univariate and multivariate analyses, hetero/hypo-PNETs were independently associated with regional lymph node metastasis. Conclusions: The presence of iso- or hypo-attenuating regions appears to be associated with regional lymph node metastasis in PNETs. Tumor enhancement characteristics should be assessed in patients with PNET so as not to miss those at high risk of lymph node metastasis. (C) 2017 IAP and EPC. Published by Elsevier B.V. All rights reserved.

    ELSEVIER SCIENCE BV, 2017年11月, PANCREATOLOGY, 17 (6), 956 - 961, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Kazuhiro Kitajima, Masatoyo Nakajo, Hayato Kaida, Ryogo Minamimoto, Kenji Hirata, Masakatsu Tsurusaki, Hiroshi Doi, Yoshiko Ueno, Keitaro Sofue, Yukihisa Tamaki, Koichiro Yamakado

    Positron emission tomography/computed tomography (PET/CT) integrated with 2-[18F]fluoro-2-deoxy-D-glucose (FDG) is a useful tool for acquisition of both glucose metabolism and anatomic imaging data, as only a single device and one diagnostic session is required, thus opening a new field in clinical oncologic imaging. FDG-PET/CT has been successfully used for initial staging, restaging, assessment of early treatment response, evaluation of metastatic disease response, and prognostication of intestinal cancer as well as various malignant tumors. We reviewed the current status and role of FDG-PET/CT for management of patients with esophageal cancer, gastric cancer, and colorectal cancer, with focus on both its usefulness and limitations.

    2017年11月, Nagoya journal of medical science, 79 (4), 527 - 543, 英語, 国内誌

    [査読有り]

    研究論文(学術雑誌)

  • Keitaro Sofue, Lauren M. B. Burke, Viragi Nilmini, Madavi Alagiyawanna, Andrew J. Muir, Kingshuk R. Choudhury, Tracy A. Jaffe, Richard C. Semelka, Mustafa R. Bashir

    Purpose: To identify demographic and imaging features in magnetic resonance imaging (MRI) that are associated with upgrade of Liver Imaging Reporting and Data System (LI-RADS) category 4 (LR-4) observations to category 5 (LR-5), and to assess their effects on risk of upgrade and time to upgrade. Materials and Methods: Institutional Review Board approval was obtained for this retrospective, dual-institution Health Insurance Portability and Accountability Act (HIPAA)-compliant study. Radiologists reviewed 1.5T and 3T MRI examinations for 181 LR-4 observations in 139 patients, as well as follow-up computed tomography (CT) and MRI examinations and treatment. A stepwise multivariate Cox proportional hazards model analysis was performed to identify predictive risk factors for upgrade to LR-5, including patient demographics and LI-RADS imaging features. Overall cumulative risk of upgrade was calculated by using the Kaplan-Meier method. The cumulative risks were compared in the presence/absence of significant predictive risk factors using the log-rank test. Results: The independent significant predictive risk factors in the 56 LR-4 observations that upgraded to LR-5 were mild-moderate T-2 hyperintensity (P < 0.001; hazard ratio = 1.84), growth (P < 0.001; hazard ratio = 3.71), and hepatitis C infection (P = 0.02; hazard ratio = 1.69). The overall 6-month cumulative risk of upgrade was 32.7%. The 6-month cumulative risk rate was significantly higher in the presence of T-2 hyperintensity (P = 0.03; 48.1% vs. 25.4%). Conclusion: For LR-4 observations, mild-moderate T-2 hyperintensity, threshold growth, and hepatitis C infection are associated with significantly higher risk of upgrade to LR-5. Although mild-moderate T-2 hyperintensity was the most useful risk factor for predicting upgrade, actual risk level was only mildly elevated, and the risk of upgrade associated with LR-4 observations is similar across subtypes.

    WILEY, 2017年09月, JOURNAL OF MAGNETIC RESONANCE IMAGING, 46 (3), 783 - 792, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Naoto Katayama, Koji Sugimoto, Takuya Okada, Takeshi Ueha, Yoshitada Sakai, Hideo Akiyoshi, Keiichiro Mie, Eisuke Ueshima, Keitaro Sofue, Yutaka Koide, Ryuichiro Tani, Tomoyuki Gentsu, Masato Yamaguchi

    The present study aimed to evaluate the efficacy of an intra-arterially infused carbon dioxide (CO2)-saturated solution in sensitizing the anticancer effect of cisplatin in a rabbit VX2 liver tumor model. Forty VX2 liver tumor-bearing Japanese white rabbits were randomly divided into four groups and infused via the proper hepatic artery with a saline solution (control group), CO2-saturated solution (CO2 group), cisplatin solution (cisplatin group), or CO2-saturated solution and cisplatin solution (combined group). The tumor volume (TV) and the relative tumor volume (RTV), RTV = (TV on day 3 or 7)/(TV on day 0) x 100, were calculated using contrast-enhanced computed tomography. Hypoxia-inducible factor-1α (HIF‑1α) and carbonic anhydrase IX (CA IX) staining were used to evaluate cellular hypoxia. Cleaved caspase-3 and cleaved caspase-9 were analyzed to assess tumor apoptosis. The mean RTV on days 3 and 7 were 202.6±23.7 and 429.2±94.8%, respectively, in the control group; 172.2±38.1 and 376.5±61.1% in the CO2 group; 156.1±15.1 and 269.6±45.2% in the cisplatin group; and 118.3±28.1 and 210.3±55.1% in the combined group. RTV was significantly lower in the CO2 group than in the control group (day 3; P<0.05), and in the combined group than in the cisplatin group (days 3 and 7; P<0.05). HIF-1α and CA IX suppression, and increased cleaved caspase-3 and cleaved caspase-9 expression, were detected in the CO2 and combined groups, compared with the other two groups. An intra-arterially infused CO2-saturated solution inhibits liver VX2 tumor growth and sensitizes the anticancer effect of cisplatin.

    2017年08月, International journal of oncology, 51 (2), 695 - 701, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Keitaro Sofue, Takeshi Yoshikawa, Yoshiharu Ohno, Noriyuki Negi, Hiroyasu Inokawa, Naoki Sugihara, Kazuro Sugimura

    To determine the value of a raw data-based metal artifact reduction (SEMAR) algorithm for image quality improvement in abdominal CT for patients with small metal implants. Fifty-eight patients with small metal implants (3-15 mm in size) who underwent treatment for hepatocellular carcinoma were imaged with CT. CT data were reconstructed by filtered back projection with and without SEMAR algorithm in axial and coronal planes. To evaluate metal artefact reduction, mean CT number (HU and SD) and artefact index (AI) values within the liver were calculated. Two readers independently evaluated image quality of the liver and pancreas and visualization of vasculature using a 5-point visual score. HU and AI values and image quality on images with and without SEMAR were compared using the paired Student's t-test and Wilcoxon signed rank test. Interobserver agreement was evaluated using linear-weighted kappa test. Mean HU and AI on images with SEMAR was significantly lower than those without SEMAR (P < 0.0001). Liver and pancreas image qualities and visualizations of vasculature were significantly improved on CT with SEMAR (P < 0.0001) with substantial or almost perfect agreement (0.62 <= kappa <= 0.83). SEMAR can improve image quality in abdominal CT in patients with small metal implants by reducing metallic artefacts. aEuro cent SEMAR algorithm significantly reduces metallic artefacts from small implants in abdominal CT. aEuro cent SEMAR can improve image quality of the liver in dynamic CECT. aEuro cent Confidence visualization of hepatic vascular anatomies can also be improved by SEMAR.

    SPRINGER, 2017年07月, EUROPEAN RADIOLOGY, 27 (7), 2978 - 2988, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Masafumi Toguchi, Masakatsu Tsurusaki, Norihisa Yada, Keitaro Sofue, Tomoko Hyodo, Minori Onoda, Isao Numoto, Mitsuru Matsuki, Izumi Imaoka, Masatoshi Kudo, Takamichi Murakami

    Purpose: To evaluate the quantitative measurement of liver stiffness (LS), compare the diagnostic performance of magnetic resonance elastography (MRE) and ultrasound-based transient elastography (TE), and evaluate two different MRE-based LS measurement methods. Methods: Between October 2013 and January 2015, 116 consecutive patients with chronic liver disease underwent MRE to measure LS (kilopascals; kPa). Of the 116 patients, 51 patients underwent both TE and liver biopsy, and the interval between the liver biopsy and both the MRE and TE was less than 90 days. MRE-derived LS values were measured on the anterior segment of the right lobe (single small round regions of interest per slice; srROIs) and whole right lobe of the liver (free hand region of interest; fhROI), and these values were correlated with pathological fibrosis grades and diagnostic performance. Results: Pathological fibrosis stage was significantly correlated with srROIs (r = 0.87, p < 0.001), fhROI (r = 0.80, p < 0.001), and TE (r = 0.73, p < 0.001). For detection of significant fibrosis (>= F2), advanced fibrosis (>= F3), and cirrhosis, the area under the curve (AUC) associated with the srROIs was largest, and there was a significant difference between srROIs and TE (0.93 vs. 0.82, p = 0.006), srROIs and fhROI (0.93 vs. 0.89, p = 0.04) for detection of >= F2. For advanced fibrosis and cirrhosis detection, AUCs were not significant (0.92-0.96). Conclusions: MRE and TE detected liver fibrosis with comparable accuracy. In particular, the srROIs method was effective for detecting of significant fibrosis.

    SPRINGER, 2017年06月, ABDOMINAL RADIOLOGY, 42 (6), 1659 - 1666, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Tatsuya Nishii, Yoshiaki Watanabe, Shinsuke Shimoyama, Atsushi K. Kono, Keitaro Sofue, Shumpei Mori, Satoru Takahashi, Kazuro Sugimura

    Objectives: To achieve the efficient usage of contrast material (CM) in high-pitch CT aortography, an appropriate duration of the CM injection is crucial. We used a modification of the double-level test bolus method for determination of proper injection duration with the aim of evaluating the image quality of tailored-duration CM injection compared with that of a fixed duration. Materials and Methods: The institutional review board approved retrospective review of 80 consecutive subjects who had undergone high-pitch 70-kVp CT aortography with a modified double-level test bolus method. The interval between peak enhancement at the aortic root and femoral artery was derived from the time/attenuation curves. A total of 40 subjects underwent CT aortography with individually set duration time from the results. The remaining subjects underwent CT aortography with a fixed-duration time. The density values at several parts of the aorta were assessed. The differences in image quality and CM amount used for each method were assessed by Welch test. Results: The injection duration was almost 50% shorter (median, 15 seconds; range, 11-25 seconds) when individually tailored. The mean CM amount was reduced by 50% (46.2-23.9 mL, P < 0.01). The range of mean CT attenuation throughout the aorta was not significantly different between the 2 methods (316-327 HU and 305-321 HU, P > 0.05, respectively). Conclusions: The modified double-level test bolus method in high-pitch CT aortography can significantly reduce the amount of CM without adversely affecting image quality.

    LIPPINCOTT WILLIAMS & WILKINS, 2017年05月, INVESTIGATIVE RADIOLOGY, 52 (5), 274 - 280, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Diego Hernando, Samir Sharma, Mounes Aliyari Ghasabeh, Bret Alvis, Sandeep Arora, Gavin Hamilton, Li Pan, Jean Shaffer, Keitaro Sofue, Nikolaus Szeverenyi, E. Brian Welch, Qing Yuan, Mustafa Bashir, Ihab Kamel, Mark Rice, Claude Sirlin, Takeshi Yokoo, Scott Reeder

    Purpose: To evaluate the accuracy and reproducibility of quantitative chemical shift-encoded (CSE) MRI to quantify proton-density fat-fraction (PDFF) in a fat-water phantom across sites, vendors, field strengths, and protocols. Methods: Six sites (Philips, Siemens, and GE Healthcare) participated in this study. A phantom containing multiple vials with various oil/water suspensions (PDFF: 0%-100%) was built, shipped to each site, and scanned at 1.5T and 3T using two CSE protocols per field strength. Confounder-corrected PDFF maps were reconstructed using a common algorithm. To assess accuracy, PDFF bias and linear regression with the known PDFF were calculated. To assess reproducibility, measurements were compared across sites, vendors, field strengths, and protocols using analysis of covariance (ANCOVA), Bland-Altman analysis, and the intraclass correlation coefficient (ICC). Results: PDFF measurements revealed an overall absolute bias (across sites, field strengths, and protocols) of 0.22% (95% confidence interval, 0.07%-0.38%) and R-2 > 0.995 relative to the known PDFF at each site, field strength, and protocol, with a slope between 0.96 and 1.02 and an intercept between -0.56% and 1.13%. ANCOVA did not reveal effects of field strength (P = 0.36) or protocol (P = 0.19). There was a significant effect of vendor (F = 25.13, P = 1.07 x 10(-10)) with a bias of -0.37% (Philips) and -1.22% (Siemens) relative to GE Healthcare. The overall ICC was 0.999. Conclusion: CSE-based fat quantification is accurate and reproducible across sites, vendors, field strengths, and protocols. (C) 2016 International Society for Magnetic Resonance in Medicine

    WILEY, 2017年04月, MAGNETIC RESONANCE IN MEDICINE, 77 (4), 1516 - 1524, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Nobuyuki Asato, Masakatsu Tsurusaki, Keitaro Sofue, Yoko Hieda, Takashi Katsube, Kazuhiro Kitajima, Takamichi Murakami

    Purpose To evaluate the diagnostic efficacy of gadoxetic acid-enhanced magnetic resonance imaging (EOB-MRI) vs. contrast-enhanced computed tomography (CE-CT) in the detection of liver metastasis in colorectal carcinoma patients. Materials and methods One-hundred fifty-eight consecutive patients with histopathologically confirmed colorectal carcinoma underwent EOB-MRI and CE-CT; 68 patients had 105 surgically confirmed liver metastases. Diagnostic analyses were performed according to sensitivity and positive predictive value (PPV) for liver metastasis detection in combined arterial- and hepatocyte-phase images vs. CE-CT by three readers blinded to clinical data. Diagnostic accuracy and sensitivity were evaluated using the alternative free-response receiver operating characteristic method. Results The overall sensitivity of EOB-MRI (91.4%) was significantly higher than that of CE-CT (80.9%, p < 0.001); the higher sensitivity of EOB-MRI was observed especially in smaller-sized lesions (73.3 vs. 56.0% for lesions <= 1 cm; 91.9 vs. 80.8% for lesions > 1 cm and <= 2 cm; 99.2 vs. 95.7% for lesions > 2 cm). EOB-MRI showed a significantly greater area under the receiver operating characteristic curve (Az value = 0.970) compared with CE-CT (Az value = 0.899, p < 0.01). Conclusion EOB-MRI provided higher detectability for liver metastases, especially for smaller-sized lesions, than CE-CT in patients with colorectal carcinoma.

    SPRINGER, 2017年04月, JAPANESE JOURNAL OF RADIOLOGY, 35 (4), 197 - 205, 英語, 国内誌

    [査読有り]

    研究論文(学術雑誌)

  • 血管塞栓術に用いるNBCAのガイドライン2012

    佐藤 洋造, 竹内 義人, 森下 博之, 濱口 真吾, 坂本 憲昭, 徳江 浩之, 米満 尚史, 村上 健司, 藤原 寛康, 祖父江 慶太郎

    (一社)日本インターベンショナルラジオロジー学会, 2017年04月, IVR: Interventional Radiology, 32 (Suppl.), 116 - 116, 日本語

    [査読有り]

  • Kodai Yamanaka, Atsuhiro Masuda, Hirochika Toyama, Hideyuki Shiomi, Yoh Zen, Keitaro Sofue, Mamoru Takenaka, Takashi Kobayashi, Arata Sakai, Yosuke Yagi, Takashi Nakagawa, Masaru Yoshida, Yoshifumi Arisaka, Yoshihiro Okabe, Hiromu Kutsumi, Takumi Fukumoto, Yonson Ku, Takeshi Azuma

    Elsevier {BV}, 2017年01月, Pancreatology, 17 (1), 123 - 129, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Nakagawa, T., Masuda, A., Toyama, H., Shiomi, H., Zen, Y., Sofue, K., Takenaka, M., Kobayashi, T., Yagi, Y., Yamanaka, K., Yoshida, M., Arisaka, Y., Okabe, Y., Kutsumi, H., Fukumoto, T., Ku, Y., Azuma, T.

    OBJECTIVES: The effect of smoking status on the incidence of pancreatic ductal adenocarcinoma (PDAC) concomitant with intraductal papillary mucinous neoplasm (IPMN) has not been clarified. This study investigated the association of smoking status with PDAC concomitant with IPMN. METHODS: The subjects were 124 consecutive patients undergoing resection of IPMNs (intraductal papillary mucinous adenoma (IPMA): N = 77, invasive IPMN: N = 31, and PDAC with IPMN: N = 16) between April 2008 and October 2015. The associations between smoking status (never/former/current smoker) or cumulative pack-years (0-19/20-39/≥40) and the incidence of PDAC concomitant with IPMN or invasive IPMN were evaluated. RESULTS: Current smoking, not former smoking, was associated with the incidence of PDAC concomitant with IPMN (PDAC with IPMN vs IPMN alone; P = 0.004, PDAC with IPMN vs IPMA; P = 0.004, PDAC with IPMN vs invasive IPMN; P = 0.04, respectively), but not that of invasive IPMN (invasive IPMN vs IPMA; P = 0.85). Cumulative pack-years were higher in patients who had PDAC concomitant with IPMN than in patients with invasive IPMN (P = 0.04). Cumulative pack-years were not associated with smoking status (current vs former). CONCLUSIONS: Current smoking, not former smoking, was associated with the incidence of PDAC concomitant with IPMN. Cessation of smoking may be recommended for patients with IPMN.

    2017年, Pancreas, 46 (4), 582 - 588, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Keitaro Sofue, Yoshito Takeuchi, Masakatsu Tsurusaki, Kentaro Shibamoto, Noriaki Sakamoto, Kazuhiro Kitajima, Miyuki Sone, Kazuro Sugimura, Yasuaki Arai

    Nutritional management is important throughout the treatment period for esophageal cancer patients. This study aimed to evaluate the feasibility of percutaneous radiologic gastrostomy (PRG) and to investigate whether PRG can be applied for patients with advanced esophageal cancer. In this study, 89 patients (74 men and 15 women) with advanced esophageal cancer underwent PRG using computed tomography and fluoroscopic guidance. These patients were unsuitable candidates for endoscopic intervention because of esophageal stricture. Primary placement of a mushroom-retained gastrostomy catheter was intended. The end points were technical success and complications after PRG as well as clinical outcomes and survival of the patients. These end points also were compared between the pre-chemoradiotherapy (pre-CRT) and post-CRT groups using the Chi square test, Fisher's exact test, and the Wilcoxon rank sum test. The survival rate was calculated using the Kaplan-Meier method and compared using the log-rank test. All the patients had a successful PRG. The mushroom-tip gastrostomy catheter was primarily inserted in 77 patients (86.5 %) and finally achieved for all the patients. Complications occurred for 14 patients (15.7 %) including Dindo-Clavien classification grade 3 (1 catheter dislodgement), grade 2 (2 gastric hemorrhages), and grade 1 (7 skin infections and 4 oozing hemorrhages) complications. During the follow-up period (median, 6 months), 60 patients (67.4 %) died, giving a 12-month survival rate of 37.7 %. Gastrostomy removal was more common in the pre-CRT group (P = 0.011). The pre-CRT group had higher survival rates than the post-CRT group (P = 0.021). Because PRG provided high technical success with limited complications, it can be used for patients with advanced esophageal cancer whose treatment plan involves multimodal therapy.

    SPRINGER, 2016年10月, ANNALS OF SURGICAL ONCOLOGY, 23 (11), 3623 - 3631, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Yosuke Yagi, Atsuhiro Masuda, Yoh Zen, Mamoru Takenaka, Hirochika Toyama, Keitaro Sofue, Hideyuki Shiomi, Takashi Kobayashi, Takashi Nakagawa, Koudai Yamanaka, Namiko Hoshi, Masaru Yoshida, Yoshifumi Arisaka, Yoshihiro Okabe, Hiromu Kutsumi, Takumi Fukumoto, Yonson Ku, Takeshi Azuma

    Elsevier {BV}, 2016年09月, Pancreatology, 16 (5), 893 - 899, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Lauren M. B. Burke, Keitaro Sofue, Madavi Alagiyawanna, Viragi Nilmini, Andrew J. Muir, Kingshuk R. Choudhury, Richard C. Semelka, Mustafa R. Bashir

    Purpose: The purpose of this study was to characterize the MR imaging features and outcomes of liver imaging reporting and data system (LI-RADS) category 4 (LR4) nodules, with an emphasis on upgrade to category 5 (LR5) and development of contraindications to curative therapy. Methods: Institutional review board approval was obtained for this retrospective, dual-institutional Health Insurance Portability and Accountability Act-compliant study. The requirement for informed consent was waived. Contrast-enhanced MRI studies performed on patients with cirrhosis were retrospectively assessed using LI-RADS 2014 by at least two readers. All nodules were individually evaluated to determine their major imaging features at diagnosis, and follow-up data were used to determine the associated imaging outcomes. Results: One hundred eighty-one untreated LR4 nodules in 139 patients had adequate imaging and follow-up for inclusion in the study. Most (61% [111/181]) of these demonstrated arterial phase hyperenhancement, washout, and diameter less than 20 mm. During the follow-up period (median 163 days), 31% (56/181) of the nodules upgraded to LR5, 40% (73/181) remained stable, and 29% (52/181) downgraded. Of the nodules that upgraded, 61% (34/56) increased their size category and 54% (30/56) developed newly visualized capsules. No LR4 nodules developed venous invasion, satellites nodules, or new intrahepatic or extrahepatic metastatic disease. 75% (42/56) of the nodules that upgraded to LR5 did so within 6 months. Conclusions: Approximately one-third of LR4 nodules upgrade to LR5, and the short-term risk of developing venous invasion or metastasis is very low.

    SPRINGER, 2016年09月, ABDOMINAL RADIOLOGY, 41 (9), 1758 - 1766, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Keitaro Sofue, Xiaodong Zhong, Marcel D. Nickel, Brian M. Dale, Mustafa R. Bashir

    Objective: To assess changes in liver proton density fat fraction (PDFF) and R-2* measurements in the presence of changes in tissue relaxation rates induced by administrating gadoxetic acid, using two different image reconstruction methods at 3T MRI. Methods: Forty-five patients were imaged at 3T with chemical-shift-based MRI sequences before and 20 min after administration of gadoxetic acid. Image reconstructions were performed using hybrid and complex methods to obtain PDFF and R-2* images. A single radiologist measured PDFF and R-2* values on precontrast and postcontrast images. Precontrast and postcontrast PDFF values were compared using intraclass correlation coefficient (ICC), linear regression, and Bland-Altman analysis. Changes in R-2* values from precontrast to postcontrast were correlated with relative liver enhancement (RLE) based on signal intensities on T-1-weighted images using Spearman's rank correlation. Results: PDFF values were similar between precontrast and postcontrast images (ICC = 0.99, linear regression slopes = 0.98, mean difference = -0.21 to -0.31%). PDFF measurements were stable between precontrast and postcontrast images. Changes in R-2* values were correlated with RLE (p < 0.001, r = 0.49-0.71). Conclusions: PDFF measurements from both image reconstruction methods are stable in the presence of changes in tissue relaxation rates after administering gadoxetic acid at 3T MRI. Changes in R-2* values correlate with established measures of gadoxetic acid uptake based on T-1-weighted images

    SPRINGER, 2016年08月, ABDOMINAL RADIOLOGY, 41 (8), 1555 - 1564, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Masakatsu Tsurusaki, Keitaro Sofue, Takamichi Murakami

    A variety of imaging techniques, including ultrasonography (US), multidetector computed tomography (MDCT), magnetic resonance imaging (MRI) and positron emission tomography combined with CT scan (PET/CT), are available for diagnosis and treatment planning in liver metastasis. Contrast-enhanced MDCT is a relatively non-invasive, widely available and standardized method for hepatic work-up. Gadoxetic acid (gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid; EOB Primovist (R)]) is a recently developed liver-specific hepatobiliary MR contrast agent that offers both dynamic imaging as well as liver-specific static hepatocyte imaging, referred to as the hepatobiliary phase. Following contrast injection, this technique reveals dynamic vascular phases (arterial, portal venous and delayed phases), in addition to the hepatobiliary phase upon uptake by functional hepatocytes. The overall sensitivity of gadoxetic acid-enhanced MRI was significantly higher than that of contrast-enhanced CT. Specifically, the higher sensitivity of gadoxetic acid-enhanced MRI was observed in lesions smaller than 1cm in diameter. Gadoxetic acid-enhanced MRI is considered an extremely useful tool for the diagnosis of liver metastases. Future studies will focus on diagnostic algorithms involving combinations of modalities such as MRI, MDCT and/or F-18-fluorodeoxyglucose PET/CT, which may impact the treatment plan for these patients.

    WILEY, 2016年08月, HEPATOLOGY RESEARCH, 46 (9), 853 - 861, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • 膵神経内分泌腫瘍 CTにおける造影パターンと臨床病理学的所見の相関

    水本 拓也, 祖父江 慶太郎, 外山 博近, 後藤 直大, 田中 基文, Asari Sadaki, 木戸 正浩, 味木 徹夫, 福本 巧, 具 英成

    (一社)日本消化器外科学会, 2016年07月, 日本消化器外科学会総会, 71回, P3 - 2, 日本語

    [査読有り]

  • Keitaro Sofue, Claude B. Sirlin, Brian C. Allen, Rendon C. Nelson, Carl L. Berg, Mustafa R. Bashir

    Purpose: To determine whether reader perception of a capsule affects reader interpretation of washout in hypervascular liver nodules at dynamic magnetic resonance imaging (MRI) in patients at risk for hepatocellular carcinoma (HCC). Materials and Methods: This retrospective study was Institutional Review Board (IRB)-approved and Health Insurance Portability and Accountability Act (HIPAA)-compliant, with waiver of informed consent. MRI reports for 111 hypervascular liver nodules (median 2.0 cm, range 1.0-17.8 cm) in 62 patients were reviewed, and the presence/absence of capsule and washout were recorded for one reading. A second independent study reading was also performed. The signal intensity ratio (SIR) for each nodule and liver parenchyma was measured. An objective SIR threshold was identified for nodules without capsules that correctly classified the presence/absence of washout, then applied to nodules with capsules to classify them as having /not having objective washout. Nodules were categorized as definite /not definite HCC using subjective and objective washout, based on LI-RADS, OPTN, AASLD, and EASL criteria, and proportions compared using McNemar's test. Results: Agreement on nodule features was high for Readings 1 and 2 (kappa = 0.70-0.82). For Reading 1, 71 nodules lacked capsules (43 with and 28 without subjective washout); an SIR threshold of 0.88 classified the presence/absence of washout correctly in 94% (67/71, P < 0.001). Forty nodules had capsules; although all had subjective washout (100%, 40/40), 75% (30/40) had objective washout (P < 0.05). Using objective washout caused 4.5% (3/66; LI-RADS, OPTN) and 12% (10/83; AASLD, EASL) of nodules to be recategorized from definite HCC to not definite HCC. Conclusion: Reader perception of capsule affects interpretation of washout. This effect can influence nodule categorization using imaging-based diagnostic systems.

    WILEY-BLACKWELL, 2016年06月, JOURNAL OF MAGNETIC RESONANCE IMAGING, 43 (6), 1337 - 1345, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Keitaro Sofue, Daniele Marin, Tracy A. Jaffe, Rendon C. Nelson, Mustafa R. Bashir

    Purpose: To determine whether triple-arterial phase acquisition with fluoroscopic triggering can provide both well-timed early and late hepatic arterial phase (HAP) images more frequently than when using a fixed-time delay during gadoxetic acid-enhanced magnetic resonance imaging (MRI). Materials and Methods: Written informed consent was obtained for this Institutional Review Board (IRB)-approved prospective, Health Insurance Portability and Accountability Act (HIPAA)-compliant study. Ninety patients underwent gadoxetic acid-enhanced MRI at 3T with a single-breath-hold triple-arterial phase acquisition using either a fixed-time delay (n=45) or fluoroscopic triggering injection protocol (n=45). Three radiologists, blinded to method of timing and other data, independently determined whether well-timed early or late HAP were obtained for each arterial phase image set and assessed for transient severe motion (TSM). Rates of successful HAP acquisitions and of TSM were compared between the two protocols using chi(2) or Fisher's exact test. Results: The rate of successful acquisition of late HAP images was similar in the two groups (93% [42/45] for fixed-time delay vs. 98% [44/45] for fluoroscopic triggering, P=0.62). There was a trend toward higher rates of successful acquisition of both early and late HAP images in the fluoroscopic triggering group (69% [31/45] vs. 49% [22/45], P=0.05). TSM occurred in five patients (6% [5/90]) and at similar frequencies in the two groups (2% [1/45] vs. 9% [4/45], P=0.36). Conclusion: Triple-arterial phase acquisition with fluoroscopic triggering tended to provide both well-timed early and late HAP images more frequently than when using a fixed-time delay during gadoxetic acid-enhanced MRI.

    WILEY-BLACKWELL, 2016年05月, JOURNAL OF MAGNETIC RESONANCE IMAGING, 43 (5), 1073 - 1081, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Masakatsu Tsurusaki, Keitaro Sofue, Hiroyoshi Isoda, Masahiro Okada, Kazuhiro Kitajima, Takamichi Murakami

    Gadoxetic acid-enhanced magnetic resonance imaging (MRI) has an important role in preoperative evaluation of hepatocellular carcinoma (HCC). However, no studies have prospectively performed intraindividual comparison of gadoxetic acid-enhanced 3T MRI and multidetector-row computed tomography (MDCT) with histopathological examination for the detection of HCCs. We prospectively compared the efficacies of gadoxetic acid-enhanced MRI and multiphasic contrast-enhanced MDCT with that of histopathological examination, used as a reference standard, for the detection of HCC in surgical candidates. The study was approved by the institutional review boards at each of four centers. Patients scheduled to undergo multiphasic CT, gadoxetic acid-enhanced MRI, and liver surgery were prospectively included in this study. The diagnostic abilities of MRI and CT were evaluated and compared on the basis of sensitivity and positive predictive value for detection of and differentiation between HCCs and benign lesions. Fifty-four patients with 83 histopathologically confirmed HCCs were included in the study. Combined interpretation of the dynamic and hepatobiliary phases of gadoxetic acid-enhanced MRI showed statistically higher sensitivity for lesion detection (83 %) than did interpretation of multiphasic MDCT images (70 %; p < 0.001). The mean area under each alternative free-response receiver operating characteristics curve was significantly higher for MR images (0.927) than for CT images (0.864, p < 0.01). The sensitivity for preoperative detection of HCCs was higher for gadoxetic acid-enhanced MRI than for multiphasic MDCT imaging.

    SPRINGER JAPAN KK, 2016年01月, JOURNAL OF GASTROENTEROLOGY, 51 (1), 71 - 79, 英語, 国内誌

    [査読有り]

    研究論文(学術雑誌)

  • Keitaro Sofue, Achille Mileto, Brian M. Dale, Xiaodong Zhong, Mustafa R. Bashir

    PurposeTo assess the interexamination repeatability and spatial heterogeneity of liver iron and fat measurements using a magnetic resonance imaging (MRI)-based multistep adaptive fitting algorithm. Materials and MethodsThis prospective observational study was Institutional Review Board-approved and Health Insurance Portability and Accountability Act-compliant. Written informed consent was waived. In all, 150 subjects were imaged on 3T MRI systems. A whole-liver volume acquisition was performed twice using a six-echo 3D spoiled gradient echo sequence during two immediately adjacent examinations. Colocalized regions of interest (ROIs) in three different hepatic segments were placed for R-2* and proton density fat fraction (PDFF) measurements by two readers independently. Mean R-2* and PDFF values between readers and acquisitions were compared using the Wilcoxon signed-rank test, intraclass correlation coefficients (ICCs), linear regression, Bland-Altman analysis, and analysis of variance (ANOVA). ResultsThe mean R-2* and PDFF values across all ROIs and measurements were 51.225.2 s(-1) and 6.9 +/- 6.4%, respectively. Mean R-2* and PDFF values showed no significant differences between the two acquisitions (P=0.05-0.87). Between the two acquisitions, R-2* and PDFF values demonstrated almost perfect agreement (ICCs=0.979-0.994) and excellent correlation (R-2=0.958-0.989). Bland-Altman analysis also demonstrated excellent agreement. In the ANOVA, the individual patient and ROI location were significant effects for both R-2* and PDFF values (P<0.05). ConclusionMRI-based R-2* and PDFF measurements are repeatable between examinations. Between-measurement changes in R-2* of more than 10.1 s(-1) and in PDFF of more than 1.7% are likely due to actual tissue changes. Liver iron and fat content are variable between hepatic segments. J. Magn. Reson. Imaging 2015;42:1281-1290.

    WILEY-BLACKWELL, 2015年11月, JOURNAL OF MAGNETIC RESONANCE IMAGING, 42 (5), 1281 - 1290, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Keitaro Sofue, Yasuaki Arai, Yoshito Takeuchi, Masakatsu Tsurusaki, Noriaki Sakamoto, Kazuro Sugimura

    Background/Purpose: To evaluate the technical success and complications of image-guided central venous port (CVP) placement with subclavian vein (SCV) access in pediatric oncology population. Materials and methods: Ninety-two children (52 boys, 40 girls; mean age, 8.5 years) underwent CVP implantation under local anesthesia with conscious sedation. SCV access was firstly attempted under ultrasonographic guidance and CVP implantation was performed under fluoroscopic guidance. Technical success, peri-procedural (<24 h) complication, and post-procedural (>24 h) complication were assessed. Results: In total, 102 CVPs were implanted in 92 children with a mean catheter time of 364 days (total, 38,224 days; range, 14-1911 days). In three small children, conversion of SCV access to internal jugular vein access yielded a primary technical success rate of 97.1% and overall technical success rate of 100%. Three minor peri-procedural complications were observed (2.9%) and seven post-procedural infectious complications occurred (infection rate, 6.7%; 0.18/1000 catheter days). No pneumothorax, catheter malposition, venous thrombosis, or mortality occurred. Conclusion: Image-guided CVP placement with SCV access in a pediatric population was performed with high technical success and low complication rate without general anesthesia. This procedure can be taken into account as a choice of procedure when internal jugular venous access is not possible. (C) 2015 Elsevier Inc. All rights reserved.

    W B SAUNDERS CO-ELSEVIER INC, 2015年10月, JOURNAL OF PEDIATRIC SURGERY, 50 (10), 1707 - 1710, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Keitaro Sofue, Deepak S. Vikraman, Tracy A. Jaffe, Gaurav N. Chaubal, Mustafa R. Bashir

    Torsion of an allograft kidney is an extremely rare and potentially reversible complication. Imaging diagnosis plays a crucial role because of the absence of specific clinical features. We report 2 cases in which kidney torsion after simultaneous kidney-pancreas transplant was diagnosed by ferumoxytol-enhanced magnetic resonance imaging/angiography and present a review of the relevant literature. Radiologists and clinicians should be aware of this entity because graft salvage depends on rapid diagnosis and surgical detorsion.

    LIPPINCOTT WILLIAMS & WILKINS, 2015年07月, JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 39 (4), 506 - 509, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Kazuhiro Kitajima, Yuko Suenaga, Yoshiko Ueno, Tetsuo Maeda, Yasuhiko Ebina, Hideto Yamada, Takashi Okunaga, Kazuhiro Kubo, Keitarou Sofue, Tomonori Kanda, Yukihisa Tamaki, Kazuro Sugimura

    Purpose To evaluate the usefulness of metabolic parameters obtained by F-18-FDG PET/CT for preoperative stratification of high-risk and low-risk endometrial carcinomas. Methods Preoperative F-18-FDG PET/CT was performed in 56 women with endometrial cancer. Maximum standardized uptake values (SUVmax), metabolic tumour volume (MTV) and total lesion glycolysis (TLG) of primary tumours were compared with clinicopathological features of surgical specimens. Diagnostic performance in terms of differentiation of low-risk disease (endometrioid histology, histological grade 1 or 2, invasion of less than half of the myometrium, and FIGO stage I) from high-risk disease was assessed. Results MTV and TLG were significantly higher in patients with higher histological grade (p = 0.0026 and p = 0.034), larger tumour size (p = 0.002 and p = 0.0017), lymphovascular space involvement (LVSI; p = 0.012 and p = 0.0051), myometrial invasion (p = 0.027 and p = 0.031), cervical stromal invasion (p = 0.023 and p = 0.014), ovarian metastasis (p = 0.00022 and p = 0.00034), lymph node metastasis (p < 0.0001 and p < 0.0001), and higher FIGO stage (p = 0.0011 and p = 0.00048). SUVmax was significantly higher in patients with larger tumour size (p = 0.0025), LVSI (p = 0.00023) and myometrial invasion (p < 0.0001). The areas under the ROC curves (AUCs) for distinguishing high-risk from low-risk carcinoma were 0.625, 0.829 and 0.797 for SUVmax, MTV and TLG, respectively. AUCs for both MTV and TLG were significantly larger than that for SUVmax (p = 0.0049 and p = 0.021). The optimal TLG cut-off value of 70.2, determined by ROC analysis, was found to have 72.0 % sensitivity and 74.2 % specificity for risk stratification. Conclusion MTV and TLG of primary endometrial cancer show better correlations with clinicopathological features and are more useful for differentiating high-risk from low-risk carcinoma than SUVmax.

    SPRINGER, 2015年07月, EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 42 (8), 1268 - 1275, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Keitaro Sofue, Yoshito Takeuchi, Kentaro Shibamoto, Koji Sugimoto, Kazuro Sugimura, Yasuaki Arai

    A 68-year-old man with cholangiocarcinoma underwent percutaneous transhepatic portal embolization to expand the indication for hepatic resection. Selective right posterior portography revealed an intrahepatic portosystemic venous shunt (IPSVS) connecting the segment VII branch to the right hepatic venous branch. An infusion of 50 % glucose solution was given to occlude the shunt. This is novel management for IPSVSs when they are numerous, small, or torturous, and makes the subsequent procedures simpler, shorter, and less expensive.

    SPRINGER, 2014年12月, SURGERY TODAY, 44 (12), 2366 - 2368, 英語, 国内誌

    [査読有り]

    研究論文(学術雑誌)

  • Eisuke Ueshima, Masato Yamaguchi, Akhmadu Muradi, Takuya Okada, Koji Idoguchi, Keitaro Sofue, Yoshikatsu Nomura, Yutaka Okita, Koji Sugimoto

    Endovascular treatment for arteriocaval fistula (ACF) has become the preferred alternative to open repair. However, endoleaks sometimes occur and maintain the ACF. A 64-year-old man presented with persistent fistula after placement of a bifurcated stent-graft for ACF complicating an aortoiliac aneurysm that was maintained by endoleaks from the inferior mesenteric and lumbar arteries. Transarterial embolization of the aneurysm sac and inferior mesenteric artery successfully resolved the problem without any complications observed over 16 months of follow-up. A literature review and discussion of the management options for this entity are presented. A combination of inflow and outflow control is important to obtain better long-term outcomes.

    2014年11月, Journal of vascular and interventional radiology : JVIR, 25 (11), 1809 - 15, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Keitaro Sofue, Masakatsu Tsurusaki, Takamichi Murakami, Shunsuke Onoe, Hiroyuki Tokue, Kentaro Shibamoto, Yasuaki Arai, Kazuro Sugimura

    To compare diagnostic performance in the detection of colorectal liver metastases between 64-detector-row contrast-enhanced CT (CE-CT) alone and the combination of CE-CT and gadoxetic acid-enhanced MRI (EOB-MRI) at 3.0T, and to assess whether EOB-MRI in addition to CE-CT results in a change to initially planned operative strategy. A total of 39 patients (27 men, mean age 65 years) with 85 histopathologically confirmed liver metastases were included. At EOB-MRI, unenhanced (T1- and T2-weighted), dynamic, and hepatocyte-phase images were obtained. At CE-CT, four-phase dynamic contrast-enhanced images were obtained. One on-site reader and three off-site readers independently reviewed both CE-CT alone and the combination of CE-CT and EOB-MRI. Sensitivity, positive predictive value, and alternative free-response receiver operating characteristic (AFROC) method were calculated. Differences in therapeutic strategy before and after the EOB-MRI examination were also evaluated. Sensitivity and area under the AFROC curve with the combination of CE-CT and EOB-MRI were significantly superior to those with CE-CT alone. Changes in surgical therapy were documented in 13 of 39 patients. The combination of CE-CT and EOB-MRI may provide better diagnostic performance than CE-CT alone for the detection of colorectal liver metastases, and EOB-MRI in addition to CE-CT resulted in changes to the planned operative strategy in one-third of the patients. aEuro cent Accurate preoperative imaging is essential for surgical planning and successful hepatic resection. aEuro cent Combination of CE-CT and EOB-MRI is useful to detect colorectal liver metastases. aEuro cent EOB-MRI combined with CE-CT contributes to determine the correct therapeutic strategy.

    SPRINGER, 2014年10月, EUROPEAN RADIOLOGY, 24 (10), 2532 - 2539, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • K. Sofue, Y. Arai, K. Shimada, Y. Takeuchi, T. Kobayashi, M. Satake, K. Sugimura

    Background: This study aimed to evaluate the safety and efficacy of preoperative right portal vein embolization (PVE) with absolute ethanol in patients with hepatobiliary malignancies. Methods: PVE was performed via a percutaneous transhepatic ipsilateral approach, and the right portal branch was embolized with absolute ethanol. Technical success and complications following PVE, and changes in liver enzyme levels were evaluated. Changes in future liver remnant (FLR) and FLR/total functional liver volume ratio were calculated. Complications following hepatic resection were assessed. Results: A total of 83 patients with hepatobiliary malignancies (53 men, 30 women; mean age 68 years) underwent right PVE. Tumour types were hilar cholangiocarcinoma (37), liver metastases (14), gallbladder cancer (13), intrahepatic cholangiocellular carcinoma (10) and hepatocellular carcinoma (HCC) (9). PVE was performed successfully in all patients. Four patients (5 per cent) developed complications following PVE (liver abscess 2, left portal vein thrombosis 1, pseudoaneurysm 1), but this did not preclude hepatic resection. Liver enzyme levels rose transiently after PVE. The mean FLR and FLR/total functional liver volume increased after PVE (from 366 to 513 cm(3) and from 31 to 43 per cent respectively; both P < 0 001). Changes in the FLR and FLR/total functional liver volume ratio were comparable between patients with HCC and those with other malignancies (42 and 44 per cent, and 12 and 12 per cent, respectively). Sixty-nine of 83 patients underwent hepatic resection at a median of 25 days after PVE, with no postoperative mortality. Conclusion: Preoperative right PVE with absolute ethanol is safe and effective for induction of selective hepatic hypertrophy in patients with hepatobiliary malignancy.

    WILEY-BLACKWELL, 2014年08月, BRITISH JOURNAL OF SURGERY, 101 (9), 1122 - 1128, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Noriaki Sakamoto, Masato Yamaguchi, Keitaro Sofue, Akhmadu Muradi, Koji Idoguchi, Takuya Okada, Eisuke Ueshima, Koji Sugimoto

    Ectopic variceal hemorrhage caused by sinistral portal hypertension after splenic vein ligation during a pyloric-preserving pancreatoduodenectomy is a rare entity. We report the case of a 58-year-old man with symptoms of refractory melena. The varices could not be treated endoscopically and surgery was considered unsuitable due to severe adhesions and altered anatomy. Following clinical failure of partial splenic embolization, an alternative obliteration method by a retrograde trans-portal-venous approach was successfully performed and resolved the problem. It seems to be an effective method for ectopic variceal bleeding, especially when other interventions are unavailable or highly risky.

    2014年08月, Japanese journal of radiology, 32 (8), 487 - 90, 英語, 国内誌

    [査読有り]

    研究論文(学術雑誌)

  • Eisuke Ueshima, Masato Yamaguchi, Takeshi Ueha, Akhmadu Muradi, Takuya Okada, Koji Idoguchi, Keitaro Sofue, Toshihiro Akisue, Masahiko Miwa, Masahiko Fujii, Koji Sugimoto

    PURPOSE: To evaluate the efficacy of intraarterial infusion of CO2-saturated solution in rabbit VX2 thigh tumors. MATERIALS AND METHODS: Fourteen Japanese white rabbits had VX2 tumors implanted in the right femoral muscle 3 weeks before intraarterial infusion. Rabbits were divided into control and CO2 groups (n = 7 each). Fifty milliliters of solution (saline solution and CO2-saturated solution for the control and CO2 groups, respectively) was administered via a 24-gauge catheter in the ipsilateral iliac artery close to the feeding artery of the VX2 tumor. All rabbits were killed for tumor harvest on day 3 after the procedure. Tumor volume was evaluated with in vivo direct caliper measurement and contrast-enhanced computed tomography (CT). Tumor apoptotic changes were examined by DNA fragmentation assay and immunoblot analysis. The tumor growth ratio and apoptotic cell rate were analyzed. RESULTS: Body weight was equally increased in both groups, but the mean tumor growth ratio was significantly decreased in the CO2 group compared with the control group (-9.5% ± 7.9 vs 27.2% ± 6.6 and 4.1% ± 4.4 vs 35.7% ± 4.5 measured by calipers and contrast-enhanced CT, respectively; P < .01). Apoptotic activity in the CO2 group was higher than in the control group (number of apoptotic cells per area, 215.0 ± 58.7 vs 21.8 ± 5.4; adjusted relative density of cleaved caspase-3, 0.23 ± 0.07 vs 0.04 ± 0.01; P < .01). CONCLUSIONS: Intraarterial infusion of CO2-saturated solution inhibits rabbit VX2 thigh tumor growth by activation of apoptotic cell death through cleaved caspase-3 upregulation.

    2014年03月, Journal of vascular and interventional radiology : JVIR, 25 (3), 469 - 76, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • 上腹部ダイナミックCTにおけるボーラストラッキングの最適化

    根宜 典行, 香川 清澄, 竹本 洋太, 村上 徹, 祖父江 慶太郎, 吉川 武, 大野 良治

    (公社)日本放射線技術学会, 2014年02月, 日本放射線技術学会総会学術大会予稿集, 70回, 279 - 279, 日本語

  • Keitaro Sofue, Yasuaki Arai, Yoshito Takeuchi, Kazuro Sugimura

    Purpose: To evaluate the efficacy and outcome of a flow confirmation study (FCS) in oncologic outpatients undergoing chemotherapy suspected of a central venous port (CVP) system-related mechanical complication. Materials and methods: A total of 66 patients (27 men, 39 women; mean age, 60 years) received FCS for the following reasons: prolonged infusion time during chemotherapy (n = 32), inability to inject saline fluid (n = 15), lateral neck and/or back pain (n = 6), subcutaneous extravasation of anticancer drug (n = 5), arm swelling (n = 4), and inability to puncture the port (n = 4). FCS consisted of examining the position of CVP, potential secondary shifts or fractures, and integrity of the system using contrast material through the port. Results: Of the 66 patients, 43 had an abnormal finding uncovered by FCS. The most frequent abnormal findings was catheter kinking (n = 22). Explantation and reimplantation of the CVP system was required in 21 of the 66 patients. Remaining 45 patients were able continue using the CVP system after the FCS without any system malfunction. Conclusion: FCS was effective for evaluating CVP system-related mechanical complications and was useful for deciding whether CVP system explantation and reimplantation was required. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

    ELSEVIER IRELAND LTD, 2013年11月, EUROPEAN JOURNAL OF RADIOLOGY, 82 (11), E691 - E696, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • 腹部大動脈瘤下大静脈穿破に対し緊急EVARおよび追加塞栓を施行した1例

    上嶋 英介, 山口 雅人, 井戸口 孝二, 祖父江 慶太郎, 岡田 卓也, 片山 直人, Muradi Akhmadu, 杉本 孝司, 野村 佳克, 大北 裕

    (一社)日本インターベンショナルラジオロジー学会, 2013年10月, IVR: Interventional Radiology, 28 (4), 494 - 494, 日本語

    [査読有り]

  • 腹腔動脈起始部狭窄に伴う下膵十二指腸動脈瘤破裂に対するTAE後に十二指腸狭窄をきたした1例

    祖父江 慶太郎, 山口 雅人, 井戸口 孝二, 岡田 卓也, 上嶋 英介, Muradi Akhmadu, 片山 直人, 杉本 幸司

    (一社)日本インターベンショナルラジオロジー学会, 2013年10月, IVR: Interventional Radiology, 28 (4), 492 - 492, 日本語

    [査読有り]

    研究論文(その他学術会議資料等)

  • 内視鏡が通過しない高度狭窄を伴った食道癌患者における経皮的胃瘻造設術の検討

    芝本 健太郎, 荒井 保明, 竹内 義人, 曽根 美雪, 岡本 大佑, 菅原 俊祐, 富松 浩隆, 森田 慎一, 中村 智行, 新城 安基, 祖父江 慶太郎, 金澤 右

    (一社)日本インターベンショナルラジオロジー学会, 2013年04月, IVR: Interventional Radiology, 28 (Suppl.), 185 - 185, 日本語

  • Rintaro Hashimoto, Keitaro Sofue, Yoshito Takeuchi, Kentaro Shibamoto, Yasuaki Arai

    A 76-year-old woman with hepatitis C cirrhosis presented with tarry stools and hematemesis. An endoscopy demonstrated bleeding duodenal varices in the second portion of the duodenum. Contrast-enhanced computed tomography revealed markedly tortuous varices around the wall in the duodenum. Several afferent veins appeared to have developed, and the right ovarian vein draining into the inferior vena cava was detected as an efferent vein. Balloon-occluded retrograde transvenous obliteration (BRTO) of the varices using cyanoacrylate was successfully performed in combination with the temporary occlusion of the portal vein. Although no previous publications have used cyanoacrylate as an embolic agent for BRTO to control bleeding duodenal varices, this strategy can be considered as an alternative procedure to conventional BRTO using ethanolamine oleate when numerous afferent vessels that cannot be embolized are present. (C) 2013 Baishideng. All rights reserved.

    BAISHIDENG PUBL GRP CO LTD, 2013年02月, WORLD JOURNAL OF GASTROENTEROLOGY, 19 (6), 951 - 954, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Keitaro Sofue, Yoshito Takeuchi, Yasuaki Arai, Kazuro Sugimura

    A71-year-old man with advanced lung cancer developed a life-threatening cerebral edema caused by the acute occlusion of a superior vena cava (SVC) stent and was successfully treated by an additional stent placement. Although stent occlusion is a common early complication, no life-threatening situations have been reported until now. Our experience highlights the fact that acute stent occlusion can potentially lead to the complete venous shutdown of the SVC, resulting in life-threatening cerebral edema, after SVC stent placement. Immediate diagnosis and countermeasures are required. © 2012 Springer Science+Business Media, LLC and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE).

    2013年02月, CardioVascular and Interventional Radiology, 36 (1), 272 - 275, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • 出血性輸入脚静脈瘤に対し経皮経肝的B-RTOで治療し得た1例

    坂本 憲昭, 山口 雅人, 祖父江 慶太郎, 上嶋 英介, 井戸口 孝二, 奥野 晃章, 藤井 正彦, 杉村 和朗, 杉本 幸司

    (一社)日本インターベンショナルラジオロジー学会, 2013年02月, IVR: Interventional Radiology, 28 (1), 108 - 108, 日本語

    研究論文(その他学術会議資料等)

  • Keitaro Sofue, Koji Sugimoto, Takeki Mori, Shinichi Nakayama, Masato Yamaguchi, Kazuro Sugimura

    Isolated iliac vein injury caused by blunt pelvic trauma is a rare condition that is difficult to diagnose and often fatal. We report a case of a 52-year-old female who presented with life-threatening isolated iliac vein injury caused by blunt pelvic trauma that was successfully managed with endovascular uncovered stent placement. Although further studies are warranted to clarify the hemostatic mechanism, uncovered stent placement can be considered as an alternative treatment option to covered stent placement for life-threatening iliac vein injury when a covered stent is not rapidly available.

    SPRINGER, 2012年10月, JAPANESE JOURNAL OF RADIOLOGY, 30 (8), 680 - 683, 英語, 国内誌

    [査読有り]

    研究論文(学術雑誌)

  • Yusuke Yamamoto, Kazuaki Shimada, Yoshito Takeuchi, Keitaro Sofue, Kentaro Shibamoto, Satoshi Nara, Minoru Esaki, Yoshihiro Sakamoto, Tomoo Kosuge, Nobuyoshi Hiraoka

    Precise assessment of retroperitoneal invasion is clinically important to allow the achievement of negative margin resections. The clinical records of 132 patients who underwent macroscopic curative pancreaticoduodenectomy for invasive ductal carcinoma of the pancreas between 2004 and 2008 were retrospectively examined. The clinicopathological factors, including retroperitoneal fat infiltration classified into four groups by multidetector-row computed tomography (MDCT), were analyzed. The relationship between the grade of retroperitoneal fat infiltration and surgical outcomes, as well as various histopathological factors, was also investigated. The 5 year survival rate was 55.6 % for grade 0 infiltration (n = 8), 38.7 % for grade 1 (n = 54), 16.4 % for grade 2 (n = 49), and 0 % for grade 3 (n = 21). There were significant differences in survival in each group. Extrapancreatic nerve invasion and the surgical margin status were significantly associated with retroperitoneal fat infiltration demonstrated on MDCT. According to the grading classification among the 43 patients with pathological portal vein invasion, the 5 year survival rate was 45.9 % for patients with grade 1, which was significantly better survival that those with grade 2 (P = 0.007). The grading criteria for retroperitoneal fat infiltration may be useful as a predictor of survival after pancreaticoduodenectomy for pancreatic head carcinoma. Pancreaticoduodenectomy with portal vein resection could provide favorable survival in patients with grade 1 retroperitoneal fat infiltration, even if histopathological portal vein invasion is present.

    SPRINGER, 2012年09月, WORLD JOURNAL OF SURGERY, 36 (9), 2192 - 2201, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Keitaro Sofue, Yasuaki Arai, Yoshito Takeuchi, Hiroyasu Fujiwara, Hiroyuki Tokue, Kazuro Sugimura

    Purpose: To evaluate the safety and efficacy of primary metallic biliary stent placement with tract embolization in patients with massive ascites. Materials and Methods: Sixteen patients with malignant biliary obstruction and massive ascites (age range, 44-79 y; median age, 59 y) were treated with primary percutaneous stent placement with tract embolization. These patients were unsuitable candidates for endoscopic intervention. Etiologies of biliary obstruction were gastric cancer with hilar nodal metastases (n = 9), pancreatic carcinoma (n = 5), cholangiocarcinoma (n = I), and gallbladder carcinoma (n = I). Eight patients had nonhilar lesions and the remaining eight had hilar lesions. Percutaneous accesses to the biliary system and stent placements were performed in a one-step procedure, and catheters were removed with tract embolization with metallic coils. Results: Stent placement and tract embolization were successful in all patients, without external drainage catheters left in place. Significant reduction of serum bilirubin level was observed in 14 patients (87.5%). No bile peritonitis or intraperitoneal hemorrhage occurred. Major complications included postprocedural cholangitis (12.5%), bloody bowel discharge (6.2%), and right pleural effusion (25.0%). One patient who died 19 days after intervention was deemed to represent a procedure-related mortality. During the survival period (range, 19-175 d; median, 66 d), stent occlusion was noted in two patients at 6 and 159 days after the procedure. Primary stent patency was achieved in 14 patients (87.5%). Conclusions: Primary biliary stent placement with tract embolization is technically safe and offers an effective palliative treatment option for patients with malignant biliary obstruction and massive ascites when endoscopic intervention is not possible.

    ELSEVIER SCIENCE INC, 2012年04月, JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY, 23 (4), 521 - 527, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Keitaro Sofue, Ukihide Tateishi, Masakatsu Tsurusaki, Yasuaki Arai, Naoya Yamazaki, Kazuro Sugimura

    Purpose: To evaluate the magnetic resonance (MR) imaging feature of suspected hepatic metastasis in patients with malignant melanoma which showed intermediate findings on screened contrast-enhanced computed tomography (CECT). Materials and methods: MR imaging was performed in 38 patients (22 men, 16 women; mean age, 58 years) whose CECT findings were intermediate. Hepatic metastases had been diagnosed on MR imaging in 23 of the 38 patients. Verification of hepatic metastasis was made by histological examination: ultrasonographic-guided needle biopsy (n = 3), autopsy (n = 3), and surgical resection (n = 1), or by an obvious progression in number and/or size of the lesions on follow-up MR imaging (n = 24). Two diagnostic radiologists reviewed MR images by consensus. The median follow-up duration was 14.2 months. Results: Abnormal findings were detected in 31 patients on MR images, and undetected in the remaining seven patients resulting in false-positive on CECT. The mean size of the lesion was 11.0 mm. False-positive results were obtained in two lesions which disappeared on follow-up MR imaging. In six patients, lesions were considered as hepatic cysts on MR images. As a result, a total of 35 hepatic metastases were detected on MR images. Of these, 18 patients demonstrated typical melanotic appearance on MR images which showed shortened T1 and T2 relaxation times, and five patients demonstrated atypical melanotic appearance. In 16 patients, extra-hepatic metastases were also developed. Conclusion: MR imaging could rule out hepatic metastasis in patients with malignant melanoma which showed intermediate findings on screened CECT, and could detect additional extra-hepatic metastases. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

    ELSEVIER IRELAND LTD, 2012年04月, EUROPEAN JOURNAL OF RADIOLOGY, 81 (4), 714 - 718, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Keitaro Sofue, Masakatsu Tsurusaki, Ryota Kawasaki, Masahiko Fujii, Kazuro Sugimura

    Purpose: To evaluate two different iodine concentrations of contrast material for detecting hypervascular hepatocellular carcinomas (HCCs) in cirrhotic liver by multi-detector row helical CT (MDCT) when a fixed contrast material volume and injection rate is used. Materials and methods: Institutional Review Board approval was obtained, and informed consent was obtained from all patients. In this prospective study, 105 patients were randomly assigned a group A (an iodine concentration of 300 mg I/mL), and a group B (an iodine concentration of 370 mg I/mL). In both groups the volume of contrast material was 100 mL and the injection rate was 4 mL/s. Fifty-two patients had 122 hypervascular HCCs. The diagnosis of HCCs was established histopathologically (n = 24) and by imaging findings (n = 98). Three readers independently analyzed four image sets: an arterial phase (AP), a portal phase (PP), an equilibrium phase (EP), and combined all three phase images set. Sensitivity, specificity, and diagnostic accuracy were calculated by receiver operating characteristic (ROC) analysis. Results: The mean sensitivity for detecting hypervascular HCCs of the AP set, EP set, and combination set in group B (0.94, 0.81, and 0.93) was significantly higher than in group A (0.84, 0.69, and 0.80). Area under the ROC curve of the AP set and the combination set in group B (0.974 and 0.981) was significantly higher than in group A (0.939 and 0.958). Conclusion: At the same contrast material volume and injection rate, higher iodine concentration of contrast material was effective for detecting hypervascular HCCs by MDCT. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

    ELSEVIER IRELAND LTD, 2011年12月, EUROPEAN JOURNAL OF RADIOLOGY, 80 (3), E237 - E242, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Keitaro Sofue, Masakatsu Tsurusaki, Hiroyuki Tokue, Yasuaki Arai, Kazuro Sugimura

    To compare quantitatively and qualitatively hepatocyte-phase images obtained 10 and 20 min (Images-10, and Images-20) after injection of gadolinium-ethoxybenzyl-diethylenetriamine-pentaacetic acid (Gd-EOB-DTPA) to detect liver metastases from colorectal carcinoma on 3.0 T MR imaging. A total of 48 patients (26 men, 22 women; mean age, 64 years) with 88 histopathologically confirmed liver metastases underwent Gd-EOB-DTPA-enhanced MR imaging. Tumour-to-liver contrast-to-noise ratio (CNR), signal intensity gain (SIG) of liver parenchyma and overall image quality were analysed. Two radiologists independently reviewed two sets of MR images: set 1, unenhanced (T1- and T2-weighted), dynamic images and Images-10; set 2, unenhanced, dynamic and Images-20. Sensitivity and positive predictive value (PPV) to detect liver metastases, and diagnostic performance using the alternative free-response receiver operating characteristics (AFROC) method were calculated. The mean tumour-to-liver CNR, SIG of liver parenchyma and overall image quality on Images-20 were significantly higher than those on Images-10. The overall image quality of "fair to excellent" was achieved on both images in 93.8% of the patients. Sensitivity, PPV and area under the AFROC curve on set 1 were similar to set 2, including lesions < 1 cm. In detecting liver metastases from colorectal carcinoma, Images-10 could replace Images-20 in 3.0 T MR imaging.

    SPRINGER, 2011年11月, EUROPEAN RADIOLOGY, 21 (11), 2336 - 2343, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Hiroyuki Tokue, Yoshito Takeuchi, Ketaro Sofue, Yasuaki Arai, Yoshito Tsushima

    INTRODUCTION: Percutaneous transhepatic portal embolization is often performed to expand the indications for hepatic resection. Various etiologies of hepatic artery pseudoaneurysm have been reported, but regardless of the etiology, hepatic artery pseudoaneurysm is usually managed with an endovascular approach or open surgery, depending on the location and clinical symptomatology. However, it is difficult to manage hepatic artery pseudoaneurysm after percutaneous transhepatic portal embolization, since embolization of the hepatic artery may cause hepatic infarction CASE PRESENTATION: A 58-year-old Japanese man with hilar bile duct cancer underwent percutaneous transhepatic portal embolization to expand the indication for hepatic resection. Two days after percutaneous transhepatic portal embolization, our patient suddenly complained of abdominal pain. Contrast-enhanced computed tomography confirmed a pseudoaneurysm arising from a segmental branch of his right hepatic artery. Since embolization of the hepatic arterial branches may cause hepatic infarction, ultrasound-guided thrombin injection therapy was successfully performed for the pseudoaneurysm. CONCLUSION: We performed a thrombin injection instead of arterial embolization to avoid hepatic infarction. The rationale of this choice may be insufficient. However, ultrasound-guided percutaneous thrombin injection therapy may be considered as an alternative to percutaneous transarterial embolization or surgical intervention for an iatrogenic hepatic artery pseudoaneurysm.

    2011年10月21日, Journal of medical case reports, 5, 518 - 518, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Hiroyuki Tokue, Yoshito Takeuchi, Yasuaki Arai, Keitaro Sofue, Noriaki Sakamoto, Yoshito Tsushima, Keigo Endo

    Purpose: To evaluate a new modified peritoneovenous shunt therapy, the externalized peritoneovenous shunt (EPVS) system placement, used to treat patients with malignant ascites. Methods: We retrospectively reviewed 10 patients, who were not suited for conventional peritoneovenous shunts (PVS), with malignant ascites, which was refractory to medical therapies. Patient characteristics, technical success, efficacy, duration of EPVS placement, adverse events, and outcome were evaluated. Clinical efficacy of the EPVS was evaluated by the change in subjective symptoms. Results: The primary reasons for applying EPVS were severe anasarca in 4 patients, potential PVS dysfunction in 3 patients, poor performance status in 2 patients, and a history of PVS occlusion in 1 patient. EPVS was successfully placed in all patients, and it provided clinical efficacy in 8 patients (80%). Early death occurred within 7 days after EPVS placement in 2 patients because of renal failure. The median duration of EPVS placement was 10.4 days (range, 2-28 days). In 6 patients (60%), the EPVS was exchanged to conventional PVS sequentially, since the initial EPVS placement resulted in an improvement of the subjective symptoms of the patients, without serious complications. Conclusion: EPVS placement may be an option for patients with malignant ascites who may not be appropriate for conventional PVS placement.

    BIOMED CENTRAL LTD, 2011年07月, WORLD JOURNAL OF SURGICAL ONCOLOGY, 9, 82 - 82, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • 大腸癌肝転移の治療方針決定におけるGd-EOB-DTPA造影MRIの有用性

    鶴崎 正勝, 尾上 俊介, 祖父江 慶太郎, 徳江 浩之, 稗田 洋子, 北垣 一, 荒井 保明, 杉村 和朗

    (公社)日本医学放射線学会, 2011年02月, 日本医学放射線学会学術集会抄録集, 70回, S181 - S181, 日本語

    [査読有り]

  • 大腸癌肝転移における3T-MRIを用いたGd-EOB-DTPA造影MRIの診断能 手術症例での検討

    稗田 洋子, 鶴崎 正勝, 祖父江 慶太郎, 徳江 浩之, 北垣 一, 荒井 保明, 杉村 和朗

    (公社)日本医学放射線学会, 2011年02月, 日本医学放射線学会学術集会抄録集, 70回, S181 - S182, 日本語

    [査読有り]

  • Keitaro Sofue, Masakatsu Tsurusaki, Mototaka Miyake, Aine Sakurada, Yasuaki Arai, Kazuro Sugimura

    To prospectively compare the diagnostic performance of superparamagnetic iron oxide (SPIO)-enhanced magnetic resonance (MR) imaging at 3.0 T and 1.5 T for detection of hepatic metastases. A total of 28 patients (18 men, 10 women; mean age, 61 years) with 80 hepatic metastases were prospectively examined by SPIO-enhanced MR imaging at 3.0 T and 1.5 T. T1-weighted gradient-recalled-echo (GRE) images, T2*-weighted GRE images and T2-weighted fast spin-echo (SE) images were acquired. The tumour-to-liver contrast-to-noise ratio (CNR) of the lesions was calculated. Three observers independently reviewed each image. Image artefacts and overall image quality were analysed, sensitivity and positive predictive value for the detection of hepatic metastases were calculated, and diagnostic accuracy using the receiver-operating characteristics (ROC) method was evaluated. The tumour-to-liver CNRs were significantly higher at 3.0 T. Chemical shift and motion artefact were more severe, and overall image quality was worse on T2-weighted fast SE images at 3.0 T. Overall image quality of the two systems was similar on T1-weighted GRE images and T2*-weighted GRE images. Sensitivity and area under the ROC curve for the 3.0-T image sets were significantly higher. SPIO-enhanced MR imaging at 3.0 T provided better diagnostic performance for detection of hepatic metastases than 1.5 T.

    SPRINGER, 2010年09月, EUROPEAN RADIOLOGY, 20 (9), 2265 - 2273, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • がんの局所療法 がん緩和医療とIVR

    竹内 義人, 荒井 保明, 高橋 正秀, 藤原 寛康, 祖父江 慶太郎, 徳江 浩之, 芝 奈津子, 中村 智行

    (一社)日本癌治療学会, 2010年09月, 日本癌治療学会誌, 45 (2), 471 - 471, 日本語

    [査読有り]

  • 澤田 守男, 祖父江 慶太郎, 立石 宇貴秀, 前田 哲雄, 岩破 一博, 北脇 城

    「産婦人科の進歩」編集室, 2010年08月, 産婦人科の進歩, 62 (3), 299 - 299, 日本語

  • 子宮がん診療における11C-コリンPET/CTの役割

    澤田 守男, 祖父江 慶太郎, 立石 宇貴秀, 前田 哲雄, 岩破 一博, 北脇 城

    「産婦人科の進歩」編集室, 2009年11月, 産婦人科の進歩, 61 (4), 435 - 435, 日本語

  • ガイドライン治療・臨床試験に該当しない症例に対する治療 IVRによる抗がん治療可能状況への導入

    竹内 義人, 荒井 保明, 高橋 正秀, 鶴崎 正勝, 藤原 寛泰, 坂本 憲昭, 祖父江 慶太郎, 徳江 浩之

    (一社)日本癌治療学会, 2009年09月, 日本癌治療学会誌, 44 (2), 342 - 342, 日本語

    [査読有り]

  • IVRのエビデンスを求めて 血管系IVRのエビデンス 画像誘導下CV穿刺法のエビデンス

    竹内 義人, 荒井 保明, 高橋 正秀, 鶴崎 正勝, 藤原 寛康, 坂本 憲昭, 祖父江 慶太郎, 徳江 浩之

    (公社)日本医学放射線学会, 2009年09月, 日本医学放射線学会秋季臨床大会抄録集, 45回, S442 - S442, 日本語

  • Keitaro Sofue, Ukihide Tateishi, Morio Sawada, Tetsuo Maeda, Takashi Terauchi, Daisuke Kano, Yasuaki Arai, Tomio Inoue, Kazuro Sugimura

    The present study was conducted to clarify the role of carbon-11 choline ((11)C-choline) positron emission tomography (PET)/computed tomography (CT) in the management of uterine carcinoma. Twenty-two patients who underwent (11)C-choline PET/CT and pelvic MRI were evaluated retrospectively. The images were reviewed by a board-certified radiologist and a nuclear medicine specialist who were unaware of any clinical information, and a consensus was reached. Diagnostic accuracy of PET/CT was evaluated for staging. The reference standard consisted of histological examination (n = 17) and follow-up conventional CT (n = 5). In five patients with cervical carcinoma, (11)C-choline PET/CT was performed before and after treatment that consisted of cisplatin infusion and subsequent radiotherapy. Standardized uptake value (SUV) was compared with uni-dimensional and volumetric measurements that were made on magnetic resonance images (MRI) before and after treatment. Based on PET/CT interpretations, the reviewers correctly classified T stage in 8 patients (47%), N stage in 21 patients (96%), M stage in 20 patients (91%), and TNM stage in 15 patients (88%). Tumor size, volume, and SUV decreased after treatment in five patients with cervical carcinoma. Using the Pearson correlation test, a significant correlation was found between the reduction rate of SUV and reduction rate of tumor volume. (11)C-choline PET/CT is an accurate means for the management of patients with uterine carcinoma. The combination of (11)C-choline PET/CT and MRI increases the accuracy of staging in patients with uterine carcinoma.

    SPRINGER, 2009年05月, ANNALS OF NUCLEAR MEDICINE, 23 (3), 235 - 243, 英語, 国内誌

    [査読有り]

    研究論文(学術雑誌)

  • Yumiko Yamane, Kazunari Ishii, Kotaro Shimizu, Keitaro Sofue, Toshiki Yoshikawa, Naokazu Miyamoto, Shingo Ohkawa

    We report a 64-year-old male patient with pure transient global amnesia (TGA) who exhibited global cerebral hypoperfusion during an amnesia attack. Initial single photon emission computed tomography (SPECT) performed 3 hours after the onset of the amnesic attack revealed diffuse hypoperfusion in the cerebrum, whereas a second SPECT study, I month later, revealed improvement of cerebral blood flow. This case suggests that SPECT study is useful in revealing the pathophysiological mechanism of TGA and that TGA attacks are associated with global cerebral blood flow change.

    LIPPINCOTT WILLIAMS & WILKINS, 2008年05月, JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 32 (3), 415 - 417, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Atsushi K. Kono, Kazunari Ishii, Keitaro Sofue, Naokazu Miyamoto, Setsu Sakamoto, Etsuro Mori

    Purpose To evaluate a fully automatic computer-assisted diagnostic system for mild dementia with Lewy bodies (DLB), permitting distinction from mild Alzheimer's disease (AD). Methods Using F-18-fluorodeoxyglucose and positron emission tomography (FDG-PET), glucose metabolic images were obtained from mild DLB and mild AD patients. Two groups consisting of 16 mild DLB patients and 21 mild AD patients were recruited for diagnostic evaluation between mild DLB and mild AD. The mean age +/- SD of the mild DLB group and the mild AD group was 74.3 +/- 4.9 and 71.7 +/- 2.1 years, respectively, and the mean scores of the MMSE for the mild DLB and the mild AD group were 21.7 +/- 1.9 and 23.1 +/- 2.1, respectively. A receiver operating characteristic (ROC) analysis was performed to compare the diagnostic performance, in terms of discrimination between DLB and AD, of conventional axial FDG-PET images inspected visually by experts and beginners with that of our fully automatic diagnosis system using the statistical brain mapping method and Z scores obtained with the DLB template. Results The diagnostic performance of the automatic system was comparable to that of visual inspection by experts. The area under the ROC curve for the automatic diagnosis system was 0.77. The mean area under the ROC curve for visual inspection by experts and beginners was 0.76 and 0.65, respectively. Conclusion The fully automatic differential diagnosis system for distinction between mild DLB and AD showed a similar diagnostic accuracy to visual inspection by experts. It would be a useful diagnostic tool to distinguish mild DLB from mild AD in clinical practice.

    SPRINGER, 2007年09月, EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 34 (9), 1490 - 1497, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Kazunari Ishii, Tsutonm Soma, Atsushi K. Kono, Keitaro Sofue, Naokazu Miyamoto, Toshiki Yoshikawa, Etsuro Mori, Kenya Murase

    The aim of this study was to investigate regional differences between morphologic and functional changes in patients with mild dementia with Lewy bodies (DLB) compared with those with Alzheimer's disease (AD). Methods: Twenty patients with very mild DLB (mean age, 74.5 y; mean Mini-Mental State Examination [MMSE] score, 24.0), 20 patients with very mild AD (mean age, 74.1 y; mean MMSE score, 24.0), and 20 age- and sex-matched healthy volunteers (normal controls [NC]) underwent both F-18-FDG PET and 3-dimensional spoiled gradient echo MRI. Fully automatic volumetry of the MRI data was used to obtain whole brain, hippocampal, occipital, and striatal volumes, which were compared with the results of a similar analysis of glucose metabolic data. Results: In DLB patients, volumetric data indicated a significant volume decrease in the striatum, whereas F-18-FDG PET showed significant glucose metabolic reductions in the temporal, parietal, and frontal areas-including in the occipital lobe-compared with those in the NC group. In contrast, in AD patients, both the hippocampal volume and glucose metabolism were significantly decreased, whereas the occipital volume and metabolism were preserved. Conclusion: Comparison of very mild DLB and AD revealed different morphologic and metabolic changes occurring in the medial temporal lobes and the occipital lobe, demonstrating characteristic pathophysiologic differences between these 2 diseases.

    SOC NUCLEAR MEDICINE INC, 2007年05月, JOURNAL OF NUCLEAR MEDICINE, 48 (5), 704 - 711, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • 脳統計学的画像診断法の発展とピットフォール

    石井 一成, 祖父江 慶太郎, 宮本 直和, 吉川 俊紀

    (公社)日本医学放射線学会, 2007年02月, 日本医学放射線学会学術集会抄録集, 66回, S105 - S105, 日本語

  • 腎動脈狭窄に対する経皮的腎血管形成術 腎機能悪化予防についての検討

    祖父江 慶太郎, 宮本 直和, 福田 哲也, 吉川 俊紀, 石井 一成

    (公社)日本医学放射線学会, 2007年02月, 日本医学放射線学会学術集会抄録集, 66回, S257 - S257, 日本語

  • Masahiro Tsujimae, Atsuhiro Masuda, Takuya Ikegawa, Takeshi Tanaka, Jun Inoue, Hirochika Toyama, Keitaro Sofue, Hisahiro Uemura, Shinya Kohashi, Noriko Inomata, Kae Nagao, Shigeto Masuda, Shohei Abe, Masanori Gonda, Kohei Yamakawa, Shigeto Ashina, Yasutaka Yamada, Shunta Tanaka, Ryota Nakano, Arata Sakai, Takashi Kobayashi, Hideyuki Shiomi, Maki Kanzawa, Tomoo Itoh, Takumi Fukumoto, Yoshihide Ueda, Yuzo Kodama

    BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) concomitant with intraductal papillary mucinous neoplasm (IPMN) is defined as PDAC occurring apart from IPMN. This study comprehensively investigated the molecular biologic characteristics of PDAC concomitant with IPMN in major genetic alterations, tumor microenvironment, and prognosis by contrast with those of conventional PDAC. METHODS: The study retrospectively reviewed the data of 158 surgically resected PDAC patients. The driver gene alteration status (KRAS, TP53, CDKN2A, SMAD4, and GNAS) together with the immune and fibrotic status in tumor was evaluated. The prognosis of PDAC concomitant with IPMN and that of conventional PDAC also were compared. RESULTS: No statistically significant difference was found between PDAC concomitant with IPMN and conventional PDAC in the alteration frequency analysis of the major driver genes and the immune and fibrotic status in the tumor microenvironment. Overall survival and disease-free survival between patients who had PDAC concomitant with IPMN and those who had conventional PDAC did not show statistically significant differences in propensity-matched subjects. Furthermore, the co-existence of IPMN was not a poor prognostic factor in the multivariable-adjusted Cox proportional hazards model (hazard ratio, 0.95; 95 % confidence interval, 0.51-1.78). CONCLUSIONS: In this study, PDAC concomitant with IPMN had tumor characteristics similar to those of conventional PDAC in terms of the major driver gene alterations, tumor microenvironment, and prognosis.

    2022年05月23日, Annals of surgical oncology, 英語, 国際誌

    研究論文(学術雑誌)

  • Yushi Tsujita, Keitaro Sofue, Eisuke Ueshima, Yoshiko Ueno, Masatoshi Hori, Takamichi Murakami

    Viral hepatitis was previously the most common cause of chronic liver disease. However, in recent years, nonalcoholic fatty liver disease (NAFLD) cases have been increasing, especially in developed countries. NAFLD is histologically characterized by fat, fibrosis, and inflammation in the liver, eventually leading to cirrhosis and hepatocellular carcinoma. Although biopsy is the gold standard for the assessment of the liver parenchyma, quantitative evaluation methods, such as ultrasound, CT, and MRI, have been reported to have good diagnostic performances. The quantification of liver fat, fibrosis, and inflammation is expected to be clinically useful in terms of the prognosis, early intervention, and treatment response for the management of NAFLD. The aim of this review was to discuss the basics and prospects of MRI-based tissue quantifications of the liver, mainly focusing on proton density fat fraction for the quantification of fat deposition, MR elastography for the quantification of fibrosis, and multifrequency MR elastography for the evaluation of inflammation.

    2022年05月18日, Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine, 英語, 国内誌

    研究論文(学術雑誌)

  • Masahiro Tsujimae, Atsuhiro Masuda, Takuya Ikegawa, Takeshi Tanaka, Jun Inoue, Hirochika Toyama, Keitaro Sofue, Hisahiro Uemura, Shinya Kohashi, Noriko Inomata, Kae Nagao, Shigeto Masuda, Shohei Abe, Masanori Gonda, Kohei Yamakawa, Shigeto Ashina, Yasutaka Yamada, Shunta Tanaka, Ryota Nakano, Arata Sakai, Takashi Kobayashi, Hideyuki Shiomi, Maki Kanzawa, Tomoo Itoh, Takumi Fukumoto, Yoshihide Ueda, Yuzo Kodama

    2022年05月15日, Annals of surgical oncology, 英語, 国際誌

    研究論文(学術雑誌)

  • Hideto Ueki, Tomoaki Terakawa, Yoshiko Ueno, Keitaro Sofue, Shintaro Horii, Yasuyoshi Okamura, Yukari Bando, Takuto Hara, Junya Furukawa, Kenichi Harada, Nobuyuki Hinata, Yuzo Nakano, Takamichi Murakami, Masato Fujisawa

    OBJECTIVE: In renal cell carcinoma with inferior vena cava (IVC) thrombus, adhesion to, or invasion into, the IVC wall will often increase the level of surgical difficulty and even necessitate resection of the IVC. It will generally be difficult to perform an accurate preoperative assessment using the standard imaging modalities of contrast-enhanced computed tomography and standard magnetic resonance imaging (MRI). Cine MRI is an MRI sequence that captures motion to produce detailed information on both the anatomy and the dynamic motion. In the present study, we evaluated the accuracy of preoperative cine MRI for determining the need for IVC wall resection, with validation of the imaging findings according to the intraoperative findings. METHODS: A total of 15 patients who had undergone radical nephrectomy and tumor thrombectomy from May 2018 to April 2020 met the inclusion criteria. The primary outcome of interest was the need for IVC resection because of adhesion or invasion of a venous tumor thrombus. Cine MRI was used to evaluate the blood flow between the tumor thrombus and the IVC wall and the presence of tumor thrombus mobility during free respiration. The sensitivity and specificity were calculated for preoperative cine MRI for determining the need for IVC wall resection. The Fisher exact test was used to determine the association between intraoperative IVC wall resection and the cine MRI findings. Furthermore, receiver operating characteristic curves and the area under the curve were used to compare the accuracy of conventional MRI and cine MRI. RESULTS: Of the 15 patients, 8 (53.3%) had undergone IVC resection. We found that the absence of both dynamic blood flow and tumor thrombus mobility on cine MRI could reliably predict for IVC resection with 100% (95% confidence interval, 51.8%-100%) sensitivity and 85.7% (95% confidence interval, 42.1%-1.00%) specificity. The area under the receiver operating characteristic curve was 0.821 for conventional MRI and 0.929 for cine MRI. CONCLUSIONS: In the preoperative setting, cine MRI could be a helpful examination modality to predict for the need for IVC wall resection for patients with renal cell carcinoma with venous tumor thrombus.

    2022年03月18日, Journal of vascular surgery. Venous and lymphatic disorders, 英語, 国際誌

    研究論文(学術雑誌)

  • Yoshiko Ueno, Tsutomu Tamada, Keitaro Sofue, Yasuyo Urase, Nobuyuki Hinata, Masato Fujisawa, Takamichi Murakami

    Background: Prostate apparent diffusion coefficient (ADC) values calculated from diffusion-weighted imaging have been used for evaluating prostate cancer (PCa) aggressiveness. However, the way of measuring ADC values has varied depending on the study. Purpose: To investigate inter- and intra-reader variability and diagnostic performance of three kinds of shaped 2D regions of interests (ROIs) for tumor ADC measurements in PCa. Material and Methods: Seventy-four patients with PCa undergoing 3-T MRI before surgery were included. Histologic findings from radical prostatectomy specimens were reviewed to define each patient's dominant tumor. Three readers independently measured the tumor ADCs using three different ROI methods: freehand, large-circle, and small-circles ROIs. Readers repeated measurements after 3 weeks. Bland-Altman analysis was performed to evaluate the inter- and intra-reader variability. Receiver Operating Characteristic analysis was used for assessment of tumor aggressiveness for PCa. Results: For intra-reader and inter-reader variability, the mean coefficient of repeatability for freehand ROIs, large-circle ROIs, and small-circles ROIs were as follows: 13.7%, 12.4%, and 11.5%; 9.4%, 9.7%, and 9.5%. For differentiating Gleason score (GS) = 3 + 3 from GS ≥ 3 + 4 tumors, the area under the curves were 0.90 for freehand ROIs, 0.89 for large-circle ROIs, and 0.94 small-circles ROIs (p = 0.31). Conclusion: The variations in ROI method did not have a major influence on intra-reader or inter-reader reproducibility or diagnostic performance for prostate ADC measurements.

    2022年03月, Acta radiologica open, 11 (3), 20584601221086500 - 20584601221086500, 英語, 国際誌

    研究論文(学術雑誌)

  • Takeru Yamaguchi, Keitaro Sofue, Eisuke Ueshima, Yoshiko Ueno, Yushi Tsujita, Shinji Yabe, Sachiyo Shirakawa, Hirochika Toyama, Masatoshi Hori, Takumi Fukumoto, Takamichi Murakami

    BACKGROUND: Gadoxetic acid-enhanced magnetic resonance imaging (MRI) is useful in detecting liver metastases from pancreatic ductal adenocarcinoma (PDAC). However, the long examination time limits its utility in the initial workup of patients with PDAC. PURPOSE: To evaluate the incremental value of an abbreviated gadoxetic acid-enhanced MRI for the detection of liver metastases in patients with PDAC. STUDY TYPE: Retrospective. POPULATION: Patients (N = 130) with potentially resectable PDAC (women, 58 [44.6%]). FIELD STRENGTH/SEQUENCE: 1.5 T and 3 T; gradient dual-echo T1-weighted (in-phase and opposed-phase), fat-suppressed fast spin-echo T2-weighted, single-shot echo-planar diffusion-weighted, and three-dimensional fat-suppressed T1-weighted gradient-echo dynamic contrast-enhanced and hepatobiliary phase sequences, as well as contrast-enhanced computed tomography (CECT). ASSESSMENT: Three radiologists independently reviewed three different image sets to detect liver metastases: set 1, CECT alone; set 2, CECT and abbreviated MRI comprising fat-suppressed T2-weighted, diffusion-weighted, and hepatobiliary phase images; and set 3, CECT and standard gadoxetic acid-enhanced MRI. STATISTICAL TESTS: Figure of merit (FOM) was compared using the jackknife alternative free-response receiver operating characteristics, and other per-lesion and per-patient diagnostic parameters for each image set were compared using McNemar's and Fisher's test. P < 0.05 was considered statistically significant. RESULTS: A total of 43 liver metastases were identified in 13 patients. Reader-averaged FOM to detect liver metastases were significantly higher for sets 2 (0.884) and 3 (0.886) than for set 1 (0.609), while they were comparable between sets 2 and 3 (P = 0.96). The mean per-patient sensitivities, negative predictive values, and accuracies were significantly higher for sets 2 and 3 than for set 1, while those between sets 2 and 3 were not significantly different (not applicable, P > 0.99, and P > 0.99, respectively). DATA CONCLUSION: Gadoxetic acid-enhanced MRI combined with CECT had higher diagnostic performance than CECT alone for the detection of liver metastases in patients with PDAC. The incremental values were comparable for the abbreviated MRI and standard MRI. LEVEL OF EVIDENCE: 3 TECHNICAL EFFICACY: Stage 2.

    2022年01月10日, Journal of magnetic resonance imaging : JMRI, 英語, 国際誌

    研究論文(学術雑誌)

  • Tomoko Aoki, Naoshi Nishida, Kazuomi Ueshima, Masahiro Morita, Hirokazu Chishina, Masahiro Takita, Satoru Hagiwara, Hiroshi Ida, Yasunori Minami, Akira Yamada, Keitaro Sofue, Masakatsu Tsurusaki, Masatoshi Kudo

    INTRODUCTION: Immune checkpoint inhibitors (ICIs) are promising agents for the treatment of hepatocellular carcinoma (HCC). However, the establishment of noninvasive measure that could predict the response to ICIs is challenging. This study aimed to evaluate tumor responses to ICIs using the hepatobiliary phase of gadolinium-ethoxybenzyl-diethylenetriamine (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI), which was shown to reflect Wnt/β-catenin activating mutation. METHODS: A total of 68 intrahepatic HCC nodules from 18 patients with unresectable HCC and Child-Pugh class A liver function who received anti-programmed cell death 1 (PD-1)/programmed death-ligand 1 (PD-L1) monotherapy were enrolled in this study. All patients had viable intrahepatic lesions evaluable using the hepatobiliary phase of Gd-EOB-DTPA-enhanced MRI within the 6 months prior to the treatment. The relative enhancement ratio was calculated, and the time to nodular progression (TTnP) defined as 20% or more increase in each nodule was compared between higher or hypo-enhancement HCC nodules. Then, the progression-free survival (PFS) and objective response rate (ORR) per Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST v1.1) were compared between patients with and without HCC nodules with higher enhancement on hepatobiliary phase images. RESULTS: The median PFS was 2.7 (95% confidence interval [CI]: 1.4-4.0) months in patients with HCC nodules with higher enhancement (n = 8) and 5.8 (95% CI: 0.0-18.9) months in patients with hypointense HCC nodules (n = 10) (p = 0.007). The median TTnP of HCC nodules with higher enhancement (n = 23) was 1.97 (95% CI: 1.86-2.07) months and that of hypointense HCC nodules (n = 45) was not reached (p = 0.003). The ORR was 12.5% (1/8) versus 30.0% (3/10); the disease control rate was 37.5% (3/8) versus 70.0% (7/10), respectively, in patients with or without higher enhancement intrahepatic HCC nodules. CONCLUSION: The TTnP on HCC nodules with higher enhancement and the median PFS in patients who carried higher enhancement intrahepatic HCC nodules were significantly shorter than those in hypointense HCC nodules with anti-PD-1/PD-L1 monotherapy. The intensity of the nodule on the hepatobiliary phase of Gd-EOB-DTPA-enhanced MRI is a promising imaging biomarker for predicting unfavorable response with anti-PD-1/PD-L1 monotherapy in patients with HCC.

    2021年11月, Liver cancer, 10 (6), 615 - 628, 英語, 国際誌

    研究論文(学術雑誌)

  • 島田 隆史, 祖父江 慶太郎, 上田 優, 谷 和紀子, 吉田 直碁, 堀井 慎太郎, 曽宮 雄一郎, 上野 嘉子, 日下 亜起子, 村上 卓道

    産業開発機構(株), 2021年12月, 映像情報Medical, 53 (14), 106 - 113, 日本語

  • The efficacy of pre-operative cine MRI to evaluate the adhesion of renal cancer thrombus to the wall of inferior vena cava(和訳中)

    植木 秀登, 寺川 智章, 上野 嘉子, 祖父江 慶太郎, 岡村 泰義, 原 琢人, 古川 順也, 原田 健一, 日向 信之, 中野 雄造, 藤澤 正人

    (一社)西日本泌尿器科学会, 2021年11月, 西日本泌尿器科学会総会抄録集, 73回, 166 - 166, 英語

  • 逆チャンス型胸椎骨折による血胸の一例

    松永 直樹, 岡田 卓也, 大野 雄康, 松代 啓吾, 佐々木 康二, 元津 倫幸, 上嶋 英介, 祖父江 慶太郎, 山口 雅人, 杉本 幸司, 村上 卓道

    (公社)日本医学放射線学会, 2021年08月, 日本医学放射線学会秋季臨床大会抄録集, 57回, S464 - S464, 日本語

  • 【ここまできた肝細胞癌の薬物療法:2021 update】免疫療法の動向 WNT/β-catenin変異のimaging biomarkerとしてのEOB-MRI

    青木 智子, 西田 直生志, 上嶋 一臣, 祖父江 慶太郎, 鶴崎 正勝, 工藤 正俊

    (株)アークメディア, 2021年08月, 肝胆膵, 83 (2), 209 - 218, 日本語

  • Shaggy aorta症例における上腸間膜動脈バルーンプロテクション併用下TEVARの有用性の検討

    佐々木 康二, 岡田 卓也, 山口 雅人, 田尻 昌士, Hamada Mostafa, 元津 倫幸, 上嶋 英介, 祖父江 慶太郎, 杉本 幸司, 村上 卓道

    (一社)日本インターベンショナルラジオロジー学会, 2021年04月, 日本インターベンショナルラジオロジー学会雑誌, 36 (Suppl.), 160 - 160, 日本語

  • 上顎癌動注化学療法における腫瘍進展方向と栄養血管に関する検討(Tumor extension and feeding arteries in intraarterial chemotherapy for maxillary cancer)

    Hamada Mostafa, 岡田 卓也, 山口 雅人, 佐々木 康二, 元津 倫幸, 上嶋 英介, 祖父江 慶太郎, 杉本 幸司, 村上 卓道

    (一社)日本インターベンショナルラジオロジー学会, 2021年04月, 日本インターベンショナルラジオロジー学会雑誌, 36 (Suppl.), 201 - 201, 英語

  • 陰部腟静脈瘤に対し血管内治療を行った1例

    田尻 昌士, 岡田 卓也, Ahmed Mostafa, 佐々木 康二, 元津 倫幸, 上嶋 英介, 祖父江 慶太郎, 山口 雅人, 杉本 幸司, 村上 卓道

    (一社)日本インターベンショナルラジオロジー学会, 2021年04月, 日本インターベンショナルラジオロジー学会雑誌, 36 (Suppl.), 251 - 251, 日本語

  • 【血管内治療における抗血栓療法】外傷性・医原性血管損傷に対するバイアバーン留置後の抗血栓療法

    岡田 卓也, 松代 啓吾, Hamada Mostafa, 佐々木 康二, 元津 倫幸, 上嶋 英介, 祖父江 慶太郎, 山口 雅人, 杉本 幸司, 村上 卓道

    外傷性・医原性血管損傷に対するバイアバーンステントグラフト留置後の抗血栓療法には定まった見解はなく、治療担当医の判断に委ねられている。浅大腿動脈の閉塞性疾患に対するバイアバーン留置後の抗血栓療法に準じた治療が行われることが多いが、治療血管の部位や再出血のリスクなどを鑑みて調整する必要がある。腹部分枝では、血管の蛇行や血管周囲の炎症や感染など、グラフト閉塞の原因となり得る因子がある一方で、必ずしも長期開存が求められない場合もある。腸骨動脈では、グラフト閉塞の可能性は基本的に低いと思われるため、場合によっては抗血栓療法を行わないのも一つの選択肢である。反対に、鎖骨下動脈では確実な開存性を担保したい場合が多く、抗血栓療法は必須と考える。外傷性・医原性出血に対するバイアバーンステントグラフトの長期成績はいまだ不明であり、さらなるエビデンスの構築が望まれる。(著者抄録)

    (一社)日本血管内治療学会, 2021年, 日本血管内治療学会誌, 22 (1), 50 - 53, 日本語

  • 【血管内治療における抗血栓療法】外傷性・医原性血管損傷に対するバイアバーン留置後の抗血栓療法

    岡田 卓也, 松代 啓吾, Hamada Mostafa, 佐々木 康二, 元津 倫幸, 上嶋 英介, 祖父江 慶太郎, 山口 雅人, 杉本 幸司, 村上 卓道

    (一社)日本血管内治療学会, 2021年, 日本血管内治療学会誌, 22 (1), 50 - 53, 日本語

  • Timo A Auer, Keitaro Sofue, Eisuke Ueshima, Nina Rauer, Takeru Yamaguchi, Bernhard Gebauer, Bernd Hamm, Takamichi Murakami, Christian Althoff

    Informa UK Limited, 2022年08月, Journal of Hepatocellular Carcinoma, Volume 9, 695 - 705

    研究論文(学術雑誌)

MISC

  • 上嶋 英介, 祖父江 慶太郎, 村上 卓道

    肝内胆管癌は、発育形態により腫瘤形成型、胆管浸潤型、胆管内発育型の三つのタイプに分類される一方で、組織学的には由来となる胆管レベルにより分類される。2019年に発刊された最新のWHO分類第5版では、large duct type、small duct typeの二つのタイプに分類され、本邦の肝癌取扱い規約において単独の疾患として扱われる細胆管癌はsmall duct typeに含まれるようになった。各タイプにより組織学的特徴や予後が異なり、CTやMRIなどの診断モダリティーによる画像所見も異なる。それぞれに特徴的な所見、他疾患との鑑別に注意を要すべき所見もあり、これらについて概説する。また、肝内胆管癌の前癌病変に位置付けられる胆管内乳頭状腫瘍、肝粘液性嚢胞性腫瘍の画像所見についても併せて述べる。(著者抄録)

    医学図書出版(株), 2021年09月, 胆と膵, 42 (9), 815 - 822, 日本語

  • 【ここまできた肝細胞癌の薬物療法:2021 update】免疫療法の動向 WNT/β-catenin変異のimaging biomarkerとしてのEOB-MRI

    青木 智子, 西田 直生志, 上嶋 一臣, 祖父江 慶太郎, 鶴崎 正勝, 工藤 正俊

    Gadolinium-ethoxybenzyl-diethylenetriamine(Gd-EOB-DTPA)-enhanced MRI(EOB-MRI)の肝細胞相を用いることで免疫チェックポイント阻害剤の治療抵抗性を非侵襲的に予測可能かどうか検討した。当施設で全身化学療法を施行した切除不能肝細胞癌症例18例(男性13例、女性5例、中央値69歳)を対象とした。全患者における抗PD-1/PD-L1単独療法開始からの無増悪生存期間(PFS)中央値は4.23ヵ月、全生存期間中央値は26.3ヵ月であった。奏効率はCR 0%、PR 22.2%、SD 33.3%、PD 44.4%で、ORR 22.2%、DCR 55.6%であった。Child-Pugh class Aの肝機能を有する切除不能肝細胞癌にとって、EOB-MRI肝細胞相における信号強度はPD-1/PD-L1単独療法に対する治療抵抗性を予測する非侵襲的で有用なバイオマーカーである。

    (株)アークメディア, 2021年08月, 肝胆膵, 83 (2), 209 - 218, 日本語

  • 上嶋 英介, 祖父江 慶太郎, 村上 卓道

    (一社)日本肝臓学会, 2021年05月, 肝臓, 62 (5), 229 - 239, 日本語

  • 上野 嘉子, 浦瀬 靖代, 祖父江 慶太郎, 村上 卓道

    <文献概要>腎泌尿器領域の正常変異,奇形,腫瘍類似病変を中心に,代表的な画像と診断のポイントについて概説する。

    (株)メジカルビュー社, 2021年04月, 臨床画像, 37 (4月増刊), 128 - 150, 日本語

  • 祖父江 慶太郎, 上嶋 英介, 村上 卓道, 矢部 慎二, 辻田 有志, 山口 尊, 上野 嘉子, 堀 雅敏

    <文献概要>本特別企画に選出いただいたテーマは,第56回日本医学放射線学会秋季臨床大会で講演した内容である。肝細胞癌診断における造影CTの位置付けとその画像所見の成り立ち,診断能向上における最近の研究についてまとめたものであり,主に放射線科診断専門医資格取得前後の若い先生方を対象とした内容となっている。

    (株)メジカルビュー社, 2021年04月, 臨床画像, 37 (4), 490 - 497, 日本語

  • 浦瀬 靖代, 上野 嘉子, 祖父江 慶太郎, 村上 卓道, 宇野 礼奈, 今岡 いずみ

    <文献概要>日常臨床でみられる頻度の高い卵巣腫瘍である内膜症性嚢胞および成熟奇形腫,さらに産婦人科救急疾患の1つである卵巣茎捻転について取り上げた。これらの疾患を診断するうえでのポイントおよびピットフォールを中心に述べる。

    (株)メジカルビュー社, 2021年02月, 臨床画像, 37 (2), 230 - 244, 日本語

  • 上野 嘉子, 浦瀬 靖代, 祖父江 慶太郎, 村上 卓道

    <文献概要>立腺MRIの役割は,(1)臨床的有意癌(clinically significant cancer)の検出と部位の特定,(2)病期診断,に大きく分けられる。生検前であれば生検適応や標的生検部位の決定に必要な情報が求められる。生検後であれば病期診断に必要な情報に加え,系統的生検でヒットしていなかった部位の病変をMRIで検出することもある。本稿では2019年に改訂されたProstate Imaging and Reporting and Data System(PI-RADS) v2.1(https://www.acr.org/Quality-Safety/Resources/PI-RADS)の内容を踏まえ,診断レポートに記載すべき項目について考察する。なお臨床的有意癌の検出,病期診断いずれにおいても解剖学的情報,形態学的な評価を目的としたT1,T2強調像と,機能画像である拡散強調像,dynamic MRIを組み合わせたmultiparametric-MRI(mp-MRI)による評価が望ましい。

    (株)メジカルビュー社, 2021年01月, 臨床画像, 37 (1), 140 - 147, 日本語

  • CT or MRI CT、MRIどっちを依頼?(No.10) 肝 超音波検査で肝に腫瘤が疑われた

    祖父江 慶太郎, 村上 卓道

    (公社)日本医師会, 2021年01月, 日本医師会雑誌, 149 (10), 1808 - 1809, 日本語

  • 【マネジメントに苦慮する疾患:Is it benign,malignant or insignificant?】前立腺clinically insignificant cancerの診断とマネジメントにおけるMRIの役割

    上野 嘉子, 玉田 勉, 浦瀬 靖代, 祖父江 慶太郎, 高橋 哲, 村上 卓道

    バイエル薬品(株), 2020年12月, 日独医報, 65 (1), 55 - 63, 日本語

  • 谷川 昇, 曽根 美雪, 大内 泰文, 米虫 敦, 坂本 憲昭, 塩山 靖和, 祖父江 慶太郎, 中島 康雄, 野口 智幸, 橋本 政幸, 保本 卓, 矢田 晋作, 山本 晃, 鈴木 耕次郎, 小林 飛鳥, 松岡 利幸, 梛野 正人, 日本インターベンショナルラジオロジー学会ガイドライン委員会

    (一社)日本インターベンショナルラジオロジー学会, 2020年11月, 日本インターベンショナルラジオロジー学会雑誌, 35 (2), 184 - 193, 日本語

  • 上野 嘉子, 今岡 いずみ, 浦瀬 靖代, 神田 知紀, 祖父江 慶太郎, 堀 雅敏, 村上 卓道

    <文献概要>子宮内膜癌におけるMRIの役割は主に病期診断である.重要な再発リスク因子である深部筋層浸潤の評価には,従来,T2強調像とダイナミックMRIが用いられてきたが,近年では拡散強調像の有用性も多数報告されている.治療方針の決定においてMRIは重要な役割を果たすが,そのピットフォールや限界についても知る必要がある.

    (株)学研メディカル秀潤社, 2020年10月, 画像診断, 40 (13), 1299 - 1310, 日本語

  • 骨転移疼痛に対する集学的治療 -この痛みをどう治療するか- 骨転移に対する骨セメント治療 経皮的椎体形成術の適応を考える

    岡田 卓也, 佐々木 康二, Hamada M.A.S., 元津 倫幸, 上嶋 英介, 祖父江 慶太郎, 山口 雅人, 杉本 幸司, 村上 卓道

    (一社)日本インターベンショナルラジオロジー学会, 2020年08月, 日本インターベンショナルラジオロジー学会雑誌, 35 (Suppl.), 131 - 131, 日本語

  • 【特集】Precision Medicine時代のAbdominal Imaging 2020【後編】:Ⅳ CT:腹部領域における技術の到達点と臨床の最前線:1.CTの技術進歩で変わる臨床の今と未来:4)CTによる肝脂肪定量・肝線維化推定の実際と今後の展望

    山口 尊, 祖父江慶太郎, 村上卓道

    2020年05月, Innervision, 35 (5), 14 - 16

  • 浦瀬 靖代, 上野 嘉子, 神田 知紀, 祖父江 慶太郎, 小川 悟史, 稲場 礼奈, 神保 直江, 村上 卓道

    症例は30歳代男性で、神経線維腫症1型(NF1)で通院中であった。MRIで偶発的に膀胱腫瘤を指摘された。NF1を背景にもち、MRIでの特徴的な信号パターンおよび膀胱鏡で粘膜下腫瘤であったことから、神経線維腫を疑った。根治的切除となると尿路変更術を必要とし、症状がない現状では過大な侵襲であり、かつ切除断端から再発する可能性が高いと考えられ、神経線維腫の診断確定およびmalignant peripheral nerve sheath tumor(MPNST)の除外目的に、三角部の腫瘤よりTUR-BTを施行した。膀胱三角部の腫瘤は容易に切除可能であり、出血もほとんどみられなかった。摘出された腫瘤の組織像では、myxoidな成分を伴う粗な短紡錘形細胞の走行を認め、配列は粗であった。末梢神経に巻き付くように進展する形態を示す部位もみられた。MPNSTを疑うような細胞の異型性はみられなかった。以上より、蔓状神経線維腫と診断された。

    金原出版(株), 2020年05月, 臨床放射線, 65 (5), 487 - 490, 日本語

  • 島田 隆史, 祖父江 慶太郎, 野田 知寛, 上田 優, 堀井 慎太郎, 曽宮 雄一郎, 勝又 康友, 日下 亜起子, 村上 卓道

    上腹部における造影MRI検査では、2008年1月よりガドキセト酸ナトリウム(gadoxetic acid disodium:EOB)の臨床使用が開始されてから、肝臓MRI検査の診断能が大きく向上したのは周知の事実である。しかし、臨床的には注入時間が短いことに起因する撮像タイミングの課題や、動脈相における呼吸性アーチファクト(transient severe motion artifact:TSM)などの問題も確認され、さまざまな対策が試みられている。本稿では、その両者を解決できる可能性のある"4D FreeBreathing"(フィリップス社)が当院に導入されたので、初期経験と問題点を含めて概説する。(著者抄録)

    (株)インナービジョン, 2020年03月, INNERVISION, 35 (4), 21 - 24, 日本語

  • 当院における脾動脈瘤に対する動脈塞栓術の治療成績

    岡田 卓也, 佐々木 康二, Hamada Mostafa, 堀之内 宏樹, 元津 倫幸, 上嶋 英介, 祖父江 慶太郎, 山口 雅人, 杉本 幸司, 村上 卓道

    (一社)日本脈管学会, 2019年10月, 脈管学, 59 (Suppl.), S140 - S140, 日本語

  • Iliac Branch Endoprosthesisを用いたステントグラフト内挿術の初期成績

    元津 倫幸, 山口 雅人, Hamada Mostafa, 佐々木 康二, 堀之内 宏樹, 上嶋 英介, 岡田 卓也, 祖父江 慶太郎, 後竹 康子, 中井 秀和, 山中 勝弘, 大村 篤史, 岡田 健次, 杉本 幸司, 村上 卓道

    (一社)日本脈管学会, 2019年10月, 脈管学, 59 (Suppl.), S175 - S175, 日本語

  • 気管内挿管後に舌壊死を来した1例

    浦瀬 靖代, 神田 知紀, 小路田 泰之, 上野 嘉子, 祖父江 慶太郎, 前田 隆樹, 野上 宗伸, 村上 卓道

    (公社)日本医学放射線学会, 2019年09月, 日本医学放射線学会秋季臨床大会抄録集, 55回, S558 - S558, 日本語

  • 直腸静脈瘤に対して上直腸静脈直接穿刺法で塞栓術を行った1例

    元津 倫幸, 岡田 卓也, 小出 裕, 佐々木 康二, Hamada M.A.S., 堀之内 宏樹, 谷 龍一郎, 上嶋 英介, 祖父江 慶太郎, 山口 雅人, 杉本 幸司, 村上 卓道

    (一社)日本インターベンショナルラジオロジー学会, 2019年09月, 日本インターベンショナルラジオロジー学会雑誌, 34 (1), 79 - 79, 日本語

  • 気管内挿管後に舌壊死を来した1例

    浦瀬 靖代, 神田 知紀, 小路田 泰之, 上野 嘉子, 祖父江 慶太郎, 前田 隆樹, 野上 宗伸, 村上 卓道

    (公社)日本医学放射線学会, 2019年09月, 日本医学放射線学会秋季臨床大会抄録集, 55回, S558 - S558, 日本語

  • 肝細胞癌に対する放射線照射治療後の経動脈的化学塞栓療法の安全性の検討

    小出 裕, ムスタファ・ハマダ, 上嶋 英介, 堀之内 宏樹, 佐々木 康二, 元津 倫幸, 谷 龍一郎, 岡田 卓也, 祖父江 慶太郎, 山口 雅人, 石田 淳, 石原 武明, 佐々木 良平, 杉本 幸司, 村上 卓道

    (一社)日本インターベンショナルラジオロジー学会, 2019年05月, 日本インターベンショナルラジオロジー学会雑誌, 34 (Suppl.), 226 - 226, 日本語

  • 当院における経腟分娩後の産道出血に対する動脈塞栓術の検討

    佐々木 康二, 岡田 卓也, HAMADA MOSTAFA, 堀之内 宏樹, 元津 倫幸, 谷 龍一郎, 上嶋 英介, 小出 裕, 祖父江 慶太郎, 山口 雅人, 杉本 幸司, 村上 卓道

    (一社)日本インターベンショナルラジオロジー学会, 2019年05月, 日本インターベンショナルラジオロジー学会雑誌, 34 (Suppl.), 239 - 239, 日本語

  • Iliac Branch Endoprosthesisを用いたステントグラフト内挿術の初期成績

    元津 倫幸, 山口 雅人, 佐々木 康二, 堀之内 宏樹, 谷 龍一郎, 上嶋 英介, 小出 裕, 岡田 卓也, 祖父江 慶太郎, 後竹 康子, 中井 秀和, 山中 勝弘, 岡田 健次, 杉本 幸司, 村上 卓道

    (一社)日本インターベンショナルラジオロジー学会, 2019年05月, 日本インターベンショナルラジオロジー学会雑誌, 34 (Suppl.), 255 - 255, 日本語

  • 当院における大動脈解離に対するTEVARの治療成績

    岡田 卓也, 山口 雅人, 佐々木 康二, 堀之内 宏樹, 元津 倫幸, 谷 龍一郎, 上嶋 英介, 小出 裕, 祖父江 慶太郎, 後竹 康子, 中井 秀和, 山中 勝弘, 岡田 健次, 杉本 幸司, 村上 卓道

    (一社)日本インターベンショナルラジオロジー学会, 2019年05月, 日本インターベンショナルラジオロジー学会雑誌, 34 (Suppl.), 259 - 259, 日本語

  • CTで認識できない骨病変に対するCTガイド下骨生検の検討

    谷 龍一郎, 岡田 卓也, 佐々木 康二, HAMADA MOSTAFA, 堀之内 宏樹, 元津 倫幸, 上嶋 英介, 小出 裕, 祖父江 慶太郎, 山口 雅人, 杉本 幸司, 村上 卓道

    (一社)日本インターベンショナルラジオロジー学会, 2019年05月, 日本インターベンショナルラジオロジー学会雑誌, 34 (Suppl.), 314 - 314, 日本語

  • 肝細胞癌に対する放射線照射治療後の経動脈的化学塞栓療法の安全性の検討

    小出 裕, ムスタファ・ハマダ, 上嶋 英介, 堀之内 宏樹, 佐々木 康二, 元津 倫幸, 谷 龍一郎, 岡田 卓也, 祖父江 慶太郎, 山口 雅人, 石田 淳, 石原 武明, 佐々木 良平, 杉本 幸司, 村上 卓道

    (一社)日本インターベンショナルラジオロジー学会, 2019年05月, 日本インターベンショナルラジオロジー学会雑誌, 34 (Suppl.), 226 - 226, 日本語

  • 血管塞栓術に用いるNBCAのガイドライン2012

    竹内 義人, 坂本 憲昭, 佐藤 洋造, 祖父江 慶太郎, 徳江 浩之, 濱口 真吾, 藤原 寛康, 村上 健司, 森下 博之, 米満 尚史, 池田 裕隆, 生駒 顕, 井戸口 孝二, 井上 大作, 井原 弘貴, 宇賀 麻由, 岡田 卓也, 小川 普久, 奥野 晃章, 加藤 洋, 加藤 弥菜, 栗延 孝至, 粉川 怜子, 米虫 敦, 佐藤 健司, 柴田 尚明, 芝 奈津子, 芝本 健太郎, 菅原 俊祐, 田村 全, 田村 泰治, 冨田 晃司, 正岡 佳久, 八木 理恵, 吉松 美佐子, 滝澤 謙治, 佐口 徹, 竹内 義人, 宮山 士朗, 安陪 等思, 東原 秀行, 佐藤 守男, 中島 康雄, 大須賀 慶悟, 金澤 右, 加山 英夫, 興梠 征典, 後藤 靖雄, 塩山 靖和, 曽根 美雪, 鶴崎 正勝, 成松 芳明, 西巻 博, 三村 秀文, 日本IVR学会, 血管塞栓術に用いるNBCAのガイドライン2012ガイドライン作成委員会, 血管塞栓術に用いるNBCAのガイドライン作成委員会, 血管内使用禁忌とされる塞栓物質の使用ガイドライン作成小委員会, 血管塞栓術に用いるNBCAのガイドライン2012ガイドライン評価委員会, 日本IVR学会ガイドライン委員会

    (一社)日本インターベンショナルラジオロジー学会, 2019年04月, 日本インターベンショナルラジオロジー学会雑誌, 33 (4), 427 - 444, 日本語

  • 肝外傷に対するIVRのガイドライン2016

    米虫 敦, 坂本 憲昭, 谷川 昇, 曽根 美雪, 大内 泰文, 後藤 靖雄, 塩山 靖和, 祖父江 慶太郎, 中島 康雄, 野口 智幸, 橋本 政幸, 保本 卓, 矢田 晋作, 大友 康裕, 渡部 広明, 西巻 博, 樫見 文枝, 田島 廣之, 萩原 章嘉, 服部 貴行, 嶺 貴彦, 船曳 知弘, 山下 寛高, 金沢 右, 大須賀 慶悟, 加山 英夫, 興梠 征典, 鶴崎 正勝, 成松 芳明, 三村 秀文, 伊藤 憲佐, 日本IVR学会, 肝外傷に対するIVRのガイドライ, ガイドライン作成, 改訂委員会, 肝外傷に対するIVRのガイドライン作成, 改訂委員会, 日本IVR学会ガイドライン委員会, 肝外傷に対するIVRのガイドライ, ガイドライン評価委員会, 日本外傷学会, 肝外傷に対するIVRのガイドライ, ガイドライン作成委員会, 肝外傷に対するIVRのガイドライン作成委員会, 肝外傷に対するIVRのガイドライ, ガイドライン評価委員会

    (一社)日本インターベンショナルラジオロジー学会, 2019年04月, 日本インターベンショナルラジオロジー学会雑誌, 33 (4), 472 - 484, 日本語

  • 静脈洞血栓をきたしたRendu‐Osler‐Weber病の一例

    神田知紀, 宮崎亜紀, 曽菲比, 上野嘉子, 祖父江慶太郎, 前田隆樹, 野上宗伸, 村上卓道

    2019年, 日本神経放射線学会プログラム・抄録集, 48th, 101, 日本語

  • 当院における脾動脈瘤に対する動脈塞栓術の治療成績

    岡田卓也, 佐々木康二, HAMADA Mostafa, 堀之内宏樹, 元津倫幸, 上嶋英介, 祖父江慶太郎, 山口雅人, 杉本幸司, 村上卓道

    2019年, 脈管学(Web), 59 (supplement)

  • Iliac Branch Endoprosthesisを用いたステントグラフト内挿術の初期成績

    元津倫幸, 山口雅人, HAMADA Mostafa, 佐々木康二, 堀之内宏樹, 上嶋英介, 岡田卓也, 祖父江慶太郎, 後竹康子, 中井秀和, 山中勝弘, 大村篤史, 岡田健次, 杉本幸司, 村上卓道

    2019年, 脈管学(Web), 59 (supplement)

  • 直腸静脈瘤に対して上直腸静脈直接穿刺法で塞栓術を行った1例

    元津倫幸, 岡田卓也, 小出裕, 佐々木康二, HAMADA M.A.S., 堀之内宏樹, 谷龍一郎, 上嶋英介, 祖父江慶太郎, 山口雅人, 杉本幸司, 村上卓道

    2019年, 日本インターベンショナルラジオロジー学会雑誌(Web), 34 (1)

  • 前立腺移行域癌診断におけるQuantitative Multiparametric MRIの有用性

    浦瀬靖代, 上野嘉子, 祖父江慶太郎, 堀井慎太郎, 京谷勉輔, 田中宇多留, 板東由加里, 日向信之, 藤澤正人, 上原慶一郎, 高橋哲, 村上卓道

    2019年, 泌尿器画像診断・治療技術研究会プログラム・抄録, 7th

  • 破裂性十二指腸静脈瘤に対してバルーン閉塞下逆行性静脈瘤塞栓術を施行した1例

    小出 裕, 岡田 卓也, 佐々木 康二, 元津 倫幸, Hamada M.A.S., 谷 龍一郎, 上嶋 英介, 祖父江 慶太郎, 山口 雅人, 杉本 幸司, 村上 卓道

    (一社)日本インターベンショナルラジオロジー学会, 2018年11月, IVR: Interventional Radiology, 33 (3), 317 - 318, 日本語

  • 【救急IVR手技詳説 with WEB動画】手技詳説 非血管IVR 画像ガイド下穿刺 超音波ガイド下穿刺

    祖父江 慶太郎, 山口 雅人, 杉本 幸司, 村上 卓道

    金原出版(株), 2018年11月, 臨床放射線, 63 (12), 1582 - 1585, 日本語

    [招待有り]

    記事・総説・解説・論説等(学術雑誌)

  • FDG PET/MRにおける呼吸同期下MR吸収補正と画像再構成法の影響

    野上 宗伸, 曽 菲比, 若林 雄一, 上野 嘉子, 神田 知紀, 祖父江 慶太郎, 栗本 貴子, 久保 和広, 村上 卓道

    (一社)日本核医学会, 2018年11月, 核医学, 55 (Suppl.), S209 - S209, 英語

  • 中長期成績からみた腹部大動脈瘤ステントグラフトの功罪 IMA閉塞例におけるEVAR後のType 2エンドリークの検討 予防的IMA塞栓術は有用か?

    岡田 卓也, 元津 倫幸, 山口 雅人, 佐々木 康二, Hamada Mostafa, 谷 龍一郎, 上嶋 英介, 小出 裕, 祖父江 慶太郎, 杉本 幸司, 村上 卓道, 後竹 康子, 中井 秀和, 山中 勝弘, 田中 裕史

    (一社)日本脈管学会, 2018年09月, 脈管学, 58 (Suppl.), S107 - S107, 日本語

  • 翼口蓋窩に生じた筋上皮腫の1例

    立花 美保, 神田 知紀, 田中 宇多留, 上野 嘉子, 祖父江 慶太郎, 前田 隆樹, 野上 宗伸, 村上 卓道, 神澤 真紀, 伊藤 智雄

    (公社)日本医学放射線学会, 2018年09月, 日本医学放射線学会秋季臨床大会抄録集, 54回, S536 - S536, 日本語

  • IVRの進歩がどのように門脈圧亢進症の治療を変えたのか? 肝細胞癌門脈腫瘍栓に対するEMS留置術

    鶴崎 正勝, 沼本 勲男, 小田 晃義, 門場 智也, 柳生 行伸, 祖父江 慶太郎, 杉本 幸司, 村上 卓道

    (一社)日本門脈圧亢進症学会, 2018年08月, 日本門脈圧亢進症学会雑誌, 24 (3), 86 - 86, 日本語

  • IMA閉塞例におけるEVAR後のType2エンドリークの検討:予防的IMA塞栓術は有用か?

    岡田卓也, 元津倫幸, 山口雅人, 佐々木康二, HAMADA Mostafa, 谷龍一郎, 上嶋英介, 小出裕, 祖父江慶太郎, 杉本幸司, 村上卓道, 後竹康子, 中井秀和, 山中勝弘, 田中裕史

    2018年, 脈管学(Web), 58 (supplement)

  • Kazuhiro Kitajima, Masatoyo Nakajo, Hayato Kaida, Ryogo Minamimoto, Kenji Hirata, Masakatsu Tsurusaki, Hiroshi Doi, Yoshiko Ueno, Keitaro Sofue, Yukihisa Tamaki, Koichiro Yamakado

    Positron emission tomography/computed tomography (PET/CT) integrated with 2-[F-18] fluoro-2-deoxy-D-glucose (FDG) is a useful tool for acquisition of both glucose metabolism and anatomic imaging data, as only a single device and one diagnostic session is required, thus opening a new field in clinical oncologic imaging. FDG-PET/CT has been successfully used for initial staging, restaging, assessment of early treatment response, evaluation of metastatic disease response, and prognostication of intestinal cancer as well as various malignant tumors. We reviewed the current status and role of FDG-PET/CT for management of patients with esophageal cancer, gastric cancer, and colorectal cancer, with focus on both its usefulness and limitations.

    NAGOYA UNIV, SCH MED, 2017年11月, NAGOYA JOURNAL OF MEDICAL SCIENCE, 79 (4), 527 - 543, 英語

    書評論文,書評,文献紹介等

  • 【肝癌診療A to Z】 肝癌画像診断のアップデート CT、MRI

    鶴崎正勝, 祖父江慶太郎, 村上卓道

    2017年10月, 肝臓クリニカルアップデート, 3 (2号), 115 - 120, 日本語

    [招待有り]

    記事・総説・解説・論説等(学術雑誌)

  • F-18 FDG PET/MRを用いた消化管の生理的集積に関する検討 FDG集積とMRI信号との対比

    野上 宗伸, 下山 真介, 若林 雄一, 田中 宇多留, 上野 嘉子, 祖父江 慶太郎, 久保 和広, 高橋 哲

    (一社)日本核医学会, 2017年09月, 核医学, 54 (Suppl.), S193 - S193, 日本語

  • 空腸動脈瘤の塞栓術後に正中弓状靭帯の圧迫による副駆動脈起始部狭窄に対してステントを留置した1例

    元津倫幸, 岡田卓也, 谷龍一郎, 片山直人, 上嶋英介, 小出裕, 祖父江慶太郎, 山口雅人, 野村佳克, 大北裕, 杉本幸司

    2017年07月, Metallic Stentの現状と進歩XVII, 32, 20 - 21, 日本語

    [招待有り]

    速報,短報,研究ノート等(学術雑誌)

  • Integrated FDG-PET/MRI for whole-body staging in patients with recurrent gynecological cancer

    Kazuhiro Kitajima, Munenobu Nogami, Satoru Takahashi, Yoshiko Ueno, Yasuhiko Ebina, Kazuhiro Kubo, Utaru Tanaka, Keitaro Sofue, Takeaki Ishihara, Yuichi Wakabayashi, Kazunari Ishii, Kazuro Sugimura

    SOC NUCLEAR MEDICINE INC, 2017年05月, JOURNAL OF NUCLEAR MEDICINE, 58, 英語

    研究発表ペーパー・要旨(国際会議)

  • 祖父江 慶太郎, 村上 卓道, 鶴崎 正勝, 山口 雅人, 杉本 幸司, 杉村 和朗

    金原出版(株), 2017年04月, 臨床放射線, 62 (4), 497 - 505, 日本語

    [招待有り]

    記事・総説・解説・論説等(商業誌、新聞、ウェブメディア)

  • IVR技術のいろは 超音波ガイド下穿刺技術のいろは

    祖父江 慶太郎, 片山 直人, 岡田 卓也, 山口 雅人, 杉本 幸司

    (一社)日本インターベンショナルラジオロジー学会, 2017年04月, IVR: Interventional Radiology, 32 (Suppl.), 129 - 129, 日本語

  • 腫瘍性脊椎圧骨折に対する経皮的椎体形成術の検討

    谷 龍一郎, 岡田 卓也, 丸山 晃司, 堀之内 宏樹, 臼井 亮介, 元津 倫幸, 片山 直人, 上嶋 英介, 小出 裕, 祖父江 慶太郎, 山口 雅人, 杉本 幸司

    (一社)日本インターベンショナルラジオロジー学会, 2017年04月, IVR: Interventional Radiology, 32 (Suppl.), 164 - 164, 日本語

  • 動脈塞栓術を施行した腎部分切除術後の仮性動脈瘤の検討

    臼井 亮介, 岡田 卓也, 丸山 晃司, 堀之内 宏樹, 元津 倫幸, 谷 龍一郎, 片山 直人, 上嶋 英介, 小出 裕, 祖父江 慶太郎, 山口 雅人, 杉本 幸司

    (一社)日本インターベンショナルラジオロジー学会, 2017年04月, IVR: Interventional Radiology, 32 (Suppl.), 180 - 180, 日本語

  • 十二指腸静脈瘤に対するB-RTOの有効性の検討

    丸山 晃司, 岡田 卓也, 堀之内 宏樹, 元津 倫幸, 谷 龍一郎, 片山 直人, 上嶋 英介, 小出 裕, 祖父江 慶太郎, 山口 雅人, 杉本 幸司

    (一社)日本インターベンショナルラジオロジー学会, 2017年04月, IVR: Interventional Radiology, 32 (Suppl.), 236 - 236, 日本語

  • 祖父江 慶太郎, 鶴崎 正勝, 村上 卓道, 丸山 晃司, 元津 倫幸, 谷 龍一郎, 片山 直人, 上嶋 栄介, 岡田 卓也, 山口 雅人, 杉本 幸司, 杉村 和朗

    金原出版(株), 2016年11月, 臨床放射線, 61 (11), 1439 - 1443, 日本語

    [査読有り]

    記事・総説・解説・論説等(学術雑誌)

  • Achille Mileto, Keitaro Sofue, Daniele Marin

    Many fortuitously detected renal lesions are incompletely characterised at traditional MDCT imaging, thus posing daily challenges to radiologists and referring physicians. There is burgeoning evidence that dual-energy MDCT and multi-energy applications provide an added value over traditional MDCT imaging in renal lesion characterisation and throughput. This special report gives a vendor-neutral outlook on technical essentials, recommended protocols, high-yield clinical opportunities and reviews radiation dose aspects of dual-energy MDCT imaging and multi-energy applications in renal lesions. In addition to a guide on interpretative traps and emerging problems, we provide an update on new, potential imaging horizons. Dual-energy MDCT and multi-energy applications can facilitate the imaging interpretation and throughput of renal lesions. Conjointly with capitalisation on the benefits, familiarity with dual- and multi-energy data sets as well as continuous scrutiny of interpretative traps can be the keys to the successful implementation and enhanced clinical acceptance of this powerful technique in the imaging community. Continuous advances in hardware and computer interfaces are expected to pave the way for the further expansion of the application spectrum. aEuro cent Optimal protocols must be adopted for leveraging dual-energy benefits in renal imaging. aEuro cent Virtual monochromatic imaging can overcome renal cyst pseudoenhancement. aEuro cent Iodine maps help to interpret renal lesions incompletely characterised at traditional MDCT. aEuro cent Interpretative traps need to be weighed-up in dual-energy renal lesions imaging. aEuro cent Technical advances are expanding the dual-energy applications spectrum for renal lesions imaging.

    SPRINGER, 2016年10月, EUROPEAN RADIOLOGY, 26 (10), 3677 - 3690, 英語, 国際誌

    [査読有り]

  • EVAR後の遅発性type 1bエンドリークの危険因子に関する検討

    元津 倫幸, 岡田 卓也, 丸山 晃司, 堀之内 宏樹, 臼井 亮介, 片山 直人, 後竹 康子, 谷 龍一郎, 上嶋 英介, 小出 裕, 野村 佳克, 祖父江 慶太郎, 山口 雅人, 大北 裕, 杉本 幸司

    (一社)日本脈管学会, 2016年10月, 脈管学, 56 (Suppl.), S137 - S137, 日本語

  • 左総腸骨動脈閉塞を伴う腹部大動脈瘤に対するEVAR後にTypell endoleak塞栓を繰り返した1例

    堀之内 宏樹, 山口 雅人, 丸山 晃司, 臼井 亮介, 元津 倫幸, 谷 龍一郎, 片山 直人, 上嶋 英介, 小出 裕, 岡田 卓也, 祖父江 慶太郎, 後竹 康子, 野村 佳克, 大北 裕, 杉本 幸司

    (一社)日本脈管学会, 2016年10月, 脈管学, 56 (Suppl.), S188 - S189, 日本語

  • 上腸間膜動脈急性閉塞に対しフォガティースルールーメンカテーテルを用いて血栓除去を行った一例

    谷 龍一郎, 山口 雅人, 臼井 亮介, 丸山 晃司, 堀之内 宏樹, 元津 倫幸, 片山 直人, 上嶋 英介, 小出 裕, 岡田 卓也, 祖父江 慶太郎, 杉本 幸司, 野村 佳克, 後竹 康子, 大北 裕

    (一社)日本脈管学会, 2016年10月, 脈管学, 56 (Suppl.), S207 - S207, 日本語

  • ハイブリッド手術システムを用いたIVR 非大血管疾患における臨床応用

    岡田 卓也, 山口 雅人, 臼井 亮介, 丸山 晃司, 堀之内 宏樹, 元津 倫幸, 谷 龍一郎, 片山 直人, 上嶋 英介, 小出 裕, 祖父江 慶太郎, 杉本 幸司

    (一社)日本インターベンショナルラジオロジー学会, 2016年08月, IVR: Interventional Radiology, 31 (3), 266 - 266, 日本語

  • 左総腸骨動脈閉塞を伴う腹部大動脈瘤に対するEVAR後にType II endoleak塞栓を繰り返した1例

    堀之内 宏樹, 山口 雅人, 丸山 晃司, 臼井 亮介, 元津 倫幸, 谷 龍一郎, 片山 直人, 上嶋 英介, 小出 裕, 岡田 卓也, 祖父江 慶太郎, 杉本 幸司, 後竹 康子, 野村 佳克, 大北 裕

    (一社)日本インターベンショナルラジオロジー学会, 2016年08月, IVR: Interventional Radiology, 31 (3), 267 - 267, 日本語

  • 山口 雅人, 岡田 卓也, 上嶋 英介, 祖父江 慶太郎, 小出 裕, 片山 直人, 元津 倫幸, 谷 龍一郎, 杉本 幸司

    (一社)日本インターベンショナルラジオロジー学会, 2016年06月, IVR: Interventional Radiology, 31 (2), 129 - 135, 日本語

    [査読有り][招待有り]

    記事・総説・解説・論説等(学術雑誌)

  • 予防的IMA塞栓術を施行したENDURANT Stentgraft Systemを用いたEVARの治療成績

    片山 直人, 岡田 卓也, 元津 倫幸, 谷 龍一郎, 上嶋 英介, 小出 裕, 祖父江 慶太郎, 山口 雅人, 杉本 幸司, 後竹 康子, 野村 佳克, 大北 裕

    (一社)日本インターベンショナルラジオロジー学会, 2016年06月, IVR: Interventional Radiology, 31 (2), 178 - 178, 日本語

  • EVAR後の遅発性Type 1a endoleakに対し瘤内塞栓術およびAortic cuff留置術にて治療した1例

    小出 裕, 岡田 卓也, 元津 倫幸, 谷 龍一郎, 片山 直人, 上嶋 英介, 祖父江 慶太郎, 山口 雅人, 杉本 幸司, 後竹 康子, 野村 佳克, 大北 裕

    (一社)日本インターベンショナルラジオロジー学会, 2016年06月, IVR: Interventional Radiology, 31 (2), 178 - 178, 日本語

  • 大動脈・末梢動脈疾患に対する救急IVR 神戸大学病院における取り組みとその応用

    山口 雅人, 元津 倫幸, 谷 龍一郎, 片山 直人, 上嶋 英介, 小出 裕, 岡田 卓也, 祖父江 慶太郎, 杉本 幸司, 後竹 康子, 野村 佳克, 大北 裕

    (一社)日本インターベンショナルラジオロジー学会, 2016年06月, IVR: Interventional Radiology, 31 (2), 189 - 189, 日本語

  • TAEとデノスマブ投与の併用が奏功した仙骨巨細胞腫の1例

    谷 龍一郎, 岡田 卓也, 元津 倫幸, 片山 直人, 上嶋 英介, 小出 裕, 祖父江 慶太郎, 山口 雅人, 杉本 幸司, 河本 旭哉

    (一社)日本インターベンショナルラジオロジー学会, 2016年06月, IVR: Interventional Radiology, 31 (2), 182 - 182, 日本語

  • 【マルチモダリティによるAbdominal Imaging 2016[臨床編] 日常臨床における代表的疾患の画像診断のコツ】 先進技術・診断法の臨床応用の実際 Gd-EOB-DTPA造影MRIにおけるview sharingを用いた動脈相の多時相撮像の有用性

    祖父江慶太郎, 鶴崎正勝, 村上卓道, 上田優, 奥秋知幸, 杉村和朗

    2016年04月, INNERVISION, 31 (5号), 60 - 61, 日本語

    [招待有り]

    記事・総説・解説・論説等(商業誌、新聞、ウェブメディア)

  • 【マルチモダリティによるAbdominal Imaging 2016[臨床編] 日常臨床における代表的疾患の画像診断のコツ】 肝 肝細胞がんの診断

    鶴崎正勝, 村上卓道, 祖父江慶太郎

    2016年04月, INNERVISION, 31 (5号), 2 - 5, 日本語

    [招待有り]

    記事・総説・解説・論説等(商業誌、新聞、ウェブメディア)

  • 【これだけは知っておきたいCT/MRIの基本:研修医の必須知識】腫瘍性病変 肝・胆・膵

    祖父江 慶太郎, 岡田 卓也, 山口 雅人, 杉本 幸司, 杉村 和朗, 鶴崎 正勝, 村上 卓道

    (株)メジカルビュー社, 2016年04月, 臨床画像, 32 (4月増刊), 186 - 195, 日本語

    [招待有り]

    記事・総説・解説・論説等(商業誌、新聞、ウェブメディア)

  • ビーズ導入後のTACEの現状 多発肝細胞癌に対する非選択的DEB-TACEの有用性の検討

    岡田 卓也, 谷 龍一郎, 元津 倫幸, 片山 直人, 上嶋 英介, 小出 裕, 祖父江 慶太郎, 山口 雅人, 杉本 幸司

    (一社)日本インターベンショナルラジオロジー学会, 2016年04月, IVR: Interventional Radiology, 31 (Suppl.), 113 - 113, 日本語

  • ブタ肝後面下大静脈損傷モデルを用いたステントグラフトによる止血効果の検討

    井戸口 孝二, 山口 雅人, 片山 直人, 岡田 卓也, 上嶋 英介, 祖父江 慶太郎, 井芹 俊恵, 林 聡恵, 三重 慧一郎, 水島 靖明, 杉本 幸司

    (一社)日本インターベンショナルラジオロジー学会, 2016年04月, IVR: Interventional Radiology, 31 (Suppl.), 174 - 174, 日本語

  • 左総腸骨動脈閉塞を伴う腹部大動脈瘤に対するEVAR後にTypeII endoleak塞栓を繰り返した1例

    堀之内宏樹, 山口雅人, 丸山晃司, 臼井亮介, 元津倫幸, 谷龍一郎, 片山直人, 上嶋英介, 小出裕, 岡田卓也, 祖父江慶太郎, 後竹康子, 野村佳克, 大北裕, 杉本幸司

    2016年, 脈管学(Web), 56 (supplement), S188‐S189(J‐STAGE), 日本語

  • EVAR後の遅発性type1bエンドリークの危険因子に関する検討

    元津倫幸, 岡田卓也, 丸山晃司, 堀之内宏樹, 臼井亮介, 片山直人, 後竹康子, 谷龍一郎, 上嶋英介, 小出裕, 野村佳克, 祖父江慶太郎, 山口雅人, 大北裕, 杉本幸司

    2016年, 脈管学(Web), 56 (supplement), S137(J‐STAGE), 日本語

  • 上腸間膜動脈急性閉塞に対しフォガティースルールーメンカテーテルを用いて血栓除去を行った一例

    谷龍一郎, 山口雅人, 臼井亮介, 丸山晃司, 堀之内宏樹, 元津倫幸, 片山直人, 上嶋英介, 小出裕, 岡田卓也, 祖父江慶太郎, 杉本幸司, 野村佳克, 後竹康子, 大北裕

    2016年, 脈管学(Web), 56 (supplement), S207(J‐STAGE), 日本語

  • 当院における薬剤溶出性球状塞栓物質を用いたTACE(DEB-TACE)の初期治療成績

    片山 直人, 岡田 卓也, Muradi Akhmadu, 上嶋 英介, 小出 裕, 祖父江 慶太郎, 山口 雅人, 杉本 幸司

    (一社)日本インターベンショナルラジオロジー学会, 2015年09月, IVR: Interventional Radiology, 30 (3), 275 - 275, 日本語

  • 岡田 卓也, 山口 雅人, 片山 直人, Muradi Akhmadu, 上嶋 英介, 小出 裕, 祖父江 慶太郎, 杉本 幸司

    (一社)日本インターベンショナルラジオロジー学会, 2015年06月, IVR: Interventional Radiology, 30 (2), 166 - 171, 日本語

    [査読有り]

    記事・総説・解説・論説等(学術雑誌)

  • Keitaro Sofue, Yoshito Takeuchi, Yasuaki Arai, Kazuro Sugimura

    SPRINGER, 2014年10月, CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY, 37 (5), 1405 - 1406, 英語, 国際誌

    [査読有り]

  • Yoshito Takeuchi, Hiroyuki Morishita, Yozo Sato, Shingo Hamaguchi, Noriaki Sakamoto, Hiroyuki Tokue, Takafumi Yonemitsu, Kenji Murakami, Hiroyasu Fujiwara, Keitaro Sofue, Toshi Abe, Hideyuki Higashihara, Yasuo Nakajima, Morio Sato

    Cyanoacrylates are a group of fast-acting adhesives. They form low viscosity liquids in the monomer state and instantly polymerize to become adhesive upon contact with ionic substances. Since the 1950s, they have been used around the world for industrial and household purposes. N-butyl cyanoacrylate (NBCA) is a cyanoacrylate that is commonly used for medical care, and the closure of skin wounds with NBCA has been found to promote hemostasis. However, in Japan, the intravascular injection of NBCA is considered to be off-label use, except during the treatment of gastric varices under endoscopy. The use of NBCA in embolotherapy is considered when the target vessels cannot be cannulated superselectively, for vascular diseases that require long segments of the target vessel to be embolized, or for patients in a hypocoagulable state. NBCA-based embolotherapy can be used to treat vascular malformations, acute hemorrhaging, tumors, and venous disease. The complications associated with NBCA-based embolotherapy include tissue ischemia, hemorrhaging, systemic or local reactions, and catheter adhesion to blood vessels. NBCA is mixed with Lipiodol to make it radiopaque and to adjust its polymerization time. Since there are various technical aspects to performing NBCA-based embolotherapy safely, it should be carried out by, or with the assistance of, proficient interventional radiologists.

    SPRINGER, 2014年08月, JAPANESE JOURNAL OF RADIOLOGY, 32 (8), 500 - 517, 英語, 国内誌

    [査読有り]

  • 【腹部Interventional Radiologyの手技とコツ】腹部外傷に対するIVR

    杉本 幸司, 上嶋 英介, 片山 直人, 岡田 卓也, 小出 裕, 祖父江 慶太郎, 井戸口 孝二, 山口 雅人

    産業開発機構(株), 2014年08月, 映像情報Medical, 46 (8), 732 - 737, 日本語

    [招待有り]

    記事・総説・解説・論説等(商業誌、新聞、ウェブメディア)

  • 【NBCA塞栓術の現状と病理組織学的影響】NBCA塞栓術の現状と病理組織学的影響 膵臓

    岡田 卓也, 山口 雅人, Muradi Akhmadu, 片山 直人, 上嶋 英介, 小出 裕, 祖父江 慶太郎, 杉本 幸司

    (一社)日本インターベンショナルラジオロジー学会, 2014年08月, IVR: Interventional Radiology, 29 (3), 252 - 257, 日本語

    [招待有り]

    記事・総説・解説・論説等(学術雑誌)

  • 巨細胞動脈炎の関与が疑われる両側上腕動脈病変に対しPTAを施行した2例

    上嶋 英介, 山口 雅人, 井戸口 孝二, 祖父江 慶太郎, 岡田 卓也, 片山 直人, Muradi Akhmadu, 杉本 幸司

    (一社)日本インターベンショナルラジオロジー学会, 2014年06月, IVR: Interventional Radiology, 29 (2), 219 - 219, 日本語

  • 当院における非外傷性特発性後腹膜出血に対する動脈塞栓術の検討

    片山 直人, 祖父江 慶太郎, Muradi Akhmadu, 上嶋 英介, 岡田 卓也, 井戸口 孝二, 山口 雅人, 杉本 幸司

    (一社)日本インターベンショナルラジオロジー学会, 2014年06月, IVR: Interventional Radiology, 29 (2), 223 - 223, 日本語

  • 外傷IVRの基本と応用 脾損傷

    井戸口 孝二, 山口 雅人, 祖父江 慶太郎, 岡田 卓也, 上嶋 英介, 片山 直人, 小出 裕, Muradi Akhmadu, 杉本 幸司

    (一社)日本インターベンショナルラジオロジー学会, 2014年06月, IVR: Interventional Radiology, 29 (2), 188 - 194, 日本語

    [招待有り]

    記事・総説・解説・論説等(学術雑誌)

  • 【非外傷性出血のIVR】非外傷性の特発性後腹膜出血

    祖父江 慶太郎, 山口 雅人, 片山 直人, Muradi Akhmadu, 上嶋 英介, 小出 裕, 岡田 卓也, 井戸口 孝二, 杉本 幸司

    (一社)日本インターベンショナルラジオロジー学会, 2014年06月, IVR: Interventional Radiology, 29 (2), 140 - 146, 日本語

    [招待有り]

    記事・総説・解説・論説等(学術雑誌)

  • 周産期出血に対する子宮動脈塞栓術における子宮動脈造影所見の検討

    岡田 卓也, 山口 雅人, 上嶋 英介, Muradi Akhmadu, 片山 直人, 祖父江 慶太郎, 井戸口 孝二, 杉本 幸司

    (一社)日本インターベンショナルラジオロジー学会, 2014年05月, IVR: Interventional Radiology, 29 (Suppl.), 153 - 153, 日本語

  • 鈍的胸部大動脈損傷に対する企業性ステントグラフトを用いたTEVARの現状

    井戸口 孝二, 山口 雅人, 岡田 卓也, 上嶋 英介, 祖父江 慶太郎, 片山 直人, 小出 裕, Muradi Akhmadu, 杉本 幸司, 野村 佳克, 大北 裕, 森 岳樹

    (一社)日本インターベンショナルラジオロジー学会, 2014年05月, IVR: Interventional Radiology, 29 (Suppl.), 176 - 176, 日本語

  • 急性下肢動脈閉塞に対するFogarty Thru-Lumen catheterを用いた選択的血栓除去術の治療成績の検討

    片山 直人, 山口 雅人, 岡田 卓也, Muradi Akhmadu, 上嶋 英介, 野村 佳克, 祖父江 慶太郎, 井戸口 孝二, 大北 裕, 杉本 幸司

    (一社)日本インターベンショナルラジオロジー学会, 2014年05月, IVR: Interventional Radiology, 29 (Suppl.), 194 - 194, 日本語

  • EVAR後Type II Endoleak残存症例に対する追加治療の成績

    上嶋 英介, 山口 雅人, 井戸口 孝二, 祖父江 慶太郎, 岡田 卓也, 片山 直人, Muradi Akhmadu, 森 岳樹, 杉本 幸司

    (一社)日本インターベンショナルラジオロジー学会, 2014年05月, IVR: Interventional Radiology, 29 (Suppl.), 204 - 204, 日本語

  • 【救急疾患に対するIVR】泌尿器科領域の救急疾患に対するIVR

    岡田 卓也, 山口 雅人, Muradi Akhmadu, 片山 直人, 上嶋 英介, 祖父江 慶太郎, 井戸口 孝二, 杉本 幸司

    (一社)日本インターベンショナルラジオロジー学会, 2014年02月, IVR: Interventional Radiology, 29 (1), 34 - 42, 日本語

    [招待有り]

    記事・総説・解説・論説等(学術雑誌)

  • 【救急診療におけるCT・MRIとIVR】 IVR 上腸間膜動脈血栓塞栓症

    祖父江 慶太郎

    2013年09月, 救急医学, 37 (10号), 1382 - 1386, 日本語

    [招待有り]

    記事・総説・解説・論説等(商業誌、新聞、ウェブメディア)

  • 内臓動脈瘤に対するIVR 孤立性内腸骨動脈瘤に対する血管内治療の長期成績

    山口 雅人, Muradi Akhmadu, 井戸口 孝二, 祖父江 慶太郎, 岡田 卓也, 上嶋 英介, 野村 佳克, 川崎 竜太, 大北 裕, 杉本 幸司

    (一社)日本インターベンショナルラジオロジー学会, 2013年04月, IVR: Interventional Radiology, 28 (Suppl.), 103 - 103, 日本語

  • 出血に対するIVR 非外傷性特発性後腹膜出血に対する動脈塞栓術の検討

    祖父江 慶太郎, 山口 雅人, Muradi Akhmadu, 井戸口 孝二, 坂本 憲昭, 奥野 晃章, 岡田 卓也, 上嶋 英介, 杉本 幸司

    (一社)日本インターベンショナルラジオロジー学会, 2013年04月, IVR: Interventional Radiology, 28 (Suppl.), 105 - 105, 日本語

  • 当院における危機的産科出血に対する子宮動脈塞栓術の治療成績

    奥野 晃章, 山口 雅人, 岡田 卓也, 井戸口 孝二, 坂本 憲昭, 祖父江 慶太郎, 上嶋 英介, 杉本 幸司

    (一社)日本インターベンショナルラジオロジー学会, 2013年04月, IVR: Interventional Radiology, 28 (Suppl.), 173 - 173, 日本語

  • 【外科の基本 手術前後の患者さんを診る 手術の流れや手技、周術期管理が身につき、外科がわかる、好きになる】 (第2章)外科研修で覚えたい手技 CVポートの入れ方、管理のしかた

    祖父江 慶太郎, 荒井 保明

    2013年02月, レジデントノート, 14 (17号), 3259 - 3264, 日本語

    [招待有り]

    記事・総説・解説・論説等(商業誌、新聞、ウェブメディア)

  • 腹腔-静脈シャント造設術 (緩和ケア特集 イラストでわかる! 胸水・腹水の治療と看護をとことん理解する)

    祖父江 慶太郎, 竹内 義人, 荒井 保明

    メディカ出版, 2012年04月, プロフェッショナルがんナーシング, 2 (2), 141 - 144, 日本語

    [査読有り][招待有り]

    記事・総説・解説・論説等(商業誌、新聞、ウェブメディア)

  • 胸部領域における血管系インターベンションによる合併症 (特集 呼吸器検査法におけるハザード)

    祖父江 慶太郎, 荒井 保明, 竹内 義人

    克誠堂出版, 2012年02月, 日本胸部臨床, 71 (2), 155 - 162, 日本語

    [査読有り][招待有り]

    記事・総説・解説・論説等(商業誌、新聞、ウェブメディア)

  • Q&Aで綴る レジデント・ノート : 専門医がわかりやすく解説(No.30)中心静脈ポートについて,留置手技のコツ,合併症の予 防・対処法などの管理のコツを教えて下さい。

    祖父江 慶太郎, 荒井 保明

    メディカルレビュー社, 2011年12月, 大腸癌frontier, 4 (4), 401 - 404, 日本語

    [査読有り][招待有り]

    記事・総説・解説・論説等(商業誌、新聞、ウェブメディア)

  • 【エキスパートに学ぶIVRのテクニック、適応、合併症】膵臓:膵管ステント 十二指腸狭窄に対するステント

    祖父江 慶太郎, 荒井 保明, 竹内 義人, 高橋 正秀, 藤原 寛康, 徳江 浩之, 鶴崎 正勝, 坂本 憲昭, 荒井 保典

    (株)アークメディア, 2010年10月, 肝・胆・膵, 61 (4), 653 - 661, 日本語

    記事・総説・解説・論説等(商業誌、新聞、ウェブメディア)

  • 【ダイナミック局所解剖】大静脈とアクセスの解剖学的考察

    坂本 憲昭, 山口 雅人, 竹内 義人, 祖父江 慶太郎, 岡田 卓也, 伊崎 健太, 杉村 和朗, 杉本 幸司

    (一社)日本インターベンショナルラジオロジー学会, 2010年10月, IVR: Interventional Radiology, 25 (4), 427 - 434, 日本語

  • 【IVRのエビデンスを求めて】画像誘導下CV穿刺法のエビデンス

    竹内 義人, 荒井 保明, 坂本 憲昭, 高橋 正秀, 鶴崎 正勝, 藤原 寛泰, 祖父江 慶太郎, 徳江 浩之, 芝 奈津子

    金原出版(株), 2010年05月, 臨床放射線, 55 (5), 621 - 626, 日本語

    記事・総説・解説・論説等(学術雑誌)

  • 祖父江慶太郎, 荒井保明, 竹内義人, 高橋正秀

    2010年04月, IVR: Interventional Radiology, 25 (2号), 137 - 143, 日本語

    記事・総説・解説・論説等(学術雑誌)

  • IVRと超音波検査 エコーガイド下中心静脈穿刺法の技術

    竹内 義人, 坂本 憲昭, 祖父江 慶太郎, 徳江 浩之, 荒井 保明

    (一社)日本インターベンショナルラジオロジー学会, 2010年04月, IVR: Interventional Radiology, 25 (2), 211 - 216, 日本語

    [査読有り][招待有り]

    記事・総説・解説・論説等(学術雑誌)

  • 竹内 義人, 徳江 浩之, 祖父江 慶太郎, 坂本 憲昭

    (一社)日本インターベンショナルラジオロジー学会, 2010年01月, IVR: Interventional Radiology, 25 (1), 10 - 16, 日本語

    [査読有り][招待有り]

    記事・総説・解説・論説等(学術雑誌)

  • 慢性腎障害(CKD)症例における肝臓dynamic CTでの造影剤減量プロトコールの検討

    鶴崎 正勝, 祖父江 慶太郎, 三宅 基隆, 伊崎 健太, 山口 雅人, 川崎 竜太, 杉本 幸司, 藤井 正彦, 荒井 保明, 杉村 和朗

    (公社)日本医学放射線学会, 2009年02月, 日本医学放射線学会学術集会抄録集, 68回, S346 - S346, 日本語

  • 血管系IVRのエビデンス 1-4 画像誘導下CV穿刺法のエビデンス

    竹内義人, 荒井保明, 高橋正秀, 鶴崎正勝, 藤原寛康, 坂本憲昭, 祖父江慶太郎, 徳江浩之

    2009年, 日本医学放射線学会秋季臨床大会抄録集, 45th

  • 造影MRIの意義Revisited For the Beginners 腹部 膵臓

    祖父江慶太郎, 鶴崎正勝

    2008年07月, INNERVISION, 23 (8号), 73 - 79, 日本語

    [査読有り][招待有り]

    記事・総説・解説・論説等(商業誌、新聞、ウェブメディア)

  • がん患者の症状緩和 腹水

    竹内義人, 荒井保明, 高橋正秀, 鶴崎正勝, 坂本憲昭, 祖父江慶太郎, 荒井保典

    2008年04月, 緩和医療学, 10 (2号), 177 - 185, 日本語

    記事・総説・解説・論説等(学術雑誌)

  • 肝dynamic CTにおける注入時間一定法を用いたヨード造影剤減量プロトコールの検討

    鶴崎 正勝, 祖父江 慶太郎, 魚谷 健祐, 山口 雅人, 川崎 竜太, 杉本 幸司, 藤井 正彦, 荒井 保明, 杉村 和朗

    (公社)日本医学放射線学会, 2008年02月, 日本医学放射線学会学術集会抄録集, 67回, S145 - S146, 日本語

  • 【緩和医療で活用すべきInterventional Radiology(IVR)】 大静脈症候群に対するIVR

    竹内義人, 荒井保明, 高橋正秀, 鶴崎正勝, 坂本憲昭, 祖父江慶太郎, 荒井保典

    2007年10月, 緩和医療学, 9 (4号), 336 - 347, 日本語

    記事・総説・解説・論説等(学術雑誌)

  • 広田 佐栄子, 清水 雅史, 久保田 智之, 内田 伸恵, 平塚 純一, 高田 康弘, 宮脇 大輔, 辻野 佳世子, 金岡 徳芳, 泉山 一隆, 祖父江 慶太郎

    【目的】乳癌の胸壁または残存乳腺に対する放射線治療後の肺有害事象とアレルギー素因との関連性を探る. 【対象と方法】当院および協力医療機関 8 施設において, 1980年12月から2005年10月までの間の任意の期間において連続して乳癌の胸壁または残存乳腺に対する放射線治療を施行した1,173症例1,177乳房を解析対象とした. アレルギー素因としては, 喘息, アレルギー性鼻炎, アトピー性皮膚炎, 接触性皮膚炎, 食物または薬剤過敏の履歴があることを定義とした(全症例のうち111例が有素因例). この111例のうち, 6 カ月以上経過観察できたか, それまでに肺有害事象を惹起した症例は85例であり, これをA群(アレルギー素因例)とした. また, 当院の症例でアレルギー素因の有無にかかわらず, 6 カ月以上経過が観察できたか, それまでに肺有害事象を惹起した症例は113例であったが, これをB群(アレルギー素因を問わない群)とし, B群のうち, アレルギー素因のないもの92例をC群(非アレルギー素因群)とした. 【結果】NCI-CTCAE(v.3.0)のGrade 3 以上の肺有害事象を呈したのはA群8.2%(7 例), B群2.7%(3 例), C群1.1%(1 例)であり, A群とC群の間に有意差を認めた(p = 0.0293). A群の 7 例のうちclassical pneumonitis(炎症が照射野内にほぼ一致するもの)が 3 例で, sporadic pneumonitis(炎症が照射野外にも広がるもの)は 4 例であった. 当院において, 組織学的に確認されたsporadic pneumonitisであるところの特発性器質化肺炎(COP)の 1 例と慢性好酸球性肺炎(CEP)の 1 例を経験したが, どちらもアレルギー素因を有していた. これらの詳細な臨床経過は本文内に記載した. 【結語】アレルギー素因を有することは, 乳癌の胸壁または残存乳腺に対する放射線治療後の肺有害事象の危険因子のひとつである可能性が示唆された.

    一般社団法人 日本放射線腫瘍学会, 2007年06月25日, The Journal of JASTRO = 日本放射線腫瘍学会誌, 19 (2), 109 - 116, 日本語

    [査読有り]

    記事・総説・解説・論説等(学術雑誌)

  • 当院にて経験したPopliteal Artery Entrapment Syndrome

    河野 淳, 石井 一成, 祖父江 慶太郎, 宮本 直和, 福田 哲也

    バイエル薬品(株), 2007年05月, 日独医報, 52 (1), 129 - 129, 日本語

  • 縊頸を機に発症したreversible posterior leukoencephalopathy syndromeの一例

    祖父江 慶太郎, 山口 雅人, 森 岳樹, 杉本 幸司, 山本 真士, 米田 行宏, 中山 伸一

    (公社)日本医学放射線学会, 2007年04月, Radiation Medicine, 25 (Suppl.I), 64 - 64, 日本語

  • 急性腎不全を来したI型大動脈解離による腎動脈狭窄に対してstentを留置した1例

    宮本 直和, 福田 哲也, 祖父江 慶太郎, 河野 淳, 吉川 俊紀, 石井 一成, 圓尾 文子, 向原 伸彦, 吉田 正人, 志田 力

    (一社)日本インターベンショナルラジオロジー学会, 2007年04月, IVR: Interventional Radiology, 22 (2), 267 - 267, 日本語

  • 河野 淳, 石井 一成, 祖父江 慶太郎, 宮本 直和, 金田 純子, 喜多 也寸志, 杉村 和朗

    (一社)日本核医学会, 2006年11月, 核医学, 43 (4), 367 - 367, 日本語

  • 軽症レビー小体型認知症とアルツハイマー病のFDG-PET全自動コンピューター補助診断

    河野 淳, 石井 一成, 祖父江 慶太郎, 宮本 直和, 坂本 攝, 杉村 和朗

    (一社)日本核医学会, 2006年10月, 核医学, 43 (3), 242 - 243, 日本語

  • Comparison of morphologic and metabolic reduction in mild dementia with Lewy bodies and Alzheimer disease

    K. Ishii, T. Soma, A. K. Kono, K. Sofue, N. Miyamoto, A. Sakurai, K. Murase

    SPRINGER, 2006年09月, EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 33, S295 - S295, 英語

    研究発表ペーパー・要旨(国際会議)

  • 特発性脊椎硬膜外血腫の2例

    河野 淳, 藤井 正彦, 杉村 和朗, 祖父江 慶太郎, 宮本 直和, 石井 一成, 木村 英仁, 本岡 康彦, 川口 哲郎

    (公社)日本医学放射線学会, 2006年09月, 日本医学放射線学会秋季臨床大会抄録集, 42回, S518 - S518, 日本語

  • TASCB・C型腸骨動脈病変に対する血管内治療とbypass術の比較

    宮本 直和, 福田 哲也, 祖父江 慶太郎, 河野 淳, 吉川 俊紀, 石井 一成, 杉村 和朗, 吉田 正人, 向原 伸彦, 志田 力

    (一社)日本脈管学会, 2006年09月, 脈管学, 46 (Suppl.), S204 - S204, 日本語

  • 【肺血栓塞栓症に必要な画像診断およびIVR】肺血栓塞栓症と深部静脈血栓症のIVR治療

    杉本 幸司, 山口 雅人, 森 岳樹, 祖父江 慶太郎, 新家 俊郎, 川合 宏哉, Zamora Carlos A., 大野 良治, 杉村 和朗

    (株)メジカルビュー社, 2006年07月, 臨床画像, 22 (7), 791 - 799, 日本語

    [査読有り][招待有り]

    記事・総説・解説・論説等(学術雑誌)

  • 透析シャント不全に対するカッティングバルーンの初期使用経験

    祖父江 慶太郎, 山口 雅人, 森 岳樹, 杉本 幸司

    (一社)日本インターベンショナルラジオロジー学会, 2006年04月, IVR: Interventional Radiology, 21 (2), 213 - 214, 日本語

  • Wallstent留置にて治療した鈍的骨盤外傷による腸骨静脈損傷の1例

    祖父江 慶太郎, 山口 雅人, 森 岳樹, 杉本 幸司, 黒川 剛史, 中村 雅彦, 中山 伸一, 小澤 修一

    (一社)日本インターベンショナルラジオロジー学会, 2006年04月, IVR: Interventional Radiology, 21 (2), 219 - 219, 日本語

  • 鈍的骨盤外傷に伴う腸骨静脈損傷症例の画像診断

    森 岳樹, 山口 雅人, 祖父江 慶太郎, 杉本 幸司, 中山 伸一, 小澤 修一

    (公社)日本医学放射線学会, 2006年02月, 日本医学放射線学会学術集会抄録集, 65回, S255 - S255, 日本語

  • 透析シャント不全に対するカッティングバルーンの初期成績

    祖父江 慶太郎, 森 岳樹, 山口 雅人, 杉本 幸司

    (公社)日本医学放射線学会, 2006年02月, 日本医学放射線学会学術集会抄録集, 65回, S331 - S331, 日本語

  • 大腸憩室出血におけるair enema併用造影dynamic CTの有用性

    岩本 和也, 堀松 高博, 坂下 正典, 藤井 正俊, 岡林 克典, 祖父江 慶太郎, 山口 雅人, 森 岳樹, 杉本 幸治

    (一財)日本消化器病学会, 2005年09月, 日本消化器病学会雑誌, 102 (臨増大会), A779 - A779, 日本語

  • 開院後1年6ヵ月の期間に経験した食道表在癌の検討

    堀松 高博, 坂下 正典, 藤井 正俊, 小幡 大輔, 岩本 和也, 岡林 克典, 田村 竜二, 岡本 貴大, 門脇 嘉彦, 森 隆, 坂田 龍彦, 江島 泰正, 祖父江 慶太郎, 山口 雅人, 森 岳樹, 杉本 幸司, 高橋 卓也

    (一財)日本消化器病学会, 2005年09月, 日本消化器病学会雑誌, 102 (臨増大会), A704 - A704, 日本語

  • 透析シャント不全に対するカッティングバルーンの初期使用経験

    祖父江 慶太郎, 山口 雅人, 森 岳樹, 杉本 幸司

    (一社)日本インターベンショナルラジオロジー学会, 2005年07月, IVR: Interventional Radiology, 20 (3), 330 - 330, 日本語

  • 経カテーテル的動脈塞栓術が奏功した腰動脈鋭的損傷の2例

    祖父江 慶太郎, 山口 雅人, 森 岳樹, 杉本 幸司, 門脇 嘉彦, 中山 伸一

    (一社)日本インターベンショナルラジオロジー学会, 2005年02月, IVR: Interventional Radiology, 20 (2), 212 - 212, 日本語

  • 大動脈解離に対する血管ステントの応用

    山口 雅人, 杉本 幸司, 森 岳樹, 祖父江 慶太郎, 築部 卓郎, 林 太郎, 谷口 尚範, 川崎 竜太, 鶴崎 正勝, カルロス・サモラ, 杉村 和朗, 辻 義彦, 大北 裕

    (一社)日本インターベンショナルラジオロジー学会, 2005年02月, IVR: Interventional Radiology, 20 (2), 215 - 216, 日本語

  • ステントグラフト留置が有用であった分枝虚血障害合併B型大動脈解離の1例

    山口 雅人, 祖父江 慶太郎, 森 岳樹, 杉本 幸司, 林 太郎, 築部 卓郎

    (一社)日本インターベンショナルラジオロジー学会, 2005年02月, IVR: Interventional Radiology, 20 (2), 216 - 216, 日本語

  • 分枝虚血合併B型大動脈解離に対する血管内治療 特にステント留置,経皮的開窓術を用いて治療した自験例を中心に

    山口 雅人, 杉本 幸司, 森 岳樹, 祖父江 慶太郎, 谷口 尚範, 川崎 竜太, 鶴崎 正勝, サモラ・カルロス, 杉村 和朗, 辻 義彦, 大北 裕

    金原出版(株), 2005年01月, 臨床放射線, 50 (1), 59 - 66, 日本語

    記事・総説・解説・論説等(学術雑誌)

  • air enema併用造影dynamic CTによる大腸憩室出血の描出能 IVR術前評価における有用性について

    祖父江 慶太郎, 森 岳樹, 山口 雅人, 杉本 幸司, 藤井 正俊, 坂下 正典, 岩本 和也, 杉村 和朗

    (公社)日本医学放射線学会, 2004年09月, 日本医学放射線学会雑誌, 64 (6), S414 - S414, 日本語

  • 脊髄に発生したdiffuse midline glioma,H3K27M-mutantの3例

    小路田泰之, 神田知紀, 上野嘉子, 西尾瑞穂, 河野淳, 祖父江慶太朗, 野上宗伸, 前田隆樹, 堀雅敏, 村上卓道

    2021年, 日本神経放射線学会プログラム・抄録集, 50th

  • 胎児MRIの頭部画像を用いたディープラーニングによる胎児の週数予測

    小路田泰之, 松尾秀俊, 神田知紀, 西尾瑞穂, 河野淳, 祖父江慶太郎, 野上宗伸, 村上卓道

    2020年, 日本神経放射線学会プログラム・抄録集, 49th

  • 悪性腫瘍の全身FDG PET/MRIにおけるBSREMを用いた高速撮像と診断能の検討

    犬養純子, 野上宗伸, 曽菲比, 渡邊慶明, 西尾瑞穂, 神田知紀, 祖父江慶太郎, 河野敦, 久保和広, 村上卓道

    2020年, 核医学(Web), 57 (Supplement)

書籍等出版物

  • 肝臓専門医テキスト改訂第3版

    祖父江慶太郎, 村上卓道

    共著, II章 A.検査 7画像診断, 南江堂, 2020年11月, 120-150, 日本語

    教科書・概説・概論

  • 肝癌診療マニュアル第4版

    祖父江慶太郎, 吉満研吾, 村上卓道

    共著, 第5章 肝癌の診断 B画像診断 1.総論, 医学書院, 2020年04月, 53-56, 日本語

    学術書

  • 今日の診断指針 第8版

    西岡瑛子, 祖父江慶太郎

    分担執筆, Ⅱ疾患編 3消化器疾患 肝良性腫瘍, 医学書院, 2020年03月, 783-786, 日本語, 良性肝腫瘍の診断に重要な点を解説

    学術書

  • 肝癌診療ガイドライン 2017年版補訂版

    日本肝臓学会

    分担執筆, 第6章 肝動脈(化学)塞栓療法TA(C)E, 金原出版, 2020年02月20日, 159-184, 日本語, ISBN: 4307204093

    学術書

  • Multislice CT Fourth Edition.

    Keitaro Sofue, Masakatsu Tsurusaki, Takamichi Murakami

    分担執筆, [Part IV Abdomen: Cirrhotic Liver.], Springer, 2019年, 447-489, 英語

    教科書・概説・概論

  • 特集:肝癌-診断・治療の最新知見- / II. 肝癌の診断 ダイナミックCT・MRI

    祖父江慶太郎, 鶴崎正勝, 村上卓道

    その他, 日本臨床, 2018年, 日本語

    学術書

  • プリンシプル消化器疾患の臨床 3.ここまできた肝臓病診療 / II章:検査・診断 画像検査 –血管造影-

    鶴崎正勝, 祖父江慶太郎, 村上卓道

    その他, 中山書店, 2017年, 日本語

    学術書

  • プリンシプル消化器疾患の臨床 3.ここまできた肝臓病診療 / II章:検査・診断 画像検査 -CT-

    祖父江慶太郎, 鶴崎正勝, 村上卓道

    その他, 中山書店, 2017年, 日本語

    学術書

  • 画像診断ガイドライン2016年度版 / 【CQ90 急性胆嚢炎が疑われた場合、行うべき画像検査は何か?】

    祖父江慶太郎

    その他, 金原出版, 2016年04月, 日本語

    学術書

  • Key所見から読む肝胆膵の画像診断 MRI T1強調像 高信号結節

    祖父江 慶太郎

    メジカルビュー社, 2016年03月

  • Key所見から読む肝胆膵の画像診断 MRI T1強調像 肝実質の低信号

    祖父江 慶太郎

    メジカルビュー社, 2016年03月

  • Key所見から読む肝胆膵の画像診断 MRI T1強調像 肝実質の高信号

    祖父江 慶太郎

    メジカルビュー社, 2016年03月

  • 動画で身につく肝疾患の基本手技 -インターベンション治療の秘訣- / 第3章2-2 全身化学療法のためのCVポート留置術

    祖父江慶太郎, 荒井保明

    その他, 羊土社, 2013年, 日本語

    学術書

  • 画像診断ガイドライン2013年度版 / CQ79 急性胆嚢炎が疑われた場合行われる画像検査は何か?

    祖父江慶太郎

    その他, 金原出版, 2013年, 日本語

    学術書

  • 血管塞栓術に用いるNBCAのガイドライン

    竹内 義人, 坂本 憲昭, 佐藤 洋造, 祖父江 慶太郎, 徳江 浩之, 濱口 真吾, 藤原 寛康, 村上 健司, 森下 博之, 米満 尚史

    共著, CQ9 他の塞栓物質との併用は有用か?, 一般社団法人 日本IVR学会編, 2012年

講演・口頭発表等

  • 腹部領域での画像診断~おさえておくべきポイント~ 臨床に役立つ肝細胞癌の画像診断

    祖父江慶太郎

    第56回日本医学放射線学会秋季臨床大会20, 2020年10月28日, 日本語

    [招待有り]

    公開講演,セミナー,チュートリアル,講習,講義等

  • 肝の最新MRI びまん性肝疾患における定量MRIの臨床応用

    祖父江慶太郎

    第48回日本磁気共鳴医学会大会, 2020年09月13日, 日本語, 日本磁気共鳴医学会, web開催, 国内会議

    [招待有り]

    シンポジウム・ワークショップパネル(指名)

  • 肝胆膵の画像診断 肝切除後肝不全の予測における画像診断の有用性

    祖父江慶太郎

    第79回日本医学放射線学会総会, 2020年05月20日, 日本語, 日本医学放射線学会, Web開催, 国内会議

    [招待有り]

    公開講演,セミナー,チュートリアル,講習,講義等

  • 腹部造影CTの最前線 肝細胞癌に対する薬物療法と画像診断

    祖父江慶太郎

    第79回日本医学放射線学会総会, 2020年05月20日, 日本語, 日本医学放射線学会, Web開催, 国内会議

    [招待有り]

    公開講演,セミナー,チュートリアル,講習,講義等

  • 肝臓学源平合戦 ~Pros and Cons~

    祖父江慶太郎

    第43回日本肝臓学会西部会, 2019年12月12日, 日本語, 日本肝臓学会, 下関, 日本国, 国内会議

    シンポジウム・ワークショップパネル(指名)

  • Development and Assessment of Respiratory Motion-Resolved Hepatobiliary Phase Cine-MRI using Compressed SENSE for Stereotactic Body Radiotherapy in Liver Tumor.

    Shimada R, Sofue K, Kyotani K, Wang T, Ueno Y, Ishihara T, Horii S, Nogami M, Kusaka A, Murakami T

    105th Radiological Society of North America, Scientific Assembly and Annual Meeting., 2019年12月, 英語, Radiological Society of North America, Chicago, アメリカ合衆国, 国際会議

    口頭発表(一般)

  • Utility of Extracellular Volume Fraction Measured from Multiphasic Contrast-Enhanced Computed Tomography for the Estimation of Pancreatic Fibrosis.

    Sofue K, Ueno Y, Ueshima E, Tani R, Horinouchi H, Maruyama K, Okada T, Yamaguchi M, Sugimoto K, Murakami T

    105th Radiological Society of North America, Scientific Assembly and Annual Meeting., 2019年12月, 英語, Radiological Society of North America, Chicago, アメリカ合衆国, 国際会議

    ポスター発表

  • 肝腫瘤性病変の画像診断:肝炎症性腫瘤の画像診断

    祖父江慶太郎

    第55回 日本医学放射線学会 秋季臨床大会, 2019年10月18日, 日本語, 日本医学放射線学会, 名古屋, 日本国, 国内会議

    公開講演,セミナー,チュートリアル,講習,講義等

  • 肝画像診断における最新MRI技術の臨床的意義:転移性肝癌の診断

    祖父江慶太郎

    第47回 日本磁気共鳴医学会大会, 2019年09月20日, 日本語, 日本磁気共鳴医学会, 熊本, 日本国, 国内会議

    公開講演,セミナー,チュートリアル,講習,講義等

  • Dual-Energy CT Applications in the Liver

    祖父江慶太郎

    The 10th Asia-Pacific Primary Liver Cancer Expert Meeting, 2019年08月31日, 英語, APPLE, 札幌, 日本国, 国際会議

    [招待有り]

    公開講演,セミナー,チュートリアル,講習,講義等

  • Dual-Energy CTを用いた上腹部画像診断

    祖父江慶太郎

    第3回西新宿Radiology Forum, 2019年08月27日, 日本語, 東京, 日本国, 国内会議

    公開講演,セミナー,チュートリアル,講習,講義等

  • 各領域の進歩3:肝臓

    祖父江慶太郎

    Advanced Medical Imaging研究会2019, 2019年07月28日, 日本語, Advanced Medical Imaging研究会, 大阪, 日本国, 国内会議

    シンポジウム・ワークショップパネル(指名)

  • 肝細胞癌に対する分子標的療法における画像的効果判定

    祖父江慶太郎

    Advanced Medical Imaging研究会2019, 2019年07月27日, 日本語, Advanced Medical Imaging研究会, 大阪, 日本国, 国内会議

    公開講演,セミナー,チュートリアル,講習,講義等

  • 肝転移における肝特異性造影MRIの意義

    祖父江慶太郎

    JRCミッドサマーセミナー2019, 2019年07月20日, 日本語, 日本放射線医会, 神戸, 日本国, 国内会議

    公開講演,セミナー,チュートリアル,講習,講義等

  • LI-RADS CT・MRI

    祖父江慶太郎

    第29回 関西肝血流動態・機能イメージ研究会, 2019年07月06日, 日本語, 肝血流動態・機能イメージ研究会, 大阪, 日本国, 国内会議

    公開講演,セミナー,チュートリアル,講習,講義等

  • 腹部領域の画像診断 おさえておくべきポイント 造影CTを用いた上腹部臓器の線維化定量

    祖父江慶太郎

    第33回 日本腹部放射線学会, 2019年06月28日, 日本語, 日本腹部放射線学会, 下関, 日本国, 国内会議

    公開講演,セミナー,チュートリアル,講習,講義等

  • 肝細胞癌に対する分子標的療法における画像的効果判定

    祖父江慶太郎

    第2回天王寺若手肝疾患カンファレンス, 2019年06月06日, 日本語, 大阪, 日本国, 国内会議

    公開講演,セミナー,チュートリアル,講習,講義等

  • Diverse Perspectives on Imaging-Based Diagnosis of HCC -Asian Guidelines-

    祖父江慶太郎

    ISMRM 27th Annual Meeting and Exhibition, 2019年05月13日, 英語, ISMRM, モントリオール, カナダ, 国際会議

    公開講演,セミナー,チュートリアル,講習,講義等

  • Utility of Extracellular Volume Fraction Measured from Multiphasic Contrast-Enhanced Computed Tomography for the Estimation of Pancreatic Fibrosis.

    Keitaro Sofue, Yoshiko Ueno, Eisuke Ueshima, Ryuichiro Tani, Hiroki Horinouchi, Koji Maruyama, Takuya Okada, Masato Yamaguchi, Koji Sugimoto, Takamichi Murakami

    104th Radiological Society of North America, Scientific Assembly and Annual Meeting., 2018年11月, 英語, 国際会議

    ポスター発表

  • Impact of respiratory-gated MR attenuation correction and PET reconstruction algorithm on FDG PET/MR

    Munenobu Nogami, Feibi Zeng, Yuichi Wakabayashi, Yoshiko R. Ueno, Tomonori Kanda, Keitaro Sofue, Takako Kurimoto, Kazuhiro Kubo, Takamichi Murakami

    The 58th Annual Scientific Meeting of the Japanese Society of Nuclear Medicine, 2018年11月, 英語, Japanese Society of Nuclear Medicine (JSNM), Okinawa, 国内会議

    口頭発表(一般)

  • 当院における経腟分娩後の産道出血に対する動脈塞栓術の検討

    佐々木 康二, 岡田 卓也, ハマダ モスタファ, 元津 倫幸, 谷 龍一郎, 上嶋 英介, 小出 裕, 祖父江 慶太郎, 山口 雅人, 杉本 幸司, 村上 卓道

    兵庫県IVR懇話会, 2018年11月, 日本語, 富士製薬工業株式会社, 神戸, 国内会議

    口頭発表(一般)

  • New and Updated Topics in Targeted Therapies for the Treatment of Advanced and Metastatic Renal Cell Carcinoma: What Radiologists Should Know

    Yoshiko Ueno, Tsutomu Tamada, Satoru Takahashi, Keitaro Sofue, Utaru Tanaka, Takamichi Murakami

    The 104th Scientific Assembly and Annual Meeting of the Radiological Society of North America, 2018年11月, 英語, Chicago, 国際会議

    ポスター発表

  • 翼口蓋窩に生じた筋上皮腫の1例

    立花美保, 神田知紀, 田中宇多留, 上野嘉子, 祖父江慶太郎, 前田隆樹, 野上宗伸, 村上卓道, 神澤真紀, 伊藤智雄

    第54回日本医学放射線学会秋季臨床大会(第31回頭頸部放射線研究会), 2018年10月, 日本語, 福岡, 国内会議

    口頭発表(一般)

  • Secondary Liver Cancer - Radiologist's perspective - detecting small liver metastasis (primary colorectal carcinoma)

    Keitaro Sofue

    3rd Asia Pacific Liver Imaging Symposium (APLIS 2018), 2018年10月, 英語, Bayer, Shanghai, 国際会議

    シンポジウム・ワークショップパネル(指名)

  • Retinal Vasculopathy with Cerebral leukoencephalopathy (RVCL) の一例

    田中千賀, 神田知紀, 上野嘉子, 岡田卓也, 祖父江慶太郎, 前田隆樹, 野上宗伸, 山口雅人, 杉本幸司, 村上卓道

    第51回兵庫県磁気共鳴医学研究会, 2018年07月, 日本語, 神戸, 国内会議

    口頭発表(一般)

  • 破裂性十二指腸静脈瘤に対してバルーン閉塞下逆行性静脈瘤塞栓術を施行した一例

    小出裕, 岡田卓也, 佐々木康二, 元津倫幸, ハマダ モスタファ, 谷龍一郎, 上嶋英介, 祖父江慶太郎, 山口雅人, 杉本幸司, 村上卓道

    第65回関西IVR研究会, 2018年06月, 日本語, 大阪, 国内会議

    口頭発表(一般)

  • (教育講演) 肝細胞癌に対する画像診断ガイドラインと分子標的療法の現状

    祖父江 慶太郎

    第6回金沢兼六画像診断研究会, 2018年06月, 日本語, 国内会議

    口頭発表(一般)

  • 術前診断が困難であった副腎血管肉腫の1例

    宮崎亜樹, 上野嘉子, 田中宇多留, 祖父江慶太郎, 髙橋哲, 日向信之, 藤澤正人, 原重雄, 藤倉航平, 伊藤智雄, 村上卓道

    第32回日本腹部放射線学会, 2018年05月, 日本語, 鎌倉, 国内会議

    口頭発表(一般)

  • Embolization for acute hemorrhage in patients with head and neck cancer

    Koide Y, Okada T, Mostafa H, Sasaki K, Maruyama K, Horinouchi H, Gentsu T, Tani R, Eushima E, Sofue K, Yamaguchi M, Sugimoto K, Murakami T

    The Joint Meeting of the 47th Meeting of the Japanese Society of Interventional Radiology & The 13th Meeting of the International Symposium of Interventional Radiology, 2018年05月, 英語, Tokyo, 国際会議

    口頭発表(一般)

  • The feasibility of preoperative embolization for partial resection of hypervascular spinal tumor

    Tani R, Ueshima E, Hamada M, Sasaki K, Maruyama K, Horinouchi H, Gentsu T, Koide Y, Okada T, Sofue K, Yamaguchi M, Sugimoto K, Murakami T

    The Joint Meeting of the 47th Meeting of the Japanese Society of Interventional Radiology & The 13th Meeting of the International Symposium of Interventional Radiology, 2018年05月, 英語, 国際会議

    口頭発表(一般)

  • Embolization with NBCA for acute bleeding from pancreatic and peripancreatic arteries

    Sasaki K, Okada T, Mostafa H, Maruyama K, Horinouchi H, Gentsu T, Tani R, Ueshima E, Koide Y, Sofue K, Yamaguchi M, Sugimoto K, Murakami T

    The Joint Meeting of the 47th Meeting of the Japanese Society of Interventional Radiology & The 13th Meeting of the International Symposium of Interventional Radiology, 2018年05月, 英語, 国際会議

    口頭発表(一般)

  • Histological and molecular characterization of intrahepatic bile duct cancers suggests an expanded definition of perihilar cholangiocarcinoma

    Akita M, Sofue K, Ueno K, Tsugawa D, Hashimoto Y, Ajiki T, Fukumoto T, Zen Y

    The 5th Yeungnam-Kasai HBP Surgeons Joint Meeting 2018, 2018年03月, 英語, 和歌山県立医科大学, Daegu, Korea, 国際会議

    [招待有り]

    ポスター発表

  • 線維軟骨塞栓症が疑われた若年者脊髄梗塞の一例

    藤原康弘, 神田知紀, 上野嘉子, 岡田卓也, 祖父江慶太郎, 前田隆樹, 野上宗伸, 山口雅人, 杉本幸司, 村上卓道, 大塚喜久

    第319回日本医学放射線学会関西地方会, 2018年02月, 日本語, 大阪, 国内会議

    口頭発表(一般)

  • 子宮広間膜に発生した平滑筋肉種の一例

    宮﨑亜樹, 上野嘉子, 田中宇多留, 祖父江慶太郎, 村上卓道, 原重雄, 藤倉航平, 伊藤智雄, 蝦名康彦, 山田秀人, 前田哲雄

    第318回日本医学放射線学会関西地方会, 2018年02月, 英語, 大阪, 国内会議

    口頭発表(一般)

  • 子宮広間膜に発生した平滑筋肉腫の一例

    宮﨑 亜樹, 上野 嘉子, 田中宇多留, 祖父江慶太郎, 原 重雄, 藤倉 航平, 伊藤 智雄, 蝦名 康彦, 山田 秀人, 前田 哲雄, 村上 卓道

    第390回日本医学放射線学会関西地方会, 2018年02月, 日本語, 日本医学放射線学会, 大阪, 国内会議

    [招待有り]

    口頭発表(一般)

  • Quantification of Cisplatin Concentration by using Material Decomposition Algorithm at 3rd Generation Dual Source Dual-Energy CT -An Experimental Phantom Study-.

    Sofue K, Itoh T, Shimada R, Nishitani T, Negi H, Sugimura K, Takahashi S

    104th Radiological Society of North America, Scientific Assembly and Annual Meeting., 2017年12月, 英語, Radiological Society of North America, Chicago, USA, 国際会議

    [招待有り]

    口頭発表(一般)

  • Dual-Energy CT for Noninvasive Staging of Liver Fibrosis: Accuracy of Iodine Density Measurements from Contrast-Enhanced Data.

    Sofue K, Tsurusaki M, Hyodo T, Sasaki K, Mileto A, Sugimura K, Murakami T

    103th Radiological Society of North America, Scientific Assembly and Annual Meeting., 2017年12月, 英語, Radiological Society of North America, Chicago, USA, 国際会議

    [招待有り]

    ポスター発表

  • Comparison of Integrated 18F-FDG PET/MRI Without Contrast Agents and Dynamic Contrast-enhanced MRI in Evaluating FIGO Stage in Uterine Cancer: A Preliminary Study

    上野 嘉子, 野上 宗伸, 田中 宇多留, 祖父江 慶太郎, 北島 一宏, 久保 和宏, 杉村 和朗, 髙橋 哲

    第103回北米放射線学会, 2017年12月, 英語, Radiological Society of North America, Chicago, USA, 国際会議

    [招待有り]

    ポスター発表

  • Clinical Significance of FDG PET in Combination with International Consensus Guidelines 2012 for the Management of Intraductal Papillary Mucinous Neoplasms of the Pancreas.

    Sofue K, Tani R, Nogami M, Ueno Y, Horinouchi H, Okada T, Yamaguchi M, Sugimoto K, Sugimura K, Takanashi S

    105th Radiological Society of North America, Scientific Assembly and Annual Meeting., 2017年12月, 英語, Radiological Society of North America, Chicago, USA, 国際会議

    [招待有り]

    ポスター発表

  • F-18 FDG PET/MRを用いた消化管の生理的集積に関する検討:FDG集積とMRI信号との対比

    野上 宗伸, 下山 真介, 若林 雄一, 田中 宇多留, 上野 嘉子, 祖父江 慶太郎, 久保 和広, 高橋 哲

    第57回日本核医学会総会, 2017年10月, 英語, 日本核医学会, 横浜, 【目的】PET/MR一体型装置を用いて消化管の生理的なFDG集積を評価し,MRI信号との関連を検討する【方法】消化管疾患を伴わない80例を対象に後方視的に検討した.PET収集とともに,全身MRIの横断像撮像を行った.消化管は手動で抽出され,次に2 point DIXON法の脂肪画像上で閾値を用い消化管周囲の脂肪織を除外した.得られた関心領域は複写され,閾値を用いて,T1 /T2強調画像での信号の組み合わせから4領域に分割した.各関心領域は同時収集されたPET画像上に複写され,平均SUVを測定した. 【結果】T1/T2強調画像で高/低信号を呈する領域で,下行結腸の集積(1.0±0.3)が上部消化管と比して有意に低値であった(p<0.0001). T1/T2強調画像で低/高信号を呈する領域では,回腸の集積(2.2±0.6)が他と比して有意に高値であった(, 国内会議

    [招待有り]

    口頭発表(一般)

  • Balloon-occluded retrograde transvenous obliteration for duodenal varices.

    Okada T, Maruyama K, Horinouchi H, Gentsu T, Tani R, Usui R, Katayama N, Ueshima E, Koide Y, Sofue K, Yamaguchi M, Sugimoto K

    CIRSE (Cardiovascular and Interventional Radiological Society of Europe) Annual Scientific Meeting, 2017年09月, 英語, CIRSE, Copenhagen, Denmark, 国際会議

    [招待有り]

    ポスター発表

  • Dual-Energy CTから得られたヨード密度画像を用いた肝線維化の評価

    祖父江慶太郎, 鶴崎正勝, 兵頭朋子, 佐々木公祐, 矢田典久, 工藤正俊, 杉村和朗, 村上卓道

    第2回Advanced Medical Imaging研究会, 2017年07月, 日本語, Society of Advanced Medical Imaging, 大阪, 国内会議

    [招待有り]

    ポスター発表

  • 動脈塞栓術を施行した腎部分切除術後の仮性動脈瘤の検討

    臼井 亮介, 岡田 卓也, 丸山 晃司, 堀之内 宏樹, 元津 倫幸, 谷 龍一郎, 片山 直人, 上嶋 英介, 小出 裕, 祖父江 慶太郎, 山口 雅人, 杉本 幸司

    第46回日本IVR学会総会, 2017年05月, 日本語, 日本IVR学会, 岡山, 国内会議

    [招待有り]

    口頭発表(一般)

  • 十二指腸静脈瘤に対するB-RTOの有効性の検討

    丸山 晃司, 岡田 卓也, 堀之内 宏樹, 元津 倫幸, 谷 龍一郎, 片山 直人, 上嶋 英介, 小出 裕, 祖父江 慶太郎, 山口 雅人, 杉本 幸司

    第46回日本IVR学会総会, 2017年05月, 日本語, 日本IVR学会, 岡山, 国内会議

    [招待有り]

    口頭発表(一般)

  • 腫瘍性脊椎圧骨折に対する経皮的椎体形成術の検討

    谷 龍一郎, 岡田 卓也, 丸山 晃司, 堀之内 宏樹, 臼井 亮介, 元津 倫幸, 片山 直人, 上嶋 英介, 小出 裕, 祖父江 慶太郎, 山口 雅人, 杉本 幸司

    第46回日本IVR学会総会, 2017年05月, 日本語, 日本IVR学会, 岡山, 国内会議

    [招待有り]

    口頭発表(一般)

  • IVR技術のいろは 超音波ガイド下穿刺技術のいろは

    祖父江 慶太郎, 片山 直人, 岡田 卓也, 山口 雅人, 杉本 幸司

    第46回日本IVR学会総会, 2017年05月, 日本語, 日本IVR学会, 岡山, 国内会議

    公開講演,セミナー,チュートリアル,講習,講義等

  • Whole body FDG PET/MR for assessment of facet joint osteoarthritis: Direct comparison of FDG uptake with MR and CT features

    Munenobu Nogami, Shinsuke Shimoyama, Yuichi Wakabayashi, Utaru Tanaka, Yoshiaki Watanabe, Akihito Ohnishi, Tatsuya Nishii, Yoshiko Ueno, Keitaro Sofue, Atsushi K Kono, Kazuhiro Kubo, Satoru Takahashi, Kazuro Sugimura

    ISMRM 2017 annual Meeting, 2017年04月, 英語, International Society for Magnetic Resonance in Medicine, Honolulu, USA, Hybrid PET/MRI scanner is an emerging modality and utilized not only for oncological or neurological purposes but also for assessment of musculoskeletal disease. Simultaneous acquisition of PET and MRI enables precise anatomical localization of PET trace, 国際会議

    [招待有り]

    ポスター発表

  • Quantitative Estimation of Liver Function using Gadoxetic Acid-Enhanced MR Imaging: in Vitro and in Vivo Comparison between R1 and R2* Relaxometry.

    Sofue K, Tsurusaki M, Murakami T, Kyotani K, Ueda Y, Okuaki T, Takahasi S, Mustafa RB, Sugimura K

    25th ISMRM Annual Meeting, 2017年04月, 英語, International Society of Magnetic Resonance Medicine, Honolulu, USA, 国際会議

    [招待有り]

    ポスター発表

  • Estimation of Lobar Liver Function using Gadoxetic Acid-Enhanced MR Imaging: Comparison with 99mTc-GSA SPECT Imaging.

    Sofue K, Tsurusaki M, Murakami T, Kitajima K, Yamaguchi M, Sugimoto K, Tanaka U, Takahashi S, Sugimura K

    26th ISMRM Annual Meeting, 2017年04月, 英語, International Society of Magnetic Resonance Medicine, Honolulu, USA, 国際会議

    [招待有り]

    ポスター発表

  • Embolization for spontaneous adrenal hemorrhage.

    Gentsu T, Okada T, Katayama N, Tani R, Ueshima E, Koide Y, Sofue K, Yamaguchi M, Sugimoto K

    Cardiovascular and Interventional Radiological Society of Europe, 2016年09月, 英語, Cardiovascular and Interventional Radiological Society of Europe, Barcelona, Spain, 国際会議

    [招待有り]

    口頭発表(一般)

  • Combination therapy using denosumab and transarterial embolization for symptomatic sacral giant cell tumor.

    Tani R, Okada T, Gentsu T, Katayama N, Ueshima E, Koide Y, Sofue K, Yamaguchi M, Sugimoto K

    Cardiovascular and Interventional Radiological Society of Europe, 2016年09月, 英語, Cardiovascular and Interventional Radiological Society of Europe, Barcelona, Spain, 国際会議

    [招待有り]

    口頭発表(一般)

  • 膵神経内分泌腫瘍;CTにおける造影パターンと臨床病理学的所見の相関

    水本 拓也, 祖父江 慶太郎, 外山 博近, 後藤 直大, 田中 基文, 浅利 貞毅, 木戸 正浩, 味木 徹夫

    第71回日本消化器外科学会総会, 2016年07月, 日本語, 徳島大学, 徳島, 国内会議

    [招待有り]

    ポスター発表

  • ブタ肝後面下大静脈損傷モデルを用いたステントグラフトによる止血効果の検討

    井戸口 孝二, 山口 雅人, 片山 直人, 岡田 卓也, 上嶋 英介, 祖父江 慶太郎, 井芹 俊恵, 林 聡恵, 三重 慧一郎, 水島 靖明, 杉本 幸司

    日本インターベンショナルラジオロジー学会総会, 2016年05月, 日本語, 日本インターベンショナルラジオロジー学会, 名古屋, 国内会議

    [招待有り]

    口頭発表(一般)

  • ビーズ導入後のTACEの現状 多発肝細胞癌に対する非選択的DEB-TACEの有用性の検討

    岡田 卓也, 谷 龍一郎, 元津 倫幸, 片山 直人, 上嶋 英介, 小出 裕, 祖父江 慶太郎, 山口 雅人, 杉本 幸司

    日本インターベンショナルラジオロジー学会総会, 2016年05月, 日本語, 日本インターベンショナルラジオロジー学会, 名古屋, 国内会議

    [招待有り]

    口頭発表(一般)

  • Angiographic classification of uterine artery may predict failure of UAE for postpartum hemorrhage

    Sugimoto K, Ueshima E, Yamaguchi M, Okada T, Muradi A, Katayama N, Koide Y, Sofue K

    The 12th Asia-Pacific Congress of Cardiovascular and Interventional Radiology, 2016年04月, 英語, Asia-Pacific society of Cardiovascular and Interventional Radiology, Suzhou, CHINA, 国際会議

    [招待有り]

    口頭発表(一般)

  • Single-Energy Metal Artifact Reduction Algorithm: Utility for Improvements of Image Quality on Dynamic Contrast-enhanced CT in Patients who Underwent Surgical or Endvascular Treatment for Hepatocellular Carcinoma

    Keitaro Sofue, Takeshi Yoshikawa, Yoshiharu Ohno, Noriyuki Negi, Hiroyasu Inokawa, Naoki Sugihara, Sumiaki Matsumoto, Masato Yamaguchi, Koji Sugimoto, Kazuro Sugimura

    101st Radiological Society of North America, 2015年11月, 英語, Radiological Society of North America, Chicago, United States, 国際会議

    [招待有り]

    口頭発表(一般)

  • Natural Progression of Liver Imaging Reporting and Data System Category 4 (LI-RADS 4) Nodules in the Cirrhotic Liver: Risk Factors Predicting Upgrade to Definite Hepatocellular Carcinoma

    Keitaro Sofue, Lauren M, B. Burke, Madavi Alagiyawanna, Viragi Nilmini, Andrew J. Muir, Kingshuk R. Choudhury, Richard, C. Semelka, Mustafa R. Bashir

    101st Radiological Society of North America, 2015年11月, 英語, Radiological Society of North America, Chicago, United States, 国際会議

    [招待有り]

    ポスター発表

  • Fast Advanced Spin Echo Diffusion-Weighted Imaging in the Abdomen.

    Takeshi Yoshikawa, Katsusuke Kyotani, Yoshiharu Ohno, Yoshimori Kassai, Hisanobu Koyama, Keitaro Sofue, Kouya Nishiyama, Kazuro Sugimura

    101st Annual Meeting of Radiological Society of North America, 2015年11月, 英語, Radiological Society of North America, Chicago, USA, 国際会議

    [招待有り]

    ポスター発表

  • 上腹部FASE-DWIの検討

    吉川 武, 京谷 勉輔, 大野 良治, 葛西 由守, 神山久信, 祖父江 慶太郎, 西山 甲野, 杉村 和朗

    第43回日本磁気共鳴医学会大会, 2015年09月, 日本語, 日本磁気共鳴医学会, 東京, 国内会議

    [招待有り]

    口頭発表(一般)

  • 上腹部Computed DWIの検討

    吉川 武, 大野 良治, 京谷 勉輔, 葛西 由守, 神山 久信, 祖父江 慶太郎, 西山 甲野, 杉村 和朗

    第43回日本磁気共鳴医学会大会, 2015年09月, 日本語, 日本磁気共鳴医学会, 東京, 国内会議

    [招待有り]

    ポスター発表

  • 4D-PCA法による肝血管の描出能評価と血行力学的評価の初期経験

    吉川 武, 京谷 勉輔, 大野 良治, 神山 久信, 関 紳一郎, 西山 甲野, 祖父江 慶太郎, 杉村 和朗

    第43回日本磁気共鳴医学会大会, 2015年09月, 日本語, 日本磁気共鳴医学会, 東京, 国内会議

    [招待有り]

    口頭発表(一般)

  • Time-SLIP Non-Contrast MR Hepatic Arteriography: Comparison with Contrast-Enhanced CT Arteriography.

    Takeshi Yoshikawa, Yoshiharu Ohno, Katsusuke Kyotani, Saori Sato, Yoshimori Kassai, Hisanobu Koyama, Keitaro Sofue, Kazuro Sugimura

    23rd Scientific Meeting and Exhibition of International Society for Magnetic Resonance in Medicine, 2015年05月, 英語, International Society for Magnetic Resonance in Medicine, Toronto, Canada, 国際会議

    [招待有り]

    ポスター発表

  • Repeatability of MRI-based Liver Fat and Iron Quantification using a Multistep Adaptive Fitting Algorithm

    Keitaro Sofue, Xiaodong Zhong, Marcel Dominik Nickel, Brian Marshall Dale, Mustafa Rifaat Bashir

    23rd International Society of Magnetic Resonance in Medicine, 2015年05月, 英語, Society of Magnetic Resonance in Medicine, Toronto, Canada, 国際会議

    [招待有り]

    ポスター発表

  • 肝細胞癌術前のダイナミックCT:腫瘍診断とCTA の両立を意図したボーラストラッキング法の最適化

    吉川 武, 根宜 典行, 大野 良治, 祖父江 慶太郎, 杉原 直樹, 香川 清澄, 竹本 洋太, 村上 徹, 神山 久信, 杉村 和朗

    第74回日本医学放射線学会学術集会, 2015年04月, 日本語, 日本医学放射線学会, 横浜, 国内会議

    [招待有り]

    口頭発表(一般)

  • 3T装置を用いた上腹部Computed DWI

    吉川 武, 大野 良治, 京谷 勉輔, 葛西 由守, 祖父江 慶太郎, 神山 久信, 杉村 和朗

    第74回日本医学放射線学会学術集会, 2015年04月, 日本語, 日本医学放射線学会, 横浜, 国内会議

    [招待有り]

    口頭発表(一般)

  • 3T装置を用いたTime-SLIP法肝動脈MRA:造影CTAとの比較

    吉川 武, 大野 良治, 京谷 勉輔, 佐藤 さおり, 葛西 由守, 神山久信, 祖父江 慶太郎, 杉村 和朗

    第74回日本医学放射線学会学術集会, 2015年04月, 日本語, 日本医学放射線学会, 横浜, 国内会議

    [招待有り]

    口頭発表(一般)

  • Pretreatment CT Assessment of Patients with Hepatocellular Carcinoma: Optimization of Bolus Tracking Technique for Tumor Diagnosis and Visualization of Artery.

    Takeshi Yoshikawa, Noriyuki Negi, Yoshiharu Ohno, Keitaro Sofue, Naoki Sugihara, Tohru Murakami, Kiyosumi Kagawa, Hisanobu Koyama, Kazuro Sugimura

    Annual Meeting of European Congress of Radiology 2015, 2015年03月, 英語, European Congress of Radiology, Vienna, Austria, 国際会議

    [招待有り]

    ポスター発表

  • Evaluation of Time-SLIP Non-Contrast MR Hepatic Arteriography in Comparison with Contrast-Enhanced CT Arteriography.

    Takeshi Yoshikawa, Yoshiharu Ohno, Katsusuke Kyotani, Satou Saori, Yoshimori Kassai, Hisanobu Koyama, Keitaro Sofue, Kazuro Sugimura

    Annual Meeting of European Congress of Radiology 2015, 2015年03月, 英語, European Congress of Radiology, Vienna, Austria, 国際会議

    [招待有り]

    ポスター発表

  • Abdominal Computed Diffusion-Weighted Images at 3T-MRI.

    Takeshi Yoshikawa, Yoshiharu Ohno, Katsusuke Kyotani, Yoshimori Kassai, Keitaro Sofue, Hisanobu Koyama, Kazuro Sugimura

    Annual Meeting of European Congress of Radiology 2015, 2015年03月, 英語, European Congress of Radiology, Vienna, Austria, 国際会議

    [招待有り]

    ポスター発表

  • 当院における薬剤溶出性球状塞栓物質を用いたTACE(DEB-TACE)の初期経験

    片山 直人, 岡田 卓也, Muradi Akhmadu, 上嶋 英介, 小出 裕, 祖父江慶太郎, 山口 雅人, 杉本 幸司

    第60回関西IVR研究会, 2015年, 日本語, 日本IVR学会, 大阪, 国内会議

    口頭発表(一般)

  • 3T装置を用いた上腹部Computed DWI.

    吉川 武, 大野良治, 京谷勉輔, 葛西由守, 西尾瑞穂, 神山久信, 祖父江慶太郎, 杉村和朗

    第42回日本磁気共鳴医学会大会, 2014年09月, 日本語, 日本磁気共鳴医学会, 京都, 国内会議

    [招待有り]

    口頭発表(一般)

  • 3T装置を用いたTime-SLIP 法肝動脈MRA:造影CTAとの比較.

    吉川 武, 京谷勉輔, 大野良治, 佐藤さおり, 葛西由守, 神山久信, 祖父江慶太郎, 西尾瑞穂, 杉村和朗

    第42回日本磁気共鳴医学会大会, 2014年09月, 日本語, 日本磁気共鳴医学会, 京都, 国内会議

    [招待有り]

    口頭発表(一般)

  • Time-SLIP MR hepatic Arteriography using 3T-MRI.

    Keitaro Sofue, Takeshi Yoshikawa, Nobukazu Aoyama, Yoshiharu Ohno, Katsusuke Kyotani, Satou Saori, Naoki Kanata, Mizuho Nishio, Hisanobu Koyama, Kazuro Sugimura

    22nd Scientific Meeting and Exhibition of International Society for Magnetic Resonance in Medicine & Joint Annual Meeting ISMRM-ESMRMB 2014, 2014年05月, 英語, International Society for Magnetic Resonance in Medicine, Milan, Italy, 国際会議

    [招待有り]

    ポスター発表

  • Optimization of Scan Interval in Abdominal CT Perfusion.

    Takeshi Yoshikawa, Tomonori Kanda, Yoshiharu Ohno, Yasuko Fujisawa, Hisanobu Koyama, Mizuho Nishio, Tohru Murakami, Noriyuki Negi, Keitaro Sofue, Kazuro Sugimura

    第73回日本医学放射線学会総会, 2014年04月, 英語, 日本医学放射線学会, 横浜, 国内会議

    [招待有り]

    口頭発表(一般)

  • Optimization of Contrast Enhancement Technique in Abdominal CT Perfusion.

    Takeshi Yoshikawa, Tomonori Kanda, Yoshiharu Ohno, Yasuko Fujisawa, Tohru Murakami, Noriyuki Negi, Mizuho Nishio, Hisanobu Koyama, Keitaro Sofue, Kazuro Sugimura

    第73回日本医学放射線学会総会, 2014年04月, 英語, 日本医学放射線学会, 横浜, 国内会議

    [招待有り]

    口頭発表(一般)

  • Computed Diffusion-Weighted Image in the Abdomen: Initial Experience.

    Takeshi Yoshikawa, Nobukazu Aoyama, Yoshiharu Ohno, Katsusuke Kyotani, Tokunori Kimura, Yoshimori Kassai, Keitaro Sofue, Mizuho Nishio, Hisanobu Koyama, Kazuro Sugimura

    第73回日本医学放射線学会総会, 2014年04月, 英語, 日本医学放射線学会, 横浜, 国内会議

    [招待有り]

    口頭発表(一般)

  • Abdominal CT Perfusion: Effects of Breath Control Technique.

    Takeshi Yoshikawa, Tomonori Kanda, Yoshiharu Ohno, Yasuko Fujisawa, Noriyuki Negi, Tohru Murakami, Mizuho Nishio, Hisanobu Koyama, Keitaro Sofue, Kazuro Sugimura

    第73回日本医学放射線学会総会, 2014年04月, 英語, 日本医学放射線学会, 横浜, 国内会議

    [招待有り]

    口頭発表(一般)

  • T-SLIP MR Hepatic Arteriography at 3T.

    Takeshi Yoshikawa, Nobukazu Aoyama, Katsusuke Kyotani, Yoshiharu Ohno, Keitaro Sofue, Saori Satou, Mizuho Nishio, Hisanobu Koyama, Kazuro Sugimura

    Annual Meeting of European Congress of Radiology 2014, 2014年03月, 英語, European Congress of Radiology, Vienna, Austria, 国際会議

    [招待有り]

    ポスター発表

  • Optimization of Scan Interval in Abdominal CT Perfusion.

    Tomonori Kanda, Takeshi Yoshikawa, Yoshiharu Ohno, Yasuko Fujisawa, Hisanobu Koyama, Mizuho Nishio, Tohru Murakami, Keitaro Sofue, Kazuro Sugimura

    Annual Meeting of European Congress of Radiology 2014, 2014年03月, 英語, European Congress of Radiology, Vienna, Austria, 国際会議

    [招待有り]

    ポスター発表

  • Optimization of Contrast Enhancement Technique in Abdominal CT Perfusion.

    Tomonori Kanda, Takeshi Yoshikawa, Yoshiharu Ohno, Yasuko Fujisawa, Noriyuki Negi, Tohru Murakami, Keitaro Sofue, Hisanobu Koyama, Kazuro Sugimura

    Annual Meeting of European Congress of Radiology 2014, 2014年03月, 英語, European Congress of Radiology, Vienna, Austria, 国際会議

    [招待有り]

    ポスター発表

  • Optimization of Bolus Tracking Technique in Abdominal Dual-Arterial Multi-Phasic CT for Arteriography and Tumor Diagnosis.

    Noriyuki Negi, Takeshi Yoshikawa, Yoshiharu Ohno, Naoki Kanata, Keitaro Sofue, Kiyosumi Kagawa, Naoki Sugihara, Tohru Murakami, Kazuro Sugimura

    Annual Meeting of European Congress of Radiology 2014, 2014年03月, 英語, European Congress of Radiology, Vienna, Austria, 国際会議

    [招待有り]

    ポスター発表

  • Computed Diffusion-Weighted Image in the Abdomen.

    Takeshi Yoshikawa, Nobukazu Aoyama, Yoshiharu Ohno, Katsusuke Kyotani, Yoshimori Kassai, Keitaro Sofue, Mizuho Nishio, Hisanobu Koyama, Kazuro Sugimura

    Annual Meeting of European Congress of Radiology 2014, 2014年03月, 英語, European Congress of Radiology, Vienna, Austria, 国際会議

    [招待有り]

    ポスター発表

  • Abdominal CT with Single-Energy Metal Artifact Reduction (SEMAR): Initial Experiences.

    Keitaro Sofue, Takeshi Yoshikawa, Noriyuki Negi, Yoshiharu Ohno, Naoki Sugihara, Tohru Murakami, Hisanobu Koyama, Mizuho Nishio, Kazuro Sugimura

    Annual Meeting of European Congress of Radiology 2014, 2014年03月, 英語, European Congress of Radiology, Vienna, Austria, 国際会議

    [招待有り]

    ポスター発表

  • Abdominal CT with Single-Energy Metal Artifact Reduction (SEMAR): Initial Experiences

    Keitaro Sofue, Takeshi Yoshikawa, Negi Noriyuki, Yoshiharu Ohno, Naoki Sugihara, Toru Murakami, Hisanobu Koyama, Mizuho Nishio, Kazuro Sugimura

    European Congress of Radiology, 2014年03月, 英語, European Society of Radiology, Vienna, Austria, 国際会議

    [招待有り]

    ポスター発表

  • Abdominal CT Perfusion: Effects of Breath Control Technique.

    Takeshi Yoshikawa, Tomonori Kanda, Yoshiharu Ohno, Yasuko Fujisawa, Noriyuki Negi, Mizuho Nishio, Hisanobu Koyama, Keitaro Sofue, Kazuro Sugimura

    Annual Meeting of European Congress of Radiology 2014, 2014年03月, 英語, European Congress of Radiology, Vienna, Austria, 国際会議

    [招待有り]

    ポスター発表

  • 当院における非外傷性特発性後腹膜出血に対する動脈塞栓術の検討

    片山 直人, 祖父江 慶太郎, Muradi Akhmadu, 上嶋 英介, 岡田 卓也, 井戸口 孝二, 山口 雅人, 杉本 幸司

    第59回関西IVR研究会, 2014年, 日本語, 日本IVR学会, 大阪, 国内会議

    口頭発表(一般)

  • 巨細胞動脈炎の関与が疑われる両側上腕動脈病変に対しPTAを施行した2例

    上嶋 英介, 山口 雅人, 井戸口 孝二, 祖父江 慶太郎, 岡田 卓也, 片山 直人, Muradi Akhmadu, 杉本 幸司

    第58回関西IVR研究会, 2014年, 日本語, 日本IVR学会, 大阪, 国内会議

    口頭発表(一般)

  • Non-contrast MR Hepatic Arteriography Using T-SLIP at 3T.

    Keitaro Sofue, Takeshi Yoshikawa, Nobukazu Aoyama, Katsusuke Kyotani, Yoshiharu Ohno, Yoshimori Kassai, Saori Satou, Naoki Kanata, Tomonori Kanda, Hisanobu Koyama, Mizuho Nishio, Kazuro Sugimura

    The 99th Radiological Society of North America, Scientific Assembly and Annual Meeting., 2013年12月, 英語, Radiological Society of North America, Chicago, USA, 国際会議

    [招待有り]

    ポスター発表

  • Optimization of Contrast Medium Administration in CT Perfusion in the Abdomen.

    Tomonori Kanda, Takeshi Yoshikawa, Keitaro Sofue, Yoshiharu Ohno, Yasuko Fujisawa, Tohru Murakami, Mizuho Nishio, Hisanobu Koyama, Naoki Kanata, Noriyuki Negi, Kazuro Sugimura

    99th Annual Meeting of Radiological Society of North America, 2013年11月, 英語, Radiological Society of North America, Chicago, USA, 国際会議

    [招待有り]

    ポスター発表

  • Optimization of Acquisition Interval in Abdominal CT Perfusion Measurement.

    Tomonori Kanda, Takeshi Yoshikawa, Keitaro Sofue, Yoshiharu Ohno, Yasuko Fujisawa, Hisanobu Koyama, Mizuho Nishio, Noriyuki Negi, Tohru Murakami, Naoki Kanata, Kazuro Sugimura

    99th Annual Meeting of Radiological Society of North America, 2013年11月, 英語, Radiological Society of North America, Chicago, USA, 国際会議

    [招待有り]

    ポスター発表

  • Non-contrast MR Hepatic Arteriography Using T-SLIP at 3T.

    Keitaro Sofue, Takeshi Yoshikawa, Nobukazu Aoyama, Katsusuke Kyotani, Yoshiharu Ohno, Yoshimori Kassai, Saori Satou, Naoki Kanata, Tomonori Kanda, Hisanobu Koyama, Mizuho Nishio, Kazuro Sugimura

    99th Annual Meeting of Radiological Society of North America, 2013年11月, 英語, Radiological Society of North America, Chicago, USA, 国際会議

    [招待有り]

    ポスター発表

  • Abdominal CT Perfusion: Breathhold or Free Breathing?

    Takeshi Yoshikawa, Tomonori Kanda, Yoshiharu Ohno, Keitaro Sofue, Noriyuki Negi, Yasuko Fujisawa, Tohru Murakami, Hisanobu Koyama, Mizuho Nishio, Naoki Kanata, Kazuro Sugimura

    99th Annual Meeting of Radiological Society of North America, 2013年11月, 英語, Radiological Society of North America, Chicago, USA, 国際会議

    [招待有り]

    ポスター発表

  • 3T 装置を用いた上腹部computed DWI の初期的検討.

    吉川 武, 青山 信和, 大野 良治, 京谷 勉輔, 木村 徳典, 葛西 由守, 金田 直樹, 祖父江 慶太郎, 神山 久信, 西尾 瑞穂, 杉村 和朗

    第41回日本磁気共鳴医学会大会, 2013年09月, 日本語, 日本磁気共鳴医学会, 徳島, 国内会議

    [招待有り]

    口頭発表(一般)

  • 3T 装置を用いたTime-SLIP 法肝動脈MRA.

    吉川 武, 青山 信和, 大野 良治, 京谷 勉輔, 佐藤 さおり, 金田 直樹, 祖父江 慶太郎, 神山 久信, 西尾 瑞穂, 杉村 和朗

    第41回日本磁気共鳴医学会大会, 2013年09月, 日本語, 日本磁気共鳴医学会, 徳島, 国内会議

    [招待有り]

    口頭発表(一般)

  • 腹腔動脈起始部狭窄に伴う下膵十二指腸動脈瘤破裂に対するTAE後に十二指腸狭窄をきたした1例

    祖父江慶太郎, 山口雅人, 井戸口孝二, 岡田卓也, 上嶋英介, Akhmadu Muradi, 片山直人, 杉本幸司

    関西IVR地方会, 2013年06月, 日本語, 関西IVR学会, 大阪, 国内会議

    [招待有り]

    口頭発表(一般)

  • 鎖骨下静脈からの中心静脈カテーテル挿入に伴う胸肩峰動脈損傷に対して動脈塞栓術を施行した2例

    祖父江慶太郎, 山口雅人, 坂本憲昭, 奥野晃章, 井戸口孝二, 上嶋英介, 杉本幸司, 川崎竜太

    日本IVR学会第33回関西地方会, 2013年02月, 日本語, 日本IVR学会, 大阪, 国内会議

    [招待有り]

    口頭発表(一般)

  • Successful balloon-occluded retrograde transvenous obliteration (BRTO) with cyanoacrylate under temporary portal venous occlusion for duodenal varices.

    祖父江慶太郎, 荒井保明, 竹内義人, 芝本健太郎, 中村智行, 芝奈津子

    Cardiovascular Interventional Radiology Society of Europe, 2012年09月, 英語, Society of Cardiovascular Interventional Radiology Society of Europe, Lisbon, Portugal, 国際会議

    [招待有り]

    ポスター発表

  • Life-threatening brain edema caused by acute occlusion of superior vena cava stent.

    祖父江慶太郎, 荒井保明, 竹内義人, 芝本健太郎, 中村智行, 芝奈津子

    Cardiovascular Interventional Radiology Society of Europe, 2012年09月, 英語, Society of Cardiovascular Interventional Radiology Society of Europe, Lisbon, Portugal, 国際会議

    [招待有り]

    ポスター発表

  • Safety and efficacy of primary metallic biliary stent placement with tract embolization in patients with massive ascites.

    祖父江慶太郎, 荒井保明, 竹内義人, 芝本健太郎, 中村智行, 芝奈津子, 橋本林太郎

    The 10th Asian-Pacific Congress of Cardiovascular and Interventional Radiology, 2012年05月, 英語, Asian-Pacific Congress of Cardiovascular and Interventional Radiology, Kobe, 国際会議

    [招待有り]

    口頭発表(一般)

  • 短絡路作成のためのコアキシャル穿刺針の考案

    坂本憲昭, 荒井保明, 竹内義人, 高橋正秀, 藤原寛康, 祖父江慶太郎, 徳江浩之

    第39回日本IVR学会総会, 2010年05月, 日本語, 日本IVR学会, 東京, 国内会議

    [招待有り]

    口頭発表(一般)

  • A case of hemangiopericytoma in the retroperitoneum

    Keitaro Sofue

    Asiancongressofabdominalradiology, 2007年06月, 英語, Asian congress of abdominal radiology, 宮崎, 国際会議

    [招待有り]

    ポスター発表

共同研究・競争的資金等の研究課題

  • 門脈血流・肝機能定量MRIによる分離門脈血流・肝機能評価の検討

    小松 昇平, 村上 卓道, 福本 巧, 祖父江 慶太郎

    日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C), 神戸大学, 2021年04月 - 2024年03月, 研究分担者

  • 肝動脈塞栓術後のガン微小環境におけるマクロファージ極性制御に基づく新規治療戦略

    上嶋 英介, 平田 豊, 児玉 大志, 祖父江 慶太郎, 村上 卓道

    日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C), 神戸大学, 2020年04月 - 2023年03月, 研究分担者

  • ヨードマップを用いた膵癌の線維性間質定量による悪性度および治療抵抗性の予測法確立

    祖父江 慶太郎, 村上 卓道, 上嶋 英介, 上野 嘉子, 増田 充弘

    日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C), 神戸大学, 2019年04月 - 2022年03月, 研究代表者

    本研究の目的はDual-Energy CTで撮像したダイナミック造影CTから得られるヨードマップを用いて膵癌内部の線維性間質の多寡を定量測定することにより、非侵襲的に膵癌の悪性度ならびに治療抵抗性の予測を行うことである. 最終目的の前の先行研究として、膵癌線維化マーカーであるCollagen fiberならびに活性化膵星細胞と予後との関連を後方視的に評価した。2008年から2017年の間に神戸大学病院において膵癌に対して手術加療が行われた通常型膵管癌162症例に対してCollagen量を評価するEVG染色、活性化膵星細胞を評価するα-SMA染色を行った。それぞれの全体における染色割合をPhotoshopで算出し、その多寡で予後を評価した所、Collagen fiberが高度な膵癌は軽度な膵癌と比較して生存率が有意に延長(Log-rank test P=0.001)、α-SMA陽性細胞が高度の膵癌は軽度な膵癌と比較して生存率が有意に延長していた(Log-rank test P=0.001)。また線維化高度な膵癌では腫瘍内のCD8陽性T細胞が多いことも判明した。この結果から、膵癌においては線維化が高度な症例で予後が良く、腫瘍内免疫状態とも関連している可能性が示唆された。 続いて、上記対象162膵癌に対して造影CT平衡相画像から線維化を予測可能かを評価した。線維化予測指標としてECV fractionを利用して18例において評価を行った所、ECV fractionとCollagen fiberの程度に中等度の相関が見られたが(ρ=0.641、P=0.034)、α-SMA陽性細胞との程度には相関は認められなかった(ρ=0.352、P=0.289)。造影CT平衡相における評価は検討症例数を増やすとともに、ヒストグラム解析の追加を検討している。 また、Dual-Energy CTを用いた膵癌線維性間質の評価を行うための研究に対して倫理委委員会の承認が得られ、実施体制を整えることができた。

  • 血流・組織解析CTによる肝細胞癌分子標的療法の治療効果および肝不全予測法の確立

    村上 卓道, 鶴崎 正勝, 祖父江 慶太郎

    日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C), 神戸大学, 2019年04月 - 2022年03月, 研究分担者

    本研究の目的は、Dual-Energy CTの組織物質弁別画像による血流・組織解析法を用い て肝細胞癌に対する分子標的薬の治療効果ならびに背景肝実質への影響を同時に評価する ことである。 進行肝細胞癌に対してレンバチニブ投与予定の患者に対して、当院にて配備されているDual-Energy CT装置(Siemens社SOMATOM Force)を用いて治療前7日以内、治療後1ヶ月、2ヶ月後にダイナミック造影CTを施行した19名に対して画像評価を行った。撮像条件として、ファントム実験でヨード定量の安定性が高かった100kVと150SnkVの管電圧、reference mAs 240mAsの組み合わせで撮像を行った。ダイナミック造影CTとして体重あたり600mgIの造影剤を30秒間で静脈注入し、動脈相・門脈相・平衡相の撮像を行った。 mRECISTで治療効果判定を行ったところ、1ヶ月後・2ヶ月後の奏効率はそれぞれ21%・37%であり、過去文献での奏効率40.6%と近い値を示した。一方でChoi criteriaで評価を行った場合には奏効率は47%・47%と上昇しており、mRECISTでの評価よりも早期に奏効が得られる症例が増えており、内部血流低下を鋭敏に検知できていることが証明された。また、動脈相のヨードマップで腫瘍内部のCT値を測定すると治療前36.9に対して1ヶ月後28.2、2ヶ月後19.6と減少していた。 上記の結果から、少数例での検討ではあるがヨードマップで肝細胞癌内部のヨード値を測定することでレンバチニブの治療効果である腫瘍新生血管の阻害効果を適切に評価できることが示唆された。

  • ヨード密度CT画像を用いた肝線維化の評価法の開発

    鶴崎 正勝, 村上 卓道, 兵頭 朋子, 祖父江 慶太郎

    日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C), 近畿大学, 2017年04月 - 2021年03月, 研究分担者

    ボランティア実験、臨床例の検討のため施設倫理委員会の承認が得られた。 (1)ヒトによるヨード密度値の定量測定と最適なパラメーターの確立のため、正常肝を有するボランティア患者10 名および,生検にて組織学的に肝線維化が評価されたウイルス性慢性肝炎・肝硬変を有する臨床患者に対して,DECTによる造影ダイナミックCT撮像を行いデータ収集を行なった。慢性肝炎(組織学的な線維化スコアF0-3),肝硬変(F4)患者それぞれ30 名(計60名)を目標としたが、集積終了した。CT撮像は通常の臨床で行われる撮像方法に従い,各相でのヨード密度画像を作成し,ヨード密度をROIにて測定する. そのデータをもとに,肝線維化と関連のあるパラメーターを探索する. 現在のところ、以下のようにヨード停滞率(residual ratio)が良好なパラメーターである可能性が分かっている。 検討方法:線維化スコアF0からF4までの各群と肝実質のヨード[水]密度を比較検討した。結果:単純、門脈相、平衡相での肝実質のヨード[水]密度を順にIn、Ip、Ieとすると、(Ie-In)-(Ip-In)=Ie-Ip(門脈相から平衡相の密度の傾き)は、F0, -9.4±2.0; F1, -10.2±1.6; F2, -8.4±1.7; F3, -7.5±2.8; F4, -3.9±3.5であり、Ie-Ipと線維化スコアとの間に有意な相関がみられた(r=0.699, p<0.001)。また、cutoffを-4.0にした場合のF0-3とF4の弁別の感度は80%、特異度は93.9%であった。この結果の学会、論文発表を行った。

  • 神緑会研究助成金

    祖父江 慶太郎

    一般社団法人神緑会, 2016年06月 - 2017年03月, 研究代表者

    競争的資金

  • 山口 雅人, 上嶋 英介, 岡田 卓也, 杉本 幸司, 祖父江 慶太郎, 片山 直人

    日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C), 神戸大学, 2016年04月 - 2019年03月, 研究分担者

    本研究はウサギ腫瘍モデルに対する炭酸飽和水動注療法の抗腫瘍効果および抗癌剤(シスプラチン)の増感作用を検討することを企図したものである。 肝臓に腫瘍(VX2)を移植した日本白ウサギ40羽に対して、移植後3週に肝動脈まで挿入したカテーテルより炭酸ガス飽和水を注入した。対象をコントロール群、炭酸群、シスプラチン群、混合群の4群に分け、注入3日目、7日目に造影CTでの腫瘍体積を計測を行い、7日目に安楽死後、低酸素やアポトーシスの評価を行った。 結果は炭酸群、混合群で腫瘍増大効果の抑制がみられ、炭酸関連の2群では低酸素、アポトーシスの誘導が認められた。さらに混合群ではシスプラチン増感作用が示唆された。

    競争的資金

  • 祖父江 慶太郎, 村上 卓道, 鶴崎 正勝

    日本学術振興会, 科学研究費助成事業 若手研究(B), 若手研究(B), 神戸大学, 2015年04月 - 2019年03月, 研究代表者

    MRIによる肝の脂肪定量の際に同時に得られるR2*値を利用してGd-EOB-DTPA造影剤の取り込みを定量・数値化できるかどうかの研究を行った. ファントム実験においてはR2*値による造影剤定量は,R1値による造影剤定量とほぼ同等の定量精度が得られることが分かった.臨床研究においては血液生化学的な指標であるMELD scoreやICG 15分停滞率との相関が得られ,R2*値による肝機能定量の有用性が示唆された.一方で,画質の安定性が悪く特に肝左葉では計測値に信頼性が乏しいこと,背景肝実質への過剰鉄沈着例においては定量ができないことが判明し,R2* mapでの肝機能定量における限界と考えられた.

    競争的資金

  • 村上 卓道, 鶴崎 正勝, 兵頭 朋子, 祖父江 慶太郎

    日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C), 2014年04月 - 2019年03月, 研究分担者

    Dual Energy CT(DECT)は、異なるエネルギーのX線データを用いて、そのX吸収値の変化から特定の物質を分別できる可能性がある。本研究では、肝硬変、脂肪肝、NASHなどの病変に現れる特定の物質や投与薬剤の病変内への到達量を定量測定できるDECTによる複合物質分別処理技術(MMD: Multi Material Decomposition)を開発した。これにより、肝細胞癌リスクと関係する肝の脂肪沈着、線維化の程度や、シスプラチンなどの金属を含む抗がん剤の腫瘍到達量を定量的に診断できる非侵襲的早期肝疾患診断技術(仮想CT肝生検)を可能とした。

  • 吉川 武, 村瀬 研也, 大野 良治, 神山 久信, 松本 純明, 西尾 瑞穂, 祖父江 慶太郎, 杉村 和朗, 村瀬 研也

    日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C), 神戸大学, 2014年04月 - 2017年03月, 研究分担者

    ボランティアでの血流量・流速は妥当と考えられ、せん断応力(WSS,OSI,SWSSG,GON)は大血管で高値となり動静門脈を分離可能であった。 肝疾患28症、他24例では、流量・流速は低下、せん断応力は動脈で個人差が増大した。脈管判別能はせん断応力が優れた。Gd併用が有用であった。疾患群でSMA血流の低下、SMAのOSI、SPA・PVのGON上昇と門脈流速低下、胆管障害例で肝動脈血流増加がみられた。Child-Pughスコアの上昇に伴い腹腔動脈系のせん断応力上昇、門脈血流量減少、肝静脈GONの低下がみられた。解析は約40分程度であった。 血管性状変化の解明と機能評価における有用性が示された。

    競争的資金

  • 山口 雅人, 上嶋 英介, 杉本 幸司, 祖父江 慶太郎

    日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C), 神戸大学, 2013年04月01日 - 2016年03月31日

    炭酸ガス溶解液の抗腫瘍効果を調べるため、ウサギVX2腫瘍大腿移植モデルを使用し、炭酸ガス溶解液を経動脈的に注入した。炭酸ガス注入群とコントロール群に分け、腫瘍サイズの変化およびアポトーシス誘導の比較を行った。腫瘍サイズは造影CT、アポトーシスの評価はTUNEL染色およびcaspase-3によるウエスタンブロッティングを用いて行った。炭酸ガス注入群で、腫瘍増大率が有意に低く、アポトーシスの発現が有意に高かった。炭酸ガスの動脈注射によりCaspase-3を介したアポトーシスを生じ、VX2腫瘍サイズの増大が抑制されることが示された。

    競争的資金

  • 井戸口 孝二, 山口 雅人, 祖父江 慶太郎, 杉本 幸司, 岡田 卓也, 上嶋 英介, 井芹 俊恵, 林 聡恵, 三重 慧一郎, 臼井 亮介, 山田 茉美, 比良 英二

    日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C), 神戸大学, 2013年04月 - 2016年03月, 研究分担者

    外傷性肝後面下大静脈損傷に対する新しい血管内治療法の開発を目的として、本研究を行った。まず最初に、ブタを用いて新しいバルーンカテーテルの開発実験を行ったが、有効な下大静脈灌流が得られず、形状の変更を余儀なくされた。第二段階として、これまでに報告のないブタ肝後面下大静脈損傷モデルの作成に成功した。 引き続き、同損傷モデルに対して血管内治療による止血が可能か否かを検証したところ、ステントグラフトによる止血効果を確認し得た。そこで、ステントグラフトと同等の止血効果を有し、かつ抜去可能な新しいデバイスの開発を進めた。現在デバイス改良の最終段階に入っており、追加実験を行い、早期の完成を目指している。

    競争的資金

  • 杉本 幸司, 山口 雅人, 祖父江 慶太郎

    日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C), 神戸大学, 2013年04月 - 2016年03月, 研究分担者

    我々は、以前に血管内治療手技を用いてブタにおける急性B型大動脈解離モデルを作成することに成功し、研究成果を報告している。今回の研究では、より安定した偽腔開存型の急性B型大動脈解離モデルを作成することを検討し、慢性期経過観察も行い、解離性大動脈瘤モデルの作成を検討した。急性期解離においては従来より安定したモデルが作成できた。慢性期では6頭のうち3頭で径の拡大を認め、解離性大動脈瘤モデルとして期待できるものであった。解離性大動脈瘤モデルを低侵襲な手技で作成できたることは、今後の本疾患に対しての治療的な研究を遂行していく上で、多大な貢献をすることができると考える。

    競争的資金

  • 第10回日本医学放射線学会 バイエル研究助成

    祖父江 慶太郎

    日本医学放射線学会, 2013年04月 - 2014年03月, 研究代表者

    競争的資金