熊本 悦子 | ![]() |
クマモト エツコ | |
DX・情報統括本部 | |
教授 | |
工学その他 |
2014年09月 Interventional MRI Symposium 2014, Interventional MRI Symposium 2014, Poster Award, magna cum laude., Respiratory-induced Deformation Analysis of Liver using Branching Structure of Portal Vein for MR Images for HIFU
ドイツ連邦共和国国際学会・会議・シンポジウム等の賞
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研究論文(学術雑誌)
As a kind of data that can reflect learning status, e-book logs have been widely used in learning analytics, especially for the prediction of academic performance. However, the best prediction model cannot be found without determining the contribution of e-book logs to the prediction performance of the model and its creation process. To this end, this study used the scikit-learn, a free software machine learning library, to analyze learning performance of 234 participants by learning behavior logs, which were collected by an e-book system. Finally, six prediction models containing Decision Tree, Random Forests, XGBoost, Logistic Regression, Support Vector Machines, and K-nearest Neighbors were created. Also, the contribution of e-book logs on the establishment of different prediction models was obtained by three feature importance calculation methods, i.e., the impurity-based feature importance, coefficients feature importance, and permutation feature importance. Based on statistical results, it was concluded that the Decision Tree and Random Forests had the best prediction performance, which was compared to the other four models, with prediction performance scores ranging from 0.7 to 0.8. Besides, the four data features of Prev, Highlight, Maker, and Next were found to have the greatest impact on model prediction creation.
2021年07月, Proceedings - IEEE 21st International Conference on Advanced Learning Technologies, ICALT 2021, 187 - 189研究論文(国際会議プロシーディングス)
研究論文(国際会議プロシーディングス)
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研究論文(国際会議プロシーディングス)
Thermometry is the key factor for achieving successful thermal therapy. Although invasive thermometry with a probe has been used for more than four decades, this method can only detect the local temperature within the probing volume. Noninvasive temperature imaging using a tomographic technique is ideal for monitoring hot-spot formation in the human body. Among various techniques, such as X-ray computed tomography, microwave tomography, echo sonography, and magnetic resonance (MR) imaging, the proton resonance frequency shift method of MR thermometry is the only method currently available for clinical practice because its temperature sensitivity is consistent in most aqueous tissues and can be easily observed using common clinical scanners. New techniques are being proposed to improve the robustness of this method against tissue motion. MR techniques for fat thermometry were also developed based on relaxation times. One of the latest non-MR techniques to attract attention is photoacoustic imaging.
Elsevier BV, 2020年, Advanced Drug Delivery Reviews, 163-164, 19 - 39, 英語, 国際誌[査読有り][招待有り]
研究論文(学術雑誌)
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研究論文(国際会議プロシーディングス)
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研究論文(国際会議プロシーディングス)
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研究論文(大学,研究機関等紀要)
In this paper, we presented a study developing a digital textbook system, which could be used anywhere, anytime. An experiment was conducted using the developed system to collect students' learning logs for analyzing their behavioral patterns on an Educational Technology course for graduate students. In the experiment, we assigned the students to read an academic English journal article. The lag-sequential analysis method was employed to analyze and infer their behavioral patterns. Several interesting behavioral patterns were found from the analysis results. The findings are helpful to the improvement of the digital textbook system; moreover, some behavioral patterns could provide helpful references for teachers to improve teaching materials in the future.
ASIA PACIFIC SOC COMPUTERS IN EDUCATION, 2017年12月, Proc. of 25th International Conference on Computers in Education 2017 (ICCE2017), 549 - 557, 英語[査読有り]
研究論文(国際会議プロシーディングス)
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研究論文(国際会議プロシーディングス)
Nowadays, it is easy to create digital books. However, through many university teachers create their own digital books as their teaching materials, it is difficult to evaluate and improve. In this paper, based on our previous research on the learning behavior analysis results, we prototype a digital book reading system and analyze the student reading logs and show how teachers can use the results to improve their teaching.
ATLANTIS PRESS, 2017年03月, PROCEEDINGS OF THE 2017 INTERNATIONAL CONFERENCE ON ADVANCED TECHNOLOGIES ENHANCING EDUCATION (ICAT2E 2017), 68, 90 - 96, 英語[査読有り]
研究論文(国際会議プロシーディングス)
We currently utilize the Moodle learning management system for teachers and students who participate in the course 'College of Liberal Arts and Sciences' at Kobe University in Japan. Digital textbooks, reports, quizzes and questionnaires in this course were administered using Moodle. In this paper, we proposed to use quizzes to measure and evaluate those digital textbooks recorded on Moodle. At the beginning of our study, we examined the questions that students got lower scores, and then we found the related teaching materials of digital textbooks and feedback to the teachers in order to improve the content of these digital textbooks.
2016年11月, Proc. of 24th International Conference on Computers in Education 2016 (ICCE2016), 374 - 379, 英語[査読有り]
研究論文(国際会議プロシーディングス)
Magnetic resonance-guided focused ultrasound (MRgFUS) is becoming one of the foremost treatment options for uterine fibroids and breast cancer. For an abdominal organ such as the liver however, a target tracking technique to “lock on” the focal area is required because the organ moves and deforms with respiratory motion. The technique, which is based on the relative displacemen
Japan Soc. of Med. Electronics and Biol. Engineering, 2015年10月29日, 生体医工学, 53 (3), 168 - 178, 日本語[査読有り]
研究論文(学術雑誌)
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研究論文(国際会議プロシーディングス)
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研究論文(国際会議プロシーディングス)
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研究論文(国際会議プロシーディングス)
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研究論文(国際会議プロシーディングス)
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研究論文(国際会議プロシーディングス)
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研究論文(国際会議プロシーディングス)
The MR-endoscope system can perform magnetic resonance (MR) imaging during endoscopy and show the images obtained by using endoscope and MR. The MR-endoscope system can acquire a high-spatial resolution MR image with an intraluminal radiofrequency (RF) coil, and the navigation system shows the scope's location and orientation inside the human body and indicates MR images with a scope view. In order to conveniently perform an endoscopy and MR procedure, the design of the user interface is very important because it provides useful information. In this study, we propose a navigation system using a wireless accelerometer-based controller with Bluetooth technology and a navigation technique to set the intraluminal RF coil using the navigation system. The feasibility of using this wireless controller in the MR shield room was validated via phantom examinations of the influence on MR procedures and navigation accuracy. In vitro examinations using an isolated porcine stomach demonstrated the effectiveness of the navigation technique using a wireless remote-control device.
2013年, Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, 2013, 5698 - 701, 英語, 国際誌[査読有り]
研究論文(国際会議プロシーディングス)
The goal of this study is to establish novel medical technologies by combining magnetic resonance imaging (MRI) with endoscopy to improve diagnostic precision and the safety of endoscopic surgeries. One of the key components of the integrated magnetic resonance (MR) endoscope system is a radio-frequency (RF) coil; this detects the MR signal from tissue and should be placed inside the body. Resonance characteristics such as the resonant frequency and the impedance of the RF coil, which affect the quality of MR images, change depending on the electric properties of the surrounding tissue and the coil deformation. Therefore, the technique of remote tuning and matching of the RF coil was developed, and its feasibility was investigated using a developed intracavitary RF coil, 1.5 tesla MR scanner, and models of phantom and resected porcine stomach. As a result, the frequency tuning and impedance matching was remotely adjusted in both models. In addition, the signal-to-noise ratio (SNR) of MR images was improved up to 134%. The developed remote tuning and matching technique was able to adjust the resonant characteristics of RF coil and can contribute the improvement of MR image quality, which would facilitate safe and precise endoscopy and endoscopic surgeries.
IEEE, 2013年, 2013 35TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC), 5706 - 5710, 英語[査読有り]
研究論文(国際会議プロシーディングス)
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研究論文(国際会議プロシーディングス)
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研究論文(国際会議プロシーディングス)
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研究論文(国際会議プロシーディングス)
The purpose of this study was to evaluate a novel vessel-tracking-based technique for tracking of human liver. The novelty of the proposed technique is that it measures the translation and deformation of a local tissue region based on the displacements of a set of vessels of interest instead of the entire organ. The position of the target point was estimated from the relative positions of the center-of-masses of the vessels, assuming that the topological relationship between the target point and center-of-masses is unchanged during breathing. To reduce inaccuracy due to the delay between vessel image acquisition and sonication, the near-future target position was predicted based on the vessel displacements in the images extracted from an image library acquired before the tracking stage. Experiments on healthy volunteers demonstrated that regardless of the respiratory condition, appropriate combinations of three center-of-masses from the vessels situated around the target-tissue position yielded an estimation error of less than 2 mm, which was significantly smaller than that obtained when using a single center-of-mass trio. The effect of the tracking delay was successfully compensated, with a prediction error of less than 3 mm, by using over four images selected from the image library. Magn Reson Med, 2011. (C) 2011 Wiley-Liss, Inc.
WILEY-BLACKWELL, 2012年01月, MAGNETIC RESONANCE IN MEDICINE, 67 (1), 156 - 163, 英語[査読有り]
研究論文(学術雑誌)
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研究論文(国際会議プロシーディングス)
Purpose The laparoscope has been invaluable in minimally invasive surgery, but provides only a surface view of target tissue; therefore it is lacking internal tissue information. In combination with the laparoscope for visualizing the cross-sectional view of the tissue, MRI is superior to ultrasonography or X-ray CT, because of its high soft-tissue contrast, arbitrary slice orientation and lack of radiation properties. Thus, we propose an integrated MR-laparoscopy system with a respiratory-synchronized navigation. Methods A transmit/receive RF coil for localized MR imaging with a 0.5 T open-MRI was mounted onto the tip of an MR-compatible laparoscope. The signal detection of the coil was examined with an excised porcine liver sample, an agar phantom and the abdominal wall of a healthy volunteer. A real-time navigation system to compensate for respiratory motion was developed, and examined with a healthy volunteer. Results The SNRs of the local MR images were 112, 62, and 62 in the liver sample, phantom, and volunteer. The navigation system successfully displayed the scope view, scope location and orientation, and MR images with respiratory-synchronized real time operation. Conclusions The MR-imaging and synchronization function of the proposed system seemed to be helpful for laparoscopic surgery.
SPRINGER TOKYO, 2010年09月, JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES, 17 (5), 622 - 628, 英語[査読有り]
研究論文(学術雑誌)
Recently, several new endoscopic instruments have been developed. However, even with the full use of current modalities, the safety of endoscopic surgery is not guaranteed. Information regarding factors such as fibrosis and the blood vessels under the mucosa is very important for avoiding procedure-related complications. The aim of this study was to define the detailed anatomy of the gastric wall structure in vivo using original endoluminal radiofrequency coils for safer endoscopic therapy.Swine were used as the subjects and controlled with general anesthesia. Anatomical images were obtained with T1-weighted fast spin echo (T1FSE) and T2-weighted fast spin echo (T2FSE). Dynamic magnetic resonance (MR) angiography was also obtained with three-dimensional T1-weighted fast spoiled gradient recalled acquisition in the steady state (3D-DMRA) following the injection of hyaluronic acid sodium into the submucosal layer.Porcine gastric wall structure was visualized, and four layers were discriminated in the T1FSE and T2FSE images. The vascular structure was clearly recognized in the submucosa on 3D-DMRA.Endoluminal MR imaging was able to visualize the porcine stomach with similar quality to endoscopic ultrasonography imaging. Additionally, it was possible to visualize the vascular structures in the submucosal layer. This is the first report to show that blood vessels under the gastric mucosa can be depicted in vivo.
SPRINGER JAPAN KK, 2010年06月, JOURNAL OF GASTROENTEROLOGY, 45 (6), 600 - 607, 英語[査読有り]
研究論文(学術雑誌)
研究論文(国際会議プロシーディングス)
The purpose of this study was to visualize the gastric wall layers and to depict the vascular architecture in vitro by using resected porcine stomachs studied with high-spatial resolution magnetic resonance (MR) imaging. Normal dissected porcine stomach samples (n = 4) were examined with a 3 Tesla MR system using a newly developed surface coil. MR images were obtained by the surface coil as receiver and a head coil as transmitter. High-spatial-resolution spin-echo MR images were obtained with a field of view of 8 x 8 cm, a matrix of 256 x 128 and slice thicknesses of 3 and 5 mm. T1 and T2-weighted MR images clearly depicted the normal porcine gastric walls as consisting of four distinct layers. In addition, vascular architectures in proper muscle layers were also visualized, which were confirmed by histological examinations to correspond to blood vessels. High-spatial-resolution MR imaging using a surface coil placed closely to the gastric wall enabled the differentiation of porcine gastric wall layers and the depiction of the blood vessels in proper muscle layer in this experimental study.
SPRINGER TOKYO, 2009年05月, JOURNAL OF GASTROENTEROLOGY, 44 (5), 390 - 395, 英語[査読有り]
研究論文(学術雑誌)
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研究論文(国際会議プロシーディングス)
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研究論文(国際会議プロシーディングス)
本研究の狙いは, 呼吸性の移動・変形をする肝臓内に設定した治療目標部位に対して, 治療用超音波の焦点をガイドするための磁気共鳴技術の開発である. ここに提案する我々の方法では血管を肝組織の追尾に使うこととした. 自由呼吸下における肝の矢状面におけるシネ画像をフィルタリングすることによって血管断面の重心を求め, それを解析することにより肝組織の並進距離と伸縮距離を解析した. 超音波焦点を置くべき治療目標点を, 血管の瞬時位置に基づいて推定した. 2名の健常ボランティアに対する実験において血管輪郭を描くためには, 空間マトリクスの大きさとして128×128が必要であった. 肝の並進距離は頭尾方向において19.6±3.6 mm, 腹背方向において3.1±1.4 mmであった. 伸縮距離は頭尾方向において3.7±1.1 mm, 腹背方向において3.0±1.2 mmであった. 検討に用いた血管の組み合わせでは, 目標点の実測位置と推定位置のずれが, 頭尾方向で0.7±0.5 mm, 腹背方向で0.6±0.4, 直線距離にして1.0±0.5 mmであった. 生体熱伝導方程式によって温度上昇をシミュレートした結果, 完全に息止めをした場合に較べて, 焦点周囲における肝組織の温度上昇のロスは20%程度であった. これらの結果は, 血管重心位置の実測に基づく提案法が臓器内の特定部位の動的な捕捉と, 加温領域をカバーする温度分布撮像面の追尾に, 十分な能力を有することを示した.
Japanese Society for Thermal Medicine, 2007年12月20日, 日本ハイパーサーミア学会誌 = Japanese journal of hyperthermic oncology, 23 (4), 181 - 193, 英語The purpose of this work is to develop a magnetic resonance (MR) technique for guiding a focal point created in Focused Ultrasound Surgery (FUS) onto a specific target position in an abdominal organ, such as the liver, which moves and deforms with respiratory motion. The translational distance, rotational angles, and amount of expansion and contraction of the organ tissue were measured by obtaining the gravity points of the veins filtered from the sagittal, cine MR images of healthy livers during free breathing. Using the locations of the vessels at each time point, the target position at which the ultrasound focus was to be placed was estimated. In the volunteer experiments (N = 2), the lower limit of the spatial matrix dimension for delineating the veins was 128 x 128. The average displacement of the liver was 19.6 +/- 3.6 mm in superior-inferior (SI) direction and 3.1 +/- 1.4 mm in anterior-posterior (AP) direction. The deformations were 3.7 +/- 1.1 mm in SI direction and 3.0 +/- 1.2 mm in AP direction. The error between the actual and the estimated target point was 0.7 +/- 0.5 mm in SI direction, 0.6 +/- 0.4 mm in AP direction and 1.0 +/- 0.5 mm in distance, and less than 2.1 mm in all the trials. These results suggested that the proposed technique is sufficient for targeting the focus on a specific tissue location and for tracking the slice slab for thermometry to cover the region of focus.
2007年, Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2007, 2614 - 7, 英語, 国際誌研究論文(学術雑誌)
The purpose of this work is to develop a magnetic resonance (MR) technique for guiding a focal point created in Focused Ultrasound Surgery (FUS) onto a specific target position in an abdominal organ, such as the liver, which moves and deforms with respiratory motion. The translational distance, rotational angles, and amount of expansion and contraction of the organ tissue were measured by obtaining the gravity points of the veins filtered from the sagittal, cine MR images of healthy livers during free breathing. Using the locations of the vessels at each time point, the target position at which the ultrasound focus was to be placed was estimated. In the volunteer experiments (N = 2), the lower limit of the spatial matrix dimension for delineating the veins was 128 x 128. The average displacement of the liver was 19.6 +/- 3.6 mm in superior-inferior (SI) direction and 3.1 +/- 1.4 mm in anterior-posterior (AP) direction. The deformations were 3.7 +/- 1.1 mm in SI direction and 3.0 +/- 1.2 mm in AP direction. The error between the actual and the estimated target point was 0.7 +/- 0.5 mm in SI direction, 0.6 +/- 0.4 mm in AP direction and 1.0 +/- 0.5 mm in distance, and less than 2.1 mm in all the trials. These results suggested that the proposed technique is sufficient for targeting the focus on a specific tissue location and for tracking the slice slab for thermometry to cover the region of focus.
IEEE, 2007年, 2007 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-16, 2614 - 2617, 英語[査読有り]
研究論文(国際会議プロシーディングス)
The purpose of this work is to develop a magnetic resonance (MR) technique for guiding a focal point created in Focused Ultrasound Surgery (FUS) onto a specific target position in an abdominal organ, such as the liver, which moves and deforms with respiratory motion. The translational distance, rotational angles, and amount of expansion and contraction of the organ tissue were measured by obtaining the gravity points of the veins filtered from the sagittal, cine MR images of healthy livers during free breathing. Using the locations of the vessels at each time point, the target position at which the ultrasound focus was to be placed was estimated. In the volunteer experiments (N = 2), the lower limit of the spatial matrix dimension for delineating the veins was 128 x 128. The average displacement of the liver was 19.6 ±3.6 mm in superior-inferior (SI) direction and 3.1 ±1.4 mm in anterior-posterior (AP) direction. The deformations were 3.7 ± 1.1 mm in SI direction and 3.0 ±1.2 mm in AP direction. The error between the actual and the estimated target point was 0.7 ± 0.5 mm in SI direction, 0.6 ±0.4 mm in AP direction and 1.0 ± 0.5 mm in distance, and less than 2.1 mm in all the trials. These results suggested that the proposed technique is sufficient for targeting the focus on a specific tissue location and for tracking the slice slab for thermometry to cover the region of focus. © 2007 IEEE.
2007年, Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, 2614 - 2617, 英語[査読有り]
研究論文(国際会議プロシーディングス)
高等学校「情報」を履修した学生が大学入学の学齢になることに伴い,大学における一般情報教育のあり方が議論されている.本研究では,とくに旧学習指導要領の教育課程の最終年度に,関西地区のある国立大学に入学した学部生2681人を対象に,情報教育の内容に関して,最初の学習機会はどのような形で持たれたかを調査した.この回答データを,学生の出身高校の学校経営形態による相違点に焦点をあてて分析した.その結果,基本的な操作技能以外の多くは未習のまま入学してきた学生が多く,学ばれていた場合でも,その最初は独学で学習することが,とくに私立学校出身者に多くみられた.したがって,当分の間は,基本的な操作技能以外に関しては十分学習可能な機会を提供する必要がある.また,私立学校出身者が多い場合には,独学で学習してきた学生に対し,その理解が適当かどうかを確認する体制も必要である.
日本教育工学会, 2006年12月20日, 日本教育工学会論文誌, 30 (3), 259 - 267, 日本語高等学校「情報」を履修した学生が大学入学の学齢になることに伴い,大学における一般情報教育のあり方が議論されている.本研究では,とくに旧学習指導要領の教育課程の最終年度に,関西地区のある国立大学に入学した学部生2681人を対象に,情報教育の内容に関して,最初の学習機会はどのような形で持たれたかを調査した.この回答データを,学生の出身高校の学校経営形態による相違点に焦点をあてて分析した.その結果,基本的な操作技能以外の多くは未習のまま入学してきた学生が多く,学ばれていた場合でも,その最初は独学で学習することが,とくに私立学校出身者に多くみられた.したがって,当分の間は,基本的な操作技能以外に関しては十分学習可能な機会を提供する必要がある.また,私立学校出身者が多い場合には,独学で学習してきた学生に対し,その理解が適当かどうかを確認する体制も必要である.
日本教育工学会, 2006年12月, 日本教育工学会論文誌, 30 (3), 259 - 267, 日本語[査読有り]
研究論文(学術雑誌)
Referenceless, or self-reference, thermometry is a technique for mapping temperature differences in the region of interest (ROI) using the baseline phase estimated by extrapolating the field in the surrounding region for estimation (RFE) and subtracting the estimated baseline from the measured field. In the present work a self-reference technique based on complex field estimation using 2D polynomials comprising complex-valued coefficients was proposed and optimized. Numerical simulations with a Gaussian-profiled phase distribution demonstrated that the ROI radius had to be 2.3-2.5 times the standard deviation (SD) of the Gaussian function in order to keep the error below 8% of the peak phase change. The area ratio between the ROI and the RFE had to be larger than 2.0 to maintain the error level. Based on the simulations, and phantom and volunteer experiments, the complex-based method with independently optimized polynomial orders for the two spatial dimensions was compared with the phase-based method using the similar-order optimization strategy. The complex-based method appeared to be useful when phase unwrapping was not removed. Otherwise, the phase-based method yielded equivalent results with less polynomial orders.
JOHN WILEY & SONS INC, 2006年10月, MAGNETIC RESONANCE IN MEDICINE, 56 (4), 835 - 843, 英語[査読有り]
研究論文(学術雑誌)
Referenceless, or self-reference, thermometry is a technique for mapping temperature differences in the region of interest (ROI) using the baseline phase estimated by extrapolating the field in the surrounding region for estimation (RFE) and subtracting the estimated baseline from the measured field. In the present work a self-reference technique based on complex field estimation using 2D polynomials comprising complex-valued coefficients was proposed and optimized. Numerical simulations with a Gaussian-profiled phase distribution demonstrated that the ROI radius had to be 2.3-2.5 times the standard deviation (SD) of the Gaussian function in order to keep the error below 8% of the peak phase change. The area ratio between the ROI and the RFE had to be larger than 2.0 to maintain the error level. Based on the simulations, and phantom and volunteer experiments, the complex-based method with independently optimized polynomial orders for the two spatial dimensions was compared with the phase-based method using the similar-order optimization strategy. The complex-based method appeared to be useful when phase unwrapping was not removed. Otherwise, the phase-based method yielded equivalent results with less polynomial orders.
JOHN WILEY & SONS INC, 2006年10月, MAGNETIC RESONANCE IN MEDICINE, 56 (4), 835 - 843, 英語[査読有り]
研究論文(学術雑誌)
Referenceless, or self-reference, thermometry is a technique for mapping temperature differences in the region of interest (ROI) using the baseline phase estimated by extrapolating the field in the surrounding region for estimation (RFE) and subtracting the estimated baseline from the measured field. In the present work a self-reference technique based on complex field estimation using 2D polynomials comprising complex-valued coefficients was proposed and optimized. Numerical simulations with a Gaussian-profiled phase distribution demonstrated that the ROI radius had to be 2.3-2.5 times the standard deviation (SD) of the Gaussian function in order to keep the error below 8% of the peak phase change. The area ratio between the ROI and the RFE had to be larger than 2.0 to maintain the error level. Based on the simulations, and phantom and volunteer experiments, the complex-based method with independently optimized polynomial orders for the two spatial dimensions was compared with the phase-based method using the similar-order optimization strategy. The complex-based method appeared to be useful when phase unwrapping was not removed. Otherwise, the phase-based method yielded equivalent results with less polynomial orders.
JOHN WILEY & SONS INC, 2006年10月, MAGNETIC RESONANCE IN MEDICINE, 56 (4), 835 - 843, 英語[査読有り]
研究論文(学術雑誌)
Referenceless, or self-reference, thermometry is a technique for mapping temperature differences in the region of interest (ROI) using the baseline phase estimated by extrapolating the field in the surrounding region for estimation (RFE) and subtracting the estimated baseline from the measured field. In the present work a self-reference technique based on complex field estimation using 2D polynomials comprising complex-valued coefficients was proposed and optimized. Numerical simulations with a Gaussian-profiled phase distribution demonstrated that the ROI radius had to be 2.3-2.5 times the standard deviation (SD) of the Gaussian function in order to keep the error below 8% of the peak phase change. The area ratio between the ROI and the RFE had to be larger than 2.0 to maintain the error level. Based on the simulations, and phantom and volunteer experiments, the complex-based method with independently optimized polynomial orders for the two spatial dimensions was compared with the phase-based method using the similar-order optimization strategy. The complex-based method appeared to be useful when phase unwrapping was not removed. Otherwise, the phase-based method yielded equivalent results with less polynomial orders.
JOHN WILEY & SONS INC, 2006年10月, MAGNETIC RESONANCE IN MEDICINE, 56 (4), 835 - 843, 英語[査読有り]
研究論文(学術雑誌)
Our challenge was to design and implement a dedicated temperature imaging feedback control system to guide and assist in a thermal liver ablation procedure in a double-donut 0.5T open MR scanner. This system has near-real-time feedback capability based on a newly developed "self-referenced" temperature imaging method using "moving-slab" and complex-field-fitting techniques. Two phantom validation studies and one ex vivo experiment were performed to compare the newly developed self-referenced method with the conventional subtraction method and evaluate the ability of the feedback control system in the same MR scanner. The near-real-time feedback system was achieved by integrating the following primary functions: (1) imaging of the moving organ temperature; (2) on-line needle tip tracking; (3) automatic turn-on/off the heating devices; (4) a Windows operating system-based novel user-interfaces. In the first part of the validation studies, microwave heating was applied in an agar phantom using a fast spoiled gradient recalled echo in a steady state sequence. In the second part of the validation and ex vivo study, target visualization, treatment planning and monitoring, and temperature and thermal dose visualization with the graphical user interface of the thermal ablation software were demonstrated. Furthermore, MR imaging with the "self-referenced" temperature imaging method has the ability to localize the hot spot in the heated region and measure temperature elevation during the experiment. In conclusion, we have demonstrated an interactively controllable feedback control system that offers a new method for the guidance of liver thermal ablation procedures, as well as improving the ability to assist ablation procedures in an open MR scanner. (c) 2006 Elsevier Ireland Ltd. All fights reserved.
ELSEVIER IRELAND LTD, 2006年08月, EUROPEAN JOURNAL OF RADIOLOGY, 59 (2), 175 - 182, 英語[査読有り]
研究論文(学術雑誌)
Our challenge was to design and implement a dedicated temperature imaging feedback control system to guide and assist in a thermal liver ablation procedure in a double-donut 0.5T open MR scanner. This system has near-real-time feedback capability based on a newly developed "self-referenced" temperature imaging method using "moving-slab" and complex-field-fitting techniques. Two phantom validation studies and one ex vivo experiment were performed to compare the newly developed self-referenced method with the conventional subtraction method and evaluate the ability of the feedback control system in the same MR scanner. The near-real-time feedback system was achieved by integrating the following primary functions: (1) imaging of the moving organ temperature; (2) on-line needle tip tracking; (3) automatic turn-on/off the heating devices; (4) a Windows operating system-based novel user-interfaces. In the first part of the validation studies, microwave heating was applied in an agar phantom using a fast spoiled gradient recalled echo in a steady state sequence. In the second part of the validation and ex vivo study, target visualization, treatment planning and monitoring, and temperature and thermal dose visualization with the graphical user interface of the thermal ablation software were demonstrated. Furthermore, MR imaging with the "self-referenced" temperature imaging method has the ability to localize the hot spot in the heated region and measure temperature elevation during the experiment. In conclusion, we have demonstrated an interactively controllable feedback control system that offers a new method for the guidance of liver thermal ablation procedures, as well as improving the ability to assist ablation procedures in an open MR scanner. (c) 2006 Elsevier Ireland Ltd. All fights reserved.
ELSEVIER IRELAND LTD, 2006年08月, EUROPEAN JOURNAL OF RADIOLOGY, 59 (2), 175 - 182, 英語[査読有り]
研究論文(学術雑誌)
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研究論文(国際会議プロシーディングス)
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研究論文(国際会議プロシーディングス)
The self-reference method is a magnetic resonance (MR) thermometry method for mapping temperature changes in a target organ using the baseline phase field in a region of interest (ROI) estimated by the polynomial extrapolation of the field in the surrounding region (s) for estimating (RFE) and subtracting the baseline from the measured field. In the present work, optimization of the ROI and RFE to adopt this technique to MR-guided focused ultrasound surgery (MRgFUS) of uterine fibroid was examined. Both numerical simulation with the Gaussian-profiled heating region and application to clinic...
社団法人日本生体医工学会, 2005年12月10日, 生体医工学 : 日本エム・イー学会誌, 43 (4), 585 - 594, 日本語Application of the self-referenced method of magnetic resonance (MR) thermometry to focused ultrasound surgery (FUS) was examined. The temperature elevation values obtained by the technique in uterine fibroid treatments differed only for 2.99 ± 1.73°C from those by the conventional method when it was worse case in coronal slice, demonstrating usefulness and viability of the technique. © 2005 SICE.
2005年08月, Proc. SICE Annual Meeting 2005 in Okayama, 922 - 927, 英語[査読有り]
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Magnetic resonance imaging (MRI) is known to be the only modality for non-invasive imaging of internal organ temperature under thermal therapies. The thermal change in the phase evolution of the macroscopic magnetization vector has been obtained as the temperature indicator in the conventional method by subtracting the phase at each voxel before heating from that after heating. In the moving organ such as liver, however, the voxel-by-voxel phase subtraction process becomes problematic because of the change in the tissue position and the magnetic flux. To overcome this problem, we have proposed a "self-referenced" method, in which the reference phase value without thermal change is estimated based on the spatial continuity of the phase distribution around the treated tissue region. Our preliminary experimental results in this work demonstrated that the method is effective and viable for imaging liver temperature in vivo.
東海大学, 2003年, Proceedings of the School of Engineering of Tokai University, 28, 63 - 68, 英語[査読有り]
研究論文(学術雑誌)
[査読有り]
研究論文(国際会議プロシーディングス)
The reconstruction of three dimensional structure of cerebral arteries from two dimensional cineangiograms is useful to extract three dimensional information in the angiograms. In this paper, we consider the extraction of vessel center lines from the cineangiograms, which is a basic and important process for the three dimensional reconstruction. As the structure of cerebral arteries is extremely complicated and the vessel regions on the cineangiograms cross and overlap with each other, it is difficult to extract vessel center lines. A framewise extraction method is developed in this study, which repeats the vessel extraction upon each of a series of cineangiograms. On each frame, the system selects a proper image processing algorithm and parameters for the vessels under processing. The extraction method combines both the edge detection and the segmentation to improve the accuracy of vessel extraction from a single frame of cineangiograms. A vessel examining process is also proposed, which evaluates the possibility of extracted center lines being real cerebral arteries. The knowledge about cerebral arteries as well as that of cineangiograms is utilized in the processes for vessel extraction and vessel examination to improve the accuracy of the extraction results. © 1993, Japanese Society for Medical and Biological Engineering. All rights reserved.
1993年, Japanese journal of medical electronics and biological engineering, 31 (1), 37 - 46, 英語[査読有り]
研究論文(学術雑誌)
国の特別天然記念物である阿寒湖のマリモは減少傾向にあり,生長や球化,維持機構に関する知見の集積が急務となっている.本論文では,マリモの挙動に個別要素法(DEM)を適用し,DEMにおける弾性係数𝑘と粘性係数𝛼を室内実験によって推定した.その結果,マリモの大きさや密度に関係なく,𝑘と𝛼を統一できる可能性が示された.また,水中での非破壊検査が可能な磁気共鳴画像法(Magnetic Resonance Imaging:MRI)を用いて,マリモの基部の位置関係と糸状体の伸長生長方向を確認した.代表スケール2cmから8cmまでのサイズのマリモを対象としたMR計測の結果から,糸状体が基部から生長し,マリモが生長するにつれて基部が外縁から中心に移動する傾向が確認された.
公益社団法人 土木学会, 2020年, 土木学会論文集B1(水工学), 76 (2), I_1267 - I_1272, 日本語会議報告等
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速報,短報,研究ノート等(学術雑誌)
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研究発表ペーパー・要旨(国際会議)
In the external beam radiotherapy, it is required to optimize the number of beams, the beam angles, and the strength of irradiation, which deliver the lethal dose to the tumor while limiting the dose absorbed in the normal tissue with fewer beams. In this study, we formulate this problem as a multiobjective linear programming, and propose a planning method to balance the dose distribution and the number of beams by using satisficing trade-off method. An aspiration level to each concerning point specifies the planner's direction for each objective. Therefore, we applied cluster analysis to classify the objective functions, enabling the planner to set up aspiration levels for clusters rather than each objective, which significantly ease the planning task. An illustrated plan of a treatment for cerebral tumor is given to demonstrate the effectiveness of the proposed method.
一般社団法人 システム制御情報学会, 1999年02月15日, システム制御情報学会論文誌, 12 (2), 127 - 135, 日本語In the external beam radiotherapy treatment of cancer, it is important to plan the treatment so that the irradiated energy the tumor is sufficiently high while the dose level at the normal tissue is made as small as possible. In planning a treatment with multiple beams, it is necessary to optimize the position and the intensity of the sources of radiation. In this study, we proposed a treatment planning method by using Mixed Integer Programming (MIP), which can control the number of beams, comsidering the operational feature of the treatment. The effectiveness of the proposed method is demonstrated by an illustrative case study.
一般社団法人 システム制御情報学会, 1996年07月15日, システム制御情報学会論文誌, 9 (7), 329 - 336, 日本語X-ray Computerliged tomography (CT) and nuclear magnetic resonance (NMR) - CT images are usually obtained as a series of two -dimensional images. We have to reconstruct the three -dimensional shapes from those cross sectional images. Surface models as well as solid models are used to represent the three dimensional images. This paper proposed a triangulation algorithm based on some criteria by using the directed graph theory together with dynamic programming (DP) to reconstruct the three -dimensional surface model. Some simple examples according to the minimum surface criterion showed that ...
神戸大学, 1995年, 神戸大学医学部保健学科紀要, 11 (0), 23 - 29, 日本語In the external beam radiotherapy, it is required to optimize the number of beams, the beam angles and the strength of irradiation which deliver the desired dose to the tumour while limiting the dose absorbed in the normal tissue. Mathematical programming techniques are reported to be useful to solve this optimization problem with various types of formulation. In this study, we formulate this problem as a Linear Programming (LP) problem minimizing the mean dose in a buffer region, which is a region located around the tumour to ensure the effectiveness of the solution and the availability of the feasible solution. An illustrative plan of a treatment of cerebral tumour is given to demonstrate the effectiveness of the proposed method. © 1995, Japanese Society for Medical and Biological Engineering. All rights reserved.
日本エム・イー学会, 1995年, 医用電子と生体工学 : 日本ME学会雑誌 = Japanese journal of medical electronics and biological engineering : JJME, 33 (4), 301 - 309, 英語ポスター発表
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公開講演,セミナー,チュートリアル,講習,講義等
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競争的資金
競争的資金
競争的資金
競争的資金
本研究はこれまで比較的動きの少ない臓器に適用されてきた磁気共鳴画像化法(Magnetic Resonance Imaging, MRI)を組み合わせた集束超音波治療(Focused Ultrasound Surgery, FUS)の適用範囲を広げ,より有用な治療法としていくため,臓器の三次元的な呼吸性移動・変形に追従して集束超音波の照射位置を追尾,さらには照射位置の予測による集束超音波の照射制御手法の確立を目指すものである.今年度は特に以下の点について,検討を行った.(1)肝臓の三次元的呼吸性移動・変形の解明呼吸による肝臓の三次元的な移動・変形のパターンを抽出するために,高速撮像法であるFIESTAを用いて,健常ボランティアの肝臓を三次元撮像した.撮像は最大吸気,最大呼気およびその中間での息止めによるマルチスライス画像を取得し,肝臓の血管の三次元再構成を行い,構造解析を行って樹状構造を構築した.さらに,1周期あたり20秒程度のゆっくりとした呼吸で,1呼吸サイクルで10セット程度のマルチスライスを取得し,横隔膜の位置
競争的資金
アスベスト肺とそれに伴う中皮腫の自動診断システムを開発した。アスベスト肺と中皮腫の高い精度での診断はかなり困難であるが、X線ヘリカルCTを用いた3次元画像情報を基に自動診断システムを作り、放射線科医や呼吸器内科医の診断の支援システムを作成した。システムについて精度を測定するためにROC解析を行い、統計的に明らかに精度が向上することが証明された。
競争的資金
肝臓のように呼吸によって動く腹腔臓器に対する集束超音波治療とその際の非侵襲温度モニタリングを行なうために磁気共鳴画像化(MRI)を用いた方法を検討した. 肝臓門脈の断面像の変位から肝組織の動き・変形を実測し, 加温目標点を追尾する方法を提案した.複素磁気共鳴信号の位相から温度分布を求める際の, 画像引き算過程を排除した方法(自己参照法)と組み合わせ, 肝のMRIガイド下集束超音波治療の要素技術を確立した
競争的資金
MR撮像に用いられる傾斜磁場がMR装置内でほぼ線形に変化することに着目し, 治療デバイス先端に傾斜磁場による磁束の変化をとらえるコイルを配置して, リアルタイムで治療デバイスの位置・姿勢を測定するシステム, また治療デバイス先端にMR画像で高輝度となるマーカを取り付け, 多方向からのプロジェクションデータを解析することによりデバイスの位置・姿勢を検出するシステムを提案した。更に, MR装置と内視鏡を融合させたMR-内視鏡システムにおいて, これらの位置姿勢検出システムから得られた情報をもとに, 内視鏡の光学像とMR画像の重畳表示を行った.
競争的資金
本研究は,e-ビジネス環境下において実務的・戦略的に利用可能な意思決定支援システムとして,分散シミュレーション技術を活用した分散型バーチャルファクトリを位置づけ,基本的必要機能の充実を図るとともに,その戦略的意思決定への適用について検討し,下記の成果を得た.1.分散型バーチャルファクトリ(Distributed Virtual Factory, DVF)の構築環境の整備(1)市販シミュレーションシステムを用いて構築された工場シミュレータを統合し,DVFとして機能させるために必要な同期機構・通信インターフェースの開発し,DVF構築の基盤を整備した.(2)離散型製品生産工場,連続製品生産工場のモデル化を行い,開発した基盤の有用性を検証した.(3)モデル工場の生産管理システムとして市販ソフトウエアの組み込みを行い,MRP, APS等の生産管理法を評価出来る体制を整えるとともに,他の市販ソフトウエア導入に関する知見を得た.(4)リアルシステムとバーチャルシステムが連動し,生産システムの運用を効率的に行
競争的資金
競争的資金
近年のダイナミックな需要変動に対応し,厳しい企業間競争に生き残るために,製造業は市場の要求に迅速に応えることのできる生産体制を整備することが不可欠となっている.このため,製造品種の多様性ばかりでなく,その量的変動にも効率的に追従できるアジリティに富む変種変量生産システムを構築するとともに,状況に順応しながら効率的運用を可能とする方法を組み込むことが重要である.本研究では,アジャイル生産に対応可能なシステムとして,工具と加工プログラムの変更により多様な加工プロセスを実行可能なマシニングセンター(MC)を多数配置した機械加工システムを考える.MC群の初期配置としては矩形配置レイアウトを考えるが,さらに設備レイアウトを自己組織的に形成し,自律的に運用する方法について研究し,その有用性を検証することを目的とした.ここでは各MCの加工品種,加工プロセスは事前に固定的に設定するのではなく,システムの運用中にダイナミックに生ずる需要変
競争的資金
本研究では,まず,バーチャル・エンタプライズ(VE)について基礎的検討を行い,一つの製品を製造販売するサプライチェーン(SC)においてメンバーシップを獲得することによりVEが形成されると考えた.さらに,多様な活動主体がメンバーシップを獲得するために,どのような情報や提案を提示するべきか,またそれらに基づいてどのようにして相手を選択すべきかについて検討し,その合意形成の過程について考究し,以下のような二つの観点にたつモデルを考えた.(1)合意形成過程を製品の販売側から上流に向かって順にメンバーを確定(2)SC全体に対して強い力を有するリーダーを考え,その元でSCを形成するさらに,上記の(1)のモデルについて,さらに検討を進め,以下のような成果を得た.1.バーチャルエンタプライズの合意形成プロセスモデルの構築企業間の合意形成過程を製品の販売側から上流に向かって順にメンバーを確定していく上記(1)の形でモデルの構築を行った.各企業をエージェントとしてと
競争的資金
アジャイル・マニュファクチャリングは,多様化,個性化する製品に対する顧客の要求に迅速に応えるための次世代の生産体制を規定する新しい概念として注目されている.本研究では,アジャイル生産に適合した大容量生産システムについて,自動車産業における量産設備の代替,補完性に焦点を絞り研究を進めた.特に,そのシステム構成ばかりでなく,運用法についても検討し,その特性を明らかにした.さらに,従来型の他の生産システムとの経済性についても比較検討し,その有用性について考察した.平成9年度,平成10年度の研究成果は以下の通りである.1. 変種変量生産機能としてのアジャイル性について考察し,それに適合するシステムとして高速・大容量FMSを開発目標と設定した.2. 高速・大容量FMSのシステム構造として機械群の並列・直列型配置を提案した.さらに,その性能評価のためにシミュレーションシステムを構築した.3. 変種変量生産システムとしてHV-FMSとFTLを取り上げ経済性評価モデル
競争的資金
本研究では,多様化,個性化する製品に対する顧客の要求に迅速に応えるための次世代の生産体制であるアジャイル生産に適合した大容量,高速のFMS(HV-FMS)を構築するために必要なシステム設計と運用の方法論について研究することを目的とした.なお,基礎研究として,自動車産業における量産設備の代替,補完性に焦点を絞り,以下の成果を得た.まず,自動車産業における量産機能としてのアジャイル性に関する基礎的考察を行い,大容量FMSの位置づけとそれに要求される基本機能について検討した.TL,FTLは計画生産能力の生産時に最高性能を発揮するが,現実の生産においては計画能力に対する生産量に過不足を生じる.また,新機種の立ち上げ時,旧機種の少量生産への対応などにも問題がある.従って,大容量FMSを以上のような問題に対する解決法の一つとして位置づけることとした.大容量・高速FMSの基本構成として,工程集約型の高速マシニングセンターを要素機械とするフレキシブルな生産システム
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本研究は,工場における生産活動を「仮想生産システム」と呼ぶコンピュータの内部モデルとして表現することを試み,CIM環境下における意思決定をシミュレーション的に支援する機構を整備することを目的としている.特に,今後工場内において分散型情報ネットワークが構築されること,大規模シミュレーションにおける応答の高速性を実現するために分散処理を行うことが効果的であると考えられること,意思決定組織の分散性をモデル化するためには自律性を持つ分散システムの構築が必要であること等の特徴を考慮にいれて,自律分散型仮想生産システムを分散型シミュレーション・システムとして実現することを試みた.生産活動モデルとしての基本的要求事項を整理し,柔軟な仮想生産システムを構築しうる要求仕様を策定した.また,既存のシミュレーションソフトウェアについて調査し,本研究に対する表現機能や適用可能性から検討した.特に,分散型シミュレーション・システムとして
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平成3年度の研究をさらに発展させると共に,その成果を基礎として,以下の研究を推進し,成果を得た.1.分散型シミュレーション・システムの実験環境の整備 分散型シミュレーションに関する技術的問題とその解決法について実験的に考察するため,本研究で導入した機器を用いて分散型情報処理環境を構築し,様々なシミュレーション・システムを評価しうる環境を整えた.2.分散型シミュレーションのための同期法の検討 分散型シミュレーション・システムを構築するためには,システムを構成する各計算機の遂行するシミュレーションの進行を調整し,同期をとることが必要である.従来から提案されている同期法の適用可能性の検討を行うとともに,大規模な生産システムを取り扱うのに適した同期法について検討し,シミュレーション・システムの開発を行った.3.CIM環境を想定した実験的仮想生産システムの試作 CIMの計画段階及び運用段階における分散型シミュレーションの使用について考察
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生産時点情報管理(Point Of Production)は,コンピュータ統合生産(CIM)システムを効率的に運用するために重要である.より高い生産性を実現するためには,POPシステムによって得られるリアルタイム性の高い,精密な情報の利用法と,その評価法について検討を行うことが必要となる.本研究では,それらに対して次のような成果を得た.・日程計画やスケジューリングは,生産性に大きく影響する.スケジューリングに対して,POP情報の最も有効な使用法として考えられることは,工場現場の状況と計画のずれをリアルタイム的に検知し,計画に修正を加え,その新しい計画を即座に現場に伝達するというリスケジューリング機能への適用である.本研究では,POP情報を得られることを前提とした,リスケジューリングの実行タイミングの具体的な決定法を開発し,その有効性をシミュレーションにより示した.・CIMのようなシステムを評価するためには,工場内の生産性だけでなく,経済性等の面から総合的に評価する必
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ジエチレントリアミンペンタ酢酸錯体ポリマー組成物
特願2004-052208, 2004年02月26日, バンドー化学株式会社, 財団法人先端医療振興財団, 特開2005-239641, 2005年09月08日特許権
文字・図形描画装置
特願平2-203984, 1990年08月02日, 富士ゼロックス株式会社, 特開平4-090595, 1992年03月24日, 特許第3018426号, 2000年01月07日特許権
文字・図形描画装置
特願平2-223498, 1990年08月24日, 富士ゼロックス株式会社, 特開平4-104296, 1992年04月06日, 特許第2726951号, 1997年12月12日特許権