研究者紹介システム

明石 昌也
アカシ マサヤ
大学院医学研究科 医科学専攻
教授
医学
Last Updated :2022/08/04

研究者情報

所属

  • 【主配置】

    大学院医学研究科 医科学専攻
  • 【配置】

    医学部 医学科, 医学部附属病院 歯科口腔外科

学位

  • 博士(医学), 神戸大学

授業科目

  • 臨床医学講義3(歯科口腔外科), 医学部 医学科, 2021

ジャンル

  • 医療・健康 / 臨床医学
  • 医療・健康 / がん治療

コメントテーマ

  • 口腔外科
  • 頭頚部がん
  • 口腔がん
  • 顎関節症
  • 味覚障害
  • インプラント

研究活動

研究分野

  • ライフサイエンス / 外科系歯学

論文

  • Sakiko Soutome, Souichi Yanamoto, Mika Nishii, Yuka Kojima, Takumi Hasegawa, Madoka Funahara, Masaya Akashi, Toshiyuki Saito, Masahiro Umeda

    Background/purpose: Radiotherapy for head and neck cancer often causes severe oral mucositis. The purpose of this retrospective study was to further examine the risk factors for developing severe oral mucositis in patients with oral cancer undergoing radiotherapy as a compliment to a previous study performed by our group. Materials and methods: A total of 181 patients with oral cancer undergoing radiotherapy were enrolled in the study. The association between a number of potential risk factors and grade 3 oral mucositis were analyzed using the cox proportional hazard model and a logistic regression analysis. Results: Grade 3 oral mucositis occurred in 56 patients. The cox proportional hazard model analysis revealed that those with lower hemoglobin levels, concurrent cisplatin and cetuximab administration, and a larger number of teeth showed a significantly higher incidence of severe oral mucositis. Logistic regression analysis revealed that patients who had lower hemoglobin levels, received concurrent cisplatin or cetuximab treatment, and were not administered pilocarpine showed a significantly higher incidence of severe oral mucositis. The presence of teeth may stimulate the oral mucosa and become a risk factor for mucositis, and the administration of pilocarpine might reduce the risk. Conclusion: This study describes the risk factors of severe radiation-induced oral mucositis in oral cancer patients and shows the possibility of risk reduction by pilocarpine. This information could help patients avoid painful mucositis.

    2021年10月, Journal of Dental Sciences, 16 (4), 1241 - 1246

    研究論文(学術雑誌)

  • 皮膚充填材への感染により生じた頬部蜂窩織炎の1例

    榎本 由依, 橘 進彰, 格谷 僚, 岩田 英治, 高田 直樹, 明石 昌也

    (公社)日本口腔外科学会, 2021年07月, 日本口腔外科学会雑誌, 67 (7), 447 - 451, 日本語

  • Manabu Shigeoka, Yu-ichiro Koma, Takayuki Kodama, Mari Nishio, Masaya Akashi, Hiroshi Yokozaki

    BackgroundCD163-positive macrophages contribute to the aggressiveness of oral squamous cell carcinoma. We showed in a previous report that CD163-positive macrophages infiltrated not only to the cancer nest but also to its surrounding epithelium, depending on the presence of stromal invasion in tongue carcinogenesis. However, the role of intraepithelial macrophages in tongue carcinogenesis remains unclear. In this study, we assessed the biological behavior of intraepithelial macrophages on their interaction with cancer cells. Materials and MethodsWe established the indirect coculture system (intraepithelial neoplasia model) and direct coculture system (invasive cancer model) of human monocytic leukemia cell line THP-1-derived CD163-positive macrophages with SCC25, a tongue squamous cell carcinoma (TSCC) cell line. Conditioned media (CM) harvested from these systems were analyzed using cytokine array and enzyme-linked immunosorbent assay and extracted a specific upregulated cytokine in CM from the direct coculture system (direct CM). The correlation of both this cytokine and its receptor with various clinicopathological factors were evaluated based on immunohistochemistry using clinical samples from 59 patients with TSCC. Moreover, the effect of this cytokine in direct CM on the phenotypic alterations of THP-1 was confirmed by real-time polymerase chain reaction, western blotting, immunofluorescence, and transwell migration assay. ResultsIt was shown that CCL20 was induced in the direct CM specifically. Interestingly, CCL20 was produced primarily in SCC25. The expression level of CCR6, which is a sole receptor of CCL20, was higher than the expression level of SCC25. Our immunohistochemical investigation showed that CCL20 and CCR6 expression was associated with lymphatic vessel invasion and the number of CD163-positive macrophages. Recombinant human CCL20 induced the CD163 expression and promoted migration of THP-1. We also confirmed that a neutralizing anti-CCL20 antibody blocked the induction of CD163 expression by direct CM in THP-1. Moreover, ERK1/2 phosphorylation was associated with the CCL20-driven induction of CD163 expression in THP-1. ConclusionsTongue cancer cell-derived CCL20 that was induced by interaction with macrophages promotes CD163 expression on macrophages.

    Frontiers Media SA, 2021年06月09日, Frontiers in Oncology, 11

    研究論文(学術雑誌)

  • T Hasegawa, N Ueda, S I Yamada, S Kato, E Iwata, S Hayashida, Y Kojima, M Shinohara, I Tojo, H Nakahara, T Yamaguchi, T Kirita, H Kurita, Y Shibuya, S Soutome, M Akashi

    Pre-existing inflammation, corticosteroid therapy, periapical periodontitis, longer duration of denosumab therapy, and female sex were significantly associated with an increased risk of denosumab-related osteonecrosis of the jaw after tooth extraction in patients with cancer on oncologic doses of denosumab. A short drug holiday did not protect against this complication. INTRODUCTION: This study retrospectively investigated the relationship between various risk factors, including brief discontinuation of denosumab, and development of denosumab-related osteonecrosis of the jaw (DRONJ) after tooth extraction in patients with cancer who were receiving oncologic doses of this agent. METHODS: Data were collected on demographic characteristics, duration of denosumab therapy, whether or not denosumab was discontinued before tooth extraction (drug holiday), duration of discontinuation, presence of pre-existing inflammation, and whether or not additional surgical procedures were performed. Risk factors for DRONJ after tooth extraction were evaluated by univariate and multivariate analyses. RESULTS: A total of 136 dental extractions were performed in 72 patients (31 men, 41 women) with cancer who were receiving oncologic doses of denosumab. Post-extraction DRONJ was diagnosed in 39 teeth (28.7%) in 25 patients. Tooth extraction was significantly associated with development of DRONJ only in patients with pre-existing inflammation (odds ratio [OR] 243.77), those on corticosteroid therapy (OR 73.50), those with periapical periodontitis (OR 14.13), those who had been taking oncologic doses of denosumab for a longer period (OR 4.69), and in women (OR 1.04). There was no significant difference in the occurrence of DRONJ between patients who had a drug holiday before tooth extraction and those who did not. CONCLUSIONS: These findings suggest that inflamed teeth should be extracted immediately in patients with cancer who are receiving oncologic doses of denosumab. Drug holidays have no significant impact on the risk of DRONJ.

    2021年05月17日, Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 英語, 国際誌

    研究論文(学術雑誌)

  • Manabu Shigeoka, Yu-ichiro Koma, Mari Nishio, Masaya Akashi, Hiroshi Yokozaki

    <b><i>Background:</i></b> The mortality of oral squamous cell carcinoma (OSCC) has remained high for decades; therefore, methods for early detection of OSCC are warranted. However, in the oral cavity, various mucosal diseases may be encountered, including reactive lesions and oral potentially malignant disorders, and it is difficult to differentiate OSCC from these lesions based on both clinical and histopathological findings. It is well known that chronic inflammation contributes to oral cancer development. Macrophages are among the most common inflammatory cells in cancer stromal tissue and have various roles in cancer aggressiveness. Although the roles of macrophages in cancer development have attracted attention, only a few studies have linked macrophages to carcinogenesis, particularly, oral precancerous lesions. <b><i>Summary:</i></b> This review article consists of 3 parts: first, we summarize current knowledge on macrophages in human various epithelial precancerous lesions, excluding the oral cavity, to show the importance and gaps in knowledge regarding macrophages in carcinogenesis; second, we review published data related to the role of macrophages in oral carcinogenesis; finally, we present a novel view on oral carcinogenesis, focusing on crosstalk between epithelial cells and macrophages. <b><i>Key Messages:</i></b> The biological features of macrophages in oral carcinogenesis differ drastically depending on the anatomical compartment that they infiltrate. Focusing on the alteration of macrophage infiltrating compartment may serve as a useful novel approach for studying the role of the macrophages in oral carcinogenesis and for gaining further insight into cancer prevention and early detection.

    S. Karger AG, 2021年05月07日, Pathobiology, 1 - 11

    研究論文(学術雑誌)

  • 口腔・中咽頭癌放射線治療326例における重症口腔粘膜炎および口腔カンジダ症発症に関連する因子

    西井 美佳, 五月女 さき子, 岩田 英治, 長谷川 巧実, 兒島 由佳, 船原 まどか, 梅田 正博, 明石 昌也

    (一社)日本口腔ケア学会, 2021年04月, 日本口腔ケア学会雑誌, 15 (3), 145 - 145, 日本語

  • Izumi Saito, Takumi Hasegawa, Yumiko Kawashita, Shinichiro Kato, Shin-Ichi Yamada, Yuka Kojima, Nobuhiro Ueda, Masahiro Umeda, Yasuyuki Shibuya, Hiroshi Kurita, Tadaaki Kirita, Masaya Akashi

    OBJECTIVE: Radiotherapy (RT) carries a substantial risk for the development of osteoradionecrosis (ORN) of the jaw. This study was performed to investigate the relationship between dental extractions after RT and the development of ORN. MATERIAL AND METHODS: Thirty-two patients with head and neck cancer who underwent tooth extraction after RT were investigated for correlations between the development of ORN and various factors. RESULTS: Postextraction ORN was diagnosed in 12 (12.1%) teeth of 9 patients. The RT dose against the site of tooth extraction was 62.0 and 37.4 Gy in the ORN and Non-ORN groups, respectively (p < .001). The duration from RT to tooth extraction was 41.2 and 28.2 months in the ORN and Non-ORN groups, respectively (p = .025). Tooth extraction was significantly associated with ORN in patients with a high RT dose against the site (odds ratio = 1.231) and a longer duration of time from RT (odds ratio = 1.084). CONCLUSIONS: Extraction of non-restorable teeth and those with a poor prognosis should not necessarily be postponed even when patients are undergoing RT. However, clinicians should pay special attention to postoperative management after tooth extraction in patients with a high RT dose and longer time from RT.

    2021年03月01日, Oral diseases, 英語, 国際誌

    研究論文(学術雑誌)

  • Eiji Iwata, Takumi Hasegawa, Masaki Kobayashi, Akira Tachibana, Naoki Takata, Toshiya Oko, Daisuke Takeda, Yoshiki Ishida, Tsuyoshi Fujita, Ikuko Goto, Junichiro Takeuchi, Masaya Akashi

    PURPOSE: In maxillary wisdom tooth extraction, the necessity of CT is unknown. The purpose of this study was to investigate whether CT adding to orthopantomography is useful for predicting oroantral perforation during maxillary third molar extraction. METHODS: Various risk factors for oroantral perforation during maxillary third molar extraction were investigated by univariate and multivariate analyses. We analyzed those of all patients and the patients who underwent CT, respectively. The proximity of the roots to the maxillary sinus floor (root-sinus [RS] classification) and Archer classification were assessed using panoramic radiography. The number of roots and vertical relationship were assessed using CT. RESULTS: A total of 604 out of 3299 patients underwent CT adding to orthopantomography. In all cases, multivariate analyses except for CT findings showed that the RS classification type III/IV and the Archer classification Type B/C/D in panoramic findings were significantly correlated with oroantral perforation as radiological findings. In cases for which CT was performed, multivariate analyses showed that one root (OR 12.87) and the vertical relationship Type D (OR 5.63) in CT findings, besides the RS classification type III/IV (OR 4.47) in panoramic findings, were significantly related to oroantral perforation. CONCLUSION: The RS classification and the Archer classification in panoramic findings can predict the risk of oroantral perforation. The usefulness of CT adding to orthopantomography is limited. However, when the relationship between the upper wisdom tooth and maxillary sinus floor (RS classification) is unclear, to check whether the number of roots is one and the apex of one root is projecting into the maxillary sinus in CT findings, is useful for the prediction.

    2021年03月, Oral and maxillofacial surgery, 25 (1), 7 - 17, 英語, 国際誌

    研究論文(学術雑誌)

  • Masato Ogawa, Seimi Satomi-Kobayashi, Naofumi Yoshida, Yasunori Tsuboi, Kodai Komaki, Nagisa Nanba, Kazuhiro P. Izawa, Takeshi Inoue, Yoshitada Sakai, Masaya Akashi, Ken ichi Hirata, Kenji Okada

    Background: Poor oral health status can lead to a deteriorated level of general health and is common among patients undergoing cardiovascular surgery. However, the effect of oral health status on postoperative outcomes in cardiovascular surgery patients remains unclear. Thus, we investigated the effect of preoperative oral health status on postoperative complications and functional recovery after cardiovascular surgery. Methods: This single-centre retrospective cohort study included 884 inpatients undergoing elective cardiovascular surgery. Oral health status was assessed based on the number of remaining teeth, use of dentures, occlusal support, and periodontal status. We investigated postoperative complications related to surgery and postoperative functional recovery by measuring the reacquisition of walking ability, activities of daily living, and length of postoperative hospital stay. Results: In this cohort (age 66.9 ± 13.4 years), the mean number of remaining teeth was 18.7 ± 9.4. Patients were grouped based on tertiles of the data distribution of remaining teeth: ≥ 20 teeth (470 patients); 10-19 teeth (137 patients); < 10 teeth (185 patients). The number of missing teeth was associated with age (P < 0.001). The prevalence of postoperative pneumonia and reintubation after surgery was 3.2% and 2.5%, respectively, which was significantly higher in patients with severe tooth loss (P < 0.05 for both). After adjusting for age and other confounding factors, the number of remaining teeth was a statistically significant predictor of functional recovery (P < 0.05). Conclusions: Preoperative oral health status was related to postoperative respiratory complications and independently associated with functional recovery. Preoperative oral intervention may improve functional recovery after cardiovascular surgery.

    2021年03月, CJC Open, 3 (3), 276 - 284

    研究論文(学術雑誌)

  • Masato Ogawa, Seimi Satomi-Kobayashi, Naofumi Yoshida, Yasunori Tsuboi, Kodai Komaki, Nagisa Nanba, Kazuhiro P Izawa, Yoshitada Sakai, Masaya Akashi, Ken-Ichi Hirata

    BACKGROUND: Oral health is important for maintaining general health and is associated with components of physical frailty among the elderly. Oral health problems are common in hospitalized patients; however, no reports on oral health problems pertain to patients with cardiovascular diseases (CVD). The present study aimed to evaluate the association between oral health and physical frailty in these patients. METHODS: In this retrospective cohort study, we included consecutive patients admitted for CVD to our hospital between May 2014 and December 2018. Physical frailty was assessed using the Short Physical Performance Battery (SPPB). Oral health characteristics, such as the number of remaining teeth, denture use, occlusal support, and periodontal status, were assessed. RESULTS: In our cohort (n = 457), 111 (24.3%) patients had physical frailty. Univariate linear regression showed that the number of teeth present and the prevalence of occlusal support were significantly lower in patients with than without physical frailty. Pearson correlation indicated that the number of teeth significantly correlated with the nutritional status (r = 0.27) and SPPB score (r = 0.24), grip strength (r = 0.33), and 6-minute walking distance (r = 0.26). Multiple linear regression analysis showed that the number of teeth was independently associated with physical frailty after adjusting for confounders. CONCLUSIONS: Oral health was closely associated with physical frailty, and nutritional status in patients with CVD; thus, it could be an important screening marker for early frailty symptoms and a predictor of future malnutrition risk.

    2021年02月, Journal of cardiology, 77 (2), 131 - 138, 英語, 国際誌

    研究論文(学術雑誌)

  • Takumi Hasegawa, Daisuke Takeda, Motofumi Tanaka, Rika Amano, Izumi Saito, Yasumasa Kakei, Akira Kimoto, Takumi Fukumoto, Masaya Akashi

    PURPOSE: This study retrospectively investigated relationships among risk factors and post-hepatectomy surgical site infection (SSI) and other complications in patients who underwent hepatectomy for hepatocellular carcinoma (HCC). METHODS: We included 334 patients who underwent hepatectomies for liver cancers between January 2011 and December 2015 in this study. We evaluated risk factors for SSI and other post-hepatectomy complication, including demographic factors, preoperative factors, and preoperative intervention including oral management, perioperative factors, and length of hospital stay, with univariate and multivariate analyses. The oral management intervention included self-care instructions, extraction of infected teeth, removal of dental plaques and calculus (scaling), professional mechanical teeth cleaning, removal of tongue coating, and cleaning of dentures. SSI was defined in accordance with the guideline issued by the Centers for Disease Control and Prevention; it included purulent discharge from any incision or organ space within 30 days postoperatively, with or without microbiological evidence. Complications of grade II or greater, according to the Clavien-Dindo classification, were regarded as postoperative complications. RESULTS: We found bacterial infection of ascites (Odds ratio (OR) = 13.72), lack of preoperative oral management intervention (OR = 10.17), and severe liver fibrosis (OR = 2.76) to be associated with SSI and severe liver fibrosis (OR = 2.28), hypoalbuminemia (OR = 2.02), blood transfusion (OR = 1.86), and longer operation time (OR = 1.80) to be associated with postoperative complications. CONCLUSIONS: Preoperative oral management may reduce the risk of SSI in patients with HCC who undergo hepatectomy.

    2021年02月, Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 29 (2), 653 - 659, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Takumi Hasegawa, Erina Kobayashi, Rika Amano, Izumi Saito, Daisuke Takeda, Yasumasa Kakei, Akira Kimoto, Akiko Sakakibara, Masaya Akashi

    Purpose Recurrence in oral squamous cell carcinoma (OSCC) is not rare. Due to lack of studies assessing characteristics of recurrent OSCC, including time to recurrence and outcomes, we sought to investigate its characteristics, time to recurrence, and outcomes in Japanese OSCC patients. Methods This study was a nonrandomized retrospective cohort study in a tertiary referral centre. It included 208 (117 men and 91 women) patients with recurrent oral cancer who underwent major curative surgery in the Department of Oral and Maxillofacial Surgery at Kobe University Hospital between January 1999 and April 2017. The outcomes were disease-specific survival (DSS) and overall survival (OS). Results In multivariable Cox proportional hazards analysis, the time to recurrence (hazard ratio [HR] 3.55, 95% confidence interval [CI] 1.69-6.63; P = 0.001), extranodal extension (ENE, HR 2.72, 95% CI 1.51-4.89; P = 0.001), and high T stage (HR 2.00, 95% CI 1.01-3.97; P = 0.046) were independent predictors of DSS. The time to recurrence (HR 3.29, 95% CI 1.82-5.96; P < 0.001) and ENE (HR 2.64, 95% CI 1.52-4.56; P = 0.001) were independent predictors of OS. Conclusion Time to recurrence, extranodal extension, and higher T stage were independent prognosis predictors in OSCC.

    SPRINGER INDIA, 2021年02月, JOURNAL OF MAXILLOFACIAL & ORAL SURGERY, 英語

    研究論文(学術雑誌)

  • Takumi Hasegawa, Nanae Yatagai, Tatsuya Furukawa, Emi Wakui, Izumi Saito, Daisuke Takeda, Yasumasa Kakei, Akiko Sakakibara, Ken-Ichi Nibu, Masaya Akashi

    BACKGROUND: This prospective study investigated the change of swallowing ability using the Swallowing Ability Scale System (SASS) and swallowing-related quality of life (QOL) by Performance Status Scale for Head and Neck Cancer patients (PSS-H&N). This study also investigated the risk factors for postoperative dysphagia in patients who received reconstructive surgery for oral cancer. SUBJECTS AND METHODS: This study included 64 patients (33 men and 31 women) who underwent radical surgery with neck dissection and reconstructive surgery for oral cancers between July 2014 and February 2018. We evaluated risk factors for poor swallowing ability after treatment, including demographic factors, preoperative factors and perioperative factors, with univariate and multivariate analyses. The change of swallowing ability by the SASS and swallowing-related QOL by PSS-H&N were evaluated prospectively prior to the initiation of surgery within 1 week and at 1 and 3 months after treatment. RESULTS: Advanced T stage (T3, 4) (odds ratio (OR) = 79.71), bilateral neck dissection (OR = 20.66) and the resection of unilateral or bilateral suprahyoid muscles (OR = 17.00) were associated with poor swallowing ability after treatment. The scores for time for food intake and Eating in Public were associated with decrease of QOL in the poor group. CONCLUSIONS: We propose that clinicians consider the risk factors identified in this study and pay close attention to the management of oral cancer patients with reconstructive surgery.

    2021年01月25日, Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale, 50 (1), 4 - 4, 英語, 国際誌

    研究論文(学術雑誌)

  • Junya Kusumoto, Atsushi Uda, Takeshi Kimura, Shungo Furudoi, Ryosuke Yoshii, Megumi Matsumura, Takayuki Miyara, Masaya Akashi

    BACKGROUND: In Japan, oral third-generation cephalosporins with broad-spectrum activity are commonly prescribed in the practices of dentistry and oral surgery. However, there are few reports on the appropriate use of antibiotics in the field of oral surgery. This study aimed to evaluate the appropriateness of antibiotic use before and after an educational intervention in the Department of Oral and Maxillofacial Surgery, Kobe University Hospital. METHODS: The use of oral antibiotics was investigated among inpatients and outpatients before and after an educational intervention conducted by the antimicrobial stewardship team. Additionally, the frequency of surgical site infection after the surgical removal of an impacted third mandibular molar under general anesthesia and the prevalence of adverse effects of the prescribed antibiotics were comparatively evaluated between 2013 and 2018. RESULTS: After the educational intervention, a remarkable reduction was noted in the prescription of oral third-generation cephalosporins, but increased use of penicillins was noted among outpatients. There was reduced use of macrolides and quinolones in outpatients. Although a similar trend was seen for inpatients, the use of quinolones increased in this population. Despite the change in the pattern of antibiotic prescription, inpatients who underwent mandibular third molar extraction between 2013 and 2018 did not show a significant increase in the prevalence of surgical site infections (6.2% vs. 1.8%, p = .336) and adverse effects of drugs (2.1% vs. 0%, p = .466). CONCLUSIONS: This study suggests that the judicious use of oral antibiotics is possible through conscious and habitual practice of appropriate antibiotic use. However, further investigation is required to develop measures for appropriate use of oral antibiotics.

    2021年01月07日, BMC oral health, 21 (1), 20 - 20, 英語, 国際誌

    研究論文(学術雑誌)

  • Hikaru Kubota, Daisuke Miyawaki, Naritoshi Mukumoto, Takeaki Ishihara, Megumi Matsumura, Takumi Hasegawa, Masaya Akashi, Naomi Kiyota, Hirotaka Shinomiya, Masanori Teshima, Ken-Ichi Nibu, Ryohei Sasaki

    BACKGROUND: To evaluate factors associated with osteoradionecrosis of the jaw (ORNJ) in patients with head and neck squamous cell carcinoma (HNSCC), focusing on jaw-related dose-volume histogram (DVH) parameters. METHODS: We retrospectively reviewed the medical records of 616 patients with HNSCC treated with curative-intent or postoperative radiation therapy (RT) during 2008-2018. Patient-related (age, sex, history of smoking or alcohol use, diabetes mellitus, performance status, pre-RT dental evaluation, pre- or post-RT tooth extraction), tumor-related (primary tumor site, T-stage, nodal status), and treatment-related (pre-RT surgery, pre-RT mandible surgery, induction or concurrent chemotherapy, RT technique) variables and DVH parameters (relative volumes of the jaw exposed to doses of 10 Gy-70 Gy [V10-70]) were investigated and compared between patients with and without ORNJ. The Mann-Whitney U test was used to compare RT dose parameters. Univariate and multivariate Cox regression analyses were used to assess factors associated with ORNJ development. Kaplan-Meier analyses were performed for cumulative ORNJ incidence estimation. RESULTS: Forty-six patients (7.5%) developed ORNJ. The median follow-up duration was 40 (range 3-145) months. The median time to ORNJ development was 27 (range 2-127) months. DVH analysis revealed that V30-V70 values were significantly higher in patients with than in those without ORNJ. In univariate analyses, primary tumor site, pre-RT mandible surgery, post-RT tooth extraction, and V60 > 14% were identified as important factors. In multivariate analyses, V60 > 14% (p = 0.0065) and primary tumor site (p = 0.0059) remained significant. The 3-year cumulative ORNJ incidence rates were 2.5% and 8.6% in patients with V60 ≤ 14% and > 14%, respectively (p < 0.0001), and 9.3% and 1.4% in patients with oropharyngeal or oral cancer and other cancers, respectively (p < 0.0001). CONCLUSIONS: V60 > 14% and oropharyngeal or oral cancer were found to be independent risk factors for ORNJ. These findings might be useful to minimize ORNJ incidence in HNSCC treated with curative RT.

    2021年01月05日, Radiation oncology (London, England), 16 (1), 1 - 1, 英語, 国際誌

    研究論文(学術雑誌)

  • Ryuichiro Funahara, Sakiko Soutome, Madoka Funahara, Shoma Tsuda, Takumi Hasegawa, Masahiro Umeda, Masaya Akashi

    Purpose: Serious oral mucositis develops during radiation therapy (RT) for head and neck cancer, but there is no effective preventive method. We have used a steroid ointment to prevent oral mucositis during RT, but the use of steroid ointment is discontinued when oral candidiasis develops. Therefore, prevention of oral candidiasis is important. The purpose of this study was to examine whether administration of a miconazole oral patch reduced the amount of Candida albicans in saliva and prevented the development of oral candidiasis during RT. Methods: Participants were patients with head and neck cancer receiving RT ≥ 60 Gy. Patients in the intervention group received miconazole oral patches for 14 days after the appearance of grade 2 oral mucositis. The control group received oral care only. Total bacteria and C. albicans counts in the saliva were analyzed by real-time polymerase chain reaction. The incidence of oral candidiasis was compared between the groups. Results: Total bacterial counts did not change throughout RT in either the intervention or the control group. However, C. albicans count significantly increased at 30 Gy and 60 Gy in the control group but was suppressed in the intervention group. The saliva pH did not show a significant change throughout RT in either group. The incidence of oral candidiasis in the intervention group tended to be lower than that in the control group. Conclusion: This study suggested that prophylactic use of a miconazole oral patch was effective in suppressing the growth of C. albicans count in saliva during RT for head and neck cancer.

    2021年, Supportive Care in Cancer

    研究論文(学術雑誌)

  • Wensu Huang, Masaya Akashi, Takuro Nishio, Noriyuki Negi, Akira Kimoto, Takumi Hasegawa

    INTRODUCTION: Elongated mandibular coronoid process is a rare condition defined as enlargement of the coronoid process. The only useful way to treat the mouth-opening limitation is resection of the elongated coronoid process. Four-dimensional CT (4DCT; three spatial dimensions plus time axis) is a novel imaging technique. Its usefulness of for evaluation of dynamic movements such as joint motion has been reported. Here, we show the potential usefulness of 4DCT evaluation in a patient with elongated mandibular coronoid process. CASE PRESENTATION: A 59-year-old female who suffered from mouth-opening difficulty and pressure during mouth opening was referred to our department. Elongation of the right coronoid process was evident in a panoramic X-ray image. The mandibular movement and temporal muscle motility before and after coronoidectomy in this patient on 4DCT could be evaluated. CONCLUSIONS: 4DCT is useful in the diagnosis and surgical outcome of elongated coronoid process.

    2020年12月, Oral and maxillofacial surgery, 24 (4), 515 - 520, 英語, 国際誌

    研究論文(学術雑誌)

  • Eiji Iwata, Akira Tachibana, Junya Kusumoto, Naoki Takata, Takumi Hasegawa, Masaya Akashi

    BACKGROUND: Various antibiotics and analgesics have been reported to interact with warfarin. Reports that investigate the effects of medication taken for just a few days during tooth extraction on the prothrombin time-international normalized ratio are rare. METHODS: A total of 110 patients receiving long-term stable warfarin therapy underwent tooth extraction without interruption of warfarin treatment. INR values were measured 1 month before the tooth extraction, the day of the extraction, and 1 week after the extraction. We investigated the changes in INR values between the day of extraction and 1 week after extraction, as well as the various risk factors for increases in INR values. RESULTS: Before and after tooth extraction, the number of patients taking cefcapene pivoxil, amoxicillin, and azithromycin was 57, 36, and 8, respectively. Nine patients were administered ampicillin before tooth extraction and received amoxicillin after their tooth extraction. One week after tooth extraction, the INR values increased beyond the therapeutic range in 3 out of 110 patients (2.7%). The INR values before tooth extraction in these three patients were close to 3.0. The INR value increased by more than twice as much in 1 out of 110 patients (0.9%). CONCLUSION: Our results suggest that prophylactic antibiotic administration has little effect on INR values when patients on stable warfarin therapy undergo tooth extraction. Surgeons have to take attention if the patients whose INR values are close to 3.0 before their extraction.

    2020年11月19日, BMC oral health, 20 (1), 331 - 331, 英語, 国際誌

    研究論文(学術雑誌)

  • 生体腎移植後患者に発症した歯性感染症によるガス壊疽の1例

    高田 直樹, 橘 進彰, 岩田 英治, 榎本 由依, 明石 昌也

    (一社)日本口腔感染症学会, 2020年11月, 日本口腔感染症学会雑誌, 27 (2), 61 - 66, 日本語

  • Manabu Shigeoka, Satomi Arimoto, Masaya Akashi

    Background: Junctional Cadherin 5 Associated (JCAD) is an endothelial, cell-cell junction protein, and its expression is associated with cardiovascular diseases including atherosclerosis and hypertension. However, to date, there are few studies confirming JCAD expression and precise localization in human tissues by immunohistochemical staining. Methods: JCAD expression and localization was assessed in four human submandibular gland (SMG) specimens by immunohistochemical staining. One specimen of SMG with sialoadenitis was accompanied by severe inflammation and fibrosis, while the other was largely normal. Other two SMGs were accompanied by severe fibrosis because of irradiation. Results: Immunohistochemical analysis of human SMGs revealed JCAD localization at the blood endothelial cell-cell junctions. JCAD expression was more evident in microvessels and arteries in areas affected by inflammation. Conclusions: The localization of JCAD at endothelial cell-cell junctions was confirmed in human tissues. JCAD expression may be affected by pathological conditions.

    2020年10月, Heliyon, 6 (10), e05121, 英語, 国際誌

    研究論文(学術雑誌)

  • 延原 浩, 五月女 さき子, 林田 咲, 梅田 正博, 長谷川 巧実, 明石 昌也, 山田 慎一, 栗田 浩, 中原 寛和, 上田 順宏, 桐田 忠昭, 中村 知寿, 渋谷 恭之, 山口 泰平, 森 和代

    (一社)日本外科感染症学会, 2020年10月, 日本外科感染症学会雑誌, 17 (5), 329 - 329, 日本語

  • Daiki Takahashi, Yusuke Demizu, Sung Chul Park, Yoshiro Matsuo, Nor Shazrina Sulaiman, Kazuki Terashima, Sunao Tokumaru, Masaya Akashi, Tomoaki Okimoto

    This study aimed to determine the maximum tolerance dose (MTD) and to estimate the recommended dose (RD) of concomitant S-1 with carbon-ion radiotherapy (RT) for sinonasal squamous cell carcinoma (SCC). Nine patients with sinonasal SCC received carbon-ion RT with escalating doses of S-1 according to phase I methods. Doses of 40, 60 and 80 mg/m2/day were administered twice daily in dose levels 1, 2 and 3, respectively, from days 1 to 14 and 22 to 35. Carbon-ion RT was administered at a dose of 70.4 Gy (relative biological effectiveness) in 32 fractions, 5 days a week. Two patients developed grade 3 acute dermatitis. However, none developed dose-limiting toxicities. Therefore, the MTD of S-1 could not be determined; the RD was estimated to be 80 mg/m2/day with concurrent carbon-ion RT. Partial response and stable disease were noted in 5 and 4 patients, respectively. The 2-year overall survival and local control rates were 56 and 74%, respectively. Overall, 2 patients developed ≥grade 3 late toxicities; among them, 1 patient developed grade 3 cataract and the other developed grade 4 cataract, optic nerve disorder and hearing impairment. To the best of our knowledge, this phase I study is the first clinical trial to evaluate concomitant S-1 with carbon-ion RT for sinonasal SCC. The MTD of S-1 could not be determined, and the RD was estimated to be 80 mg/m2/day. This study demonstrated a manageable safety profile for this combination. The observed outcomes may facilitate further evaluation of this novel therapy.

    2020年09月08日, Journal of radiation research, 61 (5), 733 - 739, 英語, 国際誌

    研究論文(学術雑誌)

  • Ryuichi Itoh, Shin ichi Yamada, Takumi Hasegawa, Nobuhiro Yamakawa, Yuya Denda, Hiroki Otagiri, Masaya Okura, Souichi Yanamoto, Masaya Akashi, Tadaaki Kirita, Yoshihide Ota, Masahiro Umeda, Hiroshi Kurita

    The aim of the present study was to review the treatment outcomes of oral sarcoma in Japan based on a multicenter retrospective analysis. Between January 2001 and December 2015, 30 patients were histologically diagnosed with sarcoma in the oral and maxillofacial regions and retrospectively reviewed. Osteosarcoma was the most common in 6 (20 %) out of 30 cases, followed by 3 cases (10 %) of fibrosarcoma. The average maximum size of the primary tumor was 42.3 ± 18.7 mm (range: 5−80 mm). The mandible was the most common site of the primary tumor and observed in 15 cases (50 %), followed by the maxilla in 12 cases (40 %). Soft tissue sarcoma was noted in 3 cases (10 %). The average follow-up period was 5.6 ± 4.6 years (range, 0.1–14.7 years). Five- and 10-year OS rates were 81.4 and 62.0 %, respectively. Five- and 10-year OS rates in cases that underwent radical surgery were 95.5 and 72.7 %, respectively, and were significantly higher than those treated with non-surgical therapy (p < 0.0001). The early detection and complete surgical resection of primary tumors with adequate surgical margins appears to be important for improving the prognosis of oral sarcoma patients.

    2020年09月, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, 32 (5), 356 - 359

    研究論文(学術雑誌)

  • Manabu Shigeoka, Yu-Ichiro Koma, Maki Kanzawa, Masaya Akashi, Hiroshi Yokozaki

    Oral lichenoid conditions (OLC), including oral lichen planus (OLP), oral lichenoid lesions and oral lichenoid dysplasia, differ in pathogenesis and biological malignancy. However, distinguishing them based on clinical or histological features is difficult. It is well known that CD163+ macrophages are associated with oral cancer aggressiveness. We recently demonstrated that CD163+ macrophages of noncancerous lesions infiltrate the stroma, not the intraepithelial area. In this report, we describe a case of OLC that was not detected as malignant by the first local biopsy. Furthermore, we evaluated the malignant potency of OLC by retrospectively comparing the histological findings between local biopsy and resected specimens focusing on CD163+ macrophages. A 72-year-old man with a white lesion in the unilateral buccal mucosa was diagnosed with OLP through the biopsy although invasive cancer was detected two years later. Intraepithelial CD163+ macrophages were found not only on the resected specimen but also biopsy. This is the first report to demonstrate that intraepithelial CD163+ macrophages may be noteworthy indicators to identify the malignant potency of OLC.

    MDPI AG, 2020年08月23日, Diagnostics (Basel, Switzerland), 10 (9), 624 - 624, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Takumi Sato, Junya Kusumoto, Daisuke Takeda, Megumi Kishimoto, Masahiko Kashin, Shungo Furudoi, Masaya Akashi

    OBJECTIVES: One of the treatment goals for osteonecrotic lesions of the jaw, such as medication-related osteonecrosis of the jaw (MRONJ) or osteoradionecrosis (ORN), is restoration of quality of life (QOL). This study aimed to identify symptoms that negatively affect QOL in patients with unhealed MRONJ or ORN. STUDY DESIGN: This cross-sectional study included patients who were previously diagnosed with MRONJ or ORN and who underwent treatment at the Kobe University Hospital between June 2015 and February 2016. Patient QOL was measured by using the Oral Health Impact Profile (OHIP-14). The predictor variable was disease status (stage and healing). The outcome variable was OHIP-14. One-way analysis of variance and Tukey's test were performed. RESULTS: The study included 74 patients (37 men and 37 women; mean age 70 years). Although there was no significant difference between the OHIP-14 scores of unhealed MRONJ and ORN (stages 1-3) and those of healed ones, the "worsened sense of taste" resulted in significant differences among stages in patients with unhealed MRONJ (P = .027) and the "painful mouth aching" in patients with unhealed ORN (P = .041). CONCLUSIONS: Worsened sense of taste and pain negatively affected QOL in patients with unhealed MRONJ and ORN.

    2020年08月, Oral surgery, oral medicine, oral pathology and oral radiology, 130 (2), 175 - 180, 英語, 国際誌

    研究論文(学術雑誌)

  • Shin-Ichi Yamada, Takumi Hasegawa, Sakiko Soutome, Hitoshi Yoshimura, Masaaki Miyakoshi, Nobuhiro Ueda, Kenjiro Okamoto, Sumiyo Hishida, Satoshi Rokutanda, Hirokazu Nakahara, Shigeyuki Fujita, Masaya Akashi, Yoshimasa Kitagawa, Tadaaki Kirita, Yasuyuki Shibuya, Masahiro Umeda, Hiroshi Kurita

    Postoperative hemorrhage after tooth extraction is a critical and clinically important issue for clinicians and patients receiving anticoagulants. The purpose of the present study was to investigate the prevalence of and risk factors for postoperative hemorrhage after lower third molar extraction in Japanese patients receiving warfarin therapy. A total of 142 patients who underwent lower third molar extraction between January 2010 and December 2016 were included, and their medical records were retrospectively reviewed. The prevalence of and risk factors for postoperative hemorrhage were investigated. The prevalence of postoperative hemorrhage after lower third molar extraction was significantly higher in patients receiving warfarin than in healthy subjects (21.8% vs 0.7%, P < 0.001). The cutoff value for PT-INR was 2.11 based on a receiver-operating characteristic analysis. A multivariate analysis indicated that an elevated PT-INR value [hazard ratio (HR) 3.798, 95% confidence interval (CI) 1.400-10.467, P < 0.01], preoperative antibiotic administration (HR 4.434, 95% CI 1.591-14.775, P < 0.01), difficulties with intraoperative hemostasis (HR 16.298, 95% CI 2.986-110.677, P < 0.01), and higher serum creatinine levels (HR 7.465, 95% CI 1.616-39.576, P < 0.05) are significant predictors of postoperative hemorrhage after lower third molar extraction. Multivariate correlations were observed between risk factors including an elevated PT-INR value, preoperative antibiotic administration, and higher serum creatinine levels, and postoperative hemorrhage after lower third molar extraction in patients receiving warfarin therapy. Clinicians need to consider these risk factors for postoperative hemorrhage after the lower third molar extraction and monitor PT-INR in patients receiving warfarin therapy.

    2020年07月, Odontology, 108 (3), 462 - 469, 英語, 国内誌

    [査読有り]

    研究論文(学術雑誌)

  • S. Yanamoto, Y. Denda, Y. Ota, T. Hasegawa, M. Akashi, M. Okura, S. I. Yamada, H. Kurita, N. Yamakawa, T. Kirita, M. Ueda, M. Umeda

    Extranodal extension (ENE) of lymph node metastasis and the presence of a positive or close margin (PCM) are major risk factors for head and neck squamous cell carcinoma recurrence. This retrospective multicentre cohort study compared the prognostic impact of postoperative radiotherapy (RT) and concurrent chemoradiotherapy (CCRT) in oral squamous cell carcinoma (OSCC) patients at high risk of recurrence. One hundred and eighteen patients with PCM and/or ENE who underwent definitive surgery plus either adjuvant RT or CCRT using cisplatin for OSCC were investigated. The cohort-wide 5-year loco-regional control (LRC), disease-free survival (DFS), and overall survival (OS) rates (the main outcome measures) were 54.3%, 35.8%, and 43.2%, respectively. Multivariate analysis showed that age ≥64 years (hazard ratio (HR) 0.584), cT3–4 stage (HR 1.927), ≥4 metastatic lymph nodes (HR 1.912), and PCM (HR 2.014) were significant independent predictors of OS. Moreover, postoperative CCRT with cisplatin was associated with a significantly improved LRC rate, but not with improved DFS or OS rates, compared to postoperative RT (HR 0.360). Given that CCRT with cisplatin does not significantly improve survival, additional clinical trials will be required to validate new regimens that further improve the outcomes of patients with loco-regionally advanced OSCC going forward.

    2020年07月, International Journal of Oral and Maxillofacial Surgery, 49 (7), 848 - 853

    研究論文(学術雑誌)

  • Takumi Hasegawa, Tomoya Iga, Daisuke Takeda, Rika Amano, Izumi Saito, Yasumasa Kakei, Junya Kusumoto, Akira Kimoto, Akiko Sakakibara, Masaya Akashi

    BACKGROUND: Prognostic biomarkers provide essential information about a patient's overall outcome. However, existing biomarkers are limited in terms of either sample collection, such as requiring tissue specimens, or the process, such as prolonged time for analysis. In view of the need for convenient and non-invasive prognostic biomarkers for oral cancer, we aimed to investigate the prognostic values of neutrophil-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, and platelet-to-lymphocyte ratio in patient survival. We also aimed to explore the associations of these ratios with the clinicopathologic characteristics of Japanese oral squamous cell carcinoma patients. METHODS: This study was a non-randomized retrospective cohort study in a tertiary referral center. We included 433 patients (246 men, 187 women) who underwent radical surgery for oral cancers between January 2001 and December 2013. We evaluated various risk factors for poor prognosis including neutrophil-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, and platelet-to-lymphocyte ratio with univariate and multivariate analyses. The disease-specific survival and overall survival rates of patients were compared among the factors and biomarkers. RESULTS: In multivariable Cox proportional hazards analysis, high neutrophil-to-lymphocyte ratio (hazard ratio 2.87, 95% confidence interval 1.59-5.19, P <  0.001), moderately or poorly differentiated histology (hazard ratio 2.37, 95% confidence interval 1.32-4.25, P <  0.001), and extranodal extension (hazard ratio 1.95, 95% confidence interval 1.13-3.35, P = 0.016) were independent predictors of disease-specific survival. High neutrophil-to-lymphocyte ratio (hazard ratio 2.30, 95% confidence interval 1.42-3.72, P <  0.001), moderately or poorly differentiated (hazard ratio 1.72, 95% confidence interval 1.07-2.76, P = 0.025), and extranodal extension (hazard ratio 1.79, 95% confidence interval 1.13-2.84, P = 0.013) were independent predictors of overall survival. CONCLUSIONS: Neutrophil-to-lymphocyte ratio might be a potential independent prognostic factor in Japanese oral squamous cell carcinoma patients.

    2020年06月17日, BMC cancer, 20 (1), 568 - 568, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Shin-Ichi Yamada, Takumi Hasegawa, Kohei Okuyama, Nobuhiro Yamakawa, Masaya Okura, Masao Hashidume, Souichi Yanamoto, Masaya Akashi, Tadaaki Kirita, Masahiro Umeda, Hiroshi Kurita

    OBJECTIVES: The present study investigated the clinical significance of the G8 screening tool in elderly oral squamous cell carcinoma (OSCC) patients using a multicenter analysis. MATERIALS AND METHODS: The medical records of 438 primary OSCC patients aged 75 years and older were retrospectively reviewed. To examine the clinical significance of the G8 screening tool in elderly OSCC patients, self-reliance (SR) rates and prognostic factors were statistically analyzed. RESULTS: The mean score of the G8 screening tool was 10.9 ± 2.93. The SR cut-off value of the G8 score was 9.5 in a receiver operating characteristic curve analysis. Five-year overall survival rates were 40.1% in patients with a G8 score < 9.5 and 58.4% in those with a G8 score ≥ 9.5 (p < 0.01). Five-year cancer-specific rates were 34.3% in patients with a G8 score < 9.5 and 55.7% in those with a G8 score ≥ 9.5 (p < 0.01). Five-year SR rates were 40.7% in patients with a G8 score < 9.5 and 55.3% in those with a G8 score ≥ 9.5 (p < 0.05). A multivariate analysis identified an advanced age (≥ 80 vs < 80; HR, 1.437; 95%CI, 1.181-1.843; p < 0.01), poorer ECOG-PS (2-4 vs 0-1; HR, 1.560; 95%CI, 1.14-2.106; p < 0.01), and standard treatment (non-standard therapy vs standard therapy; HR, 0.598; 95%CI, 0.405-0.910; p < 0.05) as significant independent prognostic factors for SR. A lower G8 score was associated with poorer SR (≥ 9.5 vs < 9.5; HR, 0.765; 95%CI, 0.575-1.034; p = 0.081). CONCLUSION: The clinical significance of the G8 score for elderly OSCC patients was demonstrated and its combination with ECOG-PS may be useful for assessing their prognoses.

    2020年06月, Clinical oral investigations, 24 (6), 1953 - 1961, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Yasumasa Kakei, Hirokazu Komatsu, Tsutomu Minamikawa, Takumi Hasegawa, Masanori Teshima, Hirotaka Shinomiya, Naoki Otsuki, Ken-Ichi Nibu, Masaya Akashi

    BACKGROUND: No clear consensus has been reached on the indication of supraomohyoid neck dissection (SOHND) for clinically positive lymph-node metastasis. PATIENTS: Consecutive 100 patients with previously untreated oral cancer treated at Kobe University Hospital were included in this study. All patients were clinically staged as anyTN1M0 and underwent radical dissection of the primary site and level I-V neck dissection as the initial treatment. RESULTS: None of the 100 patients had pathological lymph-node metastasis (pLN) to level V. pLN to level IV was observed in two patients with tongue cancer in whom clinical lymph-node metastasis was preoperatively observed at level II. CONCLUSIONS: Level V may be excluded in the neck dissection for patients with N1 oral cancers. Level IV dissection should be considered in the patient with tongue cancer and clinical lymph-node metastasis at level II.

    2020年06月, International journal of clinical oncology, 25 (6), 1067 - 1071, 英語, 国内誌

    [査読有り]

    研究論文(学術雑誌)

  • Manabu Shigeoka, Yu-Ichiro Koma, Takayuki Kodama, Mari Nishio, Masaya Akashi, Hiroshi Yokozaki

    OBJECTIVE: Oral leukoplakia has mixed and differing histopathological features, and it is thus difficult to reach an accurate histological diagnosis of oral leukoplakia based on a local biopsy alone. We recently demonstrated the significance of CD163+ macrophages in oral carcinogenesis. Herein we sought to determine whether CD163+ macrophages in biopsy specimens of oral leukoplakia help identify the overall histological nature of the lesion. PATIENTS AND METHODS: Twenty-six patients with tongue leukoplakia who underwent a histological examination by both a preoperative local biopsy and consecutive total excision were enrolled. We evaluated clinicopathological factors and the expression of CD163+ macrophages based on a retrospective comparison of the histological diagnostic concordance between the biopsies and excisions. RESULTS: Seventeen patients (diagnostic-agreement group) were diagnosed with squamous intraepithelial lesion based on both the biopsy and the excision. Nine patients (diagnostic-discrepancy group) were diagnosed with invasive cancer by excision, although invasive cancer was not observed in their biopsy specimens. Compared to the diagnostic-agreement group, the diagnostic-discrepancy group had more tongue leukoplakia with non-homogenous or high numbers of intraepithelial CD163+ macrophages. CONCLUSION: The evaluation of intraepithelial CD163+ macrophages in local biopsy specimens from tongue leukoplakia patients is a promising tool for cancer screening.

    2020年04月, Oral diseases, 26 (3), 527 - 536, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Mika Nishii, Sakiko Soutome, Akiko Kawakita, Hirokazu Yutori, Eiji Iwata, Masaya Akashi, Takumi Hasegawa, Yuka Kojima, Madoka Funahara, Masahiro Umeda, Takahide Komori

    PURPOSE: The present retrospective multicenter study intended to investigate the factors associated with severe oral mucositis and candidiasis in patients undergoing radiotherapy for oral and oropharyngeal carcinomas. METHODS: A total of 326 patients who underwent radiotherapy for oral and oropharyngeal cancers were enrolled in the study. The patients' age, sex, body mass index, primary site, diabetes, serum albumin, creatinine, hemoglobin, leukocyte and lymphocyte, concurrent cisplatin or cetuximab, method of radiation, total radiation dose, feeding route, use of spacers, pilocarpine hydrochloride, and corticosteroid ointment were examined, and the associations of each variable with oral mucositis and candidiasis were analyzed by multivariate Cox regression analysis. RESULTS: Grade 3 oral mucositis occurred in 136 (41.7%) patients. Male sex, oropharyngeal cancer, low hemoglobin levels, low leukocytes or lymphocytes, concurrent cisplatin or cetuximab, and oral feeding were found to be significantly associated with a higher incidence of severe oral mucositis. Oral candidiasis occurred in 101 (31.0%) patients. Oropharyngeal cancer, low leukocyte count, and oral mucositis of grade 2 or higher were found to be significantly associated with a higher incidence of oral candidiasis. The use of a topical steroid ointment was not found to be a risk factor for oral candidiasis. CONCLUSIONS: The present retrospective study demonstrated that certain factors may predispose patients with oral and oropharyngeal cancers receiving radiotherapy to develop severe oral mucositis and oral candidiasis. A preventive strategy for severe oral mucositis needs to be established in the future for high-risk cases.

    2020年03月, Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 28 (3), 1069 - 1075, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Susumu Miura, Tetsu Nakamura, Takumi Hasegawa, Yukiko Miura, Gosuke Takiguchi, Naoki Urakawa, Hiroshi Hasegawa, Masashi Yamamoto, Shingo Kanaji, Yoshiko Matsuda, Kimihiro Yamashita, Takeru Matsuda, Taro Oshikiri, Satoshi Suzuki, Masaya Akashi, Yoshihiro Kakeji

    BACKGROUND: Oral health is associated with various diseases, including cancer. Tooth loss is a simple and objective index of oral health. OBJECTIVE: The purpose of this study was to investigate the association between preoperative tooth loss and esophageal cancer prognosis after esophagectomy. METHODS: This study included 191 patients who underwent esophagectomy for esophageal cancer after perioperative dental evaluation and oral care at Kobe University Hospital from April 2011 to March 2016. Patients were divided into two groups: Group A (tooth loss < 7) and Group B (tooth loss ≥ 7). Three-year overall survival (OS) and multivariate analysis were performed, along with subgroup analysis for elderly patients (age ≥ 65 years). RESULTS: The 3-year OS rate was 68.1% in Group A (104 patients) and 49.2% in Group B (87 patients). Group A had significantly higher OS than Group B (p = 0.002), and there were no significant differences in sex and clinical T or N stage between the two groups. However, the mean age of Group A was younger than that of Group B (64.2 vs. 68.5 years; p = 0.0002). Among elderly patients, the 3-year OS rate was 68.2% in Group A (55 patients) and 45.1% in Group B (65 patients) [p = 0.003]. Multivariate analysis that included age demonstrated that tooth loss is an independent prognostic factor (hazard ratio 1.87, 95% confidence interval 1.22-2.87), in addition to clinical T stage and preoperative serum albumin. CONCLUSION: Tooth loss is an independent prognostic factor for esophageal cancer after esophagectomy.

    2020年03月, Annals of surgical oncology, 27 (3), 683 - 690, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Manabu Shigeoka, Yu-Ichiro Koma, Takayuki Kodama, Mari Nishio, Masaya Akashi, Hiroshi Yokozaki

    Oral verruciform xanthoma (OVX) is an uncommon benign lesion that is characterized histologically by the accumulation of several foamy macrophages in the lamina propria papillae. The pathogenesis of OVX has not been completely elucidated, although the significance of macrophage polarization (M1, tumor suppression; and M2, tumor promotion) and the contribution of M2 macrophages to angiogenesis are well established. This study investigated the role of foamy macrophages in OVX, with a focus on angiogenesis. Four patients who underwent surgical excision or total excisional biopsy for OVXs were enrolled in this study. We evaluated the expression of the macrophage markers CD68 (broad) and CD163 (M2) and the CD34-positive microvessel density (MVD) of OVXs. The foamy macrophages of all patients exhibited positivity to CD68 and CD163. We evaluated the MVD and the expression of the vascular endothelial growth factor (VEGF) based on histological architecture. The MVD of all OVX cases was significantly higher than that of the corresponding normal epithelia. Interestingly, the MVD of verrucous-type OVX cases was higher than that of the other type. VEGF was expressed on foamy macrophages in all cases. Overall, the foamy macrophages expressing CD163 were associated with the morphogenesis of OVX through the process of angiogenesis by VEGF expression.

    2020年02月14日, Dentistry journal, 8 (1), 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Masahiko Kashin, Yasumasa Kakei, Shun Teraoka, Takumi Hasegawa, Akinobu Yamaguchi, Takao Fukuoka, Ryohei Sasaki, Masaya Akashi

    Cetuximab, an epidermal growth factor receptor inhibitor (EI), is currently the only targeted molecular therapy used in combination with radiotherapy for head and neck squamous cell carcinoma (HNSCC). Gold nanoparticles (AuNPs) are expected to enhance radiotherapy effects in cancers. To investigate whether AuNPs combined with AG1478, an EI, enhanced irradiation effects on HNSCC cells, we first examined AG1478 adsorption on AuNP surfaces, using surface-enhanced Raman scattering, which indicated an adsorption equilibrium of AG1478 to AuNPs. We then used transmission electron microscopy to find internalization rates of AuNP alone and AuNP+AG1478; we found that intracellular uptake of AuNP alone and AuNP+AG1478 did not significantly differ. We compared cell numbers, proliferation, apoptosis, and migration between control cells and those treated with or without 60 nm AuNP (1.0 nM), AG1478 (0.5 μM), and irradiation (4 Gy). We found that AuNP+AG1478 inhibited proliferation more than AG1478 alone; the combination of irradiation+AuNP+AG1478 significantly reduced total cell numbers compared with the combination of irradiation+AuNP; AuNP+AG1478 increased apoptotic reaction to irradiation; the combinations of AuNP+AG1478 and irradiation+AuNP induced more apoptosis than AG1478+irradiation. Whereas AuNP+AG1478 enhanced cytotoxicity in human HNSCC cells by inhibiting proliferation, irradiation+AuNP enhanced cytotoxicity by inducing apoptosis.

    2020年, BioMed research international, 2020, 1281645 - 1281645, 英語, 国際誌

    研究論文(学術雑誌)

  • Satomi Arimoto, Takumi Hasegawa, Daisuke Takeda, Chizu Tateishi, Masaya Akashi, Shungo Furudoi, Takahide Komori

    OBJECTIVE: The present study investigated the effect of low-intensity pulsed ultrasound (LIPUS) on long-term osseous healing of the cleavage space between bone fragments after intraoral vertical ramus osteotomy (IVRO). STUDY DESIGN: Patients undergoing IVRO were randomly assigned to the LIPUS group (n = 12) or the control group (n = 9) after surgery. LIPUS treatments were applied daily to the cleavage space between bone fragments for 3 weeks. We observed 3-dimensional quantitative color mapping of the whole mandible created by computed tomography (CT) data at 1 month, 6 months, and 1 year postoperatively. On the basis of CT values, the color grades were classified as D1 to D5 by using the Misch criteria. We then calculated mean CT values and rated each color grade in different selection ranges. RESULTS: The mean CT values of the LIPUS group were significantly higher than those of the control group at 1 month, 6 months and 1 year postoperatively (P < .01). The color grades of the cleavage between bone fragments increased from D5 to D1 over time. CONCLUSIONS: Our results indicated that LIPUS promoted osseous healing after IVRO, thus improving bone density and offering clinical benefits.

    2019年12月, Oral surgery, oral medicine, oral pathology and oral radiology, 128 (6), 581 - 589, 英語, 国際誌

    研究論文(学術雑誌)

  • 西井 美佳, 五月女 さき子, 長谷川 巧実, 柚鳥 宏和, 川北 晃子, 兒島 由佳, 船原 まどか, 梅田 正博, 明石 昌也, 古森 孝英

    口腔・中咽頭がん放射線治療患者326例の口腔粘膜炎と口腔カンジダ症について後ろ向きに検討し、以下の結果を得た。1.グレード3口腔粘膜炎は、326例中131例(41.7%)に生じた。2.グレード3口腔粘膜炎の発症リスク因子として、男性、中咽頭原発、シスプラチンやセツキシマブ併用、白血球低値・リンパ球低値・ヘモグロビン低値、経口摂取が挙げられた。3.口腔カンジダ症は、326例中101例(31.0%)に生じた。4.口腔カンジダ症発症のリスク因子として、中咽頭原発、白血球減少、グレード2以上の口腔粘膜炎が挙げられた。ステロイド軟膏はリスク因子ではなかった。(著者抄録)

    (一社)日本口腔腫瘍学会, 2019年09月, 日本口腔腫瘍学会誌, 31 (3), 111 - 116, 日本語

    [査読有り]

  • 兒島 由佳, 河岡 有美, 川下 由美子, 山田 慎一, 栗田 浩, 長谷川 巧実, 古森 孝英, 明石 昌也, 上田 順宏, 桐田 忠昭, 高島 裕之, 渋谷 恭之, 梅田 正博

    2008年〜2017年に6施設で放射線治療を行った口腔・中咽頭がん患者366例において、放射線顎骨壊死(ORN)の発症リスク因子をCox比例ハザードモデルにて解析した。その結果、根尖病巣、重度歯周病、血清クレアチニン上昇がORN発症リスクを有意に増大させ、IMRT、照射前抜歯がリスクを有意に低下させた。照射後抜歯は有意ではなかったがリスクを増加させた。今後、ORNの発症予防法を確立する必要がある。(著者抄録)

    (一社)日本口腔腫瘍学会, 2019年09月, 日本口腔腫瘍学会誌, 31 (3), 117 - 120, 日本語

  • Yumi Muraki, Masaya Akashi, Yasuo Ejima, Takumi Hasegawa, Daisuke Miyawaki, Hirotaka Shinomiya, Mika Nishii, Naoki Otsuki, Ryohei Sasaki, Ken-Ichi Nibu, Takahide Komori

    BACKGROUND: The purpose of this study was to investigate the effectiveness of dental intervention before and after radiation therapy (RT) for head and neck malignancy on prevention of osteoradionecrosis (ORN) of the jaws. METHODS: This is a single-arm prospective study according to intervention protocol of prophylactic dental extraction before RT and routine follow-up after RT. The primary endpoint was the occurrence of jawbone exposure during the first 2 years after RT. RESULTS: Sixty-seven patients were assessed. Before RT, 144 teeth among 39 patients (58%) were prophylactically extracted. The occurrence of transient jawbone exposure during the first 2 years after RT was 7%. Because those jawbone exposures healed with intervention after RT, no jawbone exposure was found at 2 years after RT. CONCLUSIONS: Dental intervention both before and after RT seemed to be important to prevent ORN development. Further studies in larger cohorts are necessary.

    2019年09月, Oral and maxillofacial surgery, 23 (3), 297 - 305, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Akiko Sakakibara, Junya Kusumoto, Shunsuke Sakakibara, Takumi Hasegawa, Masaya Akashi, Tsutomu Minamikawa, Shungo Furudoi, Kazunobu Hashikawa, Takahide Komori

    BACKGROUND AND OBJECTIVE: Forearm free flaps are used after hemiglossectomy. However, no investigation has been performed on whether oral functions are better preserved when sizes of the resection and reconstruction flap are exact matches, or whether the size of the resection should be changed. We aimed to retrospectively examine whether size differences between the resection and reconstruction flap affect speech and swallowing functions postoperatively, and to determine whether there are more favorable flap size ratios. METHODS: This is a retrospective cohort study of patients undergoing hemiglossectomy using a forearm free flap between 2006 and 2016 at Kobe University Hospital, Japan. The effect of size difference between the resection and reconstruction flap on maintained oral function was assessed. Speech and swallowing functions were assessed, and their correlation with the ratio of the flap size to that of the resected area was determined. With these data, distribution maps of the relationship between the functional level and reconstructed dimension ratio were prepared. The more suitable reconstructed dimension ratio was examined and evaluated. The Fisher exact test, Kruskal-Wallis test, and Scheffe test were used in statistical analyses. RESULTS: Eighty-eight patients underwent hemiglossectomy using a forearm free flap during a 10-year period. Of these cases, 66 patients were included in this study, while 22 were excluded. The ratio of the area of the reconstruction flap to that of the resection site was 0.59-2.79 (median: 1.61). Sixty patients had flaps greater than the resection area, whereas 6 had smaller flaps. Significant differences were found in speech intelligibility and swallowing function when the reconstructed dimension ratio was categorized as follows: ≤1.3, 1.3-1.8, and ≥1.8. CONCLUSION: Our findings suggest that postoperative deterioration of oral functions after hemiglossectomy could be reduced if reconstruction is performed using a forearm free flap with a surface area 1.3 to 1.8 times greater than that of the resection area.

    2019年07月, Journal of plastic, reconstructive & aesthetic surgery : JPRAS, 72 (7), 1135 - 1141, 英語, 国際誌

    研究論文(学術雑誌)

  • Masaya Akashi, Kousuke Matsumoto, Daisuke Takeda, Junya Yamashita, Nanae Yatagai, Kazunobu Hashikawa, Takahide Komori

    Dental rehabilitation with osseointegrated implants in reconstructed mandibles is a common procedure, but the technique still requires improvement, especially in its reliability and technical simplification. We herein report dental rehabilitation of a free fibula-reconstructed mandible with scar contracture. A vestibuloplasty technique with application of a polyglycolic acid (PGA) sheet is described. The implants were inserted into a viable fibula flap with severe scar contracture of the overlying epithelium resulting from vascular instability in skin paddle. Only the fibula periosteum was sutured after implant insertion; exposed surfaces were covered with a combination of PGA sheet and fibrin sealant. The area with PGA sheet coverage gradually healed with moderate contracture. The epithelium around the almost implants became immobilized. The implant-supported removable partial denture with custom titanium bar was acceptable. Dental rehabilitation is possible for reconstructed mandibles with severe scar contracture. Application of a PGA sheet may be useful for vestibuloplasty in patients with reconstructed mandibles.

    2019年06月29日, Dentistry journal, 7 (3), 英語, 国際誌

    [査読有り]

  • Daisuke Takeda, Takumi Hasegawa, Izumi Saito, Satomi Arimoto, Masaya Akashi, Takahide Komori

    PURPOSE: Evaluation of the inner aspect of the maxillary sinus is important for the success of a sinus lift procedure. The most common surgical complication is perforation of the Schneiderian membrane, which is thought to occur because of the presence of maxillary sinus septa. Therefore, we retrospectively investigated the incidence and morphology of maxillary sinus septa using multiplanar reformatted computed tomographic (CT) images from dentate Japanese patients. METHODS: A total of 276 patients and 552 maxillary sinus segments were evaluated. The maxillary sinus septa were divided into four locations: forefront, anterior, middle, and posterior. The heights of the septa were measured at three sites from the deepest point of the sinus floor: lateral, mid-point, and medial. RESULTS: Sinus septa were identified in 191 of 552 (34.6%) maxillary sinus segments obtained from 111 of 276 (40.2%) patients. One unilateral septum was most commonly detected, and the sinus septa were most often located in the middle of the maxillary sinus. The average height of the identified septa was 8.69 ± 4.68 mm (mean ± standard deviation). CONCLUSION: Multiplanar reformatted CT images can identify maxillary sinus septa in any plane. The height of maxillary sinus septa in the dentate maxillae was higher than detected in previous studies. Appropriate treatment planning using CT images should be considered to prevent surgical complications.

    2019年06月, Oral and maxillofacial surgery, 23 (2), 233 - 237, 英語, 国際誌

    研究論文(学術雑誌)

  • Akiko Sakakibara, Junya Kusumoto, Shunsuke Sakakibara, Takumi Hasegawa, Masaya Akashi, Tsutomu Minamikawa, Shungo Furudoi, Kazunobu Hashikawa, Takahide Komori

    OBJECTIVE:  Musculocutaneous flap reconstruction surgery is one of the standard procedures following head and neck cancer resection. However, no previous studies have classified flaps in terms of muscle and fat or examined them after long-term follow-up. The purpose of this study was to estimate the fat and muscle volume changes in musculocutaneous flaps during long-term follow-up. METHODS:  We conducted a retrospective analysis of 35 patients after musculocutaneous flap reconstruction. The total, fat, and muscle volumes of the musculocutaneous flaps were measured using 3-dimensional images. Changes in flap volumes over time (1 month, 1 year [POY1], and 5 years [POY5] postoperatively) were assessed. Flap persistence was calculated using flap volumes at 1 month after reconstruction for reference. RESULTS:  Flap persistence at POY5 was 42.0% in total, 64.1% in fat, and 25.4% in muscle. Muscle persistence was significantly decreased (p < 0.0001). In a multiple regression analysis, decreased body mass index (BMI) of ≥ 5% influenced fat persistence less than muscle persistence at POY1; however, there was no significant difference at POY5. Postoperative radiation therapy was associated with a significant decrease in total flap persistence at POY1 (p = 0.046) and POY5 (p = 0.0097). Muscle persistence significantly decreased at POY5 (p = 0.0108). Age significantly influenced muscle volume at POY1 (p = 0.0072). CONCLUSION:  Reconstruction flaps are well-preserved with high fat-to-muscle ratios. Recommendations for weight maintenance are necessary for patients less than 2 years after surgery due to the influence of BMI on fat persistence. Radiation therapy is necessary for some patients based on their disease state. Intensity-modulated radiation therapy can be offered to reduce scattering irradiation to normal tissues.

    2019年05月, Journal of reconstructive microsurgery, 35 (4), 235 - 243, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Yumi Muraki, Takumi Hasegawa, Daisuke Takeda, Takeshi Ueha, Eiji Iwata, Izumi Saito, Rika Amano, Akiko Sakakibara, Masaya Akashi, Takahide Komori

    BACKGROUND/AIM: We recently investigated the contribution of the iPS-related genes SOX2, OCT4, and Nanog to de-differentiation by assaying for their mRNA levels. Given that mRNA expression does not always correlate with the protein levels, the aim of this study was to retrospectively determine the expression of these four iPS-related factors in human OSCC specimens by immunohistochemistry and examine their association with patient prognosis. MATERIALS AND METHODS: iPS cell-related gene expression in 89 OSCC patients by tissue microarray, and its correlation with clinicopathological factors, differentiation, metastasis, and poor prognoses were investigated. RESULTS: No evidence of statistically significant relationships was found between the expression of iPS cell-related genes and clinicopathological parameters. However, our data indicated that KLF4 expression was associated with survival, and poor tumor differentiation. In addition, high expression of KLF4 was an independent poor prognostic factor (p=0.004) for OSCC patients. CONCLUSION: In preoperative biopsies, higher KLF4 and poor differentiation may be clinically effective predictors for the prognosis of oral cancer.

    2019年03月, Anticancer research, 39 (3), 1205 - 1216, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Masaya Akashi, Nagisa Nanba, Junya Kusumoto, Takahide Komori

    In brief, perioperative oral intervention consists of elimination of odontogenic foci and maintenance of oral hygiene in patients undergoing surgery. The importance of oral intervention before, during, and after medical treatments is well-known, especially in cancer patients, because odontogenic foci such as untreated deep dental caries or periodontitis can cause systemic infection in patients with myelosuppression resulting from chemotherapy. Although perioperative oral intervention is currently recommended for patients with cardiovascular disease, its efficacy in this population has not been established. This article consists of three sections: first, we review the current knowledge about the association between dental disease and cardiovascular disease to show the importance of oral hygiene maintenance and the risks of invasive dental procedures in patients with cardiovascular disease; second, we introduce pertinent, but limited evidence concerning the effect of oral care in preventing postoperative pneumonia; and finally, we present the optimal strategy for perioperative oral intervention in cardiovascular surgery patients.

    2019年02月, General thoracic and cardiovascular surgery, 67 (2), 197 - 202, 英語, 国内誌

    [査読有り]

    研究論文(学術雑誌)

  • Masaya Akashi, Junya Kusumoto, Daisuke Takeda, Takashi Shigeta, Takumi Hasegawa, Takahide Komori

    PURPOSE: Few studies exist that focus on the details of perioperative antibiotic administration for surgery to treat medication-related osteonecrosis of the jaw (MRONJ). The regime and duration of perioperative antibiotics applied in published studies were reviewed to clarify appropriate perioperative antibiotic use in MRONJ surgery. METHODS: A literature search was conducted using the MEDLINE database via PubMed. RESULTS: The search resulted in 453 hits on PubMed. After reading the downloaded full-text articles, 17 articles met the inclusion and exclusion criteria. The most common perioperative antibiotic used for MRONJ surgery was a combination of penicillin-based antibiotics and β-lactamase inhibitor (52.9%), and the second most common regime was penicillin-based antibiotics with metronidazole (17.6%). The duration of administration was 2 weeks postoperatively in nine studies, whereas four studies applied long-term administration (2-6 weeks postoperatively). CONCLUSIONS: Oral and maxillofacial surgeons mostly prefer penicillin-based antibiotics plus β-lactamase inhibitor or metronidazole for MRONJ surgery. The duration of administration of these medications may be based on empirical experience.

    2018年12月, Oral and maxillofacial surgery, 22 (4), 369 - 378, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Satomi Arimoto, Takumi Hasegawa, Daisuke Takeda, Izumi Saito, Rika Amano, Masaya Akashi, Takahide Komori

    BACKGROUND/AIM: Tumor lymphangiogenesis plays a key role in lymph node (LN) metastasis in oral squamous cell carcinoma (OSCC). The purpose of this study was to investigate podoplanin and lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1) and their relationship to nodal metastasis and other clinicopathological variables. PATIENTS AND METHODS: Podoplanin and LYVE-1 expression of the primary tumor and normal tissue were investigated by means of a quantitative real-time PCR assay and immunohistochemistry in samples from 33 cases of OSCC. RESULTS: The mRNA high expression levels of both genes had a statistically significantly higher rate of LN metastasis (p<0.01) and histological grade (p<0.01 for podoplanin, p<0.05 for LYVE-1). High expression of each gene, as shown by immunohistochemistry, had a statistically significant higher rate of LN metastasis (p<0.01 for podoplanin, p<0.05 for LYVE-1). CONCLUSION: Podoplanin and LYVE-1 were strongly associated with LN metastasis.

    2018年11月, Anticancer research, 38 (11), 6157 - 6162, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Shun Teraoka, Yasumasa Kakei, Masaya Akashi, Eiji Iwata, Takumi Hasegawa, Daisuke Miyawaki, Ryohei Sasaki, Takahide Komori

    Enhancing the antitumor effect of radiation, while reducing damage to organs, is a significant challenge in radiation therapy for head and neck malignancies. One promising radiosensitizer is gold. The present study aimed to determine whether gold nanoparticles (AuNPs) have the potential to enhance the effects of X-ray irradiation on head and neck cancer cells. The human head and neck carcinoma cell line HSC-3 was used. Total cell number and the levels of cell proliferation and apoptosis were compared between control cells and cells treated with 5-nm AuNPs alone at four concentrations (0.1, 0.4, 1.0 and 10.0 nM), X-ray irradiation alone at three doses (2, 4 and 8 Gy), or a combination of 4 Gy X-ray irradiation and 1.0 nM AuNPs. Analysis of variance and Tukey-Kramer testing were performed to compare the different groups. The total number of cells significantly decreased following 4 and 8 Gy X-ray irradiation, compared with in the control group (control vs. 4Gy, P=2.19×10-4; control vs. 8Gy, P=1.28×10-6). The combination of 4 Gy X-ray irradiation and 1.0 nM AuNPs significantly reduced the total number of cells compared with 4 Gy X-ray irradiation alone (P=2.95×10-4). Cell proliferation was not affected by AuNP treatment alone, 4 Gy X-ray irradiation alone or the combination of X-ray irradiation and AuNPs. The combination of 4 Gy irradiation and 1.0 nM AuNPs significantly increased the number of apoptotic cells compared with 4 Gy irradiation alone (P=0.0261). In conclusion, AuNPs combined with X-ray irradiation enhanced the cytotoxic effect on human head and neck cancer cells in vitro, through the induction of apoptosis, but not inhibition of cell proliferation.

    2018年11月, Biomedical reports, 9 (5), 415 - 420, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Izumi Saito, Takumi Hasegawa, Takeshi Ueha, Daisuke Takeda, Eiji Iwata, Satomi Arimoto, Akiko Sakakibara, Masaya Akashi, Shunsuke Sakakibara, Yoshitada Sakai, Hiroto Terashi, Takahide Komori

    INTRODUCTION: Skin flap procedures are widely used to reconstruct skin and soft tissue defects. Skin flap necrosis is a serious postoperative complication. Many researchers have introduced pharmacological agents to improve flap ischemia in experimental studies. However, outcomes of these studies remain controversial. We previously demonstrated that transcutaneous CO2 application improves hypoxia in fracture repair. In this study, we hypothesized that improving hypoxia by transcutaneous CO2 application can improve the blood flow in skin flaps and increase angiogenesis. We investigated whether transcutaneous CO2 application can increase the survival of random-pattern skin flaps. MATERIALS AND METHODS: Six-week-old male Sprague-Dawley rats were divided into two equal groups: the control group (n = 6) and CO2 group (n = 6). A random-pattern skin flap was constructed in these rats. Topical CO2 was applied using a hydrogel every day for 5 days in the CO2 group. The flap survival area was measured on postoperative days 1, 3, and 5. The vessel density and expression of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), and hypoxia-inducible factor-1α (HIF-1α) were evaluated on postoperative day 5. RESULTS: A statistically significant difference was found in the percentage of the flap survival area between the two groups on postoperative days 3 and 5 (p < 0.05). Furthermore, the expression of VEGF and bFGF was significantly higher and that of HIF-1α was significantly lower in the CO2 than in the control group (p < 0.05). CONCLUSIONS: Transcutaneous CO2 application can improve the blood flow in skin flaps and increase angiogenesis, thus increasing the survival of random-pattern skin flaps.

    2018年11月, Journal of plastic, reconstructive & aesthetic surgery : JPRAS, 71 (11), 1644 - 1651, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Masaya Akashi, Megumi Kishimoto, Junya Kusumoto, Kimikazu Yakushijin, Hiroshi Matsuoka, Takahide Komori

    PURPOSE: The purpose of this study was to measure the frequency and identify factors associated with delayed socket healing after dental extraction in patients undergoing myelosuppressive chemotherapy for hematologic malignancy. MATERIALS AND METHODS: This prospective cohort study focused on delayed healing after extraction in patients with hematologic malignancy. Sockets with delayed healing were defined as those with intense pain and bone exposure 1 week postoperatively. Patients with and without delayed socket healing were compared using the Fisher exact test and Mann-Whitney U test with some variables. Receiver operating characteristics curve analysis was conducted to define cutoff values for delayed healing. RESULTS: One hundred ninety-four dental extractions in 93 patients (median age, 64 yr; range, 20 to 85 yr) were analyzed. The incidence of delayed socket healing was 7.5% (7 of 93 patients). There was no postoperative bleeding. Older age, type of hematologic malignancy (acute leukemia), shorter time from dental extraction to initiation of chemotherapy, low platelet count or hemoglobin level, requirement for red blood cell concentrate or platelet transfusion, and use of an absorbable hemostatic agent were statistically associated with the occurrence of delayed socket healing. Platelet and hemoglobin cutoffs were 4.6 × 104/μL and 7.7 g/dL, respectively. CONCLUSIONS: Although dental extraction can be safely performed in patients undergoing myelosuppressive chemotherapy for hematologic malignancy, oral surgeons should understand the potential risk for delayed socket healing. When considering dental extraction, patients with hematologic malignancy and low hemoglobin or platelet levels should be informed about the possibility of delayed socket healing.

    2018年10月, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 76 (10), 2057 - 2065, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Yujiro Hiraoka, Masaya Akashi, Satoshi Wanifuchi, Junya Kusumoto, Manabu Shigeoka, Takumi Hasegawa, Kazunobu Hashikawa, Hiroto Terashi, Takahide Komori

    OBJECTIVE: Pain is one of the most problematic symptoms in patients with osteoradionecrosis of the jaws. This study investigated the associations between pain severity and morphologic alterations of the mandibular canal and inferior alveolar nerve, in respective computerized tomography images and resected specimens of mandibular osteoradionecrosis. STUDY DESIGN: We assessed 14 lesions in 13 patients who underwent segmental mandibulectomy for surgical debridement and simultaneous reconstruction with free fibula flap (1 patient exhibited bilateral lesions). The extent of the mandibular canal bone defect on preoperative coronal computerized tomography images and the number of inferior alveolar nerve fascicles in resected specimens were evaluated. Comparisons were made between the slight pain and extreme pain groups. In most of the patients in the extreme pain group, either mandibular canal bone defects were absent or entire circumferential defects were present; inferior alveolar nerve fascicles were either distinguishable or completely absent in the resected specimens. RESULTS: Although there was no statistically significant association between extreme pain and computerized tomography or histopathologic findings, the histopathologically indistinguishable inferior alveolar nerve fascicles was significantly associated with slight pain. CONCLUSIONS: The degree of degeneration of mandibular canal and inferior alveolar nerve may be associated with pain severity in patients with mandibular osteoradionecrosis.

    Mosby Inc., 2018年09月, Oral surgery, oral medicine, oral pathology and oral radiology, 126 (3), 264 - 271, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Megumi Kishimoto, Masaya Akashi, Yasumasa Kakei, Junya Kusumoto, Akiko Sakakibara, Takumi Hasegawa, Shungo Furudoi, Ryohei Sasaki, Takahide Komori

    BACKGROUND: A problematic complication after radiation therapy is lymphedema. Development of lymphedema is associated with an increase in lymphatic paracellular permeability. The current study investigated the effects of radiation on intercellular junctions and paracellular permeability in cultured human dermal lymphatic endothelial cells (HDLECs). METHODS AND RESULTS: Double immunofluorescence staining with vascular endothelial (VE)-cadherin and actin immediately after X-ray irradiation (5 or 20 Gy) was performed. Morphological changes induced by irradiation were assessed. Cell viability and paracellular permeability after irradiation were also evaluated. Broad junctions in which VE-cadherin was accumulated at cell-cell contacts and almost colocalized with actin were significantly decreased in a dose-dependent manner in confluent and sparse irradiated HDLECs. Irradiation shortened the width of VE-cadherin-positive areas at the cell-cell contacts. Actin filaments did not colocalize with VE-cadherin after 20 Gy irradiation. Although cell viability was not affected by irradiation, paracellular permeability significantly increased in a dose-dependent manner. CONCLUSIONS: A dose of 5 or 20 Gy irradiation in HDLECs does not affect cell viability, but changes VE-cadherin mediated intercellular junctions and actin structure, resulting in an increase of paracellular permeability. Further investigations on the regulatory proteins involved in radiation-induced changes, which were observed in the current study, may contribute to development of lymphedema therapy.

    2018年08月, Lymphatic research and biology, 16 (4), 390 - 396, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • T. Hasegawa, S. I. Yamada, N. Ueda, S. Soutome, M. Funahara, M. Akashi, S. Furuno, H. Miyamoto, S. Hayashida, R. Amano, K. Mori, Y. Kojima, H. Kurita, T. Kirita, M. Umeda, Y. Shibuya, S. Fujita, T. Komori, Japanese Study Group of Cooperative Dentistry with Medicine (JCDM)

    Little research has been conducted into hypoesthesia, and no studies have elucidated the risk factors for refractory hypoesthesia and compared treatment modalities. The purpose of this multicentre retrospective cohort study was to investigate the relationships between various risk factors, treatment modalities, and refractory hypoesthesia. Risk factors for refractory hypoesthesia after oral surgery were evaluated using univariate and multivariate analysis. To minimize the selection bias associated with a retrospective data analysis, a propensity score analysis was performed between the medication and non-medication groups (65 sites in each group). Moderate or severe hypoesthesia (odds ratio 13.42) and no or late administration of ATP/vitamin B12 (odds ratio 2.28) were significantly associated with refractory hypoesthesia. In the propensity score analysis, the incidence rate of refractory hypoesthesia in the medication group was lower than that in the non-medication group (P < 0.001). This study demonstrated the multivariate relationships between various risk factors, treatment modalities, and refractory hypoesthesia. Moderate or severe hypoesthesia and no or late administration of ATP/vitamin B12 were significantly associated with refractory hypoesthesia. Therefore, clinicians should consider these risk factors and initiate early oral administration of ATP/vitamin B12 in cases of hypoesthesia.

    Churchill Livingstone, 2018年06月01日, International Journal of Oral and Maxillofacial Surgery, 47 (6), 794 - 801, 英語

    [査読有り]

    研究論文(学術雑誌)

  • 血管柄付遊離皮弁を用いた口腔癌の術後感染に関わる因子の検討

    梶 真人, 古土井 春吾, 岸本 恵美, 岩田 英治, 高橋 淳子, 楠元 順哉, 明石 昌也, 古森 孝英

    ガイドライン導入前の当院の抗菌薬予防投与指針に準じて抗菌薬予防投与を行った口腔癌即時再建手術の術後感染発症例を後ろ向きに調査し、術後感染の発症に影響を与える因子について検討した。当科で気管切開術、口腔癌切除術、頸部郭清術および血管柄付遊離皮弁による即時再建術を施行した40例を対象とした。術後感染を認めた症例は40例中12例で、発症率は30.0%であった。基礎疾患の有無による術後感染発症率に有意差は認められず、アルブミン値およびヘモグロビン値との関連もなかった。手術時間での比較では、術後感染を認めなかった症例の平均手術時間が684.1分であったのに対し、術後感染発症例の平均手術時間は785.0分と長く有意差を認めた。また、術中の出血量においても感染を認めなかった症例の平均出血量が671.9mlであったのに対し、術後感染発症例の平均は1050.3mlと多く有意差を認めた。

    (一社)日本口腔感染症学会, 2018年06月, 日本口腔感染症学会雑誌, 25 (1), 14 - 19, 日本語

    [査読有り]

  • Michinori Maeda, Marina Hirose, Keinoshin Wada, Megumi Kishimoto, Masaya Akashi, Akira Kimoto, Takahide Komori, Yasuyuki Shibuya

    The aim of this study was to clarify the masticatory function and oral health-related quality of life (OHRQoL) for different ranges of mandibulectomy and also continuity resection of the mandible. A total of thirty one patients who underwent mandibulectomy and were classified into AT, body, and marginal resection (MR) groups according to the CAT classification were investigated. The masticatory function was evaluated using a color-changing gum, a gummy jelly, and a modified Sato's questionnaire. The OHRQoL was evaluated using the Oral Health Impact Profile (OHIP), which included seven subscales. There were significant differences between the AT group and body group in the findings from the color-changing gum and the OHIP (P < 0.05). There was also a significant difference between the AT group and body group regarding the degree of physical disability and psychological disability (subscales of the OHIP) (P < 0.05). There were no significant differences between the body and MR group in any of the tests. Consequently, the body group showed a higher masticatory function and OHRQoL than the AT group despite having the same category of mandibulectomy defect however, the masticatory function and OHRQoL in the body and MR groups were found to be closely similar, at least, regarding the chewing performance.

    Elsevier Ltd, 2018年05月01日, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, 30 (3), 220 - 224, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Masaya Akashi, Shun Teraoka, Yasumasa Kakei, Junya Kusumoto, Takumi Hasegawa, Tsutomu Minamikawa, Kazunobu Hashikawa, Takahide Komori

    BACKGROUND: This study aimed to evaluate posttreatment soft-tissue changes in patients with oral cancer with computed tomography (CT). To accomplish that purpose, a scoring system was established, referring to the criteria of lower leg lymphedema (LE). METHODS AND RESULTS: One hundred and six necks in 95 patients who underwent oral oncologic surgery with neck dissection (ND) were analyzed retrospectively using routine follow-up CT images. A two-point scoring system to evaluate soft-tissue changes (so-called "LE score") was established as follows: Necks with a "honeycombing" appearance were assigned 1 point. Necks with "taller than wide" fat lobules were assigned 1 point. Necks with neither appearance were assigned 0 points. Comparisons between patients with LE score ≥1 and LE score = 0 at 6 months postoperatively were performed using the Fisher exact test for discrete variables and the Mann-Whitney U test for continuous variables. Univariate predictors associated with posttreatment changes (i.e., LE score ≥1 at 6 months postoperatively) were entered into a multivariate logistic regression analysis. Values of p < 0.05 were considered to indicate statistical significance. The occurrence of the posttreatment soft-tissue changes was 32%. Multivariate logistic regression analysis showed that postoperative radiation therapy (RT) and bilateral ND were potential risk factors of posttreatment soft-tissue changes on CT images. CONCLUSIONS: Sequential evaluation of "honeycombing" and the "taller than wide" appearances on routine follow-up CT revealed the persistence of posttreatment soft-tissue changes in patients who underwent oral cancer treatment, and those potential risk factors were postoperative RT and bilateral ND.

    2018年04月, Lymphatic research and biology, 16 (2), 147 - 153, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • 榎本 由依, 明石 昌也, 平岡 佑二郎, 重岡 学, 南川 勉, 古森 孝英

    症例は65歳男性で、神経線維腫症の診断で顎口腔領域に放射線療法が施行された。口腔内全体に広がる小腫瘤の精査のため生検を施行し、神経線維腫の診断となった。右側下顎の腫脹・疼痛を認め、パノラマX線写真で放射線性顎骨壊死を疑った。右側下顎臼歯部の近辺に乳頭腫様腫瘤を伴う、易出血性の30mm程度の潰瘍を認め、潰瘍周囲には硬結を触れた。頬粘膜・舌・口蓋粘膜全域に及ぶ多発性の乳頭腫様腫瘤を認めた。パノラマX線写真、CT画像では、右側下顎臼歯部から下顎枝にかけての舌側皮質骨から骨髄質に至る不規則な骨吸収像を認めた。臨床経過や画像所見から右側下顎骨髄炎を疑ったが、悪性腫瘍の可能性もあった。口腔内潰瘍部と潰瘍周囲の腫瘤から生検を施行し、扁平上皮癌と診断した。Cowden症候群の可能性が示唆されたため、下部消化管内視鏡検査とFDG・PETを施行し、下顎歯肉癌を合併したCowden症候群と診断した。下顎歯肉癌に対して全身麻酔下に、気管切開・右側頸部郭清術・下顎半側切除術・右側遊離腹直筋皮弁による即時再建術を施行した。局所および頸部再発等なく経過良好である。

    (公社)日本口腔外科学会, 2018年04月, 日本口腔外科学会雑誌, 64 (4), 213 - 218, 日本語

    [査読有り]

  • Masaya Akashi, Satoshi Wanifuchi, Eiji Iwata, Daisuke Takeda, Junya Kusumoto, Shungo Furudoi, Takahide Komori

    PURPOSE: The appearance of osteoradionecrosis (ORN) and medication-related osteonecrosis of the jaw (MRONJ) is similar, but clinically important differences between ORN and MRONJ exist. The aim of this study was to compare the clinical data between ORN and MRONJ and to reveal the critical differences between these diseases. METHODS: We retrospectively reviewed the epidemiological data, clinical findings, and treatment in 27 ORN and 61 MRONJ patients. Radiographic signs before the initiation of treatment were also assessed. RESULTS: The median age (P = 0.0474) and the ratio of female to male patients (P < 0.0001) were significantly higher in MRONJ patients. There were significantly more MRONJ patients who reported a history of pain when compared with ORN patients (P = 0.0263). As an aetiological factor, tooth extraction was significantly more relevant to MRONJ than ORN (P = 0.0352). When assessing the radiographic signs on computed tomographic images, periosteal reaction was found only in MRONJ patients (P = 0.0158). Minimal debridement was performed significantly more frequently for MRONJ (P = 0.0093), and by contrast, surgical resection was performed more frequently for ORN (P = 0.0002). CONCLUSIONS: Understanding the clinical and underlying pathological differences between ORN and MRONJ probably contributes to the selection of appropriate treatment for each patient.

    2018年03月, Oral and maxillofacial surgery, 22 (1), 59 - 63, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • 岩田 英治, 古土井 春吾, 鰐渕 聡, 岸本 恵実, 明石 昌也, 古森 孝英

    症例は72歳男性で、左腎癌に対して左腎摘出術を施行した。経過観察していたが、胸部CT画像にて肺癌を指摘された。左肺癌の診断で胸腔鏡補助下左下葉切除術を施行し、病理組織学的に腎細胞癌の肺転移と診断した。経過観察していたが、胸部CT画像で右胸膜・縦隔リンパ節転移を認めた。スニチニブの経口投与を開始したが、6日後に肝機能障害を認めたため中止した。スニチニブを減量し、2週内服1週休薬で施行し、4コース目までが終了した。右下顎大臼歯部の骨露出および同部への舌の接触痛を自覚した。薬剤関連性顎骨壊死と診断し、口腔衛生管理および局所の洗浄を行うこととした。露出骨に対し鋭縁研磨を行い、右舌縁部の潰瘍に対しデキサメタゾン軟膏塗布を行った。スニチニブは減量し、2週内服1週休薬で継続した。2ヵ月後には骨露出部に歯肉の増生を認め、露出範囲は縮小し、右舌縁部の潰瘍は消失した。初診より8ヵ月目の胸部CT画像から肺転移巣にPDが確認され、スニチニブを中止し、新たにアキシチニブの内服を開始した。胸部CT画像から胸膜転移巣の増大ありと判断した。アキシチニブを中止し、新たにオプジーボの内服を開始し、現在も継続中である。

    (公社)日本口腔外科学会, 2018年02月, 日本口腔外科学会雑誌, 64 (2), 83 - 87, 日本語

    [査読有り]

  • Masaya Akashi, Takumi Hasegawa, Satoru Takahashi, Takahide Komori

    Temporomandibular joint (TMJ) osteoarthritis (OA) is a disease of the bone, cartilage, and supporting tissues of the joint. Patients with advanced TMJ-OA often have symptoms such as pain, swelling, and joint dysfunction, and they sometimes require surgical intervention when conservative treatment is not effective. The etiology of TMJ-OA remains elusive. The usefulness of 4-dimensional (4D) computed tomography (CT) in motion analysis of various joints has recently been reported. This article introduces a novel imaging technique of 4D CT that aims to identify kinematic features that may be associated with the etiology of TMJ-OA. In a 69-year-old female patient with severe TMJ-OA, 4D CT evaluation of condylar movement was performed. During the scan, she was instructed to masticate a cookie normally and her natural condylar movement during mastication was evaluated. The coronal 4D CT motion images showed that the synovial cavity was narrower on the affected side than on the unaffected side. Repeated friction between the articular surface of the condyle and the caudal surface of the articular eminence was observed during natural mastication. Although friction between the condyle and articular eminence has been considered a factor in the initiation and progression of TMJ-OA in previous experimental studies using animals, this is the first study to directly visualize the friction between the atrophic and flattened condylar surface and the articular eminence. Four-dimensional CT is a novel imaging technique with the potential to assess kinematic features that cannot be visualized with other imaging modalities in patients with TMJ disease.

    W.B. Saunders, 2018年02月, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 76 (2), 304 - 313, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Masaya Akashi, Satoshi Wanifuchi, Junya Kusumoto, Megumi Kishimoto, Yasumasa Kakei, Kazunobu Hashikawa, Takahide Komori

    It was hypothesized that fluorodeoxyglucose (FDG) uptake on post-treatment follow-up positron emission tomography with computed tomography (PET CT; using PET CT to monitor and rule out recurrence and metastasis of head and neck carcinoma) would be useful for detecting and understanding the disease state of osteoradionecrosis (ORN) of the jaw. The present study included 14 patients who developed mandibular ORN following radiation therapy (RT) for head and neck cancer and underwent follow-up PET CT several times following RT. Areas exhibiting FDG uptake were retrospectively assessed on post-treatment follow-up PET CT images and were classified into three types: Spot type: Only spot accumulation of FDG; localized type: Accumulation of FDG restricted to within the bone resorption area; extensive type: Accumulation of FDG extending into surrounding soft tissue. PET classification at the time of clinical diagnosis of mandibular ORN in the 14 patients demonstrated the extensive type in 43%, localized type in 36% and spot type in 21%. An increased area of FDG uptake around the ORN was revealed retrospectively on post-treatment follow-up FDG PET-CT images in 50% of patients. Alterations in PET classification included spot type to localized type in 36% and localized type to extensive type in 14%. A significantly increased number of patients with extensive-type ORN (P=0.026) required surgery. Post-treatment follow-up FDG-PET CT may be useful for early detection and better understanding of ORN.

    2018年01月, Molecular and clinical oncology, 8 (1), 61 - 67, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Yumi Ohtsuki, Masaya Akashi, Kazunobu Hashikawa, Takahide Komori

    Oroantral fistulas (OAF), which develop as a result of maxillary sinus infection caused by oroantral communication, are sometimes intractable. We present a case of closure with a facial artery musculomucosal flap (FAMM flap) for intractable OAF. A 73-year-old man presenting with an OAF and rhinorrhea was referred to our department. Twenty-eight years earlier, he had undergone bilateral radical surgery for maxillary sinusitis, and six years earlier, he underwent extraction of his right maxillary first and second molars. Six months after the dental extractions, he developed maxillary sinusitis secondary to oroantral communication. Four years after the dental extractions, he underwent endoscopic sinus surgery with closure of the OAF with a rotational pedicled palatal flap, but the OAF recurred. To treat the OAF recurrence, we used a FAMM flap. His postoperative course was good, with no OAF recurrence 6 years after surgery. FAMM flaps are useful to close intractable OAFs.

    Elsevier Ltd, 2018年, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, 英語

    [査読有り]

    研究論文(学術雑誌)

  • A Case Series of Fibro-Osseous Lesions of the Jaws.

    Masaya Akashi, Kenji Matsuo, Manabu Shigeoka, Yasumasa Kakei, Takumi Hasegawa, Akira Tachibana, Shungo Furudoi, Takahide Komori

    The aim of this case series was to reveal the difficulties in diagnosing fibro-osseous lesions with radiological and histopathological examinations and quantify the potential risk of infection to fibro-osseous legions. To analyze the concordance between radiological and histopathological diagnoses, this retrospective case series included patients who were clinically diagnosed with fibro-osseous lesions via radiological findings and excluded the patients who did not undergo histopathological examinations. This study also included the patients in whom histopathological results confirmed fibro-osseous legions when preoperative radiological diagnosis did not include fibro-osseous legions. Eleven patients (three men, eight women; median age 24.5 years, range 15-57 years) were enrolled. Although radiological diagnoses of fibrous dysplasia (FD) corresponded with histopathological diagnoses in seven patients, mismatches between radiological findings and histopathological results were found in three patients. In one patient, suspected diagnosis with radiological examinations was malignant lymphoma or FD. In two patients, the histopathological differentiation between FD and ossifying fibroma (OF) was difficult. One patient had lesion recurrence which was suspected to be OF with surgical findings and postoperative course after the initial surgery. In three patients, infections of FD were found. Preoperative diagnosis of OF with radiographic feature of unilocular radiolucency is difficult. In cases in which histopathological differentiation between FD and OF is difficult, operative findings should be used because OF is often found to be well-encapsulated and easily enucleated. Bone in FD showing mixed radiolucent-radiopaque may be vulnerable to infection.

    2017年12月18日, The Kobe journal of medical sciences, 63 (3), E73-E79 - 79, 英語, 国内誌

    [査読有り]

    研究論文(学術雑誌)

  • Yasumasa Kakei, Masaya Akashi, Masahiko Kashin, Sayaka Komori, Takahide Komori

    © 2017 Asian AOMS, ASOMP, JSOP, JSOMS, JSOM, and JAMI Objective Dental injury is the most common complication of general anaesthesia. The primary purpose of this study was to report the occurrence, location, type, and treatment of dental injury caused by endotracheal intubation. Methods This retrospective study evaluated 36,627 cases of general anaesthesia at our hospital from January 2008 through December 2015. The examination items included risk factors such as age; sex; surgical department; type of intubation(orotracheal or nasotracheal intubation); presence of preoperative trismus; Cormack–Lehane classification; experience of the attending anaesthesiologist; intubation appliance; mouth guard use; tooth mobility diagnosed by attending anaesthesiologist before surgery; the location, type, and treatment of injured teeth; and forensic implications. Results The incidence of dental injury was 0.06% (22 of 36,627 patients). There was a significant difference in the rate of dental injury according to age (0.026% among those <60 years of age vs. 0.096% among those ≥60 years; P < 0.05) and according to surgical department (0.189% among neurosurgery patients; P < 0.05). The most comm

    Elsevier Ltd, 2017年11月01日, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, 29 (6), 518 - 521, 英語

    研究論文(学術雑誌)

  • Masaya Akashi, Toshinori Sekitani, Yumi Ohtsuki, Yasumasa Kakei, Junya Kusumoto, Takumi Hasegawa, Michinori Maeda, Noriyuki Negi, Kazunobu Hashikawa, Yasuyuki Shibuya, Satoru Takahashi, Takahide Komori

    OBJECTIVE: Few studies evaluate condylar movement following mandibular reconstruction. The main objective of this study was to show that axial four-dimensional computed tomography (4DCT) could visualize bilateral protrusive condylar movement directly. We used axial 4DCT images to assess condylar protrusion in patients who underwent mandibular reconstruction. METHODS: We enrolled seven healthy volunteers (median age 30 years, range 27-38 years) and seven patients (median age 65 years, range 52-80 years), who underwent mandibulectomy (segmental in five, hemi in one, marginal in one) and free flap reconstruction (using the fibula in six and the radial forearm in one). Six study subjects were instructed to masticate a cookie during the 4DCT scan (the seventh made chewing motions). The distance between the most anterior and posterior positions of the bilateral condyles on 4DCT (axial view) images was then measured and compared between controls and patients using the Mann-Whitney U-test. RESULTS: The crosswise difference in the distances of condylar protrusion was significantly greater in patients than in the controls. CONCLUSION: Axial 4DCT images can visualize a bilateral condylar protrusive path. Axial 4DCT images for patients who have undergone mandibulectomy and reconstruction may be useful for evaluation of functional movement of condyles.

    CHURCHILL LIVINGSTONE, 2017年11月, Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery, 45 (11), 1778 - 1783, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Masaya Akashi, Junya Kusumoto, Akiko Sakakibara, Kazunobu Hashikawa, Shungo Furudoi, Takahide Komori

    BACKGROUND: The lack of uniformity of criteria for defining recipient-site infection after oral oncologic surgery with simultaneous reconstruction is problematic despite numerous studies on this issue. This study aimed to investigate the difference in the criteria for defining recipient-site infection after oral oncologic surgery with reconstruction. METHODS: A Medline search was performed via PUBMED using the following combinations of key terms that were tagged in the title, abstract, or both: "surgical site infection-head neck," "surgical site infection-oral cancer," "antibiotic prophylaxis-head neck," and "surgical site infection-oral carcinoma." Search results were filtered between 2005 and 2017. Articles in which there was no mention of the criteria for definition of surgical-site infection were excluded. RESULTS: The number of articles that met the inclusion criteria was 24. The lack of uniformity in the criteria for defining recipient-site infection in each article appeared to be attributable mainly to differences in whether an orocutaneous fistula and superficial incisional infection were regarded as recipient-site infection. CONCLUSION: Reconsideration of the categorization of orocutaneous fistula as infection, regardless of the etiology, and differentiation of superficial and deep incisional infections are necessary for correct assessment of recipient-site infection in oral oncologic surgery.

    MARY ANN LIEBERT, INC, 2017年10月, Surgical infections, 18 (7), 755 - 764, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Tetsuya Hara, Tomoko Monguchi, Noriko Iwamoto, Masaya Akashi, Kenta Mori, Toshihiko Oshita, Mitsumasa Okano, Ryuji Toh, Yasuhiro Irino, Masakazu Shinohara, Yui Yamashita, Go Shioi, Mikio Furuse, Tatsuro Ishida, Ken-Ichi Hirata

    OBJECTIVE: Recent genome-wide association studies newly identified the human KIAA1462 gene as a new locus for coronary artery disease. However, the function of the gene product, named JCAD (junctional protein associated with coronary artery disease), is unknown. Because JCAD is expressed at cell-cell junctions in endothelial cells, we hypothesized and tested whether JCAD regulates angiogenic processes in vitro and in vivo. APPROACH AND RESULTS: Cell culture experiments revealed impaired angiogenic ability (proliferation, migration, and cord formation) by the knockdown of JCAD with siRNA (P<0.05 versus control siRNA). We have generated mice lacking JCAD (mKIAA1462-/-) by gene-targeted deletion of JCAD to address in vivo angiogenic function. mKIAA1462-/- mice did not show morphological differences in development of retinal vasculature. Ex vivo aortic ring model demonstrated impaired neovascularization in aorta from mKIAA1462-/- mice than control wild-type mice (P<0.05). Tumor growth was assessed by monitoring tumor volume after the subcutaneous injection of melanoma, LLC (Lewis lung carcinoma), and E0771 cells into the mice. mKIAA1462-/- mice exhibited significantly smaller tumor volume compared with wild-type mice (P<0.001). Histological assessment of the tumor exhibited less smooth muscle actin-positive neovascularization determined by CD31-positive vascular structure in tumor of mKIAA1462-/- mice than wild-type mice, indicating that knockdown of JCAD inhibited the vascular maturation in pathological angiogenic process. CONCLUSIONS: These in vitro and in vivo studies suggest that JCAD has a redundant functional role in physiological angiogenesis but serves a pivotal role in pathological angiogenic process after birth.

    LIPPINCOTT WILLIAMS & WILKINS, 2017年09月, Arteriosclerosis, thrombosis, and vascular biology, 37 (9), 1667 - 1673, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • 明石 昌也, 鰐渕 聡, 岩田 英治, 筧 康正, 長谷川 巧実, 鈴木 泰明, 古森 孝英

    頭頸部癌に対する放射線治療は重要な治療法であるが、重篤な合併症の一つに放射線性顎骨壊死がある。最も良く知られた発症の誘因は、抜歯などの外科的侵襲である。今回、われわれはインプラント周囲に放射線性顎骨壊死を生じ、長期に渡る保存的治療ののちに腐骨分離した1例を経験したので報告する。症例は68歳の女性。左側顎下腺腺様嚢胞癌の診断のもと、手術と術後化学放射線療法が施行された。放射線治療から3年後、右側下顎に放射線治療前より埋入されていたインプラント周囲溝からの排膿を伴う感染所見を認め、当科を受診した。インプラント周囲の放射線性顎骨壊死の診断のもと、局所の洗浄や抗菌薬経口投与などの保存的治療を継続し、放射線治療から5年後インプラントと腐骨が一塊に分離したため、局所麻酔下に除去した。放射線性顎骨壊死は多くの場合難治性であり、治療法は随伴症状の重篤度や全身状態などを総合的に判断し選択する必要がある。予防にはインプラント周囲の衛生状態の維持を目的とした放射線治療後の口腔衛生管理がきわめて重要である。(著者抄録)

    (公社)日本顎顔面インプラント学会, 2017年08月, Japanese Journal of Maxillo Facial Implants, 16 (2), 75 - 80, 日本語

    [査読有り]

  • Yasumasa Kakei, Shun Teraoka, Masaya Akashi, Takumi Hasegawa, Takahide Komori

    The benefits of epidermal growth factor receptor (EGFR) targeting in the treatment of head and neck cancer, have been documented. However, a minority of patients with head and neck cancer are unresponsive to EGFR targeting therapies. The present study evaluated the effects and limitations of an EGFR inhibitor on oral squamous cell carcinoma cells, particularly on cell-cell junctions mediated by epithelial (E)-cadherin. HSC-3 oral squamous cell carcinoma cells were treated with the EGFR inhibitor, AG1478 (0, 0.5, 2, 10 and 50 µM), and the effects of EGFR inhibition in HSC-3 cells were evaluated by wound healing assays, E-cadherin immunostaining and measurement of transepithelial electrical resistance in vitro. It was observed that treatment of oral squamous cell carcinoma cells with AG1478 suppressed cell motility, altered cell morphology and increased the number of cell-cell junctions compared with untreated control cells. Knockdown of EGFR induced a similar phenotype to that observed by the inhibition of EGFR. Furthermore, in oral squamous cell carcinoma cells treated with high-dose EGFR inhibitor (50 µM), the small number of cells that survived formed cell-cell junctions that were positive for E-cadherin expression. In cells treated with low concentrations of EGFR inhibitor (2 µM), recovery of epithelial properties was observed. The retention of E-cadherin expression in cells that survived high-dose EGFR inhibitor treatment may be a survival mechanism of cancer cells.

    SPANDIDOS PUBL LTD, 2017年08月, Experimental and therapeutic medicine, 14 (2), 953 - 960, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • 頭頸部癌患者における化学放射線療法による口腔粘膜炎の重症度を予測する因子

    岸本 恵実, 古土井 春吾, 岩田 英治, 藤林 淳子, 楠元 順哉, 明石 昌也, 古森 孝英

    術後追加療法として化学放射線療法(CRT)を行った口腔癌21例、中咽頭癌26例の計47例(男33例、女14例、平均年齢59.9歳、範囲16〜76歳)を対象に、頭頸部癌に対するCRT中の口腔粘膜炎の重症度を予測する因子について、後ろ向きに検討した。CRT中に出現した口腔粘膜炎のGrade別はGrade 2が40例(85.1%)、Grade 3が7例(14.9%)であり、背景因子の比較では栄養学的予後指数(PNI)に有意な群間差を認めた。また、Grade 3出現例ではGrade 2出現例よりも末梢血総リンパ球数、血清アルブミン濃度が有意に低値を示し、算出したCRT開始前のPNIについてROC曲線のカットオフ値は41.1で、AUC:0.86、感度:0.95、特異度:0.71であった。PNIは口腔粘膜炎の重症度を予測する因子となる可能性が示唆された。

    (一社)日本口腔感染症学会, 2017年07月, 日本口腔感染症学会雑誌, 24 (1), 9 - 13, 日本語

    [査読有り]

  • Izumi Saito, Takumi Hasegawa, Eiji Iwata, Natsuki Yonezawa, Satomi Arimoto, Daisuke Takeda, Akiko Sakakibara, Masaya Akashi, Tsutomu Minamikawa, Takahide Komori

    Objective Previous reports regarding postoperative drainage have documented complications associated with the drainage volume (DV). However, there is little information available concerning the postoperative and operative factors that influence postoperative DV. In this study, we retrospectively investigated the relationship between postoperative drainage and various risk factors in patients undergoing head and neck surgery for oral cancer. Methods This study included 136 patients (88 males, 48 females, mean age 67.2 ± 12.9 years) who underwent head and neck surgery for oral cancer. We retrospectively investigated the following variables: age, sex, subsite, medical history, surgical procedure, operative time, blood loss, duration of drain retention, DV, and postoperative complications. Results DV after reconstruction with a pectoral major musculocutaneous flap was significantly higher than DV after reconstruction with a forearm flap (p <  0.05). DV was significantly greater in cases involving a large amount of blood loss or a long operative time (p <  0.05). DV was significantly greater after modified radical neck dissection than after supraomohyoid or submandibular neck dissection (p <  0.05). DV was significantly greater in patients receiving antithrombotic therapy than in patients without (p <  0.05). Multiple regression analysis revealed that total DV was positively correlated with older age, antithrombotic therapy, type of surgery (advanced surgery), and type of neck dissection (wide range). Conclusions DV was greater in those with older age, antithrombotic therapy, advanced surgery, and wide-ranging neck dissection. Therefore, clinicians should consider these risk factors and pay special attention to the postoperative management of drains in such cases.

    Elsevier Ltd, 2017年05月01日, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, 29 (3), 217 - 221, 英語

    [査読有り]

    研究論文(学術雑誌)

  • 肺癌術後肺合併症と周術期口腔機能管理の有用性

    岩田 英治, 長谷川 巧実, 西井 美佳, 明石 昌也, 古森 孝英

    (一社)日本口腔ケア学会, 2017年04月, 日本口腔ケア学会雑誌, 11 (3), 170 - 170, 日本語

    [査読有り]

  • Masaya Akashi, Kazuhiro Tanaka, Junya Kusumoto, Shungo Furudoi, Kohkichi Hosoda, Takahide Komori

    INTRODUCTION: Odontogenic foci can rarely cause intracranial infection. Hematogenous spread is considered to be the most important pathophysiological mechanism of intracranial infection of odontogenic origin. To investigate the oral origin of intracranial infections, oral surgeons should understand the underlying mechanisms by which oral bacteria spread to the central nervous system. However, there have been very few reports of intracranial infection resulting from odontogenic infection. CASE REPORTS: The authors report the cases of a 64-year-old man, a 68-year-old man, and a 64-year-old woman whose brain abscesses perhaps have arisen from odontogenic foci, because other sources of intracranial infection such as endocarditis and maxillary sinusitis were not found. Bacteriological examination of brain abscess specimens identified Staphylococcus aureus in case 1, Streptococcus constellatus, Fusobacterium nucleatum, and Parvimonas micra in case 2, and Lactobacillus catenaformis, Porphyromonas gingivalis, and F. nucleatum in case 3. All suspected causal teeth had no obvious signs of acute inflammation in all three cases. CONCLUSIONS: Oral surgeons should understand these characteristics of odontogenic brain abscess, in which the potentially causal odontogenic foci often lack acute symptoms. If other origins of infection are not found, it would be better to eliminate the potentially causal odontogenic foci for improvement of oral hygiene, however, the decision making criteria to eliminate suspected causal teeth is needed to be elucidated.

    2017年03月, Journal of maxillofacial and oral surgery, 16 (1), 58 - 64, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Meaning and Limitation of Cortical Bone Width Measurement with DentaScan in Medication-Related Osteonecrosis of the Jaws.

    Eiji Iwata, Masaya Akashi, Megumi Kishimoto, Junya Kusumoto, Takumi Hasegawa, Shungo Furudoi, Takahide Komori

    Mandibular cortical bone measurement with x-ray imaging is known to be a potentially useful tool in the detection of dimensional changes caused by bisphosphonate. The primary purpose of this study was to assess the meaning and limitation of cortical bone measurement with computed tomography (CT) in patients with medication-related osteonecrosis of the jaw (MRONJ). The investigators obtained DentaScan images of the mandible from 15 patients with MRONJ, 15 patients with a history of antiresorptive agent administration without symptoms of MRONJ (non-MRONJ), and 15 control subjects. The cortical bone width measured on DentaScan images was compared between the three groups (ANOVA and Tukey's test). Interobserver reliability between two observers was also assessed. The values of interclass correlation coefficient were 0.48 in the MRONJ group, 0.29 in the Non-MRONJ group, and 0.34 in control group. The cortical bone widths calculated both by observer 1 and observer 2 were thicker in patients with MRONJ than in the non-MRONJ group and controls. There were significant differences in cortical bone width among the MRONJ, non-MRONJ, and control groups in observer 1 (P < 0.001) and observer 2 (P < 0.001), specifically comparing the MRONJ group with the non-MRONJ group and the control group. Cortical bone width measurement is useful for the distinction between medication-related osteonecrosis of the jaw and normal bone, in spite of the low interobserver reliability.

    Kobe University School of Medicine, 2017年02月15日, The Kobe journal of medical sciences, 62 (5), E114-E119 - E119, 英語, 国内誌

    [査読有り]

    研究論文(学術雑誌)

  • T. Hasegawa, S. Kawabata, D. Takeda, E. Iwata, I. Saito, S. Arimoto, A. Kimoto, M. Akashi, H. Suzuki, T. Komori

    The purpose of this study was to retrospectively investigate the outcomes of Brånemark System Mk III TiUnite/Groovy implants placed in patients at Kobe University Hospital. Various risk factors for implant failure, including mechanical coupling, were investigated by univariate and multivariate analysis. The predictive variables investigated included age, sex, smoking habit, general health, history of radiation therapy, application of a dentomaxillary prosthesis, type of prosthesis, use of alveolar bone augmentation, site of implant insertion, mechanical coupling between implants, and the length and diameter of the implants. Of the 907 implants investigated, only 23 were unsuccessful the overall survival rate was 96.7%. Increased age, radiation therapy, application of a removable prosthesis or dentomaxillary prosthesis, lack of mechanical coupling between implants, and shorter implants (≤8.5 mm) were significant risk factors for implant failure according to univariate analysis (P <  0.05). Multivariate analysis identified a significant association (P <  0.05) between dental implant failure and a lack of mechanical coupling between implants (odds ratio 6.88) and shorter implants (≤8.5 mm) (odds ratio 3.43). The findings of this study demonstrated multivariate relationships between various risk factors and dental implant failure.

    Churchill Livingstone, 2017年02月01日, International Journal of Oral and Maxillofacial Surgery, 46 (2), 267 - 273, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Takumi Hasegawa, Yasuyuki Shibuya, Daisuke Takeda, Eiji Iwata, Izumi Saito, Yasumasa Kakei, Akiko Sakakibara, Masaya Akashi, Tsutomu Minamikawa, Takahide Komori

    PURPOSE: The objectives of this study were to retrospectively describe the characteristics and outcomes of patients with oral squamous cell carcinoma (OSCC) with level IV/V metastases, and to evaluate the multivariate relationships among potential risk factors for metastasis and prognosis. MATERIALS AND METHODS: We evaluated 291 patients (178 men and 113 women; mean age, 65.9 ± 13.5 years). Clinicopathological data, time of development of level IV/V metastases, and clinical course were investigated. RESULTS: Twenty-three patients (7.9%) developed level IV/V metastases. The 3-year overall survival rates when level IV/V metastasis first developed were 27.3% upon initial treatment, 57.1% when metachronous neck metastasis developed, and 40.0% when the tumor recurred. Oral tongue tumor subsite, high N staging, neck dissection when metachronous neck metastasis developed, as well as recurrence were independent risk factors for level IV/V metastasis. CONCLUSION: We demonstrate here the multivariate relationships among the risk factors indicated above for level IV/V metastasis and their prognostic significance for patients with OSCC. Oral tongue tumors, high N staging, and neck dissection upon the occurrence of metachronous neck metastasis or recurrence were risk factors for level IV/V metastasis and positive extracapsular spread, presence of multiple lymph metastases, and moderate or poor differentiation were poor prognostic factors.

    CHURCHILL LIVINGSTONE, 2017年01月, Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery, 45 (1), 145 - 149, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Akiko Sakakibara, Shunsuke Sakakibara, Junya Kusumoto, Daisuke Takeda, Takumi Hasegawa, Masaya Akashi, Tsutomu Minamikawa, Kazunobu Hashikawa, Hiroto Terashi, Takahide Komori

    OBJECTIVES: Transient receptor potential cation channel (subfamily V, members 1-4) (TRPV1-4) are expressed in skin and neurons and activated by external stimuli in normal mucosae of all oral cavity sites. The oral cavity is exposed to various stimuli, including temperature, mechanical stimuli, chemical substances, and changes in pH, and, notably, the risk factors for oncogenic transformation in oral squamous epithelium are the same as the external stimuli received by TRPV1-4 receptors. Hence, we examined the relationship between oral squamous cell carcinoma (SCC) and TRPV1-4 expression. MATERIALS AND METHODS: Oral SCC patients (n = 37) who underwent surgical resection were included in this study. We investigated the expression of TRPV1-4 by immunohistochemical staining and quantification of TRPV1-4 mRNA in human oral mucosa. In addition, we compared the TRPV1-4 levels in mucosa from patients with SCC to those in normal oral mucosa. RESULTS: The receptors were expressed in oral mucosa at all sites (tongue, buccal mucosa, gingiva, and oral floor) and the expression was stronger in epithelia from patients with SCC than in normal epithelia. Furthermore, alcohol consumption and tobacco use were strongly associated with the occurrence of oral cancer and were found to have a remarkable influence on TRPV1-4 receptor expression in normal oral mucosa. In particular, patients with a history of alcohol consumption demonstrated significantly higher expression levels. CONCLUSION: Various external stimuli may influence the behavior of cancer cells. Overexpression of TRPV1-4 is likely to be a factor in enhanced sensitivity to external stimuli. These findings could contribute to the establishment of novel strategies for cancer therapy or prevention.

    PUBLIC LIBRARY SCIENCE, 2017年, PloS one, 12 (1), e0169723, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Megumi Kishimoto, Masaya Akashi, Kazuyuki Tsuji, Junya Kusumoto, Shungo Furudoi, Yasuyuki Shibuya, Yumiko Inui, Kimikazu Yakushijin, Shinichiro Kawamoto, Atsuo Okamura, Hiroshi Matsuoka, Takahide Komori

    BACKGROUND: D-index which combines the intensity and duration of neutropenia is reported as a tool for evaluating the dynamics of neutropenia. This study aimed to analyze the relationship between D-index and oral complications (i.e., oral mucositis [OM] and odontogenic infection [OI]) during chemotherapies for hematological malignancies. METHODS: A total of 421 chemotherapeutic courses in 104 patients were analyzed. Chemotherapeutic courses in patients who finished all of the prophylactic dental treatments were defined as "treatment Finish". Chemotherapeutic courses in patients who did not finish prophylactic dental treatments were defined as "treatment not-Finish". OM was evaluated according to the Common Terminology Criteria for Adverse Events, version 4.0. D-index was compared between chemotherapeutic courses with versus without oral complications. RESULTS: D-index was significantly higher in chemotherapeutic courses with grade 1 or 2 OM (p < 0.001) than courses without OM. In contrast, higher D-index did not relate to the development of OI (p = 0.18). The occurrence of OI (p < 0.001) but not OM (p = 0.56) during chemotherapy was significantly higher in chemotherapeutic courses without the completion of dental intervention. CONCLUSIONS: Higher D-index relates to the development of OM. In contrast, OI occurs due to untreated odontogenic foci, and its occurrence does not relate to higher D-index.

    PUBLIC LIBRARY SCIENCE, 2017年, PloS one, 12 (7), e0182021, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Masaya Akashi, Kazunobu Hashikawa, Satoshi Wanifuchi, Junya Kusumoto, Manabu Shigeoka, Shungo Furudoi, Hiroto Terashi, Takahide Komori

    BACKGROUND: This study aimed to analyze differences in necrotic changes between cortical and cancellous bone in resection margins after segmental mandibulectomy for advanced mandibular osteoradionecrosis. METHODS: Anteroposterior bone specimens from eleven patients who underwent segmental mandibulectomy with simultaneous free fibula flap reconstruction for advanced osteoradionecrosis were analyzed histopathologically for the presence of necrotic bone based on the presence of blood vessels within Haversian canals. RESULTS: Ten of eleven (91%) cortices near the inferior border of the mandible at the anterior margins were necrotic. All cancellous bones at the anterior margins were viable. Seven of eleven (64%) cortices near the inferior border of the mandible at the posterior margins were necrotic. Three of eleven (27%) cancellous bones at the posterior margins were necrotic. CONCLUSION: Necrotic changes are more prevalent in cortices than in cancellous bones in mandibular osteoradionecrosis, probably due to a decrease of periosteal blood supply caused by radiotherapy.

    HINDAWI LTD, 2017年, BioMed research international, 2017, 3125842 - 3125842, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • 高齢者の外傷歯に関する臨床的検討

    古土井 春吾, 可信 雅彦, 筧 康正, 松本 耕祐, 明石 昌也, 古森 孝英

    外傷歯の特徴は年齢層で相違がある。今回われわれは、高齢者の外傷歯の特徴を明らかにする目的で、2008年1月から2015年12月までに神戸大学医学部附属病院歯科口腔外科を受診した外傷歯患者188例(497歯)を対象に調査した。対象症例の年齢を世代別に0〜12歳:43例(93歯)、13〜39歳:81例(215歯)、40〜64歳:38例(108歯)、65歳以上:26例(80歯)の4つのグループに分類した。男女比は全体では1.6:1で男性に多かったが、65歳以上では女性の比率が高かった。受傷原因では、0〜12歳と65歳以上では転倒が高い割合を示した。顎骨骨折は13〜39歳で最も多く認められ、65歳以上の割合は30.8%であった。歯の受傷様式では、全世代で不完全脱臼の頻度が高く、65歳以上では歯根破折の割合が他の世代より高かった。老齢人口は増加し続けることから、高齢者の外傷歯も増加すると予測される。高齢者の顎顔面外傷を予防するための対策の検討が必要である。(著者抄録)

    (一社)日本外傷歯学会, 2016年12月, 日本外傷歯学会雑誌, 12 (1), 53 - 59, 日本語

  • Cause and occurrence timing of osteoradionecrosis of the jaw: a retrospective study focusing on prophylactic tooth extraction.

    Satoshi Wanifuchi, Masaya Akashi, Yasuo Ejima, Hirotaka Shinomiya, Tsutomu Minamikawa, Shungo Furudoi, Naoki Otsuki, Ryohei Sasaki, Ken-Ichi Nibu, Takahide Komori

    PURPOSE: This retrospective study aimed to analyze the relationship between tooth extraction and osteoradionecrosis (ORN) occurrence. The irradiation field, dose, and time interval between radiotherapy (RT) and ORN were reviewed. We also discuss appropriate guidelines for prophylactic tooth extraction. METHODS: A total of 33 patients treated for grade ≥2 (clinical) ORN in our department from 2002 to 2014 were enrolled. The following epidemiological data were retrospectively gathered: age, sex, histological diagnosis, primary tumor sites, radiation dose, chemotherapy, site of ORN, relationship between tooth extraction and ORN occurrence, and time interval between tooth extraction and the initiation or end of RT. RESULTS: Twenty-one percent of ORN cases resulted from tooth extraction. The most common site of ORN (82 %) was the mandibular molar region. About half of ORN cases (49 %) occurred within 2 years after RT. All patients who received tooth extraction after RT developed ORN (100 %) independently of time interval between tooth extraction and the end of RT (median interval, 37.5 months; range, 27-120 months). In contrast, only 50 % of patients who received tooth extraction before RT developed ORN. There may have been an association between the irradiation field and the site of ORN development CONCLUSIONS: ORN occurrence due to tooth extraction was 21 %. Occurrence timing of ORN did not depend on time interval between tooth extraction and the end of RT. The irradiation field is certainly related to the site of ORN; therefore, prophylactic tooth extraction should be performed in consideration of the proposed radiation field and dose.

    2016年12月, Oral and maxillofacial surgery, 20 (4), 337 - 342, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Akira Kimoto, Yasuyuki Shibuya, Masaki Kobayashi, Masaya Akashi, Takumi Hasegawa, Hiroaki Suzuki, Takahide Komori

    BACKGROUND: Prostheses and dental implants are often used to aid oral rehabilitation after surgery (with/without radiotherapy) for oral cancer. However, some studies have reported that the insertion of dental implants into irradiated bone results in a higher frequency of implant failure than the insertion of such implants in nonirradiated bone. MATERIALS AND METHODS: This report describes the cases of 4 patients with oral cancer who underwent surgery and radiotherapy (total dose: 50-86 Gy) and then had dental implants inserted within the irradiated area. In each case, an ilium bone graft or a latissimus dorsi myocutaneous flap containing scapular bone was transferred to the dental implant site before the insertion of the implants. RESULTS: Twenty-three implants were inserted. After loading, 2 implants were lost, and 21 remained stable. CONCLUSION: In patients who have undergone radiotherapy for oral cancer, transferring bone grafts harvested from nonirradiated tissue to the irradiated site before implant insertion might help to improve dental implant survival rates.

    LIPPINCOTT WILLIAMS & WILKINS, 2016年10月, Implant dentistry, 25 (5), 715 - 9, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Masaya Akashi, Kazunobu Hashikawa, Hiroyuki Takasu, Kazuhiro Watanabe, Junya Kusumoto, Akiko Sakakibara, Takumi Hasegawa, Tsutomu Minamikawa, Takahide Komori

    PURPOSE: This study aimed to compare the size of skin paddles, the postoperative course, and donor site complications between primary closure and skin grafts of the free fibula flap donor site. METHODS: Thirty-five consecutive patients were enrolled. Medical records were retrospectively reviewed for risk factors for delayed healing, size of skin paddles, time to resumption of gait with a mobility aid and self-ambulation, early donor site morbidity, and late donor site complaints. RESULTS: The harvested skin paddles were significantly wider in the skin graft group than in the primary closure group (P = 0.02), with no difference in length (P = 0.1). The difference in time to resuming gait with a mobility aid was also significant (P = 0.01), but not the time to self-ambulation (P = 0.9). Two early donor site morbidities (5.7 %) and 12 late donor site complaints (34.3 %) were found. No significant difference in the incidence of early donor site morbidity was observed between two groups. Occurrence of late donor site complaints was not affected by any risk factors. CONCLUSIONS: The width of the harvested skin paddle, but not the length, is one of factors involved in donor site closure. Resumption of gait with a mobility aid, but not self-ambulation, may be delayed in skin graft patients.

    Springer Verlag, 2016年09月, Oral and maxillofacial surgery, 20 (3), 233 - 7, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Masaya Akashi, Yasuyuki Shibuya, Satoru Takahashi, Kazunobu Hashikawa, Takumi Hasegawa, Yasumasa Kakei, Noriyuki Negi, Toshinori Sekitani, Takahide Komori

    PURPOSE: The purpose of this study was to analyze jaw movement during mastication in patients who underwent mandibular reconstruction following segmental mandibulectomy, including mouth opening and mastication time, based on four-dimensional computed tomography (4D CT) images. MATERIAL AND METHODS: This study included six surgical patients, who underwent segmental mandibulectomy and simultaneous reconstruction with a free fibula osteocutaneous flap, and four controls. 4D CT was performed during mastication of a cookie to evaluate the movement of the jaw during natural function. The maximum mouth opening, mastication time, and movement of the mandibular angle during mastication were evaluated from the 4D CT images. RESULTS: 4D CT images enabled visualization of jaw movement during mastication. When compared with the controls, the maximum mouth opening during mastication and excursion of the mandibular angle, especially on the diseased side, tended to decrease in surgical patients; however, this did not occur with mastication time. The numerical differences between the diseased and nondiseased side in surgical patients tended to be higher than the crosswise differences in controls. CONCLUSION: 4D CT images revealed differences in jaw function between patients who underwent mandibular reconstruction and controls. 4D CT could be used to evaluate postoperative outcomes following mandibular reconstruction.

    CHURCHILL LIVINGSTONE, 2016年05月, Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery, 44 (5), 637 - 41, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • 高端 大希, 明石 昌也, 高橋 佑輔, 辻 和志, 南川 勉, 古森 孝英

    症例は73歳女性で、右側顎下部から口唇にかけて知覚鈍麻と疼痛を自覚した。初診時、三叉神経痛を疑いカルバマゼピンを開始した。症状の改善を認めないため、下顎神経の神経障害性疼痛を疑いプレガバリンを開始した。就寝前の断続的な激痛は軽快したが、薬剤性アレルギーに起因すると考えられる発疹を生じた。ガバペンチン、クロナゼパムに変更したが、その後も右側の知覚鈍麻は残存した。この頃より右側オトガイ部と類似した知覚鈍麻が左側オトガイ部にも出現した。初診より5ヵ月後、左側頬部から左側臼歯部歯肉に腫脹を認め、画像検査を施行した。顔面CTおよびMRIのSTIR画像で左側下顎骨周囲軟組織の腫脹を認めた。画像検査から数日後には左側頬部の腫脹が急激に増大し、緊急入院となった。左側顎下部より穿刺吸引細胞診を施行し、クロマチン増量を伴うN/C比の高い異型細胞を認め悪性腫瘍を疑った。左側臼歯部歯肉から腫瘤性病変を切開生検し、び漫性大細胞型B細胞性リンパ腫と確定診断した。R-CHOP療法を開始し、腫瘍は縮小したが、両側に及ぶ知覚鈍麻は残存している。

    (公社)日本口腔外科学会, 2016年04月, 日本口腔外科学会雑誌, 62 (4), 163 - 168, 日本語

    [査読有り]

  • Yasumasa Kakei, Masaya Akashi, Takumi Hasegawa, Tsutomu Minamikawa, Satoshi Usami, Takahide Komori

    PURPOSE: Patients with oral cancer who undergo resection with simultaneous reconstruction are presumed to be at high risk for developing venous thromboembolism (VTE) according to current criteria. The primary purpose of this retrospective study was to report the incidence of VTE after oral cancer surgery requiring primary reconstruction and to identify the potential risk factors for VTE in this population. MATERIALS AND METHODS: This retrospective study evaluated 133 consecutive patients who had undergone oral cancer resection with simultaneous reconstruction from April 2007 through December 2014. Bilateral lower-extremity venous duplex ultrasonography (VDUS) was routinely performed 2 days after surgery. Pulmonary embolism was confirmed with computed tomography. The Caprini risk score (CRS) was obtained for each patient. Patients with and without VTE were compared using the χ2 test and Student t test with some variables. Univariate predictors associated with VTE were entered into a multivariate logistic regression analysis. A P value less than .05 was regarded as indicating statistical significance. RESULTS: The incidence of VTE after oral oncologic surgery with simultaneous reconstruction was 26.3% (35 of 133 patients): deep vein thrombosis (DVT) and pulmonary embolism occurred in 2.3% (3 of 133) and DVT alone was found in 24.0% (32 of 133). Multivariate logistic regression analysis showed that only a high CRS was statistically relevant to VTE occurrence. CONCLUSIONS: Because a high incidence of VTE was found after major oral and maxillofacial surgery, lower-extremity VDUS should be undertaken in patients who undergo oral cancer surgery with simultaneous reconstruction, especially those with a high CRS.

    W B SAUNDERS CO-ELSEVIER INC, 2016年01月, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 74 (1), 212 - 7, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • A comparison of radial forearm free-flap reconstruction and non-reconstruction after partial maxillectomy

    AkashiM, ShibuyaY, TakahashiY, KusumotoJ, SakakibaraA, HasegawaT, MinamikawaT, HashikawaK, KomoriT

    2016年, J Oral Maxillofac Surg Med Pathol, 28 (2), 111 - 117, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Masaya Akashi, Yujiro Hiraoka, Takumi Hasegawa, Takahide Komori

    OBJECTIVE: This retrospective study aimed to report the incidence of neurosensory complications after third molar extraction and also to identify current problems and discuss appropriate management of these complications. METHOD: Patients who underwent extraction of deeply impacted mandibular third molars under general anesthesia were included. The following epidemiological data were retrospectively gathered from medical charts: type of neurosensory complication, treatment for complication, and outcome. RESULTS: A total 369 mandibular third molars were extracted in 210 patients under general anesthesia during this study period. Thirty-one of the 369 teeth (8.4%) in 31 patients had neurosensory complications during the first postoperative week resulting from inferior alveolar nerve damage. Neurosensory complications lasting from 1 to 3 months postoperatively included 17 cases of hypoesthesia and 8 of dysesthesia in 19 patients. Five cases of hypoesthesia and 4 of dysesthesia in 5 patients persisted over 1 year postoperatively. Sixteen of 369 teeth (4.3%) in 16 patients had persistent neurosensory complications after third molar extraction under general anesthesia. Stellate ganglion block was performed in 4 patients. Early initiation of stellate ganglion block (within 2 weeks postoperatively) produced better outcomes than late stellate ganglion block (over 6 months postoperatively). CONCLUSION: Refractory neurosensory complications after third molar extraction often combine both hypoesthesia and dysesthesia. Current problems in diagnosis and treatment included delayed detection of dysesthesia and the lack of uniform timing of stellate ganglion block. In the future, routinely inquiring about dysesthesia and promptly providing affected patients with information about stellate ganglion block might produce better outcomes.

    Bentham Science Publishers B.V., 2016年, The open dentistry journal, 10, 728 - 732, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • ロケーター・磁性バーアタッチメントによるインプラントオーバーデンチャー関連合併症

    有本 智美, 長谷川 巧実, 斉藤 泉, 岩田 英治, 武田 大介, 明石 昌也, 鈴木 泰明, 古土井 春吾, 古森 孝英

    (公社)日本顎顔面インプラント学会, 2015年11月, Japanese Journal of Maxillo Facial Implants, 14 (3), 261 - 261, 日本語

  • 岩田 英治, 明石 昌也, 後藤 育子, 古土井 春吾, 古森 孝英

    症例は68歳男性、大動脈弁狭窄症に対して大動脈弁置換術を施行した。胸腹部CT画像にて右下葉にスリガラス様不透過像と左下葉結節影を指摘され、肺腺癌と診断した。化学療法を施行し、4コース終了後の胸腹部CT画像にて左下葉結節影の増大や胸水の増量などからPDと診断した。追加治療としてシスプラチンとペメトレキセドを併用した化学療法を2週ごとに施行した。骨盤転移に対しては、ゾレドロン酸を1回、デノスマブを毎月1回投与した。食事時に口腔内の接触痛を自覚し、両側下顎臼歯部の骨露出を指摘された。保存的に経過観察していたが、接触痛の増悪を自覚した。両側下顎大臼歯部舌側に10mm大の骨出と、周囲歯肉の発赤、接触痛および軽度腫脹を認めた。薬剤関連下顎骨壊死と診断し、口腔衛生管理および局所の洗浄を行った。デノスマブ投与は中止した。体調不良により通院困難となり、多臓器不全のため初診より6ヵ月後に死亡した。

    (一社)日本口腔診断学会, 2015年10月, 日本口腔診断学会雑誌, 28 (3), 208 - 212, 日本語

    [査読有り]

  • 楠元 順哉, 古土井 春吾, 榊原 晶子, 畑 みどり, 明石 昌也, 古森 孝英

    2001年1月〜2013年12月に経験した18歳以上の壊死性筋膜炎(NF)10例(男性3例、女性7例、39〜81歳、平均65.4歳)、同時期に入院加療した重症蜂窩織炎86例(男性48例、女性38例、18〜90歳、平均56.4歳)を対象に、鑑別診断におけるLRINECスコアの有用性について検討した。NF群は女子が多く、重症蜂窩織炎は男性に多いが、両者に年齢、性別で有意差はなく、血液検査データではCRP、CreでNF群と重症蜂窩織炎間に有意差を認めた。頭頸部NFに対するLRINECスコアの有用性については、カットオフ値を6点とすると、感度90%、特異度88.4%、PPV 47.4%、NPV 98.7%、LR+7.7、LR-0.11で除外診断に有用と思われた。

    (公社)日本口腔外科学会, 2015年10月, 日本口腔外科学会雑誌, 61 (10), 505 - 512, 日本語

    [査読有り]

  • CT Evaluation of Morphology of Transferred Fibula for Implant Placement in Reconstructed Mandible

    AkashiM, ShibuyaY, WanifuchiS, KusumotoJ, SakakibaraA, KimotoA, HasegawaT, SuzukiH, HashikawaK, KomoriT

    2015年10月, Implant Dent, 24 (5), 541 - 6, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Risk factors associated with postoperative delirium after surgery for oral cancer

    HasegawaT, SaitoI, TakedaD, IwataE, YonezawaN, KakeiY, SakakibaraA, AkashiM, MinamikawaT, KomoriT

    2015年09月, J Craniomaxillofac Surg, 43 (7), 1094 - 8, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Sequential evaluation for bone union of transferred fibula flaps in reconstructed mandibles: panoramic X-ray versus computed tomography

    AkashiM, HashikawaK, KakeiY, SakakibaraA, HasegawaT, MinamikawaT, KomoriT

    2015年08月, Int J Oral Maxillofac Surg, 44 (8), 942 - 7, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Determining the location of the internal maxillary artery on ultrasonography and unenhanced magnetic resonance imaging before orthognathic surgery

    ArimotoS, HasegawaT, OkamotoN, ShioyasonoA, TateishiC, AkashiM, SuzukiH, FurudoiS, KomoriT

    2015年08月, Int J Oral Maxillofac Surg, 44 (8), 977 - 83, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Low-intensity pulsed ultrasound enhances bone morphogenetic protein expression of human mandibular fracture haematoma-derived cells

    HuangW, HasegawaT, ImaiY, TakedaD, AkashiM, KomoriT

    2015年07月, Int J Oral Maxillofac Surg, 44 (7), 929 - 35, 英語

    [査読有り]

    研究論文(学術雑誌)

  • 歯科インプラント埋入のためのCT画像を用いた移植腓骨の形態評価

    明石 昌也, 橋川 和信, 榊原 晶子, 楠元 順哉

    (一社)日本形成外科学会, 2015年06月, 日本形成外科学会会誌, 35 (6), 359 - 359, 日本語

  • Risk factors associated with distant metastasis in patients with oral squamous cell carcinoma

    HasegawaT, TanakuraM, TakedaD, SakakibaraA, AkashiM, MinamikawaT, KomoriT

    2015年06月, Otolaryngol Head Neck Surg (1979), 152 (6), 1053 - 60, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Shunsuke Sakakibara, Hiroyuki Onishi, Kazunobu Hashikawa, Masaya Akashi, Akiko Sakakibara, Tadashi Nomura, Hiroto Terashi

    Background Most free flap reconstruction complications involve vascular compromise. Evaluation of vascular anatomy provides considerable information that can potentially minimize these complications. Previous reports have shown that contrast-enhanced computed tomography is effective for understanding three-dimensional arterial anatomy. However, most vascular complications result from venous thromboses, making imaging of venous anatomy highly desirable. Methods The phase-lag computed tomography angiography (pl-CTA) technique involves 64-channel (virtually, 128-channel) multidetector CT and is used to acquire arterial images using conventional CTA. Venous images are three-dimensionally reconstructed using a subtraction technique involving combined venous phase and arterial phase images, using a computer workstation. Results This technique was used to examine 48 patients (12 lower leg reconstructions, 34 head and neck reconstructions, and 2 upper extremity reconstructions) without complications. The pl-CTA technique can be used for three-dimensional visualization of peripheral veins measuring approximately 1 mm in diameter. Conclusion The pl-CTA information was especially helpful for secondary free flap reconstructions in the head and neck region after malignant tumor recurrence. In such cases, radical dissection of the neck was performed as part of the first operation, and many vessels, including veins, were resected and used in the first free-tissue transfer. The pl-CTA images also allowed visualization of varicose changes in the lower leg region and helped us avoid selecting those vessels for anastomosis. Thus, the pl-CTA-derived venous anatomy information was useful for exact evaluations during the planning of free-tissue transfers.

    THIEME MEDICAL PUBL INC, 2015年05月, JOURNAL OF RECONSTRUCTIVE MICROSURGERY, 31 (4), 305 - 312, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Akiko Sakakibara, Tsutomu Minamikawa, Kazunobu Hashikawa, Shunsuke Sakakibara, Takumi Hasegawa, Masaya Akashi, Shungo Furudoi, Takahide Komori

    Purpose: Tissue that is resected for the treatment of oral tumors often includes salivary gland ducts. At their institution, the authors conserve and transfer as much of the salivary duct as possible during these procedures to avoid obstructive complications. Differentiating these obstructive complications from a metastatic node can be challenging and can confound subsequent oncologic management. This study compared and examined the effectiveness of salivary duct repositioning in decreasing the incidence of obstructive complications. Materials and Methods: Cases of oromandibular disease treated with salivary duct resection at Kobe University Graduate School of Medicine from 2008 to 2013 were retrospectively analyzed. Thirty-two cases (25 patients) of Wharton duct resection and 31 cases (31 patients) of Stensen duct resection were included. The incidence of complications after salivary duct repositioning, duct ligation, and retention of the sublingual gland around the Wharton duct was compared. Results: Wharton ducts were repositioned in 30 cases and ligated in 2 cases. Complications, including oral swelling at the Wharton duct, were observed in 5 cases of repositioning and 2 cases of ligation. Stensen ducts were repositioned in 9 cases and ligated in 22 cases. The only complication reported was a single case of salivary fistula after ligation. Conclusions: Salivary duct repositioning is performed to prevent blockage of physiologic salivary discharge. Complications were more frequently associated with Wharton ducts than with Stensen ducts because of the unique physiologic and anatomic characteristics of the Wharton duct. Repositioning of the salivary duct is a suitable method for preventing complications associated with the Wharton duct. (c) 2015 American Association of Oral and Maxillofacial Surgeons

    W B SAUNDERS CO-ELSEVIER INC, 2015年05月, JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 73 (5), 1003 - 1007, 英語

    [査読有り]

    研究論文(学術雑誌)

  • 頸部郭清術後に中毒性巨大結腸症を併発した偽膜性腸炎を発症した1例

    岩田 英治, 古土井 春吾, 楠元 順哉, 明石 昌也, 後藤 育子, 古森 孝英

    82歳男。左側口蓋部の腫瘤を指摘された。左側口蓋から左側上顎結節部にかけて25×15mm大の腫瘤を認め、その中心部に潰瘍を認めた。左側口蓋悪性腫瘍の診断で全身麻酔下に口蓋腫瘍切除術を施行した。摘出物の病理組織診断結果は、口蓋嚢胞腺癌であった。軽快退院となったが、外来通院中に撮影したCTにて右側頸部リンパ節に後発転移を認めた。全身麻酔下に右側根治的頸部廓清術変法を施行した。病理組織検査結果は転移が疑われるリンパ節は癌陽性および節外陰性、他リンパ節は癌陰性であった。SBT/ABPCを投与したが、炎症値の著しい上昇を認め、腹部に著明な膨満と軽度圧痛を認めた。CTにて著明な腸管拡張を認めた、中毒性巨大結腸症と診断した。バンコマイシンの経口投与に変更した。内視鏡的脱気術によるガス抜きや肛門バルーン留置による吸引にて、糞便貯留は改善した。

    (一社)日本口腔感染症学会, 2015年05月, 日本口腔感染症学会雑誌, 22 (1), 12 - 16, 日本語

    [査読有り]

  • 当院における心臓血管外科患者に対する周術期口腔機能管理

    藤 大補, 明石 昌也, 古土井 春吾, 西井 美佳, 後藤 育子, 古森 孝英

    (一社)日本口腔感染症学会, 2015年05月, 日本口腔感染症学会雑誌, 22 (1), 37 - 37, 日本語

  • 抗RANKLモノクローナル抗体(デノスマブ)投与患者に発症した顎骨壊死の1例

    岩田 英治, 明石 昌也, 長谷川 巧実, 古土井 春吾, 古森 孝英

    (一社)日本口腔感染症学会, 2015年05月, 日本口腔感染症学会雑誌, 22 (1), 41 - 42, 日本語

  • Postoperative abnormal response of C-reactive protein as an indicator for infectious complications after oral oncologic surgery with primary reconstruction

    AkashiM, FurudoiS, HashikawaK, SakakibaraA, HasegawaT, ShigetaT, MinamikawaT, KomoriT

    2015年04月, J Otolaryngol Head Neck Surg, 44, 13, 英語

    [査読有り]

    研究論文(学術雑誌)

  • T. Hasegawa, C. Tateishi, M. Asai, Y. Imai, N. Okamoto, A. Shioyasono, A. Kimoto, M. Akashi, H. Suzuki, S. Furudoi, T. Komori

    We investigated changes in the sensitivity of cutaneous points and the oral mucosa after sagittal split ramus osteotomy (SSRO) and assessed the differences between SSRO and intraoral vertical ramus osteotomy (IVRO). The subjects included in this study were 46 patients with mandibular progmathism who underwent IVRO (88 rami) and 30 patients who underwent SSRO (59 rami). An objective evaluation of the neurosensory status of each patient was completed preoperatively and at 1, 4, 8, 12, and 24 weeks postoperatively. Other variables studied for each patient included sex, age, magnitude of mandibular setback, and amount of blood loss during surgery. We found that a neurosensory recovery occurred earlier in the oral mucosa than at cutaneous points. The number of oral mucosa points showing reduced neurosensory function and neurosensory disturbance after SSRO was significantly higher than after IVRO at 1, 4, and 8 weeks (P < 0.05). The nerve recovery observed after SSRO was delayed for a longer period than that noted in our previous study of IVRO. In conclusion, we found changes in sensitivity at cutaneous points and the oral mucosa after SSRO and assessed the differences between SSRO and IVRO.

    CHURCHILL LIVINGSTONE, 2015年03月, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 44 (3), 349 - 355, 英語

    [査読有り]

    研究論文(学術雑誌)

  • 重田 崇至, 南川 勉, 明石 昌也, 長谷川 巧実, 榊原 晶子, 松井 太輝, 筧 康正, 高橋 佑輔, 渋谷 恭之, 梅田 正博, 古森 孝英

    外側咽頭後リンパ節は後咽頭隙内で椎前筋の外側、内頸動脈の内側に位置しており、鼻副鼻腔、軟口蓋、上・中咽頭からリンパ流を受け内頸静脈に輸出リンパ管を送るリンパ節で、その最上方のものはルビエールリンパ節と称される。ルビエールリンパ節へは咽頭癌からの転移がしばしばみられるが、口腔癌の転移はまれとされている。ルビエールリンパ節に転移するような口腔癌への適切な治療方法は確立されておらず、その予後は極めて不良とされている。今回後方への浸潤がないにもかかわらずルビエールリンパ節に転移を生じた口腔癌2例を経験したので報告する。2例中1例は傍咽頭隙郭清を施行し、7年経過した現在無病生存で経過良好である。後方への浸潤のない口腔癌のルビエールリンパ節への転移機序、傍咽頭隙郭清の有用性について検討を行った。(著者抄録)

    (一社)日本口腔腫瘍学会, 2015年03月, 日本口腔腫瘍学会誌, 27 (1), 1 - 6, 日本語

    [査読有り]

  • The osteogenic activity of human mandibular fracture haematoma-derived progenitor cells is affected by bisphosphonate in vitro

    Imai Y, Hasegawa T, Takeda D, Akashi M, Komori T

    2015年03月, Int J Oral Maxillofac Surg, 44 (3), 412 - 6, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Clinical Study of 19 Cases Resulting in Dental Implant Removal.

    Hiroaki Suzuki, Daiki Takahashi, Kenji Matsuo, Akira Kimoto, Kousuke Matsumoto, Takumi Hasegawa, Masaya Akashi, Takahide Komori

    Dental implant treatment is a highly anticipated therapy with widespread use. However, various accidental symptoms and complications have been reported, and we may reluctantly have to remove an implant body out of necessity. This study evaluated 19 cases (21 jaws) that resulted in removal after the enforcement of implant treatment in our hospital from January 2003 to August 2013 and clarified the details of the removals clinically for the purpose of improvement of future treatment results. Implants were removed at a higher frequency in elderly patients, particularly those 70 years of age or older. The removal rate regarding the tooth missing style was high in edentulous jaw cases in both the maxilla and mandible, and was low in defective cases of middle teeth. Regarding the duration and cause of removal, approximately half of the implants were removed due to defective primary stability within 6 months; for periods greater than 6 months, all cases except 1 jaw were removed within 30 months and many cases were due to peri-implantitis. Preoperation evaluations, primary stability of the implant body at the time of the operation, long-term observation and maintenance, and patient education are crucial to reduce the frequency of removal.

    Kobe University School of Medicine, 2015年02月17日, The Kobe journal of medical sciences, 61 (4), E102-8 - E108, 英語, 国内誌

    [査読有り]

    研究論文(学術雑誌)

  • K. Tsuji, Y. Shibuya, M. Akashi, S. Furudoi, K. Yakushijin, S. Kawamoto, A. Okamura, H. Matsuoka, T. Komori

    Various chemotherapeutic agents used in patients with hematopoietic malignancy cause serious side effects, including myelosuppression and immunosuppression. Immunosuppression makes patients more susceptible to infection, resulting in an increased risk of infectious complications, including the development of severe septicemia that may be life-threatening. It is necessary for dental staff to be familiar with an appropriate protocol in such cases and to share information about the chemotherapy with a hematologist. To verify the effectiveness of our dental intervention protocol, we conducted a prospective study on the incidence of complications for each myelosuppressive grade of chemotherapy in patients with hematopoietic malignancy. We compared the incidence of complications between treatment P (patients who finished all the dental treatments according to the protocol) and treatment Q (patients who did not) per grade (A, B, C, D) and incidence of systemic or oral findings. We also compared the incidence of oral complication related to the residual teeth between first chemo (patients who were undergoing chemotherapy for the first time) and prior chemo (not the first time). There were significant differences in inflammatory complications between treatment P and treatment Q. We found that both systemic and oral inflammatory complications increased with higher-grade myelosuppressive chemotherapy. Additionally, there was a significant difference between the incidence of oral complications related to the residual teeth between first chemo and prior chemo. Complete implementation of the dental intervention protocol was associated with fewer oral and systemic infectious and inflammatory complications in patients with hematopoietic malignancies undergoing chemotherapy. The incidence of oral and systemic complications also increased with grade of chemotherapy. These results support the validity of our dental intervention protocol. We should pay close attention to the oral state of de novo hematopoietic malignancy patients.

    SAGE PUBLICATIONS INC, 2015年02月, JOURNAL OF DENTAL RESEARCH, 94 (2), 289 - 296, 英語

    研究論文(学術雑誌)

  • Long-term follow-up study of radial forearm free flap reconstruction after hemiglossectomy

    Akashi M, Hashikawa K, Sakakibara A, Komori T, Terashi H

    2015年01月, J Craniofac Surg, 26 (1), 44 - 7, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Spindle cell carcinoma of the oral cavity: the impact of chemotherapy on pulmonary metastatic tumor doubling time

    ShigetaT, MinamikawaT, MatsuiT, KakeiY, AkashiM, HasegawaT, SakakibaraA, ShibuyaY, KomoriT

    2015年, Kobe J Med Sci, 61 (3:E), 64 - 70, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Measurement of the Total Number of Bacteria in Saliva Using Quantitative Real-Time PCR During Treatment for Head and Neck Malignancy: A Series of Cases

    GotoI, FurudoiS, AkashiM, KomoriT

    2015年, Oral Health Dent Manag, 142 (776), 英語

    [査読有り]

    研究論文(学術雑誌)

  • Evaluation and comparison of CT values in bisphosphonate-related osteonecrosis of the jaw

    ImaiY, HasegawaT, TakedaD, KusumotoJ, AkashiM, LeeSY, FurudoiS, KomoriT

    2015年, J Oral Maxillofac Surg Med Pathol, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Yasumasa Kakei, Masaya Akashi, Takashi Shigeta, Takumi Hasegawa, Takahide Komori

    Background: To maintain normal function, the lymphatic endothelium is regulated by cell-cell junctions. There have been few studies of lymphatic endothelial cell junctions using standard cell biological methods. This study had two purposes: to characterize cell junctions in cultured lymphatic endothelial cells and to investigate the effects of the inflammatory cytokine TNF-alpha on altered cell-cell junctions. Methods and Results: Cultured human dermal lymphatic endothelial cells (HDLEC) were immunostained with the tight junction marker, ZO-1, and adherens junction markers, VE-cadherin and PECAM-1. In TNF-alpha-treated HDLEC, we evaluated changes in endothelial cell junctions by immunostaining and through the use of transendothelial electrical resistance (TER). Immunofluorescence staining of HDLEC revealed heterogeneity among the endothelial cell junctions, which could be classified into continuous and discontinuous junctions. In these cell junctions, ZO-1 and VE-cadherin were co-localized. Double immunofluorescence staining revealed the broad distribution of VE-cadherin at the cell periphery, where VE-cadherin and PECAM-1 were co-localized. TNF-alpha treatment decreased TER, caused a predominance in the appearance of discontinuous junctions with a reduction in the broad distribution of VE-cadherin at the cell periphery in HDLEC. Conclusions: The results indicate a heterogeneous distribution of cell junctions in HDLEC involving continuous and discontinuous junctions. Our data also suggest that TNF-alpha alters the normal distribution of cell junctions and affects the endothelial barrier of cultured lymphatic endothelial cells. The broad distribution of VE-cadherin at the cell periphery may reflect the lymphatic permeability.

    MARY ANN LIEBERT, INC, 2014年09月, LYMPHATIC RESEARCH AND BIOLOGY, 12 (3), 136 - 143, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Sequential changes in oral dryness evaluated by a moisture-checking device in patients with oropharyngeal cancer during chemoradiotherapy: a pilot study

    Nishii M, Akashi M, Kakei Y, Hasegawa T, Minamikawa T, Furudoi S, Shibuya Y, Takahashi M, Otsuki N, Nibu K, Komori T

    2014年06月, Oral Health Dent Manag, 13 (2), 507 - 11, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Y. Shibuya, Y. Ohtsuki, C. Hirai, T. Hasegawa, M. Akashi, T. Shigeta, T. Minamikawa, T. Komori

    The purpose of this study was to determine the detailed background of cases of oral squamous cell carcinoma (OSCC) with microscopic extracapsular spread (ECS) in the cervical lymph nodes. The cases of 78 patients with primary OSCC, who attended hospital from October 2007 to July 2011 and underwent resection of the primary tumour with neck dissection, were reviewed. The subjects were classified into three categories: pN0, pN+/ECS-, and pN+/ECS+; the outcomes of pN+/ECS+ patients were compared in detail with those of the other categories. Thirty-one cases (39.7%) were pN0, 25 cases (32.1%) were pN+/ECS-, and 22 cases (28.2%) were pN+/ECS+. The 3-year overall survival rate was 82.1% in pN0, 74.1% in pN+/ECS-, and 39.8% in pN+/ECS+ (pN0 vs. pN+/ECS+, P = 0.0004; pN+/ECS- vs. pN+/ECS+, P = 0.0086). The 3-year disease-specific survival rate was 96.2% in pN0, 77.2% in pN+/ECS-, and 39.8% in pN+/ECS+ (pN0 vs. pN+/ECS+, P < 0.0001; pN+/ECS- vs. pN+/ECS+, P = 0.0038). Patients with poorly differentiated carcinoma, those with three or more ECS+ nodes, and those with ECS+ node(s) located at levels III, IV, and V, had the worst prognosis among pN+/ECS+ subjects.

    CHURCHILL LIVINGSTONE, 2014年04月, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 43 (4), 387 - 392, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Y. Imai, T. Hasegawa, D. Takeda, M. Akashi, S. Y. Lee, T. Niikura, Y. Shibuya, M. Kurosaka, T. Komori

    Low intensity pulsed ultrasound (LIPUS) stimulation is a clinically established treatment method used to accelerate long bone fracture healing; however, this method is currently not applied to mandibular fractures. In this study, we investigated the effects of LIPUS on human mandibular fracture haematoma-derived cells (MHCs) in order to explore the possibility of applying LIPUS treatment to mandibular fractures. MHCs were isolated from five patients. The cells were divided into two groups: (1) LIPUS (+) group: MHCs cultured in osteogenic medium with LIPUS treatment; and (2) LIPUS () group: MHCs cultured in osteogenic medium without LIPUS treatment. The osteogenic differentiation potential and proliferation of the MHCs were compared between the two groups. The waveform used was equal to the wave conditions of a clinical fracture healing system. The gene expression levels of ALP, OC, Runx2, OSX, OPN, and PTH-R1 and mineralization were increased in the LIPUS (+) group compared to the LIPUS () group. There were no significant differences in cell proliferation between the two groups. These findings demonstrate the significant effects of LIPUS on the osteogenic differentiation of MHCs. This study provides significant evidence for the potential usefulness of the clinical application of LIPUS to accelerate mandibular fracture healing.

    CHURCHILL LIVINGSTONE, 2014年03月, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 43 (3), 367 - 372, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Changes in the sensitivity of cutaneous points and the oral mucosa after intraoral vertical ramus osteotomy

    Hasegawa T, Tateishi C, Asano M, Takata N, Akashi M, Shigeta T, Furudoi S, Shibuya Y, Komori T

    2013年11月, Int J Oral Maxillofac Surg, 42 (11), 1454 - 61, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Preoperative MR angiography for free fibula osteocutaneous flap transfer

    Akashi M, Nomura T, Sakakibara S, Sakakibara A, Hashikawa K

    2013年09月, Microsurgery, 33 (6), 454 - 9, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Masaya Akashi, Yasuyuki Shibuya, Junya Kusumoto, Shungo Furudoi, Yumiko Inui, Kimikazu Yakushijin, Atsuo Okamura, Hiroshi Matsuoka, Takahide Komori

    Background: Odontogenic diseases can be a risk factor for life-threatening infection in patients with hematologic malignancies during chemotherapy that induces myelosuppression of variable severity. Previous studies noted the necessity of the elimination of all odontogenic foci before hematopoietic stem cell transplantation. To enable planning for the adequate dental intervention, the oral medicine team must understand the general status of patient and the intensity of the chemotherapy, which is sometimes difficult to be fully appreciated by dental staff. Therefore, a simplified grading would facilitate the sharing of information between hematologists, dentists and oral hygienists. This study aimed to introduce our myelosuppression grading of chemotherapies for hematologic malignancies and analyze the timing of occurrence of severe odontogenic infection.Methods: 37 patients having received various chemotherapies for hematologic malignancies were enrolled. The chemotherapy regimens were classified into four grades based on the persistency of myelosuppression induced by chemotherapy. Mild myelosuppressive chemotherapies were classified as grade A, moderate ones as grade B, severe ones as grade C, and chemotherapies that caused severe myelosuppression and persistent immunodeficiency (known as conditioning regimens for transplant) as grade D. The timing of occurrence of severe odontogenic infection was retrospectively investigated.Results: Two patients (5.4%) had severe odontogenic infections after grade B or C chemotherapy. One occurred after extraction of non-salvageable teeth the other resulted from advanced periodontitis in a tooth that could not be extracted because of thrombocytopenia. Both were de novo hematologic malignancy patients. During grade D chemotherapy, no patients had severe odontogenic infections.Conclusions: The simplified grading introduced in this study is considered a useful tool for understanding the myelosuppressive state caused by chemotherapy and facilitating communication between medical and dental staff. During the period around the primary chemotherapy, especially for de novo hematologic malignancy patients who often received grade B to C myelosuppression chemotherapy, caution should be exercised for severe odontogenic infection by the oral medicine team, irrespective of whether invasive treatment is to be performed. © 2013 Akashi et al. licensee BioMed Central Ltd.

    2013年08月19日, BMC Oral Health, 13 (1), 41, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Risk factors associated with inferior alveolar nerve injury after extraction of the mandibular third molar-a comparative study of preoperative images by panoramic radiography and computed tomography

    Hasegawa T, Ri S, Shigeta T, Akashi M, Imai Y, Kakei Y, Shibuya Y, Komori T

    2013年07月, Int J Oral Maxillofac Surg, 42 (7), 843 - 51, 英語

    [査読有り]

    研究論文(学術雑誌)

  • がん切除後下顎骨再建における再建理論「CATコンセプト」 臨床症例における実践結果

    橋川 和信, 明石 昌也, 野村 正, 寺師 浩人

    (一社)日本頭頸部癌学会, 2013年05月, 頭頸部癌, 39 (2), 166 - 166, 日本語

    [査読有り]

  • Tight junction dysfunction in the stratum granulosum leads to aberrant stratum corneum barrier function in claudin-1-deficient mice

    Sugawara T, Iwamoto N, Akashi M, Kojima T, Hisatsune J, Sugai M, Furuse M

    2013年04月, J Dermatol Sci, 70 (1), 12 - 8, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Oral squamous cell carcinoma with multiple neck metastases-cases with more than ten pathologically positive lymph nodes in the unilateral side

    Shibuya Y, Hasegawa T, Akashi M, Shigeta T, Minamikawa T, Komori T

    2013年04月, J Oral Maxillofac Surg, 71 (4), 793 - 7, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Yasumasa Kakei, Masaya Akashi, Hideki Komatsubara, Tsutomu Minamikawa, Takahide Komori

    Objectives: Secondary malignancy in the oral mucosa is recognized as one of the most serious complications in patients who received allogenic hematopoietic stem cell transplantation (HSCT). However, potential risk factors associated with carcinogenesis after HSCT that have been reported remain elusive. We experienced a rare case of secondary malignancies of the oral and esophageal mucosa and analyzed the expression of tumor suppressor gene product p16. Case report: A 35-year-old male had malignant lesions of the oral and esophageal mucosa two years after HSCT. Partial maxillectomy and endoscopic submucosal dissection were performed. Immunohistochemical analyses revealed that the tumor cells of malignant and premalignant lesions of the oral cavity and esophagus but not keratosis were positive for p16. Conclusions: Pathological examinations with p16 immunohistochemistry may contribute to an early diagnosis of secondary malignancy after HSCT.

    BIOMED CENTRAL LTD, 2012年06月, HEAD & NECK ONCOLOGY, 4, 38, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Masaya Akashi, Tomohito Higashi, Sayuri Masuda, Takahide Komori, Mikio Furuse

    Cell-cell junctioris play crucial roles in the organization and function of epithelial and endothelial cellular sheets. Here, we have identified the protein product for KIAA1462 gene, whose single nucleotide polymorphisms (SNPs) have recently reported to be associated with coronary artery disease, as a novel component of cell-cell junctions. We propose the name of KIAA1462 protein junctional protein associated with coronary artery disease (JCAD). JCAD is a similar to 145 kDa protein without any known domains but contains a proline-rich region. Immunolocalization studies revealed that JCAD is specifically localized at cell-cell junctions in endothelial cells but not in epithelial cells. The accumulation of JCAD at cell-cell junctions in cultured endothelial cells was impaired by RNAi-mediated suppression of VE-cadherin expression. In cell adhesion-deficient mouse L fibroblasts, JCAD was recruited to cell-cell contacts when cadherin-mediated cell-cell adhesion was induced. These results indicate that JCAD is a component of VE-cadherin-based cell-cell junctions in endothelial cells. This study also suggests the implication of endothelial cell-cell adhesion in coronary artery disease. (C) 2011 Elsevier Inc. All rights reserved.

    ACADEMIC PRESS INC ELSEVIER SCIENCE, 2011年09月, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 413 (2), 224 - 229, 英語

    研究論文(学術雑誌)

  • 明石 昌也, 李 進彰, 石田 佳毅, 中川 直美, 柳川 由美恵, 古森 孝英

    25歳女。歯科で左側上顎埋伏智歯の抜歯中に切削器具が破折し、洞内に迷入した。当日夜の当院初診時、パノラマX線で上顎洞後壁相当部に金属様不透過像を認めた。洞底線の不明瞭な部分を認めたが、明らかな交通はなかった。翌日再診時のCTでは、上顎洞内の異物は鼻腔側に移動していた。感染の可能性などを説明し、抜歯による疼痛や精神的疲労、本人・家族の希望もあり、同日全身麻酔下に異物除去術を施行した。歯肉頬移行部に横切開を加え、犬歯窩相当部の上顎洞前壁を開削し洞内へアプローチしたが、異物は発見できなかった。自然孔からの排出による誤飲誤嚥を疑い、術中に胸腹部X線撮影を行ったところ、胃内に金属様不透過像を認めた。外科・内科医の協力で、内視鏡下に胃の幽門部付近に停滞していた異物を摘出した。摘出物は長さ7mmの歯科用切削バーの破折片であった。術後合併症はなく、経過順調である。

    (公社)日本口腔外科学会, 2008年03月, 日本口腔外科学会雑誌, 54 (3), 210 - 213, 日本語

    [査読有り]

  • 明石 昌也, 李 進彰, 石田 佳毅, 中川 直美, 柳川 由美恵, 古森 孝英

    (NPO)日本口腔科学会, 2007年01月, 日本口腔科学会雑誌, 56 (1), 189 - 190, 日本語

  • A clinical study of temporomandibular joint disorders -An analysis based on the Japanese subtype classification

    Yasuyuki Shibuya, Junichiro Takeuchi, Noriko Ikehata, Masaya Akashi, Tsuyoshi Fujita, Satoshi Yokoo, Masahiro Umeda, Takahide Komori

    In this study, cases of temporomandibular joint disorder (TMJD) were analyzed based on the subtype classification established by Japanese Society for the Temporomandibular Joint (JSTMJ) in 2001. The subject of our investigation consisted of cases who visited to the department of Oral and Maxillofacial Surgery of Kobe University Hospital in 2002 because of TMJD. Among them, any cases with no physical examination or strong psychogenic factors related to their symptoms were excluded. As a result, a total of 195 cases were investigated in this study. These cases consisted of 50 males and 145 females with a mean age of 38.1 years, and they were classified as type I (28 cases), type II (7 cases), type IIIa (91 cases), type IIIb (44 cases) and type IV (25 cases). The most frequently used therapy of the all diagnostic categories was a stabilization type of splint therapy (99 cases), and medication with muscle relaxants (52 cases) or analgesics (50 cases) ranked thereafter. All cases were followed until December 2004, and the results of the treatment were classified into 5 categories of 'improved', 'effective', 'no change', 'deteriorated' and 'discontinued'. No cases with a deterioration of symptoms were observed, while 109 cases (55.9%) were assessed as either 'improved' or 'effective'.

    2007年, Kobe Journal of Medical Sciences, 53 (2), 63 - 70, 英語

    [査読有り]

    研究論文(学術雑誌)

  • 梅田 正博, 李 進彰, 石田 佳毅, 中川 直美, 明石 昌也, 大川 修司, 西松 成器, 南川 勉, 古森 孝英

    エホバの証人は宗教上の理由から輸血を拒否し,比較的侵襲の大きな手術を予定する際にさまざまな問題を生じる可能性がある.今回われわれは,2名のエホバの証人患者に口腔癌手術を行ったので報告する.症例1は64歳女性の下顎歯肉癌(T2N2bM0)で,頸部郭清,下顎骨辺縁切除を施行した.出血量は300gであった.症例2は50歳男性の舌癌(T2N2bM0)で,頸部郭清,舌半側切除,大胸筋皮弁移植を施行した.出血量は445gであった.いずれも術前に患者と免責証書を取り交わし,手術は低血圧麻酔下で行われた.エホバの証人の治療に関する問題点についても考察を行った(著者抄録)

    (一社)日本口腔腫瘍学会, 2006年03月, 日本口腔腫瘍学会誌, 18 (1), 1 - 5, 日本語

    [査読有り]

  • 榎本 由依, 橘 進彰, 格谷 僚, 岩田 英治, 高田 直樹, 明石 昌也

    71歳女性。右側頬部の腫脹と開口障害を主訴に前医より歯性感染症を疑われ、当院へ紹介となった。初診時、右側頬部皮膚の腫脹と一致して、右側頬粘膜にも腫脹が認められたが、原因となる歯科疾患はみられなかった。その後、詳細な問診で4年前に両側頬部にバイオアルカミドによる除皺術を受けたことが判明した。MRI所見より頬部の皮膚充填材への感染に起因する右側頬部蜂窩織炎と診断され、治療としてSBT/ABPCの投与を行った結果、炎症所見や腫脹、開口障害の改善が得られた。

    (公社)日本口腔外科学会, 2021年07月, 日本口腔外科学会雑誌, 67 (7), 447 - 451, 日本語

  • 生体腎移植後患者に発症した歯性感染症によるガス壊疽の1例

    高田 直樹, 橘 進彰, 岩田 英治, 榎本 由依, 明石 昌也

    症例は68歳女性で、11年前に高血圧性腎硬化症を発症し、5年前に夫をドナーとする生体腎移植を受けていた。今回、左側下顎部の疼痛と腫脹を主訴に近在歯科医院を受診し、抗菌薬内服で症状改善を認めないため、精査加療目的に当科を紹介され救急受診した。画像所見より左側頭頸部ガス壊疽と診断し、側頭部および顎下部より切開排膿術、左側下顎第一小臼歯および左側下顎第一から第三大臼歯の抜歯を施行した。側頭筋、内側翼突筋、咬筋の壊死部はデブリードメントを行い、下顎骨の内外側で側頭部と顎下部をそれぞれ交通させペンローズドレーンを計3本留置した。また、初診時血液検査結果より急性腎不全が疑われたため、抗菌薬はスルバクタム・アンピシリン3g/日とクリンダマイシン1.2g/日を併用し経静脈投与した。切開部からの排膿はほぼ消失したため第27病日にすべてのドレーンを抜去し、第39病日に軽快退院となった。

    (一社)日本口腔感染症学会, 2020年11月, 日本口腔感染症学会雑誌, 27 (2), 61 - 66, 日本語

  • 全身麻酔導入時にロクロニウムによるアナフィラキシーをきたした1例

    高田 直樹, 橘 進彰, 高井 美玲, 榎本 由依, 岩田 英治, 黄 文蘇, 明石 昌也

    全身麻酔中のアナフィラキシーの原因は筋弛緩薬によるものが最も多い。今回われわれは、全身麻酔導入後にロクロニウムによるアナフィラキシーをきたした1例を経験したのでその概要を報告する。患者は41歳、女性。両側下顎智歯抜歯依頼にて当科紹介初診となった。全身麻酔下での両側下顎埋伏智歯抜歯術を予定した。プロポフォール、レミフェンタニル、ロクロニウムで導入を行ったが、59/32mmHgへ血圧が低下した。昇圧薬を投与したが血圧上昇を認めなかったため、アナフィラキシーが疑われた。皮膚症状も出現し、アドレナリン、ステロイド、クロルフェニラミンを投与した。バイタルサインが安定したため手術延期を決定し、抜管後ICU管理とした。二相性反応なく、バイタルサインは安定していたため翌日当科退院となった。79日後にアレルギーテストを行い、原因物質はロクロニウムとの診断であった。再手術時は筋弛緩薬を使用せず全身麻酔を行ったが、術中、術後とも問題なく順調に経過した。アナフィラキシーの原因物質を特定できたことで、アナフィラキシーを予防することが可能であった。治療に際しては医科関連各科と連携していくことが重要である。(著者抄録)

    (一社)日本有病者歯科医療学会, 2020年08月, 有病者歯科医療, 29 (3), 75 - 80, 日本語

  • Ken Yoshihara, Junichi Ikenouchi, Yasushi Izumi, Masaya Akashi, Shoichiro Tsukita, Mikio Furuse

    Mammalian ortholog of Scribble tumor suppressor has been reported to regulate cadherin-mediated epithelial cell adhesion by stabilizing the coupling of E-cadherin with catenins, but the molecular mechanism involved remains unknown. In this study, we investigated the relationship between the localization of mouse Scribble at cadherin-based adherens junctions (AJs) and its phosphorylation state. Immunofluorescence staining confirmed that Scribble was localized at AJs as well as at the basolateral plasma membrane in epithelial cells. We found that Scribble was detected as two bands by Western blotting analysis and that the band shift to the higher molecular weight was dependent on its phosphorylation at Ser 1601. Triton X-100 treatment extracted Scribble localized on the basolateral membrane but not Scribble localized at AJs in cultured epithelial cells, and the Triton X-100-resistant Scribble was the Ser 1601-unphosphorylated form. Conversely, an in-house-generated antibody that predominantly recognized Ser 1601-phosphorylated Scribble only detected Scribble protein on the lateral plasma membrane. Furthermore, Ser 1601-unphosphorylated Scribble was selectively coprecipitated with E-cadherin-catenin complexes in E-cadherin-expressing mouse L fibroblasts. Taken together, these results suggest that the phosphorylation state of Scribble regulates its complex formation with the E-cadherin-catenin system and may control cadherin-mediated cell-cell adhesion. (C) 2010 Elsevier Inc. All rights reserved.

    ELSEVIER INC, 2011年02月, EXPERIMENTAL CELL RESEARCH, 317 (4), 413 - 422, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Eiji Iwata, Akira Tachibana, Junya Kusumoto, Takumi Hasegawa, Ryo Kadoya, Yui Enomoto, Naoki Takata, Masaya Akashi

    PURPOSE: The purpose of this study was to investigate the risk factors associated with post-extraction persistent bleeding in patients on warfarin or direct-acting oral anticoagulants (DOACs) and the ability of risk scores to predict post-extraction bleeding. METHODS: Three hundred ninety-one patients taking warfarin or DOACs underwent tooth extractions. Various risk factors for post-extraction bleeding, including number of tooth extraction, with antiplatelet therapy, and risk scores, were investigated by univariate and multivariate analyses. A post-extraction bleeding was classified into grades 1-3. RESULTS: The incidence of post-extraction bleeding was 26.8% (77 out of 287 patients; grade 1: 63, grade 2:14) in patients taking warfarin, and 26.0% (27 out of 104 patients; grade 1: 20, grade 2:7) in patients taking warfarin DOACs. Multivariate analyses showed that multiple teeth extractions and HAS-BLED scores (above 3 points) in patients taking warfarin, and only multiple teeth extractions in patients taking DOAC, were significantly associated with post-extraction bleeding, respectively. CONCLUSION: Most of the post-extraction bleedings were grade 1, which can be stopped by eligibly pressing gauze by surgeons. If patients taking anticoagulants are scheduled to undergo multiple teeth extractions or their HAS-BLED score are above 3 points (if warfarin), we recommend informing patients risk of post-extraction bleeding before operation, taking carefully hemostasis, and instructing patients to bite down accurately on the gauze for longer than usual.

    2022年01月19日, Oral and maxillofacial surgery, 英語, 国際誌

    研究論文(学術雑誌)

  • 筧 康正, 永井 洋士, 長谷川 巧実, 明石 昌也

    わが国における臨床研究環境は近年著しく変化している。なかでも2018年4月1日に臨床研究法が施行されたことは大きな転換点といえる。その背景として2013年から2014年にかけて、ディオバン事件を代表とする臨床研究に関する不適切な事案が複数生じたことが挙げられる。それらの臨床研究では、複数の大学機関が関連していたデータ操作・不透明な奨学寄附金を通じた研究者と製薬企業との関係性が大きくクローズアップされ、社会問題化した。これらの研究不正に鑑みて、厚労省は、臨床研究の信頼の回復のためには法規制が必要との結論に達し、倫理指針の改定・厳格化を経て臨床研究法施行の運びとなった。臨床研究に関わる全てのものにとって本法の要請を理解し、適切に対応することが求められている一方で、本法を理解するための文書類の多さや手続きの煩雑さなど、研究者の負担が大きく増えたことから、臨床試験の停滞や萎縮を招いている。本法の大きな特徴として、研究責任医師に臨床研究の責任が集約されたこと、研究者は厚労省が認定した認定臨床研究審査委員会を通して試験計画を厚労省に届けること、利益相反の流れが詳細に定められたことなどが挙げられる。本報告では臨床研究倫理における臨床研究法成立までの臨床研究環境の変化について述べたうえで、臨床研究法について概説する。(著者抄録)

    (一社)日本口腔腫瘍学会, 2021年12月, 日本口腔腫瘍学会誌, 33 (4), 159 - 163, 日本語

  • Rika Amano-Iga, Takumi Hasegawa, Daisuke Takeda, Aki Murakami, Nanae Yatagai, Izumi Saito, Satomi Arimoto, Yasumasa Kakei, Akiko Sakakibara, Masaya Akashi

    INTRODUCTION:  Delayed wound healing after surgery lowers the long-term quality of a patient's life and leads to discomfort and pain. However, treatments for wound healing are often difficult and have not yet been fully established. In this study, we investigated the effect of a special paste that can be administered transdermally and holds a non-gaseous carbon dioxide (CO2) source in its carrier, which can be applied to the head and neck region for wound healing in a rat skin defect model. METHODS: Forty-eight Sprague Dawley rats were randomized into control and CO2 groups. We punched a 6.2-mm wound on the back of each rat. The control rats were left untreated, whereas rats in the CO2 group were treated with the CO2 paste every day after surgery. We evaluated wound healing 3, 7, 14, and 21 days after wounding by analyzing the diameter of the wound, gene expression of inflammatory markers vascular endothelial growth factor (VEGF), transforming growth factor (TGF)-β, hypoxia-inducible factor (HIF)-1α, interleukin (IL)-1β, and IL-6 using quantitative real-time polymerase chain reaction, hematoxylin and eosin, and immunohistochemical staining patterns. RESULTS: Rats in the CO2 group showed accelerated wound healing compared to those in the control group. Furthermore, VEGF and TGF-β were overexpressed, whereas HIF-1α, IL-1β, and IL-6 were downregulated in the rats treated with CO2. Immunohistochemical analysis also revealed similar patterns of expression. CONCLUSION: Taken together, the CO2 paste promoted wound healing by regulating the hypoxic environment, reducing inflammation, and accelerating angiogenesis.

    2021年11月, Cureus, 13 (11), e19518, 英語, 国際誌

    研究論文(学術雑誌)

  • Sturge-Weber症候群に伴う口腔内化膿性肉芽腫の治療経験:術前塞栓療法と外科的切除の併用

    酒井 亜結美, 野村 正, 明石 昌也, 橋川 和信, 寺師 浩人

    57歳女性。19歳時にSturge-Weber症候群を発症し、4年前より右上歯肉に赤色病変が出現した。数ヵ月前から病変が急速に増大し、病変による咀嚼困難、構音障害を生じたため当院へ受診となった。受診時、悪臭や拍動を伴う易出血性の右上歯肉病変が口腔内を占拠し、顔面造影CTおよび血管造影検査では病変は大口蓋動脈と顔面動脈から豊富に栄養され、硬口蓋の広範囲に及んでいた。症状の緩和目的で口腔内に突出した病変を切除する方針となったが、右上歯肉病変は止血困難であることが予想されたため、まず動脈塞栓療法を行い、次いで外科的切除術が行われた。その結果、病理組織学的に化膿性肉芽腫と診断された。術後6ヵ月経過現在、病変の再増大や再出血はなく、咀嚼も構音も改善した。

    (一社)日本形成外科学会, 2021年09月, 日本形成外科学会会誌, 41 (9), 522 - 527, 日本語

  • Eiji Iwata, Junya Kusumoto, Naoki Takata, Shungo Furudoi, Akira Tachibana, Masaya Akashi

    BACKGROUND: Necrotizing fasciitis (NF) is an acute and life-threatening soft-tissue infection however rarely seen in oro-cervical region. Therefore, the details of oro-cervical NF (OCNF) are not well known. The purpose of this study was to investigate the characteristics of OCNF by comparing it with severe cellulitis of oro-cervical region (OCSC) or NF of other body regions (e.g., limb, perineum, and trunk) (BNF), respectively. MATERIALS AND METHODS: At first, various risk factors for OCNF in oro-cervical severe infection (OCSI; composed of OCNF and OCSC), including neutrophil-to-lymphocyte ratio (NLR) and Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) score, were investigated by univariate and multivariate analyses. Next, the differences between OCNF and BNF, including inflammatory markers and mortality, were investigated. RESULTS: In the present study, 14 out of 231 OCSI patients had OCNF. Multivariate analyses of OCSI patients showed that NLR ≥15.3 and LRINEC score ≥6 points were significantly related to OCNF. During the same period, 17 patients had BNF. The OCNF group had significantly higher inflammatory markers than the BNF group when diagnosis, but significantly lower clinical stages at the time and mortality as outcomes. CONCLUSION: We found that compared to BNF, OCNF can be detected at lower clinical stage by using indexes, such as NLR and LRINEC score, besides clinical findings, which may help contributing to patient's relief.

    2021年, PloS one, 16 (12), e0260740, 英語, 国際誌

    研究論文(学術雑誌)

  • 口腔ケアのエビデンスを検証するためにはどのような研究をすればよいのか アカデミア臨床研究環境のこれまで 臨床研究法施行の背景

    筧 康正, 長谷川 巧実, 明石 昌也

    (一社)日本口腔ケア学会, 2020年09月, 日本口腔ケア学会雑誌, 14 (3), 53 - 54, 日本語

  • 大腸癌術後合併症に対する周術期口腔機能管理の予防効果に関する多施設共同研究

    延原 浩, 五月女 さき子, 林田 咲, 村田 真穂, 梅田 正博, 長谷川 巧実, 明石 昌也, 山田 慎一, 栗田 浩, 小西 尚晃, 中原 寛和, 上田 順宏, 下辻 寛子, 桐田 忠昭, 中村 知寿, 渋谷 恭之, 山口 泰平, 森 和代

    (一社)日本口腔ケア学会, 2020年09月, 日本口腔ケア学会雑誌, 14 (3), 122 - 122, 日本語

  • Hirokazu Komatsu, Tatsuya Furukawa, Keisuke Iritani, Shun Tatehara, Miki Takahashi, Shinobu Iwaki, Yasumasa Kakei, Takumi Hasegawa, Masanori Teshima, Hirotaka Shinomiya, Naoki Otsuki, Kazunobu Hashikawa, Naomi Kiyota, Ryohei Sasaki, Masaya Akashi, Ken-Ichi Nibu

    OBJECTIVE: The blowing time ratio, which is the ratio of the blowing time when the nostrils are open and closed, is significantly correlated with velopharyngeal pressure, not only during speech but also during swallowing. This study aimed to further evaluate the usefulness of the blowing time ratio as a screening tool to evaluate the swallowing pressure of patients treated for oral and oropharyngeal cancers using high-resolution manometery (HRM). METHODS: Ten patients treated for oral or oropharyngeal cancer were recruited for this study. Swallowing pressures at the velopharynx, oropharynx, and upper esophageal sphincter (UES) were measured using HRM. Their correlations with the blowing time ratio were analyzed. RESULTS: The blowing time ratio was significantly correlated with the swallowing pressures of the oropharynx (CC = 0.815, p = 0.004) and the velopharynx (CC = 0.657, p = 0.039), but not of the UES. CONCLUSIONS: The present results further support our previous finding that the blowing time ratio is a useful screening tool to evaluate velopharyngeal and oropharyngeal swallowing pressures in patients treated for oral and oropharyngeal cancer.

    2022年06月, Auris, nasus, larynx, 49 (3), 477 - 483, 英語, 国際誌

    研究論文(学術雑誌)

  • Yasumasa Kakei, Takeshi Ioroi, Takahiro Ito, Yutaro Okazaki, Takumi Hasegawa, Ikuko Yano, Masaya Akashi

    BACKGROUND: Extraction of mandibular third molars is one of the most commonly performed oral surgical procedures, and nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for pain management. Oral NSAIDs are associated with adverse events such as gastrointestinal disorders, renal and hepatic dysfunction, and platelet dysfunction. Topical analgesics have been proposed as alternatives to oral and injectable medications to safely improve postoperative pain relief. We will conduct a single-center, placebo-controlled, double-blind, randomized crossover trial to assess the pain-relieving effect of an ibuprofen-containing gargle in patients undergoing extraction of mandibular third molars when compared with a placebo gargle. OBJECTIVE: This will be the first clinical study to compare the efficacy of an ibuprofen gargle with that of a placebo for relieving postoperative pain in addition to loxoprofen after mandibular third molar extraction. METHODS: This study will be performed at Kobe University Hospital. Participants (N=40) will be randomized equally to 1 of 2 groups. The ibuprofen-placebo group will receive an ibuprofen gargle on postoperative day (POD) 1 and a placebo gargle on POD 2. The placebo-ibuprofen group will receive a placebo gargle on POD 1 and an ibuprofen gargle on POD 2. Both groups will receive ibuprofen gargles on PODs 3-5 at least once daily. The primary objective is to estimate the within-subject difference on a visual analog scale (VAS) before and 5 minutes after using the ibuprofen or placebo gargle on PODs 1 and 2. The secondary objectives are to estimate the within-subject differences in ΔVAS before and 15 minutes after using the ibuprofen or placebo gargle on PODs 1 and 2, ΔVAS before and 5 or 15 minutes after using the ibuprofen gargle on PODs 3-5, overall efficacy (self-completion, 5 scales) on PODs 1-5, daily frequency of use (ibuprofen or placebo gargle and analgesics) on PODs 1-7, and the occurrence of adverse events. RESULTS: The Certified Review Board of Kobe University approved the study. The intervention was implemented in May 2021. For the primary analysis, we will calculate the mean and SD of ΔVAS5 on PODs 1 and 2 and the within-study difference in ΔVAS5. The treatment effect will be estimated by dividing the mean ΔVAS5 in the within-subject difference by 2 and calculating the P value using an unpaired t test. For the secondary analysis, we will calculate the mean and SD of ΔVAS15 on PODs 1 and 2 and the within-study difference in ΔVAS15. The treatment effect will be estimated as in the primary analysis. CONCLUSIONS: This trial will provide exploratory evidence of the efficacy and safety of an ibuprofen gargle for pain reduction after mandibular third molar extraction. TRIAL REGISTRATION: Japan Registry of Clinical Trials jRCTs051210022; https://tinyurl.com/39ej23zu. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/35533.

    2022年05月16日, JMIR research protocols, 11 (5), e35533, 英語, 国際誌

    研究論文(学術雑誌)

  • Hiroshi Nobuhara, Yasuhiro Matsugu, Sakiko Soutome, Saki Hayashida, Takumi Hasegawa, Masaya Akashi, Shin-Ichi Yamada, Hiroshi Kurita, Hirokazu Nakahara, Miyuka Nakahara, Nobuhiro Ueda, Tadaaki Kirita, Tomohisa Nakamura, Yasuyuki Shibuya, Kazuyo Mori, Taihei Yamaguchi

    BACKGROUND: Surgical site infection is a common postoperative complication of colorectal cancer surgery, and surgical site infection increases medical costs, prolongs hospitalization, and worsens long-term prognosis. Perioperative oral care has been reported to be effective in preventing postoperative pneumonia, although there are only a few reports on its effectiveness in preventing surgical site infection. This study aimed to determine the role of perioperative oral care in surgical site infection prevention after colorectal cancer surgery. METHODS: In this study, 1,926 patients with colorectal cancer from 8 institutions were enrolled; 808 patients (oral care group) received perioperative oral care at the hospital's dental clinic, and 1,118 (control group) did not receive perioperative oral care. The data were matched by propensity score to reduce bias. Ultimately, a total of 1,480 patients were included in the analysis. RESULTS: The incidence of surgical site infection was significantly lower in the oral care group than in the control group (8.4% vs 15.7%, P < .001). Multivariate logistic regression analysis revealed 4 independent risk factors for surgical site infection: low albumin level, rectal cancer, blood loss, and lack of perioperative oral care. Lack of perioperative oral care had an odds ratio of 2.100 (95% confidence interval 1.510-2.930, P < .001). CONCLUSION: These results suggest that perioperative oral care can reduce the incidence of surgical site infection after colorectal cancer resection. Perioperative oral care may have an important role in the future perioperative management of colorectal cancer as a safe and effective method of surgical site infection prevention, although further validation in prospective studies is needed.

    2022年04月06日, Surgery, 英語, 国際誌

    研究論文(学術雑誌)

  • Takumi Hasegawa, Aki Sasaki, Izumi Saito, Satomi Arimoto, Nanae Yatagai, Yujiro Hiraoka, Daisuke Takeda, Yasumasa Kakei, Masaya Akashi

    OBJECTIVES: This study aimed to retrospectively investigate the success and survival rates of dental implants used for dentomaxillary prostheses at our hospital and the risk factors associated with large bone defects. MATERIALS AND METHODS: A total of 138 external joint system implants used for dentomaxillary prostheses in 40 patients with large bone defects were included in this study. The alveolar bone at the site of implant insertion was evaluated using panoramic radiography and computed tomography. Various risk factors (demographic characteristics, dental status, and operative factors such as the employment of alveolar bone augmentation, the site, the length, and diameter of implants) for implant failure and complete implant loss were investigated using univariate and multivariate analyses. The associations between the variables and the success and survival rates of dental implants were analyzed using the multivariate Cox proportional hazard models. RESULTS: The 10-year overall success and survival rates were 81.3% and 88.4% in this study. Multivariable analysis showed that the male sex (HR 6.22), shorter implants (≤ 8.5 mm) (HR 5.21), and bone augmentation (HR 2.58) were independent predictors of success rate. Bone augmentation (HR 5.14) and narrow implants (≤ 3.3 mm) (HR 3.86) were independent predictors of the survival rate. CONCLUSION: Male sex, shorter or narrow implants, and bone augmentation were independent risk factors for dental implants used in dentomaxillary prostheses in patients with large bone defects. CLINICAL RELEVANCE: Clinicians should consider these risk factors and pay close attention to the management of these patients.

    2022年03月, Clinical oral investigations, 26 (3), 2743 - 2750, 英語, 国際誌

    研究論文(学術雑誌)

  • Nanae Yatagai, Takumi Hasegawa, Rika Amano, Izumi Saito, Satomi Arimoto, Daisuke Takeda, Yasumasa Kakei, Masaya Akashi

    INTRODUCTION: In recent years, the tumour immunosuppressive mechanism has attracted attention as a cause of tumour chemoresistance. Although chemoresistance and immunosuppression of tumours have been reported to be associated with a hypoxic environment, effective treatments to improve hypoxia in tumours have not yet been established. We have previously applied carbon dioxide (CO2) to squamous cell carcinoma and have shown that improvement in local oxygenation has an antitumour effect. However, the effects of local CO2 administration on tumour immunosuppression, chemoresistance, and combination with chemotherapy are unknown. In this study, we investigated the effects of local CO2 administration on squamous cell carcinoma and the effects of combined use with chemotherapy, focusing on the effects on tumour immunosuppressive factors. METHODS: Human oral squamous cell carcinoma (HSC-3) was transplanted subcutaneously into the back of a nude mouse, and CO2 and cisplatin were administered. After administration twice a week for a total of 4 times, tumours were collected and the expression of tumour immunosuppressive factors (PD-L1, PD-L2, and galectin-9) was evaluated using real-time polymerase chain reaction and immunostaining. RESULTS: Compared with the control group, a significant decrease in the mRNA expression of PD-L1 was observed in both, CO2-treated and combination groups. Similarly, the expression of PD-L2 and galectin-9 decreased in the CO2-treated and combination groups. Furthermore, immunostaining also showed a significant decrease in the protein expression of tumour immunosuppressive factors in the CO2-treated and combination groups. CONCLUSION: It was confirmed that the tumour immunosuppressive factors decreased due to local CO2 administration to the mouse model. CO2 administration has the potential to improve the hypoxic environment in tumours, and combined use with chemotherapy may also improve tumour immunosuppression.

    2021年, BioMed research international, 2021, 5568428 - 5568428, 英語, 国際誌

    研究論文(学術雑誌)

  • Takayuki Kodama, Manabu Shigeoka, Mari Nishio, Yu-Ichiro Koma, Masaya Akashi, Hiroshi Yokozaki

    2022年05月14日, Oral diseases, 英語, 国際誌

    研究論文(学術雑誌)

  • Junya Kusumoto, Kazunobu Hashikawa, Akiko Sakakibara, Nobuyuki Murai, Masaya Akashi

    BACKGROUND: Non-thrombotic skin paddle necrosis occasionally occurs during mandibular reconstructions with free fibula osteocutaneous flaps. The number of perforators, size of the skin paddle, and ischemia time of the flap are considered as causes of skin paddle necrosis. The importance of donor side selection has also been highlighted. This study aimed to investigate the leading cause of skin paddle necrosis and the optimal reconstructive procedure. METHODS: A total of 66 patients who underwent mandibular reconstruction using a free fibula osteocutaneous flap were retrospectively analyzed. Skin paddle necrosis, number of cutaneous perforators, size of the skin paddle, and ischemia time of the flap were investigated. An incorrect "laterality" was defined as a skin paddle (septum) covering the reconstruction plate. Donor-site morbidity was recorded. RESULTS: Skin paddle necrosis occurred in 15.2% of patients. An incorrect laterality was associated with a higher incidence of skin paddle necrosis (odds ratio, 22.0; 95% confidence interval, 2.5-195; p = .005). Donor-site morbidity was noted in 18.8% of the patients, without any significant difference in terms of the donor side with and without skin graft (p = .592). The postoperative activities of daily living were not affected. CONCLUSIONS: To prevent skin paddle necrosis, donor side selection is an important safety strategy during mandibular reconstruction with free fibula osteocutaneous flap. The postoperative activities of daily living were found to be little affected by differences in the donor side.

    2022年03月16日, Microsurgery, 英語, 国際誌

    研究論文(学術雑誌)

  • A Case of a Rare Branching Pattern in the Carotid Artery.

    Ayumi Sakai, Kazunobu Hashikawa, Akiko Sakakibara, Nobuyuki Murai, Tadashi Nomura, Masaya Akashi, Hiroto Terashi

    2022年, Eplasty, 22, ic1, 英語, 国際誌

  • Akiko Sakakibara, Takumi Hasegawa, Daisuke Takeda, Junya Kusumoto, Shunsuke Sakakibara, Masaya Akashi

    Schwannomas commonly occur in the head and neck region as acoustic neuromas. Facial nerve schwannomas are rare and usually occur in the temporal region. A 57-year-old woman presented with a mass at the right mandibular margin. Magnetic resonance imaging revealed a schwannoma located immediately caudal to the mental foramen. We were initially uncertain whether it arose from the trigeminal nerve or the facial nerve. Excision was performed under general anesthesia. The mass was encapsulated and easily detached from the surrounding tissue. The nerve of origin was identified proximal to the tumor. A facial nerve origin was confirmed as the muscles supplied by the marginal mandibular branch of the facial nerve moved on nerve stimulation. Nerve fibers were not found distal to the tumor, possibly because they had been cut during excision. We believe that this is the first report of a schwannoma arising from the peripheral facial nerve.

    2021年07月, Journal of surgical case reports, 2021 (7), rjab299, 英語, 国際誌

  • 早期舌癌治療のパラダイムシフトへ向けて-医科歯科病理の知の融合- 早期舌扁平上皮癌における頸部後発転移の新たな予測因子

    山川 延宏, 桐田 忠昭, 梅田 正博, 柳本 惣一, 大鶴 光信, 大倉 正也, 相川 友直, 太田 嘉英, 栗田 浩, 山田 慎一, 明石 昌也, 長谷川 巧, 上田 倫弘

    (一社)日本頭頸部癌学会, 2021年05月, 頭頸部癌, 47 (2), 142 - 142, 日本語

  • 膵頭十二指腸切除術における周術期口腔機能管理の術後合併症予防効果

    山口 泰平, 高島 裕之, 森田 麻希, 渋谷 恭之, 五月女 さき子, 林田 咲, 村田 真穂, 梅田 正博, 延原 浩, 長谷川 巧実, 明石 昌也, 兒島 由佳, 小西 尚晃, 中原 寛和, 山田 慎一, 栗田 浩, 森 和代, 於保 孝彦

    (一社)日本口腔ケア学会, 2020年09月, 日本口腔ケア学会雑誌, 14 (3), 114 - 114, 日本語

  • 周術期口腔ケアによる胃癌術後合併症予防効果に関する臨床的検討

    高島 裕之, 五月女 さき子, 林田 咲, 村田 真穂, 梅田 正博, 延原 浩, 長谷川 巧実, 明石 昌也, 上田 順宏, 下辻 寛子, 桐田 忠昭, 小西 尚晃, 中原 寛和, 山田 慎一, 栗田 浩, 山口 泰平, 森 和代, 渋谷 恭之

    (一社)日本口腔ケア学会, 2020年09月, 日本口腔ケア学会雑誌, 14 (3), 123 - 123, 日本語

  • Nanae Yatagai, Takumi Hasegawa, Katsusuke Kyotani, Tomohiro Noda, Rika Amano, Izumi Saito, Satomi Arimoto, Daisuke Takeda, Yasumasa Kakei, Masaya Akashi

    INTRODUCTION: Scarring and pain are postoperative complications in patients after head and neck cancer treatment; however, there is no effective treatment. These complications are affected by local blood flow disorders, and it is well known that the transcutaneous application of carbon dioxide (CO2) improves local blood flow. Previously, we have shown that the transcutaneous application of carbon dioxide causes absorption of CO2 and increase the oxygen (O2) pressure in the treated tissue; it is expected that the application of CO2 may reduce scarring and pain caused by cancer treatment. We newly introduced the CO2 paste as a new CO2 application method, which does not need to use CO2 gas directly. In this study, we aimed to apply of CO2 paste to healthy people and to investigate its usefulness, safety and feasibility by analysing the increase in blood flow and frequency of adverse events. METHODS: We applied carbon dioxide paste to skin over the sternocleidomastoid and gastrocnemius muscles of eight healthy volunteers. The changes in blood flow before and after the CO2 paste application using dynamic MRI, and changes in the vital signs were evaluated. RESULTS: In the neck area and middle layer of the lower leg, the signal intensity (SI) significantly increased 60 seconds after application. In the surface layer of the lower leg, the SI was significantly increased 60 and 300 seconds after paste application. Although mild heat was noted after the paste application, no obvious adverse events occurred. CONCLUSION: We demonstrated the increase in SI by dynamic MRI at the site of the carbon dioxide paste application, which indicates the paste application is effective in improving the blood flow.

    2022年07月22日, Medicine, 101 (29), e29511, 英語, 国際誌

    研究論文(学術雑誌)

MISC

  • 延原 浩, 五月女 さき子, 林田 咲, 梅田 正博, 長谷川 巧実, 明石 昌也, 山田 慎一, 栗田 浩, 中原 寛和, 上田 順宏, 桐田 忠昭, 中村 知寿, 渋谷 恭之, 山口 泰平, 森 和代

    (一社)日本外科感染症学会, 2020年10月, 日本外科感染症学会雑誌, 17 (5), 329 - 329, 日本語

  • 舌下神経麻痺を契機に発見された前立腺癌脳転移の1例

    佐々木 亜紀, 木本 明, 八谷 奈苗, 村上 明希, 明石 昌也

    (NPO)日本口腔科学会, 2020年09月, 日本口腔科学会雑誌, 69 (3), 245 - 245, 日本語

  • 舌に生じた腺扁平上皮癌の1例

    大堀 浩明, 筧 康正, 山下 淳也, 南川 勉, 明石 昌也

    (NPO)日本口腔科学会, 2020年09月, 日本口腔科学会雑誌, 69 (3), 248 - 248, 日本語

  • 顎骨壊死の病態機序解明

    明石 昌也

    顎骨壊死(osteonecrosis of the jaws)とは、様々な誘因により発症する顎口腔領域において最も難治性の感染性病変である。顎骨壊死の主な誘因は骨吸収抑制薬と放射線で、双方ともに抜歯や義歯性の潰瘍といった外的刺激が契機となることが多いが、歯周炎等の歯性感染症により続発して自然発症するケースもある。病態機序の解明はいまだ十全ではないものの、著者らがこれまで行なってきた研究結果について概略する。(著者抄録)

    (株)北隆館, 2020年07月, BIO Clinica, 35 (7), 680 - 683, 日本語

  • 頭頸部癌における免疫チェックポイント阻害薬後の救済化学療法についての後方視的検討

    小山 泰司, 清田 尚臣, 今村 善宣, 長谷 善明, 高倉 嗣丈, 蓼原 瞬, 入谷 啓介, 古川 竜也, 手島 直則, 四宮 弘隆, 宮脇 大輔, 明石 昌也, 佐々木 良平, 丹生 健一

    (一社)日本頭頸部癌学会, 2020年07月, 頭頸部癌, 46 (2), 174 - 174, 日本語

  • 当院における頭頸部がんに対する高用量シスプラチン併用化学放射線療法による急性腎障害の後方視的検討

    高倉 嗣丈, 今村 善宣, 小山 泰司, 長谷 善明, 四宮 弘隆, 手島 直則, 古川 竜也, 入谷 啓介, 蓼原 瞬, 宮脇 大輔, 明石 昌也, 佐々木 良平, 丹生 健一, 清田 尚臣

    (一社)日本頭頸部癌学会, 2020年07月, 頭頸部癌, 46 (2), 185 - 185, 日本語

  • 嚢胞壁の一部に異所性胃粘膜を認めた甲状舌管嚢胞の1例

    小林 正樹, 森田 麻希, 中村 健人, 中村 知寿, 水谷 友美, 菱田 純代, 青木 尚史, 加藤 伸一郎, 明石 昌也, 渋谷 恭之

    (NPO)日本口腔科学会, 2020年07月, 日本口腔科学会雑誌, 69 (2), 87 - 87, 日本語

  • 原因検索に難渋した口底蜂窩織炎の1例

    岩田 英治, 橘 進彰, 格谷 僚, 高井 美玲, 榎本 由依, 楠元 順哉, 高田 直樹, 明石 昌也

    (NPO)日本口腔科学会, 2020年07月, 日本口腔科学会雑誌, 69 (2), 119 - 120, 日本語

  • 顎骨壊死を契機として切開排膿を要した咀嚼筋隙膿瘍の検討

    下間 祐輝, 武田 大介, 佐々木 亜紀, 小林 英里奈, 八橋 明子, 齋藤 泉, 楠元 順哉, 長谷川 巧実, 古土井 春吾, 明石 昌也

    (NPO)日本口腔科学会, 2020年07月, 日本口腔科学会雑誌, 69 (2), 121 - 121, 日本語

  • 当科で歯科介入を行った高用量骨吸収抑制薬使用患者におけるMRONJ発症とリスク因子についての検討

    廣田 純也, 長谷川 巧実, 武田 大介, 筧 康正, 楠元 順哉, 榊原 晶子, 木本 明, 明石 昌也

    (NPO)日本口腔科学会, 2020年07月, 日本口腔科学会雑誌, 69 (2), 153 - 153, 日本語

  • 神戸大学医学部付属病院歯科口腔外科における抗菌薬適正使用の現状

    吉位 亮助, 楠元 順哉, 松村 恵美, 古土井 春吾, 明石 昌也

    (一社)日本口腔感染症学会, 2020年07月, 日本口腔感染症学会雑誌, 27 (1), 36 - 37, 日本語

  • エピシル口腔用液による口腔粘膜炎の疼痛緩和についての検討

    松村 恵実, 西井 美佳, 楠元 順哉, 古土井 春吾, 明石 昌也

    (一社)日本口腔感染症学会, 2020年07月, 日本口腔感染症学会雑誌, 27 (1), 38 - 38, 日本語

  • 若年女性の頬部蜂窩織炎から肺化膿症にまで進展したMRSA菌血症の1例

    大橋 雄高, 南川 勉, 岩田 英治, 松村 恵美, 古土井 春吾, 明石 昌也

    (一社)日本口腔感染症学会, 2020年07月, 日本口腔感染症学会雑誌, 27 (1), 41 - 41, 日本語

  • 頬部の皮膚充填剤により生じた頬部蜂窩織炎の1例

    榎本 由依, 橘 進彰, 岩田 英治, 高田 直樹, 明石 昌也

    (一社)日本口腔感染症学会, 2020年07月, 日本口腔感染症学会雑誌, 27 (1), 44 - 44, 日本語

  • 症状の背景にあるもの

    明石 昌也

    (一社)兵庫県歯科医師会, 2020年06月, 歯界月報, (827), 24 - 30, 日本語

  • 佐々木 崇良, 木本 明, 八谷 奈苗, 山下 淳也, 重岡 学, 明石 昌也

    (一社)日本レーザー歯学会, 2020年05月, 日本レーザー歯学会誌, 30 (1), 22 - 22, 日本語

  • 【「顎骨再建材料」】ポリ-L-乳酸

    明石 昌也

    (一社)日本歯科理工学会, 2020年01月, 日本歯科理工学会誌, 39 (1), 13 - 16, 日本語

  • 明日から役立つ!がん患者の口腔機能管理テクニック

    西井 美佳, 古土井 春吾, 松村 恵実, 楠元 順哉, 明石 昌也

    (一社)日本口腔感染症学会, 2020年01月, 日本口腔感染症学会雑誌, 26 (2), 68 - 73, 日本語

  • 口腔外科手術周術期における抗血栓療法患者に対するヘパリンブリッジの有効性に関する多施設共同後ろ向き観察研究

    後藤弘一, 山田慎一, 長谷川巧実, 吉村仁志, 五月女さき子, 冨原圭, 長谷川温, 菱田純代, 上田順宏, 傳田祐也, 岡本健二郎, 明石昌也, 近津大地, 野口誠, 太田嘉英, 藤田茂之, 藤田茂之, 渋谷恭之, 桐田忠昭, 梅田正博, 栗田浩

    2020年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 38th

  • 大腸癌術後SSIに対する周術期口腔ケアの予防効果に関する多施設共同研究

    延原浩, 五月女さき子, 林田咲, 梅田正博, 長谷川巧実, 明石昌也, 山田慎一, 栗田浩, 中原寛和, 上田順宏, 桐田忠昭, 中村知寿, 渋谷恭之, 山口泰平, 森和代

    2020年, 日本外科感染症学会雑誌(Web), 17 (5)

  • 岩田 英治, 橘 進彰, 高井 美玲, 榎本 由依, 楠元 順哉, 高田 直樹, 明石 昌也

    粘液脂肪腫は極めて稀な脂肪腫の亜型であり、本邦でこれまで報告された口腔内の発生例はわずか4例しかない。われわれは64歳男性の舌縁部に発生した粘液脂肪腫の1例を経験したので報告する。患者は舌の腫脹を主訴に紹介初診された。T1、T2強調像にて11×9×11mmの高信号を認めた。全身麻酔下に舌腫瘍摘出術を行った。病理組織学的所見は、成熟した大小不同の脂肪細胞の増殖からなり、間質に粘液腫様変化を認めたため、舌粘液脂肪腫と診断した。術後1年が経過するが再発は認めていない。(著者抄録)

    (一社)日本口腔腫瘍学会, 2019年12月, 日本口腔腫瘍学会誌, 31 (4), 203 - 206, 日本語

  • 重症心身障がい児(者)における口腔衛生状態の実態調査

    柴田 里紗, 明石 昌也, 小紫 香代, 玉村 宣尚

    国立病院総合医学会, 2019年11月, 国立病院総合医学会講演抄録集, 73回, P1 - 805, 日本語

  • 【「歯科用レーザーの現在」】軟組織に対する歯科用レーザーの活用

    木本 明, 明石 昌也, 古森 孝英

    (一社)日本歯科理工学会, 2019年09月, 日本歯科理工学会誌, 38 (3), 149 - 152, 日本語

  • 木本 明, 明石 昌也

    (NPO)日本レーザー医学会, 2019年09月, 日本レーザー医学会誌, 40 (3), 265 - 265, 日本語

  • 多剤耐性菌が検出された薬剤関連顎骨壊死患者の治療経験

    大橋 雄高, 古土井 春吾, 岸本 恵, 岩田 英治, 高橋 淳子, 楠元 順哉, 明石 昌也, 古森 孝英

    (一社)日本口腔感染症学会, 2019年06月, 日本口腔感染症学会雑誌, 26 (1), 43 - 43, 日本語

  • ゾレドロン酸の投与が奏効したび漫性硬化性下顎骨骨髄炎の1例

    佐藤 匠, 古土井 春吾, 大橋 雄高, 岸本 恵美, 岩田 英治, 楠元 順哉, 明石 昌也, 古森 孝英

    (一社)日本口腔感染症学会, 2019年06月, 日本口腔感染症学会雑誌, 26 (1), 45 - 46, 日本語

  • 頭頸部癌に対する放射線治療後の放射線性顎骨壊死に関する検討

    窪田 光, 宮脇 大輔, 佐々木 香織, 妹尾 悟史, 井上 由子, 川口 弘毅, 西川 遼, 石原 武明, 吉田 賢史, 岸本 恵美, 明石 昌也, 佐々木 良平

    (一社)日本頭頸部癌学会, 2019年05月, 頭頸部癌, 45 (2), 244 - 244, 日本語

  • 頭頸部癌に対する放射線治療後の放射線性顎骨壊死に関する検討

    窪田 光, 宮脇 大輔, 佐々木 香織, 妹尾 悟史, 井上 由子, 川口 弘毅, 西川 遼, 石原 武明, 吉田 賢史, 岸本 恵美, 明石 昌也, 佐々木 良平

    (一社)日本頭頸部癌学会, 2019年05月, 頭頸部癌, 45 (2), 244 - 244, 日本語

  • 当科におけるUnusualな再発症例について

    筧康正, 南川勉, 松田彩, 榊原晶子, 長谷川巧実, 明石昌也, 古森孝英

    2019年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 37th, 122, 日本語

  • 炭酸ガスを使用した効率的な低酸素環境改善による口腔癌の新規治療法の開発と治療抵抗性の改善効果

    長谷川巧実, 武田大介, 齋藤泉, 岩田英治, 筧康正, 榊原晶子, 明石昌也, 南川勉, 古森孝英

    2019年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 37th, 120, 日本語

  • 再建を伴う口腔癌の周術期静脈血栓塞栓症について

    筧康正, 明石昌也, 長谷川巧実, 南川勉, 古森孝英

    2019年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 37th, 112, 日本語

  • 口腔癌におけるPET‐MRI~第二報~

    瓜生開人, 南川勉, 大橋雄高, 大橋雄高, 松田彩, 武田大介, 筧康正, 松井太輝, 榊原晶子, 長谷川巧実, 明石昌也, 古森孝英

    2019年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 37th, 156, 日本語

  • 薬剤関連顎骨壊死の転帰に影響する因子についての検討

    古土井 春吾, 岩田 英治, 岸本 恵美, 高橋 淳子, 楠元 順哉, 明石 昌也, 古森 孝英

    当科で経験した薬剤関連顎骨壊死症例65例(男性15例、女性50例、平均74.9歳)を分析し、転帰に影響する因子について検討した。原疾患別では、悪性腫瘍が23例(35.4%)、骨粗鬆症が39例(60.0%)、悪性腫瘍・骨粗鬆症合併が3例(4.6%)であった。治療法はnonsurgical approach群が35例(53.8%)、conservative surgery群が23例(35.4%)、extensive surgery群が7例(10.8%)であった。転帰については、「症状消失」が38例(58.5%)、Stageが下がった「症状改善」が11例(16.9%)、「症状不変」が7例(10.8%)、Stageが上昇した「症状悪化」は5例(7.7%)、経過観察中に患者が原疾患により死亡した症例が4例(6.3%)であった。原疾患別とリスク製剤休薬・変更の可否で統計学的に有意差が認められ、悪性腫瘍と休薬・変更不可症例では「症状消失」症例が有意に少なかった。また、各Stageに占める「症状消失」症例の割合をみたところ、Stage 0:8/10例(80.0%)、Stage 1:14/17例(82.4%)、Stage 2:14/29例(48.3%)、Stage 3:2/5例(40.0%)であった。

    (一社)日本口腔感染症学会, 2018年12月, 日本口腔感染症学会雑誌, 25 (2), 71 - 77, 日本語

  • 当科におけるインプラント埋入症例と喪失リスク因子に関する後ろ向き観察研究

    長谷川 巧実, 武田 大介, 齋藤 泉, 有本 智美, 筧 康正, 明石 昌也, 鈴木 泰明, 古森 孝英

    (公社)日本顎顔面インプラント学会, 2018年11月, Japanese Journal of Maxillo Facial Implants, 17 (3), 224 - 224, 日本語

  • 当科におけるインプラント埋入症例と喪失リスク因子に関する後ろ向き観察研究

    長谷川 巧実, 武田 大介, 齋藤 泉, 有本 智美, 筧 康正, 明石 昌也, 鈴木 泰明, 古森 孝英

    (公社)日本顎顔面インプラント学会, 2018年11月, Japanese Journal of Maxillo Facial Implants, 17 (3), 224 - 224, 日本語

  • Four-dimensional CT(4DCT)による咀嚼時の下顎頭前方滑走の解析

    関谷 俊範, 明石 昌也, 筧 康正, 根宜 典行, 西尾 卓郎, 星野 貴志, 櫻井 玲, 泉谷 信行, 日下 亜起子, 古森 孝英, 村上 卓道

    (公社)日本診療放射線技師会, 2018年09月, JART: 日本診療放射線技師会誌, 65 (9), 1011 - 1011, 日本語

  • 柴田 里紗, 明石 昌也, 玉村 宜尚

    日本重症心身障害学会, 2018年08月, 日本重症心身障害学会誌, 43 (2), 343 - 343, 日本語

  • 当院における過去10年間の外傷歯症例の臨床的検討 世代別の特徴に関する分析

    佐藤 匠, 古土井 春吾, 可信 雅彦, 筧 康正, 明石 昌也, 古森 孝英

    (一社)日本外傷歯学会, 2018年07月, 日本外傷歯学会総会・学術大会プログラム・抄録集, 18回, 48 - 48, 日本語

  • 頸部リンパ節転移陽性口腔扁平上皮癌の予後因子におけるlymph node ratioの有用性に関する検討

    筧 康正, 南川 勉, 白井 達也, 大橋 雄高, 松田 彩, 松井 太輝, 榊原 晶子, 長谷川 巧実, 明石 昌也, 古森 孝英

    (NPO)日本口腔科学会, 2018年07月, 日本口腔科学会雑誌, 67 (2), 103 - 103, 日本語

  • 頸部郭清を伴う口腔癌術後合併症に関する臨床的検討

    八谷 奈苗, 長谷川 巧実, 武田 大介, 筧 康正, 松井 太輝, 明石 昌也, 南川 勉, 古土井 春吾, 古森 孝英

    (NPO)日本口腔科学会, 2018年07月, 日本口腔科学会雑誌, 67 (2), 117 - 117, 日本語

  • 膠原病を有する口腔癌症例の臨床的検討

    廣田 純也, 南川 勉, 松田 彩, 松井 太輝, 筧 康正, 榊原 晶子, 長谷川 巧実, 明石 昌也, 古森 孝英

    (NPO)日本口腔科学会, 2018年07月, 日本口腔科学会雑誌, 67 (2), 121 - 121, 日本語

  • 当科における口腔癌への緩和照射に関する臨床的検討

    松田 彩, 南川 勉, 白井 達也, 筧 康正, 松井 太輝, 長谷川 巧実, 榊原 晶子, 明石 昌也, 古森 孝英

    (NPO)日本口腔科学会, 2018年07月, 日本口腔科学会雑誌, 67 (2), 112 - 112, 日本語

  • 術後に気道閉塞を生じた口腔癌患者の3例

    香西 慎一, 松井 太輝, 筧 康正, 松田 彩, 明石 昌也, 長谷川 巧実, 南川 勉, 古森 孝英

    (NPO)日本口腔科学会, 2018年07月, 日本口腔科学会雑誌, 67 (2), 113 - 113, 日本語

  • 口腔癌術後に予定外に再度の全身麻酔による手術を要した症例の検討

    大橋 雄高, 筧 康正, 松田 彩, 松井 太輝, 榊原 晶子, 長谷川 巧実, 明石 昌也, 南川 勉, 古森 孝英

    (NPO)日本口腔科学会, 2018年07月, 日本口腔科学会雑誌, 67 (2), 110 - 110, 日本語

  • 口腔癌原発巣手術における術中迅速診断の臨床的検討

    白井 達也, 松井 太輝, 筧 康正, 大橋 雄高, 松田 彩, 長谷川 巧実, 明石 昌也, 南川 勉, 古森 孝英

    (NPO)日本口腔科学会, 2018年07月, 日本口腔科学会雑誌, 67 (2), 119 - 119, 日本語

  • 当科における過去10年間の血液培養検査に関する臨床的検討

    大橋 雄高, 古土井 春吾, 岸本 恵, 岩田 英治, 高橋 淳子, 楠元 順哉, 明石 昌也, 古森 孝英

    (一社)日本口腔感染症学会, 2018年06月, 日本口腔感染症学会雑誌, 25 (1), 48 - 48, 日本語

  • 翼突下顎隙に及ぶ蜂窩織炎に付随した舌神経知覚鈍麻に対し星状神経節ブロックを施行した1例

    白井 達也, 明石 昌也, 岸本 恵実, 古森 孝英

    (NPO)日本口腔科学会, 2018年03月, 日本口腔科学会雑誌, 67 (1), 64 - 64, 日本語

  • 頸部郭清を伴う口腔癌術後合併症に関する臨床的検討

    八谷奈苗, 長谷川巧実, 武田大介, 筧康正, 松井太輝, 明石昌也, 南川勉, 古土井春吾, 古森孝英

    2018年, 日本口腔科学会雑誌(Web), 67 (2), 117(J‐STAGE), 日本語

  • 頸部リンパ節転移陽性口腔扁平上皮癌の予後因子におけるlymph node ratioの有用性に関する検討

    筧康正, 南川勉, 白井達也, 大橋雄高, 大橋雄高, 松田彩, 松井太輝, 榊原晶子, 長谷川巧実, 明石昌也, 古森孝英

    2018年, 日本口腔科学会雑誌(Web), 67 (2), 103(J‐STAGE), 日本語

  • 膠原病を有する口腔癌症例の臨床的検討

    廣田純也, 南川勉, 松田彩, 松井太輝, 筧康正, 榊原晶子, 長谷川巧実, 明石昌也, 古森孝英

    2018年, 日本口腔科学会雑誌(Web), 67 (2), 121(J‐STAGE), 日本語

  • 放射線性下顎骨壊死の診断におけるfollow up PET‐CTの有用性

    鰐渕聡, 明石昌也, 平岡佑二郎, 武田大介, 筧康正, 松井太輝, 長谷川巧実, 南川勉, 古土井春吾, 古森孝英

    2018年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 36th, 161, 日本語

  • 皮弁再建後の再発舌癌に対して救済手術を施行した2例

    大橋雄高, 松井太輝, 筧康正, 正井友里子, 松田彩, 榊原晶子, 長谷川巧実, 明石昌也, 南川勉, 古森孝英

    2018年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 36th, 181, 日本語

  • 当科における口腔癌への緩和照射に関する臨床的検討

    松田彩, 南川勉, 白井達也, 筧康正, 松井太輝, 長谷川巧実, 榊原晶子, 明石昌也, 古森孝英

    2018年, 日本口腔科学会雑誌(Web), 67 (2), 112(J‐STAGE), 日本語

  • 超音波断層法による口腔癌頸部リンパ節転移の検討

    筧康正, 南川勉, 正井友里子, 松田彩, 松井太輝, 榊原晶子, 長谷川巧実, 明石昌也, 重田崇至, 古森孝英

    2018年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 36th, 160, 日本語

  • 舌扁平上皮癌の原発巣再発例の検討

    松井太輝, 南川勉, 大橋雄高, 正井友里子, 松田彩, 筧康正, 長谷川巧実, 明石昌也, 古森孝英

    2018年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 36th, 164, 日本語

  • 術後に気道閉塞を生じた口腔癌患者の3例

    香西慎一, 松井太輝, 筧康正, 松田彩, 明石昌也, 長谷川巧実, 南川勉, 古森孝英

    2018年, 日本口腔科学会雑誌(Web), 67 (2), 113(J‐STAGE), 日本語

  • 口腔癌術後病理minor risk症例の臨床的検討

    松田彩, 松井太輝, 正井友里子, 筧康正, 長谷川巧実, 榊原晶子, 明石昌也, 南川勉, 古森孝英

    2018年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 36th, 151, 日本語

  • 口腔癌術後に予定外に再度の全身麻酔による手術を要した症例の検討

    大橋雄高, 筧康正, 松田彩, 松井太輝, 榊原晶子, 長谷川巧実, 明石昌也, 南川勉, 古森孝英

    2018年, 日本口腔科学会雑誌(Web), 67 (2), 110(J‐STAGE), 日本語

  • 口腔癌再建術後Recipient‐site infectionの定義に関する文献レビュー

    明石昌也, 筧康正, 武田大介, 松井太輝, 榊原晶子, 長谷川巧実, 南川勉, 橋川和信, 古森孝英

    2018年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 36th, 149, 日本語

  • 口腔癌原発巣手術における術中迅速診断の臨床的検討

    白井達也, 松井太輝, 筧康正, 大橋雄高, 大橋雄高, 松田彩, 長谷川巧実, 明石昌也, 南川勉, 古森孝英

    2018年, 日本口腔科学会雑誌(Web), 67 (2), 119(J‐STAGE), 日本語

  • 上顎部分切除後の顎義歯装着に関する皮弁再建・非再建群の比較

    可信 雅彦, 筧 康正, 明石 昌也, 古森 孝英

    (一社)日本顎顔面補綴学会, 2017年12月, 顎顔面補綴, 40 (2), 55 - 55, 日本語

  • 移植腓骨へ埋入したインプラント体の周囲炎に対し炭酸ガスレーザーを適用した1例

    山下 淳也, 鈴木 泰明, 筧 康正, 木本 明, 長谷川 巧実, 明石 昌也, 松本 耕佑, 古森 孝英

    (公社)日本顎顔面インプラント学会, 2017年11月, Japanese Journal of Maxillo Facial Implants, 16 (3), 233 - 233, 日本語

  • CBCTを用いた実物大臓器立体モデル作製の基礎検討

    西尾 卓郎, 山本 慶彦, 福富 朗世, 宮本 昌宜, 香川 清澄, 根宜 典行, 日下 亜起子, 高橋 哲, 明石 昌也, 筧 康正

    (公社)日本診療放射線技師会, 2017年09月, JART: 日本診療放射線技師会誌, 64 (9), 1220 - 1220, 日本語

  • 後藤 佳代子, 柴田 里紗, 明石 昌也, 玉村 宣尚

    日本重症心身障害学会, 2017年08月, 日本重症心身障害学会誌, 42 (2), 257 - 257, 日本語

  • 顎口腔領域の重症感染症例の検討

    高橋 淳子, 古土井 春吾, 岸本 恵実, 岩田 英治, 楠元 順哉, 梶 真人, 後藤 育子, 明石 昌也, 古森 孝英

    5年間に入院加療を要した顎口腔領域の重症感染症例40例(平均61.1歳、範囲7〜90歳、男性14例)について臨床的に検討した。臨床診断名は蜂窩織炎33例、下顎骨骨髄炎5例、壊死性筋膜炎2例であり、原因疾患は根尖性歯周炎17例、辺縁性歯周炎5例、智歯周囲炎5例などで原因部位は下顎大臼歯部が多かった。起因菌として通性嫌気性菌ではStreptococcus属、偏性嫌気性菌ではPeptostreptococcus属、Prevotella属が多く、抗菌薬投与日数の中央値は5.5日であった。また、下顎臼歯部を原因とする症例は難治性になりやすく、易感染性の基礎疾患を有する症例は抗菌薬投与日数が長くなる傾向にあり、発症から当科受診までの期間が長くなるほど、CRP値が高いほど治療期間が延長する傾向がみられた。早期の消炎手術は治療期間(抗菌薬投与期間)の短縮につながると考えられた。

    (一社)日本口腔感染症学会, 2017年07月, 日本口腔感染症学会雑誌, 24 (1), 14 - 20, 日本語

  • スニチニブに関連して発症したと考えられる下顎骨壊死の1例

    岩田 英治, 古土井 春吾, 岸本 恵実, 藤林 淳子, 楠元 順哉, 後藤 育子, 明石 昌也, 古森 孝英

    (一社)日本口腔感染症学会, 2017年07月, 日本口腔感染症学会雑誌, 24 (1), 51 - 51, 日本語

  • 口腔癌術後に消化管穿孔を発症した1例

    高橋 淳子, 古土井 春吾, 岸本 恵実, 岩田 英治, 楠元 順哉, 梶 真人, 後藤 育子, 明石 昌也, 古森 孝英

    (一社)日本口腔感染症学会, 2017年07月, 日本口腔感染症学会雑誌, 24 (1), 54 - 55, 日本語

  • 結節性硬化症患者に対する口腔衛生管理の現状 エベロリムスによる口内炎への対応

    西井 美佳, 古土井 春吾, 岸本 恵実, 岩田 英治, 楠元 順哉, 明石 昌也, 古森 孝英

    (一社)日本口腔感染症学会, 2017年07月, 日本口腔感染症学会雑誌, 24 (1), 61 - 61, 日本語

  • 当院における顎骨骨髄炎外来の現状と役割

    岩田 英治, 古土井 春吾, 鰐渕 聡, 明石 昌也, 古森 孝英

    (NPO)日本口腔科学会, 2017年07月, 日本口腔科学会雑誌, 66 (2), 192 - 192, 日本語

  • 当科における予防的頸部郭清術に関する後ろ向き検討

    松田 彩, 筧 康正, 正井 友里子, 米澤 奈津季, 榊原 晶子, 長谷川 巧実, 明石 昌也, 南川 勉, 古森 孝英

    (NPO)日本口腔科学会, 2017年07月, 日本口腔科学会雑誌, 66 (2), 113 - 113, 日本語

  • 口腔扁平上皮癌における術後早期(1年以内)の予後不良例に関する臨床的検討

    正井 友里子, 南川 勉, 松田 彩, 米澤 奈津季, 筧 康正, 榊原 晶子, 長谷川 巧実, 明石 昌也, 古森 孝英

    (NPO)日本口腔科学会, 2017年07月, 日本口腔科学会雑誌, 66 (2), 114 - 114, 日本語

  • 4DCTによる咀嚼時の下顎頭前方滑走の解析

    明石 昌也, 大槻 有美, 黄 文蘇, 筧 康正, 古森 孝英

    (一社)日本顎関節学会, 2017年07月, 日本顎関節学会雑誌, 29 (Suppl.), 92 - 92, 日本語

  • 口腔癌手術における嚥下改善手術に関する臨床的検討

    筧 康正, 南川 勉, 正井 友里子, 松田 彩, 米澤 奈津季, 榊原 晶子, 長谷川 巧実, 明石 昌也, 古森 孝英

    (NPO)日本口腔科学会, 2017年07月, 日本口腔科学会雑誌, 66 (2), 114 - 114, 日本語

  • 両腋窩動脈狭窄症によりスティール症候群をきたし手指切断に至った透析患者の一例

    豊田 大祐, 加藤 敏輝, 芝田 圭佑, 齋藤 謙司, 花田 昌也, 明石 晋太郎

    (一社)日本透析医学会, 2017年05月, 日本透析医学会雑誌, 50 (Suppl.1), 756 - 756, 日本語

  • CAT分類における下顎骨切除範囲別の咀嚼機能と口腔QOLの評価

    前田 道徳, 渋谷 恭之, 明石 昌也, 古森 孝英

    (一社)日本頭頸部癌学会, 2017年05月, 頭頸部癌, 43 (2), 170 - 170, 日本語

  • 神経症状を伴った下顎放射線性顎骨壊死における下歯槽神経の病理組織学的研究

    明石 昌也, 楠元 順哉, 長谷川 巧実, 南川 勉, 橋川 和信, 古森 孝英

    (一社)日本頭頸部癌学会, 2017年05月, 頭頸部癌, 43 (2), 189 - 189, 日本語

  • 頭頸部癌化学放射線治療患者における口腔内細菌数と口腔粘膜水分量の解析

    西井 美佳, 筧 康正, 難波 渚, 澤田 麻衣子, 岩田 英治, 長谷川 巧実, 明石 昌也, 古土井 春吾, 古森 孝英

    (一社)日本口腔ケア学会, 2017年04月, 日本口腔ケア学会雑誌, 11 (3), 121 - 121, 日本語

  • チタンミニプレートと固定用スクリューの関与が疑われた乾癬様皮疹の1例

    可信 雅彦, 明石 昌也, 古土井 春吾, 古森 孝英

    (NPO)日本口腔科学会, 2017年03月, 日本口腔科学会雑誌, 66 (1), 54 - 54, 日本語

  • 神戸大学医学部附属病院における心臓血管外科患者に対する周術期口腔機能管理の現状

    藤 大補, 古土井 春吾, 明石 昌也, 西井 美佳, 古森 孝英

    2013年8月〜11月迄の4ヵ月間に、周術期口腔機能管理を依頼され、歯科口腔外科を受診した例を対象に、心臓血管外科患者に対する、周術期口腔機能管理の現状について調査した。対象期間中に循環器内科、心臓血管外科より口腔機能管理の依頼があったのは125例で、このうち心臓血管外科手術が行われた109例(男性57例、女性52例、27〜92歳、平均62.1歳)を対象とした。原疾患の内訳は弁膜疾患52例、動脈瘤32例、冠動脈疾患18例、動脈解離15例、その他24例で弁膜疾患が最も多くを占めた。JSC2008に準じ、抗菌薬の感染性心内膜炎(IE)の予防のため抗菌薬投与が行われた患者の割合はクラスI 4例、IIa 50例、IIb 4例で合計58例、IE発症リスクが低いため抗菌薬を予防投与しなかった症例は51例であった。転院などで詳細不明な10例を除いた99例中、退院時に抗凝固薬や抗血小板薬が投与された症例は68例、施行されていない症例は31例であった。

    (一社)日本口腔感染症学会, 2017年01月, 日本口腔感染症学会雑誌, 23 (2), 43 - 47, 日本語

  • 当科における予防的頸部郭清術に関する後ろ向き検討

    松田彩, 筧康正, 正井友里子, 米澤奈津季, 榊原晶子, 長谷川巧実, 明石昌也, 南川勉, 古森孝英

    2017年, 日本口腔科学会学術集会プログラム・抄録集, 71st, 181, 日本語

  • 口腔扁平上皮癌における術後早期(1年以内)の予後不良例に関する臨床的検討

    正井友里子, 南川勉, 松田彩, 米澤奈津季, 筧康正, 榊原晶子, 長谷川巧実, 明石昌也, 古森孝英

    2017年, 日本口腔科学会学術集会プログラム・抄録集, 71st, 183, 日本語

  • 口腔癌手術における嚥下改善手術に関する臨床的検討

    筧康正, 南川勉, 正井友里子, 松田彩, 米澤奈津季, 榊原晶子, 長谷川巧実, 明石昌也, 古森孝英

    2017年, 日本口腔科学会学術集会プログラム・抄録集, 71st, 183, 日本語

  • Risk factors associated with oroantral perforation during surgical removal of maxillary third molar teeth.

    Takumi Hasegawa, Akira Tachibana, Daisuke Takeda, Eiji Iwata, Satomi Arimoto, Akiko Sakakibara, Masaya Akashi, Takahide Komori

    PURPOSE: The relationship between radiographic findings and the occurrence of oroantral perforation is controversial. Few studies have quantitatively analyzed the risk factors contributing to oroantral perforation, and no study has reported multivariate analysis of the relationship(s) between these various factors. This retrospective study aims to fill this void. METHODS: Various risk factors for oroantral perforation during maxillary third molar extraction were investigated by univariate and multivariate analysis. The proximity of the roots to the maxillary sinus floor (root-sinus [RS] classification) was assessed using panoramic radiography and classified as types 1-5. The relationship between the maxillary second and third molars was classified according to a modified version of the Archer classification. The relative depth of the maxillary third molar in the bone was classified as class A-C, and its angulation relative to the long axis of the second molar was also recorded. RESULTS: Performance of an incision (OR 5.16), mesioangular tooth angulation (OR 6.05), and type 3 RS classification (i.e., significant superimposition of the roots of all posterior maxillary teeth with the sinus floor; OR 10.18) were all identified as risk factors with significant association to an outcome of oroantral perforation. CONCLUSION: To our knowledge, this is the first multivariate analysis of the risk factors for oroantral perforation during surgical extraction of the maxillary third molar. This RS classification may offer a new predictive parameter for estimating the risk of oroantral perforation.

    2016年12月, Oral and maxillofacial surgery, 20 (4), 369 - 375, 英語, 国際誌

  • 当科におけるインプラント埋入症例と喪失リスクに関する臨床的検討

    片岡 侑嗣, 長谷川 巧実, 綿越 健太, 浅井 雅敏, 有本 智美, 明石 昌也, 鈴木 泰明, 古森 孝英

    (公社)日本顎顔面インプラント学会, 2016年11月, Japanese Journal of Maxillo Facial Implants, 15 (3), 218 - 218, 日本語

  • 内視鏡支援下で上顎洞迷入インプラントの摘出後に骨造成術を行った1例

    山下 淳也, 鈴木 泰明, 筧 康正, 木本 明, 長谷川 巧実, 明石 昌也, 古森 孝英

    (公社)日本顎顔面インプラント学会, 2016年11月, Japanese Journal of Maxillo Facial Implants, 15 (3), 207 - 207, 日本語

  • 放射線性顎骨壊死症例に対する画像診断を中心とした臨床的検討

    鰐渕 聡, 明石 昌也, 岩田 英治, 楠元 順哉, 松本 耕祐, 南川 勉, 古土井 春吾, 古森 孝英

    (NPO)日本口腔科学会, 2016年07月, 日本口腔科学会雑誌, 65 (2), 130 - 131, 日本語

  • 当科における埋伏智歯抜歯後神経系合併症に対する治療法の現状

    平岡 佑二郎, 明石 昌也, 松本 耕祐, 榊原 晶子, 木本 明, 長谷川 巧実, 鈴木 泰明, 南川 勉, 古土井 春吾, 古森 孝英

    (NPO)日本口腔科学会, 2016年07月, 日本口腔科学会雑誌, 65 (2), 176 - 177, 日本語

  • 当科における歯性上顎洞炎の臨床的検討

    岩田 英治, 明石 昌也, 岸本 恵実, 藤林 淳子, 楠元 順哉, 古土井 春吾, 古森 孝英

    (NPO)日本口腔科学会, 2016年07月, 日本口腔科学会雑誌, 65 (2), 220 - 221, 日本語

  • 化学放射線療法による口腔粘膜炎の重症度を予測する因子についての検討

    岸本 恵実, 古土井 春吾, 藤林 淳子, 岩田 英治, 楠元 順哉, 梶 真人, 後藤 育子, 明石 昌也, 古森 孝英

    (一社)日本口腔感染症学会, 2016年07月, 日本口腔感染症学会雑誌, 23 (1), 21 - 22, 日本語

  • 歯性感染症が原因となった脳膿瘍の2例

    藤林 淳子, 古土井 春吾, 岸本 恵実, 岩田 英治, 楠元 順哉, 梶 真人, 後藤 育子, 明石 昌也, 古森 孝英

    (一社)日本口腔感染症学会, 2016年07月, 日本口腔感染症学会雑誌, 23 (1), 25 - 26, 日本語

  • 脳神経外科術後の顎関節症の臨床的検討

    大槻 有美, 明石 昌也, 黄 文蘇, 古森 孝英

    (一社)日本顎関節学会, 2016年07月, 日本顎関節学会雑誌, 28 (Suppl.), 111 - 111, 日本語

  • 顎関節に生じた滑膜骨軟骨腫症の1例

    黄 文蘇, 明石 昌也, 大槻 有美, 橘 進彰, 古森 孝英

    (一社)日本顎関節学会, 2016年07月, 日本顎関節学会雑誌, 28 (Suppl.), 153 - 153, 日本語

  • 下顎骨骨折の治療を行ったLennox-Gastaut症候群患児の1例

    中西 洋介, 松本 耕祐, 小守 紗也華, 長谷川 巧実, 明石 昌也, 柚鳥 宏和, 橘 進彰, 古森 孝英

    (一社)日本外傷歯学会, 2016年07月, 日本外傷歯学会総会・学術大会プログラム・抄録集, 16回, 41 - 41, 日本語

  • 当科におけるFibro-osseous lesionsの臨床的検討

    松尾 健司, 明石 昌也, 筧 康正, 松本 耕祐, 長谷川 巧実, 南川 勉, 古土井 春吾, 橘 進彰, 古森 孝英

    (NPO)日本口腔科学会, 2016年07月, 日本口腔科学会雑誌, 65 (2), 127 - 128, 日本語

  • 遺伝子解析により確定診断を得た頬粘膜MALTリンパ腫の1例

    筧 康正, 明石 昌也, 木本 明, 長谷川 巧実, 南川 勉, 古森 孝英

    (NPO)日本口腔科学会, 2016年07月, 日本口腔科学会雑誌, 65 (2), 214 - 214, 日本語

  • 当院における過去8年間の外傷歯患者の臨床統計的検討 顎骨骨折の有無と外傷歯の関係について

    可信 雅彦, 筧 康正, 明石 昌也, 古森 孝英

    (一社)日本外傷歯学会, 2016年07月, 日本外傷歯学会総会・学術大会プログラム・抄録集, 16回, 29 - 29, 日本語

  • 全身麻酔挿管中に生じる歯牙損傷の後ろ向き調査

    小守 紗也華, 筧 康正, 明石 昌也, 古森 孝英

    (一社)日本外傷歯学会, 2016年07月, 日本外傷歯学会総会・学術大会プログラム・抄録集, 16回, 30 - 30, 日本語

  • 当科における顎関節症脱臼の臨床的検討

    大槻 有美, 明石 昌也, 黄 文蘇, 筧 康正, 古森 孝英

    (一社)日本顎関節学会, 2016年07月, 日本顎関節学会雑誌, 28 (Suppl.), 130 - 130, 日本語

  • 4D-CTによる下顎再建術後患者の咀嚼の観察

    明石 昌也, 橋川 和信, 渋谷 恭之, 寺師 浩人, 古森 孝英

    (一社)日本頭頸部癌学会, 2016年05月, 頭頸部癌, 42 (2), 147 - 147, 日本語

  • 歯科インプラント埋入のためのデンタルCTを用いた移植腓骨の形態評価

    明石 昌也, 橋川 和信, 鰐渕 聡, 楠元 順哉, 長谷川 巧実, 南川 勉, 寺師 浩人, 古森 孝英

    (一社)日本頭頸部癌学会, 2016年05月, 頭頸部癌, 42 (2), 147 - 147, 日本語

  • 有本 智美, 長谷川 巧実, 岡本 奈々, 塩屋園 敦, 立石 千鶴, 明石 昌也, 鈴木 泰明, 古土井 春吾, 古森 孝英

    (NPO)日本顎変形症学会, 2016年05月, 日本顎変形症学会雑誌, 26 (2), 183 - 183, 日本語

  • 当科における心臓血管外科周術期の口腔機能管理に関する実態と今後の課題

    難波 渚, 西井 美佳, 田村 恵利, 富田 和, 長谷川 巧実, 明石 昌也, 古土井 春吾, 古森 孝英

    (一社)日本口腔ケア学会, 2016年03月, 日本口腔ケア学会雑誌, 10 (1), 199 - 199, 日本語

  • 当院における周術期口腔機能管理に関する実態調査と今後の課題

    田村 惠利, 西井 美佳, 冨田 和, 難波 渚, 長谷川 巧実, 明石 昌也, 古土井 春吾, 古森 孝英

    (一社)日本口腔ケア学会, 2016年03月, 日本口腔ケア学会雑誌, 10 (1), 225 - 225, 日本語

  • 再建プレート露出に対する二期再建術前PET/CTが膿瘍の検知に有用であった1例

    松尾 健司, 明石 昌也, 楠元 順也, 藤林 淳子, 渡邊 一博, 南川 勉, 橋川 和信, 古森 孝英

    (NPO)日本口腔科学会, 2016年03月, 日本口腔科学会雑誌, 65 (1), 69 - 69, 日本語

  • 当科におけるFibro‐osseous lesionsの臨床的検討

    松尾健司, 明石昌也, 筧康正, 松本耕祐, 長谷川巧実, 南川勉, 古土井春吾, 橘進彰, 古森孝英

    2016年, 日本口腔科学会学術集会プログラム・抄録集, 70th, 159, 日本語

  • 術前18F‐FDG PET/CT撮影での口腔癌原発巣における定量評価の有用性

    米澤奈津季, 南川勉, 北島一宏, 高橋佑輔, 筧康正, 榊原晶子, 長谷川巧実, 明石昌也, 古森孝英

    2016年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 34th, 231, 日本語

  • 口腔扁平上皮癌被膜外浸潤症例の臨床病理学的検討

    筧康正, 南川勉, 寺岡駿, 米澤奈津季, 高橋佑輔, 長谷川巧実, 明石昌也, 古森孝英

    2016年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 34th, 234, 日本語

  • 口腔扁平上皮癌患者の遠位レベル(Level4,5)への頸部リンパ節転移が予後に与える影響

    定兼啓倫, 長谷川巧実, 渋谷恭之, 渋谷恭之, 米澤奈津季, 武田大介, 高橋佑輔, 筧康正, 明石昌也, 南川勉, 古森孝英

    2016年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 34th, 221, 日本語

  • 局所的炭酸ガス投与による皮弁壊死抑制効果

    齊藤泉, 長谷川巧実, 武田大介, 岩田英治, 有本智美, 筧康正, 高橋佑輔, 榊原晶子, 明石昌也, 南川勉, 古森孝英

    2016年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 34th, 208, 日本語

  • 遺伝子解析により確定診断を得た頬粘膜MALTリンパ腫の1例

    筧康正, 明石昌也, 木本明, 長谷川巧実, 南川勉, 古森孝英

    2016年, 日本口腔科学会学術集会プログラム・抄録集, 70th, 286, 日本語

  • 移植腓骨と下顎骨の癒合における骨膜温存の重要性

    明石昌也, 筧康正, 榊原晶子, 長谷川巧実, 南川勉, 橋川和信, 古森孝英

    2016年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 34th, 208, 日本語

  • 入院加療を要した口腔頸部の重症感染症例の検討

    藤林 淳子, 古土井 春吾, 畑 みどり, 楠元 順哉, 後藤 育子, 明石 昌也, 古森 孝英

    (一社)日本口腔感染症学会, 2015年05月, 日本口腔感染症学会雑誌, 22 (1), 35 - 36, 日本語

  • 【全身疾患と抜歯-最新の知識による適切な対応-】全身疾患を有する患者の抜歯の際に注意すべき基本的事項

    古森 孝英, 明石 昌也, 鈴木 泰明, 榊原 晶子, 木本 明, 南川 勉, 長谷川 巧実, 古土井 春吾

    (株)第一歯科出版, 2015年01月, 歯科医療, 29 (1), 4 - 10, 日本語

    [招待有り]

    記事・総説・解説・論説等(学術雑誌)

  • 【全身疾患と抜歯-最新の知識による適切な対応-】循環器系疾患を有する患者の抜歯

    明石 昌也, 古森 孝英

    (株)第一歯科出版, 2015年01月, 歯科医療, 29 (1), 11 - 18, 日本語

    [招待有り]

    記事・総説・解説・論説等(商業誌、新聞、ウェブメディア)

  • 当科における頸部郭清術術後の頸部ドレーンに関する臨床的検討

    齊藤泉, 長谷川巧実, 米澤奈津季, 武田大介, 高橋佑輔, 筧康正, 松井太輝, 榊原晶子, 明石昌也, 南川勉, 古森孝英

    2015年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 33rd, 295, 日本語

  • 当科における放射線性顎骨壊死に関する臨床的検討

    鰐渕聡, 明石昌也, 筧康正, 榊原晶子, 長谷川巧実, 南川勉, 古森孝英

    2015年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 33rd, 237, 日本語

  • 当科における口腔扁平上皮癌遠隔転移例の臨床的検討とリスク因子について

    棚倉万紀子, 長谷川巧実, 米澤奈津季, 武田大介, 高橋佑輔, 筧康正, 松井太輝, 榊原晶子, 明石昌也, 南川勉, 古森孝英

    2015年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 33rd, 301, 日本語

  • 口腔癌原発巣におけるDual‐time‐point FDG PETの有用性に関する検討

    米澤奈津季, 南川勉, 高橋佑輔, 筧康正, 松井太輝, 榊原晶子, 長谷川巧実, 明石昌也, 古森孝英

    2015年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 33rd, 188, 日本語

  • 遊離腓骨皮弁移植におけるMR Angiographyと超音波検査による下肢血管解剖の術前評価

    楠元 順哉, 橋川 和信, 寺師 浩人, 明石 昌也, 榊原 晶子

    (一社)日本形成外科学会, 2014年11月, 日本形成外科学会会誌, 34 (11), 852 - 853, 日本語

  • 当科における広範囲顎骨支持型インプラント補綴の臨床統計的検討

    今井 佑輔, 長谷川 巧実, 川畑 真哉, 武田 大介, 明石 昌也, 鈴木 泰明, 古森 孝英

    (公社)日本顎顔面インプラント学会, 2014年11月, Japanese Journal of Maxillo Facial Implants, 13 (3), 128 - 128, 日本語

  • 著明な上顎洞粘膜肥厚を有する患者に洞底挙上術後インプラント治療を行った1例

    榎本 由依, 鈴木 泰明, 木本 明, 長谷川 巧実, 明石 昌也, 浅井 知子, 竹内 純一郎, 古森 孝英

    (公社)日本顎顔面インプラント学会, 2014年11月, Japanese Journal of Maxillo Facial Implants, 13 (3), 144 - 144, 日本語

  • 当科におけるインプラント242例907本埋入に関する臨床的検討

    川畑 真哉, 長谷川 巧実, 今井 佑輔, 木本 明, 明石 昌也, 鈴木 泰明, 古森 孝英

    (公社)日本顎顔面インプラント学会, 2014年11月, Japanese Journal of Maxillo Facial Implants, 13 (3), 160 - 160, 日本語

  • 歯科インプラント埋入のためのCT画像を用いた移植腓骨の形態評価

    明石 昌也, 渋谷 恭之, 鰐渕 聡, 木本 明, 長谷川 巧実, 鈴木 泰明, 古森 孝英

    (公社)日本顎顔面インプラント学会, 2014年11月, Japanese Journal of Maxillo Facial Implants, 13 (3), 166 - 166, 日本語

  • 再発胃癌切除後に生じた胸腹壁欠損に対する治療経験

    長谷川 泰子, 野村 正, 橋川 和信, 寺師 浩人, 明石 昌也, 前田 翔

    (一社)日本形成外科学会, 2014年11月, 日本形成外科学会会誌, 34 (11), 851 - 851, 日本語

    その他

  • Preformed Reconstruction plateで下顎再建を行った2症例

    竹内 惇平, 明石 昌也, 藤 大補, 高橋 佑輔, 古土井 春吾, 榊原 晶子, 南川 勉, 渋谷 恭之, 古森 孝英

    (NPO)日本口腔科学会, 2014年09月, 日本口腔科学会雑誌, 63 (4), 350 - 350, 日本語

  • 放射線性口腔粘膜炎の重症度判定の客観性を高めるための方策

    川下 由美子, 林田 咲, 船原 まどか, 齋藤 俊行, 西井 美佳, 後藤 郁子, 明石 昌也, 古土井 春吾, 古森 孝英, 梅田 正博

    (NPO)日本口腔科学会, 2014年09月, 日本口腔科学会雑誌, 63 (4), 358 - 358, 日本語

  • 造血器悪性腫瘍患者への歯科的介入に関する前向き検討

    辻 和志, 渋谷 恭之, 岸本 恵実, 明石 昌也, 古土井 春吾, 古森 孝英

    (NPO)日本口腔科学会, 2014年09月, 日本口腔科学会雑誌, 63 (4), 376 - 376, 日本語

  • 口腔癌再建術後の頸部感染評価目的でのCTの有用性

    明石 昌也, 古土井 春吾, 南川 勉, 木本 明, 榊原 晶子, 長谷川 巧実, 後藤 育子, 渋谷 恭之, 古森 孝英

    (NPO)日本口腔科学会, 2014年09月, 日本口腔科学会雑誌, 63 (4), 381 - 381, 日本語

  • ビスフォスフォネート関連顎骨壊死症例の転帰に影響する因子についての検討

    古土井 春吾, 楠元 順哉, 畑 みどり, 藤林 淳子, 梶 真人, 後藤 育子, 明石 昌也, 吉位 尚, 古森 孝英

    2006年2月〜2012年3月に歯科口腔外科を受診し6ヵ月以上経過観察したビスホスホネート関連顎骨壊死(BRONJ)症例33例(男性7例、女性26例)を対象に分析し、転帰に影響する因子について検討した。治療法については原因歯の抜歯、抜歯窩掻爬、腐骨分離前の腐骨除去、顎骨切除など外科的処置を行った症例を外科的処置群、保存的処置を行った症例を保存的処置群とした。転帰評価方法は2013年2月時点、症状が消失した症状消失、ステージが改善した症状改善、変わらない症状不変、悪化した症状悪化に分けた。患者背景は性別は女性に多く、年齢は平均70.3(53〜85)歳、部位別では上顎9例(27.3%)、下顎22例(66.7%)、上下顎2例(2%)で、下顎に発症した症例が多く、投与経路はBP経口剤が多かった。初診時のステージ分類は2010年のBRONJにおける分類でステージ0が9例、ステージ1が9例(各27.3%)、ステージ2が10例(30.3%)、ステージ3が5例(15.1%)であった。発症の誘因として抜歯による症例が多く占めていた。転帰については症状消失24例(72.7%)、症状改善1例(3%)、症状不変8例(24.2%)であった。転帰に影響する因子はBP注射剤による症例、BP製剤を休薬できなかった症例、全身的危険因子を有する難治例が多い傾向がみられた。

    (一社)日本口腔感染症学会, 2014年06月, 日本口腔感染症学会雑誌, 21 (1), 2 - 7, 日本語

  • 当科における重症歯性感染症例の臨床的検討

    藤林 淳子, 古土井 春吾, 小松原 秀紀, 楠元 順哉, 後藤 育子, 明石 昌也, 古森 孝英

    (一社)日本口腔感染症学会, 2014年06月, 日本口腔感染症学会雑誌, 21 (1), 49 - 49, 日本語

  • 過去15年間の高齢口腔癌患者に関する臨床的検討

    米澤 奈津季, 南川 勉, 高橋 佑輔, 明石 昌也, 渋谷 恭之, 古森 孝英

    (一社)日本頭頸部癌学会, 2014年05月, 頭頸部癌, 40 (2), 158 - 158, 日本語

  • 口腔癌再建術後の感染性合併症 術後CRPのabnormal responseに注目して

    明石 昌也, 橋川 和信, 南川 勉, 渋谷 恭之, 古森 孝英

    (一社)日本頭頸部癌学会, 2014年05月, 頭頸部癌, 40 (2), 182 - 182, 日本語

  • 放射線誘発癌が疑われた口腔癌に対する遊離皮弁再建

    明石 昌也, 橋川 和信, 寺師 浩人

    (一社)日本形成外科学会, 2014年03月, 日本形成外科学会会誌, 34 (3), 238 - 238, 日本語

  • 岩田 英治, 古土井 春吾, 楠元 順哉, 後藤 育子, 明石 昌也, 古森 孝英

    (NPO)日本口腔科学会, 2014年03月, 日本口腔科学会雑誌, 63 (2), 246 - 246, 日本語

  • 辻 和志, 渋谷 恭之, 明石 昌也, 古土井 春吾, 古森 孝英

    (NPO)日本口腔科学会, 2014年01月, 日本口腔科学会雑誌, 63 (1), 65 - 66, 日本語

  • 口腔癌cN1症例に対する頸部郭清術の郭清範囲についての検討

    筧康正, 南川勉, 高橋佑輔, 松井太輝, 長谷川巧実, 明石昌也, 重田崇至, 古土井春吾, 渋谷恭之, 古森孝英

    2014年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 32nd, 172, 日本語

  • 舌癌180例のリンパ節転移に関する検討~健側転移について~

    松井太輝, 重田崇至, 南川勉, 明石昌也, 高橋佑輔, 筧康正, 古土井春吾, 渋谷恭之, 古森孝英

    2013年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 31st, 140, 日本語

  • 口腔扁平上皮癌術後局所再発症例に関する検討

    高橋佑輔, 南川勉, 筧康正, 松井太輝, 榊原晶子, 明石昌也, 重田崇至, 渋谷恭之, 古森孝英

    2013年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 31st, 141, 日本語

  • 口腔扁平上皮癌T4症例に対する手術療法の治療成績

    筧康正, 南川勉, 高橋佑輔, 松井太輝, 榊原晶子, 明石昌也, 重田崇至, 古土井春吾, 渋谷恭之, 古森孝英

    2013年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 31st, 144, 日本語

  • プレート破折後に遊離腓骨皮弁で下顎骨再建を行った1例

    明石 昌也, 橋川 和信, 田原 真也

    (一社)日本形成外科学会, 2012年09月, 日本形成外科学会会誌, 32 (9), 711 - 712, 日本語

    [査読有り]

    会議報告等

  • 骨髄移植後GVHD患者に発生した口腔扁平上皮癌の2例

    筧康正, 南川勉, 松井太輝, 榊原晶子, 明石昌也, 三浦真香, 重田崇至, 小松原秀紀, 渋谷恭之, 古森孝英

    2012年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 30th, 211, 日本語

  • 口腔扁平上皮癌に対する頸部郭清術施行205例の頸部転移様相

    松井 太輝, 重田 崇至, 高橋 英哲, 高橋 佑輔, 明石 昌也, 南川 勉, 渋谷 恭之, 梅田 正博, 古森 孝英

    (公社)日本口腔外科学会, 2011年09月, 日本口腔外科学会雑誌, 57 (Suppl.), 99 - 99, 日本語

  • 口腔に発生した紡錘細胞癌における肺転移巣の倍加時間について

    重田 崇至, 南川 勉, 小松原 秀紀, 榊原 晶子, 明石 昌也, 高橋 英哲, 松井 太輝, 渋谷 恭之, 梅田 正博, 古森 孝英

    (公社)日本口腔外科学会, 2011年09月, 日本口腔外科学会雑誌, 57 (Suppl.), 191 - 191, 日本語

  • 顎口腔再建におけるフェーズコントラスト型CT Angiographyの有用性について

    明石 昌也, 橋川 和信, 南川 勉, 重田 崇至, 榊原 晶子, 古土井 春吾, 渋谷 恭之, 古森 孝英

    (公社)日本口腔外科学会, 2011年09月, 日本口腔外科学会雑誌, 57 (Suppl.), 215 - 215, 日本語

  • 舌癌のstage I・II症例における臨床的検討について

    西村 裕貴, 重田 崇至, 高橋 佑輔, 松井 太輝, 高橋 英哲, 榊原 晶子, 明石 昌也, 南川 勉, 渋谷 恭之, 梅田 正博, 古森 孝英

    (公社)日本口腔外科学会, 2011年09月, 日本口腔外科学会雑誌, 57 (Suppl.), 324 - 324, 日本語

  • 当科における口底扁平上皮癌手術症例の臨床病理学的検討

    筧 康正, 南川 勉, 松井 太輝, 高橋 英哲, 榊原 晶子, 明石 昌也, 重田 崇至, 渋谷 恭之, 梅田 正博, 古森 孝英

    (公社)日本口腔外科学会, 2011年09月, 日本口腔外科学会雑誌, 57 (Suppl.), 200 - 200, 日本語

  • 口腔癌手術における嚥下改善手術に関する臨床的検討

    明石 昌也, 南川 勉, 高橋 英哲, 小國 晶子, 橋川 和信, 古土井 春吾, 渋谷 恭之, 梅田 正博, 古森 孝英

    (公社)日本口腔外科学会, 2010年09月, 日本口腔外科学会雑誌, 56 (Suppl.), 140 - 140, 日本語

  • 外側舌リンパ節転移を認めた口底癌の1例

    木本 明, 南川 勉, 小林 正樹, 服部 真季, 明石 昌也, 澁谷 恭之, 横尾 聡, 梅田 正博, 古森 孝英

    (公社)日本口腔外科学会, 2007年06月, 日本口腔外科学会雑誌, 53 (6), 400 - 400, 日本語

  • 顎関節症患者の臨床統計的検討

    渋谷 恭之, 竹内 純一郎, 池端 伯子, 藤田 剛史, 明石 昌也, 古森 孝英

    (一社)日本顎関節学会, 2006年04月, 日本顎関節学会雑誌, 18 (1), 48 - 48, 日本語

  • 当科における顎関節症III a患者の臨床統計的検討

    竹内 純一郎, 渋谷 恭之, 池端 伯子, 藤田 剛史, 明石 昌也, 古森 孝英

    (一社)日本顎関節学会, 2006年04月, 日本顎関節学会雑誌, 18 (1), 48 - 48, 日本語

  • 当科における顎関節症I・II患者の臨床統計的検討

    池端 伯子, 渋谷 恭之, 竹内 純一郎, 明石 昌也, 藤田 剛史, 古森 孝英

    (一社)日本顎関節学会, 2006年04月, 日本顎関節学会雑誌, 18 (1), 80 - 80, 日本語

  • 当科における顎関節症III b型患者の臨床統計的検討

    藤田 剛史, 渋谷 恭之, 竹内 純一郎, 池端 伯子, 明石 昌也, 古森 孝英

    (一社)日本顎関節学会, 2006年04月, 日本顎関節学会雑誌, 18 (1), 80 - 81, 日本語

  • 当科における顎関節症IV型患者の臨床統計的検討

    明石 昌也, 渋谷 恭之, 竹内 純一郎, 池端 伯子, 藤田 剛史, 古森 孝英

    (一社)日本顎関節学会, 2006年04月, 日本顎関節学会雑誌, 18 (1), 81 - 81, 日本語

  • Clinical investigation of vascular malformations of the oral region treated by multiple photocoagulation with an Nd:YAG laser

    Matsumoto Kousuke, Ono Masataka, Kitayama Midori, Akashi Masaya, Suzuki Hiroaki, Komori Takahide

    Japanese Stomatological Society, 2015年, Oral science in Japan, 63 - 65, 英語

  • Clinical analysis of the chronological change in bone mass following sinus floor elevation

    Suzuki Hiroaki, Matsumoto Kousuke, Enomoto Yui, Kakei Yasumasa, Kimoto Akira, Akashi Masaya, Komori Takahide

    Japanese Stomatological Society, 2015年, Oral science in Japan, 79 - 82, 英語

  • Targeted Disruption of JCAD/KIAA1462, a Coronary Artery Disease-associated Gene Product, Inhibits Angiogenic Processes in Vitro and in Vivo

    Tetsuya Hara, Tomoko Monguchi, Masaya Akashi, Noriko Iwamoto, Kenta Mori, Ryuji Toh, Yasuhiro Irino, Masakazu Shinohara, Mikio Furuse, Tatsuro Ishida, Ken-ichi Hirata

    LIPPINCOTT WILLIAMS & WILKINS, 2015年11月, CIRCULATION, 132, 英語

    研究発表ペーパー・要旨(国際会議)

書籍等出版物

  • 改訂版日常の口腔外科 病診連携1SMART&SMOOTH / V-7 顎関節疾患治療の概要を知る

    古森孝英, 横尾聡, 古土井春吾, 綿谷早苗, 梅田正博, 渋谷恭之, 藤岡学, 立石千鶴, 南川勉, 松本耕祐, 榊原晶子, 鈴木泰明, 明石昌也

    その他, 永末書店, 2018年, 日本語

    教科書・概説・概論

  • Oral and Craniofacial Diseases and Disorders / Capter 2: Complications Following Radiation Therapy for Head and Neck Malignancy

    AkashiM, KomoriT, MinamikawaT, HasegawaT, NishiiM, HashikawaK, SeddikMH, SasakiR

    その他, Oxford University Press, 2018年, 英語

    学術書

  • OPEN ACCESS e Books: Oral and Craniofacial Disease and Disorders. / Oral complications following radiation theraphy for head anad neck malignancy

    AkashiM, KomoriT, MinamikawaT, HasegawaT, NishiiM, HashikawaH, SeddikMH, SasakiR

    その他, -, 2018年, 英語

    学術書

  • 新こんな患者さんが歯科に来たときは?全身疾患・口腔外科疾患に対する診療マニュアル / 味覚障害への対応

    明石昌也, 鄒天皓

    その他, 第一歯科出版, 2014年, 日本語

    一般書・啓蒙書

  • 新こんな患者さんが歯科に来たときは?全身疾患・口腔外科疾患に対する診療マニュアル / 腎障害患者への対応

    明石昌也, 大槻有美, 若林玲奈, 高橋英哲

    その他, 第一歯科出版, 2014年, 日本語

    一般書・啓蒙書

  • 新こんな患者さんが歯科に来たときは?全身疾患・口腔外科疾患に対する診療マニュアル / 三叉神経痛への対応

    明石昌也, 藤原健一, 高田直樹

    その他, 第一歯科出版, 2014年, 日本語

    一般書・啓蒙書

講演・口頭発表等

  • 心血管外科手術周術期の口腔機能管理に関する臨床的検討

    難波渚, 明石昌也, 古森孝英, 桶本翔吾, 小槇 公大, 小川 真人, 坪井 康典, 小林 成美, 後竹 康子, 大北裕

    第3回日本心臓リハビリテーション学会近畿地方会, 2018年02月, 日本語, 日本心臓リハビリテーション学会, 神戸, 国内会議

    口頭発表(一般)

  • 下顎骨壊死における下歯槽神経障害の臨床病理学的検討

    平岡佑二郎, 明石昌也, 重岡学, 楠元順哉, 長谷川巧実, 古森孝英

    第62回日本口腔外科学会総会・学術大会, 2017年10月, 日本語, 京都, 国内会議

    口頭発表(一般)

  • FDG PET-CTは重症下顎放射線性顎骨壊死の切除範囲決定に有用か?.

    明石昌也, 橋川和信, 楠元順哉, 古土井春吾, 古森孝英

    第62回日本口腔外科学会総会・学術大会(京都), 2017年10月, 日本語, 日本口腔外科学会, 京都, 国内会議

    シンポジウム・ワークショップパネル(公募)

  • 神経症状を伴った下顎放射線性顎骨壊死における下歯槽神経の病理組織学的研究.

    明石昌也, 楠元順哉, 長谷川巧実, 南川勉, 橋川和信, 古森孝英

    第41回日本頭頸部癌学会(京都), 2017年06月, 日本語, 日本頭頸部癌学会, 京都, 国内会議

    口頭発表(一般)

  • 【シンポジウム2「頭頸部再建に残された課題-二次再建の挑戦と課題-」】重症下顎骨放射線骨髄炎に対する手術―デブリドマン範囲を病理組織学的検討結果から考察する―.

    橋川和信, 明石昌也, 楠元順哉, 野村正, 寺師浩人

    第60回日本形成外科学会総会・学術集会(大阪), 2017年04月, 日本語, 日本形成外科学会, 大阪, 国内会議

    シンポジウム・ワークショップパネル(公募)

  • 4DCT EVALUATION OF CONDYLAR MOVEMEN IN PATIENTS UNDERWENT MANDIBULAR RECONSTRUCTION.

    Masaya Akashi, Toshinori Sekitani, Yumi Ohtsuki, Yasumasa Kakei, Takumi Hasegawa, Noriyuki Negi, Kazunobu Hashikawa, Yasuyuki Shibuya, Satoru Takahashi, Takahide Komori

    23nd International Conference on Oral and Maxillofacial Surgery(Hong Kong), 2017年03月, 日本語, International Conference on Oral and Maxillofacial Surgery, Hong Kong, 海外, 国内会議

    口頭発表(一般)

  • 口腔扁平上皮癌では外的刺激受容体(TRPVチャネル)の発現が亢進する.

    榊原晶子, 榊原俊介, 楠元順哉, 武田大介, 長谷川巧実, 明石昌也, 南川勉, 橋川和信, 古森孝英

    第35回口腔腫瘍学会(福岡), 2017年01月, 日本語, 口腔腫瘍学会, 福岡, 国内会議

    口頭発表(一般)

  • 内視鏡支援下で上顎洞迷入インプラントの摘出後に骨造成術を行った1例

    山下淳也, 鈴木 泰明, 筧康正, 木本 明, 長谷川巧実, 明石昌也, 古森孝英

    第20回日本顎顔面インプラント学会, 2016年12月, 日本語, 日本顎顔面インプラント学会, 東京, 国内会議

    ポスター発表

  • 当科におけるインプラント埋入症例と喪失リスクに関する臨床的検討

    片岡侑嗣, 長谷川巧実, 綿越健太, 浅井雅敏, 有本智美, 明石昌也, 鈴木 泰明, 古森孝英

    第20回日本顎顔面インプラント学会, 2016年12月, 日本語, 日本顎顔面インプラント学会, 東京, 国内会議

    ポスター発表

  • チタンミニプレートと固定用スクリューの関与が疑われた乾癬様皮疹の1例

    可信雅彦, 明石昌也, 古土井春吾, 古森孝英

    第28回口腔科学会近畿地方部会, 2016年12月, 日本語, 日本口腔科学会, 大阪, 国内会議

    口頭発表(一般)

  • 腓骨皮弁による下顎再建におけるミニプレートと再建用プレートの比較

    平岡佑二郎, 明石昌也, 筧 康正, 楠元順哉, 榊原晶子, 長谷川巧実, 南川 勉, 橋川和信, 古森孝英

    第61回日本口腔外科学会総会・学術大会, 2016年11月, 日本語, 日本口腔外科学会, 千葉, 国内会議

    口頭発表(一般)

  • 放射線性顎骨壊死の病理組織学的検討

    鰐渕 聡, 明石昌也, 岩田英治, 筧 康正, 楠元順哉, 南川 勉, 古土井春吾, 橋川和信, 古森孝英

    第61回日本口腔外科学会総会・学術大会, 2016年11月, 日本語, 日本口腔外科学会, 千葉, 国内会議

    口頭発表(一般)

  • 頭頸部領域の蜂窩識炎に対する好中球/リンパ球比,血小板/リンパ球比の有用性の検討

    楠元順哉, 古土井春吾, 岸本惠実, 岩田英治, 明石昌也, 古森孝英

    第61回日本口腔外科学会総会・学術大会, 2016年11月, 日本語, 日本口腔外科学会, 千葉, 国内会議

    口頭発表(一般)

  • 頭頸部蜂窩織炎に対する好中球/リンパ球比,血小板/リンパ球比の有用性の検討

    楠元 順哉, 古土井 春吾, 岸本 恵実, 岩田 英治, 藤林 淳子, 明石 昌也, 古森 孝英

    第61回公益社団法人日本口腔外科学会総会・学術大会, 2016年11月, 日本語, 公益社団法人日本口腔外科学会総会・学術大会, 千葉市, 国内会議

    口頭発表(一般)

  • 当科における舌癌・口底癌手術症例の再建方法に関する検討

    綿越健太, 南川 勉, 米澤奈津季, 筧 康正, 長谷川巧実, 榊原晶子, 明石昌也, 古土井春吾, 古森孝英

    第61回日本口腔外科学会総会・学術大会, 2016年11月, 日本語, 日本口腔外科学会, 千葉, 国内会議

    ポスター発表

  • 当科における心臓血管外科開胸手術患者に対する周術期口腔機能管理の臨床的検討

    難波 渚, 明石昌也, 西井美佳, 楠元順哉, 松本耕祐, 長谷川巧実, 古土井春吾, 古森孝英

    第61回日本口腔外科学会総会・学術大会, 2016年11月, 日本語, 日本口腔外科学会, 千葉, 国内会議

    口頭発表(一般)

  • 当科における口腔癌患者の口腔内細菌数の変化とSSIについて

    小守紗也華, 長谷川巧実, 西井美佳, 明石昌也, 古土井春吾, 古森孝英

    第61回日本口腔外科学会総会・学術大会, 2016年11月, 日本語, 日本口腔外科学会, 千葉, 国内会議

    口頭発表(一般)

  • 造血器悪性腫瘍患者に対する化学療法中の歯性感染症が原因の敗血症発症率

    岸本惠実, 明石昌也, 辻 和志, 楠元順哉, 古土井春吾, 古森孝英

    第61回日本口腔外科学会総会・学術大会, 2016年11月, 日本語, 日本口腔外科学会, 千葉, 国内会議

    口頭発表(一般)

  • 舌癌切除後の前腕皮弁再建における 切除検体サイズと皮弁サイズの 相関と機能の検討

    榊原 晶子, 楠元 順哉, 長谷川 巧実, 明石 昌也, 南川 勉, 古土井 春吾, 橋川 和信, 古森 孝英

    第61回公益社団法人日本口腔外科学会総会・学術大会, 2016年11月, 日本語, 公益社団法人日本口腔外科学会総会・学術大会, 千葉市, 国内会議

    口頭発表(一般)

  • 舌癌切除後の前腕皮弁再建における切除検体サイズと皮弁サイズの僧冠と機能の検討

    榊原晶子, 楠元順哉, 長谷川巧実, 明石昌也, 南川勉, 古土井春吾, 橋川和信, 古森孝英

    第61回日本口腔外科学会総会・学術大会, 2016年11月, 日本語, 日本口腔外科学会, 千葉, 国内会議

    口頭発表(一般)

  • 口腔癌放射線治療における有効な新規併用療法の探索

    岩田英治, 長谷川巧実, 武田大介, 斉藤 泉, 有本智美, 明石昌也, 南川 勉, 古森孝英

    第61回日本口腔外科学会総会・学術大会, 2016年11月, 日本語, 日本口腔外科学会, 千葉, 国内会議

    ポスター発表

  • 口腔癌術後リンパ浮腫に関するCT解析

    寺岡 駿, 明石昌也, 筧 康正, 楠元順哉, 榊原晶子, 長谷川巧実, 南川 勉, 橋川和信, 古森孝英

    第61回日本口腔外科学会総会・学術大会, 2016年11月, 日本語, 日本口腔外科学会, 千葉, 国内会議

    口頭発表(一般)

  • 局所的炭酸ガス投与による皮弁壊死抑制効果

    齊藤 泉, 長谷川巧実, 武田大介, 岩田英治, 有本智美, 榊原晶子, 明石昌也, 南川勉, 古森孝英

    第61回日本口腔外科学会総会・学術大会, 2016年11月, 日本語, 日本口腔外科学会, 千葉, 国内会議

    ポスター発表

  • 下顎枝垂直骨切り術後の骨癒合に対する低出力超音波パルス(LIPUS)の効果

    有本智美, 長谷川巧実, 齊藤 泉, 岩田英治, 武田大介, 立石千鶴, 明石昌也, 鈴木泰明, 古土井春吾, 古森孝英

    第61回日本口腔外科学会総会・学術大会, 2016年11月, 日本語, 日本口腔外科学会, 千葉, 国内会議

    ポスター発表

  • 遠位レベル(Level IV,V)への頸部リンパ節転移を生じた口腔扁平上皮癌患者の予後に関する後ろ向き観察研究

    長谷川巧実, 南川 勉, 米澤奈津季, 高橋佑輔, 筧 康正, 榊原晶子, 明石昌也, 古森孝英

    第61回日本口腔外科学会総会・学術大会, 2016年11月, 日本語, 日本口腔外科学会, 千葉, 国内会議

    口頭発表(一般)

  • 口腔癌術後に消化管穿孔を発症した1例

    高橋淳子, 古土井春吾, 岸本恵美, 岩田英治, 楠元順哉, 梶 真人, 後藤育子, 明石昌也, 古森孝英

    第25回日本口腔感染症学会総会・学術大会, 2016年10月, 日本語, 日本口腔感染症学会, 神戸, 国内会議

    口頭発表(一般)

  • 結節性硬化症患者に対する口腔衛生管理の現状ーエベロリムスによる口内炎への対応ー

    西井美佳, 古土井春吾, 岸本惠実, 岩田英治, 楠元順哉, 明石昌也, 古森孝英

    第25回日本口腔感染症学会総会・学術大会, 2016年10月, 日本語, 日本口腔感染症学会, 神戸, 国内会議

    口頭発表(一般)

  • スニチニブに関連して発症したと考えられる下顎骨壊死の1例

    岩田英治, 古土井春吾, 岸本惠実, 高橋淳子, 楠元順哉, 後藤育子, 明石昌也, 古森孝英

    第25回日本口腔感染症学会総会・学術大会, 2016年10月, 日本語, 日本口腔感染症学会, 神戸, 国内会議

    口頭発表(一般)

  • Development of the new treatment of OSCC by local application of transcutaneous carbon dioxide

    Iwata E, Hasegawa T, Takeda D, Saito I, Arimoto S, Akashi M, Minamikawa T, Komori T

    The 23rd European Association for Cranio Maxillo-Facial Surgery (EACMFS), 2016年09月, 日本語, UKレーザー歯学会, London, UK, 国際会議

    ポスター発表

  • Determination of resection margins by using a combination of CT, MRI, PET, and 3D model in osteoradionecrosis of the jaw

    Masaya Akashi, Kazunobu Hashikawa, Satoshi Wanifuchi, Megumi Kishimoto, Eiji Iwata, Yasumasa Kakei, Junya Kusumoto, Kousuke Matsumoto, Akiko Sakakibara, Takumi Hasegawa, Tsutomu Minamikawa, Shungo Furudoi, Takahide Komori

    The 23th Congress of EACMFS, 2016年09月, 英語, Congress of EACMFS, London, イギリス, 国際会議

    口頭発表(一般)

  • Determination of resection margins by using a combination of CT, MRI, PET, and 3D model in osteoradionecrosis of the jaw

    Akashi M, Hashikawa K, Wanifuchi S, Kishimoto M, Iwata E, Kakei Y, Kusumoto J, Matsumoto K, Sakakibara A, Hasegawa T, Minamikawa T, Furudoi S, Komori T

    The 23rd European Association for Cranio Maxillo-Facial Surgery (EACMFS), 2016年09月, 日本語, UKレーザー歯学会, London, UK, 国際会議

    ポスター発表

  • Changes of cell junctions induced by EGFR inhibition in oral squamous cell carcinomas

    Kakei Y, Akashi M, Teraoka S, Hasegawa T, Komori T

    The 23rd European Association for Cranio Maxillo-Facial Surgery (EACMFS), 2016年09月, 日本語, UKレーザー歯学会, London, UK, 国際会議

    ポスター発表

  • A clinical study of injured patients treated with dental implants

    Suzuki H, Takeuchi J, Matsuo K, Kakei Y, Kimoto A, Hasegawa T, Akashi M, Chikazu D, Komori T

    The 23rd European Association for Cranio Maxillo-Facial Surgery (EACMFS), 2016年09月, 日本語, UKレーザー歯学会, London, UK, 国際会議

    ポスター発表

  • A clinical study of 12 implants resulting in implant removal

    Takahashi D, Suzuki H, Kakei Y, Hasegawa T, Akashi M, Minamikawa T, Takahide Komori

    The 23rd European Association for Cranio Maxillo-Facial Surgery (EACMFS),, 2016年09月, 日本語, UKレーザー歯学会, London, UK, 国際会議

    ポスター発表

  • 頬部に認めた孤立性線維性腫瘍の1例

    鰐渕 聡, 大槻有美, 後藤育子, 明石昌也, 鈴木泰明, 南川 勉, 古土井春吾, 古森孝英

    第47回日本口腔外科学会近畿支部学術集会, 2016年07月, 日本語, 日本口腔外科学会, 大阪, 国内会議

    口頭発表(一般)

  • 脳神経外科術後の顎関節症の臨床的検討

    大槻有美, 明石昌也, 黄文蘇, 筧康正, 古森孝英

    第29回日本顎関節学会総会・学術大会, 2016年07月, 日本語, 日本顎関節学会, 箱根, 国内会議

    口頭発表(一般)

  • 当科における心臓血管外科周術期の口腔機能管理に関する実態と今後の課題

    難波 渚, 明石昌也, 冨田 和, 田村恵利, 澤田麻衣子, 西井美佳, 長谷川巧実, 古土井春吾, 古森孝英

    第32回兵庫県歯科医学大会, 2016年07月, 日本語, 兵庫県歯科医師会, 神戸, 国内会議

    口頭発表(一般)

  • 当科における顎関節脱臼の臨床的検討

    大槻有美, 明石昌也, 黄文蘇, 筧康正, 古森孝英

    第29回日本顎関節学会総会・学術大会, 2016年07月, 日本語, 日本顎関節学会, 箱根, 国内会議

    ポスター発表

  • 当院における過去8年間の外傷歯患者の臨床統計的検討 ~顎骨骨折の有無と外傷歯の関係について~

    可信雅彦, 筧 康正, 小守紗也華, 明石昌也, 古土井春吾, 古森孝英

    第16回日本外傷歯学会総会・学術大会, 2016年07月, 日本語, 日本外傷歯学会, 神戸, 国内会議

    口頭発表(一般)

  • 造血器悪性腫瘍に対する化学療法中のD-indexと口腔内感染性合併症との関連についての検討

    明石 昌也, 岸本 恵実, 辻 和志, 楠元 順哉, 薬師神 公和, 川本 晋一郎, 岡村 篤夫, 松岡 広, 古土井 春吾, 古森 孝英

    第14回日本臨床腫瘍学会, 2016年07月, 日本語, 日本臨床腫瘍学会, 神戸市, 国内会議

    口頭発表(一般)

  • 全身麻酔挿管中に生じる歯の損傷も後ろ向き調査

    小守紗也華, 筧 康正, 可信雅彦, 明石昌也, 古土井春吾, 古森孝英

    第16回日本外傷歯学会総会・学術大会, 2016年07月, 日本語, 日本外傷歯学会, 神戸, 国内会議

    口頭発表(一般)

  • 顎関節に生じた滑膜骨軟骨腫症の1例

    黄文蘇, 明石昌也, 大槻有美, 橘進彰, 古森孝英

    第29回日本顎関節学会総会・学術大会, 2016年07月, 日本語, 日本顎関節学会, 箱根, 国内会議

    ポスター発表

  • 下顎歯肉癌の精査においてCowden症候群の合併が示唆された1例

    榎本由依, 明石昌也, 平岡佑二郎, 船原隆一郎, 南川 勉, 古森孝英

    第47回日本口腔外科学会近畿支部学術集会, 2016年07月, 日本語, 日本口腔外科学会, 大阪, 国内会議

    口頭発表(一般)

  • 下顎骨骨折の治療を行ったLennox-Gastaut症候群患児の1例

    中西洋介, 松本耕祐, 小守紗也華, 長谷川巧実, 明石昌也, 柚鳥宏和, 橘進彰, 古森孝英

    第16回日本外傷歯学会総会・学術大会, 2016年07月, 日本語, 日本外傷歯学会, 神戸, 国内会議

    口頭発表(一般)

  • 15歳女児に生じた舌扁平上皮癌の1例

    綿越健太, 南川勉, 寺岡 駿, 明石昌也, 古森孝英

    第47回日本口腔外科学会近畿支部学術集会, 2016年07月, 日本語, 日本口腔外科学会, 大阪, 国内会議

    口頭発表(一般)

  • 歯科インプラント埋入のためのデンタルCTを用いた移植腓骨の形態評価

    明石昌也, 橋川和信, 鰐渕 聡, 楠元順哉, 長谷川巧実, 南川 勉, 寺師浩人, 古森孝英

    第40回日本頭頸部癌学会総会・学術大会, 2016年06月, 日本語, 日本頭頸部癌学会, 埼玉, 国内会議

    口頭発表(一般)

  • 歯科インプラント埋入のためのデンタルCTを用いた移植腓骨の形態評価

    明石 昌也, 橋川 和信, 鰐渕聡, 楠元 順哉, 長谷川巧実, 南川勉, 寺師 浩人, 古森 孝英

    第40回日本頭頸部癌学会, 2016年06月, 日本語, 日本頭頸部癌学会, さいたま市, 国内会議

    口頭発表(一般)

  • 下顎枝垂直骨切り術後の骨癒合に対する低出力超音波パルス(LIPUS)の効果

    有本智美, 長谷川巧実, 岡本奈那, 塩屋園敦, 立石千鶴, 明石昌也, 鈴木泰明, 古土井春吾, 古森孝英

    第26回日本顎変形症学会総会・学術大会, 2016年06月, 日本語, 日本顎変形症学会, 東京, 国内会議

    ポスター発表

  • 4D-CTによる下顎再建術後患者の咀嚼の観察

    明石昌也, 橋川和信, 渋谷恭之, 寺師浩人, 古森孝英

    第40回日本頭頸部癌学会総会・学術大会, 2016年06月, 日本語, 日本頭頸部癌学会, 埼玉, 国内会議

    口頭発表(一般)

  • 4D-CTによる下顎再建術後患者の咀嚼の観察

    明石 昌也, 橋川 和信, 渋谷恭之, 寺師 浩人, 古森 孝英

    第40回日本頭頸部癌学会, 2016年06月, 日本語, 日本頭頸部癌学会, さいたま市, 国内会議

    口頭発表(一般)

  • 放射線性顎骨鋭氏壊死症例に対する画像診断を中心とした臨床的検討

    鰐渕 聡, 明石昌也, 岩田英治, 楠元順哉, 松本耕佑, 南川 勉, 古土井春吾, 古森孝英

    第70回日本口腔科学会総会・学術大会, 2016年04月, 日本語, 日本口腔科学会, 福岡, 国内会議

    口頭発表(一般)

  • 当科における埋伏智歯抜歯後神経系合併症に対する治療法の現状

    平岡佑二郎, 明石昌也, 松本耕祐, 榊原晶子, 木本 明, 長谷川巧実, 鈴木泰明, 南川勉, 古土井春吾, 古森孝英

    第70回日本口腔科学会総会・学術大会, 2016年04月, 日本語, 日本口腔科学会, 福岡, 国内会議

    口頭発表(一般)

  • 当科における歯性上顎洞炎の臨床的検討

    岩田英治, 明石昌也, 岸本恵実, 藤林淳子, 楠元順哉, 古土井春吾, 古森孝英

    第70回日本口腔科学会総会・学術大会, 2016年04月, 日本語, 日本口腔科学会, 福岡, 国内会議

    ポスター発表

  • 当科におけるFibro-osseous lesionsの臨床的検討

    松尾健司, 明石昌也, 筧 康正, 松本耕祐, 長谷川巧実, 南川 勉, 古土井春吾, 橘進彰, 古森孝英

    第70回日本口腔科学会総会・学術大会, 2016年04月, 日本語, 日本口腔科学会, 福岡, 国内会議

    口頭発表(一般)

  • 中咽頭癌化学放射線治療患者における口腔衛生管理-強度変調放射線治療(IMRT)と従来型放射線治療(RT)の比較

    西井美佳, 筧 康正, 冨田 和, 難波 渚, 田村恵利, 澤田麻衣子, 明石昌也, 古土井春吾, 古森孝英

    第13回日本口腔ケア学会総会・学術大会, 2016年04月, 日本語, 日本口腔ケア学会, 千葉, 国内会議

    口頭発表(一般)

  • 遺伝子解析により確定診断を得たMALTリンパ腫の1例

    筧 康正, 明石昌也, 木本 明, 長谷川巧実, 南川 勉, 古森孝英

    第70回日本口腔科学会総会・学術大会, 2016年04月, 日本語, 日本口腔科学会, 福岡, 国内会議

    口頭発表(一般)

  • 腓骨皮弁採取部における一期縫縮と植皮の比較

    渡邊一博, 明石昌也, 楠本順哉, 松本耕祐, 木本 明, 榊原晶子, 長谷川巧実, 南川勉, 橋川和信, 古森孝英

    第34回日本口腔腫瘍学会総会・学術大会, 2016年01月, 日本語, 日本口腔腫瘍学会, 横浜, 国内会議

    ポスター発表

  • 術前18F-FDG PET/CT撮影での口腔癌原発巣における定量評価の有用性

    米澤奈津季, 南川 勉, 北島一宏, 高橋佑輔, 筧 康正, 榊原晶子, 長谷川巧実, 明石昌也, 古森孝英

    第34回日本口腔腫瘍学会総会・学術大会, 2016年01月, 日本語, 日本口腔腫瘍学会, 横浜, 国内会議

    ポスター発表

  • 口腔扁平上皮癌被膜外浸潤症例の臨床病理学的検討

    筧 康正, 南川 勉, 寺岡 駿, 米澤奈津季, 高橋佑輔, 長谷川巧実, 明石昌也, 古森孝英

    第34回日本口腔腫瘍学会総会・学術大会, 2016年01月, 日本語, 日本口腔腫瘍学会, 横浜, 国内会議

    ポスター発表

  • 口腔扁平上皮癌患者の遠位レベル(level4,5)への頸部リンパ節転移が予後に与える影響

    定兼啓倫, 長谷川巧実, 渋谷恭之, 米澤奈津季, 武田大介, 高橋佑輔, 筧 康正, 明石昌也, 南川 勉, 古土井春吾, 橋川和信, 古森孝英

    第34回日本口腔腫瘍学会総会・学術大会, 2016年01月, 日本語, 日本口腔腫瘍学会, 横浜, 国内会議

    ポスター発表

  • 口腔扁平上皮癌における外的刺激受容体(TRPVチャネル)の発現

    榊原 晶子, 榊原 俊介, 楠元 順哉, 武田 大介, 長谷川 巧実, 明石 昌也, 南川 勉, 橋川 和信, 古森 孝英

    第34回日本口腔腫瘍学会総会・学術大会, 2016年01月, 日本語, 日本口腔腫瘍学会総会・学術大会, 横浜市, 国内会議

    口頭発表(一般)

  • 口腔扁平上皮癌における外的刺激受容体(TRPVチャネル)の発現亢進

    榊原晶子, 榊原俊介, 楠元順哉, 武田大介, 長谷川巧実, 明石昌也, 南川 勉, 橋川和信, 古森孝英

    第34回日本口腔腫瘍学会総会・学術大会, 2016年01月, 日本語, 日本口腔腫瘍学会, 横浜, 国内会議

    ポスター発表

  • 局所的炭酸ガス投与による皮弁壊死抑制効果

    齊藤 泉, 長谷川巧実, 武田大介, 岩田英治, 有本智美, 筧康正, 高橋佑輔, 榊原晶子, 明石昌也, 南川勉, 古森孝英

    第34回日本口腔腫瘍学会総会・学術大会, 2016年01月, 日本語, 日本口腔腫瘍学会, 横浜, 国内会議

    ポスター発表

  • 移植腓骨と下顎骨の癒合における骨膜温存の重要性(ポスター発表)

    明石昌也, 筧 康正, 榊原晶子, 長谷川巧実, 南川 勉, 橋川和信, 古森孝英

    第34回日本口腔腫瘍学会総会・学術大会, 2016年01月, 日本語, 日本口腔腫瘍学会, 横浜, 国内会議

    ポスター発表

  • 移植腓骨と下顎骨の癒合における骨膜温存の重要性

    明石 昌也, 筧 康正, 榊原 晶子, 長谷川 巧実, 南川 勉, 橋川 和信, 古森 孝英

    第34回日本口腔腫瘍学会総会・学術大会, 2016年01月, 日本語, 日本口腔腫瘍学会総会・学術大会, 横浜市, 国内会議

    口頭発表(一般)

  • 再建プレート露出に対する二期再建術前PET/CTが膿瘍の検知に有用であった1例

    松尾 健司, 明石 昌也, 楠元 順哉, 藤林 淳子, 渡邊 一博, 南川 勉, 橋川 和信, 古森 孝英

    第27回NPO法人日本口腔科学会近畿地方部会., 2015年11月, 日本語, 日本口腔外科学会, 大阪, 国内会議

    口頭発表(一般)

  • 化学放射線療法による口腔粘膜炎の重症度を予測する因子についての検討

    岸本 恵実, 古土井 春吾, 藤林 淳子, 西井 美佳, 岩田 英治, 楠元 順哉, 梶 真人, 後藤 育子, 明石 昌也, 古森 孝英

    第24回日本口腔感染症学会総会., 2015年11月, 日本語, 日本口腔感染症学会, 神奈川, 国内会議

    口頭発表(一般)

  • Targeted Disruption of JCAD/KIAA1462, a Coronary Artery Disease-associated Gene Product, Inhibits Angiogenic Processes in Vitro and in Vivo.

    Tetsuya Hara, Tomoko Monguchi, Masaya Akashi, Noriko Iwamoto, Kenta Mori, Ryuji Toh, Yasuhiro Irino, Masakazu Shinohara, Mikio Furuse, Tatsuro Ishida, Ken-ichi Hirata

    American Heart Association Scientic Session 2015., 2015年11月, 英語, American Heart Association, Orlando, USA, Background: Recent genome-wide association studies newly identified the human KIAA1462 gene as a new locus for coronary artery disease. However, the function of the gene product, named JCAD (junctional protein associated with coronary artery disease), is unknown. Because JCAD is expressed at cell-cell junctions in endothelial cells, we hypothesized and tested whether JCAD regul, 国際会議

    ポスター発表

  • 入院管理下で口腔外科小手術を施行した患者に関する臨床統計

    棚倉 万紀子, 筧 康正, 南川 勉, 高橋 佑輔, 米澤 奈津季, 榊原 晶子, 長谷川 巧実, 明石 昌也, 古森 孝英

    第60回日本口腔外科学会総会, 2015年10月, 日本語, 日本口腔外科学会, 名古屋, 国内会議

    口頭発表(一般)

  • 超音波断層法による口腔癌頸部リンパ節転移の検討

    筧 康正, 南川 勉, 棚倉 万紀子, 米澤 奈津季, 高橋 佑輔, 松井 太輝, 長谷川 巧実, 明石 昌也, 重田 崇至, 古森 孝英

    第60回日本口腔外科学会総会, 2015年10月, 日本語, 日本口腔外科学会, 名古屋, 国内会議

    口頭発表(一般)

  • 進展例の放射線性顎骨壊死の外科的治療におけるPETの有用性.

    明石 昌也, 橋川 和信, 南川 勉, 古土井 春吾, 古森 孝英

    第60回日本口腔外科学会総会., 2015年10月, 日本語, 日本口腔外科学会, 名古屋, 国内会議

    口頭発表(一般)

  • 三次元実態模型を用いた手術シミュレーションー当科における最近の使用経験

    鰐渕 聡, 明石 昌也, 橋川和信, 筧 康正, 松本 耕祐, 木本 明, 長谷川 巧実, 南川 勉, 古土井 春吾, 古森 孝英

    第60回日本口腔外科学会総会, 2015年10月, 日本語, 日本口腔外科学会, 名古屋, 国内会議

    口頭発表(一般)

  • 口腔扁平上皮癌における外的刺激受容体の発現

    榊原 晶子, 楠元 順哉, 明石 昌也, 南川 勉, 古森 孝英

    第60回日本口腔外科学会, 2015年10月, 日本語, 日本口腔外科学会, 名古屋, 国内会議

    口頭発表(一般)

  • 口腔癌原発巣の術前18F-FDG PET/CT撮影に関する検討

    米澤 奈津季, 南川 勉, 北島一宏, 高橋 佑輔, 筧 康正, 榊原 晶子, 長谷川 巧実, 明石 昌也, 古森 孝英

    第60回日本口腔外科学会総会, 2015年10月, 日本語, 日本口腔外科学会, 名古屋, 国内会議

    口頭発表(一般)

  • 経皮的炭酸ガス投与による口腔癌上皮間葉移行の抑制効果

    岩田 英治, 長谷川 巧実, 武田 大介, 明石 昌也, 南川 勉, 古森 孝英

    第60回日本口腔外科学会総会, 2015年10月, 日本語, 日本口腔外科学会, 名古屋, 国内会議

    口頭発表(一般)

  • ロケーター・マグネット付きカスタムバーによるインプラントオーバーデンチャー関連合併症

    有本 智美, 長谷川 巧実, 斉藤 泉, 岩田 英治, 武田 大介, 明石 昌也, 鈴木 泰明, 古土井 春吾, 古森 孝英

    第60回日本口腔外科学会総会., 2015年10月, 日本語, 日本口腔外科学会, 名古屋, 国内会議

    口頭発表(一般)

  • Observation of Mastication in Patients Underwent Mandibular Reconstruction by 4D-CT with 320 Detector-Row Scanning : A Preliminary Report,

    Akashi M, Shibuya Y, Takahashi S, Hashikawa K, Hasegawa T, Kakei Y, Negi N, Sekitani T, Komori T

    22nd International conference on oral and maxilofacial surgery,, 2015年10月, 英語, メルボルン, オーストラリア, 国際会議

    口頭発表(一般)

  • Incidence of venousthromboembolism after oral surgery with simultaneous reconstruction,

    Kakei Y, Akashi M, Shigeta T, Takahashi Y, Mastui T, Sakakibara A, Hasegawa T, Minamikawa T, Komori T

    22nd International conference on oral and maxilofacial surgery,, 2015年10月, 英語, メルボルン, オーストラリア, 国際会議

    口頭発表(一般)

  • Evaluating the changes in the amount of bone augmentation after sinus lift using panoramic radiography: Comparison evaluations based on CT images.

    松尾 健司, 鈴木 泰明, 松本 耕祐, 木本 明, 長谷川 巧実, 明石 昌也, 竹内 順一郎, 古森 孝英

    第60回日本口腔外科学会総会., 2015年10月, 日本語, 日本口腔外科学会, 名古屋, 国内会議

    口頭発表(一般)

  • A novel strategy aimed at apoptosis via the mitochondrial pathway and improving hypoxia in oral squamous cell carcinoma..

    武田 大介, 長谷川 巧実, 榊原 晶子, 明石 昌也, 南川 勉, 古森 孝英

    第60回日本口腔外科学会総会, 2015年10月, 日本語, 日本口腔外科学会, 名古屋, 国内会議

    口頭発表(一般)

  • 当科における下顎の骨折線上の歯に関する臨床的検討

    北山 美登里, 鈴木 泰明, 小守 紗也華, 松本 耕祐, 明石 昌也, 古森 孝英

    第15回日本外傷歯学会,, 2015年07月, 日本語, 日本外傷歯学会, 福岡, 国内会議

    口頭発表(一般)

  • 混合歯列期の下顎骨骨折に対し非観血的整復治療を行った1例

    小守 紗也華, 松本 耕祐, 北山 美登里, 明石 昌也, 立石 千鶴, 鈴木 泰明, 古森 孝英

    第15回日本外傷歯学会,, 2015年07月, 日本語, 日本外傷歯学会, 福岡, 国内会議

    口頭発表(一般)

  • 当院における周術期口腔機能管理に関する実態調査と今後の課題

    田村 惠利, 西井 美佳, 冨田 和, 難波 渚, 長谷川 巧実, 明石 昌也, 古土井 春吾, 古森 孝英

    第12回日本口腔ケア学会総会・学術大会., 2015年06月, 日本語, 日本口腔ケア学会, 山口, 国内会議

    口頭発表(一般)

  • 外科的矯正手術前後における顎関節症状および顎関節MRI画像の変化.

    定兼 啓倫, 長谷川 巧実, 有本 智美, 岡本 奈那, 塩屋園 敦, 立石 千鶴, 明石 昌也, 鈴木 泰明, 古土井 春吾, 古森 孝英

    第25回日本顎変形症学会総会., 2015年06月, 日本語, 日本顎変形症学会, 東京, 国内会議

    口頭発表(一般)

  • Sequential evaluation of bone union of transferred fibula flaps in reconstructed mandibles.

    Akashi M, Hashikawa K, Kakei Y, Sakakibara A, Hasegawa T, Minamikawa T, Komori T

    "The Joint Meeting of 4th Congress of Asian Society of Head and Neck Oncology & 39th Annual Meeting of Japan society for Head and Neck Cancer., 2015年06月, 英語, 神戸, 国内会議

    口頭発表(一般)

  • Decreased mitochondrial copy numbers in oral squamous cell carcinoma.

    Takeda D, Hasegawa T, Sakakibara A, Akashi M, Minamikawa T, Komori T

    "The Joint Meeting of 4th Congress of Asian Society of Head and Neck Oncology & 39th Annual Meeting of Japan society for Head and Neck Cancer., 2015年06月, 英語, 神戸, 国内会議

    口頭発表(一般)

  • -

    難波 渚, 西井 美佳, 冨田 和, 田村 恵利, 長谷川 巧実, 明石 昌也, 古土井 春吾, 古森 孝英

    第12回日本口腔ケア学会総会・学術大会., 2015年06月, 日本語, 日本口腔ケア学会, 山口, 国内会議

    口頭発表(一般)

  • 下顎骨骨髄炎との鑑別が困難であった下顎歯肉悪性腫瘍の1例

    渡邊 一博, 古土井 春吾, 筧 康正, 明石 昌也, 南川 勉, 古森 孝英

    第46回日本口腔外科学会近畿支部学術集会., 2015年03月, 日本語, 日本口腔外科学会, 神戸, 国内会議

    口頭発表(一般)

  • 移植非骨と下顎骨の骨癒合に関する経時的評価-パノラマX線とCT画像の比較-

    明石 昌也, 橋川 和信, 榊原 晶子, 楠元 順哉

    第109回関西形成外科学会地方会., 2015年03月, 日本語, 関西形成外科学会, 京都, 国内会議

    口頭発表(一般)

  • 当科における頸部郭清術術後の頸部ドレーンに関する臨床的検討

    齊藤 泉, 長谷川 巧実, 米澤 奈津季, 武田 大介, 高橋 佑輔, 筧 康正, 松井 太輝, 榊原 晶子, 明石 昌也, 南川 勉, 古森 孝英

    第33回日本口腔腫瘍学会, 2015年01月, 日本語, 日本口腔腫瘍学会, 奈良, 国内会議

    口頭発表(一般)

  • 当科における放射線性顎骨壊死に関する臨床的検討

    鰐渕 聡, 明石 昌也, 筧 康正, 榊原 晶子, 長谷川 巧実, 南川 勉, 古森 孝英

    第33回日本口腔腫瘍学会, 2015年01月, 日本語, 日本口腔腫瘍学会, 奈良, 国内会議

    口頭発表(一般)

  • 当科における口腔扁平上皮癌遠隔転移例の臨床的検討とリスク因子について

    棚倉 万紀子, 長谷川 巧実, 米澤 奈津季, 武田 大介, 高橋 佑輔, 筧 康正, 榊原 晶子, 明石 昌也, 南川 勉, 古森 孝英

    第33回日本口腔腫瘍学会, 2015年01月, 日本語, 日本口腔腫瘍学会, 奈良, 国内会議

    口頭発表(一般)

  • 口腔扁平上皮癌臨床検体におけるミトコンドリア量について

    武田 大介, 長谷川 巧実, 今井 佑輔, 榊原 晶子, 明石 昌也, 南川 勉, 古森 孝英

    第33回日本口腔腫瘍学会, 2015年01月, 日本語, 日本口腔腫瘍学会, 奈良, 国内会議

    ポスター発表

  • 口腔癌手術症例におけるmodified Glasgow Prognostic Score(mGPS)を用いた長期予後に関する検討

    平岡 佑二郎, 南川 勉, 米澤 奈津季, 高橋 佑輔, 榊原 晶子, 長谷川 巧実, 明石 昌也, 古森 孝英

    第33回日本口腔腫瘍学会, 2015年01月, 日本語, 日本口腔腫瘍学会, 奈良, 国内会議

    ポスター発表

  • 口腔癌原発巣におけるDual-time-point FDG PETの有用性

    米澤 奈津季, 南川 勉, 高橋 佑輔, 筧 康正, 松井 太輝, 榊原 晶子, 長谷川 巧実, 明石 昌也, 古森 孝英

    第33回日本口腔腫瘍学会, 2015年01月, 日本語, 日本口腔腫瘍学会, 奈良, 国内会議

    口頭発表(一般)

  • 下顎枝垂直骨切り術後の近位骨片と下顎頭変化の評価

    有本 智美, 長谷川 巧実, 定兼 啓倫, 岡本 奈那, 塩屋園 敦, 立石 千鶴, 明石 昌也, 鈴木 泰明, 古土井 春吾, 古森 孝英

    第25回日本顎変形症学会総会., 2015年01月, 日本語, 日本顎変形症学会, 東京, 国内会議

    口頭発表(一般)

  • 放射線治療後の甲状腺機能低下による低ナトリウム血症の1例

    村田 陽太郎, 長谷川 巧実, 八橋 明子, 明石 昌也, 南川 勉, 古土井 春吾, 古森 孝英

    第26回日本口腔科学会近畿地方部会, 2014年12月, 日本語, 日本口腔科学会, 京都, 国内会議

    口頭発表(一般)

  • 歯科インプラント埋入のためのCT画像を用いた移植腓骨の形態評価

    明石 昌也, 橋川 和信, 榊原 晶子, 楠元 順哉

    第108回関西形成外科学会学術集会, 2014年12月, 日本語, 関西形成外科学会, 大阪, 国内会議

    口頭発表(一般)

  • 経口的ビタミンB12投与が著効したHUNTER舌炎の1例

    中田 和甫史, 若林 玲奈, 明石 昌也, 古森 孝英

    第26回日本口腔科学会近畿地方部会, 2014年12月, 日本語, 日本口腔科学会, 京都, 国内会議

    口頭発表(一般)

  • 当科における広範囲顎骨支持型インプラント補綴の臨床統計的検討

    今井 佑輔, 長谷川 巧実, 川畑 真哉, 武田 大介, 明石 昌也, 鈴木 泰明, 古森 孝英

    第18回日本顎顔面インプラント学会学術大会, 2014年11月, 日本語, 日本顎顔面インプラント学会, 島根, 国内会議

    口頭発表(一般)

  • 当科におけるインプラント242例907本埋入に関する臨床的検討

    川畑 真哉, 長谷川 巧実, 今井 佑輔, 木本 明, 明石 昌也, 鈴木 泰明, 古森 孝英

    第18回日本顎顔面インプラント学会学術大会, 2014年11月, 日本語, 日本顎顔面インプラント学会, 島根, 国内会議

    口頭発表(一般)

  • 著明な上顎洞粘膜肥厚を有する患者に洞底挙上術後インプラント治療を行った症例

    榎本 由依, 鈴木 泰明, 木本 明, 長谷川 巧実, 明石 昌也, 竹内 純一郎, 古森 孝英

    第18回日本顎顔面インプラント学会学術大会, 2014年11月, 日本語, 日本顎顔面インプラント学会, 島根, 国内会議

    口頭発表(一般)

  • 小児の顔面多発骨折症例の経験

    大﨑 健夫, 川北 育子, 北野 豊明, 桒水流 健二, 明石 昌也

    第32回日本頭蓋顎顔面外科学会学術集会, 2014年11月, 日本語, 日本頭蓋顎顔面外科学会, 大阪, 国内会議

    口頭発表(一般)

  • 歯科インプラント埋入のためのCT画像を用いた移植腓骨の形態評価

    明石 昌也, 渋谷 恭之, 鰐渕 聡, 木本 明, 長谷川 巧実, 鈴木 泰明, 古森 孝英

    第18回日本顎顔面インプラント学会学術大会, 2014年11月, 日本語, 日本顎顔面インプラント学会, 島根, 国内会議

    口頭発表(一般)

  • 入院加療を要した口腔頸部の重症感染症例の検討

    藤林 淳子, 古土井 春吾, 畑 みどり, 楠元 順哉, 後藤 育子, 明石 昌也, 古森 孝英

    第23回日本口腔感染症学会総会, 2014年10月, 日本語, 日本口腔感染症学会, 伊丹, 国内会議

    口頭発表(一般)

  • 頭頸部領域における壊死性筋膜炎に対するLRINECスコアの有用性の検討

    楠元 順哉, 古土井 春吾, 明石 昌也, 榊原 晶子, 古森 孝英

    第59回日本口腔外科学会総会, 2014年10月, 日本語, 日本口腔外科学会, 千葉, 国内会議

    口頭発表(一般)

  • 当科における口腔癌患者の術後せん妄に関する臨床的検討

    齊藤 泉, 長谷川 巧実, 米澤 奈津季, 高橋 佑輔, 筧 康正, 松井 太輝, 榊原 晶子, 明石 昌也, 南川 勉, 古森 孝英

    第59回日本口腔外科学会総会, 2014年10月, 日本語, 日本口腔外科学会, 千葉, 国内会議

    口頭発表(一般)

  • 当院における心臓血管外科患者における周術期口腔機能管理

    藤 大補, 明石 昌也, 古土井 春吾, 西井 美佳, 後藤 育子, 古森 孝英

    第23回日本口腔感染症学会総会, 2014年10月, 日本語, 日本口腔感染症学会, 伊丹, 国内会議

    口頭発表(一般)

  • 低出力超音波パルスの下顎骨骨折血腫細胞のBMP発現における効果

    黄 文蘇, 長谷川 巧実, 今井 佑輔, 武田 大介, 明石 昌也, 古森 孝英

    第59回日本口腔外科学会総会, 2014年10月, 日本語, 日本口腔外科学会, 千葉, 国内会議

    ポスター発表

  • 上顎部分切除後の遊離前腕皮弁再建群と非再建群の比較

    明石 昌也, 渋谷 恭之, 楠元 順哉, 榊原 晶子, 長谷川 巧実, 南川 勉, 古土井 春吾, 橋川 和信, 古森 孝英

    第59回日本口腔外科学会総会, 2014年10月, 日本語, 日本口腔外科学会, 千葉, 国内会議

    口頭発表(一般)

  • 抗RANKLモノクローナル抗体(デノスマブ)に発症した顎骨壊死の1例

    岩田 英治, 明石 昌也, 長谷川 巧実, 古土井 春吾, 古森 孝英

    第23回日本口腔感染症学会総会, 2014年10月, 日本語, 日本口腔感染症学会, 伊丹, 国内会議

    口頭発表(一般)

  • 口腔扁平上皮癌N0症例への予防的頸部郭清の検討:T1-2とT3-4の比較

    八橋 明子, 南川 勉, 松井 太輝, 高橋 佑輔, 米澤 奈津季, 筧 康正, 榊原 晶子, 長谷川 巧実, 明石 昌也, 古森孝英

    第59回日本口腔外科学会総会, 2014年10月, 日本語, 日本口腔外科学会, 千葉, 国内会議

    ポスター発表

  • 口腔癌手術における輸血療法の現状

    米澤 奈津季, 南川 勉, 高橋 佑輔, 筧 康正, 松井 太輝, 榊原 晶子, 長谷川 巧実, 明石 昌也, 渋谷恭之, 古森 孝英

    第59回日本口腔外科学会総会, 2014年10月, 日本語, 日本口腔外科学会, 千葉, 国内会議

    口頭発表(一般)

  • 口腔癌に対する救済手術についての検討

    筧 康正, 南川 勉, 米澤 奈津季, 高橋 佑輔, 松井 太輝, 榊原 晶子, 長谷川 巧実, 明石 昌也, 渋谷 恭之, 古森孝英

    第59回日本口腔外科学会総会, 2014年10月, 日本語, 日本口腔外科学会, 千葉, 国内会議

    口頭発表(一般)

  • 局所的炭酸ガス投与による口腔癌新規治療法の開発

    武田 大介, 長谷川 巧実, 今井 佑輔, 榊原 晶子, 明石 昌也, 南川 勉, 渋谷 恭之, 古森 孝英

    第59回日本口腔外科学会総会, 2014年10月, 日本語, 日本口腔外科学会, 千葉, 国内会議

    ポスター発表

  • 化学放射線療法中の中咽頭癌患者における口腔乾燥の経時的変化

    西井 美佳, 明石 昌也, 筧 康正, 長谷川 巧実, 南川 勉, 古土井 春吾, 渋谷 恭之, 古森 孝英

    第59回日本口腔外科学会総会, 2014年10月, 日本語, 日本口腔外科学会, 千葉, 国内会議

    口頭発表(一般)

  • フェーズラグCT(pl-CTA)による顎骨周囲の脈管の評価

    榊原 晶子, 榊原 俊介, 長谷川 巧実, 明石 昌也

    第59回日本口腔外科学会総会・学術集会, 2014年10月, 日本語, 日本口腔外科学会, 幕張, 国内会議

    口頭発表(一般)

  • フェーズラグCTA(pl-CTA)による顎動静脈分岐の評価

    榊原 晶子, 榊原 俊介, 楠元 順哉, 長谷川 巧実, 明石 昌也, 鈴木 泰明, 南川 勉, 古土井 春吾, 橋川 和信, 古森 孝英

    第59回日本口腔外科学会総会, 2014年10月, 日本語, 日本口腔外科学会, 千葉, 国内会議

    口頭発表(一般)

  • ビスフォスフォネート関連顎骨壊死症例のCT画像における臨床的検討

    岩田 英治, 明石 昌也, 楠元 順哉, 長谷川 巧実, 後藤 育子, 古土井 春吾, 古森 孝英

    第59回日本口腔外科学会総会, 2014年10月, 日本語, 日本口腔外科学会, 千葉, 国内会議

    ポスター発表

  • 対側オトガイ部の知覚異常を初発症状としたびまん性大細胞型B細胞性リンパ腫の1例

    高端 大希, 明石 昌也, 高橋 佑輔, 辻 和志, 西尾 良介, 南川 勉, 古森 孝英

    第45回日本口腔外科学会近畿地方会, 2014年06月, 日本語, 日本口腔外科学会, 奈良, 国内会議

    口頭発表(一般)

  • 口腔癌再建術後の感染性合併症-術後CRPのabnormal responseに注目して-

    明石 昌也, 橋川 和信, 南川 勉, 渋谷 恭之, 古森 孝英

    第38回日本頭頸部癌学会, 2014年06月, 日本語, 日本頭頸部癌学会, 東京, 国内会議

    口頭発表(一般)

  • 顎関節部に限局する線維-骨性病変の1例

    八橋 明子, 渋谷 恭之, 後藤 育子, 明石 昌也, 松井 太輝, 古森 孝英

    第45回日本口腔外科学会近畿地方会, 2014年06月, 日本語, 日本口腔外科学会, 奈良, 国内会議

    口頭発表(一般)

  • 過去15年間の高齢口腔癌患者に関する臨床的検討

    米澤 奈津季, 南川 勉, 高橋 佑輔, 明石 昌也, 渋谷 恭之, 古森 孝英

    第38回日本頭頸部癌学会, 2014年06月, 日本語, 日本頭頸部癌学会, 東京, 国内会議

    口頭発表(一般)

  • 栄養・輸液サポートチームにおける歯科的介入について

    若林 玲奈, 渋谷 恭之, 今井 佑輔, 黒木 信祐, 後藤 育子, 明石 昌也, 古土井 春吾, 古森 孝英

    第45回日本口腔外科学会近畿地方会, 2014年06月, 日本語, 日本口腔外科学会, 奈良, 国内会議

    口頭発表(一般)

  • 造血気悪性腫瘍患者への歯科的介入に関する前向き検討

    辻 和志, 渋谷 恭之, 岸本 恵実, 棚倉 万紀子, 明石 昌也, 古土井 春吾, 古森 孝英

    第68回日本口腔科学会学術総会, 2014年05月, 日本語, 日本口腔科学会, 東京, 国内会議

    口頭発表(一般)

  • 口腔内細菌数が放射線性口腔粘膜炎に及ぼす影響について

    後藤 育子, 古土井 春吾, 西井 美佳, 楠本 順哉, 梶 真人, 明石 昌也, 古森 孝英

    第68回日本口腔科学会学術総会, 2014年05月, 日本語, 日本口腔科学会, 東京, 国内会議

    ポスター発表

  • 口腔癌再建術後の頸部感染評価目的でのCTの有用性

    明石 昌也, 古土井 春吾, 南川 勉, 木本 明, 榊原 晶子, 長谷川 巧実, 後藤 育子, 渋谷 恭之, 古森 孝英

    第68回日本口腔科学会学術総会, 2014年05月, 日本語, 日本口腔科学会, 東京, 国内会議

    口頭発表(一般)

  • Preformed Reconstruction plateで下顎再建を行った2症例

    竹内 惇平, 古土井 春吾, 藤 大補, 高橋 佑輔, 明石 昌也, 榊原 晶子, 南川 勉, 渋谷 恭之, 古森 孝英

    第68回日本口腔科学会学術総会, 2014年05月, 日本語, 日本口腔科学会, 東京, 国内会議

    口頭発表(一般)

  • パネルディスカッション3. ビデオで伝えたい私の手順

    野村 正, 榊原 俊介, 高須 啓之, 明石 昌也, 橋川 和信, 田原 真也, 寺師 浩人

    第19回日本形成外科手術手技学会, 2014年02月, 日本語, 日本形成外科手術手技学会, 愛知, 国内会議

    公開講演,セミナー,チュートリアル,講習,講義等

  • 高齢口腔癌患者に関する臨床的検討

    米澤 奈津季, 南川 勉, 明石 昌也, 高橋 佑輔, 重田 崇至, 渋谷 恭之, 古森 孝英

    第32回日本口腔腫瘍学会, 2014年01月, 日本語, 日本口腔腫瘍学会, 札幌, 国内会議

    口頭発表(一般)

  • 口腔癌cN1症例に対する頸部郭清術の廓清範囲についての検討

    筧 康正, 南川 勉, 高橋 佑輔, 松井 太輝, 長谷川 巧実, 明石 昌也, 重田 崇至, 古土井 春吾, 渋谷 恭之, 古森 孝英

    第32回日本口腔腫瘍学会, 2014年01月, 日本語, 日本口腔腫瘍学会, 札幌, 国内会議

    口頭発表(一般)

  • 遊離腓骨皮弁移植におけるMR Angiographyによる下肢血管解剖の術前評価

    楠元 順哉, 橋川 和信, 明石 昌也, 榊原 晶子, 寺師 浩人

    第105回日本形成外科学会関西支部学術集会, 2013年12月, 日本語, 本形成外科学会, 大阪, 国内会議

    口頭発表(一般)

  • 口腔外に肉芽形成をきたしたビスフォスフォネート関連顎骨壊死の1例

    岩田英治, 古土井春吾, 楠元順哉, 後藤育子, 明石昌也, 古森孝英

    第25回日本口腔科学会近畿地方部会, 2013年12月, 日本語, 日本口腔科学会, 大阪, 国内会議

    口頭発表(一般)

  • 胃癌術後の腹壁再発切除術により生じた 胸腹壁欠損に対する治療経験

    長谷川 泰子, 野村 正, 明石 昌也, 前田 翔, 橋川 和信, 寺師 浩人

    第105回関西形成外科学会学術集会, 2013年12月, 日本語, 関西形成外科学会学術集会, 大阪市, 国内会議

    口頭発表(一般)

  • 片側性唇顎口蓋裂を伴う咬合不全に対し腓骨皮弁による骨再建とインプラント埋入術を行った成人男性の1例

    齊藤 泉, 渋谷恭之, 筧 康正, 明石昌也, 重田崇至, 古森孝英

    第17回顎顔面インプラント学会総会, 2013年11月, 日本語, 顎顔面インプラント学会, 東京, 国内会議

    口頭発表(一般)

  • 当科における重症性感染症例の臨床的検討

    藤林淳子, 古土井春吾, 小松原秀紀, 楠元順哉, 後藤育子, 明石昌也, 古森孝英

    第22回口腔感染症学会総会, 2013年11月, 日本語, 口腔感染症学会, 八王子, 国内会議

    口頭発表(一般)

  • 呼吸サポートチームへの歯科介入がVAP予防に与える影響について

    後藤育子, 古土井春吾, 西井美佳, 四宮麻美, 楠元順哉, 梶 真人, 明石昌也, 渋谷恭之, 古森孝英

    第22回口腔感染症学会総会, 2013年11月, 日本語, 口腔感染症学会, 八王子, 国内会議

    口頭発表(一般)

  • 超高純度マグネシウムを用いて生体吸収性金属製骨接合プレートを作製する

    橋川 和信, 髙須 啓之, 明石 昌也, 寺師 浩人

    第31回日本頭蓋顎顔面外科学会学術集会, 2013年10月, 日本語, 日本頭蓋顎顔面外科学会学術集会, 名古屋市, 国内会議

    口頭発表(一般)

  • 舌半側切除後の遊離前腕皮弁再建症例における長期観察結果.

    明石 昌也, 橋川 和信, 榊原 晶子, 長谷川 巧実, 重田 崇至, 南川 勉, 古土井 春吾, 渋谷 恭之, 古森 孝英

    第58回日本口腔外科学会総会・学術大会, 2013年10月, 日本語, 日本口腔外科学会総会・学術大会, 福岡市, 国内会議

    口頭発表(一般)

  • 口腔癌患者における胃瘻造設に関する検討―術中同時胃瘻造設について-

    米澤奈津季, 南川 勉, 明石昌也, 高橋佑輔, 長谷川巧実, 榊原晶子, 重田崇至, 渋谷恭之, 古森孝英

    第58回日本口腔外科学会総会, 2013年10月, 日本語, 日本口腔外科学会, 福岡, 国内会議

    口頭発表(一般)

  • 口腔癌における周術期静脈血栓塞栓症について

    筧 康正, 南川 勉, 高橋佑輔, 松井太輝, 榊原晶子, 明石昌也, 重田崇至, 古土井春吾, 渋谷恭之, 古森孝英

    第58回日本口腔外科学会総会, 2013年10月, 日本語, 日本口腔外科学会, 福岡, 国内会議

    口頭発表(一般)

  • シスプラチン併用化学放射線療法の術後補助療法としての有効性に関する検討

    重田崇至, 南川 勉, 松井太輝, 明石昌也, 長谷川巧実, 高橋佑輔, 筧 康正, 渋谷恭之, 梅田正博, 古森孝英

    第58回日本口腔外科学会総会, 2013年10月, 日本語, 日本口腔外科学会, 福岡, 国内会議

    口頭発表(一般)

  • 再発口腔中咽頭癌に対する遊離皮弁再建に関する検討.

    明石 昌也, 橋川 和信, 寺師 浩人

    第40回日本マイクロサージャリー学会学術集会, 2013年09月, 日本語, 日本マイクロサージャリー学会学術集会, 盛岡市, 国内会議

    口頭発表(一般)

  • 再発口腔中咽頭癌に対する遊離皮弁再建における問題点-第2報-

    明石昌也, 橋川和信, 寺師浩人

    第40回日本マイクロサージェリー学会総会, 2013年09月, 日本語, 日本マイクロサージェリー学会, 岩手, 国内会議

    口頭発表(一般)

  • 舌半側切除後の遊離前腕皮弁再建症例における長期観察結果.

    明石 昌也, 橋川 和信, 榊原 晶子, 寺師 浩人

    第37回日本頭頸部癌学会, 2013年06月, 日本語, 日本頭頸部癌学会, 東京都, 国内会議

    口頭発表(一般)

  • 再発口腔中咽頭癌に対する遊離皮弁再建における問題点

    明石 昌也, 橋川 和信, 寺師 浩人

    第37回日本頭頸部癌学会総会, 2013年06月, 日本語, 日本頭頸部癌学会, 東京, 国内会議

    口頭発表(一般)

  • がん切除後下顎再建における再建理論「CATコンセプト」.

    橋川 和信, 明石 昌也, 野村 正, 寺師 浩人

    第37回日本頭頸部癌学会, 2013年06月, 日本語, 日本頭頸部癌学会, 東京都, 国内会議

    口頭発表(一般)

  • 造血器悪性腫瘍患者への歯科的介入に関する前向き検討

    辻 和志, 渋谷恭之, 明石昌也, 古土井春吾, 古森孝英

    第67回日本口腔科学会総会, 2013年05月, 日本語, 日本口腔科学会, 宇都宮, 国内会議

    口頭発表(一般)

  • 放射線誘発癌が疑われた口腔癌に対する遊離皮弁再建

    明石 昌也, 橋川 和信, 寺師 浩人

    第103回関西形成外科学会学術集会, 2013年03月, 日本語, 関西形成外科学会学術集会, 大阪市, 国内会議

    口頭発表(一般)

  • 舌癌180例のリンパ節転移に関する検討~健側転移について~

    松井太輝, 重田崇至, 南川 勉, 明石昌也, 高橋佑輔, 筧 康正, 古土井春吾, 渋谷恭之, 古森孝英

    第31回日本口腔腫瘍学会総会, 2013年01月, 日本語, 日本口腔腫瘍学会, 東京, 国内会議

    口頭発表(一般)

  • 口腔扁平上皮癌術後局所再発症例に関する検討

    高橋佑輔, 南川 勉, 筧 康正, 松井太輝, 榊原晶子, 明石昌也, 重田崇至, 渋谷恭之, 古森孝英

    第31回日本口腔腫瘍学会総会, 2013年01月, 日本語, 日本口腔腫瘍学会, 東京, 国内会議

    口頭発表(一般)

  • 口腔扁平上皮癌T4症例に対する手術療法の治療成績

    筧 康正, 南川 勉, 高橋佑輔, 松井太輝, 榊原晶子, 明石昌也, 重田崇至, 古土井春吾, 渋谷恭之, 古森孝英

    第31回日本口腔腫瘍学会総会, 2013年01月, 日本語, 日本口腔腫瘍学会, 東京, 国内会議

    口頭発表(一般)

  • Facial artery musculomucosal flapにより口腔上顎洞瘻孔を治療した1例

    明石 昌也, 橋川 和信, 大澤 沙由理, 寺師 浩人

    第30回日本頭蓋顎顔面外科学会学術集会, 2012年11月, 日本語, 日本頭蓋顎顔面外科学会, 豊中, 国内会議

    口頭発表(一般)

  • 遊離腓骨皮弁移植におけるMR Angiographyと超音波検査による下肢血管解剖の術前評価

    明石 昌也, 橋川 和信, 榊原 晶子, 長谷川 巧実, 重田 崇至, 南川 勉, 古土井 春吾, 渋谷 恭之, 古森 孝英

    第57回日本口腔外科学会総会・学術大会, 2012年10月, 日本語, 日本口腔外科学会, 横浜, 国内会議

    口頭発表(一般)

  • 下顎骨区域欠損に対する再建理論「CATコンセプト」の実践

    橋川 和信, 明石 昌也, 榊原 晶子

    第57回日本口腔外科学会総会・学術大会, 2012年10月, 日本語, 日本口腔外科学会, 横浜, 国内会議

    口頭発表(一般)

  • 外傷後に生じたclaw toe変形に対し長趾屈筋移行術を施行した1例

    髙須 啓之, 橋川 和信, 明石 昌也, 寺師 浩人

    第101回日本形成外科学会関西支部学術集会, 2012年07月, 日本語, 日本形成外科学会関西支部, 大阪, 国内会議

    口頭発表(一般)

  • 金属製再建プレートによる下顎骨再建後の合併症について-下顎骨硬性再建に関する一考察

    明石 昌也, 橋川 和信, 榊原 晶子, 榊原 俊介, 横尾 聡, 寺師 浩人, 田原 真也

    第55回日本形成外科学会総会・学術集会, 2012年04月, 日本語, 日本形成外科学会, 東京, 国内会議

    口頭発表(一般)

  • プレート破折後に遊離腓骨皮弁で下顎骨再建を行った1例

    明石 昌也, 橋川 和信, 田原 真也

    第99回日本形成外科学会 関西支部学術集会, 2011年12月, 日本語, 日本形成外科学会, 京都, 国内会議

    口頭発表(一般)

  • Protective immune response by intranasal immunization with split-virion influenza A vaccine with adjuvant and whole-viron influenza A vaccine

    Okamoto S, Matsuoka S, Yamada H, Gomi Y, Okuno Y, Akagi T, Akashi M, Mori Y, Yamanishi K

    Cell Symposia: Influenza - Translating basic insights, 2010年12月, 英語, Elsevier(Cell Press), Washington DC, アメリカ合衆国, 国際会議

    口頭発表(一般)

  • Impaired stratum corneum formation in claudin-1-deficient mice with defect in tight junction function

    Sugawara T, Akashi M, Yuki T, Nakagawa N, Sakai S, Sugiyama Y, Inoue S, Furuse M

    第35回日本研究皮膚科学会総会, 2010年12月, 英語, 日本研究皮膚科学会, 和歌山, 国内会議

    口頭発表(一般)

  • 口腔癌手術における嚥下改善手術に関する臨床的検討.

    明石 昌也, 南川 勉, 高橋英哲, 小國 晶子, 橋川 和信, 古土井 春吾, 渋谷 恭之, 梅田 正博, 古森孝英

    第55回日本口腔外科学会総会, 2010年10月, 日本語, 日本口腔外科学会, 千葉, 国内会議

    口頭発表(一般)

共同研究・競争的資金等の研究課題

  • 食品基礎科学を応用した新規咀嚼機能評価法の開発とオーラルフレイルへの波及効果

    渋谷 恭之, 高岡 素子, 桐田 忠昭, 梅田 正博, 栗田 浩, 明石 昌也, 前田 道徳

    日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C), 名古屋市立大学, 2020年04月01日 - 2024年03月31日

  • 血管・リンパ管新生に着眼した歯性感染症-顎骨骨髄炎移行メカニズム解明と治療法探索

    明石 昌也, 木本 明, 長谷川 巧実, 筧 康正

    日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C), 神戸大学, 2019年04月01日 - 2023年03月31日

    骨粗鬆症などに対し用いられる骨吸収抑制薬や、口腔癌に対し施行される放射線照射等の医療行為が素因となる顎骨骨髄炎は、近年患者数の増加に伴い顎口腔外科領域において最も新たな治療法開発が期待される難治性疾患の一つである。本研究の目的は、近年感染の進展にも関与していることが明らかとなりつつある血管・リンパ管新生をターゲットとし、歯性感染症-顎骨骨髄炎移行メカニズムを解明することである。 研究の端緒として、まず血管新生のマーカーとなりうる分子の検討を行なった。近年動脈硬化や高血圧、腫瘍の増大における病的な状態における血管新生に関与している可能性が示唆されている血管内皮細胞間接着複合体構成分子に注目した。この分子についてはマウスやヒト培養細胞を用いた研究はこれまでに行われてきたが、ヒトの組織内での発現や局在部位を確認した報告は稀少であった。当該年度の研究結果より、この分子がヒトの組織内でも特に非炎症部位の血管に比べ炎症部位の微小血管等に発現が強く、病的な血管のマーカーとなり得る可能性が示唆された。

  • 長谷川 巧実, 明石 昌也, 武田 大介

    日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C), 神戸大学, 2018年04月01日 - 2022年03月31日

    近年、局所的に炭酸ガスを効率的に吸収させることのできる炭酸ガス投与法を開発し、それを扁平上皮癌に応用した。その結果、腫瘍内の低酸素環境改善やミトコンドリア経路のアポトーシスの活性化によって癌の増殖抑制が起こることを発見した。さらに、上皮間葉移行(EMT)低下によるリンパ節転移の抑制がおこることを確認した。本研究の目的は、この局所的炭酸ガス投与を応用し、①腫瘍免疫抑制と治療抵抗性に対する改善効果と、②既存治療の副作用軽減効果を調査し、低リスク・低コストの新規口腔癌治療の開発を目指すことである。in vivoの研究において、5週齢のヌードマウス背部にHSC-3を皮下移植し、各治療法別(control群、RT群、CDDP群、CO2群、RT+CO2群、CDDP+CO2群)に検討した。局所的炭酸ガス投与は、われわれが過去に報告した方法で行った。各群より腫瘍を採取し、RNAを回収し、Real-time PCR法で計測した。RT+CO2群で、RT群に比較し、腫瘍の増加抑制効果を認め、低酸素誘導因子(HIF-1α)の減少、アポトーシス関連因子(PARP, Caspase3, 8, 9)の増加、さらに活性酸素関連因子(ROMO-1)の増加を認めた。また、骨髄抑制の副作用はRT単独群で、もっとも増加し、RT+CO2群である併用群ではむしろ改善傾向であった。また、抗癌剤(CDDP)との検討において、NF-kB、MDR1、CD44では、Control群に比較し、CDDP群では変化なく、CO2群やCDDP+CO2群において、減少していた。したがって、経皮的炭酸ガス投与は口腔扁平上皮癌に対し腫瘍内低酸素環境を改善し、抗癌剤(CDDP)および放射線治療と併用することで腫瘍縮小効果の増大が期待できることや副作用軽減効果があることが示唆された。腫瘍免疫抑制関連因子については現在検討中である。

    競争的資金

  • メタボローム解析を用いたARONJに対する新規LED治療の開発

    鈴木 泰明, 古森 孝英, 明石 昌也, 近津 大地, 木本 明

    日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C), 神戸大学, 2017年04月01日 - 2021年03月31日

    我が国で現在推奨されている骨吸収抑制薬関連顎骨壊死(Anti-resorptive agents-related osteonecrosis of the jaw: ARONJ)の治療は、科学的エビデンスに基づくものではなく、これまでの症例の集積と専門家の意見の集約にすぎない。国外では以前より「低反応レベルレーザー治療(Low reactive Level LaserTherapy: LLLT)」が適応され、文献での有用性がシステマティックに検証されている。日本口腔外科学会を含む関連6学会で更新された『ポジションペーパー2016』でも今後明らかにすべき検討課題とされ、我が国でもLLLT研究への積極的な取組みが急務である。このエビデンス獲得のため我々はメタボローム解析の適用を着想した。近年、LLLTはレーザー以外にLED等の光源も含め「低反応レベル光治療」として認知されつつあり、LED光のARONJに対する有効性を見出し、レーザーよりも安価で簡便なLEDによる新規のARONJ治療機器開発へつなげることを目指すべく本研究を開始した。 作年度までに、培養口腔内常在菌に対するLED照射効果の解析を行った。BRONJ発症への関与が報告されているレンサ球菌と放線菌を対象に、405、630、950nmの波長で照射を行い、LED照射群とLED非照射群(コントロール群)の生存細菌数を比較した。今年度は、BP 製剤を添加したヒト培養口腔扁平上皮細胞(HNOKs)と骨髄造血幹細胞(CD34+)に関して、LED光照射を行い、経時的な比較検討を行う予定であったが、予備実験の段階のため、解析に至っていない。今後、さらに条件を整えた上で進めていく予定である。

  • 古土井 春吾, 古森 孝英, 明石 昌也, 筧 康正

    日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C), 神戸大学, 2017年04月01日 - 2020年03月31日

    骨格筋機能的磁気共鳴画像(muscle functional Magnetic Resonance Image:mfMRI)の機能画像を用いて、健常被験者で安静時と咀嚼時の咀嚼筋について運動前後におけるT2値の変化(ΔT2)を測定したところ、咀嚼時の両側咬筋のΔT2上昇が確認された。咀嚼筋の形態的標準化が可能となった。続いて、口腔癌再建患者にmfMRIを応用すると、健側は術前と同様の形態と筋量が維持されており、咀嚼力は維持されていると考えられた。一方、患側は手術により切除されていることから、形態は変化して筋量は縮小しており、咀嚼力は低下していることが示唆された。

    競争的資金

  • 鈴木 泰明

    学術研究助成基金助成金/基盤研究(C), 2017年04月 - 2020年03月

    競争的資金

  • 明石 昌也

    日本学術振興会, 科学研究費助成事業 若手研究(B), 若手研究(B), 神戸大学, 2015年04月01日 - 2019年03月31日, 研究代表者

    癌の制御とリンパ管との関わりについて理解を深めるため、リンパ管内皮細胞に対する放射線照射の影響を、細胞間接着複合体の形態(morphology of cell junctions)や強度(integrity)、透過性(permeability)、直線性(linearity)を指標に評価した。その結果、放射線照射の影響によりリンパ管内皮細胞の変化が明らかとなり、癌のリンパ節転移や放射線照射後のリンパ浮腫等の合併症の発症メカニズムへの理解に寄与することが出来た。

    競争的資金

  • 明石 昌也

    日本学術振興会, 科学研究費助成事業 若手研究(B), 若手研究(B), 神戸大学, 2011年04月28日 - 2015年03月31日, 研究代表者

    リンパ管内皮細胞は正常な機能を維持するため細胞間結合により調節されている。本研究の目的の一つは、リンパ管内皮細胞の細胞間結合の特質性を明らかにこと、炎症性サイトカインTNF-αの細胞間結合に対する影響を解析することであった。 培養ヒト皮膚リンパ管内皮細胞(HDLEC)を密着結合マーカー、接着結合マーカー(VE-cadherin)で免疫染色し、TNF-α処理HDLECで同じ免疫染色と経内皮電気抵抗値を測定した。 その結果、野生型HDLECにおいて連続的・非連続的細胞間結合が混在していること、TNF-αは野生型における細胞間結合を変化させ、リンパ管内皮細胞のバリアに影響を与えていることが示唆された。

    競争的資金