研究者紹介システム

川口 芙岐
カワグチ フキ
大学院農学研究科 資源生命科学専攻
助教
Last Updated :2021/05/12

研究者情報

所属

  • 【主配置】

    大学院農学研究科 資源生命科学専攻
  • 【配置】

    農学部 資源生命科学科

学位

  • 博士(農学), 神戸大学

研究活動

受賞

  • 2018年03月 日本畜産学会, 優秀発表賞, ウシ全ゲノムリシーケンスデータを用いたオレイン酸含有率に対する責任変異の探索

    川口芙岐, 木越洸利, 小浜菜美子, 秋山敬孝, 福島護之, 吉田恵実, 小林栄治, 大山憲二, 万年英之, 笹崎晋史

  • 2016年11月 日本動物遺伝育種学会, 学会長特別賞, 黒毛和種繁殖雌牛集団におけるレプチン遺伝子内多型と繁殖形質との関連

    川口芙岐, 深澤謙治, 小浜菜美子, 秋山敬孝, 福島護之, 小林栄治, 大山憲二, 万年英之, 笹崎晋史

論文

  • Cattle mitogenome variation reveals a post-glacial expansion of haplogroup P and an early incorporation into northeast Asian domestic herds

    Hideyuki Mannen, Takahiro Yonezawa, Kako Murata, Aoi Noda, Fuki Kawaguchi, Shinji Sasazaki, Anna Olivieri, Alessandro Achilli, Antonio Torroni

    2020年11月, Scientific Reports, 10 (1), 20842

    [査読有り]

  • Indonesian native goats (Capra hircus) reveal highest genetic frequency of mitochondrial DNA haplogroup B in the world

    Hideyuki Mannen, Kenta Iso, Fuki Kawaguchi, Shinji Sasazaki, Takahiro Yonezawa, Muhammad Ihsan, Andi Dagong, Sri Rachma Aprilita Bugiwati

    2020年09月, Animal Science Journal, 91 (1), e13485

    [査読有り]

  • Fuki Kawaguchi, Miyako Tsuchimura, Kenji Oyama, Tamako Matsuhashi, Shin Maruyama, Hideyuki Mannen, Shinji Sasazaki

    Abstract. Carcass traits have been efficiently improved by recent selection using DNA markers in beef cattle. Additionally, DNA markers might have an effect on other traits such as fertility traits; therefore attention should also be paid to such pleiotropic effects. However, the effects of the markers on both carcass and fertility traits have never been evaluated in the same population, since they are generally measured in different populations. The objective in the current study was to discuss effectiveness of DNA markers developed for carcass traits through investigation of their effects on carcass and fertility traits in a population. We genotyped six markers SCD V293A, FASN g.841G>C, PLAG1 g.49066C>G, NCAPG I442M, DGAT1 K232A, and EDG1 g.1471620G>T in a Japanese Black cattle population (n=515). To investigate their effects on carcass and fertility traits, we performed statistical analysis (ANOVA and the Tukey–Kramer honestly significant difference (HSD) test). In the results, three of six markers, SCD V293A, NCAPG I442M, and EGD1 g.1471620G>T, were significantly associated with both carcass and fertility traits. Remarkably, the same allele for each marker had positive effects on both traits, suggesting that we would be able to simultaneously improve them using these markers in this population. However, previous studies reported that the effects of DNA markers could differ among populations. Therefore, it is necessary to confirm the effect of the marker in each population before it is used for improvement.

    Copernicus GmbH, 2020年01月13日, Archives Animal Breeding, 63 (1), 9 - 17, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Shinji Sasazaki, Fuki Kawaguchi, Ayaka Nakajima, Raito Yamamoto, Takayuki Akiyama, Namiko Kohama, Emi Yoshida, Eiji Kobayashi, Takeshi Honda, Kenji Oyama, Hideyuki Mannen

    Wiley, 2020年01月, Animal Science Journal, 91 (1), 英語

    [査読有り]

    研究論文(学術雑誌)

  • Risa Tabata, Fuki Kawaguchi, Shinji Sasazaki, Yoshio Yamamoto, Felix Rakotondraparany, Fanomezana Mihaja Ratsoavina, Takahiro Yonezawa, Hideyuki Mannen

    Zoological Society of Japan, 2019年08月01日, Zoological Science, 36 (4), 294 - 294, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Hirokazu Matsumoto, Fuki Kawaguchi, Shotaro Itoh, Suzuna Yotsu, Kento Fukuda, Kenji Oyama, Hideyuki Mannen, Shinji Sasazaki

    Elsevier BV, 2019年06月, Meta Gene, 20, 100558 - 100558, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Fuki Kawaguchi, Hiroto Kigoshi, Moriyuki Fukushima, Eiji Iwamoto, Eiji Kobayashi, Kenji Oyama, Hideyuki Mannen, Shinji Sasazaki

    Wiley, 2019年04月, Animal Science Journal, 90 (4), 467 - 472, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Risa Tabata, Fuki Kawaguchi, Shinji Sasazaki, Yoshio Yamamoto, Meirat Bakhtin, Polat Kazymbet, Alykhan Meldevekob, Maratbek Z. Suleimenov, Masahide Nishibori, Hideyuki Mannen

    Wiley, 2019年03月, Animal Science Journal, 90 (3), 317 - 322, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Hiroto Kigoshi, Fuki Kawaguchi, Kenji Oyama, Hideyuki Mannen, Shinji Sasazaki

    Japanese Society of Animal Breeding and Genetics, 2019年, The Journal of Animal Genetics, 47 (2), 37 - 45, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Hayate Yamanaka, Kako Murata, Risa Tabata, Fuki Kawaguchi, Shinji Sasazaki, Yoshio Yamamoto, Meirat Bakhtin, Polat Kazymbet, Alykhan Meldevekob, Maratbek Z. Suleimenov, Masahide Nishibori, Hideyuki Mannen

    Wiley, 2019年01月, Animal Science Journal, 90 (1), 29 - 34, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Fuki Kawaguchi, Hiroto Kigoshi, Ayaka Nakajima, Yuta Matsumoto, Yoshinobu Uemoto, Moriyuki Fukushima, Emi Yoshida, Eiji Iwamoto, Takayuki Akiyama, Namiko Kohama, Eiji Kobayashi, Takeshi Honda, Kenji Oyama, Hideyuki Mannen, Shinji Sasazaki

    Wiley, 2018年08月, Animal Science Journal, 89 (8), 1060 - 1066, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Ayaka Nakajima, Fuki Kawaguchi, Yoshinobu Uemoto, Moriyuki Fukushima, Emi Yoshida, Eiji Iwamoto, Takayuki Akiyama, Namiko Kohama, Eiji Kobayashi, Takeshi Honda, Kenji Oyama, Hideyuki Mannen, Shinji Sasazaki

    The objective of this study was to identify genomic regions associated with fat-related traits using a Japanese Black cattle population in Hyogo. From 1836 animals, those with high or low values were selected on the basis of corrected phenotype and then pooled into high and low groups (n = 100 each), respectively. DNA pool-based genome-wide association study (GWAS) was performed using Illumina BovineSNP50 BeadChip v2 with three replicate assays for each pooled sample. GWAS detected that two single nucleotide polymorphisms (SNPs) on BTA7 (ARS-BFGL-NGS-35463 and Hapmap23838-BTA-163815) and one SNP on BTA12 (ARS-BFGL-NGS-2915) significantly affected fat percentage (FAR). The significance of ARS-BFGL-NGS-35463 on BTA7 was confirmed by individual genotyping in all pooled samples. Moreover, association analysis between SNP and FAR in 803 Japanese Black cattle revealed a significant effect of SNP on FAR. Thus, further investigation of these regions is required to identify FAR-associated genes and mutations, which can lead to the development of DNA markers for marker-assisted selection for the genetic improvement of beef quality.

    Blackwell Publishing, 2018年05月01日, Animal Science Journal, 89 (5), 743 - 751, 英語

    [査読有り]

    研究論文(学術雑誌)

  • H. Kigoshi, F. Kawaguchi, R. Yasuzumi, K. Oyama, H. Mannen, S. Sasazaki

    Genetics and Molecular Research, 2018年, Genetics and Molecular Research, 17 (3), 英語

    [査読有り]

    研究論文(学術雑誌)

  • Aoi NODA, Fuki KAWAGUCHI, Shinji SASAZAKI,, Hideyuki MANNEN

    Japanese Society of Animal Breeding and Genetics, 2018年, The Journal of Animal Genetics, 46 (2), 49 - 55, 日本語

    [査読有り]

    研究論文(学術雑誌)

  • Fuki Kawaguchi, Yuto Kitamura, Ryuji Nakajima, Masayoshi Takahashi, Hiroaki Goto, Yuichi Washida, Yoshikazu Yamamoto, Shinji Sasazaki, Hideyuki Mannen

    The objective of this study was to discriminate between original Japanese and Australian Wagyu beef, which is sold in the Singapore markets, using six previously developed DNA markers. To effectively evaluate the six markers for breed identification, the probability of identification as Australian Wagyu beef was calculated based on the estimated allele frequencies using 130 Australian Wagyu individuals. The combined use of six markers would allow the discrimination of Australian Wagyu beef with an estimated probability of 0.776. The probability to discriminate Australian Wagyu from Japanese Wagyu beef was sufficiently high. In addition, Australian Wagyu has maternal mitochondrial DNA of Bos indicus cattle with moderate high frequency of 0.377. The DNA marker system could also be used as a deterrent force against false sales, and contribute to the reduction and prevention of incorrect or falsified labeling of beef.

    Blackwell Publishing, 2018年01月01日, Animal Science Journal, 89 (1), 257 - 258, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Fuki Kawaguchi, Kazuki Okura, Kenji Oyama, Hideyuki Mannen, Shinji Sasazaki

    Previous studies have indicated that some leptin gene polymorphisms were associated with economically important traits in cattle breeds. However, polymorphisms in the leptin gene have not been reported thus far in Japanese Black cattle. Here, we aimed to identify the leptin gene polymorphisms which are associated with carcass traits and fatty acid composition in Japanese Black cattle. We sequenced the full-length coding sequence of leptin gene for eight Japanese Black cattle. Sequence comparison revealed eight single nucleotide polymorphisms (SNPs). Three of these were predicted to cause amino acid substitutions: Y7F, R25C and A80V. Then, we genotyped these SNPs in two populations (JB1 with 560 animals and JB2 with 450 animals) and investigated the effects on the traits. Y7F in JB1 and A80V in JB2 were excluded from statistical analysis because the minor allele frequencies were low (< 0.1). Association analysis revealed that Y7F had a significant effect on the dressed carcass weight in JB2 R25C had a significant effect on C18:0 and C14:1 in JB1 and JB2, respectively and A80V had a significant effect on C16:0, C16:1, C18:1, monounsaturated fatty acid and saturated fatty acid in JB1. The results suggested that these SNPs could be used as an effective marker for the improvement of Japanese Black cattle.

    Blackwell Publishing, 2017年03月01日, Animal Science Journal, 88 (3), 433 - 438, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Fuki KAWAGUCHI, Satoshi KOGA, Kenji OYAMA, Hideyuki MANNEN,, Shinji SASAZAKI

    Japanese Society of Animal Breeding and Genetics, 2017年, 動物遺伝育種研究, 45 (1), 3 - 8, 日本語

    [査読有り]

    研究論文(学術雑誌)

  • Fuki KAWAGUCHI, Kenji FUKAZAWA, Namiko KOHAMA, Takayuki AKIYAMA, Moriyuki FUKUSHIMA, Eiji KOBAYASHI, Kenji OYAMA, Hideyuki MANNEN, Shinji SASAZAKI

    Japanese Society of Animal Science, 2016年, 日本畜産学会報, 87 (4), 333 - 338, 日本語

    [査読有り]

    研究論文(学術雑誌)

講演・口頭発表等

  • 父母系および高密度 SNPマーカーを用いたフィリ ピン在来ヤギの遺伝構造と伝播の推定

    AYIN AYIN, 田端 里彩, 笹崎 晋史, 川口 芙岐, 小林 栄治, 山本 義雄, 米澤 隆弘, 呉 佳齊, Masangkay J, 万年 英之

    日本畜産学会第128回大会, 2021年03月28日

  • 50K SNPアレイを用いた和牛4品種に関する多様性および類縁関係の調査

    中村充暉, 鈴木啓一, 小林栄治, 万年英之, 笹崎晋史, 川口芙岐

    日本畜産学会第128回大会, 2021年03月28日

  • 集積流体回路を用いた兵庫県黒毛和種集団におけるロース脂肪割合候補多型の効果の検証

    近藤陽菜, 小浜菜美子, 秋山敬孝, 吉田恵実, 小林栄治, 川口芙岐, 万年英之, 笹崎晋史

    日本動物遺伝育種学会第21回大会, 2020年11月21日

  • Phylogenetic analysis of Nepalese goats using mtDNA D-loop region and SRY gene sequences

    Nomura Y, Kunieda T, Shah M, Kawaguchi F, Sasazaki S, Mannen H

    37th International Society for Animal Genetics Conference, 2019年07月, 英語

    ポスター発表

  • Genetic diversity of Bos taurus and Bos indicus using developed indel markers. 37th International Society for Animal Genetics Conference

    Yasui T, Yamanaka H, Kawaguchi F, Sasazaki S, Yonezawa T, Wu J, Mannen H

    37th International Society for Animal Genetics Conference, 2019年07月, 英語

    ポスター発表

  • Genetic diversity and structure in 11 native Asian goat populations analyzed by high density SNP array. 37th International Society for Animal Genetics Conference

    Iso K, Sasazaki S, Kawaguchi F, Yonezawa T, Wu J, Nomura K, Takahashi Y, Kobayashi E, Shah M, Faruque O, Masangkay J.S, Bakhtin M, Kazymbet P, Dorji T, Mannen H

    37th International Society for Animal Genetics Conference, 2019年07月, 英語

    ポスター発表

  • Effect of the PLAG1 gene polymorphism on carcass weight and oleic acid percentage in Japanese Black cattle populations

    Fuki KAWAGUCHI, Hiroto KIGOSHI, Riri YASUZUMI, Kenji OYAMA, Hideyuki MANNEN, Shinji SASAZAKI

    37th International Society for Animal Genetics Conference, 2019年07月, 英語

    ポスター発表

  • Molecular epidemiological study of bovine leukemia virus in Zebu cattle (Bos indicus)

    Nishikaku K, Yonezawa T, Murakami S, Torii Y, Kawaguchi F, Sasazaki S, Mannen H, Kobayashi T

    The 2nd Joint Meeting of Veterinary Science in East Asia, 2019年04月

  • アジア在来牛における牛白血病ウイルスの分子疫学的解析

    西角光平, 米澤隆弘, 村上覚史, 鳥居恭司, 川口芙岐, 刘建全, 万年英之, 小林朋子

    第54回獣医疫学会学術集会, 2019年03月

  • mtDNA D-loop領域とSRY遺伝子の塩基配列に基づいたネパール在来ヤギの遺伝的類縁関係

    野村悠登, 国枝哲夫, Manoj Shah, 笹崎晋史, 川口芙岐, 万年英之

    日本畜産学会第125回大会, 2019年03月, 日本語

    口頭発表(一般)

  • 複数の黒毛和種集団を用いたSLC27A6遺伝子多型のBMSに対する効果の検討

    山本雷斗, 川口芙岐, 秋山敬孝, 吉田恵実, 小浜菜美子, 小林栄治, 大山憲二, 万年英之, 笹崎晋史

    日本畜産学会第125回大会, 2019年03月, 日本語

    口頭発表(一般)

  • 兵庫県黒毛和種集団における全ゲノムリシーケンスデータを用いた枝肉形質に対する候補変異の抽出

    木越洸利, 川口芙岐, 大山憲二, 万年英之, 笹崎晋史

    日本動物遺伝育種学会第19回大会, 2018年09月, 日本語

    口頭発表(一般)

  • Detection of candidate polymorphisms in the QTL for oleic acid percentage on BTA9 based on whole-genome resequencing data

    Fuki KAWAGUCHI, Hiroto KIGOSHI, Namiko KOHAMA, Takayuki AKIYAMA, Moriyuki FUKUSHIMA, Emi YOSHIDA, Eiji KOBAYASHI, Kenji OYAMA, Hideyuki MANNEN, Shinji SASAZAKI

    Plant & Animal Genome Asia 2018, 2018年05月, 英語

    ポスター発表

  • ウシ全ゲノムリシーケンスデータを用いたオレイン酸含有率に対する責任変異の探索

    川口芙岐, 木越洸利, 小浜菜美子, 秋山敬孝, 福島護之, 吉田恵実, 小林栄治, 大山憲二, 万年英之, 笹崎晋史

    日本畜産学会第124回大会, 2018年03月, 日本語

    口頭発表(一般)

  • 兵庫県黒毛和種におけるゲノムワイド関連解析により同定されたVNN1遺伝子T66M多型のオレイン酸含有率に対する効果

    木越洸利, 川口芙岐, 上本吉伸, 福島護之, 吉田恵実, 岩本英治, 秋山敬孝, 小浜菜美子, 小林栄治, 大山憲二, 万年英之, 笹崎晋史

    日本動物遺伝育種学会第 18 回年次大会, 2017年11月, 日本語

    口頭発表(一般)

  • 複数の黒毛和種集団を用いたPLAG1遺伝子多型のオレイン酸含有率に対する効果の検討

    川口芙岐, 木越洸利, 安栖梨理, 小浜菜美子, 秋山敬孝, 福島護之, 小林栄治, 大山憲二, 万年英之, 笹崎晋史

    日本動物遺伝育種学会第 18 回年次大会, 2017年11月, 日本語

    口頭発表(一般)

  • Association of VNN1 gene polymorphism with fatty acid composition in Japanese Black cattle

    Kigoshi H, Matsumoto Y, Kawaguchi F, Uemoto Y, Kobayashi E, Fukushima M, Iwamoto E, Yoshida E, Akiyama T, Kohama N, Oyama K, Honda T, Mannen H, Sasazaki S

    36th International Society for Animal Genetics Conference, 2017年07月, 英語

    ポスター発表

  • Effect of DNA markers associated with carcass traits and fatty acid composition on fertility traits in Japanese Black cows

    Tsuchimura M, Fukazawa K, Kawaguchi F, Matsuhashi T, Maruyama S, Oyama K, Sasazaki S, Mannen H

    36th International Society for Animal Genetics Conference, 2017年07月, 英語

    ポスター発表

  • PLAG1 polymorphism (ss319607405) is associated with oleic acid percentage in Japanese Black cattle

    Fuki KAWAGUCHI, Hiroto KIGOSHI, Ayaka NAKAJIMA, Yuta MATSUMOTO, Yoshinobu UEMOTO, Moriyuki FUKUSHIMA, Emi YOSHIDA, Eiji IWAMOTO, Takayuki AKIYAMA, Namiko KOHAMA, Eiji KOBAYASHI, Takeshi HONDA, Kenji OYAMA, Hideyuki MANNEN, Shinji SASAZAKI

    36th International Society for Animal Genetics Conference, 2017年07月, 英語

    ポスター発表

  • 黒毛和種繁殖雌牛集団におけるレプチン遺伝子内多型と繁殖形質との関連

    川口芙岐, 深澤謙治, 小浜菜美子, 秋山敬孝, 福島護之, 小林栄治, 大山憲二, 万年英之, 笹崎晋史

    日本動物遺伝育種学会第 17 回年次大会, 2016年11月, 日本語

    口頭発表(一般)

  • Identification of polymorphisms associated with oleic acid percentage by pool-based genome wide association study (GWAS) in Japanese Black

    Fuki KAWAGUCHI, Ayaka NAKAJIMA, Yuta MATSUMOTO, Yoshinobu UEMOTO, Moriyuki FUKUSHIMA, Emi YOSHIDA, Eiji IWAMOTO, Takayuki AKIYAMA, Namiko KOHAMA, Eiji KOBAYASHI, Takeshi HONDA, Kenji OYAMA, Shinji SASAZAKI, Hideyuki MANNEN

    35th International Society for Animal Genetics Conference, 2016年07月, 英語

    ポスター発表

  • 黒毛和種集団におけるLeptin遺伝子翻訳領域内多型の脂肪酸組成に対する効果

    川口 芙岐, 大倉 一輝, 大山 憲二, 万年 英之, 笹崎 晋史

    日本畜産学会第119回大会, 2015年03月, 日本語

    口頭発表(一般)