研究者紹介システム

長谷川 巧実
ハセガワ タクミ
大学院医学研究科 医科学専攻
講師
医学
Last Updated :2022/08/09

研究者情報

所属

  • 【主配置】

    大学院医学研究科 医科学専攻
  • 【配置】

    医学部 医学科, 医学部附属病院 歯科口腔外科

学位

  • 博士(医学), 神戸大学

授業科目

  • 臨床医学講義3(歯科口腔外科), 医学部 医学科, 2021

ジャンル

  • 医療・健康 / 臨床医学
  • 医療・健康 / がん治療

コメントテーマ

  • 口腔がん
  • インプラント

研究活動

研究分野

  • ライフサイエンス / 外科系歯学

受賞

  • 2018年11月 第63回日本口腔外科学会総会・学術大会, 優秀口演発表賞, 効率的な低酸素環境改善による口腔癌の新規治療法の開発と治療抵抗性の改善効果

    長谷川巧実

    国内学会・会議・シンポジウム等の賞

  • 2007年09月 第37回日本口腔インプラント学会, 学会賞(デンツプライ賞)受賞, β-リン酸三カルシウム(β-TCP)内への骨髄幹細胞(BMSC)導入方法と骨形成能の検討

    長谷川巧実

    国内学会・会議・シンポジウム等の賞

論文

  • Sakiko Soutome, Souichi Yanamoto, Mika Nishii, Yuka Kojima, Takumi Hasegawa, Madoka Funahara, Masaya Akashi, Toshiyuki Saito, Masahiro Umeda

    Background/purpose: Radiotherapy for head and neck cancer often causes severe oral mucositis. The purpose of this retrospective study was to further examine the risk factors for developing severe oral mucositis in patients with oral cancer undergoing radiotherapy as a compliment to a previous study performed by our group. Materials and methods: A total of 181 patients with oral cancer undergoing radiotherapy were enrolled in the study. The association between a number of potential risk factors and grade 3 oral mucositis were analyzed using the cox proportional hazard model and a logistic regression analysis. Results: Grade 3 oral mucositis occurred in 56 patients. The cox proportional hazard model analysis revealed that those with lower hemoglobin levels, concurrent cisplatin and cetuximab administration, and a larger number of teeth showed a significantly higher incidence of severe oral mucositis. Logistic regression analysis revealed that patients who had lower hemoglobin levels, received concurrent cisplatin or cetuximab treatment, and were not administered pilocarpine showed a significantly higher incidence of severe oral mucositis. The presence of teeth may stimulate the oral mucosa and become a risk factor for mucositis, and the administration of pilocarpine might reduce the risk. Conclusion: This study describes the risk factors of severe radiation-induced oral mucositis in oral cancer patients and shows the possibility of risk reduction by pilocarpine. This information could help patients avoid painful mucositis.

    2021年10月, Journal of Dental Sciences, 16 (4), 1241 - 1246

    研究論文(学術雑誌)

  • T Hasegawa, N Ueda, S I Yamada, S Kato, E Iwata, S Hayashida, Y Kojima, M Shinohara, I Tojo, H Nakahara, T Yamaguchi, T Kirita, H Kurita, Y Shibuya, S Soutome, M Akashi

    Pre-existing inflammation, corticosteroid therapy, periapical periodontitis, longer duration of denosumab therapy, and female sex were significantly associated with an increased risk of denosumab-related osteonecrosis of the jaw after tooth extraction in patients with cancer on oncologic doses of denosumab. A short drug holiday did not protect against this complication. INTRODUCTION: This study retrospectively investigated the relationship between various risk factors, including brief discontinuation of denosumab, and development of denosumab-related osteonecrosis of the jaw (DRONJ) after tooth extraction in patients with cancer who were receiving oncologic doses of this agent. METHODS: Data were collected on demographic characteristics, duration of denosumab therapy, whether or not denosumab was discontinued before tooth extraction (drug holiday), duration of discontinuation, presence of pre-existing inflammation, and whether or not additional surgical procedures were performed. Risk factors for DRONJ after tooth extraction were evaluated by univariate and multivariate analyses. RESULTS: A total of 136 dental extractions were performed in 72 patients (31 men, 41 women) with cancer who were receiving oncologic doses of denosumab. Post-extraction DRONJ was diagnosed in 39 teeth (28.7%) in 25 patients. Tooth extraction was significantly associated with development of DRONJ only in patients with pre-existing inflammation (odds ratio [OR] 243.77), those on corticosteroid therapy (OR 73.50), those with periapical periodontitis (OR 14.13), those who had been taking oncologic doses of denosumab for a longer period (OR 4.69), and in women (OR 1.04). There was no significant difference in the occurrence of DRONJ between patients who had a drug holiday before tooth extraction and those who did not. CONCLUSIONS: These findings suggest that inflamed teeth should be extracted immediately in patients with cancer who are receiving oncologic doses of denosumab. Drug holidays have no significant impact on the risk of DRONJ.

    2021年05月17日, Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 英語, 国際誌

    研究論文(学術雑誌)

  • 口腔・中咽頭癌放射線治療326例における重症口腔粘膜炎および口腔カンジダ症発症に関連する因子

    西井 美佳, 五月女 さき子, 岩田 英治, 長谷川 巧実, 兒島 由佳, 船原 まどか, 梅田 正博, 明石 昌也

    (一社)日本口腔ケア学会, 2021年04月, 日本口腔ケア学会雑誌, 15 (3), 145 - 145, 日本語

  • Izumi Saito, Takumi Hasegawa, Yumiko Kawashita, Shinichiro Kato, Shin-Ichi Yamada, Yuka Kojima, Nobuhiro Ueda, Masahiro Umeda, Yasuyuki Shibuya, Hiroshi Kurita, Tadaaki Kirita, Masaya Akashi

    OBJECTIVE: Radiotherapy (RT) carries a substantial risk for the development of osteoradionecrosis (ORN) of the jaw. This study was performed to investigate the relationship between dental extractions after RT and the development of ORN. MATERIAL AND METHODS: Thirty-two patients with head and neck cancer who underwent tooth extraction after RT were investigated for correlations between the development of ORN and various factors. RESULTS: Postextraction ORN was diagnosed in 12 (12.1%) teeth of 9 patients. The RT dose against the site of tooth extraction was 62.0 and 37.4 Gy in the ORN and Non-ORN groups, respectively (p < .001). The duration from RT to tooth extraction was 41.2 and 28.2 months in the ORN and Non-ORN groups, respectively (p = .025). Tooth extraction was significantly associated with ORN in patients with a high RT dose against the site (odds ratio = 1.231) and a longer duration of time from RT (odds ratio = 1.084). CONCLUSIONS: Extraction of non-restorable teeth and those with a poor prognosis should not necessarily be postponed even when patients are undergoing RT. However, clinicians should pay special attention to postoperative management after tooth extraction in patients with a high RT dose and longer time from RT.

    2021年03月01日, Oral diseases, 英語, 国際誌

    研究論文(学術雑誌)

  • Eiji Iwata, Takumi Hasegawa, Masaki Kobayashi, Akira Tachibana, Naoki Takata, Toshiya Oko, Daisuke Takeda, Yoshiki Ishida, Tsuyoshi Fujita, Ikuko Goto, Junichiro Takeuchi, Masaya Akashi

    PURPOSE: In maxillary wisdom tooth extraction, the necessity of CT is unknown. The purpose of this study was to investigate whether CT adding to orthopantomography is useful for predicting oroantral perforation during maxillary third molar extraction. METHODS: Various risk factors for oroantral perforation during maxillary third molar extraction were investigated by univariate and multivariate analyses. We analyzed those of all patients and the patients who underwent CT, respectively. The proximity of the roots to the maxillary sinus floor (root-sinus [RS] classification) and Archer classification were assessed using panoramic radiography. The number of roots and vertical relationship were assessed using CT. RESULTS: A total of 604 out of 3299 patients underwent CT adding to orthopantomography. In all cases, multivariate analyses except for CT findings showed that the RS classification type III/IV and the Archer classification Type B/C/D in panoramic findings were significantly correlated with oroantral perforation as radiological findings. In cases for which CT was performed, multivariate analyses showed that one root (OR 12.87) and the vertical relationship Type D (OR 5.63) in CT findings, besides the RS classification type III/IV (OR 4.47) in panoramic findings, were significantly related to oroantral perforation. CONCLUSION: The RS classification and the Archer classification in panoramic findings can predict the risk of oroantral perforation. The usefulness of CT adding to orthopantomography is limited. However, when the relationship between the upper wisdom tooth and maxillary sinus floor (RS classification) is unclear, to check whether the number of roots is one and the apex of one root is projecting into the maxillary sinus in CT findings, is useful for the prediction.

    2021年03月, Oral and maxillofacial surgery, 25 (1), 7 - 17, 英語, 国際誌

    研究論文(学術雑誌)

  • Takumi Hasegawa, Erina Kobayashi, Rika Amano, Izumi Saito, Daisuke Takeda, Yasumasa Kakei, Akira Kimoto, Akiko Sakakibara, Masaya Akashi

    Purpose Recurrence in oral squamous cell carcinoma (OSCC) is not rare. Due to lack of studies assessing characteristics of recurrent OSCC, including time to recurrence and outcomes, we sought to investigate its characteristics, time to recurrence, and outcomes in Japanese OSCC patients. Methods This study was a nonrandomized retrospective cohort study in a tertiary referral centre. It included 208 (117 men and 91 women) patients with recurrent oral cancer who underwent major curative surgery in the Department of Oral and Maxillofacial Surgery at Kobe University Hospital between January 1999 and April 2017. The outcomes were disease-specific survival (DSS) and overall survival (OS). Results In multivariable Cox proportional hazards analysis, the time to recurrence (hazard ratio [HR] 3.55, 95% confidence interval [CI] 1.69-6.63; P = 0.001), extranodal extension (ENE, HR 2.72, 95% CI 1.51-4.89; P = 0.001), and high T stage (HR 2.00, 95% CI 1.01-3.97; P = 0.046) were independent predictors of DSS. The time to recurrence (HR 3.29, 95% CI 1.82-5.96; P < 0.001) and ENE (HR 2.64, 95% CI 1.52-4.56; P = 0.001) were independent predictors of OS. Conclusion Time to recurrence, extranodal extension, and higher T stage were independent prognosis predictors in OSCC.

    SPRINGER INDIA, 2021年02月, JOURNAL OF MAXILLOFACIAL & ORAL SURGERY, 英語

    研究論文(学術雑誌)

  • Takumi Hasegawa, Nanae Yatagai, Tatsuya Furukawa, Emi Wakui, Izumi Saito, Daisuke Takeda, Yasumasa Kakei, Akiko Sakakibara, Ken-Ichi Nibu, Masaya Akashi

    BACKGROUND: This prospective study investigated the change of swallowing ability using the Swallowing Ability Scale System (SASS) and swallowing-related quality of life (QOL) by Performance Status Scale for Head and Neck Cancer patients (PSS-H&N). This study also investigated the risk factors for postoperative dysphagia in patients who received reconstructive surgery for oral cancer. SUBJECTS AND METHODS: This study included 64 patients (33 men and 31 women) who underwent radical surgery with neck dissection and reconstructive surgery for oral cancers between July 2014 and February 2018. We evaluated risk factors for poor swallowing ability after treatment, including demographic factors, preoperative factors and perioperative factors, with univariate and multivariate analyses. The change of swallowing ability by the SASS and swallowing-related QOL by PSS-H&N were evaluated prospectively prior to the initiation of surgery within 1 week and at 1 and 3 months after treatment. RESULTS: Advanced T stage (T3, 4) (odds ratio (OR) = 79.71), bilateral neck dissection (OR = 20.66) and the resection of unilateral or bilateral suprahyoid muscles (OR = 17.00) were associated with poor swallowing ability after treatment. The scores for time for food intake and Eating in Public were associated with decrease of QOL in the poor group. CONCLUSIONS: We propose that clinicians consider the risk factors identified in this study and pay close attention to the management of oral cancer patients with reconstructive surgery.

    2021年01月25日, Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale, 50 (1), 4 - 4, 英語, 国際誌

    研究論文(学術雑誌)

  • Hikaru Kubota, Daisuke Miyawaki, Naritoshi Mukumoto, Takeaki Ishihara, Megumi Matsumura, Takumi Hasegawa, Masaya Akashi, Naomi Kiyota, Hirotaka Shinomiya, Masanori Teshima, Ken-Ichi Nibu, Ryohei Sasaki

    BACKGROUND: To evaluate factors associated with osteoradionecrosis of the jaw (ORNJ) in patients with head and neck squamous cell carcinoma (HNSCC), focusing on jaw-related dose-volume histogram (DVH) parameters. METHODS: We retrospectively reviewed the medical records of 616 patients with HNSCC treated with curative-intent or postoperative radiation therapy (RT) during 2008-2018. Patient-related (age, sex, history of smoking or alcohol use, diabetes mellitus, performance status, pre-RT dental evaluation, pre- or post-RT tooth extraction), tumor-related (primary tumor site, T-stage, nodal status), and treatment-related (pre-RT surgery, pre-RT mandible surgery, induction or concurrent chemotherapy, RT technique) variables and DVH parameters (relative volumes of the jaw exposed to doses of 10 Gy-70 Gy [V10-70]) were investigated and compared between patients with and without ORNJ. The Mann-Whitney U test was used to compare RT dose parameters. Univariate and multivariate Cox regression analyses were used to assess factors associated with ORNJ development. Kaplan-Meier analyses were performed for cumulative ORNJ incidence estimation. RESULTS: Forty-six patients (7.5%) developed ORNJ. The median follow-up duration was 40 (range 3-145) months. The median time to ORNJ development was 27 (range 2-127) months. DVH analysis revealed that V30-V70 values were significantly higher in patients with than in those without ORNJ. In univariate analyses, primary tumor site, pre-RT mandible surgery, post-RT tooth extraction, and V60 > 14% were identified as important factors. In multivariate analyses, V60 > 14% (p = 0.0065) and primary tumor site (p = 0.0059) remained significant. The 3-year cumulative ORNJ incidence rates were 2.5% and 8.6% in patients with V60 ≤ 14% and > 14%, respectively (p < 0.0001), and 9.3% and 1.4% in patients with oropharyngeal or oral cancer and other cancers, respectively (p < 0.0001). CONCLUSIONS: V60 > 14% and oropharyngeal or oral cancer were found to be independent risk factors for ORNJ. These findings might be useful to minimize ORNJ incidence in HNSCC treated with curative RT.

    2021年01月05日, Radiation oncology (London, England), 16 (1), 1 - 1, 英語, 国際誌

    研究論文(学術雑誌)

  • Ryuichiro Funahara, Sakiko Soutome, Madoka Funahara, Shoma Tsuda, Takumi Hasegawa, Masahiro Umeda, Masaya Akashi

    Purpose: Serious oral mucositis develops during radiation therapy (RT) for head and neck cancer, but there is no effective preventive method. We have used a steroid ointment to prevent oral mucositis during RT, but the use of steroid ointment is discontinued when oral candidiasis develops. Therefore, prevention of oral candidiasis is important. The purpose of this study was to examine whether administration of a miconazole oral patch reduced the amount of Candida albicans in saliva and prevented the development of oral candidiasis during RT. Methods: Participants were patients with head and neck cancer receiving RT ≥ 60 Gy. Patients in the intervention group received miconazole oral patches for 14 days after the appearance of grade 2 oral mucositis. The control group received oral care only. Total bacteria and C. albicans counts in the saliva were analyzed by real-time polymerase chain reaction. The incidence of oral candidiasis was compared between the groups. Results: Total bacterial counts did not change throughout RT in either the intervention or the control group. However, C. albicans count significantly increased at 30 Gy and 60 Gy in the control group but was suppressed in the intervention group. The saliva pH did not show a significant change throughout RT in either group. The incidence of oral candidiasis in the intervention group tended to be lower than that in the control group. Conclusion: This study suggested that prophylactic use of a miconazole oral patch was effective in suppressing the growth of C. albicans count in saliva during RT for head and neck cancer.

    2021年, Supportive Care in Cancer

    研究論文(学術雑誌)

  • Wensu Huang, Masaya Akashi, Takuro Nishio, Noriyuki Negi, Akira Kimoto, Takumi Hasegawa

    INTRODUCTION: Elongated mandibular coronoid process is a rare condition defined as enlargement of the coronoid process. The only useful way to treat the mouth-opening limitation is resection of the elongated coronoid process. Four-dimensional CT (4DCT; three spatial dimensions plus time axis) is a novel imaging technique. Its usefulness of for evaluation of dynamic movements such as joint motion has been reported. Here, we show the potential usefulness of 4DCT evaluation in a patient with elongated mandibular coronoid process. CASE PRESENTATION: A 59-year-old female who suffered from mouth-opening difficulty and pressure during mouth opening was referred to our department. Elongation of the right coronoid process was evident in a panoramic X-ray image. The mandibular movement and temporal muscle motility before and after coronoidectomy in this patient on 4DCT could be evaluated. CONCLUSIONS: 4DCT is useful in the diagnosis and surgical outcome of elongated coronoid process.

    2020年12月, Oral and maxillofacial surgery, 24 (4), 515 - 520, 英語, 国際誌

    研究論文(学術雑誌)

  • Eiji Iwata, Akira Tachibana, Junya Kusumoto, Naoki Takata, Takumi Hasegawa, Masaya Akashi

    BACKGROUND: Various antibiotics and analgesics have been reported to interact with warfarin. Reports that investigate the effects of medication taken for just a few days during tooth extraction on the prothrombin time-international normalized ratio are rare. METHODS: A total of 110 patients receiving long-term stable warfarin therapy underwent tooth extraction without interruption of warfarin treatment. INR values were measured 1 month before the tooth extraction, the day of the extraction, and 1 week after the extraction. We investigated the changes in INR values between the day of extraction and 1 week after extraction, as well as the various risk factors for increases in INR values. RESULTS: Before and after tooth extraction, the number of patients taking cefcapene pivoxil, amoxicillin, and azithromycin was 57, 36, and 8, respectively. Nine patients were administered ampicillin before tooth extraction and received amoxicillin after their tooth extraction. One week after tooth extraction, the INR values increased beyond the therapeutic range in 3 out of 110 patients (2.7%). The INR values before tooth extraction in these three patients were close to 3.0. The INR value increased by more than twice as much in 1 out of 110 patients (0.9%). CONCLUSION: Our results suggest that prophylactic antibiotic administration has little effect on INR values when patients on stable warfarin therapy undergo tooth extraction. Surgeons have to take attention if the patients whose INR values are close to 3.0 before their extraction.

    2020年11月19日, BMC oral health, 20 (1), 331 - 331, 英語, 国際誌

    研究論文(学術雑誌)

  • 延原 浩, 五月女 さき子, 林田 咲, 梅田 正博, 長谷川 巧実, 明石 昌也, 山田 慎一, 栗田 浩, 中原 寛和, 上田 順宏, 桐田 忠昭, 中村 知寿, 渋谷 恭之, 山口 泰平, 森 和代

    (一社)日本外科感染症学会, 2020年10月, 日本外科感染症学会雑誌, 17 (5), 329 - 329, 日本語

  • 延原 浩, 五月女 さき子, 林田 咲, 梅田 正博, 長谷川 巧実, 明石 昌也, 山田 慎一, 栗田 浩, 中原 寛和, 上田 順宏, 桐田 忠昭, 中村 知寿, 渋谷 恭之, 山口 泰平, 森 和代

    (一社)日本外科感染症学会, 2020年10月, 日本外科感染症学会雑誌, 17 (5), 329 - 329, 日本語

  • Ryuichi Itoh, Shin ichi Yamada, Takumi Hasegawa, Nobuhiro Yamakawa, Yuya Denda, Hiroki Otagiri, Masaya Okura, Souichi Yanamoto, Masaya Akashi, Tadaaki Kirita, Yoshihide Ota, Masahiro Umeda, Hiroshi Kurita

    The aim of the present study was to review the treatment outcomes of oral sarcoma in Japan based on a multicenter retrospective analysis. Between January 2001 and December 2015, 30 patients were histologically diagnosed with sarcoma in the oral and maxillofacial regions and retrospectively reviewed. Osteosarcoma was the most common in 6 (20 %) out of 30 cases, followed by 3 cases (10 %) of fibrosarcoma. The average maximum size of the primary tumor was 42.3 ± 18.7 mm (range: 5−80 mm). The mandible was the most common site of the primary tumor and observed in 15 cases (50 %), followed by the maxilla in 12 cases (40 %). Soft tissue sarcoma was noted in 3 cases (10 %). The average follow-up period was 5.6 ± 4.6 years (range, 0.1–14.7 years). Five- and 10-year OS rates were 81.4 and 62.0 %, respectively. Five- and 10-year OS rates in cases that underwent radical surgery were 95.5 and 72.7 %, respectively, and were significantly higher than those treated with non-surgical therapy (p < 0.0001). The early detection and complete surgical resection of primary tumors with adequate surgical margins appears to be important for improving the prognosis of oral sarcoma patients.

    2020年09月, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, 32 (5), 356 - 359

    研究論文(学術雑誌)

  • Shin-Ichi Yamada, Takumi Hasegawa, Sakiko Soutome, Hitoshi Yoshimura, Masaaki Miyakoshi, Nobuhiro Ueda, Kenjiro Okamoto, Sumiyo Hishida, Satoshi Rokutanda, Hirokazu Nakahara, Shigeyuki Fujita, Masaya Akashi, Yoshimasa Kitagawa, Tadaaki Kirita, Yasuyuki Shibuya, Masahiro Umeda, Hiroshi Kurita

    Postoperative hemorrhage after tooth extraction is a critical and clinically important issue for clinicians and patients receiving anticoagulants. The purpose of the present study was to investigate the prevalence of and risk factors for postoperative hemorrhage after lower third molar extraction in Japanese patients receiving warfarin therapy. A total of 142 patients who underwent lower third molar extraction between January 2010 and December 2016 were included, and their medical records were retrospectively reviewed. The prevalence of and risk factors for postoperative hemorrhage were investigated. The prevalence of postoperative hemorrhage after lower third molar extraction was significantly higher in patients receiving warfarin than in healthy subjects (21.8% vs 0.7%, P < 0.001). The cutoff value for PT-INR was 2.11 based on a receiver-operating characteristic analysis. A multivariate analysis indicated that an elevated PT-INR value [hazard ratio (HR) 3.798, 95% confidence interval (CI) 1.400-10.467, P < 0.01], preoperative antibiotic administration (HR 4.434, 95% CI 1.591-14.775, P < 0.01), difficulties with intraoperative hemostasis (HR 16.298, 95% CI 2.986-110.677, P < 0.01), and higher serum creatinine levels (HR 7.465, 95% CI 1.616-39.576, P < 0.05) are significant predictors of postoperative hemorrhage after lower third molar extraction. Multivariate correlations were observed between risk factors including an elevated PT-INR value, preoperative antibiotic administration, and higher serum creatinine levels, and postoperative hemorrhage after lower third molar extraction in patients receiving warfarin therapy. Clinicians need to consider these risk factors for postoperative hemorrhage after the lower third molar extraction and monitor PT-INR in patients receiving warfarin therapy.

    2020年07月, Odontology, 108 (3), 462 - 469, 英語, 国内誌

    [査読有り]

    研究論文(学術雑誌)

  • 口腔癌cN(+)における根治的頸部郭清範囲の検討

    手島 直則, 窪田 雄一, 入谷 啓介, 蓼原 瞬, 古川 竜也, 四宮 弘隆, 大月 直樹, 武田 大介, 筧 康正, 長谷川 巧実

    (一社)日本頭頸部癌学会, 2020年07月, 頭頸部癌, 46 (2), 183 - 183, 日本語

  • 顎骨壊死を契機として切開排膿を要した咀嚼筋隙膿瘍の検討

    下間 祐輝, 武田 大介, 佐々木 亜紀, 小林 英里奈, 八橋 明子, 齋藤 泉, 楠元 順哉, 長谷川 巧実, 古土井 春吾, 明石 昌也

    (NPO)日本口腔科学会, 2020年07月, 日本口腔科学会雑誌, 69 (2), 121 - 121, 日本語

  • 当科で歯科介入を行った高用量骨吸収抑制薬使用患者におけるMRONJ発症とリスク因子についての検討

    廣田 純也, 長谷川 巧実, 武田 大介, 筧 康正, 楠元 順哉, 榊原 晶子, 木本 明, 明石 昌也

    (NPO)日本口腔科学会, 2020年07月, 日本口腔科学会雑誌, 69 (2), 153 - 153, 日本語

  • Takumi Hasegawa, Tomoya Iga, Daisuke Takeda, Rika Amano, Izumi Saito, Yasumasa Kakei, Junya Kusumoto, Akira Kimoto, Akiko Sakakibara, Masaya Akashi

    BACKGROUND: Prognostic biomarkers provide essential information about a patient's overall outcome. However, existing biomarkers are limited in terms of either sample collection, such as requiring tissue specimens, or the process, such as prolonged time for analysis. In view of the need for convenient and non-invasive prognostic biomarkers for oral cancer, we aimed to investigate the prognostic values of neutrophil-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, and platelet-to-lymphocyte ratio in patient survival. We also aimed to explore the associations of these ratios with the clinicopathologic characteristics of Japanese oral squamous cell carcinoma patients. METHODS: This study was a non-randomized retrospective cohort study in a tertiary referral center. We included 433 patients (246 men, 187 women) who underwent radical surgery for oral cancers between January 2001 and December 2013. We evaluated various risk factors for poor prognosis including neutrophil-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, and platelet-to-lymphocyte ratio with univariate and multivariate analyses. The disease-specific survival and overall survival rates of patients were compared among the factors and biomarkers. RESULTS: In multivariable Cox proportional hazards analysis, high neutrophil-to-lymphocyte ratio (hazard ratio 2.87, 95% confidence interval 1.59-5.19, P <  0.001), moderately or poorly differentiated histology (hazard ratio 2.37, 95% confidence interval 1.32-4.25, P <  0.001), and extranodal extension (hazard ratio 1.95, 95% confidence interval 1.13-3.35, P = 0.016) were independent predictors of disease-specific survival. High neutrophil-to-lymphocyte ratio (hazard ratio 2.30, 95% confidence interval 1.42-3.72, P <  0.001), moderately or poorly differentiated (hazard ratio 1.72, 95% confidence interval 1.07-2.76, P = 0.025), and extranodal extension (hazard ratio 1.79, 95% confidence interval 1.13-2.84, P = 0.013) were independent predictors of overall survival. CONCLUSIONS: Neutrophil-to-lymphocyte ratio might be a potential independent prognostic factor in Japanese oral squamous cell carcinoma patients.

    2020年06月17日, BMC cancer, 20 (1), 568 - 568, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Shin-Ichi Yamada, Takumi Hasegawa, Kohei Okuyama, Nobuhiro Yamakawa, Masaya Okura, Masao Hashidume, Souichi Yanamoto, Masaya Akashi, Tadaaki Kirita, Masahiro Umeda, Hiroshi Kurita

    OBJECTIVES: The present study investigated the clinical significance of the G8 screening tool in elderly oral squamous cell carcinoma (OSCC) patients using a multicenter analysis. MATERIALS AND METHODS: The medical records of 438 primary OSCC patients aged 75 years and older were retrospectively reviewed. To examine the clinical significance of the G8 screening tool in elderly OSCC patients, self-reliance (SR) rates and prognostic factors were statistically analyzed. RESULTS: The mean score of the G8 screening tool was 10.9 ± 2.93. The SR cut-off value of the G8 score was 9.5 in a receiver operating characteristic curve analysis. Five-year overall survival rates were 40.1% in patients with a G8 score < 9.5 and 58.4% in those with a G8 score ≥ 9.5 (p < 0.01). Five-year cancer-specific rates were 34.3% in patients with a G8 score < 9.5 and 55.7% in those with a G8 score ≥ 9.5 (p < 0.01). Five-year SR rates were 40.7% in patients with a G8 score < 9.5 and 55.3% in those with a G8 score ≥ 9.5 (p < 0.05). A multivariate analysis identified an advanced age (≥ 80 vs < 80; HR, 1.437; 95%CI, 1.181-1.843; p < 0.01), poorer ECOG-PS (2-4 vs 0-1; HR, 1.560; 95%CI, 1.14-2.106; p < 0.01), and standard treatment (non-standard therapy vs standard therapy; HR, 0.598; 95%CI, 0.405-0.910; p < 0.05) as significant independent prognostic factors for SR. A lower G8 score was associated with poorer SR (≥ 9.5 vs < 9.5; HR, 0.765; 95%CI, 0.575-1.034; p = 0.081). CONCLUSION: The clinical significance of the G8 score for elderly OSCC patients was demonstrated and its combination with ECOG-PS may be useful for assessing their prognoses.

    2020年06月, Clinical oral investigations, 24 (6), 1953 - 1961, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Takumi Hasegawa, Daisuke Takeda, Motofumi Tanaka, Rika Amano, Izumi Saito, Yasumasa Kakei, Akira Kimoto, Takumi Fukumoto, Masaya Akashi

    PURPOSE: This study retrospectively investigated relationships among risk factors and post-hepatectomy surgical site infection (SSI) and other complications in patients who underwent hepatectomy for hepatocellular carcinoma (HCC). METHODS: We included 334 patients who underwent hepatectomies for liver cancers between January 2011 and December 2015 in this study. We evaluated risk factors for SSI and other post-hepatectomy complication, including demographic factors, preoperative factors, and preoperative intervention including oral management, perioperative factors, and length of hospital stay, with univariate and multivariate analyses. The oral management intervention included self-care instructions, extraction of infected teeth, removal of dental plaques and calculus (scaling), professional mechanical teeth cleaning, removal of tongue coating, and cleaning of dentures. SSI was defined in accordance with the guideline issued by the Centers for Disease Control and Prevention; it included purulent discharge from any incision or organ space within 30 days postoperatively, with or without microbiological evidence. Complications of grade II or greater, according to the Clavien-Dindo classification, were regarded as postoperative complications. RESULTS: We found bacterial infection of ascites (Odds ratio (OR) = 13.72), lack of preoperative oral management intervention (OR = 10.17), and severe liver fibrosis (OR = 2.76) to be associated with SSI and severe liver fibrosis (OR = 2.28), hypoalbuminemia (OR = 2.02), blood transfusion (OR = 1.86), and longer operation time (OR = 1.80) to be associated with postoperative complications. CONCLUSIONS: Preoperative oral management may reduce the risk of SSI in patients with HCC who undergo hepatectomy.

    2020年05月18日, Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 29 (2), 653 - 659, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Factors associated with severe oral mucositis and candidiasis in patients undergoing radiotherapy for oral and oropharyngeal carcinomas: a retrospective multicenter study of 326 patients.

    Nishii M, Soutome S, Kawakita A, Yutori H, Iwata E, Akashi M, Hasegawa T, Kojima Y, Funahara M, Umeda M, Komori T.

    2020年05月, Support Care Cancer., 283 (3), 1069 - 1075

    [査読有り]

  • Yasumasa Kakei, Hirokazu Komatsu, Tsutomu Minamikawa, Takumi Hasegawa, Masanori Teshima, Hirotaka Shinomiya, Naoki Otsuki, Ken-Ichi Nibu, Masaya Akashi

    BACKGROUND: No clear consensus has been reached on the indication of supraomohyoid neck dissection (SOHND) for clinically positive lymph-node metastasis. PATIENTS: Consecutive 100 patients with previously untreated oral cancer treated at Kobe University Hospital were included in this study. All patients were clinically staged as anyTN1M0 and underwent radical dissection of the primary site and level I-V neck dissection as the initial treatment. RESULTS: None of the 100 patients had pathological lymph-node metastasis (pLN) to level V. pLN to level IV was observed in two patients with tongue cancer in whom clinical lymph-node metastasis was preoperatively observed at level II. CONCLUSIONS: Level V may be excluded in the neck dissection for patients with N1 oral cancers. Level IV dissection should be considered in the patient with tongue cancer and clinical lymph-node metastasis at level II.

    2020年03月05日, International journal of clinical oncology, 25 (6), 1067 - 1071, 英語, 国内誌

    [査読有り]

    研究論文(学術雑誌)

  • Shin-Ichi Yamada, Sakiko Soutome, Takumi Hasegawa, Itaru Tojyo, Hirokazu Nakahara, Mao Kawakami, Marina Hirose, Shigeyuki Fujita, Takahide Komori, Tadaaki Kirita, Yasuyuki Shibuya, Masahiro Umeda, Hiroshi Kurita

    Patients develop a number of oral complications during cancer treatments. Oral bacteria are associated with the onset of dental focal infections and the progression of oral mucositis. Dental focal infections are frequently associated with the systemic onset of bacteremia, sepsis, and pneumonia. The degeneration of oral function with these complications may become an obstacle to cancer treatments. Although comprehensive oral management, including oral care, the removal of dental focal infections, and improvements in oral function with dentures, is conducted for cancer patients in Japan, few studies have assessed its efficacy.The aim of the present study was to investigate the incidence of dental/oral complications in cancer patients with perioperative oral managements (POMs) based on a large number of case series with a multicenter retrospective analysis.The medical records of cancer patients with POMs were retrospectively reviewed and the incidence of oral complications and efficacy of oral management were investigated.A total of 2744 cancer patients with POMs (1684 males and 1080 females, mean age 65.9 ± 13.0 years) were included and investigated in the present study. Among these patients, 2097 (76.4%) started POM before the initiation of cancer treatments, with 2130 (77.6%) receiving oral care only and 391 (14.2%) being subjected to invasive treatments, such as tooth extraction. The incidence of dental focal infections during the period of cancer treatments was 8.2%. The most frequent infection was acute periodontitis, including alveolar abscesses (112 patients, 4.1%). The incidence of grade 2 and 3 oral mucositis was 2.8%. Prolonged fever was observed in 113 patients (4.1%), with 7 having dental focal infections (6.2%). These incidence rates were lower than those reported previously.Based on analyses of a large number of patients, the present results support the efficacy of oral management in cancer patients. However, further studies are needed to establish adequate oral management guidelines for cancer patients.

    2020年03月, Medicine, 99 (10), e19129, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Susumu Miura, Tetsu Nakamura, Takumi Hasegawa, Yukiko Miura, Gosuke Takiguchi, Naoki Urakawa, Hiroshi Hasegawa, Masashi Yamamoto, Shingo Kanaji, Yoshiko Matsuda, Kimihiro Yamashita, Takeru Matsuda, Taro Oshikiri, Satoshi Suzuki, Masaya Akashi, Yoshihiro Kakeji

    BACKGROUND: Oral health is associated with various diseases, including cancer. Tooth loss is a simple and objective index of oral health. OBJECTIVE: The purpose of this study was to investigate the association between preoperative tooth loss and esophageal cancer prognosis after esophagectomy. METHODS: This study included 191 patients who underwent esophagectomy for esophageal cancer after perioperative dental evaluation and oral care at Kobe University Hospital from April 2011 to March 2016. Patients were divided into two groups: Group A (tooth loss < 7) and Group B (tooth loss ≥ 7). Three-year overall survival (OS) and multivariate analysis were performed, along with subgroup analysis for elderly patients (age ≥ 65 years). RESULTS: The 3-year OS rate was 68.1% in Group A (104 patients) and 49.2% in Group B (87 patients). Group A had significantly higher OS than Group B (p = 0.002), and there were no significant differences in sex and clinical T or N stage between the two groups. However, the mean age of Group A was younger than that of Group B (64.2 vs. 68.5 years; p = 0.0002). Among elderly patients, the 3-year OS rate was 68.2% in Group A (55 patients) and 45.1% in Group B (65 patients) [p = 0.003]. Multivariate analysis that included age demonstrated that tooth loss is an independent prognostic factor (hazard ratio 1.87, 95% confidence interval 1.22-2.87), in addition to clinical T stage and preoperative serum albumin. CONCLUSION: Tooth loss is an independent prognostic factor for esophageal cancer after esophagectomy.

    2020年03月, Annals of surgical oncology, 27 (3), 683 - 690, 英語, 国際誌

    [査読有り]

  • Sakiko Soutome, Takumi Hasegawa, Taihei Yamguchi, Kumiko Aoki, Naritomo Kanamura, Takao Mukai, Junichi Yamazoe, Masaya Nishikawa, Emiko Isomura, Kazuto Hoshi, Masahiro Umeda

    PURPOSE: Postoperative pneumonia is one of the major complications after esophageal cancer surgery. The risk factors associated with postoperative pneumonia are poor general health, smoking, decreased pulmonary function, diabetes mellitus, surgical stress, old age, postoperative aspiration, and oral hygiene. In this study, we examined the effect of perioperative oral care on reducing postoperative pneumonia since the evidence to-date is not clear. METHODS: A multicenter, retrospective investigation of the relationship between perioperative oral care and incidence of postoperative pneumonia in patients undergoing esophageal cancer surgery was conducted. A total of 775 patients who underwent thoracoscopic esophageal resection at 25 hospitals between 2016 and 2017 were enrolled in the study. Various factors were examined for correlation with development of postoperative pneumonia. RESULTS: Multivariate analysis showed that old age, smoking habit, lower hemoglobin, higher creatinine, postoperative dysphagia, and lack of oral care intervention were independent risk factors for pneumonia. Oral care was more effective in preventing pneumonia in hospitals in which the incidence of postoperative pneumonia was lower than 20%, while it was not effective in hospitals in which the incidence was higher than 20%. CONCLUSION: Results of the study suggest that it is recommended to carry out perioperative oral care in esophageal cancer surgery.

    2020年01月02日, Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 28 (9), 4155 - 4162, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Saki Hayashida, Souichi Yanamoto, Shigeyuki Fujita, Takumi Hasegawa, Takahide Komori, Yuka Kojima, Hironori Miyamoto, Yasuyuki Shibuya, Nobuhiro Ueda, Tadaaki Kirita, Hirokazu Nakahara, Mitsuyo Shinohara, Eiji Kondo, Hiroshi Kurita, Masahiro Umeda

    Treatment strategies of medication-related osteonecrosis of the jaw (MRONJ) are controversial. Recently, surgical treatment has been reported as superior to nonsurgical treatment, but the contribution discontinued antiresorptive agent use during MRONJ treatment remains unclear. This study aimed to evaluate the efficacy of drug holidays and treatment strategies in MRONJ cases. Four-hundred and twenty-seven patients with MRONJ treated at nine hospitals from 2009 to 2017 were included in this multicenter retrospective study. Multivariate Cox regression analysis showed that the primary disease (osteoporosis or malignant tumor), diabetes, serum albumin, and treatment method (surgical or nonsurgical) were significantly correlated with the cure rate. The cumulative 1-year cure rates in the surgical and nonsurgical treatment groups were 64.7% and 18.2%, respectively. However, discontinuing antiresorptive agents did not influence the treatment outcome in the cohort overall, or in 230 patients after performing propensity score matching among the discontinuation and continuation groups. When stratifying by treatment method, antiresorptive agent discontinuation significantly increased the cure rate in patients with osteoporosis who underwent nonsurgical treatment. In patients with malignant tumors undergoing nonsurgical therapy, discontinuing the antiresorptive agent was associated with a better treatment outcome, but not with statistical significance. In contrast, drug holidays showed no effect on improving outcomes in patients with both osteoporosis and malignant tumors who underwent surgical therapy. Thus, regardless of the primary disease, discontinuing antiresorptive agents during treatment for MRONJ may not be necessary and may be helpful in some cases. Future prospective trials should examine this question further.

    2020年01月, Journal of bone and mineral metabolism, 38 (1), 126 - 134, 英語, 国内誌

    [査読有り]

    研究論文(学術雑誌)

  • Masahiko Kashin, Yasumasa Kakei, Shun Teraoka, Takumi Hasegawa, Akinobu Yamaguchi, Takao Fukuoka, Ryohei Sasaki, Masaya Akashi

    Cetuximab, an epidermal growth factor receptor inhibitor (EI), is currently the only targeted molecular therapy used in combination with radiotherapy for head and neck squamous cell carcinoma (HNSCC). Gold nanoparticles (AuNPs) are expected to enhance radiotherapy effects in cancers. To investigate whether AuNPs combined with AG1478, an EI, enhanced irradiation effects on HNSCC cells, we first examined AG1478 adsorption on AuNP surfaces, using surface-enhanced Raman scattering, which indicated an adsorption equilibrium of AG1478 to AuNPs. We then used transmission electron microscopy to find internalization rates of AuNP alone and AuNP+AG1478; we found that intracellular uptake of AuNP alone and AuNP+AG1478 did not significantly differ. We compared cell numbers, proliferation, apoptosis, and migration between control cells and those treated with or without 60 nm AuNP (1.0 nM), AG1478 (0.5 μM), and irradiation (4 Gy). We found that AuNP+AG1478 inhibited proliferation more than AG1478 alone; the combination of irradiation+AuNP+AG1478 significantly reduced total cell numbers compared with the combination of irradiation+AuNP; AuNP+AG1478 increased apoptotic reaction to irradiation; the combinations of AuNP+AG1478 and irradiation+AuNP induced more apoptosis than AG1478+irradiation. Whereas AuNP+AG1478 enhanced cytotoxicity in human HNSCC cells by inhibiting proliferation, irradiation+AuNP enhanced cytotoxicity by inducing apoptosis.

    2020年, BioMed research international, 2020, 1281645 - 1281645, 英語, 国際誌

    研究論文(学術雑誌)

  • 有本 智美, 長谷川 巧実, 松本 耕祐, 重岡 学, 南川 勉, 古森 孝英

    Papillary squamous cell carcinoma (PSCC) is a rare variant of squamous cell carcinoma with only a few documented cases in the oral cavity. We report the case of a 70-year-old man who presented with papillary squamous cell carcinoma of the mandibular gingiva.

    The patient was referred to our department because of a papillary tumor in the right mandibular gingiva. A physical examination revealed an exophytic papillary tumor in the right mandibular gingiva. Biopsy samples for histopathological diagnosis were taken two times. However, the biopsies did not reveal squamous cell carcinoma. Moreover, the pathological diagnosis obtained from intraoperative frozen-section analysis was cancer negative. Therefore, the operation consisted of resection of the tumor including a margin of 5-7 mm. Microscopically, the tumor showed exophytic papillary proliferation with fibrovascular cores and consisted of atypical squamous epithelial cells. The pathological diagnosis was PSCC. Three months later, local recurrence was observed and was resected again. The patient was healthy and remained free from tumors 18 months after the second operation. We report a rare case of PSCC. With small biopsy specimens, the diagnosis of PSCC was challenging.

    社団法人 日本口腔外科学会, 2020年, 日本口腔外科学会雑誌, 66 (5), 219 - 223, 日本語

  • Prevention of postoperative pneumonia by perioperative oral care

    Sakiko Soutome, Takumi Hasegawa, Taihei Yamaguchi, Kumiko Aoki

    2019年12月

    [査読有り]

  • Satomi Arimoto, Takumi Hasegawa, Daisuke Takeda, Chizu Tateishi, Masaya Akashi, Shungo Furudoi, Takahide Komori

    OBJECTIVE: The present study investigated the effect of low-intensity pulsed ultrasound (LIPUS) on long-term osseous healing of the cleavage space between bone fragments after intraoral vertical ramus osteotomy (IVRO). STUDY DESIGN: Patients undergoing IVRO were randomly assigned to the LIPUS group (n = 12) or the control group (n = 9) after surgery. LIPUS treatments were applied daily to the cleavage space between bone fragments for 3 weeks. We observed 3-dimensional quantitative color mapping of the whole mandible created by computed tomography (CT) data at 1 month, 6 months, and 1 year postoperatively. On the basis of CT values, the color grades were classified as D1 to D5 by using the Misch criteria. We then calculated mean CT values and rated each color grade in different selection ranges. RESULTS: The mean CT values of the LIPUS group were significantly higher than those of the control group at 1 month, 6 months and 1 year postoperatively (P < .01). The color grades of the cleavage between bone fragments increased from D5 to D1 over time. CONCLUSIONS: Our results indicated that LIPUS promoted osseous healing after IVRO, thus improving bone density and offering clinical benefits.

    2019年12月, Oral surgery, oral medicine, oral pathology and oral radiology, 128 (6), 581 - 589, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • 抗凝固薬内服患者における下顎智歯抜去後の後出血発症に関する多施設共同後ろ向き観察研究

    高田 亮, 山田 慎一, 長谷川 巧実, 五月女 さき子, 吉村 仁志, 宮腰 昌明, 上田 順宏, 岡本 健二朗, 菱田 純代, 横関 麻里, 中原 寛和, 藤田 茂之, 古森 孝英, 佐野 和生, 北川 善政, 渋谷 恭之, 桐田 忠昭, 梅田 正博, 栗田 浩

    (一社)日本有病者歯科医療学会, 2019年12月, 有病者歯科医療, 28 (6), 471 - 471, 日本語

  • Postoperative adjuvant therapy for patients with locoregionally advanced oral squamous cell carcinoma who are at high risk of recurrence.

    Yanamoto S, Denda Y, Ota Y, Hasegawa T, Akashi M, Okura M, Yamada S, Kurita H, Yamakawa N, Kirita T, Ueda M, Umeda M, the Japan Oral, Oncology, Group

    2019年11月27日, International Journal of Oral & Maxillofacial Surgery, in press

    [査読有り]

  • [総説]口腔・中咽頭がん患者の放射線性顎骨壊死発症リスク因子について:多施設共同後ろ向き研究の結果より

    兒島由桂, 河岡有美, 川下由美子, 山田慎一, 栗田 浩, 長谷川巧実, 古森孝英, 明石昌也, 上田順宏, 桐田忠昭, 高島裕之, 渋谷恭之, 梅田正博

    2019年09月15日, 日本口腔腫瘍学会誌, 31 (3), 117-120

  • Yumi Muraki, Masaya Akashi, Yasuo Ejima, Takumi Hasegawa, Daisuke Miyawaki, Hirotaka Shinomiya, Mika Nishii, Naoki Otsuki, Ryohei Sasaki, Ken-Ichi Nibu, Takahide Komori

    BACKGROUND: The purpose of this study was to investigate the effectiveness of dental intervention before and after radiation therapy (RT) for head and neck malignancy on prevention of osteoradionecrosis (ORN) of the jaws. METHODS: This is a single-arm prospective study according to intervention protocol of prophylactic dental extraction before RT and routine follow-up after RT. The primary endpoint was the occurrence of jawbone exposure during the first 2 years after RT. RESULTS: Sixty-seven patients were assessed. Before RT, 144 teeth among 39 patients (58%) were prophylactically extracted. The occurrence of transient jawbone exposure during the first 2 years after RT was 7%. Because those jawbone exposures healed with intervention after RT, no jawbone exposure was found at 2 years after RT. CONCLUSIONS: Dental intervention both before and after RT seemed to be important to prevent ORN development. Further studies in larger cohorts are necessary.

    2019年09月, Oral and maxillofacial surgery, 23 (3), 297 - 305, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Sakakibara A, Kusumoto J, Sakakibara S, Hasegawa T, Akashi M, Minamikawa T, Furudoi S, Hashikawa K, Komori T.

    BACKGROUND AND OBJECTIVE: Forearm free flaps are used after hemiglossectomy. However, no investigation has been performed on whether oral functions are better preserved when sizes of the resection and reconstruction flap are exact matches, or whether the size of the resection should be changed. We aimed to retrospectively examine whether size differences between the resection and reconstruction flap affect speech and swallowing functions postoperatively, and to determine whether there are more favorable flap size ratios. METHODS: This is a retrospective cohort study of patients undergoing hemiglossectomy using a forearm free flap between 2006 and 2016 at Kobe University Hospital, Japan. The effect of size difference between the resection and reconstruction flap on maintained oral function was assessed. Speech and swallowing functions were assessed, and their correlation with the ratio of the flap size to that of the resected area was determined. With these data, distribution maps of the relationship between the functional level and reconstructed dimension ratio were prepared. The more suitable reconstructed dimension ratio was examined and evaluated. The Fisher exact test, Kruskal-Wallis test, and Scheffe test were used in statistical analyses. RESULTS: Eighty-eight patients underwent hemiglossectomy using a forearm free flap during a 10-year period. Of these cases, 66 patients were included in this study, while 22 were excluded. The ratio of the area of the reconstruction flap to that of the resection site was 0.59-2.79 (median: 1.61). Sixty patients had flaps greater than the resection area, whereas 6 had smaller flaps. Significant differences were found in speech intelligibility and swallowing function when the reconstructed dimension ratio was categorized as follows: ≤1.3, 1.3-1.8, and ≥1.8. CONCLUSION: Our findings suggest that postoperative deterioration of oral functions after hemiglossectomy could be reduced if reconstruction is performed using a forearm free flap with a surface area 1.3 to 1.8 times greater than that of the resection area.

    2019年07月, J Plast Reconstr Aesthet Surg, 72 (7), 1135 - 1141, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Hasegawa T, Yanamoto S, Otsuru M, Kakei Y, Okura M, Yamakawa N, Yamada SI, Ota Y, Umeda M, Kirita T, Kurita H, Ueda M, Komori T, Japan Oral Oncology Group (JOOG).

    BACKGROUND: The purpose of this study was to retrospectively describe the characteristics and outcomes of patients with oral squamous cell carcinoma and level IV/V metastasis and to compare patients who underwent no postoperative therapy with those who underwent postoperative radiotherapy (RT) and concomitant chemoradiotherapy (CCRT). METHODS: We evaluated 669 patients. Clinicopathological data, postoperative therapy, and clinical course were investigated. RESULTS: Sixty-one patients (9.1%) developed level IV/V metastasis. The 3-year cumulative overall survival rates of patients with and without level IV/V metastasis were 47.3% and 64.3%, respectively. Tongue tumors, pN2 or N3 classification, and moderate or poor differentiation were significantly associated with the development of level IV/V metastasis. The surgery+RT/CCRT group was associated with better 3-year cumulative disease-specific survival and overall survival rates than the surgery only group. CONCLUSION: Adjuvant therapy (RT alone or CCRT) after surgery is recommended for patients with level IV/V metastasis.

    2019年07月, Head Neck., 41 (7), 2256 - 2263, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Daisuke Takeda, Takumi Hasegawa, Izumi Saito, Satomi Arimoto, Masaya Akashi, Takahide Komori

    PURPOSE: Evaluation of the inner aspect of the maxillary sinus is important for the success of a sinus lift procedure. The most common surgical complication is perforation of the Schneiderian membrane, which is thought to occur because of the presence of maxillary sinus septa. Therefore, we retrospectively investigated the incidence and morphology of maxillary sinus septa using multiplanar reformatted computed tomographic (CT) images from dentate Japanese patients. METHODS: A total of 276 patients and 552 maxillary sinus segments were evaluated. The maxillary sinus septa were divided into four locations: forefront, anterior, middle, and posterior. The heights of the septa were measured at three sites from the deepest point of the sinus floor: lateral, mid-point, and medial. RESULTS: Sinus septa were identified in 191 of 552 (34.6%) maxillary sinus segments obtained from 111 of 276 (40.2%) patients. One unilateral septum was most commonly detected, and the sinus septa were most often located in the middle of the maxillary sinus. The average height of the identified septa was 8.69 ± 4.68 mm (mean ± standard deviation). CONCLUSION: Multiplanar reformatted CT images can identify maxillary sinus septa in any plane. The height of maxillary sinus septa in the dentate maxillae was higher than detected in previous studies. Appropriate treatment planning using CT images should be considered to prevent surgical complications.

    2019年06月, Oral and maxillofacial surgery, 23 (2), 233 - 237, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Iwata E, Hasegawa T, Yamada SI, Kawashita Y, Yoshimatsu M, Mizutani T, Nakahara H, Mori K, Shibuya Y, Kurita H, Komori T.

    BACKGROUND: Postoperative pneumonia can be a fatal complication that may occur after lung resection in cancer patients. Some reports have shown that the incidence of postoperative pneumonia is decreased after esophageal surgery by perioperative oral care; however, there exist no data to suggest that a lack of perioperative oral care can be a risk factor for postoperative pneumonia after lung resection. To investigate the association between the preventive effect of oral care and postoperative pneumonia, we conducted a multicenter, retrospective study of lung cancer patients who underwent lung resection. METHODS: Between January 2014 and December 2016, a total of 721 patients underwent lung resections at 1 of the 6 hospitals included in our study. Among 721 patients, 280 (38.8%) received perioperative oral care, and the remaining 441 (61.2%) did not receive any such care. Propensity score matching was performed to minimize selection biases associated with the comparison of retrospective data between the oral care and control groups. RESULTS: Of the 721 patients, 54 (7.5%) experienced postoperative pneumonia involving 13 of the 280 patients (4.6%) in the oral care group and 41 of the 441 patients (9.3%) in the control group (P = .02). On propensity score analysis, a significant difference was also found between oral care intervention and incidence of postoperative pneumonia (P = .002). CONCLUSION: Our results suggest that perioperative oral care is an effective method to decrease the occurrence of postoperative pneumonia in patients who have undergone lung resection.

    2019年05月, Surgery, 165 (5), 1003 - 1007, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Clinical Evaluation of CO2 Laser Vaporization Therapy for Oral Lichen Planus: A Single-Arm Intervention Study.

    Matsumoto K, Matsuo K, Yatagai N, Enomoto Y, Shiegoka M, Hasegawa T, Suzuki H, Komori T

    2019年05月, Photobiomodul Photomed Laser Surg, 37 (3), 175 - 81, 英語

    [査読有り]

    研究論文(学術雑誌)

  • 多施設共同研究 高用量骨吸収抑制薬投与患者の抜歯と顎骨壊死発症 本学会共同研究委員会による多施設共同前向き研究の提案 抜歯例について

    長谷川 巧実, 船原 まどか, 梅田 正博, 夏目 長門, 日本口腔ケア学会共同研究委員会ワーキング3

    (一社)日本口腔ケア学会, 2019年04月, 日本口腔ケア学会雑誌, 13 (3), 120 - 120, 日本語

  • 多施設共同研究 高用量骨吸収抑制薬投与患者の顎骨壊死発症予防法 本学会共同研究委員会による多施設共同前向き研究の提案 非抜歯例について

    兒島 由佳, 長谷川 巧実, 船原 まどか, 梅田 正博, 夏目 長門, 日本口腔ケア学会共同研究委員会ワーキング3

    (一社)日本口腔ケア学会, 2019年04月, 日本口腔ケア学会雑誌, 13 (3), 122 - 122, 日本語

  • Yumi Muraki, Takumi Hasegawa, Daisuke Takeda, Takeshi Ueha, Eiji Iwata, Izumi Saito, Rika Amano, Akiko Sakakibara, Masaya Akashi, Takahide Komori

    BACKGROUND/AIM: We recently investigated the contribution of the iPS-related genes SOX2, OCT4, and Nanog to de-differentiation by assaying for their mRNA levels. Given that mRNA expression does not always correlate with the protein levels, the aim of this study was to retrospectively determine the expression of these four iPS-related factors in human OSCC specimens by immunohistochemistry and examine their association with patient prognosis. MATERIALS AND METHODS: iPS cell-related gene expression in 89 OSCC patients by tissue microarray, and its correlation with clinicopathological factors, differentiation, metastasis, and poor prognoses were investigated. RESULTS: No evidence of statistically significant relationships was found between the expression of iPS cell-related genes and clinicopathological parameters. However, our data indicated that KLF4 expression was associated with survival, and poor tumor differentiation. In addition, high expression of KLF4 was an independent poor prognostic factor (p=0.004) for OSCC patients. CONCLUSION: In preoperative biopsies, higher KLF4 and poor differentiation may be clinically effective predictors for the prognosis of oral cancer.

    2019年03月, Anticancer research, 39 (3), 1205 - 1216, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Yamakawa N, Kirita T, Umeda M, Yanamoto S, Ota Y, Otsuru M, Okura M, Kurita H, Yamada SI, Hasegawa T, Aikawa T, Komori T, Ueda M, Japan Oral, Oncology, Group

    Background and Objectives Some patients with early-stage oral cancer have a poor prognosis owing to the delayed neck metastasis (DNM). Tumor budding is reportedly a promising prognostic marker in many cancers. Moreover, the tissue surrounding a tumor is also considered to play a prognostic role. In this study, we evaluated whether tumor budding and adjacent tissue at the invasive front can be potential novel predictors of DNM in early tongue cancer. Methods In total, 337 patients with early-stage tongue squamous cell carcinoma were retrospectively reviewed. The patient characteristics and histopathological factors were evaluated for association with DNM. DNM rates were calculated; items which were significant in the univariate analysis were used as explanatory variables, and independent factors for DNM were identified by the multivariate analysis. Results The univariate analysis identified T classification, depth of invasion, tumor budding, vascular invasion, and adjacent tissue at the invasive front as significant predictors of DNM; the multivariate analysis using these factors revealed all the above variables except vascular invasion, which are independent predictors of DNM. Conclusion In addition to conventional predictors, high grade tumor budding and adjacent tissue at the invasive front can serve as useful predictors of DNM in early tongue cancer.

    WILEY, 2019年03月, J Surg Oncol, 119 (3), 370 - 378, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Mitsunobu Otsuru, Yoshihide Ota, Souichi Yanamoto, Masaya Okura, Masahiro Umeda, Tadaaki Kirita, Hiroshi Kurita, Michihiro Ueda, Takahide Komori, Nobuhiro Yamakawa, Takahiro Kamata, Takumi Hasegawa, Takahiko Shibahara, Youichi Ohiro, Yoshihiro Yamashita, Kazuma Noguchi, Tadahide Noguchi, Kazunari Karakida, Hiroyuki Naito, Tomonao Aikawa, Tetsuro Yamashita, Daijiro Kabata, Ayumi Shintani

    BACKGROUND: This multicenter retrospective study aimed to determine whether elective neck dissection (END) can be performed for T1-2N0M0 tongue cancer. METHODS: Patients with T1-2N0M0 tongue squamous cell carcinoma who received treatment between January 2000 and December 2012 were enrolled at 14 multicenter study sites. The 5-year overall survival (OS) and 5-year disease-specific survival (DSS) were compared between the propensity score-matched END and observation (OBS) groups. RESULTS: The results showed that the OS rates among the 1234 enrolled patients were 85.5% in the END group and 90.2% in the OBS group (P = 0.182). The DSS rates were 87.0% in the END group and 94.3% in the OBS group (P = 0.003). Among the matched patients, the OS rates were 87.1% in the END group and 76.2% in the OBS group (P = 0.0051), and the respective DSS rates were 89.2% and 82.2% (P = 0.0335). CONCLUSION: This study showed that END is beneficial for T1-2N0M0 tongue cancer. However, END should be performed for patients with a tumor depth of 4-5 mm or more, which is the depth associated with a high rate of lymph node metastasis. The use of END should be carefully considered for both elderly and young patients.

    2019年02月, Annals of surgical oncology, 26 (2), 555 - 563, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Hasegawa T, Hayashida S, Kondo E, Takeda Y, Miyamoto H, Kawaoka Y, Ueda N, Iwata E, Nakahara H, Kobayashi M, Soutome S, Yamada SI, Tojyo I, Kojima Y, Umeda M, Fujita S, Kurita H, Shibuya Y, Kirita T, Komori T, Japanese Study, Group of Co-operative Dentistry with Medicine(JCDM

    Summary: Root amputation, immunosuppressive therapy, mandibular tooth extraction, pre-existing inflammation, and longer duration of treatment with bone-modifying agents were significantly associated with an increased risk of medication-related osteonecrosis of the jaw. Hopeless teeth should be extracted without drug holiday before the development of inflammation in cancer patients receiving high-dose bone-modifying agents. Introduction: No studies have comprehensively analyzed the influence of pre-existing inflammation, surgical procedure–related factors such as primary wound closure, demographic factors, and drug holiday on the incidence of medication-related osteonecrosis of the jaw (MRONJ). The purpose of this study was to retrospectively investigate the relationships between these various factors and the development of MRONJ after tooth extraction in cancer patients receiving high-dose bone-modifying agents (BMAs) such as bisphosphonates or denosumab. Methods: Risk factors for MRONJ after tooth extraction were evaluated with univariate and multivariate analyses. The following parameters were investigated in all patients: demographics, type and duration of BMA use, whether BMA use was discontinued before tooth extraction (drug holiday), the duration of such discontinuation, the presence of pre-existing inflammation, and whether additional surgical procedures (e.g., incision, removal of bone edges, root amputation) were performed. Results: We found that root amputation (OR = 22.62), immunosuppressive therapy (OR = 16.61), extraction of mandibular teeth (OR = 12.14), extraction of teeth with pre-existing inflammation, and longer duration (≥ 8 months) of high-dose BMA (OR = 7.85) were all significantly associated with MRONJ. Conclusions: Tooth extraction should not necessarily be postponed in cancer patients receiving high-dose BMA. The effectiveness of a short-term drug holiday was not confirmed, as drug holidays had no significant impact on MRONJ incidence. Tooth extraction may be acceptable during high-dose BMA therapy until 8 months after initiation.

    2019年01月, Osteoporos Int, 30 (1), 231 - 239, 英語

    [査読有り]

    研究論文(学術雑誌)

  • MRONJ治療時の休薬の意義はあるか?

    林田 咲, 坂本 英之, 長谷川 巧実, 古森 孝英, 兒島 由佳, 河岡 有美, 上田 順宏, 桐田 忠昭, 宮本 大模, 渋谷 恭之, 篠原 光代, 中原 寛和, 近藤 英司, 栗田 浩, 藤田 茂之, 梅田 正博

    (一社)日本有病者歯科医療学会, 2018年12月, 有病者歯科医療, 27 (6), 495 - 495, 日本語

  • Satomi Arimoto, Takumi Hasegawa, Daisuke Takeda, Izumi Saito, Rika Amano, Masaya Akashi, Takahide Komori

    BACKGROUND/AIM: Tumor lymphangiogenesis plays a key role in lymph node (LN) metastasis in oral squamous cell carcinoma (OSCC). The purpose of this study was to investigate podoplanin and lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1) and their relationship to nodal metastasis and other clinicopathological variables. PATIENTS AND METHODS: Podoplanin and LYVE-1 expression of the primary tumor and normal tissue were investigated by means of a quantitative real-time PCR assay and immunohistochemistry in samples from 33 cases of OSCC. RESULTS: The mRNA high expression levels of both genes had a statistically significantly higher rate of LN metastasis (p<0.01) and histological grade (p<0.01 for podoplanin, p<0.05 for LYVE-1). High expression of each gene, as shown by immunohistochemistry, had a statistically significant higher rate of LN metastasis (p<0.01 for podoplanin, p<0.05 for LYVE-1). CONCLUSION: Podoplanin and LYVE-1 were strongly associated with LN metastasis.

    2018年11月, Anticancer research, 38 (11), 6157 - 6162, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Teraoka S, Kakei Y, Akashi M, Iwata E, Hasegawa T, Miyawaki D, Sasaki R, Komori T

    Enhancing the antitumor effect of radiation, while reducing damage to organs, is a significant challenge in radiation therapy for head and neck malignancies. One promising radiosensitizer is gold. The present study aimed to determine whether gold nanoparticles (AuNPs) have the potential to enhance the effects of X-ray irradiation on head and neck cancer cells. The human head and neck carcinoma cell line HSC-3 was used. Total cell number and the levels of cell proliferation and apoptosis were compared between control cells and cells treated with 5-nm AuNPs alone at four concentrations (0.1, 0.4, 1.0 and 10.0 nM), X-ray irradiation alone at three doses (2, 4 and 8 Gy), or a combination of 4 Gy X-ray irradiation and 1.0 nM AuNPs. Analysis of variance and Tukey-Kramer testing were performed to compare the different groups. The total number of cells significantly decreased following 4 and 8 Gy X-ray irradiation, compared with in the control group (control vs. 4Gy, P=2.19×10-4; control vs. 8Gy, P=1.28×10-6). The combination of 4 Gy X-ray irradiation and 1.0 nM AuNPs significantly reduced the total number of cells compared with 4 Gy X-ray irradiation alone (P=2.95×10-4). Cell proliferation was not affected by AuNP treatment alone, 4 Gy X-ray irradiation alone or the combination of X-ray irradiation and AuNPs. The combination of 4 Gy irradiation and 1.0 nM AuNPs significantly increased the number of apoptotic cells compared with 4 Gy irradiation alone (P=0.0261). In conclusion, AuNPs combined with X-ray irradiation enhanced the cytotoxic effect on human head and neck cancer cells in vitro, through the induction of apoptosis, but not inhibition of cell proliferation.

    2018年11月, Biomed Rep, 9 (5), 415 - 420, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Izumi Saito, Takumi Hasegawa, Takeshi Ueha, Daisuke Takeda, Eiji Iwata, Satomi Arimoto, Akiko Sakakibara, Masaya Akashi, Shunsuke Sakakibara, Yoshitada Sakai, Hiroto Terashi, Takahide Komori

    INTRODUCTION: Skin flap procedures are widely used to reconstruct skin and soft tissue defects. Skin flap necrosis is a serious postoperative complication. Many researchers have introduced pharmacological agents to improve flap ischemia in experimental studies. However, outcomes of these studies remain controversial. We previously demonstrated that transcutaneous CO2 application improves hypoxia in fracture repair. In this study, we hypothesized that improving hypoxia by transcutaneous CO2 application can improve the blood flow in skin flaps and increase angiogenesis. We investigated whether transcutaneous CO2 application can increase the survival of random-pattern skin flaps. MATERIALS AND METHODS: Six-week-old male Sprague-Dawley rats were divided into two equal groups: the control group (n = 6) and CO2 group (n = 6). A random-pattern skin flap was constructed in these rats. Topical CO2 was applied using a hydrogel every day for 5 days in the CO2 group. The flap survival area was measured on postoperative days 1, 3, and 5. The vessel density and expression of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), and hypoxia-inducible factor-1α (HIF-1α) were evaluated on postoperative day 5. RESULTS: A statistically significant difference was found in the percentage of the flap survival area between the two groups on postoperative days 3 and 5 (p < 0.05). Furthermore, the expression of VEGF and bFGF was significantly higher and that of HIF-1α was significantly lower in the CO2 than in the control group (p < 0.05). CONCLUSIONS: Transcutaneous CO2 application can improve the blood flow in skin flaps and increase angiogenesis, thus increasing the survival of random-pattern skin flaps.

    2018年11月, Journal of plastic, reconstructive & aesthetic surgery : JPRAS, 71 (11), 1644 - 1651, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • 当科におけるインプラント埋入症例と喪失リスク因子に関する後ろ向き観察研究

    長谷川 巧実, 武田 大介, 齋藤 泉, 有本 智美, 筧 康正, 明石 昌也, 鈴木 泰明, 古森 孝英

    (公社)日本顎顔面インプラント学会, 2018年11月, Japanese Journal of Maxillo Facial Implants, 17 (3), 224 - 224, 日本語

  • 癌患者の口腔機能管理の基準に関する多施設共同後ろ向き観察研究

    山田 慎一, 五月女 さき子, 長谷川 巧実, 東條 格, 中原 寛和, 河上 真緒, 廣瀬 満理奈, 藤田 茂之, 古森 孝英, 桐田 忠昭, 渋谷 恭之, 梅田 正博, 栗田 浩

    (一社)日本癌治療学会, 2018年10月, 日本癌治療学会学術集会抄録集, 56回, P1 - 1, 英語

    [査読有り]

  • 希少がんである口腔癌を多方面から考える 早期舌癌における頸部後発転移に対する新規予測因子の検討

    山川 延宏, 桐田 忠昭, 梅田 正博, 柳本 惣市, 太田 嘉英, 大鶴 光信, 大倉 正也, 相川 友直, 栗田 浩, 山田 慎一, 古森 孝英, 長谷川 巧実, 上田 倫弘, 日本口腔がん臨床研究グループ

    (一社)日本癌治療学会, 2018年10月, 日本癌治療学会学術集会抄録集, 56回, SY12 - 3, 英語

  • Sakakibara A, Kusumoto J, Sakakibara S, Hasegawa T, Akashi M, Minamikawa T, Furudoi S, Hashikawa K, Komori T

    OBJECTIVE:  Musculocutaneous flap reconstruction surgery is one of the standard procedures following head and neck cancer resection. However, no previous studies have classified flaps in terms of muscle and fat or examined them after long-term follow-up. The purpose of this study was to estimate the fat and muscle volume changes in musculocutaneous flaps during long-term follow-up. METHODS:  We conducted a retrospective analysis of 35 patients after musculocutaneous flap reconstruction. The total, fat, and muscle volumes of the musculocutaneous flaps were measured using 3-dimensional images. Changes in flap volumes over time (1 month, 1 year [POY1], and 5 years [POY5] postoperatively) were assessed. Flap persistence was calculated using flap volumes at 1 month after reconstruction for reference. RESULTS:  Flap persistence at POY5 was 42.0% in total, 64.1% in fat, and 25.4% in muscle. Muscle persistence was significantly decreased (p < 0.0001). In a multiple regression analysis, decreased body mass index (BMI) of ≥ 5% influenced fat persistence less than muscle persistence at POY1; however, there was no significant difference at POY5. Postoperative radiation therapy was associated with a significant decrease in total flap persistence at POY1 (p = 0.046) and POY5 (p = 0.0097). Muscle persistence significantly decreased at POY5 (p = 0.0108). Age significantly influenced muscle volume at POY1 (p = 0.0072). CONCLUSION:  Reconstruction flaps are well-preserved with high fat-to-muscle ratios. Recommendations for weight maintenance are necessary for patients less than 2 years after surgery due to the influence of BMI on fat persistence. Radiation therapy is necessary for some patients based on their disease state. Intensity-modulated radiation therapy can be offered to reduce scattering irradiation to normal tissues.

    2018年09月, J Reconstr Microsurg, 35 (4), 235 - 243, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Kishimoto M, Akashi M, Kakei Y, Kusumoto J, Sakakibara A, Hasegawa T, Furudoi S, Sasaki R, Komori T

    BACKGROUND: A problematic complication after radiation therapy is lymphedema. Development of lymphedema is associated with an increase in lymphatic paracellular permeability. The current study investigated the effects of radiation on intercellular junctions and paracellular permeability in cultured human dermal lymphatic endothelial cells (HDLECs). METHODS AND RESULTS: Double immunofluorescence staining with vascular endothelial (VE)-cadherin and actin immediately after X-ray irradiation (5 or 20 Gy) was performed. Morphological changes induced by irradiation were assessed. Cell viability and paracellular permeability after irradiation were also evaluated. Broad junctions in which VE-cadherin was accumulated at cell-cell contacts and almost colocalized with actin were significantly decreased in a dose-dependent manner in confluent and sparse irradiated HDLECs. Irradiation shortened the width of VE-cadherin-positive areas at the cell-cell contacts. Actin filaments did not colocalize with VE-cadherin after 20 Gy irradiation. Although cell viability was not affected by irradiation, paracellular permeability significantly increased in a dose-dependent manner. CONCLUSIONS: A dose of 5 or 20 Gy irradiation in HDLECs does not affect cell viability, but changes VE-cadherin mediated intercellular junctions and actin structure, resulting in an increase of paracellular permeability. Further investigations on the regulatory proteins involved in radiation-induced changes, which were observed in the current study, may contribute to development of lymphedema therapy.

    2018年08月, Lymphat Res Biol, 16 (4), 390 - 396, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Eiji Iwata, Takumi Hasegawa, Takeshi Ueha, Daisuke Takeda, Izumi Saito, Teruya Kawamoto, Toshihiro Akisue, Yoshitada Sakai, Ryohei Sasaki, Ryosuke Kuroda, Takahide Komori

    Radiotherapy (RT) is one of the main treatment modalities for oral squamous cell carcinoma (OSCC), however, radioresistance is a major impediment to its clinical success and poses as a concern that needs to be addressed. Tumor hypoxia is known to be significantly associated with radioresistance in various malignancies, hence, resolving the hypoxic state of a tumor may improve the antitumor effect of RT on OSCC. We have previously revealed that transcutaneous CO2 induced mitochondrial apoptosis and suppressed tumor growth in OSCC by resolving hypoxia. Considering the previous study, we hypothesized that transcutaneous CO2 may enhance the antitumor effect of RT on OSCC by improving intratumoral hypoxia, thereby overcoming radioresistance. In the present study, the combination of transcutaneous CO2 and RT significantly inhibited tumor growth compared with other treatments. This combination therapy also led to decreased expression of HIF-1α in parallel with increased expression of the cleaved forms of caspase-3-8-9 and PARP, which play essential roles in mitochondrial apoptosis. Additionally, the combination therapy increased the expression of ROS modulator 1 and subsequent mitochondrial ROS production, compared to RT alone. These results indicated that transcutaneous CO2 could potentially improve the antitumor effect of RT by decreasing the intratumoral hypoxia and increasing the mitochondrial apoptosis. Our findings indicated that CO2 therapy may be a novel adjuvant therapy in combination with RT for OSCC.

    2018年07月, Oncology reports, 40 (1), 434 - 442, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Hasegawa T, Yanamoto S, Otsuru M, Kakei Y, Okura M, Yamakawa N, Yamada SI, Ota Y, Umeda M, Kirita T, Kurita H, Ueda M, Komori T, Japan Oral, Oncology, Group

    BACKGROUND: Oral squamous cell carcinoma (OSCC) containing single lymph node metastasis (pN1) with extra nodal extension (ENE) is a rare clinical situation. Therefore, it is unclear whether pN1 with ENE is at high risk of recurrence among the OSCC population, or whether postoperative radiotherapy (RT)/concomitant chemoradiotherapy (CCRT) is effective in these cases. OBJECTIVES: The purpose of this retrospective study was to investigate the prognosis and compare between no postoperative therapy and postoperative RT/CCRT in pN1 with ENE OSCC patients. METHODS: Clinicopathological data and treatment modalities were investigated. The evaluated endpoints were overall survival (OS) and type of recurrence. RESULTS: The 3-year cumulative OS rates for the pN1 only, multiple lymph node metastasis (MLM) only, ENE + MLM, and ENE + pN1 groups were 77.2%, 66.8%, 43.3%, and 66.6%, respectively. In the ENE + pN1 group, the most common cause of death in the surgery only group was from regional failure. The surgery + RT/CCRT group was associated with better disease-specific survival and OS rates than the surgery only groups (P < 0.05). CONCLUSIONS: The prognosis of ENE + pN1 was not as poor as that of ENE + MLM, although both these groups feature ENE. Adjuvant therapy (RT/CCRT) after surgery is recommend for cases of ENE + pN1.

    2018年06月, J Surg Oncol, 117 (8), 1736 - 1743, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Masaya Akashi, Takumi Hasegawa, Satoru Takahashi, Takahide Komori

    Temporomandibular joint (TMJ) osteoarthritis (OA) is a disease of the bone, cartilage, and supporting tissues of the joint. Patients with advanced TMJ-OA often have symptoms such as pain, swelling, and joint dysfunction, and they sometimes require surgical intervention when conservative treatment is not effective. The etiology of TMJ-OA remains elusive. The usefulness of 4-dimensional (4D) computed tomography (CT) in motion analysis of various joints has recently been reported. This article introduces a novel imaging technique of 4D CT that aims to identify kinematic features that may be associated with the etiology of TMJ-OA. In a 69-year-old female patient with severe TMJ-OA, 4D CT evaluation of condylar movement was performed. During the scan, she was instructed to masticate a cookie normally and her natural condylar movement during mastication was evaluated. The coronal 4D CT motion images showed that the synovial cavity was narrower on the affected side than on the unaffected side. Repeated friction between the articular surface of the condyle and the caudal surface of the articular eminence was observed during natural mastication. Although friction between the condyle and articular eminence has been considered a factor in the initiation and progression of TMJ-OA in previous experimental studies using animals, this is the first study to directly visualize the friction between the atrophic and flattened condylar surface and the articular eminence. Four-dimensional CT is a novel imaging technique with the potential to assess kinematic features that cannot be visualized with other imaging modalities in patients with TMJ disease.

    W.B. Saunders, 2018年02月01日, Journal of Oral and Maxillofacial Surgery, 76 (2), 304 - 313, 英語

    [査読有り]

    研究論文(学術雑誌)

  • HasegawaT, YamadaSI, UedaN, SoutomeS, FunaharaM, AkashiM, FurunoS, MiyamotoH, HayashidaS, AmanoR, MoriK, KojimaY, KuritaH, KiritaT, UmedaM, ShibuyaY, FujitaS, KomoriT

    Little research has been conducted into hypoesthesia, and no studies have elucidated the risk factors for refractory hypoesthesia and compared treatment modalities. The purpose of this multicentre retrospective cohort study was to investigate the relationships between various risk factors, treatment modalities, and refractory hypoesthesia. Risk factors for refractory hypoesthesia after oral surgery were evaluated using univariate and multivariate analysis. To minimize the selection bias associated with a retrospective data analysis, a propensity score analysis was performed between the medication and non-medication groups (65 sites in each group). Moderate or severe hypoesthesia (odds ratio 13.42) and no or late administration of ATP/vitamin B12 (odds ratio 2.28) were significantly associated with refractory hypoesthesia. In the propensity score analysis, the incidence rate of refractory hypoesthesia in the medication group was lower than that in the non-medication group (P < 0.001). This study demonstrated the multivariate relationships between various risk factors, treatment modalities, and refractory hypoesthesia. Moderate or severe hypoesthesia and no or late administration of ATP/vitamin B12 were significantly associated with refractory hypoesthesia. Therefore, clinicians should consider these risk factors and initiate early oral administration of ATP/vitamin B12 in cases of hypoesthesia.

    2018年01月, Int J Oral Maxillofac Surg, 47 (6), 794 - 801, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Yujiro Hiraoka, Masaya Akashi, Satoshi Wanifuchi, Junya Kusumoto, Manabu Shigeoka, Takumi Hasegawa, Kazunobu Hashikawa, Hiroto Terashi, Takahide Komori

    Objective: Pain is one of the most problematic symptoms in patients with osteoradionecrosis of the jaws. This study investigated the associations between pain severity and morphologic alterations of the mandibular canal and inferior alveolar nerve, in respective computerized tomography images and resected specimens of mandibular osteoradionecrosis. Study Design: We assessed 14 lesions in 13 patients who underwent segmental mandibulectomy for surgical debridement and simultaneous reconstruction with free fibula flap (1 patient exhibited bilateral lesions). The extent of the mandibular canal bone defect on preoperative coronal computerized tomography images and the number of inferior alveolar nerve fascicles in resected specimens were evaluated. Comparisons were made between the slight pain and extreme pain groups. In most of the patients in the extreme pain group, either mandibular canal bone defects were absent or entire circumferential defects were present inferior alveolar nerve fascicles were either distinguishable or completely absent in the resected specimens. Results: Although there was no statistically significant association between extreme pain and computerized tomography or histopathologic findings, the histopathologically indistinguishable inferior alveolar nerve fascicles was significantly associated with slight pain. Conclusions: The degree of degeneration of mandibular canal and inferior alveolar nerve may be associated with pain severity in patients with mandibular osteoradionecrosis.

    Mosby Inc., 2018年, Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 126 (3), 264 - 71, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Takumi Hasegawa, Souichi Yanamoto, Akira Tachibana, Yuka Kojima, Yoshito Koyama, Michinori Maeda, Takahide Komori, Japanese Study Group of Cooperative Dentistry with Medicine (JCDM)

    The purpose of this study was to retrospectively investigate the multivariate relationships between specific risk factors and postoperative hemorrhage after tooth extraction in patients who were prescribed oral antithrombotic therapy. Risk factors for postoperative hemorrhage after tooth extraction were evaluated using univariate and multivariate analyses. Patient characteristics such as age and gender the presence or absence of known comorbidities such as diabetes mellitus, hypertension, cerebral infarction, and alcohol consumption and perioperative diarrhea were assessed. The drug used for antithrombotic therapy, preoperative blood test results, the presence or absence of preoperative antibiotics or nonsteroidal anti-inflammatory drug (NSAID) administration, the total number of extracted teeth, and the type of surgical procedures were also evaluated. We found that the preoperative administration of antibiotics (odds ratio (OR) = 2.52), an increased prothrombin time international normalized ratio (PT-INR) value (OR = 1.94), and the extraction of multiple teeth (OR = 2.10) were significantly associated with postoperative hemorrhage. There was no significant association between postoperative hemorrhage and any other demographic factors or comorbidities, including concomitant alcohol use. We demonstrated the multivariate relationship between the risk factors and postoperative hemorrhage after tooth extraction in patients receiving oral antithrombotic therapy. Surgeons should be aware of these risks and monitor the PT-INR of anticoagulated patients.

    Springer Verlag, 2017年12月01日, Oral and Maxillofacial Surgery, 21 (4), 397 - 404, 英語

    [査読有り]

    研究論文(学術雑誌)

  • A Case Series of Fibro-Osseous Lesions of the Jaws.

    Akashi M, Matsuo K, Shigeoka M, Kakehi Y, Hasegawa T, Tachibana A, Furudoi S, Komori T

    The aim of this case series was to reveal the difficulties in diagnosing fibro-osseous lesions with radiological and histopathological examinations and quantify the potential risk of infection to fibro-osseous legions. To analyze the concordance between radiological and histopathological diagnoses, this retrospective case series included patients who were clinically diagnosed with fibro-osseous lesions via radiological findings and excluded the patients who did not undergo histopathological examinations. This study also included the patients in whom histopathological results confirmed fibro-osseous legions when preoperative radiological diagnosis did not include fibro-osseous legions. Eleven patients (three men, eight women; median age 24.5 years, range 15-57 years) were enrolled. Although radiological diagnoses of fibrous dysplasia (FD) corresponded with histopathological diagnoses in seven patients, mismatches between radiological findings and histopathological results were found in three patients. In one patient, suspected diagnosis with radiological examinations was malignant lymphoma or FD. In two patients, the histopathological differentiation between FD and ossifying fibroma (OF) was difficult. One patient had lesion recurrence which was suspected to be OF with surgical findings and postoperative course after the initial surgery. In three patients, infections of FD were found. Preoperative diagnosis of OF with radiographic feature of unilocular radiolucency is difficult. In cases in which histopathological differentiation between FD and OF is difficult, operative findings should be used because OF is often found to be well-encapsulated and easily enucleated. Bone in FD showing mixed radiolucent-radiopaque may be vulnerable to infection.

    2017年12月, Kobe J Med Sci, 63 (3), E73 - 79, 英語, 国内誌

    [査読有り]

    研究論文(学術雑誌)

  • Masaya Akashi, Toshinori Sekitani, Yumi Ohtsuki, Yasumasa Kakei, Junya Kusumoto, Takumi Hasegawa, Michinori Maeda, Noriyuki Negi, Kazunobu Hashikawa, Yasuyuki Shibuya, Satoru Takahashi, Takahide Komori

    Objective: Few studies evaluate condylar movement following mandibular reconstruction. The main objective of this study was to show that axial four-dimensional computed tomography (4DCT) could visualize bilateral protrusive condylar movement directly. We used axial 4DCT images to assess condylar protrusion in patients who underwent mandibular reconstruction. Methods: We enrolled seven healthy volunteers (median age 30 years, range 27-38 years) and seven patients (median age 65 years, range 52-80 years), who underwent mandibulectomy (segmental in five, hemi in one, marginal in one) and free flap reconstruction (using the fibula in six and the radial forearm in one). Six study subjects were instructed to masticate a cookie during the 4DCT scan (the seventh made chewing motions). The distance between the most anterior and posterior positions of the bilateral condyles on 4DCT (axial view) images was then measured and compared between controls and patients using the Manne-Whitney U-test. Results: The crosswise difference in the distances of condylar protrusion was significantly greater in patients than in the controls. Conclusion: Axial 4DCT images can visualize a bilateral condylar protrusive path. Axial 4DCT images for patients who have undergone mandibulectomy and reconstruction may be useful for evaluation of functional movement of condyles. (C) 2017 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

    CHURCHILL LIVINGSTONE, 2017年11月, JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY, 45 (11), 1778 - 1783, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Saki Hayashida, Sakiko Soutome, Souichi Yanamoto, Shigeyuki Fujita, Takumi Hasegawa, Takahide Komori, Yuka Kojima, Hironori Miyamoto, Yasuyuki Shibuya, Nobuhiro Ueda, Tadaaki Kirita, Hirokazu Nakahara, Mitsuyo Shinohara, Masahiro Umeda

    Medication-related osteonecrosis of the jaw (MRONJ) is an adverse event that may inhibit the treatment of primary disease and remarkably influence the patient's quality of life. The treatment methods for MRONJ, nonsurgical and surgical, are controversial, with no agreement as to which method provides the best outcome and should therefore be recommended. This multicenter retrospective study aimed to investigate the treatment methods and outcome in a large number of patients with MRONJ in Japan, utilizing propensity score matching analysis. A total of 361 patients with MRONJ, at eight hospitals, were registered in this study retrospectively. Various demographic and treatment-related variables were examined and analyzed to determine their correlation with the treatment outcome. After propensity score matching for treatment methods (nonsurgical versus surgical treatment), 176 patients were analyzed by logistic regression. It was shown that those with low-dose administration of an antiresorptive agent and surgical treatment had better outcomes. Furthermore, in 159 patients who underwent surgical treatment, those who underwent extensive surgery experienced significantly better treatment outcomes than those who underwent conservative surgery. This is the first study to compare treatment methods for MRONJ using propensity score matching analysis. The results indicated that extensive surgical treatment should be performed as first-choice therapy for patients with MRONJ. © 2017 American Society for Bone and Mineral Research.

    2017年10月, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 32 (10), 2022 - 2029, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • YamadaSI, OtsuruM, YanamotoS, HasegawaT, AizawaH, KamataT, YamakawaN, KohgoT, ItoA, NodaY, HiraiC, KitamuraT, OkuraM, KiritaT, UedaM, YamashitaT, OtaY, KomoriT, UmedaM, KuritaH

    OBJECTIVES: The progression level of extracapsular spread (ECS) for cervical lymph node metastasis of oral squamous cell carcinoma (OSCC) was previously divided into three types, and their relationships with the prognosis of patients were re-examined. PATIENTS AND METHODS: The Kaplan-Meier method was used to examine overall survival (OS) and relapse-free survival (RFS) curves. Prognosis factor for recurrence was analyzed with univariate and multivariate analysis. RESULTS: ECS was detected in 216 cases of OSCC and analyzed. The 5-year overall survival and RFS rates of patients with type C, which was microscopically defined as tumor invasion to perinodal fat or muscle tissue, were significantly poor at 40.6 and 37.8%, respectively. The results of a univariate analysis suggested that the prognosis of ECS in OSCC patients is associated with its progression level, particularly type C. The 5-year RFS rate of type C with tumor budding was significantly poor at 31.5%. Type C with tumor budding correlated with local and regional recurrence as well as distant metastasis. In a multivariate analysis, tumor budding was identified as an independent prognostic factor. CONCLUSIONS: These results suggest that the progression level of ECS and tumor budding are useful prognostic factors in OSCC patients. CLINICAL RELEVANCE: This study indicated that the progression level and tumor budding of ECS for cervical lymph node metastasis were useful prognostic factors in OSCC patients.

    2017年10月, Clin Oral Investig, 22 (3), 1311 - 1318, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Saki Hayashida, Sakiko Soutome, Souichi Yanamoto, Shigeyuki Fujita, Takumi Hasegawa, Takahide Komori, Yuka Kojima, Hironori Miyamoto, Yasuyuki Shibuya, Nobuhiro Ueda, Tadaaki Kirita, Hirokazu Nakahara, Mitsuyo Shinohara, Masahiro Umeda

    Medication-related osteonecrosis of the jaw (MRONJ) is an adverse event that may inhibit the treatment of primary disease and remarkably influence the patient's quality of life. The treatment methods for MRONJ, nonsurgical and surgical, are controversial, with no agreement as to which method provides the best outcome and should therefore be recommended. This multicenter retrospective study aimed to investigate the treatment methods and outcome in a large number of patients with MRONJ in Japan, utilizing propensity score matching analysis. A total of 361 patients with MRONJ, at eight hospitals, were registered in this study retrospectively. Various demographic and treatment-related variables were examined and analyzed to determine their correlation with the treatment outcome. After propensity score matching for treatment methods (nonsurgical versus surgical treatment), 176 patients were analyzed by logistic regression. It was shown that those with low-dose administration of an antiresorptive agent and surgical treatment had better outcomes. Furthermore, in 159 patients who underwent surgical treatment, those who underwent extensive surgery experienced significantly better treatment outcomes than those who underwent conservative surgery. This is the first study to compare treatment methods for MRONJ using propensity score matching analysis. The results indicated that extensive surgical treatment should be performed as first-choice therapy for patients with MRONJ. (C) 2017 American Society for Bone and Mineral Research.

    WILEY, 2017年10月, JOURNAL OF BONE AND MINERAL RESEARCH, 32 (10), 2022 - 2029, 英語

    [査読有り]

    研究論文(学術雑誌)

  • 早期舌扁平上皮癌における頸部後発転移の新たな予測因子の検討

    山川 延宏, 桐田 忠昭, 梅田 正博, 柳本 惣市, 太田 嘉英, 大鶴 光信, 大倉 正也, 相川 友直, 栗田 浩, 山田 慎一, 古森 孝英, 長谷川 巧実, 上田 倫弘

    (一社)日本癌治療学会, 2017年10月, 日本癌治療学会学術集会抄録集, 55回, PS - 1, 日本語

  • インプラント周囲に放射線性顎骨壊死を生じ保存的に治療した1例

    明石 昌也, 鰐渕 聡, 岩田 英治, 筧 康正, 長谷川 巧実, 鈴木 泰明, 古森 孝英

    頭頸部癌に対する放射線治療は重要な治療法であるが、重篤な合併症の一つに放射線性顎骨壊死がある。最も良く知られた発症の誘因は、抜歯などの外科的侵襲である。今回、われわれはインプラント周囲に放射線性顎骨壊死を生じ、長期に渡る保存的治療ののちに腐骨分離した1例を経験したので報告する。症例は68歳の女性。左側顎下腺腺様嚢胞癌の診断のもと、手術と術後化学放射線療法が施行された。放射線治療から3年後、右側下顎に放射線治療前より埋入されていたインプラント周囲溝からの排膿を伴う感染所見を認め、当科を受診した。インプラント周囲の放射線性顎骨壊死の診断のもと、局所の洗浄や抗菌薬経口投与などの保存的治療を継続し、放射線治療から5年後インプラントと腐骨が一塊に分離したため、局所麻酔下に除去した。放射線性顎骨壊死は多くの場合難治性であり、治療法は随伴症状の重篤度や全身状態などを総合的に判断し選択する必要がある。予防にはインプラント周囲の衛生状態の維持を目的とした放射線治療後の口腔衛生管理がきわめて重要である。(著者抄録)

    (公社)日本顎顔面インプラント学会, 2017年08月, Japanese Journal of Maxillo Facial Implants, 16 (2), 75 - 80, 日本語

    [査読有り]

    研究論文(学術雑誌)

  • Yuka Kojima, Souichi Yanamoto, Masahiro Umeda, Yumiko Kawashita, Izumi Saito, Takumi Hasegawa, Takahide Komori, Nobuhiro Ueda, Tadaaki Kirita, Shin-ichi Yamada, Hiroshi Kurita, Yasuko Senga, Yasuyuki Shibuya, Hiroshi Iwai

    Objective. Osteoradionecrosis of the jaw is a serious late adverse event in patients with head and neck cancer undergoing radiotherapy. The aim of this study is to investigate the relationship between dental status and development of osteoradionecrosis. Study Design. Multicenter, retrospective observational study. A total of 392 patients with head and neck cancer who underwent radiotherapy were investigated for correlations between the development of osteoradionecrosis and various factors. The cumulative occurrence rate of osteoradionecrosis was calculated by the Kaplan-Meier method and analyzed by Cox regression and log-rank test. Results. Osteoradionecrosis developed in 30 of 392 patients. In 23 patients, osteoradionecrosis occurred in the mandibular molar region. A univariate analysis showed that oral or oropharyngeal cancer, jaw radiotherapy dose exceeding 50 Gy, periapical periodontitis, and tooth extraction after radiotherapy were significantly correlated with the occurrence of osteoradionecrosis. Among these, oral and oropharyngeal cancer, periapical periodontitis, and tooth extraction after radiotherapy were significant independent risk factors by multivariate analysis. Further, caries that occurred after radiotherapy and progressed rapidly, resulting in periapical periodontitis, carious stump, or extraction, was a major cause of osteoradionecrosis. Conclusion. Extraction of mandibular molars with periapical periodontitis before radiotherapy and strict dental management after radiotherapy may reduce the risk of osteoradionecrosis.

    ELSEVIER SCIENCE INC, 2017年08月, ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY, 124 (2), 139 - 145, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Sakiko Soutome, Souichi Yanamoto, Madoka Funahara, Takumi Hasegawa, Takahide Komori, Shin-ichi Yamada, Hiroshi Kurita, Chika Yamauchi, Yasuyuki Shibuya, Yuka Kojima, Hirokazu Nakahara, Takahiko Oho, Masahiro Umeda

    The aim of this study was to investigate the effectiveness of oral care in prevention of postoperative pneumonia associated with esophageal cancer surgery. Postoperative pneumonia is a severe adverse event associated with esophageal cancer surgery. It is thought to be caused by aspiration of oropharyngeal fluid containing pathogens. However, the relationship between oral health status and postoperative pneumonia has not been well investigated. This study included 539 patients with esophageal cancer undergoing surgery at 1 of 7 university hospitals. While 306 patients received perioperative oral care, 233 did not. Various clinical factors as well as occurrence of postoperative pneumonia were retrospectively evaluated. Propensity-score matching was performed to minimize selection biases associated with comparison of retrospective data between the oral care and control groups. Factors related to postoperative pneumonia were analyzed by logistic regression analysis. Of the original 539 patients, 103 (19.1%) experienced postoperative pneumonia. The results of multivariate analysis of the 420 propensity score-matched patients revealed longer operation time, postoperative dysphagia, and lack of oral care intervention to be significantly correlated with postoperative pneumonia. The present findings demonstrate that perioperative oral care can reduce the risk of postoperative pneumonia in patients undergoing esophageal cancer surgery.

    LIPPINCOTT WILLIAMS & WILKINS, 2017年08月, MEDICINE, 96 (33), e7436, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Yasumasa Kakei, Shun Teraoka, Masaya Akashi, Takumi Hasegawa, Takahide Komori

    The benefits of epidermal growth factor receptor (EGFR) targeting in the treatment of head and neck cancer, have been documented. However, a minority of patients with head and neck cancer are unresponsive to EGFR targeting therapies. The present study evaluated the effects and limitations of an EGFR inhibitor on oral squamous cell carcinoma cells, particularly on cell-cell junctions mediated by epithelial (E)-cadherin. HSC-3 oral squamous cell carcinoma cells were treated with the EGFR inhibitor, AG1478 (0, 0.5, 2, 10 and 50 mu M), and the effects of EGFR inhibition in HSC-3 cells were evaluated by wound healing assays, E-cadherin immunostaining and measurement of transepithelial electrical resistance in vitro. It was observed that treatment of oral squamous cell carcinoma cells with AG1478 suppressed cell motility, altered cell morphology and increased the number of cell-cell junctions compared with untreated control cells. Knockdown of EGFR induced a similar phenotype to that observed by the inhibition of EGFR. Furthermore, in oral squamous cell carcinoma cells treated with high-dose EGFR inhibitor (50 mu M), the small number of cells that survived formed cell-cell junctions that were positive for E-cadherin expression. In cells treated with low concentrations of EGFR inhibitor (2 mu M), recovery of epithelial properties was observed. The retention of E-cadherin expression in cells that survived high-dose EGFR inhibitor treatment may be a survival mechanism of cancer cells.

    SPANDIDOS PUBL LTD, 2017年08月, EXPERIMENTAL AND THERAPEUTIC MEDICINE, 14 (2), 953 - 960, 英語

    [査読有り]

    研究論文(学術雑誌)

  • T. Hasegawa, A. Kawakita, N. Ueda, R. Funahara, A. Tachibana, M. Kobayashi, E. Kondou, D. Takeda, Y. Kojima, S. Sato, S. Yanamoto, H. Komatsubara, M. Umeda, T. Kirita, H. Kurita, Y. Shibuya, T. Komori

    The Summary Root amputation, extraction of a single tooth, bone loss or severe tooth mobility, and an unclosed wound were significantly associated with increased risk of developing medication-related osteonecrosis of the jaw (MRONJ). We recommend a minimally traumatic extraction technique, removal of any bone edges, and mucosal wound closure as standard procedures in patients receiving bisphosphonates. Introduction Osteonecrosis of the jaws can occur following tooth extraction in patients receiving bisphosphonate drugs. Various strategies for minimizing the risk of MRONJ have been advanced, but no studies have comprehensively analyzed the efficacy of factors such as primary wound closure, demographics, and drug holidays in reducing its incidence. The purpose of this study was to retrospectively investigate the relationships between these various risk factors after tooth extraction in patients receiving oral bisphosphonate therapy. Methods Risk factors for MRONJ after tooth extraction were evaluated using univariate and multivariate analysis. All patients were investigated with regard to demographics; type and duration of oral bisphosphonate use; whether they underwent a discontinuation of oral bisphosphonates before tooth extraction (drug holiday), and the duration of such discontinuation; and whether any additional surgical procedures (e.g., incision, removal of bone edges, root amputation) were performed. Results We found that root amputation (OR = 6.64), extraction of a single tooth (OR = 3.70), bone loss or severe tooth mobility (OR = 3.60), and an unclosed wound (OR = 2.51) were significantly associated with increased risk of developing MRONJ. Conclusions We recommend a minimally traumatic extraction technique, removal of any bone edges, and mucosal wound closure as standard procedures in patients receiving bisphosphonates. We find no evidence supporting the efficacy of a pre-extraction short-term drug holiday from oral bisphosphonates in reducing the risk of MRONJ.

    SPRINGER LONDON LTD, 2017年08月, OSTEOPOROSIS INTERNATIONAL, 28 (8), 2465 - 2473, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Souichi Yanamoto, Takumi Hasegawa, Satoshi Rokutanda, Sayaka Komori, Akira Tachibana, Yuka Kojima, Yoshito Koyama, Yasuyuki Shibuya, Hiroshi Kurita, Takahide Komori, Masahiro Umeda

    Purpose: To identify the risk factors affecting hemorrhage after tooth extraction in patients receiving antiplatelet therapy, this study investigated the relation between various factors and hemorrhage events after tooth extraction. Patients and Methods: The records of 264 patients receiving antiplatelet therapy who underwent tooth extraction were retrospectively reviewed from 6 institutions belonging to the Japanese Study Group of Cooperative Dentistry with Medicine. Demographic information, hemorrhage events after tooth extraction, the presence or absence of comorbidities, antiplatelet agent, the use of preoperative antibiotics or nonsteroidal anti-inflammatory drugs, number of teeth extracted, serum creatinine level, estimated glomerular filtration rate, and alanine transaminase level were assessed. Risk factors for hemorrhage after tooth extraction were evaluated by univariate and multivariate analyses. Results: The study population of 264 patients consisted of 153 men and 111 women with a mean age of 73.6 years (range, 24 to 96 yr). Six hundred ninety-four teeth were extracted (mean, 2.6 +/- 2.3 teeth per patient). In patients receiving antiplatelet therapy, the frequency of hemorrhage after tooth extraction, including mild and self-controlled hemorrhages, was 17.4%. Univariate analysis showed that serum creatinine level and dual antiplatelet therapy were correlated with hemorrhage after tooth extraction (P = .001 and P = .049, respectively). Only serum creatinine was identified as an independent risk factor for hemorrhage after tooth extraction in patients receiving antiplatelet therapy (P = .037). Conclusions: The risk of hemorrhage after tooth extraction is increased in patients receiving dual antiplatelet therapy with or without chronic kidney disease. Local hemostatic treatments, such as at least suturing, are recommended. (C) 2017 American Association of Oral and Maxillofacial Surgeons

    W B SAUNDERS CO-ELSEVIER INC, 2017年07月, JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 75 (7), 1338 - 1343, 英語

    [査読有り]

    研究論文(学術雑誌)

  • AkashiM, TeraokaS, KakeiY, KusumotoJ, HasegawaT, MinamikawaT, HashikawaK, KomoriT

    BACKGROUND: This study aimed to evaluate posttreatment soft-tissue changes in patients with oral cancer with computed tomography (CT). To accomplish that purpose, a scoring system was established, referring to the criteria of lower leg lymphedema (LE). METHODS AND RESULTS: One hundred and six necks in 95 patients who underwent oral oncologic surgery with neck dissection (ND) were analyzed retrospectively using routine follow-up CT images. A two-point scoring system to evaluate soft-tissue changes (so-called "LE score") was established as follows: Necks with a "honeycombing" appearance were assigned 1 point. Necks with "taller than wide" fat lobules were assigned 1 point. Necks with neither appearance were assigned 0 points. Comparisons between patients with LE score ≥1 and LE score = 0 at 6 months postoperatively were performed using the Fisher exact test for discrete variables and the Mann-Whitney U test for continuous variables. Univariate predictors associated with posttreatment changes (i.e., LE score ≥1 at 6 months postoperatively) were entered into a multivariate logistic regression analysis. Values of p < 0.05 were considered to indicate statistical significance. The occurrence of the posttreatment soft-tissue changes was 32%. Multivariate logistic regression analysis showed that postoperative radiation therapy (RT) and bilateral ND were potential risk factors of posttreatment soft-tissue changes on CT images. CONCLUSIONS: Sequential evaluation of "honeycombing" and the "taller than wide" appearances on routine follow-up CT revealed the persistence of posttreatment soft-tissue changes in patients who underwent oral cancer treatment, and those potential risk factors were postoperative RT and bilateral ND.

    2017年07月, Lymphat Res Biol, 16 (2), 147 - 153, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • ARONJの新たな医科歯科連携 薬剤関連顎骨壊死(MRONJ)の治療成績に影響する因子に関する多施設共同後ろ向き観察研究

    林田 咲, 柳本 惣市, 藤田 茂之, 長谷川 巧実, 古森 孝英, 兒島 由佳, 上田 順宏, 桐田 忠昭, 宮本 大模, 渋谷 恭之, 篠原 光代, 中原 寛和, 梅田 正博

    (NPO)日本口腔科学会, 2017年07月, 日本口腔科学会雑誌, 66 (2), 81 - 82, 日本語

  • 早期舌癌における再発予測因子としてのTumor Buddingの検討

    山川 延宏, 桐田 忠昭, 梅田 正博, 柳本 惣市, 太田 嘉英, 大鶴 光信, 大倉 正也, 相川 友直, 栗田 浩, 山田 慎一, 古森 孝英, 長谷川 巧実, 上田 倫弘

    (NPO)日本口腔科学会, 2017年07月, 日本口腔科学会雑誌, 66 (2), 110 - 111, 日本語

  • ARONJの新たな医科歯科連携 抜歯と骨吸収抑制薬関連性顎骨壊死に関する多施設共同後ろ向き研究 抜歯前休薬の有無と術中処置について

    長谷川 巧実, 川北 晃子, 上田 順宏, 橘 進彰, 小林 正樹, 近藤 英司, 小松原 秀紀, 兒島 由佳, 佐藤 隼, 梅田 正博, 桐田 忠昭, 栗田 浩, 渋谷 恭之, 古森 孝英

    (NPO)日本口腔科学会, 2017年07月, 日本口腔科学会雑誌, 66 (2), 81 - 81, 日本語

  • 武田大介, 長谷川巧実, 日向信之, 重岡学, 小林正樹, 小松原秀紀, 南川勉, 古森孝英

    腎盂尿管癌の口腔内への転移は極めてまれである。われわれは、腎盂尿管癌が下顎関節突起に転移した1例を経験したので報告する。症例は70歳男性で、右顎関節部の自発痛を主訴としてわれわれの診療科を受診した。パノラマX線写真で右下顎関節突起に瀰漫性のX線透過像が、またCT画像とMR画像で同部に辺縁境界不明瞭な腫瘤影が確認された。一方で男性は、当院泌尿器科で左腎盂癌の診断を受けていた。重複癌の除外診断を得るために、われわれは、右下顎関節突起の組織検査を行い、泌尿器科医は、左腎尿管全摘出術を行った。両者の病理組織学的診断より、腎盂扁平上皮癌の口腔内転移と診断された。患者は姑息的な全身化学療法を受けたが、原発腫瘍と全身転移の制御は不可能であった。(著者抄録)

    (一社)日本口腔腫瘍学会, 2017年06月, 日本口腔腫瘍学会誌, 29 (2号), 45 - 51, 日本語

    [査読有り]

    研究論文(学術雑誌)

  • Single-stage reconstruction for buccal mucosa tumor resection including the labial commissure using a facial artery musculomucosal flap and a vermilion advancement flap

    SakakibaraA, MatsumotoK, HasegawaT, MinamikawaT, KomoriT

    2017年06月, J Surg Case Rep, 2017 (6), rjx108, 英語

    [査読有り]

    研究論文(学術雑誌)

  • UehaT, OeK, MiwaM, HasegawaT, NishimotoH, LeeSY, NiikuraT, KurosakaM, KurodaR, SakaiY

    Endurance exercise generates CO2 via aerobic metabolism; however, its role remains unclear. Exogenous CO2 by transcutaneous delivery promotes muscle fibre-type switching to increase endurance power in skeletal muscles. Here we determined the performance of rats running in activity wheels with/without transcutaneous CO2 exposure to clarify its effect on endurance exercise and recovery from muscle fatigue. Rats were randomised to control, training and CO2 groups. Endurance exercise included activity-wheel running with/without transcutaneous CO2 delivery. Running performance was measured after exercise initiation. We also analysed changes in muscle weight and muscle fibres in the tibialis anterior muscle. Running performance improved over the treatment period in the CO2 group, with a concomitant switch in muscle fibres to slow-type. The mitochondrial DNA content and capillary density in the CO2 group increased. CO2 was beneficial for performance and muscle development during endurance exercise: it may enhance recovery from fatigue and support anabolic metabolism in skeletal muscles.

    2017年06月, J Physiol Sci, 68 (4), 463 - 470, 英語, 国内誌

    [査読有り]

    研究論文(学術雑誌)

  • Izumi Saito, Takumi Hasegawa, Eiji Iwata, Natsuki Yonezawa, Satomi Arimoto, Daisuke Takeda, Akiko Sakakibara, Masaya Akashi, Tsutomu Minamikawa, Takahide Komori

    Objective Previous reports regarding postoperative drainage have documented complications associated with the drainage volume (DV). However, there is little information available concerning the postoperative and operative factors that influence postoperative DV. In this study, we retrospectively investigated the relationship between postoperative drainage and various risk factors in patients undergoing head and neck surgery for oral cancer. Methods This study included 136 patients (88 males, 48 females, mean age 67.2 ± 12.9 years) who underwent head and neck surgery for oral cancer. We retrospectively investigated the following variables: age, sex, subsite, medical history, surgical procedure, operative time, blood loss, duration of drain retention, DV, and postoperative complications. Results DV after reconstruction with a pectoral major musculocutaneous flap was significantly higher than DV after reconstruction with a forearm flap (p <  0.05). DV was significantly greater in cases involving a large amount of blood loss or a long operative time (p <  0.05). DV was significantly greater after modified radical neck dissection than after supraomohyoid or submandibular neck dissection (p <  0.05). DV was significantly greater in patients receiving antithrombotic therapy than in patients without (p <  0.05). Multiple regression analysis revealed that total DV was positively correlated with older age, antithrombotic therapy, type of surgery (advanced surgery), and type of neck dissection (wide range). Conclusions DV was greater in those with older age, antithrombotic therapy, advanced surgery, and wide-ranging neck dissection. Therefore, clinicians should consider these risk factors and pay special attention to the postoperative management of drains in such cases.

    Elsevier Ltd, 2017年05月01日, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, 29 (3), 217 - 221, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Takumi Hasegawa, Souichi Yanamoto, Mitsunobu Otsuru, Shin-ichi Yamada, Tsutomu Minamikawa, Takashi Shigeta, Tomofumi Naruse, Takatsugu Suzuki, Masashi Sasaki, Yoshihide Ota, Masahiro Umeda, Takahide Komori

    Background The purpose of this study was to investigate the feasibility of postoperative concomitant chemoradiotherapy (CRT) with cisplatin (CDDP), and compare the prognosis in 3 groups—without postoperative therapy (S-only), with radiotherapy (RT) alone (S+RT), and with CRT (S+CRT)—in oral squamous cell carcinoma (OSCC) patients at high risk of recurrence. Methods Clinicopathologic data and treatment modality were investigated. Endpoints evaluated were locoregional control (LRC), relapse-free survival, overall survival (OS), and type of recurrence. Results The S+CRT group was associated with a better LRC rate than the S-only (P <  .001) and S+RT groups (P = .044). However, there was no significant difference in OS rates between the S+RT and S+CRT groups. Conclusion The addition of concomitant CDDP to postoperative RT improved LRC. However, there may be no benefit from the addition of concomitant CDDP to postoperative RT for improvement of distant metastasis and OS rates in OSCC patients.

    Mosby Inc., 2017年05月01日, Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 123 (5), 524 - 530, 英語

    [査読有り]

    研究論文(学術雑誌)

  • 神経症状を伴った下顎放射線性顎骨壊死における下歯槽神経の病理組織学的研究

    明石 昌也, 楠元 順哉, 長谷川 巧実, 南川 勉, 橋川 和信, 古森 孝英

    (一社)日本頭頸部癌学会, 2017年05月, 頭頸部癌, 43 (2), 189 - 189, 日本語

  • Daisuke Takeda, Takumi Hasegawa, Takeshi Ueha, Eiji Iwata, Risa Harada, Akiko Sakakibara, Teruya Kawamoto, Tsutomu Minamikawa, Yoshitada Sakai, Takahide Komori

    Background/Aim: Cancer stem cells are suspected to contribute to malignancy in tumors. Hypoxia affects cell differentiation and induces stem-cell-like characteristics in malignancies. Induced pluripotency was demonstrated in mouse fibroblasts by reprogramming with four transcriptional factors: Oct3/4, Sox2, c-Myc, and Klf4. Conversely, oncogenic transformations frequently express transcriptional factors and Nanog. Therefore, cancer cells present some similarities with induced pluripotent stem (iPS) cells. Materials and Methods: We investigated the expression of iPS-related genes in vitro and in clinical samples to identify their relationships with hypoxia and tumorigenesis. Results: Oral squamous cell carcinoma (SCC) cells were used to show that expression levels of Oct3/4, Sox2, and Nanog were significantly increased in hypoxic condition in vitro and in moderately-and poorly-differentiated samples. Conclusion: We propose that Oct3/4, Sox2 and Nanog are associated with tumor hypoxia characterized in oral SCC and that these factors may also contribute to the undifferentiated potency observed in oral SCC clinically.

    INT INST ANTICANCER RESEARCH, 2017年03月, Anticancer Research, 37 (3), 1075 - 1082, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • T. Hasegawa, S. Kawabata, D. Takeda, E. Iwata, I. Saito, S. Arimoto, A. Kimoto, M. Akashi, H. Suzuki, T. Komori

    The purpose of this study was to retrospectively investigate the outcomes of Branemark System Mk III TiUnite/Groovy implants placed in patients at Kobe University Hospital. Various risk factors for implant failure, including mechanical coupling, were investigated by univariate and multivariate analysis. The predictive variables investigated included age, sex, smoking habit, general health, history of radiation therapy, application of a dentomaxillary prosthesis, type of prosthesis, use of alveolar bone augmentation, site of implant insertion, mechanical coupling between implants, and the length and diameter of the implants. Of the 907 implants investigated, only 23 were unsuccessful; the overall survival rate was 96.7%. Increased age, radiation therapy, application of a removable prosthesis or dentomaxillary prosthesis, lack of mechanical coupling between implants, and shorter implants (<= 8.5 mm) were significant risk factors for implant failure according to univariate analysis (P < 0.05). Multivariate analysis identified a significant association (P < 0.05) between dental implant failure and a lack of mechanical coupling between implants (odds ratio 6.88) and shorter implants (<= 8.5 mm) (odds ratio 3.43). The findings of this study demonstrated multivariate relationships between various risk factors and dental implant failure.

    CHURCHILL LIVINGSTONE, 2017年02月, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 46 (2), 267 - 273, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Akiko Sakakibara, Shunsuke Sakakibara, Junya Kusumoto, Daisuke Takeda, Takumi Hasegawa, Masaya Akashi, Tsutomu Minamikawa, Kazunobu Hashikawa, Hiroto Terashi, Takahide Komori

    Objectives Transient receptor potential cation channel (subfamily V, members 1-4) (TRPV1-4) are expressed in skin and neurons and activated by external stimuli in normal mucosae of all oral cavity sites. The oral cavity is exposed to various stimuli, including temperature, mechanical stimuli, chemical substances, and changes in pH, and, notably, the risk factors for oncogenic transformation in oral squamous epithelium are the same as the external stimuli received by TRPV1-4 receptors. Hence, we examined the relationship between oral squamous cell carcinoma (SCC) and TRPV1-4 expression. Materials and Methods Oral SCC patients (n = 37) who underwent surgical resection were included in this study. We investigated the expression of TRPV1-4 by immunohistochemical staining and quantification of TRPV1-4 mRNA in human oral mucosa. In addition, we compared the TRPV1-4 levels in mucosa from patients with SCC to those in normal oral mucosa. Results The receptors were expressed in oral mucosa at all sites (tongue, buccal mucosa, gingiva, and oral floor) and the expression was stronger in epithelia from patients with SCC than in normal epithelia. Furthermore, alcohol consumption and tobacco use were strongly associated with the occurrence of oral cancer and were found to have a remarkable influence on TRPV1-4 receptor expression in normal oral mucosa. In particular, patients with a history of alcohol consumption demonstrated significantly higher expression levels. Conclusion Various external stimuli may influence the behavior of cancer cells. Overexpression of TRPV1-4 is likely to be a factor in enhanced sensitivity to external stimuli. These findings could contribute to the establishment of novel strategies for cancer therapy or prevention.

    PUBLIC LIBRARY SCIENCE, 2017年01月, PLOS ONE, 12 (1), e0169723, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Takumi Hasegawa, Yasuyuki Shibuya, Daisuke Takeda, Eiji Iwata, Izumi Saito, Yasumasa Kakei, Akiko Sakakibara, Masaya Akashi, Tsutomu Minamikawa, Takahide Komori

    Purpose: The objectives of this study were to retrospectively describe the characteristics and outcomes of patients with oral squamous cell carcinoma (OSCC) with level IV/V metastases, and to evaluate the multivariate relationships among potential risk factors for metastasis and prognosis. Materials and methods: We evaluated 291 patients (178 men and 113 women; mean age, 65.9 +/- 13.5 years). Clinicopathological data, time of development of level IV/V metastases, and clinical course were investigated. Results: Twenty-three patients (7.9%) developed level IV/V metastases. The 3-year overall survival rates when level IV/V metastasis first developed were 27.3% upon initial treatment, 57.1% when metachronous neck metastasis developed, and 40.0% when the tumor recurred. Oral tongue tumor subsite, high N staging, neck dissection when metachronous neck metastasis developed, as well as recurrence were independent risk factors for level IV/V metastasis. Conclusion: We demonstrate here the multivariate relationships among the risk factors indicated above for level IV/V metastasis and their prognostic significance for patients with OSCC. Oral tongue tumors, high N staging, and neck dissection upon the occurrence of metachronous neck metastasis or recurrence were risk factors for level IV/V metastasis and positive extracapsular spread, presence of multiple lymph metastases, and moderate or poor differentiation were poor prognostic factors. (C) 2016 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

    CHURCHILL LIVINGSTONE, 2017年01月, JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY, 45 (1), 145 - 149, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Soutome Sakiko, Yanamoto Souichi, Funahara Madoka, Hasegawa Takumi, Komori Takahide, Yamada Shin-ichi

    AMER SOC CLINICAL ONCOLOGY, 2017年, Medicine, 96 (e7436), 英語

    [査読有り]

  • Masaya Akashi, Yujiro Hiraoka, Takumi Hasegawa, Takahide Komori

    Objective: This retrospective study aimed to report the incidence of neurosensory complications after third molar extraction and also to identify current problems and discuss appropriate management of these complications. Method: Patients who underwent extraction of deeply impacted mandibular third molars under general anesthesia were included. The following epidemiological data were retrospectively gathered from medical charts: type of neurosensory complication, treatment for complication, and outcome. Results: A total 369 mandibular third molars were extracted in 210 patients under general anesthesia during this study period. Thirty-one of the 369 teeth (8.4%) in 31 patients had neurosensory complications during the first postoperative week resulting from inferior alveolar nerve damage. Neurosensory complications lasting from 1 to 3 months postoperatively included 17 cases of hypoesthesia and 8 of dysesthesia in 19 patients. Five cases of hypoesthesia and 4 of dysesthesia in 5 patients persisted over 1 year postoperatively. Sixteen of 369 teeth (4.3%) in 16 patients had persistent neurosensory complications after third molar extraction under general anesthesia. Stellate ganglion block was performed in 4 patients. Early initiation of stellate ganglion block (within 2 weeks postoperatively) produced better outcomes than late stellate ganglion block (over 6 months postoperatively). Conclusion: Refractory neurosensory complications after third molar extraction often combine both hypoesthesia and dysesthesia. Current problems in diagnosis and treatment included delayed detection of dysesthesia and the lack of uniform timing of stellate ganglion block. In the future, routinely inquiring about dysesthesia and promptly providing affected patients with information about stellate ganglion block might produce better outcomes.

    Bentham Science Publishers B.V., 2016年12月01日, Open Dentistry Journal, 10, 728 - 732, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Okura M, Yanamoto S, Umeda M, Otsuru M, Ota Y, Kurita H, Kamata T, Kirita T, Yamakawa N, Yamashita T, Ueda M, Komori T, Hasegawa T, Aikawa T, Japan Oral, Oncology Group

    A multi-institutional study was undertaken to determine whether mandibular canal (MC) invasion and mandibular medullary bone invasion are independent factors in lower gingival squamous cell carcinoma (SCC). A total of 345 patients with lower gingival SCC were retrospectively reviewed. Mandibular bone invasion was categorized into three types; no bone invasion; invasion through cortical bone (medullary); and MC invasion. The overall survival rate and factors affecting local, regional, and distant failures were assessed by Cox proportional hazards regression analysis and Kaplan-Meier estimates. Bone invasion was present in 201 (58%) patients, of whom 107 (31%) had medullary invasion and 94 (27%) had MC invasion. Using the International Union Against Cancer (UICC) staging system and American Joint Committee on Cancer (AJCC) system, 171 (50%) patients were classified as T4a. When the bone invasion criteria were excluded from the UICC/AJCC system definition, 152 T4a tumors were downstaged and reclassified to T1 in 12 (3%), to T2 in 98 (28%), and to T3 in 42 (12%). In Cox multivariate analysis, MC invasion was an independent predictor of overall survival but medullary bone invasion was not. Medullary bone invasion was an independent variable for distant control. The current T staging system has restricted prognostic utility. The authors recommend a modified T staging system, whereby tumors with MC invasion instead of medullary bone invasion are classified as T4a, and tumors are first classified as T1 to T3 based on size and then upstaged by one T classification in the presence of medullary invasion.

    2016年12月, Cancer medicine, 5 (12), 3378 - 3385, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • 当科におけるインプラント埋入症例と喪失リスクに関する臨床的検討

    片岡 侑嗣, 長谷川 巧実, 綿越 健太, 浅井 雅敏, 有本 智美, 明石 昌也, 鈴木 泰明, 古森 孝英

    (公社)日本顎顔面インプラント学会, 2016年11月, Japanese Journal of Maxillo Facial Implants, 15 (3), 218 - 218, 日本語

  • T1-2N0M0舌扁平上皮癌の検討

    大鶴 光信, 太田 嘉英, 柳本 惣市, 大倉 正也, 梅田 正博, 桐田 忠明, 栗田 浩, 上田 倫弘, 長谷川 巧実, 柴原 孝彦, 野口 忠秀, 野口 一馬, 山下 善弘, 大廣 洋一, 内藤 博之

    (一社)日本癌治療学会, 2016年10月, 日本癌治療学会学術集会抄録集, 54回, PS - 2, 日本語

  • Masaya Akashi, Kazunobu Hashikawa, Hiroyuki Takasu, Kazuhiro Watanabe, Junya Kusumoto, Akiko Sakakibara, Takumi Hasegawa, Tsutomu Minamikawa, Takahide Komori

    Purpose: This study aimed to compare the size of skin paddles, the postoperative course, and donor site complications between primary closure and skin grafts of the free fibula flap donor site. Methods: Thirty-five consecutive patients were enrolled. Medical records were retrospectively reviewed for risk factors for delayed healing, size of skin paddles, time to resumption of gait with a mobility aid and self-ambulation, early donor site morbidity, and late donor site complaints. Results: The harvested skin paddles were significantly wider in the skin graft group than in the primary closure group (P = 0.02), with no difference in length (P = 0.1). The difference in time to resuming gait with a mobility aid was also significant (P = 0.01), but not the time to self-ambulation (P = 0.9). Two early donor site morbidities (5.7 %) and 12 late donor site complaints (34.3 %) were found. No significant difference in the incidence of early donor site morbidity was observed between two groups. Occurrence of late donor site complaints was not affected by any risk factors. Conclusions: The width of the harvested skin paddle, but not the length, is one of factors involved in donor site closure. Resumption of gait with a mobility aid, but not self-ambulation, may be delayed in skin graft patients.

    Springer Verlag, 2016年09月01日, Oral and Maxillofacial Surgery, 20 (3), 233 - 237, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Sakiko Soutome, Souichi Yanamoto, Madoka Funahara, Takumi Hasegawa, Takahide Komori, Takahiko Oho, Masahiro Umeda

    Background: Post-operative pneumonia is a frequent and possibly fatal complication of esophagectomy and is likely caused by aspiration of oropharyngeal fluid that contains pathogenic micro-organisms. We conducted a multi-center retrospective study to investigate the preventive effect of oral health care on post-operative pneumonia among patients with esophageal cancer who underwent esophagectomy. Methods: A total of 280 patients underwent esophagectomy at three university hospitals. These patients were divided retrospectively into those who received pre-operative oral care from dentists and dental hygienists (oral care group; n = 173) and those who did not receive such care (control group; n = 107). We evaluated the correlations between the occurrence of post-operative pneumonia and 18 predictive variables (patient factors, tumor factors, treatment factors, and pre-operative oral care) using the chi(2) test and logistic regression analysis. The differences of mean hospital days and mortality rate in both groups were analyzed by the Student t-test. Results: Age, post-operative dysphagia, and absence of pre-operative oral care were correlated significantly with post-operative pneumonia in the univariable analysis. Multivariable analysis revealed that diabetes mellitus, postoperative dysphagia, and the absence of pre-operative oral care were independent risk factors for post-operative pneumonia. The mean hospital stay and mortality rate did not differ between the oral care and control groups. Conclusion: Pre-operative oral care may be an effective and easy method to prevent post-operative pneumonia in patients who are undergoing esophagectomy.

    MARY ANN LIEBERT, INC, 2016年08月, SURGICAL INFECTIONS, 17 (4), 479 - 484, 英語

    研究論文(学術雑誌)

  • 塩屋園敦, 立石千鶴, 長谷川巧実, 竹内純一郎, 鈴木泰明, 古土井春吾, 古森孝英, 神戸大学医学部附属病院歯科口腔外科矯正歯科診療班

    2016年08月, 日本顎変形症学会雑誌, 26 (3号), 243 - 254, 日本語

    [査読有り]

    研究論文(学術雑誌)

  • Daisuke Takeda, Takumi Hasegawa, Takeshi Ueha, Akiko Sakakibara, Teruya Kawamoto, Tsutomu Minamikawa, Yoshitada Sakai, Takahide Komori

    BackgroundMitochondrial dysfunction and altered respiration have long been suspected to affect the development and progression of cancer. Although quantitative changes in mitochondrial DNA (mtDNA) have been reported in head and neck squamous cell carcinoma (SCC), differences in mtDNA copy numbers between normal and cancerous tissues from same patients have not been assessed. MethodsWe compared mtDNA copy numbers and expressions of peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1) and mitochondrial transcription factor A (TFAM) between normal mucous membrane and cancerous tissues resected from 35 patients with oral SCC, using TaqMan quantitative real-time polymerase chain reaction (PCR) and immunohistochemical staining. ResultsWe found mtDNA copy numbers and expressions of PGC-1 and TFAM were decreased in cancerous tissues compared with normal tissues from the same patients. ConclusionThe PGC-1-TFAM mitochondrial pathway may be associated with malignant potential in human oral SCC, and could be an attractive therapeutic target. (c) 2016 Wiley Periodicals, Inc. Head Neck 38:1170-1175, 2016

    WILEY, 2016年08月, HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 38 (8), 1170 - 1175, 英語

    [査読有り]

    研究論文(学術雑誌)

  • 抗血栓療法患者の抜歯後出血危険因子についての多施設共同研究

    柳本 惣市, 長谷川 巧実, 小守 紗也華, 渋谷 恭之, 橘 進彰, 兒島 由佳, 小山 吉人, 栗田 浩, 古森 孝英, 梅田 正博

    (NPO)日本口腔科学会, 2016年07月, 日本口腔科学会雑誌, 65 (2), 176 - 176, 日本語

  • 当科における埋伏智歯抜歯後神経系合併症に対する治療法の現状

    平岡 佑二郎, 明石 昌也, 松本 耕祐, 榊原 晶子, 木本 明, 長谷川 巧実, 鈴木 泰明, 南川 勉, 古土井 春吾, 古森 孝英

    (NPO)日本口腔科学会, 2016年07月, 日本口腔科学会雑誌, 65 (2), 176 - 177, 日本語

  • 下顎骨骨折の治療を行ったLennox-Gastaut症候群患児の1例

    中西 洋介, 松本 耕祐, 小守 紗也華, 長谷川 巧実, 明石 昌也, 柚鳥 宏和, 橘 進彰, 古森 孝英

    (一社)日本外傷歯学会, 2016年07月, 日本外傷歯学会総会・学術大会プログラム・抄録集, 16回, 41 - 41, 日本語

  • Masaya Akashi, Yasuyuki Shibuya, Satoru Takahashi, Kazunobu Hashikawa, Takumi Hasegawa, Yasumasa Kakei, Noriyuki Negi, Toshinori Sekitani, Takahide Komori

    Purpose: The purpose of this study was to analyze jaw movement during mastication in patients who underwent mandibular reconstruction following segmental mandibulectomy, including mouth opening and mastication time, based on four-dimensional computed tomography (4D CT) images. Material and methods: This study included six surgical patients, who underwent segmental mandibulectomy and simultaneous reconstruction with a free fibula osteocutaneous flap, and four controls. 4D CT was performed during mastication of a cookie to evaluate the movement of the jaw during natural function. The maximum mouth opening, mastication time, and movement of the mandibular angle during mastication were evaluated from the 4D CT images. Results: 4D CT images enabled visualization of jaw movement during mastication. When compared with the controls, the maximum mouth opening during mastication and excursion of the mandibular angle, especially on the diseased side, tended to decrease in surgical patients; however, this did not occur with mastication time. The numerical differences between the diseased and nondiseased side in surgical patients tended to be higher than the crosswise differences in controls. Conclusion: 4D CT images revealed differences in jaw function between patients who underwent mandibular reconstruction and controls. 4D CT could be used to evaluate postoperative outcomes following mandibular reconstruction. (C) 2016 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

    CHURCHILL LIVINGSTONE, 2016年05月, JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY, 44 (5), 637 - 641, 英語

    [査読有り]

    研究論文(学術雑誌)

  • 口腔扁平上皮癌における術後補助療法の指標となる頸部リンパ節転移の被膜外浸潤の進展度分類の検討

    山田 慎一, 大鶴 光信, 柳本 惣市, 長谷川 巧実, 鎌田 孝広, 相澤 仁志, 山川 延宏, 高後 友之, 伊藤 章, 大倉 正也

    (一社)日本頭頸部癌学会, 2016年05月, 頭頸部癌, 42 (2), 169 - 169, 日本語

  • 下歯肉がんのT分類(多施設共同後ろ向き研究JOOG RA-1401)

    大倉 正也, 伊藤 章, 太田 嘉英, 大鶴 光信, 梅田 正博, 柳本 惣市, 桐田 忠昭, 山川 延宏, 長谷川 巧実, 古森 孝英, 栗田 浩, 鎌田 孝広, 山下 徹郎, 上田 倫弘

    (一社)日本頭頸部癌学会, 2016年05月, 頭頸部癌, 42 (2), 179 - 179, 日本語

  • 口腔癌病理学的再発高リスク例に対する術後補助療法の検討

    長谷川 巧実, 大鶴 光信, 柳本 惣市, 鳴瀬 智史, 南川 勉, 太田 嘉英, 梅田 正博, 古森 孝英

    (一社)日本頭頸部癌学会, 2016年05月, 頭頸部癌, 42 (2), 204 - 204, 日本語

  • 歯科インプラント埋入のためのデンタルCTを用いた移植腓骨の形態評価

    明石 昌也, 橋川 和信, 鰐渕 聡, 楠元 順哉, 長谷川 巧実, 南川 勉, 寺師 浩人, 古森 孝英

    (一社)日本頭頸部癌学会, 2016年05月, 頭頸部癌, 42 (2), 147 - 147, 日本語

  • 有本 智美, 長谷川 巧実, 岡本 奈々, 塩屋園 敦, 立石 千鶴, 明石 昌也, 鈴木 泰明, 古土井 春吾, 古森 孝英

    (NPO)日本顎変形症学会, 2016年05月, 日本顎変形症学会雑誌, 26 (2), 183 - 183, 日本語

  • Eiji Iwata, Takumi Hasegawa, Daisuke Takeda, Takeshi Ueha, Teruya Kawamoto, Toshihiro Akisue, Yoshitada Sakai, Takahide Komori

    Oral squamous cell carcinoma (OSCC) is the most common form of oral cancers. Recent studies have shown that the malignant transformation of various carcinomas, including OSCC, is associated with epithelial-mesenchymal transition (EMT), and that expression of the EMT factors are significantly associated with tumor invasion, tumor metastasis, and survival rates in OSCC patients. Hence, there is a possibility that EMT suppression may improve the prognosis of OSCC patients. Hypoxia inducible factor-1α (HIF-1α) is a crucial microenvironmental factor in tumor progression, which induces the expression of EMT factors. We previously reported that transcutaneous CO2 suppresses both human OSCC tumor growth and metastasis to the regional lymph nodes by improving hypoxia in treated tissue. According to this background, we hypothesized that increased EMT with HIF-1α expression may increase the progression and the metastatic potential of OSCC, and that decreased hypoxia by transcutaneous CO2 could suppress EMT. In the present study, in vitro studies showed that hypoxic conditions increased the expression of HIF-1α and EMT factors in OSCC cells. In addition, in vivo studies revealed that transcutaneous CO2 increased E-cadherin expression with the decreased expression of HIF-1α, Snail, Slug, N-cadherin, and Vimentin in tumor treatment. These results suggest that transcutaneous CO2 could suppress EMT by improving hypoxia, resulting in the reduction of metastatic potential of OSCC. The findings indicate that transcutaneous CO2 may be able to improve the prognosis of OSCC patients through the suppression of EMT.

    2016年04月, International journal of oncology, 48 (4), 1493 - 8, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • 当科における心臓血管外科周術期の口腔機能管理に関する実態と今後の課題

    難波 渚, 西井 美佳, 田村 恵利, 富田 和, 長谷川 巧実, 明石 昌也, 古土井 春吾, 古森 孝英

    (一社)日本口腔ケア学会, 2016年03月, 日本口腔ケア学会雑誌, 10 (1), 199 - 199, 日本語

  • 当院における周術期口腔機能管理に関する実態調査と今後の課題

    田村 惠利, 西井 美佳, 冨田 和, 難波 渚, 長谷川 巧実, 明石 昌也, 古土井 春吾, 古森 孝英

    (一社)日本口腔ケア学会, 2016年03月, 日本口腔ケア学会雑誌, 10 (1), 225 - 225, 日本語

  • S. Yamada, S. Yanamoto, S. Otani, T. Hasegawa, M. Miyakoshi, T. Minamikawa, N. Ohga, T. Kamata, T. Komori, Y. Kitagawa, H. Kurita, M. Umeda

    Only a few reports on the level of progression of extracapsular spread (ECS) have been published. The aim of this study was to evaluate the efficacy of the level of progression of ECS in identifying those patients with oral squamous cell carcinoma (OSCC) at a high risk of recurrence who would benefit most from the intensification of adjuvant therapy. The level of progression of ECS for cervical lymph node metastasis in OSCC was divided into three types (A-C), and their relationships with patient prognosis were examined. ECS was observed in 87 of 441 patients with OSCC. The recurrence rate in patients with type C, which was defined as macroscopic tumour invasion into perinodal fat or muscle tissue, was high (69.8%), with 13 cases of death due to distant metastasis. The 3-year disease specific survival rate for patients with type C was 49.0% and these patients also had a significantly poorer prognosis (P < 0.01). The results of the multivariate analysis suggested that the prognosis of ECS in OSCC patients was associated with the level of progression of ECS, especially type C (P < 0.01). Overall, the results of this study suggest that the level of progression of ECS is a useful prognostic factor in OSCC patients.

    CHURCHILL LIVINGSTONE, 2016年02月, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 45 (2), 141 - 146, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Yasumasa Kakei, Masaya Akashi, Takumi Hasegawa, Tsutomu Minamikawa, Satoshi Usami, Takahide Komori

    Purpose: Patients with oral cancer who undergo resection with simultaneous reconstruction are presumed to be at high risk for developing venous thromboembolism (VTE) according to current criteria. The primary purpose of this retrospective study was to report the incidence of VTE after oral cancer surgery requiring primary reconstruction and to identify the potential risk factors for VTE in this population. Materials and Methods: This retrospective study evaluated 133 consecutive patients who had undergone oral cancer resection with simultaneous reconstruction from April 2007 through December 2014. Bilateral lower-extremity venous duplex ultrasonography (VDUS) was routinely performed 2 days after surgery. Pulmonary embolism was confirmed with computed tomography. The Caprini risk score (CRS) was obtained for each patient. Patients with and without VTE were compared using the chi(2) test and Student t test with some variables. Univariate predictors associated with VTE were entered into a multivariate logistic regression analysis. A P value less than .05 was regarded as indicating statistical significance. Results: The incidence of VTE after oral oncologic surgery with simultaneous reconstruction was 26.3% (35 of 133 patients): deep vein thrombosis (DVT) and pulmonary embolism occurred in 2.3% (3 of 133) and DVT alone was found in 24.0% (32 of 133). Multivariate logistic regression analysis showed that only a high CRS was statistically relevant to VTE occurrence. Conclusions: Because a high incidence of VTE was found after major oral and maxillofacial surgery, lower-extremity VDUS should be undertaken in patients who undergo oral cancer surgery with simultaneous reconstruction, especially those with a high CRS. (C) 2016 American Association of Oral and Maxillofacial Surgeons

    W B SAUNDERS CO-ELSEVIER INC, 2016年01月, JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 74 (1), 212 - 217, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Meaning and limitation of cortical bone width measurement with DentaScan in medication-related osteonecrosis of the jaws

    Eiji Iwata, Masaya Akashi, Megumi Kishimoto, Junya Kusumoto, Takumi Hasegawa, Shungo Furudoi, Takahide Komori

    Mandibular cortical bone measurement with x-ray imaging is known to be a potentially useful tool in the detection of dimensional changes caused by bisphosphonate. The primary purpose of this study was to assess the meaning and limitation of cortical bone measurement with computed tomography (CT) in patients with medication-related osteonecrosis of the jaw (MRONJ). The investigators obtained DentaScan images of the mandible from 15 patients with MRONJ, 15 patients with a history of antiresorptive agent administration without symptoms of MRONJ (non-MRONJ), and 15 control subjects. The cortical bone width measured on DentaScan images was compared between the three groups (ANOVA and Tukey’s test). Interobserver reliability between two observers was also assessed. The values of interclass correlation coefficient were 0.48 in the MRONJ group, 0.29 in the Non-MRONJ group, and 0.34 in control group. The cortical bone widths calculated both by observer 1 and observer 2 were thicker in patients with MRONJ than in the non-MRONJ group and controls. There were significant differences in cortical bone width among the MRONJ, non-MRONJ, and control groups in observer 1 (P < 0.001) and observer 2 (P < 0.001), specifically comparing the MRONJ group with the non-MRONJ group and the control group. Cortical bone width measurement is useful for the distinction between medication-related osteonecrosis of the jaw and normal bone, in spite of the low interobserver reliability.

    Kobe University School of Medicine, 2016年, Kobe Journal of Medical Sciences, 62 (5), E114 - E119, 英語

    [査読有り]

    研究論文(学術雑誌)

  • 食道がん術後肺炎予防に対する周術期口腔機能管理の有効性 多施設共同後ろ向き研究による検証.

    五月女さき子, 船原まどか, 於保孝彦, 山田慎一, 栗田 浩, 山内千佳, 渋谷恭之, 兒島由, 佳, 長谷川巧実, 古森孝英, 梅田正博

    2016年, 日本口腔科学会誌, 65, 324-329

    [査読有り]

  • Akira Kimoto, Yasuyuki Shibuya, Masaki Kobayashi, Masaya Akashi, Takumi Hasegawa, Hiroaki Suzuki, Takahide Komori

    Background: Prostheses and dental implants are often used to aid oral rehabilitation after surgery ( with/without radiotherapy) for oral cancer. However, some studies have reported that the insertion of dental implants into irradiated bone results in a higher frequency of implant failure than the insertion of such implants in nonirradiated bone. Materials and Methods: This report describes the cases of 4 patients with oral cancer who underwent surgery and radiotherapy ( total dose: 50-86 Gy) and then had dental implants inserted within the irradiated area. In each case, an ilium bone graft or a latissimus dorsi myocutaneous flap containing scapular bone was transferred to the dental implant site before the insertion of the implants. Results: Twenty-three implants were inserted. After loading, 2 implants were lost, and 21 remained stable. Conclusion: In patients who have undergone radiotherapy for oral cancer, transferring bone grafts harvested from nonirradiated tissue to the irradiated site before implant insertion might help to improve dental implant survival rates.

    LIPPINCOTT WILLIAMS & WILKINS, 2016年, IMPLANT DENTISTRY, 25 (5), 715 - 719, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Akashi M, Shibuya Y, Takahashi Y, Kusumoto J, Sakakibara A, Hasegawa T, Minamikawa T, Hashikawa K, Komori T

    2016年, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology., 28, 111 - 117, 日本語

    [査読有り]

    研究論文(学術雑誌)

  • ロケーター・磁性バーアタッチメントによるインプラントオーバーデンチャー関連合併症

    有本智美, 長谷川巧実, 斉藤泉, 岩田英治, 武田大介, 明石昌也, 鈴木泰明, 古土井春吾, 古森孝英

    2015年11月, Japanese Journal of Maxillo Facial Implants, 14 (3号), 261, 日本語

    研究論文(その他学術会議資料等)

  • Masaya Akashi, Yasuyuki Shibuya, Satoshi Wanifuchi, Junya Kusumoto, Akiko Sakakibara, Akira Kimoto, Takumi Hasegawa, Hiroaki Suzuki, Kazunobu Hashikawa, Takahide Komori

    Background:Dental rehabilitation with osseointegrated implants in reconstructed mandibles remains one of the most challenging procedures for oral and maxillofacial surgeons. Satisfactory outcome requires appropriate assessment of graft morphology. There are few analyses of the morphology of fibulae in reconstructed mandibles, although cadaver studies on fibular shape have been performed.Materials and Methods:In this study, we used postoperative computed tomography to retrospectively evaluate the shape, height, and orientation of fibulae transferred after mandibulectomy in 19 patients.Results:The average height of transferred fibulae was 14.3 mm (range, 10.8-20.5 mm). The cross-sectional morphology of transferred fibulae could be classified into 2 types: apex and nonapex. The former type included knife-edged and triangular shapes; the latter included square and circular shapes.Conclusion:When implant insertion is planned in a reconstructed mandible, the orientation of the apex of transferred fibula should be evaluated preoperatively to allow for adjustments in implant procedure because the ridge at the apex of the fibula is narrow.

    LIPPINCOTT WILLIAMS & WILKINS, 2015年10月, IMPLANT DENTISTRY, 24 (5), 541 - 546, 英語

    [査読有り]

    研究論文(学術雑誌)

  • 放射線治療後の甲状腺機能低下による低ナトリウム血症の1例

    村田陽太郎, 長谷川巧実, 八橋明子, 明石昌也, 南川勉, 古土井春吾, 古森孝英

    2015年09月, 日本口腔科学会雑誌, 64 (3号), 301, 日本語

    研究論文(その他学術会議資料等)

  • Takumi Hasegawa, Izumi Saito, Daisuke Takeda, Eiji Iwata, Natsuki Yonezawa, Yasumasa Kakei, Akiko Sakakibara, Masaya Akashi, Tsutomu Minamikawa, Takahide Komori

    Objective: The purpose of this study was to retrospectively investigate the multivariate relationships among the various risk factors for postoperative delirium in patients undergoing oral cancer surgery. Material and methods: The medical records of all patients with oral cancer who underwent curative head and neck surgery between April 2011 and March 2013 at our institution were retrospectively reviewed. There was a total of 188 patients, including 110 males and 78 females. Results: We found that older age, extensive surgical procedure, longer operation, excessive hemorrhage, blood transfusion, longer postoperative management in the intensive care unit, longer postoperative hospital stay, lower albumin level in the preoperative blood test, and lower total protein, albumi, n and hemoglobin levels and a higher C-reactive protein (CRP) level in the postoperative blood tests were significant variables in the univariate analysis (p < 0.05). We also determined that an older age (odds ratio [OR] = 6.83), intraoperative lower hemoglobin levels (OR = 6.82), and excessive hemorrhage (OR = 3.62) during surgery were significant variables in the multivariate analysis. Conclusion: Clinicians should pay special attention to preventing delirium during the postoperative management of older patients with these risk factors. Furthermore, increasing the hemoglobin levels during surgery may be able to prevent postoperative delirium. (C) 2015 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

    CHURCHILL LIVINGSTONE, 2015年09月, JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY, 43 (7), 1094 - 1098, 英語

    [査読有り]

    研究論文(学術雑誌)

  • 頭頸・口腔 口腔がん治療の個別化を目指して 下歯肉・下顎癌のUICC分類と下顎管分類に関する多施設共同後ろ向き研究JOOG RA-1401

    大倉 正也, 相川 友直, 太田 嘉英, 大鶴 光信, 梅田 正博, 柳本 惣市, 桐田 忠昭, 山川 延宏, 栗田 浩, 鎌田 孝広, 長谷川 巧実, 古森 孝英, 山下 徹郎, 上田 倫弘

    (一社)日本癌治療学会, 2015年09月, 日本癌治療学会誌, 50 (3), 2196 - 2196, 日本語

  • M. Akashi, K. Hashikawa, Y. Kakei, A. Sakakibara, T. Hasegawa, T. Minamikawa, T. Komori

    The purpose of this study was to sequentially evaluate bone union of fibular grafts in mandibular reconstruction. Patients who underwent routine follow-up computed tomography (CT) and panoramic X-ray imaging during a period of >= 2 years were enrolled. On panoramic X-ray images, bone union was scored as 0 (absent callus formation) or 1 (complete callus formation). On CT images, a scale of 0 to 2 was used (0, absent callus formation; 1, complete callus formation only on the labial side; 2, complete callus formation on both the labial and lingual side). A total of 56 bone junctions were evaluated in 20 patients. Five of 56 junctions (9%) in four of 20 patients (20%) showed radiological non-union (panoramic X-ray score = 0, CT score = 0 or 1) at 2 years after surgery. All bone junctions with radiological nonunion were located at the mandibular angle. No categorical values, including diabetes mellitus and radiation therapy, were significantly associated with radiological non-union. In conclusion, assessing at least two sides (i.e. labial and lingual sides) on CT images is adequate to evaluate bone union in transferred fibula flaps. Careful fixation at the mandibular angle may improve the rate of bone union.

    CHURCHILL LIVINGSTONE, 2015年08月, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 44 (8), 942 - 947, 英語

    [査読有り]

    研究論文(学術雑誌)

  • S. Arimoto, T. Hasegawa, N. Okamoto, A. Shioyasono, C. Tateishi, M. Akashi, H. Suzuki, S. Furudoi, T. Komori

    The purpose of this study was to examine the efficacy of ultrasonography (US) and unenhancedmagnetic resonance imaging(MRI) to determine the location of the internal maxillary artery (IMA) beforeorthognathic surgery. The study subjects were 19 patients (seven males and twelve females) with mandibular prognathismseen at the authors' institution between March 2012 and April 2013.The distance from the skin to the IMA (S-IMA)and the distance from the mandibular notch to the IMA (MN-IMA) were measured. Using the US and coronal MRI images, S-IMA(cl)and MN-IMA(cl) in the closed position and S-IMA(op) and MN-IMA(op) in the open position were measured at a total of four points in each cross-section. There were significant correlations between the distances measured on coronal MRI and US for all groups (P < 0.05). A total of 35 (92%) IMAs were classified as clear and three (8%) as unclear based on the US findings. Regarding the location of the IMA, 37 of the 38 sides studied (97%) were of the lateral type, while only one (3%) was of the medial type. The results of this study indicate that US can be used effectively to determine the location of the IMA.

    CHURCHILL LIVINGSTONE, 2015年08月, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 44 (8), 977 - 983, 英語

    [査読有り]

    研究論文(学術雑誌)

  • W. Huang, T. Hasegawa, Y. Imai, D. Takeda, M. Akashi, T. Komori

    We previously demonstrated that human mandibular fracture haematoma-derived cells (MHCs) play an important role in mandibular fracture healing and that low-intensity pulsed ultrasound (LIPUS) accelerates this effect by stimulating various osteogenic cytokines. In the present study, we investigated how LIPUS affects the expression of bone morphogenetic proteins (BMPs), which are also known to have the ability to induce bone formation. MHCs were isolated from human mandibular fracture haematomas and the cells were divided into two groups: a LIPUS (+) group and a LIPUS (-) group, both of which were cultured in osteogenic medium. LIPUS was applied to the LIPUS (+) group 20 min a day for 4, 8, 14, and 20 days (1.5 MHz, 30 mW/cm(2)). Real-time PCR and immunofluorescence studies were carried out to determine the expression of BMP-2, 4, and 7. Compared to the LIPUS (+) group, gene expression levels were significantly increased in the LIPUS (+) group for BMP-2 on day 20 (67.38 +/- 26.59 vs. 11.52 +/- 3.42, P<0.001), for BMP-4 on days 14 (45.12 +/- 11.06 vs. 9.20 +/- 2.88, P=0.045) and 20 (40.96 +/- 24.81 vs. 3.22 +/- 1.53, P=0.035), and for BMP-7 on day 8 (48.11 +/- 35.36 vs. 7.03 +/- 3.96, P=0.034). These findings suggest that BMP-2, 4, and 7 may be mediated by LIPUS therapy during the bone repair process.

    CHURCHILL LIVINGSTONE, 2015年07月, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 44 (7), 929 - 935, 英語

    [査読有り]

    研究論文(学術雑誌)

  • 口腔癌患者への緩和ケアチームの介入に関する臨床的検討

    米澤奈津季, 南川勉, 高橋佑輔, 榊原晶子, 長谷川巧実, 重田崇至, 渋谷恭之, 古森孝英

    2015年06月, 日本口腔腫瘍学会誌, 27 (2号), 13 - 20, 日本語

    [査読有り]

    研究論文(学術雑誌)

  • Takumi Hasegawa, Makiko Tanakura, Daisuke Takeda, Akiko Sakakibara, Masaya Akashi, Tsutomu Minamikawa, Takahide Komori

    Objective The purpose of this study was to retrospectively evaluate the incidence of distant metastasis (DM) after curative surgical treatment and assess the multivariate relationships among various risk factors for DM in patients with oral squamous cell carcinoma (OSCC). Study Design Case series with chart review. Setting Tertiary referral center. Subjects and Methods The medical records of all patients with OSCC without DM who underwent curative surgery with or without postoperative adjuvant chemoradiation between January 2001 and February 2014 at our institution were retrospectively reviewed. There were a total of 451 patients, including 271 men and 180 women, with a mean age of 65.9 13.5 years. Results Of these patients, 30 (6.7%) developed DM. During the follow-up period, the 5-year overall survival rate was 76.2%. Sites of DM comprised the lungs (80.0%), skin (13.3%), liver (10.0%), bone (6.7%), and brain (3.3%). We found the T classification and N classification as well as the histologic grade to be significant risk factors associated with the development of DM in the univariate analysis only (P = .003), whereas locoregional failure (odds ratio [OR], 4.03), multiple lymph node metastases (more than 4 positive nodes; OR, 3.32) and positive extracapsular spread (OR, 3.06) were identified to be significant risk factors associated with the development of DM in the multivariate analysis. Conclusion We demonstrated multivariate relationships among various risk factors for DM in OSCC patients. Clinicians should consider these risk factors and pay special attention to detecting DM early during the postoperative management of OSCC patients with these risk factors.

    SAGE PUBLICATIONS LTD, 2015年06月, OTOLARYNGOLOGY-HEAD AND NECK SURGERY, 152 (6), 1053 - 1060, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Facial emphysema after sinus lift

    SakakibaraA, SuzukiH, YamashitaA, HasegawaT, MinamikawaT, FurudoiS, KomoriT

    2015年06月, J Surg Case Rep, 6, 1 - 4, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Akiko Sakakibara, Tsutomu Minamikawa, Kazunobu Hashikawa, Shunsuke Sakakibara, Takumi Hasegawa, Masaya Akashi, Shungo Furudoi, Takahide Komori

    Purpose: Tissue that is resected for the treatment of oral tumors often includes salivary gland ducts. At their institution, the authors conserve and transfer as much of the salivary duct as possible during these procedures to avoid obstructive complications. Differentiating these obstructive complications from a metastatic node can be challenging and can confound subsequent oncologic management. This study compared and examined the effectiveness of salivary duct repositioning in decreasing the incidence of obstructive complications. Materials and Methods: Cases of oromandibular disease treated with salivary duct resection at Kobe University Graduate School of Medicine from 2008 to 2013 were retrospectively analyzed. Thirty-two cases (25 patients) of Wharton duct resection and 31 cases (31 patients) of Stensen duct resection were included. The incidence of complications after salivary duct repositioning, duct ligation, and retention of the sublingual gland around the Wharton duct was compared. Results: Wharton ducts were repositioned in 30 cases and ligated in 2 cases. Complications, including oral swelling at the Wharton duct, were observed in 5 cases of repositioning and 2 cases of ligation. Stensen ducts were repositioned in 9 cases and ligated in 22 cases. The only complication reported was a single case of salivary fistula after ligation. Conclusions: Salivary duct repositioning is performed to prevent blockage of physiologic salivary discharge. Complications were more frequently associated with Wharton ducts than with Stensen ducts because of the unique physiologic and anatomic characteristics of the Wharton duct. Repositioning of the salivary duct is a suitable method for preventing complications associated with the Wharton duct. (c) 2015 American Association of Oral and Maxillofacial Surgeons

    W B SAUNDERS CO-ELSEVIER INC, 2015年05月, JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 73 (5), 1003 - 1007, 英語

    [査読有り]

    研究論文(学術雑誌)

  • 抗RANKLモノクローナル抗体(デノスマブ)投与患者に発症した顎骨壊死の1例

    岩田英治, 明石昌也, 長谷川巧実, 古土井春吾, 古森孝英

    (一社)日本口腔感染症学会, 2015年05月, 日本口腔感染症学会雑誌, 22 (1号), 41 - 42, 日本語

    研究論文(その他学術会議資料等)

  • 外科的矯正手術前後における顎関節症状および顎関節MRI画像の変化

    定兼啓倫, 長谷川巧実, 有本智美, 岡本奈々, 塩屋園敦, 立石千鶴, 明石昌也, 鈴木泰明, 古土井春吾, 古森孝英

    2015年05月, 日本顎変形症学会雑誌, 25 (2号), 117, 日本語

    研究論文(その他学術会議資料等)

  • 下顎枝垂直骨切り術後の近位骨片と下顎頭変化の評価

    有本智美, 長谷川巧実, 定兼啓倫, 岡本奈々, 塩屋園敦, 立石千鶴, 明石昌也, 鈴木泰明, 古土井春吾, 古森孝英

    2015年05月, 日本顎変形症学会雑誌, 25 (2号), 134, 日本語

    研究論文(その他学術会議資料等)

  • Masaya Akashi, Shungo Furudoi, Kazunobu Hashikawa, Akiko Sakakibara, Takumi Hasegawa, Takashi Shigeta, Tsutomu Minamikawa, Takahide Komori

    Background: C-reactive protein (CRP) screening has been reported to be reliable for detection of infectious complications. Postoperative abnormal response of CRP can predict wound infection in colorectal surgery. This study aimed to determine the efficacy of CRP monitoring to detect infectious complications in oral oncologic surgery. Methods: One hundred patients who underwent oral cancer resection with primary reconstruction were enrolled. Postoperative kinetics of CRP were classified into a normal or abnormal response. Results: A normal CRP response after surgery was observed in 61 patients and an abnormal response was observed in 39. There were postoperative infectious complications in 21 patients, with surgical site infections in 13 patients (early onset in six and late onset in seven). Non-wound infections were found in nine patients. Sensitivity, specificity, the positive predictive value, and the negative predictive value for abnormal CRP response as a predictor for early infectious complications were 100%, 70.1%, 35.9%, and 100%, respectively. Conclusion: Postoperative serial CRP screening is a useful test as an indicator of infectious complications in oral oncologic surgery. Normal CRP responses can rule out almost all early infectious complications.

    BIOMED CENTRAL LTD, 2015年04月, JOURNAL OF OTOLARYNGOLOGY-HEAD & NECK SURGERY, 44, 13, 英語

    [査読有り]

    研究論文(学術雑誌)

  • T Hasegawa, C Tateishi, M Asai, Y Imai, N Okamoto, A Shioyasono, A Kimoto, M Akashi, H Suzuki, S Furudoi, T Komori

    We investigated changes in the sensitivity of cutaneous points and the oral mucosa after sagittal split ramus osteotomy (SSRO) and assessed the differences between SSRO and intraoral vertical ramus osteotomy (IVRO). The subjects included in this study were 46 patients with mandibular prognathism who underwent IVRO (88 rami) and 30 patients who underwent SSRO (59 rami). An objective evaluation of the neurosensory status of each patient was completed preoperatively and at 1, 4, 8, 12, and 24 weeks postoperatively. Other variables studied for each patient included sex, age, magnitude of mandibular setback, and amount of blood loss during surgery. We found that a neurosensory recovery occurred earlier in the oral mucosa than at cutaneous points. The number of oral mucosa points showing reduced neurosensory function and neurosensory disturbance after SSRO was significantly higher than after IVRO at 1, 4, and 8 weeks (P<0.05). The nerve recovery observed after SSRO was delayed for a longer period than that noted in our previous study of IVRO. In conclusion, we found changes in sensitivity at cutaneous points and the oral mucosa after SSRO and assessed the differences between SSRO and IVRO.

    2015年03月, International journal of oral and maxillofacial surgery, 44 (3), 349 - 55, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Y. Imai, T. Hasegawa, D. Takeda, M. Akashi, T. Komori

    It is known that bisphosphonates (BPs) suppress the activity of osteoclasts; however, it has not been reported whether BPs affect the potential of human mandibular fracture haematoma-derived cells (MHCs) for bone differentiation. In this study, we examined whether the degree of bone differentiation changes following the administration of BP in vitro. The effects of alendronate and risedronate (10(-8) to 10(-7) M (mol/l)) on cell proliferation were evaluated at 4 and 8 days, after which BP treatment was applied for 4, 8, 14, and 20 days prior to assessing the alkaline phosphatase (ALP) activity and performing the mineralization assay. Alendronate 10(-8) and 10(-7) M and risedronate 10(-7) M decreased the degree of cell proliferation on day 8 (P < 0.05). Using an ELISA, the ALP activity of the control, alendronate 10(-8) M, risedronate 10(-8) M, and risedronate 10(-7) M groups were 112.1 +/- 10.2%, 156.1 +/- 24.3%, 138.8 +/- 16.5%, and 133.3 +/- 10.3%, respectively, at 14 days after treatment (day 0 in each group was considered to be 100%). ALP activity was significantly higher in the alendronate 10(-8) M and risedronate 10(-8) and 10(-7) M groups than in the control group (P = 0.010, 0.014, and 0.009, respectively). It is possible that BPs increase the potential of MHCs for osteogenic differentiation depending on the concentration of the drug.

    CHURCHILL LIVINGSTONE, 2015年03月, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 44 (3), 412 - 416, 英語

    [査読有り]

    研究論文(学術雑誌)

  • 後方への進展なくルビエールリンパ節に転移を生じた口腔癌2例

    重田 崇至, 南川 勉, 明石 昌也, 長谷川 巧実, 榊原 晶子, 松井 太輝, 筧 康正, 高橋 佑輔, 渋谷 恭之, 梅田 正博, 古森 孝英

    外側咽頭後リンパ節は後咽頭隙内で椎前筋の外側、内頸動脈の内側に位置しており、鼻副鼻腔、軟口蓋、上・中咽頭からリンパ流を受け内頸静脈に輸出リンパ管を送るリンパ節で、その最上方のものはルビエールリンパ節と称される。ルビエールリンパ節へは咽頭癌からの転移がしばしばみられるが、口腔癌の転移はまれとされている。ルビエールリンパ節に転移するような口腔癌への適切な治療方法は確立されておらず、その予後は極めて不良とされている。今回後方への浸潤がないにもかかわらずルビエールリンパ節に転移を生じた口腔癌2例を経験したので報告する。2例中1例は傍咽頭隙郭清を施行し、7年経過した現在無病生存で経過良好である。後方への浸潤のない口腔癌のルビエールリンパ節への転移機序、傍咽頭隙郭清の有用性について検討を行った。(著者抄録)

    (一社)日本口腔腫瘍学会, 2015年03月, 日本口腔腫瘍学会誌, 27 (1), 1 - 6, 日本語

    [査読有り]

    研究論文(学術雑誌)

  • 急速に増大し巨舌を呈した多発性骨髄腫に伴うアミロイドーシスの1例

    藤田剛史, 井堂信二郎, 大槻有美, 江崎友美, 長谷川巧実, 古森孝英

    2015年01月, 日本口腔外科学会雑誌, 61 (1号), 25 - 30, 日本語

    [査読有り]

    研究論文(学術雑誌)

  • Spindle cell carcinoma of the oral cavity: The impact of chemotherapy on pulmonary metastatic tumor doubling time

    Takashi Shigeta, Tsutomu Minamikawa, Taiki Matsui, Yasumasa Kakei, Masaya Akashi, Takumi Hasegawa, Akiko Sakakibara, Yasuyuki Shibuya, Takahide Komori

    Spindle cell carcinoma (SpCC) an aggressive squamous cell carcinoma, variant, frequently metastasizes to regional lymph nodes and distant organs. Unfortunately, an effective treatment method for oral SpCC distant metastasis has not yet been established. Here we present 2 of oral SpCC cases that showed distant metastases after initial treatment, and 2 that showed distant metastases following during surgery. We calculated the tumor doubling time (TDT) and onset of the pulmonary metastatic and examined the TDT of the pulmonary metastatic tumor in patients with or without chemotherapy to determine the effect of anticancer drugs on oral SpCC. Tumor growth curves revealed that pulmonary metastasis likely grew to 1mm, 122 days before the initial examination, indicating that most oral SpCC patients should be treated for metastases. Three patients underwent chemotherapy for pulmonary metastatic tumor, complete response (CR) in one patient and no change (NC) in two. Thus, SpCC patients may have pulmonary micro-metastases even at the initial examination. We recommend wide resection for oral SpCC patients, followed by chemotherapy to prevent metastases.

    Kobe University School of Medicine, 2015年, Kobe Journal of Medical Sciences, 61 (3), E64 - E70, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Evaluation and comparison of CT values in bisphosphonate-related osteonecrosis of the jaw

    ImaiY, HasegawaT, TakedaD, KusumotoJ, AkashiM, LeeSY, FurudoiS, KomoriT

    2015年, J Oral Maxillofac Surg Med Pathol, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Clinical study of 19 cases resulting in dental implant removal

    Hiroaki Suzuki, Daiki Takahashi, Kenji Matsuo, Akira Kimoto, Kousuke Matsumoto, Takumi Hasegawa, Masaya Akashi, Takahide Komori

    Dental implant treatment is a highly anticipated therapy with widespread use. However, various accidental symptoms and complications have been reported, and we may reluctantly have to remove an implant body out of necessity. This study evaluated 19 cases (21 jaws) that resulted in removal after the enforcement of implant treatment in our hospital from January 2003 to August 2013 and clarified the details of the removals clinically for the purpose of improvement of future treatment results. Implants were removed at a higher frequency in elderly patients, particularly those 70 years of age or older. The removal rate regarding the tooth missing style was high in edentulous jaw cases in both the maxilla and mandible, and was low in defective cases of middle teeth. Regarding the duration and cause of removal, approximately half of the implants were removed due to defective primary stability within 6 months for periods greater than 6 months, all cases except 1 jaw were removed within 30 months and many cases were due to peri-implantitis. Preoperation evaluations, primary stability of the implant body at the time of the operation, long-term observation and maintenance, and patient education are crucial to reduce the frequency of removal.

    Kobe University School of Medicine, 2015年, Kobe Journal of Medical Sciences, 61 (4), E102 - E108, 英語

    [査読有り]

    研究論文(学術雑誌)

  • 当科における広範囲顎骨支持型インプラント補綴の臨床統計的検討

    今井 佑輔, 長谷川 巧実, 川畑 真哉, 武田 大介, 明石 昌也, 鈴木 泰明, 古森 孝英

    (公社)日本顎顔面インプラント学会, 2014年11月, Japanese Journal of Maxillo Facial Implants, 13 (3), 128 - 128, 日本語

  • 著明な上顎洞粘膜肥厚を有する患者に洞底挙上術後インプラント治療を行った1例

    榎本 由依, 鈴木 泰明, 木本 明, 長谷川 巧実, 明石 昌也, 浅井 知子, 竹内 純一郎, 古森 孝英

    (公社)日本顎顔面インプラント学会, 2014年11月, Japanese Journal of Maxillo Facial Implants, 13 (3), 144 - 144, 日本語

  • 当科におけるインプラント242例907本埋入に関する臨床的検討

    川畑 真哉, 長谷川 巧実, 今井 佑輔, 木本 明, 明石 昌也, 鈴木 泰明, 古森 孝英

    (公社)日本顎顔面インプラント学会, 2014年11月, Japanese Journal of Maxillo Facial Implants, 13 (3), 160 - 160, 日本語

  • 歯科インプラント埋入のためのCT画像を用いた移植腓骨の形態評価

    明石 昌也, 渋谷 恭之, 鰐渕 聡, 木本 明, 長谷川 巧実, 鈴木 泰明, 古森 孝英

    (公社)日本顎顔面インプラント学会, 2014年11月, Japanese Journal of Maxillo Facial Implants, 13 (3), 166 - 166, 日本語

  • ゾレドロネート反復投与による創傷治癒遅延の予防、治療法に関する研究

    古森 孝英, 長谷川 巧実, 今井 佑輔, 武田 大介, 浅井 雅敏

    2014年10月, Osteoporosis Japan, 22 (4), 706 - 709, 日本語

    研究論文(学術雑誌)

  • 舌背部に生じた顆粒細胞腫の1例

    岩田 英治, 長谷川 巧実, 南川 勉, 渋谷 恭之, 古森 孝英

    2014年10月, 日本口腔診断学会雑誌, 27 (3号), 253 - 256, 日本語

    [査読有り]

    研究論文(学術雑誌)

  • 口蓋に発生した嚢胞腺癌の1例

    高田 直樹, 渋谷 恭之, 長谷川 巧実, 木本 明, 鈴木 泰明, 古森 孝英

    2014年10月, 日本口腔外科学会雑誌, 60 (10号), 561 - 565, 日本語

    [査読有り]

    研究論文(学術雑誌)

  • T. Hasegawa, Y. Shibuya, T. Minamikawa, T. Komori

    There have been few reports of mouth closing disturbances in the final phase of occlusion caused by the posterior thickness of the retrodiscal tissue. Two such cases are described here. The first was a 70-year-old female suffering from a painless mouth closing disturbance on the right side of the temporomandibular joint (TMJ). She complained of a feeling like there was an air cushion. The second case was a 51-year-old male with a painless mouth closing disturbance on the left side of the TMJ. In both cases, magnetic resonance imaging (MRI) revealed enlargement of the posterior joint space on the affected side. The conditions of these two cases were improved by local injection of steroid preparations; however further additional treatments were required, including mandible traction in one case and dental prosthetics in the other. Consequently, we consider that the local injection of steroid preparations is useful as an initial treatment, while the use of local injection of steroid preparations alone is not sufficient for the treatment of posterior thickness of the retrodiscal tissue.

    CHURCHILL LIVINGSTONE, 2014年09月, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 43 (9), 1104 - 1107, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Yasumasa Kakei, Masaya Akashi, Takashi Shigeta, Takumi Hasegawa, Takahide Komori

    Background: To maintain normal function, the lymphatic endothelium is regulated by cell-cell junctions. There have been few studies of lymphatic endothelial cell junctions using standard cell biological methods. This study had two purposes: to characterize cell junctions in cultured lymphatic endothelial cells and to investigate the effects of the inflammatory cytokine TNF-alpha on altered cell-cell junctions. Methods and Results: Cultured human dermal lymphatic endothelial cells (HDLEC) were immunostained with the tight junction marker, ZO-1, and adherens junction markers, VE-cadherin and PECAM-1. In TNF-alpha-treated HDLEC, we evaluated changes in endothelial cell junctions by immunostaining and through the use of transendothelial electrical resistance (TER). Immunofluorescence staining of HDLEC revealed heterogeneity among the endothelial cell junctions, which could be classified into continuous and discontinuous junctions. In these cell junctions, ZO-1 and VE-cadherin were co-localized. Double immunofluorescence staining revealed the broad distribution of VE-cadherin at the cell periphery, where VE-cadherin and PECAM-1 were co-localized. TNF-alpha treatment decreased TER, caused a predominance in the appearance of discontinuous junctions with a reduction in the broad distribution of VE-cadherin at the cell periphery in HDLEC. Conclusions: The results indicate a heterogeneous distribution of cell junctions in HDLEC involving continuous and discontinuous junctions. Our data also suggest that TNF-alpha alters the normal distribution of cell junctions and affects the endothelial barrier of cultured lymphatic endothelial cells. The broad distribution of VE-cadherin at the cell periphery may reflect the lymphatic permeability.

    MARY ANN LIEBERT, INC, 2014年09月, LYMPHATIC RESEARCH AND BIOLOGY, 12 (3), 136 - 143, 英語

    [査読有り]

    研究論文(学術雑誌)

  • 口腔癌再建術後の頸部感染評価目的でのCTの有用性

    明石 昌也, 古土井 春吾, 南川 勉, 木本 明, 榊原 晶子, 長谷川 巧実, 後藤 育子, 渋谷 恭之, 古森 孝英

    (NPO)日本口腔科学会, 2014年09月, 日本口腔科学会雑誌, 63 (4), 381 - 381, 日本語

  • 周術期のD2受容体阻害薬投与が誘因となり急性ジストニアを発症したと考えられた顎変形症患者の1例

    柳田 匡彦, 古土井 春吾, 立石 千鶴, 長谷川 巧実, 渋谷 恭之, 古森 孝英

    2014年08月, 日本顎変形症学会雑誌, 24 (3号), 253 - 258, 日本語

    [査読有り]

    研究論文(学術雑誌)

  • Daisuke Takeda, Takumi Hasegawa, Takeshi Ueha, Yusuke Imai, Akiko Sakakibara, Masaya Minoda, Teruya Kawamoto, Tsutomu Minamikawa, Yasuyuki Shibuya, Toshihiro Akisue, Yoshitada Sakai, Masahiro Kurosaka, Takahide Komori

    Squamous cell carcinoma (SCC) is the main histological type of oral cancer. Its growth rate and incidence of metastasis to regional lymph nodes is influenced by various factors, including hypoxic conditions. We have previously reported that transcutaneous CO2 induces mitochondrial apoptosis and decreases lung metastasis by reoxygenating sarcoma cells. However, previous studies have not determined the sequential mechanism by which transcutaneous CO2 suppresses growth of epithelial tumors, including SCCs. Moreover, there is no report that transcutaneous CO2 suppresses lymphogenous metastasis using human cell lines xenografts. In this study, we examined the effects of transcutaneous CO2 on cancer apoptosis and lymphogenous metastasis using human SCC xenografts. Our results showed that transcutaneous CO2 affects expressions of PGC-1 alpha and TFAM and protein levels of cleavage products of caspase-3, caspase-9 and PARP, which relatives mitochondrial apoptosis. They also showed that transcutaneous CO2 significantly inhibits SCC tumor growth and affects expressions of HIF-1 alpha, VEGF, MMP-2 and MMP-9, which play essential roles in tumor angiogenesis, invasion and metastasis. In conclusion, transcutaneous CO2 suppressed tumor growth, increased mitochondrial apoptosis and decreased the number of lymph node metastasis in human SCC by decreasing intra-tumoral hypoxia and suppressing metastatic potential with no observable effect in vivo. Our findings indicate that transcutaneous CO2 could be a novel therapeutic tool for treating human SCC.

    PUBLIC LIBRARY SCIENCE, 2014年07月, PLOS ONE, 9 (7), e100530, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Sequential changes in oral dryness evaluated by a moisture-checking device in patients with oropharyngeal cancer during chemoradiotherapy: a pilot study

    Nishii M, Akashi M, Kakei Y, Hasegawa T, Minamikawa T, Furudoi S, Shibuya Y, Takahashi M, Otsuki N, Nibu K, Komori T

    2014年06月, Oral Health Dent Manag, 13 (2), 507 - 11, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Y. Shibuya, Y. Ohtsuki, C. Hirai, T. Hasegawa, M. Akashi, T. Shigeta, T. Minamikawa, T. Komori

    The purpose of this study was to determine the detailed background of cases of oral squamous cell carcinoma (OSCC) with microscopic extracapsular spread (ECS) in the cervical lymph nodes. The cases of 78 patients with primary OSCC, who attended hospital from October 2007 to July 2011 and underwent resection of the primary tumour with neck dissection, were reviewed. The subjects were classified into three categories: pN0, pN+/ECS-, and pN+/ECS+; the outcomes of pN+/ECS+ patients were compared in detail with those of the other categories. Thirty-one cases (39.7%) were pN0, 25 cases (32.1%) were pN+/ECS-, and 22 cases (28.2%) were pN+/ECS+. The 3-year overall survival rate was 82.1% in pN0, 74.1% in pN+/ECS-, and 39.8% in pN+/ECS+ (pN0 vs. pN+/ECS+, P = 0.0004; pN+/ECS- vs. pN+/ECS+, P = 0.0086). The 3-year disease-specific survival rate was 96.2% in pN0, 77.2% in pN+/ECS-, and 39.8% in pN+/ECS+ (pN0 vs. pN+/ECS+, P < 0.0001; pN+/ECS- vs. pN+/ECS+, P = 0.0038). Patients with poorly differentiated carcinoma, those with three or more ECS+ nodes, and those with ECS+ node(s) located at levels III, IV, and V, had the worst prognosis among pN+/ECS+ subjects.

    CHURCHILL LIVINGSTONE, 2014年04月, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 43 (4), 387 - 392, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Y. Imai, T. Hasegawa, D. Takeda, M. Akashi, S. Y. Lee, T. Niikura, Y. Shibuya, M. Kurosaka, T. Komori

    Low intensity pulsed ultrasound (LIPUS) stimulation is a clinically established treatment method used to accelerate long bone fracture healing; however, this method is currently not applied to mandibular fractures. In this study, we investigated the effects of LIPUS on human mandibular fracture haematoma-derived cells (MHCs) in order to explore the possibility of applying LIPUS treatment to mandibular fractures. MHCs were isolated from five patients. The cells were divided into two groups: (1) LIPUS (+) group: MHCs cultured in osteogenic medium with LIPUS treatment; and (2) LIPUS () group: MHCs cultured in osteogenic medium without LIPUS treatment. The osteogenic differentiation potential and proliferation of the MHCs were compared between the two groups. The waveform used was equal to the wave conditions of a clinical fracture healing system. The gene expression levels of ALP, OC, Runx2, OSX, OPN, and PTH-R1 and mineralization were increased in the LIPUS (+) group compared to the LIPUS () group. There were no significant differences in cell proliferation between the two groups. These findings demonstrate the significant effects of LIPUS on the osteogenic differentiation of MHCs. This study provides significant evidence for the potential usefulness of the clinical application of LIPUS to accelerate mandibular fracture healing.

    CHURCHILL LIVINGSTONE, 2014年03月, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 43 (3), 367 - 372, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Retrospective study of ameloblastoma: the possibility of conservative treatment.

    Takumi Hasegawa, Yusuke Imai, Daisuke Takeda, Daisuke Yasuoka, Shinshou Ri, Takashi Shigeta, Tsutomu Minamikawa, Yasuyuki Shibuya, Takahide Komori

    At our institutions, most cases of the solid or multicystic type were treated as conservatively as possible in order to avoid disadvantages of radical treatment. The aim of present study was to retrospectively analyze the ameloblastoma cases diagnosed at our two institutions, to classify them according to the criteria of the 2005 WHO classification, and to evaluate the possibility of using a conservative approach for the surgical treatment of ameloblastoma. Maxillary cases, unicystic cases, peripheral cases and resection-treated cases were excluded from this study. In 23 tumors of mandibular solid or multicystic ameloblastoma, a patient's age, gender, location, clinical signs, duration, radiographic appearance, preoperative diagnosis, ameloblastoma subtypes, treatment, and recurrence were investigated. The recurrence rate (48.7%) in this study was lower than the reported recurrence rate after conservative treatment for solid or multicystic ameloblastoma and was higher than the reported recurrence rate of ameloblastoma, inclusive of other types. However, all patients who were diagnosed with recurrences have maintained their quality of life and were satisfied for at least several years after the conservative treatment. In conclusion, we demonstrated one possibility that a conservative approach might be employed in the surgical treatment of ameloblastoma (even of the solid or multicystic type).

    2013年11月09日, The Kobe journal of medical sciences, 59 (4), E112-21 - 21, 英語, 国内誌

    [査読有り]

    研究論文(大学,研究機関等紀要)

  • 当科におけるインプラントの撤去に至った20例の臨床的検討

    高端 大希, 鈴木 泰明, 長谷川 巧実, 石田 優, 竹内 純一郎, 浅井 知子, 渋谷 恭之, 古森 孝英

    2013年11月, Japanese Journal of Maxillo Facial Implants, 12 (3号), 151, 日本語

    研究論文(その他学術会議資料等)

  • 下顎のスプリットクレスト法において遊離骨片が生じた6例の臨床的検討

    八橋 明子, 石田 優, 仲村 百合香, 小林 正樹, 長谷川 巧実, 鈴木 泰明, 渋谷 恭之, 古森 孝英

    2013年11月, Japanese Journal of Maxillo Facial Implants, 12 (3号), 115, 日本語

    研究論文(その他学術会議資料等)

  • CT画像における下顎舌側にみられる骨孔の観察

    浅井 知子, 渋谷 恭之, 仲村 百合香, 長谷川 巧実, 鈴木 泰明, 古森 孝英

    2013年11月, Japanese Journal of Maxillo Facial Implants, 12 (3号), 141, 日本語

    研究論文(その他学術会議資料等)

  • T. Hasegawa, C. Tateishi, M. Asano, N. Takata, M. Akashi, T. Shigeta, S. Furudoi, Y. Shibuya, T. Komori

    In this study we investigated the changes in the sensitivity of cutaneous points and the oral mucosa that occur after intraoral vertical ramus osteotomy (IVRO). Additionally, postoperative changes in the sensitivity and the relationships between neurosensory disturbance and factors associated with IVRO operations were evaluated. An objective evaluation of the neurosensory status of cutaneous points and the oral mucosa of each patient was completed preoperatively and at 1, 2, 4, 8, 12, and 24 weeks postoperatively. The other variables studied for each patient included sex, age, magnitude of mandibular setback, and the amount of haemorrhage that occurred during surgery. In addition, the relationships between neurosensory disturbance and factors connected with IVRO operations were evaluated. We found that at cutaneous points, contributing factors such as sex, age, the magnitude of mandibular setback, and haemorrhage were associated with an increased risk of neurosensory disturbance after IVRO. However, these factors were not associated with that in the oral mucosa. In conclusion, we demonstrated the changes that occur in the sensitivity of cutaneous points and the oral mucosa after IVRO, the postoperative changes in sensitivity, and the relationships between neurosensory disturbance and factors connected with IVRO operations.

    CHURCHILL LIVINGSTONE, 2013年11月, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 42 (11), 1454 - 1461, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Satomi Arimoto, Takumi Hasegawa, Kotaro Kaneko, Chizu Tateishi, Shungo Furudoi, Yasuyuki Shibuya, Takahide Komori

    Purpose: The purpose of this study was to observe long-term osseous healing of the cleavage space between bone fragments after intraoral vertical ramus osteotomy using computed tomographic (CT) values. Patients and Methods: CT examinations were performed to observe long-term osseous healing immediately after intraoral vertical ramus osteotomy and at 6 months, 1 year, and 2 years postoperatively. Bone fragments were observed on the interior and lateral sides. CT values between bone fragments were used to measure the range of each point within a 1.7- x 1.7-mm square, and the mean of the measurements was calculated. Results: CT values between bone fragments increased significantly over time at 1 month, 6 months, 1 year, and 2 years after surgery. Conclusions: Osseous healing in the cleavage between bone fragments after intraoral vertical ramus osteotomy was successful according to CT values. (C) 2013 American Association of Oral and Maxillofacial Surgeons

    W B SAUNDERS CO-ELSEVIER INC, 2013年09月, JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 71 (9), 1602, 英語

    [査読有り]

    研究論文(学術雑誌)

  • T. Hasegawa, S. Ri, T. Shigeta, M. Akashi, Y. Imai, Y. Kakei, Y. Shibuya, T. Komori

    In this study we investigated the relationships among the risk factors for inferior alveolar nerve injury (IANI), and the difference between preoperative imaging findings on panoramic radiographs and computed tomography (CT), by univariate and multivariate analyses. We determined the following to be significant variables by multivariate analysis: panoramic radiographic signs, such as the loss of the white line of the inferior alveolar canal or the diversion of the canal; excessive haemorrhage during extraction; and a close relationship of the roots to the IAN (type 1 cases) on CT examination. CT findings of type 1 were associated with a significantly higher risk (odds ratio 43.77) of IANI. In addition, many panoramic findings were not consistent with CT findings (275 of 440 teeth; 62.5%). These results suggest that CT findings may be able to predict the development of IANI more accurately than panoramic findings. Panoramic radiography alone did not provide sufficiently reliable images required for predicting IANI. Therefore, when the panoramic image is suggestive of a close relationship between the impacted tooth and the IAN, CT should be recommended as a means of conducting further investigations.

    CHURCHILL LIVINGSTONE, 2013年07月, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 42 (7), 843 - 851, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Y. Shibuya, S. Ishida, T. Hasegawa, M. Kobayashi, K. Nibu, T. Komori

    The aim of this study was to clarify the usefulness of colour-changing gum in evaluating masticatory performance after mandibulectomy. Thirty-nine patients who underwent mandibulectomy between 1982 and 2010 at Kobe University Hospital were recruited in this study. There were 21 male and 18 female subjects with a mean age of 64·7 years (range: 12-89 years) at the time of surgery. The participants included six patients who underwent marginal mandibulectomy, 21 patients who underwent segmental mandibulectomy and 12 patients who underwent hemimandibulectomy. The masticatory function was evaluated using colour-changing chewing gum, gummy jelly and a modified Sato's questionnaire. In all cases, the data were obtained more than 3 months after completing the patient's final prosthesis. The colour-changing gum scores correlated with both the gummy jelly scores (r = 0·634, P <  0·001) and the total scores of the modified Sato's questionnaire (r = 0·537, P <  0·001). In conclusion, colour-changing gum is a useful item for evaluating masticatory performance after mandibulectomy. © 2013 John Wiley & Sons Ltd.

    2013年07月, Journal of Oral Rehabilitation, 40 (7), 484 - 490, 英語

    [査読有り]

    研究論文(学術雑誌)

  • 外科的矯正治療により咬合改善を得た上下顎の歯数不調和を伴う下顎骨骨折変形治癒症例

    浅井 雅敏, 立石 千鶴, 山本 奈那, 長谷川 巧実, 筧 康正, 竹内 純一郎, 古土井 春吾, 澁谷 恭之, 古森 孝英

    (NPO)日本顎変形症学会, 2013年05月, 日本顎変形症学会雑誌, 23 (2), 174 - 174, 日本語

    研究論文(その他学術会議資料等)

  • 下顎枝垂直骨切り術における骨性治癒形態の経時的観察

    金子 児太郎, 立石 千鶴, 今井 佑輔, 長谷川 巧実, 福岡 裕樹, 古土井 春吾, 渋谷 恭之, 古森 孝英

    2013年05月, 日本顎変形症学会雑誌, 23 (2号), 93, 日本語

    研究論文(その他学術会議資料等)

  • 53歳下顎側方偏位症例に対し外科的矯正治療を行った1例

    塩屋園 敦, 立石 千鶴, 長谷川 巧実, 今井 佑輔, 竹内 純一郎, 鈴木 泰明, 古土井 春吾, 澁谷 恭之, 古森 孝英

    2013年05月, 日本顎変形症学会雑誌, 23 (2号), 174, 日本語

    [査読有り]

    研究論文(その他学術会議資料等)

  • Yasuyuki Shibuya, Takumi Hasegawa, Masaya Akashi, Takashi Shigeta, Tsutomu Minamikawa, Takahide Komori

    Purpose: The purpose of this study is to know an outcome of the treatment for oral squamous cell carcinoma having more than 10 unilateral pathologically positive lymph nodes (pN)s. Patients and Methods: We reviewed 212 primary cases of oral squamous cell carcinoma that visited our hospital from January 1999 to December 2011 and underwent resection of the primary tumor with neck dissection. The patients were classified into 3 categories of pN0, pN1-9, and pN >= 10 cases, and an outcome of pN >= 10 was studied specifically in comparison with the other categories. Results: Of the patients studied, 103 cases (48.6%) were pN0, 103 cases (48.6%) were pN1-9, and 6 cases (2.8%) were pN >= 10. The pN >= 10 group, which had positive nodes of 10 to 30 on the ipsilateral side, was predominantly male and had no cases of well-differentiated squamous cell carcinoma. Extracapsular spread (ECS) was found in all pN >= 10 cases, and postoperative distant metastasis occurred in cases with ECS, which was localized in levels higher than III. The proportion of distant metastasis was 0% (0 cases) in pN0, 8.7% (9 cases) in pN1-9, and 66.7% (4 cases) in pN10. Overall survival rate in pN >= 10 was 20.8%, whereas it was 89.0% in pN0, and 34.9% in pN1-9. Conclusion: Oral squamous cell carcinoma having multiple neck metastases (pN >= 10) had a poor prognosis because the proportion of distant metastasis was higher in comparison with the other groups of pN0 and pN1-9. (C) 2013 American Association of Oral and Maxillofacial Surgeons J Oral Maxillofac Surg 71:793-797, 2013

    W B SAUNDERS CO-ELSEVIER INC, 2013年04月, JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 71 (4), 793 - 797, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Y. Shibuya, S. Ishida, M. Kobayashi, T. Hasegawa, K. Nibu, T. Komori

    The purpose of this study was to identify the risk factors associated with the masticatory dysfunction after maxillectomy using a colour-changing chewing gum. Thirty-nine patients who underwent maxillectomy between January 2002 and May 2010 in the Department of Kobe University Hospital were recruited for this study. There were 20 male and 19 female subjects, with a median age of 73 center dot 3years (range of 4490) at the time of surgery. The intra-oral conditions after maxillectomy were classified by HS classification, and the masticatory function was evaluated by a colour-changing chewing gum and the results of a modified Sato's questionnaire. The scores of the colour-changing gum were closely correlated with the scores of the modified Sato's questionnaire (r=0 center dot 661, P<0 center dot 01). A logistic regression analysis with the outcome variable of the gum test <4 demonstrated that significant predictors for the masticatory dysfunction were the number of anchor teeth 2 and a soft palate defect. A colour-changing gum was found to be useful for evaluating the post-operative masticatory function, and it was important to conserve the anchor teeth and the soft palate to avoid masticatory dysfunction.

    WILEY-BLACKWELL, 2013年03月, JOURNAL OF ORAL REHABILITATION, 40 (3), 191 - 198, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Hasegawa T, Ri S, Umeda M, Komatsubara H, Kobayashi M, Shigeta T, Yoshitomi I, Ikeda H, Shibuya Y, Asahina I, Komori T

    Introduction: In this study, we investigated whether such a discontinuation of oral bisphosphonate (BP) for 3 months might influence the incidence of BP-related osteonecrosis of the jaw (BRONJ) and wound healing after tooth extraction in patients receiving oral BP therapy. Material and methods: There were a total of 434 teeth in 201 patients (18 males and 183 females). The patients were divided into two groups depending on whether or not they underwent a 3-month discontinuation of BP therapy (BP- and BP+) before tooth extraction. In this observational study investigated delayed wound healing after tooth extraction in patients receiving oral BP therapy. Results: In all cases of the BP- group, there were no BRONJ although there was delayed wound healing in two cases. However, in one case of the BP+ group, oral BP was continued because it was deemed high risk to discontinue treatment by the patient's physician. In this case, an intraoral fistula was still present with bone exposure at 120 weeks after extraction (BRONJ stage 1). Conclusion: This study supports the idea of a drug holiday and encourages further clinical research on this topic of tooth extraction in patients receiving oral BP therapy. © 2012 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights.

    2013年, J Craniomaxillofac Surg., 41 (7), 558 - 563.

    研究論文(学術雑誌)

  • 李 進彰, 重田 崇至, 長谷川 巧実, 高田 直樹, 吉武 賢, 古森 孝英

    Dedifferentiated carcinoma is defined as the abrupt transformation of a low-grade, well-differentiated tumor into a tumor of high malignancy. Because the transformed cells are highly aggressive, recurrence and metastasis frequently occur.
    We report a case of dedifferentiated carcinoma in adenoid cystic carcinoma of the submandibular gland with multiple metastases to the cervical lymph nodes and distant metastasis to the ileum.
    A 73-year-old woman was referred to our hospital because of submandibular gland carcinoma with multiple lymph node metastases. In another clinic, adenocarcinoma was pathologically diagnosed on lymph node biopsy. A surgically resected specimen showed that the tumor was composed of both a cribriform pattern of conventional low-grade adenoid cystic carcinoma and a high-grade dedifferentiated carcinoma. The lesion was thus a dedifferentiated carcinoma. Lymph node metastases contained dedifferentiated components. One year and a half after the operation, the tumor metastasized to the small intestine (ileum) . The tumor in the ileum was also pathologically diagnosed as a high-grade dedifferentiated carcinoma.

    Japanese Society of Oral and Maxillofacial Surgeons, 2013年, 日本口腔外科学会誌, 59 (9), 588 - 592, 日本語

    [査読有り]

    研究論文(学術雑誌)

  • 下顎枝垂直骨切り術における骨性治癒形態の経時的観察

    長谷川巧実, 古土井春吾, 渋谷恭之, 古森孝英

    2012年08月, 日本顎変形症学会雑誌, 22 (3号), 216 - 222, 日本語

    [査読有り]

    研究論文(学術雑誌)

  • 口蓋に発生した嚢胞腺癌の1例

    渋谷恭之, 長谷川巧実, 古森孝英

    2012年07月, 日本口腔科学会雑誌, 61 (3号), 316, 日本語

    [査読有り]

    研究論文(その他学術会議資料等)

  • 下顎枝垂直骨切り術術後における口腔内・口腔外知覚神経麻痺の経時的変化に関する検討

    長谷川巧実, 古土井春吾, 渋谷恭之, 古森孝英

    2012年05月, 日本顎変形症学会雑誌, 22 (2号), 107, 日本語

    [査読有り]

    研究論文(その他学術会議資料等)

  • Takumi Hasegawa, Masahiko Miwa, Yoshitada Sakai, Takahiro Nikura, Sang Yang Lee, Keisuke Oe, Takashi Iwakura, Masahiro Kurosaka, Takahide Komori

    Purpose: We hypothesized that cells within the mandibular fracture hematoma played an important role in mandibular fracture healing. The objective of this study was to analyze cells in human mandibular fracture hematoma. Patients and Methods: We isolated and analyzed human mandibular fracture hematoma cells (MHCs) and investigated whether MHCs had multilineage mesenchymal differentiation capacity in vitro, similar to bone marrow stromal cells (BMSCs). Results: Cell-surface markers showed that the adherent MHCs expressed mesenchymal stem cell-related markers, namely CD29, CD44, CD105, and CD166, while lacking hematopoietic markers CD14, CD34, CD45, and CD133. The proliferative potential, osteogenic potential, and adipogenic potential of MHCs were comparable to those of BMSCs. In contrast, the chondrogenic potential of MHCs was inferior to that of BMSCs. Conclusions: The role of the mandibular fracture hematoma could be as a presumptive local reservoir for osteogenic progenitors and thus contribute to intramembranous bone healing. Our findings may provide new insights into the mechanism of intramembranous bone healing in membranous bone fractures. (c) 2012 American Association of Oral and Maxillofacial Surgeons J Oral Maxillofac Surg 70:599-607, 2012

    W B SAUNDERS CO-ELSEVIER INC, 2012年03月, JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 70 (3), 599 - 607, 英語

    [査読有り]

    研究論文(学術雑誌)

  • 重田崇至, 梅田正博, 澁谷恭之, 古森孝英, 長谷川巧実

    抗血栓療法継続下で抜歯を施行した患者の出血性合併症に関する臨床的検討を行った。循環器系疾患の既往によりワルファリンが投与され、ワルファリン継続下に抜歯が行われた282例を対象とした。ワルファリン単独投与168例、ワルファリンと抗血小板薬の併用114例であった。抜歯は282例で合計589本に施行した。抜歯後出血率は25例(8.9%)に認め、多くは抜歯当日および翌日に生じた。ワルファリン単独群とワルファリンと抗血小板薬併用群の後出血率に有意差は認めなかった。PT-INR値が高いほど後出血の頻度が高くなる傾向がみられた。後出血に対して全例局所止血処置で対応可能であった。術後に投与したNSAIDsや抗菌薬投与によるPT-INR値の変動は明らかではなかった。PT-INR値を至適治療域にコントロールされた状態では、ワルファリン継続下で抜歯を行うことが可能であると思われた。

    (NPO)日本口腔科学会, 2012年01月, 日本口腔科学会雑誌, 61 (1号), 1 - 7, 日本語

    [査読有り]

    研究論文(学術雑誌)

  • 抗凝固療法継続下で抜歯を施行した患者の出血性合併症に関する臨床的検討

    重田崇至, 梅田正博, 渋谷恭之, 南川勉, 長谷川巧実, 古森孝英

    2012年01月, 日本口腔科学会雑誌, 61 (1号), 150, 日本語

    [査読有り]

    研究論文(その他学術会議資料等)

  • 長谷川 巧実, 李 進彰, 後藤 育子, 吉武 賢, 中野 沙織, 梅田 正博, 古森 孝英

    (NPO)日本口腔科学会, 2012年01月, 日本口腔科学会雑誌, 61 (1), 131 - 132, 日本語

  • Analysis of the 619 Brånemark System TiUnite implants: a retrospective study

    Shibuya Y, Takata N, Takeuchi J, Tsuji K, Ishida S, Kobayashi M, Suzuki H, Hasegawa T, Kamae I, Komori T

    The purpose of this retrospective study was to determine the outcome of Brånemark System TiUnite® implants (Nobel Biocare/Sweden), and to identify the risk factors associated with implant failure. A total of 151 patients (83 maxillae and 91 mandibles) received 619 implants from July 2003 until May 2010. The patients included 86 males and 65 females, with a median age of 51.6 years and an age range of 16 to 90 years at the time of implant surgery. Seventeen maxillae and 16 mandibles were completely edentulous, and 66 maxillae and 75 mandibles were partially edentulous. All the patients were followed until June 2011. Among the 619 implants, 9 maxillary implants and 8 mandibular implants were unsuccessful. The overall survival rate was 96.82%. A logistic regression analysis identified that a history of steroid treatment, application of a dento-maxillary prosthesis, a lack of mechanical coupling between the implants, and the length of the implants (≤8.5mm) were significant predictors of implant failure.

    2012年, Kobe J Med Sci, 58 (1), E19 - E28, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Takumi Hasegawa, Shinshou Ri, Masahiro Umeda, Takahide Komori

    Objective. In this study, we investigated the multivariate relationships among risk factors and hypoesthesia of the lower lip. Study design. Various risk factors of hypoesthesia of the lower lip after mandibular third molar extraction were investigated by univariate and multivariate analyses. Results. Applying the logistic regression model and forward stepwise algorithms, canal observed, remarkable hemorrhage, loss of the white line of the root, diversion of the canal, and close relationship of the roots to the inferior alveolar nerve were identified as significant variables. Conclusions. Procedure-related factors during surgery, such as canal observed and remarkable hemorrhage, and radiographic signs, such as loss of the white line of the root, diversion of the canal, and close relationship of the roots to the inferior alveolar nerve, were high risk factors of hypoesthesia of lower lip after extraction. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011;111:e1-e7)

    MOSBY-ELSEVIER, 2011年06月, ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY, 111 (6), E1 - E7, 英語

    [査読有り]

    研究論文(学術雑誌)

  • 長谷川 巧実, 梅田 正博, 吉武 賢, 高橋 英哲, 山田 周子, 古森 孝英

    65歳女性。右側下顎前歯部に発生した軟骨肉腫の根治療法目的で紹介となった。初診時、口腔内所見では右側下顎第2歯の抜歯部に無痛性、表面平滑な骨様硬の軽度膨隆が認められ、精査の結果、下顎骨軟骨肉腫と診断、全身麻酔下に下顎骨辺縁切除術が施行された。その結果、病理組織学的に低悪性度の軟骨肉腫(Grade I)で、術後2年経過現在、再発や転移は認められず、経過良好である。

    (公社)日本口腔外科学会, 2011年06月, 日本口腔外科学会雑誌, 57 (6), 355 - 359, 日本語

  • Oe K, Ueha T, Sakai Y, Niikura T, Lee SY, Koh A, Hasegawa T, Tanaka M, Miwa M, Kurosaka M

    In Europe, carbon dioxide therapy has been used for cardiac disease and skin problems for a long time. However there have been few reports investigating the effects of carbon dioxide therapy on skeletal muscle. Peroxisome proliferators-activated receptor (PPAR)-gamma coactivator-1 (PGC-1 alpha) is up-regulated as a result of exercise and mediates known responses to exercise, such as mitochondrial biogenesis and muscle fiber-type switching, and neovascularization via up-regulation of vascular endothelial growth factor (VEGF). It is also known that silent mating type information regulation 2 homologs 1 (SIRT1) enhances PGC-1 alpha-mediated muscle fiber-type switching. Previously, we demonstrated transcutaneous application of CO2 increased blood flow and a partial increase of O-2 pressure in the local tissue known as the Bohr effect. In this study, we transcutaneously applied CO2 to the lower limbs of rats, and investigated the effect on the fast muscle, tibialis anterior (TA) muscle. The transcutaneous CO2 application caused: (1) the gene expression of PGC-1 alpha, silent mating type information regulation 2 homologs 1 (SIRT1) and VEGF, and increased the number of mitochondria, as proven by real-time PCR and immunohistochemistry, (2) muscle fiber switching in the TA muscle, as proven by isolation of myosin heavy chain and ATPase staining. Our results suggest the transcutaneous application of CO2 may have therapeutic potential for muscular strength recovery resulting from disuse atrophy in post-operative patients and the elderly population. (C) 2011 Elsevier Inc. All rights reserved.

    ACADEMIC PRESS INC ELSEVIER SCIENCE, 2011年04月, Biochemical and biophysical research communications, 407 (1), 148 - 152, 英語

    [査読有り]

    研究論文(学術雑誌)

  • 吉武 賢, 梅田 正博, 村田 真穂, 重田 崇至, 長谷川 巧実, 井堂 信二郎, 李 進彰, 古森 孝英

    (NPO)日本口腔科学会, 2011年01月, 日本口腔科学会雑誌, 60 (1), 60 - 60, 日本語

  • 長谷川 巧実, 李 進彰, 梅田 正博, 有馬 宏美, 高橋 英哲, 重田 崇至, 井堂 信二郎, 古森 孝英

    (NPO)日本口腔科学会, 2011年01月, 日本口腔科学会雑誌, 60 (1), 84 - 85, 日本語

  • 村田 真穂, 梅田 正博, 竹内 純一郎, 鈴木 泰明, 古森 孝英, 長谷川 巧実, 井堂 信二郎, 李 進彰

    (NPO)日本口腔科学会, 2011年01月, 日本口腔科学会雑誌, 60 (1), 186 - 186, 日本語

  • ミニシンポジウム/抗血栓療法 抗血栓療法継続下での歯科観血的処置後の出血の現状と対策

    重田 崇至, 李 進彰, 長谷川 巧実, 井堂 信二郎, 梅田 正博, 村田 真穂, 南川 勉, 古土井 春吾, 渋谷 恭之, 古森 孝英

    (一社)日本有病者歯科医療学会, 2010年12月, 有病者歯科医療, 19 (3), 197 - 198, 日本語

  • 長谷川 巧実, 李 進彰, 梅田 正博, 有馬 宏美, 高橋 英哲, 重田 崇至, 井堂 信二郎, 古森 孝英

    2006年4月〜2009年3月迄の3年間に歯科口腔外科で下顎埋伏智歯を抜歯した1764例2395本中、パノラマX線およびCTで撮影した198例(男性83例、女性115例、18〜71歳・平均36.2歳)329本を対象に、下顎埋伏智歯について、CT画像とパノラマX線画像の比較、知覚鈍麻との関連性について検討した。対象の329歯中23歯(7.0%)に術後1ヵ月でオトガイ神経鈍麻を認めた。鈍麻を認めた症例では術翌日からステロイド経静脈投与とATP製剤およびビタミンB12製剤が処方されていた。23歯中10歯は1〜3ヵ月で、9歯は4〜6ヵ月で、1歯は9ヵ月で知覚鈍麻は消失していたが、残り3歯(0.9%)は経過観察が可能であった7ヵ月、11ヵ月、12ヵ月後に知覚鈍麻が残存していた。パノラマX線画像と、CT画像による歯根と下顎管との位置関係は判定の結果、329歯中206歯(62.6%)で不一致であった。同じ1型でもCTの方がより知覚鈍麻の予測が可能であった。知覚鈍麻が生じた症例は全てCT画像において歯根と下顎管の距離が0mmで、中でも下顎管が歯根の舌側或いは根尖間に存在している場合に知覚鈍麻の発生率が舌側24.0%、根尖間100.0%と高くなっていた。パノラマX線で智歯歯根と下顎管が近接していると判定された症例では、CTを撮影した上で、抜歯の必要性と知覚鈍麻発生の可能性を加味した抜歯の決定を行うことが望ましいと思われた。

    (公社)日本口腔外科学会, 2010年10月, 日本口腔外科学会雑誌, 56 (10), 568 - 576, 日本語

  • NBI、ルゴール染色の併用により、早期に発見し得た舌表在癌の検討

    長谷川 巧実, 李 進彰, 井堂 信二郎, 重田 崇至, 吉武 賢, 中野 沙織, 梅田 正博, 古森 孝英

    (公社)日本口腔外科学会, 2010年09月, 日本口腔外科学会雑誌, 56 (Suppl.), 97 - 97, 日本語

  • 李 進彰, 井堂 信二郎, 重田 崇至, 長谷川 巧実, 中野 沙織, 梅田 正博, 古森 孝英

    (一社)日本障害者歯科学会, 2010年09月, 障害者歯科, 31 (3), 558 - 558, 日本語

  • T. Hasegawa, M. Miwa, Y. Sakai, T. Niikura, S. Y. Lee, K. Oe, T. Iwakura, M. Kurosaka, T. Komori

    Bone marrow stromal cells (BMSCs)/beta-tricalcium phosphate (beta-TCP) composites have attracted a great deal of attention in bone tissue engineering. If more effective bone regeneration is to be achieved, efficient cell-seeding systems need to be clarified. In this study, we investigated the number of cells contained in composites, and the in vitro/vivo osteogenic differentiation capacity of composites using 4 conventional systems of seeding rat BMSCs into beta-TCP: soak, low-pressure, pipette, and syringe systems. The highest number of cells was contained in the composites from the syringe group. Moreover, after two-week osteogenic induction in vitro, the composites in the syringe group exhibited the highest osteogenic potential, which continued at 8 weeks after subcutaneous implantation in vivo. Our results indicated that efficient and appropriate cell-seeding could improve in vitro/vivo bone formation in composites and thus make a potential clinical contribution to successful bone tissue engineering. Abbreviations: BMSCs, bone marrow stromal cells; beta-TCP, beta-tricalcium phosphate; S-D, Sprague-Dawley; kPa, kilopascal; ALP, alkaline phosphatase; N, Newton; DNA, deoxyribonucleic acid; OCN, osteocalcin; ANOVA, analysis of variance; PLSD, protected least-significant difference; and HE, hematoxylin and eosin.

    SAGE PUBLICATIONS INC, 2010年08月, JOURNAL OF DENTAL RESEARCH, 89 (8), 854 - 859, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Keisuke Oe, Masahiko Miwa, Kouki Nagamune, Yoshitada Sakai, Sang Yang Lee, Takahiro Niikura, Takashi Iwakura, Takumi Hasegawa, Nao Shibanuma, Yutaka Hata, Ryosuke Kuroda, Masahiro Kurosaka

    Composites of bone marrow stromal cells (BMSCs)/beta-tricalcium phosphate (beta-TCP) have been increasingly used as bone substitutes and studied as a bone graft model for bone tissue engineering. The number of seeded cells in the composites is a crucial factor for achieving successful bone tissue regeneration. In this study, we showed that the actual number of cells in BMSC/beta-TCP composites 24 h after seeding at densities of 1.0 x 10(6), 1.5 x 10(6), 2.0 x 10(6), and 1.0 x 10(7) cells/mL was 2.8 +/- 1.5 x 10(5), 3.4 +/- 2.3 x 10(5), 3.7 +/- 1.0 x 10(5), and 3.7 +/- 1.8 x 10(5), respectively, indicating that even when one regular cell-seeding concentration was applied to the beta-TCP, the actual number of cells in the individual BMSC/beta-TCP composites varied considerably. In clinical setting, it is important to choose composites containing an appropriate number of cells before implanting them to patients. In an attempt to searching for the practical tools that can nondestructively evaluate the actual number of cells in beta-TCP after cell seeding, we looked into ultrasound system and developed a nondestructive and quantitative ultrasound device. We successfully demonstrated for the first time that ultrasound amplitude effectively responded to the quantity of BMSC/beta-TCP composites after 24-h cell seeding, and was well correlated to the actual number of cells contained (r = 0.903). Using this ultrasound device, orthopedic surgeons can choose composites that contain favorable number of cells before implantation. Our device could be a valuable, convenient, and nondestructive tool for future bone tissue engineering.

    MARY ANN LIEBERT, INC, 2010年06月, TISSUE ENGINEERING PART C-METHODS, 16 (3), 347 - 353, 英語

    [査読有り]

    研究論文(学術雑誌)

  • 吉武 賢, 梅田 正博, 長谷川 巧実, 西 周子, 南川 勉, 古森 孝英

    (NPO)日本口腔科学会, 2010年03月, 日本口腔科学会雑誌, 59 (2), 99 - 99, 日本語

  • 李 進彰, 井堂 信二郎, 重田 崇至, 長谷川 巧実, 有馬 宏美, 梅田 正博, 澁谷 恭之, 田中 武彦, 中神 正博, 麻柄 真也, 長谷川 雅一, 鎌田 真砂史, 古森 孝英

    (一社)日本障害者歯科学会, 2009年09月, 障害者歯科, 30 (3), 221 - 221, 日本語

  • T. Hasegawa, M. Miwa, Y. Sakai, T. Niikura, M. Kurosaka, T. Komori

    The haematoma occurring at the site of a fracture is known to play an important role in bone healing. We have recently shown the presence of progenitor cells in human fracture haematoma and demonstrated that they have the capacity for multilineage mesenchymal differentiation. There have been many studies which have shown that low-intensity pulsed ultrasound (LIPUS) stimulates the differentiation of a variety of cells, but none has investigated the effects of LIPUS on cells derived from human fracture tissue including human fracture haematoma-derived progenitor cells (HCs). In this in vitro study, we investigated the effects of LIPUS on the osteogenic activity of HCs. Alkaline phosphatase activity, osteocalcin secretion, the expression of osteoblast-related genes and the mineralisation of HCs were shown to be significantly higher when LIPUS had been applied but without a change in the proliferation of the HCs. These findings provide evidence in favour of the use of LIPUS in the treatment of fractures.

    BRITISH EDITORIAL SOC BONE JOINT SURGERY, 2009年02月, JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME, 91B (2), 264 - 270, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Iwakura T, Miwa M, Sakai Y, Niikura T, Lee SY, Oe K, Hasegawa T, Kuroda R, Fujioka H, Doita M, Kurosaka M

    Hypertrophic nonunion usually results from insufficient fracture stabilization. Therefore, most hypertrophic nonunions simply require the stabilization of the nonunion site. However, the reasons why union occurs without treating the nonunion site directly is not well understood biologically. In this study, we hypothesized that the intervening tissue at the hypertrophic nonunion site (nonunion tissue) could serve as a reservoir of mesenchymal progenitor cells and investigated whether the cells derived from nonunion tissue had the capacity for multilineage mesenchymal differentiation. After nonunion tissue was obtained, it was cut into strips and cultured. Homogenous fibroblastic adherent cells were obtained. Flow cytometry revealed that the adherent cells were consistently positive for mesenchymal stem cell related markers CD13, CD29, CD44, CD90, CD105, CD166, and negative for the hematopoietic markers CD14, CD34, CD45, and CD133, similar to control bone marrow stromal cells. In the presence of lineage-specific induction factors, the adherent cells differentiated in vitro into osteogenic, chondrogenic, and adipogenic cells. These results demonstrated for the first time that hypertrophic nonunion tissue contains multilineage mesenchymal progenitor cells. This suggests that hypertrophic nonunion tissue plays an important role during the healing process of hypertrophic nonunion by serving as a reservoir of mesenchymal cells that are capable of transforming into cartilage and bone forming cells.

    2009年02月, Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 27 (2), 208 - 215, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Two cases of masticator space abscess initially diagnosed as temporomandibular joint disorder.

    Hasegawa T, Shibuya Y, Kuroki S, Takeuchi J, Yokoo S, Umeda M, Komori T

    2008年, Kobe Journal of Medical Sciences, 54 (3), 163 - 168.

  • 舌および頸部に発生し嚥下障害をきたした巨大な血管奇形の1例

    白坂 渉, 宗本 幸子, 志水 素子, 重田 崇至, 長谷川 巧実, 梅田 正博, 古森 孝英

    (公社)日本口腔外科学会, 2007年12月, 日本口腔外科学会雑誌, 53 (12), 758 - 758, 日本語

  • 当科における高度先進医療「インプラント義歯」の臨床統計的検討

    長谷川 巧実, 澁谷 恭之, 真砂 洋, 宗本 幸子, 村田 真穂

    (公社)日本口腔インプラント学会, 2007年03月, 日本口腔インプラント学会誌, 20 (1), 139 - 140, 日本語

  • 下顎骨転移性腫瘍の5例

    小松原 秀紀, 梅田 正博, 長谷川 巧実, 尾島 泰公, 南川 勉, 重田 崇至, 古森 孝英

    (公社)日本口腔外科学会, 2006年09月, 日本口腔外科学会雑誌, 52 (Suppl.), 76 - 76, 日本語

  • Eiji Iwata, Akira Tachibana, Junya Kusumoto, Takumi Hasegawa, Ryo Kadoya, Yui Enomoto, Naoki Takata, Masaya Akashi

    PURPOSE: The purpose of this study was to investigate the risk factors associated with post-extraction persistent bleeding in patients on warfarin or direct-acting oral anticoagulants (DOACs) and the ability of risk scores to predict post-extraction bleeding. METHODS: Three hundred ninety-one patients taking warfarin or DOACs underwent tooth extractions. Various risk factors for post-extraction bleeding, including number of tooth extraction, with antiplatelet therapy, and risk scores, were investigated by univariate and multivariate analyses. A post-extraction bleeding was classified into grades 1-3. RESULTS: The incidence of post-extraction bleeding was 26.8% (77 out of 287 patients; grade 1: 63, grade 2:14) in patients taking warfarin, and 26.0% (27 out of 104 patients; grade 1: 20, grade 2:7) in patients taking warfarin DOACs. Multivariate analyses showed that multiple teeth extractions and HAS-BLED scores (above 3 points) in patients taking warfarin, and only multiple teeth extractions in patients taking DOAC, were significantly associated with post-extraction bleeding, respectively. CONCLUSION: Most of the post-extraction bleedings were grade 1, which can be stopped by eligibly pressing gauze by surgeons. If patients taking anticoagulants are scheduled to undergo multiple teeth extractions or their HAS-BLED score are above 3 points (if warfarin), we recommend informing patients risk of post-extraction bleeding before operation, taking carefully hemostasis, and instructing patients to bite down accurately on the gauze for longer than usual.

    2022年01月19日, Oral and maxillofacial surgery, 英語, 国際誌

    研究論文(学術雑誌)

  • 筧 康正, 永井 洋士, 長谷川 巧実, 明石 昌也

    わが国における臨床研究環境は近年著しく変化している。なかでも2018年4月1日に臨床研究法が施行されたことは大きな転換点といえる。その背景として2013年から2014年にかけて、ディオバン事件を代表とする臨床研究に関する不適切な事案が複数生じたことが挙げられる。それらの臨床研究では、複数の大学機関が関連していたデータ操作・不透明な奨学寄附金を通じた研究者と製薬企業との関係性が大きくクローズアップされ、社会問題化した。これらの研究不正に鑑みて、厚労省は、臨床研究の信頼の回復のためには法規制が必要との結論に達し、倫理指針の改定・厳格化を経て臨床研究法施行の運びとなった。臨床研究に関わる全てのものにとって本法の要請を理解し、適切に対応することが求められている一方で、本法を理解するための文書類の多さや手続きの煩雑さなど、研究者の負担が大きく増えたことから、臨床試験の停滞や萎縮を招いている。本法の大きな特徴として、研究責任医師に臨床研究の責任が集約されたこと、研究者は厚労省が認定した認定臨床研究審査委員会を通して試験計画を厚労省に届けること、利益相反の流れが詳細に定められたことなどが挙げられる。本報告では臨床研究倫理における臨床研究法成立までの臨床研究環境の変化について述べたうえで、臨床研究法について概説する。(著者抄録)

    (一社)日本口腔腫瘍学会, 2021年12月, 日本口腔腫瘍学会誌, 33 (4), 159 - 163, 日本語

  • Rika Amano-Iga, Takumi Hasegawa, Daisuke Takeda, Aki Murakami, Nanae Yatagai, Izumi Saito, Satomi Arimoto, Yasumasa Kakei, Akiko Sakakibara, Masaya Akashi

    INTRODUCTION:  Delayed wound healing after surgery lowers the long-term quality of a patient's life and leads to discomfort and pain. However, treatments for wound healing are often difficult and have not yet been fully established. In this study, we investigated the effect of a special paste that can be administered transdermally and holds a non-gaseous carbon dioxide (CO2) source in its carrier, which can be applied to the head and neck region for wound healing in a rat skin defect model. METHODS: Forty-eight Sprague Dawley rats were randomized into control and CO2 groups. We punched a 6.2-mm wound on the back of each rat. The control rats were left untreated, whereas rats in the CO2 group were treated with the CO2 paste every day after surgery. We evaluated wound healing 3, 7, 14, and 21 days after wounding by analyzing the diameter of the wound, gene expression of inflammatory markers vascular endothelial growth factor (VEGF), transforming growth factor (TGF)-β, hypoxia-inducible factor (HIF)-1α, interleukin (IL)-1β, and IL-6 using quantitative real-time polymerase chain reaction, hematoxylin and eosin, and immunohistochemical staining patterns. RESULTS: Rats in the CO2 group showed accelerated wound healing compared to those in the control group. Furthermore, VEGF and TGF-β were overexpressed, whereas HIF-1α, IL-1β, and IL-6 were downregulated in the rats treated with CO2. Immunohistochemical analysis also revealed similar patterns of expression. CONCLUSION: Taken together, the CO2 paste promoted wound healing by regulating the hypoxic environment, reducing inflammation, and accelerating angiogenesis.

    2021年11月, Cureus, 13 (11), e19518, 英語, 国際誌

    研究論文(学術雑誌)

  • 口腔ケアのエビデンスを検証するためにはどのような研究をすればよいのか アカデミア臨床研究環境のこれまで 臨床研究法施行の背景

    筧 康正, 長谷川 巧実, 明石 昌也

    (一社)日本口腔ケア学会, 2020年09月, 日本口腔ケア学会雑誌, 14 (3), 53 - 54, 日本語

  • 大腸癌術後合併症に対する周術期口腔機能管理の予防効果に関する多施設共同研究

    延原 浩, 五月女 さき子, 林田 咲, 村田 真穂, 梅田 正博, 長谷川 巧実, 明石 昌也, 山田 慎一, 栗田 浩, 小西 尚晃, 中原 寛和, 上田 順宏, 下辻 寛子, 桐田 忠昭, 中村 知寿, 渋谷 恭之, 山口 泰平, 森 和代

    (一社)日本口腔ケア学会, 2020年09月, 日本口腔ケア学会雑誌, 14 (3), 122 - 122, 日本語

  • Hirokazu Komatsu, Tatsuya Furukawa, Keisuke Iritani, Shun Tatehara, Miki Takahashi, Shinobu Iwaki, Yasumasa Kakei, Takumi Hasegawa, Masanori Teshima, Hirotaka Shinomiya, Naoki Otsuki, Kazunobu Hashikawa, Naomi Kiyota, Ryohei Sasaki, Masaya Akashi, Ken-Ichi Nibu

    OBJECTIVE: The blowing time ratio, which is the ratio of the blowing time when the nostrils are open and closed, is significantly correlated with velopharyngeal pressure, not only during speech but also during swallowing. This study aimed to further evaluate the usefulness of the blowing time ratio as a screening tool to evaluate the swallowing pressure of patients treated for oral and oropharyngeal cancers using high-resolution manometery (HRM). METHODS: Ten patients treated for oral or oropharyngeal cancer were recruited for this study. Swallowing pressures at the velopharynx, oropharynx, and upper esophageal sphincter (UES) were measured using HRM. Their correlations with the blowing time ratio were analyzed. RESULTS: The blowing time ratio was significantly correlated with the swallowing pressures of the oropharynx (CC = 0.815, p = 0.004) and the velopharynx (CC = 0.657, p = 0.039), but not of the UES. CONCLUSIONS: The present results further support our previous finding that the blowing time ratio is a useful screening tool to evaluate velopharyngeal and oropharyngeal swallowing pressures in patients treated for oral and oropharyngeal cancer.

    2022年06月, Auris, nasus, larynx, 49 (3), 477 - 483, 英語, 国際誌

    研究論文(学術雑誌)

  • Yasumasa Kakei, Takeshi Ioroi, Takahiro Ito, Yutaro Okazaki, Takumi Hasegawa, Ikuko Yano, Masaya Akashi

    BACKGROUND: Extraction of mandibular third molars is one of the most commonly performed oral surgical procedures, and nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for pain management. Oral NSAIDs are associated with adverse events such as gastrointestinal disorders, renal and hepatic dysfunction, and platelet dysfunction. Topical analgesics have been proposed as alternatives to oral and injectable medications to safely improve postoperative pain relief. We will conduct a single-center, placebo-controlled, double-blind, randomized crossover trial to assess the pain-relieving effect of an ibuprofen-containing gargle in patients undergoing extraction of mandibular third molars when compared with a placebo gargle. OBJECTIVE: This will be the first clinical study to compare the efficacy of an ibuprofen gargle with that of a placebo for relieving postoperative pain in addition to loxoprofen after mandibular third molar extraction. METHODS: This study will be performed at Kobe University Hospital. Participants (N=40) will be randomized equally to 1 of 2 groups. The ibuprofen-placebo group will receive an ibuprofen gargle on postoperative day (POD) 1 and a placebo gargle on POD 2. The placebo-ibuprofen group will receive a placebo gargle on POD 1 and an ibuprofen gargle on POD 2. Both groups will receive ibuprofen gargles on PODs 3-5 at least once daily. The primary objective is to estimate the within-subject difference on a visual analog scale (VAS) before and 5 minutes after using the ibuprofen or placebo gargle on PODs 1 and 2. The secondary objectives are to estimate the within-subject differences in ΔVAS before and 15 minutes after using the ibuprofen or placebo gargle on PODs 1 and 2, ΔVAS before and 5 or 15 minutes after using the ibuprofen gargle on PODs 3-5, overall efficacy (self-completion, 5 scales) on PODs 1-5, daily frequency of use (ibuprofen or placebo gargle and analgesics) on PODs 1-7, and the occurrence of adverse events. RESULTS: The Certified Review Board of Kobe University approved the study. The intervention was implemented in May 2021. For the primary analysis, we will calculate the mean and SD of ΔVAS5 on PODs 1 and 2 and the within-study difference in ΔVAS5. The treatment effect will be estimated by dividing the mean ΔVAS5 in the within-subject difference by 2 and calculating the P value using an unpaired t test. For the secondary analysis, we will calculate the mean and SD of ΔVAS15 on PODs 1 and 2 and the within-study difference in ΔVAS15. The treatment effect will be estimated as in the primary analysis. CONCLUSIONS: This trial will provide exploratory evidence of the efficacy and safety of an ibuprofen gargle for pain reduction after mandibular third molar extraction. TRIAL REGISTRATION: Japan Registry of Clinical Trials jRCTs051210022; https://tinyurl.com/39ej23zu. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/35533.

    2022年05月16日, JMIR research protocols, 11 (5), e35533, 英語, 国際誌

    研究論文(学術雑誌)

  • Hiroshi Nobuhara, Yasuhiro Matsugu, Sakiko Soutome, Saki Hayashida, Takumi Hasegawa, Masaya Akashi, Shin-Ichi Yamada, Hiroshi Kurita, Hirokazu Nakahara, Miyuka Nakahara, Nobuhiro Ueda, Tadaaki Kirita, Tomohisa Nakamura, Yasuyuki Shibuya, Kazuyo Mori, Taihei Yamaguchi

    BACKGROUND: Surgical site infection is a common postoperative complication of colorectal cancer surgery, and surgical site infection increases medical costs, prolongs hospitalization, and worsens long-term prognosis. Perioperative oral care has been reported to be effective in preventing postoperative pneumonia, although there are only a few reports on its effectiveness in preventing surgical site infection. This study aimed to determine the role of perioperative oral care in surgical site infection prevention after colorectal cancer surgery. METHODS: In this study, 1,926 patients with colorectal cancer from 8 institutions were enrolled; 808 patients (oral care group) received perioperative oral care at the hospital's dental clinic, and 1,118 (control group) did not receive perioperative oral care. The data were matched by propensity score to reduce bias. Ultimately, a total of 1,480 patients were included in the analysis. RESULTS: The incidence of surgical site infection was significantly lower in the oral care group than in the control group (8.4% vs 15.7%, P < .001). Multivariate logistic regression analysis revealed 4 independent risk factors for surgical site infection: low albumin level, rectal cancer, blood loss, and lack of perioperative oral care. Lack of perioperative oral care had an odds ratio of 2.100 (95% confidence interval 1.510-2.930, P < .001). CONCLUSION: These results suggest that perioperative oral care can reduce the incidence of surgical site infection after colorectal cancer resection. Perioperative oral care may have an important role in the future perioperative management of colorectal cancer as a safe and effective method of surgical site infection prevention, although further validation in prospective studies is needed.

    2022年04月06日, Surgery, 英語, 国際誌

    研究論文(学術雑誌)

  • Takumi Hasegawa, Aki Sasaki, Izumi Saito, Satomi Arimoto, Nanae Yatagai, Yujiro Hiraoka, Daisuke Takeda, Yasumasa Kakei, Masaya Akashi

    OBJECTIVES: This study aimed to retrospectively investigate the success and survival rates of dental implants used for dentomaxillary prostheses at our hospital and the risk factors associated with large bone defects. MATERIALS AND METHODS: A total of 138 external joint system implants used for dentomaxillary prostheses in 40 patients with large bone defects were included in this study. The alveolar bone at the site of implant insertion was evaluated using panoramic radiography and computed tomography. Various risk factors (demographic characteristics, dental status, and operative factors such as the employment of alveolar bone augmentation, the site, the length, and diameter of implants) for implant failure and complete implant loss were investigated using univariate and multivariate analyses. The associations between the variables and the success and survival rates of dental implants were analyzed using the multivariate Cox proportional hazard models. RESULTS: The 10-year overall success and survival rates were 81.3% and 88.4% in this study. Multivariable analysis showed that the male sex (HR 6.22), shorter implants (≤ 8.5 mm) (HR 5.21), and bone augmentation (HR 2.58) were independent predictors of success rate. Bone augmentation (HR 5.14) and narrow implants (≤ 3.3 mm) (HR 3.86) were independent predictors of the survival rate. CONCLUSION: Male sex, shorter or narrow implants, and bone augmentation were independent risk factors for dental implants used in dentomaxillary prostheses in patients with large bone defects. CLINICAL RELEVANCE: Clinicians should consider these risk factors and pay close attention to the management of these patients.

    2022年03月, Clinical oral investigations, 26 (3), 2743 - 2750, 英語, 国際誌

    研究論文(学術雑誌)

  • Nanae Yatagai, Takumi Hasegawa, Rika Amano, Izumi Saito, Satomi Arimoto, Daisuke Takeda, Yasumasa Kakei, Masaya Akashi

    INTRODUCTION: In recent years, the tumour immunosuppressive mechanism has attracted attention as a cause of tumour chemoresistance. Although chemoresistance and immunosuppression of tumours have been reported to be associated with a hypoxic environment, effective treatments to improve hypoxia in tumours have not yet been established. We have previously applied carbon dioxide (CO2) to squamous cell carcinoma and have shown that improvement in local oxygenation has an antitumour effect. However, the effects of local CO2 administration on tumour immunosuppression, chemoresistance, and combination with chemotherapy are unknown. In this study, we investigated the effects of local CO2 administration on squamous cell carcinoma and the effects of combined use with chemotherapy, focusing on the effects on tumour immunosuppressive factors. METHODS: Human oral squamous cell carcinoma (HSC-3) was transplanted subcutaneously into the back of a nude mouse, and CO2 and cisplatin were administered. After administration twice a week for a total of 4 times, tumours were collected and the expression of tumour immunosuppressive factors (PD-L1, PD-L2, and galectin-9) was evaluated using real-time polymerase chain reaction and immunostaining. RESULTS: Compared with the control group, a significant decrease in the mRNA expression of PD-L1 was observed in both, CO2-treated and combination groups. Similarly, the expression of PD-L2 and galectin-9 decreased in the CO2-treated and combination groups. Furthermore, immunostaining also showed a significant decrease in the protein expression of tumour immunosuppressive factors in the CO2-treated and combination groups. CONCLUSION: It was confirmed that the tumour immunosuppressive factors decreased due to local CO2 administration to the mouse model. CO2 administration has the potential to improve the hypoxic environment in tumours, and combined use with chemotherapy may also improve tumour immunosuppression.

    2021年, BioMed research international, 2021, 5568428 - 5568428, 英語, 国際誌

    研究論文(学術雑誌)

  • Yuka Kojima, Mitsunobu Otsuru, Takumi Hasegawa, Nobuhiro Ueda, Tadaaki Kirita, Shin ichi Yamada, Hiroshi Kurita, Yasuyuki Shibuya, Madoka Funahara, Masahiro Umeda

    Background/purpose: Osteoradionecrosis of the jaw (ORN) often occurs in patients with head and neck cancer undergoing radiotherapy (RT). It has been recommended to extract the tooth before RT that may become source of infection, but in recent years, some investigators have reported that tooth extraction before RT increase the risk of developing ORN and therefore should be avoided. The purpose of the study is to evaluate the risk factors for ORN including tooth extraction before RT. Materials and methods: This was a retrospective study of 366 patients with oral or oropharyngeal cancer who underwent RT of 50 Gy or more at six university hospitals, with follow-up of at least six months post-RT. The relationship between each factor and ORN incidence was analyzed using the Cox proportional hazard model. Results: Periapical lesions, more than 50% loss of alveolar bone, and tooth extraction after RT significantly correlated with ORN. Intensity-modulated RT showed a lower incidence than three-dimensional conformal RT, although not statistically different. Tooth extraction before RT significantly reduced ORN incidence, after adjusting the background factors using propensity score matching. Conclusion: In patients with oral or oropharyngeal cancer who underwent RT, periapical lesions, more than 50% loss of alveolar bone, and tooth extraction after RT significantly increased the risk for ORN. Infected tooth extraction before RT significantly reduced the risk.

    2022年04月, Journal of Dental Sciences, 17 (2), 1024 - 1029

    研究論文(学術雑誌)

  • Sakiko Soutome, Mitsunobu Otsuru, Maho Murata, Yumiko Kawashita, Masako Yoshimatsu, Madoka Funahara, Yoshiko Yamamura, Takumi Hasegawa, Shin-Ichi Yamada, Yuka Kojima, Hirokazu Nakahara, Yasuyuki Shibuya, Masahiro Umeda, Toshiyuki Saito

    INTRODUCTION: This is a randomised, multi-centre, open-label, phase II study to evaluate the efficacy of betamethasone valerate ointment on radiation-induced oral mucositis in patients with head and neck cancer undergoing concomitant radiotherapy with cisplatin or cetuximab. METHODS AND ANALYSIS: The trial will take place at seven hospitals in Japan. Patients will be randomised (1:1) into betamethasone and control groups after the occurrence of grade 1 oral mucositis. In the betamethasone group, patients will use betamethasone valerate ointment five times a day, in addition to usual oral hygiene guidance. The primary endpoint is the incidence and onset time of grade 3 oral mucositis. The secondary endpoints are the incidence and onset time of grade 2 oral mucositis, incidence and onset time of oral candidiasis, completion of radiation therapy and adverse events. Target accrual is 102 patients with a two-sided type I error rate of 5% and 80% power to detect an 80% risk reduction in the incidence of grade 3 oral mucositis. ETHICS AND DISSEMINATION: This study was approved by the Clinical Research Review Board of Nagasaki University (No. CRB20-009). All participants will be required to provide written informed consent. Findings will be disseminated through scientific and professional conferences and peer-reviewed journal publication. The datasets generated during the study will be available from the corresponding author on reasonable request. TRIAL REGISTRATION NUMBER: jRCTs071200013.

    2022年01月17日, BMJ open, 12 (1), e056781, 英語, 国際誌

    研究論文(学術雑誌)

  • Akiko Sakakibara, Takumi Hasegawa, Daisuke Takeda, Junya Kusumoto, Shunsuke Sakakibara, Masaya Akashi

    Schwannomas commonly occur in the head and neck region as acoustic neuromas. Facial nerve schwannomas are rare and usually occur in the temporal region. A 57-year-old woman presented with a mass at the right mandibular margin. Magnetic resonance imaging revealed a schwannoma located immediately caudal to the mental foramen. We were initially uncertain whether it arose from the trigeminal nerve or the facial nerve. Excision was performed under general anesthesia. The mass was encapsulated and easily detached from the surrounding tissue. The nerve of origin was identified proximal to the tumor. A facial nerve origin was confirmed as the muscles supplied by the marginal mandibular branch of the facial nerve moved on nerve stimulation. Nerve fibers were not found distal to the tumor, possibly because they had been cut during excision. We believe that this is the first report of a schwannoma arising from the peripheral facial nerve.

    2021年07月, Journal of surgical case reports, 2021 (7), rjab299, 英語, 国際誌

  • 膵頭十二指腸切除術における周術期口腔機能管理の術後合併症予防効果

    山口 泰平, 高島 裕之, 森田 麻希, 渋谷 恭之, 五月女 さき子, 林田 咲, 村田 真穂, 梅田 正博, 延原 浩, 長谷川 巧実, 明石 昌也, 兒島 由佳, 小西 尚晃, 中原 寛和, 山田 慎一, 栗田 浩, 森 和代, 於保 孝彦

    (一社)日本口腔ケア学会, 2020年09月, 日本口腔ケア学会雑誌, 14 (3), 114 - 114, 日本語

  • 周術期口腔ケアによる胃癌術後合併症予防効果に関する臨床的検討

    高島 裕之, 五月女 さき子, 林田 咲, 村田 真穂, 梅田 正博, 延原 浩, 長谷川 巧実, 明石 昌也, 上田 順宏, 下辻 寛子, 桐田 忠昭, 小西 尚晃, 中原 寛和, 山田 慎一, 栗田 浩, 山口 泰平, 森 和代, 渋谷 恭之

    (一社)日本口腔ケア学会, 2020年09月, 日本口腔ケア学会雑誌, 14 (3), 123 - 123, 日本語

  • 多施設後ろ向き試験による舌癌における手術断端近接症例の検討 JOOG study(RA2101)

    大鶴 光信, 長谷川 巧実, 山川 延宏, 大倉 正也, 山田 慎一, 平井 英治, 猪俣 徹, 齋藤 寛一, 三浦 桂一郎, 古川 浩平, 鳴瀬 智史, 柳本 惣市, 梅田 正博

    (一社)日本頭頸部癌学会, 2022年05月, 頭頸部癌, 48 (2), 216 - 216, 日本語

  • Nanae Yatagai, Takumi Hasegawa, Katsusuke Kyotani, Tomohiro Noda, Rika Amano, Izumi Saito, Satomi Arimoto, Daisuke Takeda, Yasumasa Kakei, Masaya Akashi

    INTRODUCTION: Scarring and pain are postoperative complications in patients after head and neck cancer treatment; however, there is no effective treatment. These complications are affected by local blood flow disorders, and it is well known that the transcutaneous application of carbon dioxide (CO2) improves local blood flow. Previously, we have shown that the transcutaneous application of carbon dioxide causes absorption of CO2 and increase the oxygen (O2) pressure in the treated tissue; it is expected that the application of CO2 may reduce scarring and pain caused by cancer treatment. We newly introduced the CO2 paste as a new CO2 application method, which does not need to use CO2 gas directly. In this study, we aimed to apply of CO2 paste to healthy people and to investigate its usefulness, safety and feasibility by analysing the increase in blood flow and frequency of adverse events. METHODS: We applied carbon dioxide paste to skin over the sternocleidomastoid and gastrocnemius muscles of eight healthy volunteers. The changes in blood flow before and after the CO2 paste application using dynamic MRI, and changes in the vital signs were evaluated. RESULTS: In the neck area and middle layer of the lower leg, the signal intensity (SI) significantly increased 60 seconds after application. In the surface layer of the lower leg, the SI was significantly increased 60 and 300 seconds after paste application. Although mild heat was noted after the paste application, no obvious adverse events occurred. CONCLUSION: We demonstrated the increase in SI by dynamic MRI at the site of the carbon dioxide paste application, which indicates the paste application is effective in improving the blood flow.

    2022年07月22日, Medicine, 101 (29), e29511, 英語, 国際誌

    研究論文(学術雑誌)

  • 井堂 信二郎, 李 進彰, 重田 崇至, 長谷川 巧実, 有馬 宏美, 古森 孝英

    The patient was a 63-year-old woman with a history of diabetes. At initial diagnosis, blood tests suggested the presence of severe infection because the while cell count was 20800/μland the C-reactive protein level was 35.6 mg/dl, but computed tomographic (CT) imaging showed no gas in the submandibular space. She received anti-inflammatory treatment after hospitalization, but the symptoms did not improve. We therefore repeated CT imaging and discovered gas in the tissue space around the submental region. Based on the diagnosis of cervical necrotizing fasciitis, we performed emergency surgery, curettage of the lesion, and open surgery. The preoperative plain chest X-ray films the showed no abnormal findings. On the following day after surgery, SpO2 fell to the range of 80 %. A plain chest X-ray film showed shadows over the entire right lung field. The left lung showed signs of pneumonia with diffuse shadows. Chest CT images revealed shadows and accumulations of pleural effusion in both lung fields. The patient was given a diagnosis of a lung injury due to acute respiratory distress syndrome (ARDS) complicated by a severe infection. She received an intravenous drip infusion of sivelestat sodium (product name: Elaspol ) at a dose of 200 mg/day for 7 days. Pneumonia started to improve on the day afterstarting treatment.
    Our findings suggest that patients with severe infection should receive systemic management, bearing in mind potential complications of ARDS.

    Japanese Society of Oral and Maxillofacial Surgeons, 2010年10月20日, 日本口腔外科学会雑誌, 56 (10), 581 - 585, 日本語

  • Shin-Ichi Yamada, Takumi Hasegawa, Nobuhiro Yamakawa, Masashi Tamura, Atsushi Takizawa, Yasumasa Kakei, Masaya Okura, Tomofumi Naruse, Mitsunobu Otsuru, Shin Rin, Michihiro Ueda, Tetsuro Yamashita, Tadaaki Kirita, Yoshihide Ota, Hiroshi Kurita

    OBJECTIVES: The purpose of this multicenter retrospective study was to investigate the demographic characteristics and treatment outcomes of patients with mucosal malignant melanoma (MM) of the oral cavity. MATERIALS AND METHODS: This was a multicenter study involving 8 Japanese universities. The medical records of 69 patients who were diagnosed with primary oral MM between January 2000 and December 2020 were retrospectively analyzed. Overall survival (OS) and prognostic factors for OS were analyzed statistically. RESULTS: There were 40 (58.0%) males and 29 (42.0%) females, and their mean (range) age was 69.8 ± 14.6 (22-96) years old. The most common primary site was the palate (30 patients, 43.5%). Stage IVA was the most common disease stage (36 patients, 52.2%). Radical therapy was performed in 55 patients (79.7%). The 2-year and 5-year OS rates of the 69 patients were 64.6% and 42.5%, respectively. The 2-year and 5-year OS rates of the stage III patients were 85.9% and 72.5%, respectively, and those of the stage IVA patients were 56.3% and 26.0%, respectively. The 1-year OS rate of the stage IVB/IVC patients was 26.7%. The 2-year and 5-year OS rates of the radical therapy group were 74.1% and 50.5%, respectively, whereas the 2-year OS rate of the non-radical therapy group was 26.0%. An advanced T classification was the only identified prognostic factor for OS (hazard ratio: 6.312, 95% confidence interval: 1.133-38.522, p < 0.05). CONCLUSIONS: Early detection and radical treatment are essential for improving the prognosis of oral MM patients. CLINICAL RELEVANCE: Early detection and adequate radical therapy leads to the better prognosis of oral MM patients.

    2022年08月03日, Clinical oral investigations, 英語, 国際誌

    研究論文(学術雑誌)

MISC

  • 口腔外科手術周術期における抗血栓療法患者に対するヘパリンブリッジの有効性に関する多施設共同後ろ向き観察研究

    後藤弘一, 山田慎一, 長谷川巧実, 吉村仁志, 五月女さき子, 冨原圭, 長谷川温, 菱田純代, 上田順宏, 傳田祐也, 岡本健二郎, 明石昌也, 近津大地, 野口誠, 太田嘉英, 藤田茂之, 藤田茂之, 渋谷恭之, 桐田忠昭, 梅田正博, 栗田浩

    2020年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 38th

  • 大腸癌術後SSIに対する周術期口腔ケアの予防効果に関する多施設共同研究

    延原浩, 五月女さき子, 林田咲, 梅田正博, 長谷川巧実, 明石昌也, 山田慎一, 栗田浩, 中原寛和, 上田順宏, 桐田忠昭, 中村知寿, 渋谷恭之, 山口泰平, 森和代

    2020年, 日本外科感染症学会雑誌(Web), 17 (5)

  • 「口腔がん治療における周術期口腔機能管理とは?」 口腔・中咽頭がん放射線治療時の口腔粘膜炎と口腔カンジダ症のリスク因子 多施設共同研究による326例の解析結果

    西井 美佳, 五月女 さき子, 長谷川 巧実, 柚鳥 宏和, 川北 晃子, 兒島 由佳, 船原 まどか, 梅田 正博, 明石 昌也, 古森 孝英

    口腔・中咽頭がん放射線治療患者326例の口腔粘膜炎と口腔カンジダ症について後ろ向きに検討し、以下の結果を得た。1.グレード3口腔粘膜炎は、326例中131例(41.7%)に生じた。2.グレード3口腔粘膜炎の発症リスク因子として、男性、中咽頭原発、シスプラチンやセツキシマブ併用、白血球低値・リンパ球低値・ヘモグロビン低値、経口摂取が挙げられた。3.口腔カンジダ症は、326例中101例(31.0%)に生じた。4.口腔カンジダ症発症のリスク因子として、中咽頭原発、白血球減少、グレード2以上の口腔粘膜炎が挙げられた。ステロイド軟膏はリスク因子ではなかった。(著者抄録)

    (一社)日本口腔腫瘍学会, 2019年09月, 日本口腔腫瘍学会誌, 31 (3), 111 - 116, 日本語

  • 口腔・中咽頭がん放射線治療時の口腔粘膜炎予防法について 歯科衛生士の立場からの提言

    西井 美佳, 長谷川 巧実, 澤田 麻衣子, 巽口 明香, 岩田 英治, 五月女 さき子, 兒島 由佳, 船原 まどか, 梅田 正博, 古森 孝英

    (一社)日本口腔ケア学会, 2019年04月, 日本口腔ケア学会雑誌, 13 (3), 189 - 189, 日本語

  • 抗凝固薬内服患者における下顎智歯抜去後の後出血発症に関する多施設共同後ろ向き観察研究

    高田 亮, 山田 慎一, 長谷川 巧実, 五月女 さき子, 吉村 仁志, 宮腰 昌明, 上田 順宏, 岡本 健二朗, 菱田 純代, 横関 麻里, 中原 寛和, 藤田 茂之, 古森 孝英, 佐野 和生, 北川 善政, 渋谷 恭之, 桐田 忠昭, 梅田 正博, 栗田 浩

    (一社)日本歯科薬物療法学会, 2019年03月, 歯科薬物療法, 38 (2), 176 - 176, 日本語

  • 抗凝固薬内服患者における下顎智歯抜去後の後出血発症に関する多施設共同後ろ向き観察研究

    高田 亮, 山田 慎一, 長谷川 巧実, 五月女 さき子, 吉村 仁志, 宮腰 昌明, 上田 順宏, 岡本 健二朗, 菱田 純代, 横関 麻里, 中原 寛和, 藤田 茂之, 古森 孝英, 佐野 和生, 北川 善政, 渋谷 恭之, 桐田 忠昭, 梅田 正博, 栗田 浩

    (一社)日本歯科薬物療法学会, 2019年03月, 歯科薬物療法, 38 (2), 176 - 176, 日本語

  • 当科におけるメトトレキサート関連リンパ増殖性疾患の3例

    大橋雄高, 筧康正, 松田彩, 榊原晶子, 長谷川巧実, 南川勉, 古森孝英

    2019年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 37th, 148, 日本語

  • 当科におけるUnusualな再発症例について

    筧康正, 南川勉, 松田彩, 榊原晶子, 長谷川巧実, 明石昌也, 古森孝英

    2019年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 37th, 122, 日本語

  • 炭酸ガスを使用した効率的な低酸素環境改善による口腔癌の新規治療法の開発と治療抵抗性の改善効果

    長谷川巧実, 武田大介, 齋藤泉, 岩田英治, 筧康正, 榊原晶子, 明石昌也, 南川勉, 古森孝英

    2019年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 37th, 120, 日本語

  • 再建を伴う口腔癌の周術期静脈血栓塞栓症について

    筧康正, 明石昌也, 長谷川巧実, 南川勉, 古森孝英

    2019年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 37th, 112, 日本語

  • 口腔癌におけるPET‐MRI~第二報~

    瓜生開人, 南川勉, 大橋雄高, 大橋雄高, 松田彩, 武田大介, 筧康正, 松井太輝, 榊原晶子, 長谷川巧実, 明石昌也, 古森孝英

    2019年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 37th, 156, 日本語

  • 口腔扁平上皮癌を有する高齢者に対するG8スクリーニングツールの臨床的意義

    箱山友祐, 箱山友祐, 山田慎一, 横関麻里, 田中宏和, 田中宏和, 長谷川巧実, 奥山紘平, 山川延宏, 大倉正也, 柳本惣市, 古森孝英, 桐田忠昭, 梅田正博, 栗田浩

    2019年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 37th

  • 「抗血栓療法患者の抜歯ガイドライン」改訂に向けて2015年度版の自己評価 抗凝固療法(ワルファリン投与)患者の抜歯後出血リスク因子について 多施設共同研究の結果から

    長谷川 巧実

    (一社)日本有病者歯科医療学会, 2018年12月, 有病者歯科医療, 27 (6), 451 - 451, 日本語

  • Masaya Akashi, Junya Kusumoto, Daisuke Takeda, Takashi Shigeta, Takumi Hasegawa, Takahide Komori

    PURPOSE: Few studies exist that focus on the details of perioperative antibiotic administration for surgery to treat medication-related osteonecrosis of the jaw (MRONJ). The regime and duration of perioperative antibiotics applied in published studies were reviewed to clarify appropriate perioperative antibiotic use in MRONJ surgery. METHODS: A literature search was conducted using the MEDLINE database via PubMed. RESULTS: The search resulted in 453 hits on PubMed. After reading the downloaded full-text articles, 17 articles met the inclusion and exclusion criteria. The most common perioperative antibiotic used for MRONJ surgery was a combination of penicillin-based antibiotics and β-lactamase inhibitor (52.9%), and the second most common regime was penicillin-based antibiotics with metronidazole (17.6%). The duration of administration was 2 weeks postoperatively in nine studies, whereas four studies applied long-term administration (2-6 weeks postoperatively). CONCLUSIONS: Oral and maxillofacial surgeons mostly prefer penicillin-based antibiotics plus β-lactamase inhibitor or metronidazole for MRONJ surgery. The duration of administration of these medications may be based on empirical experience.

    2018年12月, Oral and maxillofacial surgery, 22 (4), 369 - 378, 英語, 国際誌

    [査読有り]

  • 当科におけるインプラント埋入症例と喪失リスク因子に関する後ろ向き観察研究

    長谷川 巧実, 武田 大介, 齋藤 泉, 有本 智美, 筧 康正, 明石 昌也, 鈴木 泰明, 古森 孝英

    (公社)日本顎顔面インプラント学会, 2018年11月, Japanese Journal of Maxillo Facial Implants, 17 (3), 224 - 224, 日本語

  • 癌患者の口腔機能管理の基準に関する多施設共同後ろ向き観察研究

    山田 慎一, 五月女 さき子, 長谷川 巧実, 東條 格, 中原 寛和, 河上 真緒, 廣瀬 満理奈, 藤田 茂之, 古森 孝英, 桐田 忠昭, 渋谷 恭之, 梅田 正博, 栗田 浩

    (一社)日本癌治療学会, 2018年10月, 日本癌治療学会学術集会抄録集, 56回, P1 - 1, 英語

  • 医科歯科連携 がん手術時の周術期口腔機能管理の有効性に関する多施設共同研究

    五月女 さき子, 林田 咲, 川北 晃子, 岩田 英治, 長谷川 巧実, 古森 孝英, 山田 慎一, 栗田 浩, 宮本 大模, 渋谷 恭之, 河岡 有美, 兒島 由佳, 山口 泰平, 於保 孝彦, 中原 寛和, 延原 浩, 船原 まどか, 梅田 正博

    (NPO)日本口腔科学会, 2018年07月, 日本口腔科学会雑誌, 67 (2), 89 - 89, 日本語

  • 骨代謝学と口腔外科学のクロスオーバーからクロスイノベーションへ 薬剤関連顎骨壊死の治療と予防(口腔外科の立場から)

    梅田 正博, 林田 咲, 長谷川 巧実, 五月女 さき子

    (一社)日本骨代謝学会, 2018年07月, 日本骨代謝学会学術集会プログラム抄録集, 36回, 107 - 107, 日本語

  • 口腔癌術後に予定外に再度の全身麻酔による手術を要した症例の検討

    大橋 雄高, 筧 康正, 松田 彩, 松井 太輝, 榊原 晶子, 長谷川 巧実, 明石 昌也, 南川 勉, 古森 孝英

    (NPO)日本口腔科学会, 2018年07月, 日本口腔科学会雑誌, 67 (2), 110 - 110, 日本語

  • 医科歯科連携 抜歯と薬剤関連性顎骨壊死に関する多施設共同後ろ向き研究 注射BP製剤とデノスマブにおける抜歯前休薬の有無について

    長谷川 巧実, 上田 順宏, 近藤 英司, 岩田 英治, 林田 咲, 河岡 有美, 小林 正樹, 宮本 大模, 武田 侑也, 中原 寛和, 橘 進彰, 兒島 由佳, 五月女 さき子, 桐田 忠昭, 栗田 浩, 渋谷 恭之, 藤田 茂之, 古森 孝英

    (NPO)日本口腔科学会, 2018年07月, 日本口腔科学会雑誌, 67 (2), 89 - 89, 日本語

  • 頸部リンパ節転移陽性口腔扁平上皮癌の予後因子におけるlymph node ratioの有用性に関する検討

    筧 康正, 南川 勉, 白井 達也, 大橋 雄高, 松田 彩, 松井 太輝, 榊原 晶子, 長谷川 巧実, 明石 昌也, 古森 孝英

    (NPO)日本口腔科学会, 2018年07月, 日本口腔科学会雑誌, 67 (2), 103 - 103, 日本語

  • 当科における口腔癌への緩和照射に関する臨床的検討

    松田 彩, 南川 勉, 白井 達也, 筧 康正, 松井 太輝, 長谷川 巧実, 榊原 晶子, 明石 昌也, 古森 孝英

    (NPO)日本口腔科学会, 2018年07月, 日本口腔科学会雑誌, 67 (2), 112 - 112, 日本語

  • 術後に気道閉塞を生じた口腔癌患者の3例

    香西 慎一, 松井 太輝, 筧 康正, 松田 彩, 明石 昌也, 長谷川 巧実, 南川 勉, 古森 孝英

    (NPO)日本口腔科学会, 2018年07月, 日本口腔科学会雑誌, 67 (2), 113 - 113, 日本語

  • 頸部郭清を伴う口腔癌術後合併症に関する臨床的検討

    八谷 奈苗, 長谷川 巧実, 武田 大介, 筧 康正, 松井 太輝, 明石 昌也, 南川 勉, 古土井 春吾, 古森 孝英

    (NPO)日本口腔科学会, 2018年07月, 日本口腔科学会雑誌, 67 (2), 117 - 117, 日本語

  • 口腔癌原発巣手術における術中迅速診断の臨床的検討

    白井 達也, 松井 太輝, 筧 康正, 大橋 雄高, 松田 彩, 長谷川 巧実, 明石 昌也, 南川 勉, 古森 孝英

    (NPO)日本口腔科学会, 2018年07月, 日本口腔科学会雑誌, 67 (2), 119 - 119, 日本語

  • 膠原病を有する口腔癌症例の臨床的検討

    廣田 純也, 南川 勉, 松田 彩, 松井 太輝, 筧 康正, 榊原 晶子, 長谷川 巧実, 明石 昌也, 古森 孝英

    (NPO)日本口腔科学会, 2018年07月, 日本口腔科学会雑誌, 67 (2), 121 - 121, 日本語

  • 下顎智歯抜歯後の術後出血に関するリスク因子についての検討

    廣田 純也, 長谷川 巧実, 西條 翔, 大山 剛平, 武田 大介, 明石 昌也, 古森 孝英

    (NPO)日本口腔科学会, 2018年07月, 日本口腔科学会雑誌, 67 (2), 131 - 132, 日本語

  • がん治療中の口腔有害事象発症リスクに関する後ろ向き観察研究

    三谷 泉, 長谷川 巧実, 難波 渚, 西井 美佳, 明石 昌也, 古土井 春吾, 古森 孝英

    (NPO)日本口腔科学会, 2018年07月, 日本口腔科学会雑誌, 67 (2), 171 - 172, 日本語

  • 高齢者疾患と歯科治療 注意すべき薬とその対応法

    長谷川 巧実

    (一社)兵庫県歯科医師会, 2018年05月, 歯界月報, (802), 84 - 84, 日本語

  • 金属アレルギーを伴う骨格性下顎前突患者に対し外科的矯正治療を行った1例

    塩屋園 敦, 立石 千鶴, 長谷川 巧実, 木本 明, 鈴木 泰明, 古土井 春吾, 古森 孝英, 神戸大学医学部附属病院歯科口腔外科矯正歯科診療班

    (NPO)日本顎変形症学会, 2018年05月, 日本顎変形症学会雑誌, 28 (2), 181 - 181, 日本語

  • がん口腔管理ガイドライン 癌患者の口腔機能管理の基準に関する多施設共同後ろ向き観察研究

    山田 慎一, 五月女 さき子, 長谷川 巧実, 東條 格, 中原 寛和, 河上 真緒, 宮本 大模, 藤田 茂之, 古森 孝英, 桐田 忠昭, 渋谷 恭之, 梅田 正博, 栗田 浩

    (一社)日本口腔ケア学会, 2018年04月, 日本口腔ケア学会雑誌, 12 (3), 134 - 134, 日本語

  • 肺癌術後肺炎予防における周術期口腔機能管理の有用性 傾向スコアマッチング法を用いた解析

    岩田 英治, 長谷川 巧実, 山田 慎一, 川下 由美子, 吉松 昌子, 宮本 大模, 中原 寛和, 渋谷 恭之, 栗田 浩, 古森 孝英

    (一社)日本口腔ケア学会, 2018年04月, 日本口腔ケア学会雑誌, 12 (3), 196 - 196, 日本語

  • 抜歯における下唇知覚鈍麻と上顎洞穿孔のリスクとその対応

    長谷川 巧実

    (一社)兵庫県歯科医師会, 2018年04月, 歯界月報, (801), 52 - 60, 日本語

    記事・総説・解説・論説等(学術雑誌)

  • 頸部郭清を伴う口腔癌術後合併症に関する臨床的検討

    八谷奈苗, 長谷川巧実, 武田大介, 筧康正, 松井太輝, 明石昌也, 南川勉, 古土井春吾, 古森孝英

    2018年, 日本口腔科学会雑誌(Web), 67 (2), 117(J‐STAGE), 日本語

  • 頸部リンパ節転移陽性口腔扁平上皮癌の予後因子におけるlymph node ratioの有用性に関する検討

    筧康正, 南川勉, 白井達也, 大橋雄高, 大橋雄高, 松田彩, 松井太輝, 榊原晶子, 長谷川巧実, 明石昌也, 古森孝英

    2018年, 日本口腔科学会雑誌(Web), 67 (2), 103(J‐STAGE), 日本語

  • 膠原病を有する口腔癌症例の臨床的検討

    廣田純也, 南川勉, 松田彩, 松井太輝, 筧康正, 榊原晶子, 長谷川巧実, 明石昌也, 古森孝英

    2018年, 日本口腔科学会雑誌(Web), 67 (2), 121(J‐STAGE), 日本語

  • 放射線性下顎骨壊死の診断におけるfollow up PET‐CTの有用性

    鰐渕聡, 明石昌也, 平岡佑二郎, 武田大介, 筧康正, 松井太輝, 長谷川巧実, 南川勉, 古土井春吾, 古森孝英

    2018年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 36th, 161, 日本語

  • 皮弁再建後の再発舌癌に対して救済手術を施行した2例

    大橋雄高, 松井太輝, 筧康正, 正井友里子, 松田彩, 榊原晶子, 長谷川巧実, 明石昌也, 南川勉, 古森孝英

    2018年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 36th, 181, 日本語

  • 当科における口腔癌への緩和照射に関する臨床的検討

    松田彩, 南川勉, 白井達也, 筧康正, 松井太輝, 長谷川巧実, 榊原晶子, 明石昌也, 古森孝英

    2018年, 日本口腔科学会雑誌(Web), 67 (2), 112(J‐STAGE), 日本語

  • 超音波断層法による口腔癌頸部リンパ節転移の検討

    筧康正, 南川勉, 正井友里子, 松田彩, 松井太輝, 榊原晶子, 長谷川巧実, 明石昌也, 重田崇至, 古森孝英

    2018年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 36th, 160, 日本語

  • 舌扁平上皮癌の原発巣再発例の検討

    松井太輝, 南川勉, 大橋雄高, 正井友里子, 松田彩, 筧康正, 長谷川巧実, 明石昌也, 古森孝英

    2018年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 36th, 164, 日本語

  • 術後に気道閉塞を生じた口腔癌患者の3例

    香西慎一, 松井太輝, 筧康正, 松田彩, 明石昌也, 長谷川巧実, 南川勉, 古森孝英

    2018年, 日本口腔科学会雑誌(Web), 67 (2), 113(J‐STAGE), 日本語

  • 口腔癌術後病理minor risk症例の臨床的検討

    松田彩, 松井太輝, 正井友里子, 筧康正, 長谷川巧実, 榊原晶子, 明石昌也, 南川勉, 古森孝英

    2018年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 36th, 151, 日本語

  • 口腔癌術後に予定外に再度の全身麻酔による手術を要した症例の検討

    大橋雄高, 筧康正, 松田彩, 松井太輝, 榊原晶子, 長谷川巧実, 明石昌也, 南川勉, 古森孝英

    2018年, 日本口腔科学会雑誌(Web), 67 (2), 110(J‐STAGE), 日本語

  • 口腔癌再建術後Recipient‐site infectionの定義に関する文献レビュー

    明石昌也, 筧康正, 武田大介, 松井太輝, 榊原晶子, 長谷川巧実, 南川勉, 橋川和信, 古森孝英

    2018年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 36th, 149, 日本語

  • 口腔癌原発巣手術における術中迅速診断の臨床的検討

    白井達也, 松井太輝, 筧康正, 大橋雄高, 大橋雄高, 松田彩, 長谷川巧実, 明石昌也, 南川勉, 古森孝英

    2018年, 日本口腔科学会雑誌(Web), 67 (2), 119(J‐STAGE), 日本語

  • がん手術時の周術期口腔機能管理の有効性に関する多施設共同研究

    五月女さき子, 林田咲, 川北晃子, 岩田英治, 長谷川巧実, 古森孝英, 山田慎一, 栗田浩, 宮本大模, 渋谷恭之, 河岡有美, 兒島由佳, 山口泰平, 於保孝彦, 中原寛和, 延原浩, 船原まどか, 梅田正博

    2018年, 日本口腔科学会雑誌(Web), 67 (2)

  • 抜歯と薬剤関連性顎骨壊死に関する多施設共同後ろ向き研究~注射BP製剤とデノスマブにおける抜歯前休薬の有無について~

    長谷川巧実, 上田順宏, 近藤英司, 岩田英治, 岩田英治, 林田咲, 河岡有美, 小林正樹, 宮本大模, 武田侑也, 中原寛和, 橘進彰, 兒島由佳, 五月女さき子, 桐田忠昭, 栗田浩, 渋谷恭之, 藤田茂之, 古森孝英

    2018年, 日本口腔科学会雑誌(Web), 67 (2)

  • 口腔がん手術の適応を考える 頸部リンパ節の状態から考えた手術の適応と補助療法

    長谷川 巧実, 南川 勉, 古森 孝英

    根治手術を行った口腔扁平上皮癌のうち病理組織学的に被膜外浸潤陽性(Extranodal Extension(ENE))であった患者116例を対象とし、その術後治療別の予後と、術後CCRT群の有害事象について後ろ向きに検討した。術後CCRT群において、放射線照射60Gy以上、CDDP総投与量200mg/m2以上を完遂した症例は39例(84.8%)であった。3年累積局所頸部制御率は、外科処置単独群で35.4%、術後RT群で53.6%、術後CCRT群で68.9%であった。また、3年累積生存率は、外科処置単独群で25.1%、術後RT群で59.2%、術後CCRT群で43.8%であった。また、ENE+およびpN1であった34例では、3年累積局所頸部制御率は、外科処置単独群で53.3%、術後RT群で72.9%、術後CCRT群で71.0%であった。また、3年累積生存率は、外科処置単独群で55.6%、術後RT群で75.0%、術後CCRT群で70.3%であった。本研究結果から進行口腔癌の術後再発高リスク症例に対する高用量CDDPの術後RTへの上乗せ効果は局所頸部に限定的である可能性が考えられた。また、頸部リンパ節の転移様相をふまえ、その頸部郭清術の適応、術式選択、術後補助療法について考察した。(著者抄録)

    (一社)日本口腔腫瘍学会, 2017年12月, 日本口腔腫瘍学会誌, 29 (4), 198 - 205, 日本語

    記事・総説・解説・論説等(学術雑誌)

  • 移植腓骨へ埋入したインプラント体の周囲炎に対し炭酸ガスレーザーを適用した1例

    山下 淳也, 鈴木 泰明, 筧 康正, 木本 明, 長谷川 巧実, 明石 昌也, 松本 耕佑, 古森 孝英

    (公社)日本顎顔面インプラント学会, 2017年11月, Japanese Journal of Maxillo Facial Implants, 16 (3), 233 - 233, 日本語

  • 口腔ケアの食道癌術後肺炎予防効果に関する多施設共同研究:傾向スコア法による解析

    五月女さき子, 柳本惣市, 山田慎一, 栗田浩, 山内千佳, 渋谷恭之, 中原寛和, 長谷川巧実, 古森孝英, 兒島由佳, 青木久美子, 桐田忠昭, 於保孝彦, 梅田正博

    (一社)日本癌治療学会, 2017年10月, 日本癌治療学会学術集会(Web), 55th, ROMBUNNO.PS‐2 (WEB ONLY) - 2, 日本語

  • 当科における予防的頸部郭清術に関する後ろ向き検討

    松田 彩, 筧 康正, 正井 友里子, 米澤 奈津季, 榊原 晶子, 長谷川 巧実, 明石 昌也, 南川 勉, 古森 孝英

    (NPO)日本口腔科学会, 2017年07月, 日本口腔科学会雑誌, 66 (2), 113 - 113, 日本語

  • 口腔扁平上皮癌における術後早期(1年以内)の予後不良例に関する臨床的検討

    正井 友里子, 南川 勉, 松田 彩, 米澤 奈津季, 筧 康正, 榊原 晶子, 長谷川 巧実, 明石 昌也, 古森 孝英

    (NPO)日本口腔科学会, 2017年07月, 日本口腔科学会雑誌, 66 (2), 114 - 114, 日本語

  • 口腔癌手術における嚥下改善手術に関する臨床的検討

    筧 康正, 南川 勉, 正井 友里子, 松田 彩, 米澤 奈津季, 榊原 晶子, 長谷川 巧実, 明石 昌也, 古森 孝英

    (NPO)日本口腔科学会, 2017年07月, 日本口腔科学会雑誌, 66 (2), 114 - 114, 日本語

  • 食道がん術後肺炎に対する口腔ケアの予防効果~口腔ケア学会共同研究委員会による多施設共同研究の提案~

    五月女さき子, 栗田浩, 植野高章, 渋谷恭之, 大部一成, 山口泰平, 長谷川巧実, 冨原圭, 青木久美子, 池上由美子

    (一社)日本口腔ケア学会, 2017年04月22日, 日本口腔ケア学会雑誌, 11 (3), 122 - 122, 日本語

  • 頭頸部癌化学放射線治療患者における口腔内細菌数と口腔粘膜水分量の解析

    西井 美佳, 筧 康正, 難波 渚, 澤田 麻衣子, 岩田 英治, 長谷川 巧実, 明石 昌也, 古土井 春吾, 古森 孝英

    (一社)日本口腔ケア学会, 2017年04月, 日本口腔ケア学会雑誌, 11 (3), 121 - 121, 日本語

  • 肺癌術後肺合併症と周術期口腔機能管理の有用性

    岩田 英治, 長谷川 巧実, 西井 美佳, 明石 昌也, 古森 孝英

    (一社)日本口腔ケア学会, 2017年04月, 日本口腔ケア学会雑誌, 11 (3), 170 - 170, 日本語

  • 当科における予防的頸部郭清術に関する後ろ向き検討

    松田彩, 筧康正, 正井友里子, 米澤奈津季, 榊原晶子, 長谷川巧実, 明石昌也, 南川勉, 古森孝英

    2017年, 日本口腔科学会学術集会プログラム・抄録集, 71st, 181, 日本語

  • 口腔扁平上皮癌における術後早期(1年以内)の予後不良例に関する臨床的検討

    正井友里子, 南川勉, 松田彩, 米澤奈津季, 筧康正, 榊原晶子, 長谷川巧実, 明石昌也, 古森孝英

    2017年, 日本口腔科学会学術集会プログラム・抄録集, 71st, 183, 日本語

  • 口腔癌手術における嚥下改善手術に関する臨床的検討

    筧康正, 南川勉, 正井友里子, 松田彩, 米澤奈津季, 榊原晶子, 長谷川巧実, 明石昌也, 古森孝英

    2017年, 日本口腔科学会学術集会プログラム・抄録集, 71st, 183, 日本語

  • Risk factors associated with oroantral perforation during surgical removal of maxillary third molar teeth.

    Takumi Hasegawa, Akira Tachibana, Daisuke Takeda, Eiji Iwata, Satomi Arimoto, Akiko Sakakibara, Masaya Akashi, Takahide Komori

    PURPOSE: The relationship between radiographic findings and the occurrence of oroantral perforation is controversial. Few studies have quantitatively analyzed the risk factors contributing to oroantral perforation, and no study has reported multivariate analysis of the relationship(s) between these various factors. This retrospective study aims to fill this void. METHODS: Various risk factors for oroantral perforation during maxillary third molar extraction were investigated by univariate and multivariate analysis. The proximity of the roots to the maxillary sinus floor (root-sinus [RS] classification) was assessed using panoramic radiography and classified as types 1-5. The relationship between the maxillary second and third molars was classified according to a modified version of the Archer classification. The relative depth of the maxillary third molar in the bone was classified as class A-C, and its angulation relative to the long axis of the second molar was also recorded. RESULTS: Performance of an incision (OR 5.16), mesioangular tooth angulation (OR 6.05), and type 3 RS classification (i.e., significant superimposition of the roots of all posterior maxillary teeth with the sinus floor; OR 10.18) were all identified as risk factors with significant association to an outcome of oroantral perforation. CONCLUSION: To our knowledge, this is the first multivariate analysis of the risk factors for oroantral perforation during surgical extraction of the maxillary third molar. This RS classification may offer a new predictive parameter for estimating the risk of oroantral perforation.

    2016年12月, Oral and maxillofacial surgery, 20 (4), 369 - 375, 英語, 国際誌

  • 内視鏡支援下で上顎洞迷入インプラントの摘出後に骨造成術を行った1例

    山下 淳也, 鈴木 泰明, 筧 康正, 木本 明, 長谷川 巧実, 明石 昌也, 古森 孝英

    (公社)日本顎顔面インプラント学会, 2016年11月, Japanese Journal of Maxillo Facial Implants, 15 (3), 207 - 207, 日本語

  • 当科におけるFibro-osseous lesionsの臨床的検討

    松尾 健司, 明石 昌也, 筧 康正, 松本 耕祐, 長谷川 巧実, 南川 勉, 古土井 春吾, 橘 進彰, 古森 孝英

    (NPO)日本口腔科学会, 2016年07月, 日本口腔科学会雑誌, 65 (2), 127 - 128, 日本語

  • 遺伝子解析により確定診断を得た頬粘膜MALTリンパ腫の1例

    筧 康正, 明石 昌也, 木本 明, 長谷川 巧実, 南川 勉, 古森 孝英

    (NPO)日本口腔科学会, 2016年07月, 日本口腔科学会雑誌, 65 (2), 214 - 214, 日本語

  • 食道がん術後肺炎予防に対する周術期口腔機能管理の有効性に関する多施設共同後ろ向き研究

    五月女さき子, 柳本惣市, 梅田正博, 長谷川巧実, 古森孝英, 山田慎一, 栗田浩, 渋谷恭之, 山内千佳, 兒島由佳

    2016年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 34th, 163, 日本語

  • 当科におけるFibro‐osseous lesionsの臨床的検討

    松尾健司, 明石昌也, 筧康正, 松本耕祐, 長谷川巧実, 南川勉, 古土井春吾, 橘進彰, 古森孝英

    2016年, 日本口腔科学会学術集会プログラム・抄録集, 70th, 159, 日本語

  • 術前18F‐FDG PET/CT撮影での口腔癌原発巣における定量評価の有用性

    米澤奈津季, 南川勉, 北島一宏, 高橋佑輔, 筧康正, 榊原晶子, 長谷川巧実, 明石昌也, 古森孝英

    2016年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 34th, 231, 日本語

  • 口腔扁平上皮癌被膜外浸潤症例の臨床病理学的検討

    筧康正, 南川勉, 寺岡駿, 米澤奈津季, 高橋佑輔, 長谷川巧実, 明石昌也, 古森孝英

    2016年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 34th, 234, 日本語

  • 口腔扁平上皮癌患者の遠位レベル(Level4,5)への頸部リンパ節転移が予後に与える影響

    定兼啓倫, 長谷川巧実, 渋谷恭之, 渋谷恭之, 米澤奈津季, 武田大介, 高橋佑輔, 筧康正, 明石昌也, 南川勉, 古森孝英

    2016年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 34th, 221, 日本語

  • 局所的炭酸ガス投与による皮弁壊死抑制効果

    齊藤泉, 長谷川巧実, 武田大介, 岩田英治, 有本智美, 筧康正, 高橋佑輔, 榊原晶子, 明石昌也, 南川勉, 古森孝英

    2016年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 34th, 208, 日本語

  • 遺伝子解析により確定診断を得た頬粘膜MALTリンパ腫の1例

    筧康正, 明石昌也, 木本明, 長谷川巧実, 南川勉, 古森孝英

    2016年, 日本口腔科学会学術集会プログラム・抄録集, 70th, 286, 日本語

  • 移植腓骨と下顎骨の癒合における骨膜温存の重要性

    明石昌也, 筧康正, 榊原晶子, 長谷川巧実, 南川勉, 橋川和信, 古森孝英

    2016年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 34th, 208, 日本語

  • 食道がん術後肺炎予防に対する周術期口腔機能管理の有効性 -多施設共同後ろ向き研究による検証-

    五月女さき子, 五月女さき子, 船原まどか, 船原まどか, 於保孝彦, 山田慎一, 山田慎一, 栗田浩, 栗田浩, 山内千佳, 山内千佳, 渋谷恭之, 渋谷恭之, 兒島由佳, 兒島由佳, 長谷川巧実, 長谷川巧実, 古森孝英, 古森孝英, 梅田正博, 梅田正博

    2016年, 日本口腔科学会雑誌(Web), 65 (4)

  • 【全身疾患と抜歯-最新の知識による適切な対応-】 全身疾患を有する患者の抜歯の際に注意すべき基本的事項

    古森孝英, 明石昌也, 鈴木泰明, 榊原晶子, 木本明, 南川勉, 長谷川巧実, 古土井春吾

    (株)第一歯科出版, 2015年01月, 歯科医療, 29 (1号), 4 - 10, 日本語

    [招待有り]

    記事・総説・解説・論説等(学術雑誌)

  • 【全身疾患と抜歯-最新の知識による適切な対応-】 抗凝固薬・抗血小板薬投与患者の抜歯

    長谷川巧実, 古森孝英

    2015年01月, 歯科医療, 29 (1号), 45 - 52, 日本語

    [招待有り]

    記事・総説・解説・論説等(商業誌、新聞、ウェブメディア)

  • 口腔癌術後再発ハイリスク因子を規定する被膜外浸潤の進展度分類

    大谷昇平, 山田慎一, 柳本惣市, 長谷川巧実, 宮腰昌明, 大賀則孝, 鎌田孝広, 古森孝英, 北川善政, 栗田浩, 朝比奈泉, 梅田正博

    2015年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 33rd, 245, 日本語

  • 当科における頸部郭清術術後の頸部ドレーンに関する臨床的検討

    齊藤泉, 長谷川巧実, 米澤奈津季, 武田大介, 高橋佑輔, 筧康正, 松井太輝, 榊原晶子, 明石昌也, 南川勉, 古森孝英

    2015年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 33rd, 295, 日本語

  • 当科における放射線性顎骨壊死に関する臨床的検討

    鰐渕聡, 明石昌也, 筧康正, 榊原晶子, 長谷川巧実, 南川勉, 古森孝英

    2015年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 33rd, 237, 日本語

  • 当科における口腔扁平上皮癌遠隔転移例の臨床的検討とリスク因子について

    棚倉万紀子, 長谷川巧実, 米澤奈津季, 武田大介, 高橋佑輔, 筧康正, 松井太輝, 榊原晶子, 明石昌也, 南川勉, 古森孝英

    2015年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 33rd, 301, 日本語

  • 口腔癌原発巣におけるDual‐time‐point FDG PETの有用性に関する検討

    米澤奈津季, 南川勉, 高橋佑輔, 筧康正, 松井太輝, 榊原晶子, 長谷川巧実, 明石昌也, 古森孝英

    2015年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 33rd, 188, 日本語

  • 口腔癌cN1症例に対する頸部郭清術の郭清範囲についての検討

    筧康正, 南川勉, 高橋佑輔, 松井太輝, 長谷川巧実, 明石昌也, 重田崇至, 古土井春吾, 渋谷恭之, 古森孝英

    2014年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 32nd, 172, 日本語

  • 40歳未満に発生した舌扁平上皮癌21例の検討

    高橋佑輔, 南川勉, 長谷川巧実, 米澤奈津季, 筧康正, 松井太輝, 榊原晶子, 重田崇至, 渋谷恭之, 古森孝英

    2014年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 32nd, 219, 日本語

  • ビスホスホネート関連顎骨壊死(BRONJ)に対する新規治療法の開発

    古森 孝英, 長谷川 巧実

    2013年, 大和証券ヘルス財団研究業績集, 36, 104 - 107, 日本語

    記事・総説・解説・論説等(その他)

  • 村田 真穂, 梅田 正博, 竹内 純一郎, 鈴木 泰明, 渋谷 恭之, 重田 崇至, 長谷川 巧実, 李 進彰, 小林 正樹, 古森 孝英

    軽度〜中程度の口腔粘膜欠損に対してポリグリコール酸シート(ネオベール)とフィブリン糊スプレー(ボルヒール)を使用し、その有用性を検討した。本材は柔軟性に富み、縫合の必要がないため短時間で貼付可能で、強固に創部と接着する。対象は舌や頬粘膜等、悪性腫瘍や白板症等の94症例(107部位、平均年齢64歳)で、切除術後のraw surfaceに本材を貼付した。その結果、創部との接着も良好で、疼痛緩和作用、感染予防作用を有すると考えられた。瘢痕拘縮もほとんどが軽度以下であった。また13部位で1週間以内の早期にネオベールが脱落した。ほとんどが初期の症例で、比較的小範囲の切除であったため術当日から経口摂食を開始した例であった。切除範囲の大小にかかわらず術後2日間は経管栄養を原則としたところ、以後早期脱落例はほとんど認めなくなった。

    (NPO)日本口腔科学会, 2011年07月, 日本口腔科学会雑誌, 60 (3), 232 - 239, 日本語

  • 骨折血腫細胞の多分化能についての検討と低出力超音波パルス(LIPUS)による効果について

    長谷川 巧実, 三輪 雅彦, 酒井 良忠, 新倉 隆宏, 大江 啓介, 岩倉 崇, 康 暁博, 澁谷 恭之, 黒坂 昌弘, 古森 孝英

    (公社)日本顎顔面インプラント学会, 2008年11月, Japanese Journal of Maxillo Facial Implants, 7 (2), 171 - 171, 日本語

  • ヒト新鮮骨折において、低出力超音波パルス(LIPUS)は骨折血腫細胞の骨分化を促進する

    岩倉 崇, 長谷川 巧実, 三輪 雅彦, 新倉 隆宏, 酒井 良忠, 大江 啓介, 李 相亮, 黒坂 昌弘

    (公社)日本整形外科学会, 2008年08月, 日本整形外科学会雑誌, 82 (8), S1195 - S1195, 日本語

  • ヒトの骨折治癒過程に携わる骨折血腫細胞には骨形成蛋白が発現している

    新倉 隆宏, 三輪 雅彦, 酒井 良忠, 大江 啓介, 岩倉 崇, 長谷川 巧実, 黒坂 昌弘

    (公社)日本整形外科学会, 2008年08月, 日本整形外科学会雑誌, 82 (8), S1259 - S1259, 日本語

  • β-リン酸三カルシウム(β-TCP)内への骨髄幹細胞(BMSC)導入方法と骨形成能の検討

    長谷川 巧実, 澁谷 恭之, 三輪 雅彦, 酒井 良忠, 新倉 隆宏, 大江 啓介, 岩倉 崇, 黒坂 昌弘, 古森 孝英

    (公社)日本口腔インプラント学会, 2008年03月, 日本口腔インプラント学会誌, 21 (1), 199 - 199, 日本語

  • 抗凝固薬内服患者における下顎智歯抜去後の後出血発症に関する多施設共同後ろ向き観察研究

    高田 亮, 山田 慎一, 長谷川 巧実, 五月女 さき子, 吉村 仁志, 宮腰 昌明, 上田 順宏, 岡本 健二朗, 菱田 純代, 横関 麻里, 中原 寛和, 藤田 茂之, 古森 孝英, 佐野 和生, 北川 善政, 渋谷 恭之, 桐田 忠昭, 梅田 正博, 栗田 浩

    (一社)日本有病者歯科医療学会, 2019年12月, 有病者歯科医療, 28 (6), 471 - 471, 日本語

  • 多施設後ろ向き試験による舌癌における手術断端近接症例の検討-Japan Oral Oncology Group(JOOG) study-

    大鶴光信, 長谷川巧実, 明石昌也, 山川延宏, 桐田忠昭, 大倉正也, 大倉正也, 山田慎一, 栗田浩, 平井英治, 山本晃三, 猪俣徹, 里見貴史, 齋藤寛一, 野村武史, 古川浩平, 鳴瀬智史, 柳本惣市, 梅田正博

    2022年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 40th

  • T1-2N0M0舌癌に予防郭清を行うことの是非に関する多施設共同研究(JOOG RA1403)

    大鶴 光信, 太田 嘉英, 梅田 正博, 柳本 惣市, 栗田 浩, 鎌田 孝広, 桐田 忠昭, 山川 延宏, 上田 倫弘, 山下 徹郎, 大倉 正也, 相川 友直, 大廣 洋一, 栗林 和代, 山下 善弘, 長井 健太郎, 野口 一馬, 岸本 裕充, 長谷川 巧実, 古森 孝英, 傳田 祐也, 内藤 博之, 柴原 孝彦, 野口 忠秀, 唐木田 一成

    (一社)日本頭頸部癌学会, 2016年05月, 頭頸部癌, 42 (2), 170 - 170, 日本語

書籍等出版物

  • 周術期等口腔機能管理の実際がよくわかる本.人工関節手術と口腔管理.

    長谷川巧実

    クインテッセンス株式会社., 2020年

  • 日常の口腔外科 改訂版 スマートな病診連携のために / 5画像検査の読影

    長谷川巧実, 藤岡学, 古森孝英

    その他, 永末書店, 2018年, 日本語

    学術書

  • Oral and Craniofacial Diseases and Disorders / Capter 2: Complications Following Radiation Therapy for Head and Neck Malignancy

    AkashiM, KomoriT, MinamikawaT, HasegawaT, NishiiM, HashikawaK, SeddikMH, SasakiR

    その他, Oxford University Press, 2018年, 英語

    学術書

  • Clinical Questionでわかるエビデンスに基づいた周術期口腔機能管理 / CHAPTER-4 周術期口腔機能管理に関するClinical Question Q16 骨吸収抑制薬投与患者の抜歯時に休薬は必要でしょうか?

    長谷川巧実

    その他, 医歯薬出版, 2018年, 日本語

    学術書

  • 全身疾患を有する患者の抜歯の際に注意すべき基本的事項 / 【全身疾患と抜歯-最新の知識による適切な対応-】

    古森孝英, 明石昌也, 鈴木泰明, 榊原晶子, 木本明, 南川勉, 長谷川巧実, 古土井春吾

    その他, 歯科医療, 2015年01月, 日本語

    学術書

  • 抗凝固薬・抗血小板薬投与患者の抜歯 / 【全身疾患と抜歯-最新の知識による適切な対応-】

    長谷川巧実, 古森孝英

    その他, -, 2015年01月, 日本語

    学術書

  • 新こんな患者さんが歯科に来たときは?全身疾患・口腔外科疾患に対する診療マニュアル / 抗血小板薬服用患者への対応

    長谷川巧実, 浅井雅敏, 白神翔, 梅田正博

    その他, 第一歯科出版, 2014年, 日本語

    一般書・啓蒙書

  • 新こんな患者さんが歯科に来たときは?全身疾患・口腔外科疾患に対する診療マニュアル / 抗凝固薬服用患者への対応

    長谷川巧実, 黄文蘇, 井川恵理, 梅田正博

    その他, 第一歯科出版, 2014年, 日本語

    一般書・啓蒙書

  • 新こんな患者さんが歯科に来たときは?全身疾患・口腔外科疾患に対する診療マニュアル / 血小板減少患者への対応

    長谷川巧実, 竹内佑香, 梅田正博

    その他, 第一歯科出版, 2014年, 日本語

    一般書・啓蒙書

講演・口頭発表等

  • The observational study of the risk factors associate with implant failure in our institution.

    Hasegawa T, Takeda D, Arimoto S, Kakei Y, Kimoto A, Akashi M

    The 4th Asia Pacific Region Congress of the International Association for Dental Research, 2019年11月28日

  • A multi-center retrospective study of mandibular fractures: Do occlusal support and the mandibular third molar affect mandibular condylar fractures?

    Takumi Hasegawa, Daisuke Takeda, Satomi Arimoto, Yasumasa Kakei, Masaya Akashi, Takahide Komori

    6th Asian Academy congress for TMJ, 2019年06月27日

  • A retrospective study of risk factors associated with distant metastasis in patients with oral squamous cell carcinoma

    Takumi Hasegawa, Daisuke Takeda, Yasumasa Kakei, Akiko Sakakibara, Masaya Akashi, Tsutomu Minamikawa, Takahide Komori

    6th Asian Society of Head & Neck Oncology, 2019年03月28日

  • 炭酸ガスを使用した効率的な低酸素環境改善による口腔癌の新規治療法の開発と治療抵抗性の改善効果

    長谷川巧実、武田大介、斉藤 泉、岩田英治、筧康正、榊原晶子、明石昌也、南川勉、古森孝英

    第37回日本口腔腫瘍学会総会, 2019年01月24日

    [招待有り]

  • 口腔癌頸部リンパ節転移の様相と術後補助療法に関する多施設共同研究

    長谷川巧実、柳本惣市、大鶴光信、大倉正也、山川延宏、山田慎一、古森孝英

    第37回日本口腔腫瘍学会総会, 2019年01月24日

    [招待有り]

  • 抜歯と薬剤関連性顎骨壊死に関する多施設共同後ろ向き研究 ~注射BP製剤とデノスマブにおける抜歯前休薬の有無について~

    長谷川巧実、上田順宏、近藤英司岩田英治林田 咲、河岡有美、小林正樹、宮本大模、武田侑也、中原寛和、橘 進彰、兒島由佳、五月女さき子、桐田忠昭、栗田 浩、渋谷恭之、藤田茂之、古森孝英

    第72回日本口腔科学会学術集会, 2018年05月12日

  • 下顎智歯抜歯後の下唇知覚鈍麻と術前のパノラマX線および多断面再構成CT画像所見との関係

    長谷川巧実、明石昌也、橘 進彰、古土井春吾、古森孝英

    第22回口腔顔面神経機能大会, 2018年03月

  • 下顎骨壊死における下歯槽神経障害の臨床病理学的検討

    平岡佑二郎, 明石昌也, 重岡学, 楠元順哉, 長谷川巧実, 古森孝英

    第62回日本口腔外科学会総会・学術大会, 2017年10月, 日本語, 京都, 国内会議

    口頭発表(一般)

  • 神経症状を伴った下顎放射線性顎骨壊死における下歯槽神経の病理組織学的研究.

    明石昌也, 楠元順哉, 長谷川巧実, 南川勉, 橋川和信, 古森孝英

    第41回日本頭頸部癌学会(京都), 2017年06月, 日本語, 日本頭頸部癌学会, 京都, 国内会議

    口頭発表(一般)

  • 4DCT EVALUATION OF CONDYLAR MOVEMEN IN PATIENTS UNDERWENT MANDIBULAR RECONSTRUCTION.

    Masaya Akashi, Toshinori Sekitani, Yumi Ohtsuki, Yasumasa Kakei, Takumi Hasegawa, Noriyuki Negi, Kazunobu Hashikawa, Yasuyuki Shibuya, Satoru Takahashi, Takahide Komori

    23nd International Conference on Oral and Maxillofacial Surgery(Hong Kong), 2017年03月, 日本語, International Conference on Oral and Maxillofacial Surgery, Hong Kong, 海外, 国内会議

    口頭発表(一般)

  • 口腔扁平上皮癌では外的刺激受容体(TRPVチャネル)の発現が亢進する.

    榊原晶子, 榊原俊介, 楠元順哉, 武田大介, 長谷川巧実, 明石昌也, 南川勉, 橋川和信, 古森孝英

    第35回口腔腫瘍学会(福岡), 2017年01月, 日本語, 口腔腫瘍学会, 福岡, 国内会議

    口頭発表(一般)

  • 内視鏡支援下で上顎洞迷入インプラントの摘出後に骨造成術を行った1例

    山下淳也, 鈴木 泰明, 筧康正, 木本 明, 長谷川巧実, 明石昌也, 古森孝英

    第20回日本顎顔面インプラント学会, 2016年12月, 日本語, 日本顎顔面インプラント学会, 東京, 国内会議

    ポスター発表

  • 当科におけるインプラント埋入症例と喪失リスクに関する臨床的検討

    片岡侑嗣, 長谷川巧実, 綿越健太, 浅井雅敏, 有本智美, 明石昌也, 鈴木 泰明, 古森孝英

    第20回日本顎顔面インプラント学会, 2016年12月, 日本語, 日本顎顔面インプラント学会, 東京, 国内会議

    ポスター発表

  • 腓骨皮弁による下顎再建におけるミニプレートと再建用プレートの比較

    平岡佑二郎, 明石昌也, 筧 康正, 楠元順哉, 榊原晶子, 長谷川巧実, 南川 勉, 橋川和信, 古森孝英

    第61回日本口腔外科学会総会・学術大会, 2016年11月, 日本語, 日本口腔外科学会, 千葉, 国内会議

    口頭発表(一般)

  • 放射線性顎骨壊死発症リスク因子の検討ー多施設共同後ろ向き研究ー

    兒島由佳, 柳本惣市, 長谷川巧実, 古森孝英, 上田順宏, 桐田忠昭, 渋谷恭之, 山田慎一, 栗田浩, 梅田正博

    第61回日本口腔外科学会総会・学術大会, 2016年11月, 日本語, 日本口腔外科学会, 千葉, 国内会議

    口頭発表(一般)

  • 当科における舌癌・口底癌手術症例の再建方法に関する検討

    綿越健太, 南川 勉, 米澤奈津季, 筧 康正, 長谷川巧実, 榊原晶子, 明石昌也, 古土井春吾, 古森孝英

    第61回日本口腔外科学会総会・学術大会, 2016年11月, 日本語, 日本口腔外科学会, 千葉, 国内会議

    ポスター発表

  • 当科における心臓血管外科開胸手術患者に対する周術期口腔機能管理の臨床的検討

    難波 渚, 明石昌也, 西井美佳, 楠元順哉, 松本耕祐, 長谷川巧実, 古土井春吾, 古森孝英

    第61回日本口腔外科学会総会・学術大会, 2016年11月, 日本語, 日本口腔外科学会, 千葉, 国内会議

    口頭発表(一般)

  • 当科における口腔癌患者の口腔内細菌数の変化とSSIについて

    小守紗也華, 長谷川巧実, 西井美佳, 明石昌也, 古土井春吾, 古森孝英

    第61回日本口腔外科学会総会・学術大会, 2016年11月, 日本語, 日本口腔外科学会, 千葉, 国内会議

    口頭発表(一般)

  • 舌癌切除後の前腕皮弁再建における 切除検体サイズと皮弁サイズの 相関と機能の検討

    榊原 晶子, 楠元 順哉, 長谷川 巧実, 明石 昌也, 南川 勉, 古土井 春吾, 橋川 和信, 古森 孝英

    第61回公益社団法人日本口腔外科学会総会・学術大会, 2016年11月, 日本語, 公益社団法人日本口腔外科学会総会・学術大会, 千葉市, 国内会議

    口頭発表(一般)

  • 舌癌切除後の前腕皮弁再建における切除検体サイズと皮弁サイズの僧冠と機能の検討

    榊原晶子, 楠元順哉, 長谷川巧実, 明石昌也, 南川勉, 古土井春吾, 橋川和信, 古森孝英

    第61回日本口腔外科学会総会・学術大会, 2016年11月, 日本語, 日本口腔外科学会, 千葉, 国内会議

    口頭発表(一般)

  • 上顎洞隔壁の形態に関する解剖学的検討

    武田大介, 長谷川巧実, 有本智美, 小松原秀紀, 鈴木泰明, 古森孝英

    第61回日本口腔外科学会総会・学術大会, 2016年11月, 日本語, 日本口腔外科学会, 千葉, 国内会議

    ポスター発表

  • 口腔癌放射線治療における有効な新規併用療法の探索

    岩田英治, 長谷川巧実, 武田大介, 斉藤 泉, 有本智美, 明石昌也, 南川 勉, 古森孝英

    第61回日本口腔外科学会総会・学術大会, 2016年11月, 日本語, 日本口腔外科学会, 千葉, 国内会議

    ポスター発表

  • 口腔癌術後リンパ浮腫に関するCT解析

    寺岡 駿, 明石昌也, 筧 康正, 楠元順哉, 榊原晶子, 長谷川巧実, 南川 勉, 橋川和信, 古森孝英

    第61回日本口腔外科学会総会・学術大会, 2016年11月, 日本語, 日本口腔外科学会, 千葉, 国内会議

    口頭発表(一般)

  • 口腔外科手術と薬剤関連性顎骨壊死に関する多施設共同後ろ向き研究

    船原隆一郎, 長谷川巧実, 川北晃子, 上田順宏, 橘 進彰, 小林正樹, 児島由佳, 小松原秀紀, 古森孝英

    第61回日本口腔外科学会総会・学術大会, 2016年11月, 日本語, 日本口腔外科学会, 千葉, 国内会議

    口頭発表(一般)

  • 局所的炭酸ガス投与による皮弁壊死抑制効果

    齊藤 泉, 長谷川巧実, 武田大介, 岩田英治, 有本智美, 榊原晶子, 明石昌也, 南川勉, 古森孝英

    第61回日本口腔外科学会総会・学術大会, 2016年11月, 日本語, 日本口腔外科学会, 千葉, 国内会議

    ポスター発表

  • 下顎枝垂直骨切り術後の骨癒合に対する低出力超音波パルス(LIPUS)の効果

    有本智美, 長谷川巧実, 齊藤 泉, 岩田英治, 武田大介, 立石千鶴, 明石昌也, 鈴木泰明, 古土井春吾, 古森孝英

    第61回日本口腔外科学会総会・学術大会, 2016年11月, 日本語, 日本口腔外科学会, 千葉, 国内会議

    ポスター発表

  • 遠位レベル(Level IV,V)への頸部リンパ節転移を生じた口腔扁平上皮癌患者の予後に関する後ろ向き観察研究

    長谷川巧実, 南川 勉, 米澤奈津季, 高橋佑輔, 筧 康正, 榊原晶子, 明石昌也, 古森孝英

    第61回日本口腔外科学会総会・学術大会, 2016年11月, 日本語, 日本口腔外科学会, 千葉, 国内会議

    口頭発表(一般)

  • シンポジウム1:「抜くべきか 抜かざるべきか それが問題だ」骨吸収抑制剤患者における抜歯前休薬と術中処置について

    長谷川巧実, 古土井春吾, 古森孝英

    第12回日本口腔ケア協会学術大会, 2016年11月, 日本語, 日本口腔ケア協会, 長崎, 国内会議

    口頭発表(一般)

  • Development of the new treatment of OSCC by local application of transcutaneous carbon dioxide

    Iwata E, Hasegawa T, Takeda D, Saito I, Arimoto S, Akashi M, Minamikawa T, Komori T

    The 23rd European Association for Cranio Maxillo-Facial Surgery (EACMFS), 2016年09月, 日本語, UKレーザー歯学会, London, UK, 国際会議

    ポスター発表

  • Determination of resection margins by using a combination of CT, MRI, PET, and 3D model in osteoradionecrosis of the jaw

    Masaya Akashi, Kazunobu Hashikawa, Satoshi Wanifuchi, Megumi Kishimoto, Eiji Iwata, Yasumasa Kakei, Junya Kusumoto, Kousuke Matsumoto, Akiko Sakakibara, Takumi Hasegawa, Tsutomu Minamikawa, Shungo Furudoi, Takahide Komori

    The 23th Congress of EACMFS, 2016年09月, 英語, Congress of EACMFS, London, イギリス, 国際会議

    口頭発表(一般)

  • Determination of resection margins by using a combination of CT, MRI, PET, and 3D model in osteoradionecrosis of the jaw

    Akashi M, Hashikawa K, Wanifuchi S, Kishimoto M, Iwata E, Kakei Y, Kusumoto J, Matsumoto K, Sakakibara A, Hasegawa T, Minamikawa T, Furudoi S, Komori T

    The 23rd European Association for Cranio Maxillo-Facial Surgery (EACMFS), 2016年09月, 日本語, UKレーザー歯学会, London, UK, 国際会議

    ポスター発表

  • Changes of cell junctions induced by EGFR inhibition in oral squamous cell carcinomas

    Kakei Y, Akashi M, Teraoka S, Hasegawa T, Komori T

    The 23rd European Association for Cranio Maxillo-Facial Surgery (EACMFS), 2016年09月, 日本語, UKレーザー歯学会, London, UK, 国際会議

    ポスター発表

  • A clinical study of injured patients treated with dental implants

    Suzuki H, Takeuchi J, Matsuo K, Kakei Y, Kimoto A, Hasegawa T, Akashi M, Chikazu D, Komori T

    The 23rd European Association for Cranio Maxillo-Facial Surgery (EACMFS), 2016年09月, 日本語, UKレーザー歯学会, London, UK, 国際会議

    ポスター発表

  • A clinical study of 12 implants resulting in implant removal

    Takahashi D, Suzuki H, Kakei Y, Hasegawa T, Akashi M, Minamikawa T, Takahide Komori

    The 23rd European Association for Cranio Maxillo-Facial Surgery (EACMFS),, 2016年09月, 日本語, UKレーザー歯学会, London, UK, 国際会議

    ポスター発表

  • 当科における心臓血管外科周術期の口腔機能管理に関する実態と今後の課題

    難波 渚, 明石昌也, 冨田 和, 田村恵利, 澤田麻衣子, 西井美佳, 長谷川巧実, 古土井春吾, 古森孝英

    第32回兵庫県歯科医学大会, 2016年07月, 日本語, 兵庫県歯科医師会, 神戸, 国内会議

    口頭発表(一般)

  • 上顎智歯抜歯のおける上顎洞穿孔リスクとその対応について

    長谷川巧実, 橘 進彰, 古森孝英

    第32回兵庫県歯科医学大会, 2016年07月, 日本語, 兵庫県歯科医師会, 神戸, 国内会議

    口頭発表(一般)

  • 下顎骨骨折の治療を行ったLennox-Gastaut症候群患児の1例

    中西洋介, 松本耕祐, 小守紗也華, 長谷川巧実, 明石昌也, 柚鳥宏和, 橘進彰, 古森孝英

    第16回日本外傷歯学会総会・学術大会, 2016年07月, 日本語, 日本外傷歯学会, 神戸, 国内会議

    口頭発表(一般)

  • 歯科インプラント埋入のためのデンタルCTを用いた移植腓骨の形態評価

    明石昌也, 橋川和信, 鰐渕 聡, 楠元順哉, 長谷川巧実, 南川 勉, 寺師浩人, 古森孝英

    第40回日本頭頸部癌学会総会・学術大会, 2016年06月, 日本語, 日本頭頸部癌学会, 埼玉, 国内会議

    口頭発表(一般)

  • 歯科インプラント埋入のためのデンタルCTを用いた移植腓骨の形態評価

    明石 昌也, 橋川 和信, 鰐渕聡, 楠元 順哉, 長谷川巧実, 南川勉, 寺師 浩人, 古森 孝英

    第40回日本頭頸部癌学会, 2016年06月, 日本語, 日本頭頸部癌学会, さいたま市, 国内会議

    口頭発表(一般)

  • 口腔癌病理学的再発高リスク例に対する術後補助療法の検討

    長谷川巧実, 大鶴光信, 柳本惣市, 南川 勉, 太田嘉英, 梅田正博, 古森孝英

    第40回日本頭頸部癌学会総会・学術大会, 2016年06月, 日本語, 日本頭頸部癌学会, 埼玉, 国内会議

    口頭発表(一般)

  • 下顎歯肉がんのT分類(多施設共同後ろ向き研究 JOOG RA-1401)

    大倉正也, 伊藤 章, 太田嘉英, 大鶴光信, 梅田正博, 柳本惣市, 桐田忠昭, 山川延宏, 長谷川巧実, 古森孝英, 栗田 浩, 鎌田孝広, 上田倫弘

    第40回日本頭頸部癌学会総会・学術大会, 2016年06月, 日本語, 日本頭頸部癌学会, 埼玉, 国内会議

    口頭発表(一般)

  • 下顎枝垂直骨切り術後の骨癒合に対する低出力超音波パルス(LIPUS)の効果

    有本智美, 長谷川巧実, 岡本奈那, 塩屋園敦, 立石千鶴, 明石昌也, 鈴木泰明, 古土井春吾, 古森孝英

    第26回日本顎変形症学会総会・学術大会, 2016年06月, 日本語, 日本顎変形症学会, 東京, 国内会議

    ポスター発表

  • 下顎骨偏位と乳様突起体積および頭位に関する検討

    塩屋園敦, 立石千鶴, 浅井雅敏, 有本智美, 岡本奈那, 長谷川巧実, 鈴木泰明, 古土井春吾, 古森孝英

    第26回日本顎変形症学会総会・学術大会, 2016年06月, 日本語, 日本顎変形症学会, 東京, 国内会議

    ポスター発表

  • T2N0M0舌癌に予防郭清を行うことの是非に関する多施設共同研究(JOOG RA1403)

    大鶴光信, 太田嘉英, 梅田正博, 柳本惣市, 栗田 浩, 鎌田孝広, 桐田忠昭, 山川延宏, 上田倫弘, 山下徹郎, 大倉正也, 相川友直, 大廣洋一, 栗林和代, 山下善弘, 長井健太郎, 野口一馬, 岸本裕充, 長谷川巧実, 古森孝英, 傳田祐也, 内藤博之, 柴原孝彦, 野口忠秀, 唐木田一成

    第40回日本頭頸部癌学会総会・学術大会, 2016年06月, 日本語, 日本頭頸部癌学会, 埼玉, 国内会議

    口頭発表(一般)

  • 当科における埋伏智歯抜歯後神経系合併症に対する治療法の現状

    平岡佑二郎, 明石昌也, 松本耕祐, 榊原晶子, 木本 明, 長谷川巧実, 鈴木泰明, 南川勉, 古土井春吾, 古森孝英

    第70回日本口腔科学会総会・学術大会, 2016年04月, 日本語, 日本口腔科学会, 福岡, 国内会議

    口頭発表(一般)

  • 当科におけるFibro-osseous lesionsの臨床的検討

    松尾健司, 明石昌也, 筧 康正, 松本耕祐, 長谷川巧実, 南川 勉, 古土井春吾, 橘進彰, 古森孝英

    第70回日本口腔科学会総会・学術大会, 2016年04月, 日本語, 日本口腔科学会, 福岡, 国内会議

    口頭発表(一般)

  • 遺伝子解析により確定診断を得たMALTリンパ腫の1例

    筧 康正, 明石昌也, 木本 明, 長谷川巧実, 南川 勉, 古森孝英

    第70回日本口腔科学会総会・学術大会, 2016年04月, 日本語, 日本口腔科学会, 福岡, 国内会議

    口頭発表(一般)

  • 腓骨皮弁採取部における一期縫縮と植皮の比較

    渡邊一博, 明石昌也, 楠本順哉, 松本耕祐, 木本 明, 榊原晶子, 長谷川巧実, 南川勉, 橋川和信, 古森孝英

    第34回日本口腔腫瘍学会総会・学術大会, 2016年01月, 日本語, 日本口腔腫瘍学会, 横浜, 国内会議

    ポスター発表

  • 術前18F-FDG PET/CT撮影での口腔癌原発巣における定量評価の有用性

    米澤奈津季, 南川 勉, 北島一宏, 高橋佑輔, 筧 康正, 榊原晶子, 長谷川巧実, 明石昌也, 古森孝英

    第34回日本口腔腫瘍学会総会・学術大会, 2016年01月, 日本語, 日本口腔腫瘍学会, 横浜, 国内会議

    ポスター発表

  • 口腔扁平上皮癌被膜外浸潤症例の臨床病理学的検討

    筧 康正, 南川 勉, 寺岡 駿, 米澤奈津季, 高橋佑輔, 長谷川巧実, 明石昌也, 古森孝英

    第34回日本口腔腫瘍学会総会・学術大会, 2016年01月, 日本語, 日本口腔腫瘍学会, 横浜, 国内会議

    ポスター発表

  • 口腔扁平上皮癌患者の遠位レベル(level4,5)への頸部リンパ節転移が予後に与える影響

    定兼啓倫, 長谷川巧実, 渋谷恭之, 米澤奈津季, 武田大介, 高橋佑輔, 筧 康正, 明石昌也, 南川 勉, 古土井春吾, 橋川和信, 古森孝英

    第34回日本口腔腫瘍学会総会・学術大会, 2016年01月, 日本語, 日本口腔腫瘍学会, 横浜, 国内会議

    ポスター発表

  • 口腔扁平上皮癌における外的刺激受容体(TRPVチャネル)の発現

    榊原 晶子, 榊原 俊介, 楠元 順哉, 武田 大介, 長谷川 巧実, 明石 昌也, 南川 勉, 橋川 和信, 古森 孝英

    第34回日本口腔腫瘍学会総会・学術大会, 2016年01月, 日本語, 日本口腔腫瘍学会総会・学術大会, 横浜市, 国内会議

    口頭発表(一般)

  • 口腔扁平上皮癌における外的刺激受容体(TRPVチャネル)の発現亢進

    榊原晶子, 榊原俊介, 楠元順哉, 武田大介, 長谷川巧実, 明石昌也, 南川 勉, 橋川和信, 古森孝英

    第34回日本口腔腫瘍学会総会・学術大会, 2016年01月, 日本語, 日本口腔腫瘍学会, 横浜, 国内会議

    ポスター発表

  • 口腔癌再発高リスク例に対する高用量CDDP併用術後補助化学放射線療法の検討

    長谷川巧実, 柳本惣市, 大鶴光信, 山川延広, 山田慎一, 南川 勉, 太田嘉英, 梅田正博, 大倉正也, 栗田 浩, 桐田忠昭, 上田倫弘, 古森孝英

    第34回日本口腔腫瘍学会総会・学術大会, 2016年01月, 日本語, 日本口腔腫瘍学会, 横浜, 国内会議

    口頭発表(一般)

  • 局所的炭酸ガス投与による皮弁壊死抑制効果

    齊藤 泉, 長谷川巧実, 武田大介, 岩田英治, 有本智美, 筧康正, 高橋佑輔, 榊原晶子, 明石昌也, 南川勉, 古森孝英

    第34回日本口腔腫瘍学会総会・学術大会, 2016年01月, 日本語, 日本口腔腫瘍学会, 横浜, 国内会議

    ポスター発表

  • 移植腓骨と下顎骨の癒合における骨膜温存の重要性(ポスター発表)

    明石昌也, 筧 康正, 榊原晶子, 長谷川巧実, 南川 勉, 橋川和信, 古森孝英

    第34回日本口腔腫瘍学会総会・学術大会, 2016年01月, 日本語, 日本口腔腫瘍学会, 横浜, 国内会議

    ポスター発表

  • 移植腓骨と下顎骨の癒合における骨膜温存の重要性

    明石 昌也, 筧 康正, 榊原 晶子, 長谷川 巧実, 南川 勉, 橋川 和信, 古森 孝英

    第34回日本口腔腫瘍学会総会・学術大会, 2016年01月, 日本語, 日本口腔腫瘍学会総会・学術大会, 横浜市, 国内会議

    口頭発表(一般)

  • 入院管理下で口腔外科小手術を施行した患者に関する臨床統計

    棚倉 万紀子, 筧 康正, 南川 勉, 高橋 佑輔, 米澤 奈津季, 榊原 晶子, 長谷川 巧実, 明石 昌也, 古森 孝英

    第60回日本口腔外科学会総会, 2015年10月, 日本語, 日本口腔外科学会, 名古屋, 国内会議

    口頭発表(一般)

  • 超音波断層法による口腔癌頸部リンパ節転移の検討

    筧 康正, 南川 勉, 棚倉 万紀子, 米澤 奈津季, 高橋 佑輔, 松井 太輝, 長谷川 巧実, 明石 昌也, 重田 崇至, 古森 孝英

    第60回日本口腔外科学会総会, 2015年10月, 日本語, 日本口腔外科学会, 名古屋, 国内会議

    口頭発表(一般)

  • 多施設における過去5年の下顎骨骨折症例の検討~下顎智歯と骨折部位の関係

    定兼 啓倫, 長谷川 巧実, 小林 正樹, 橘彰, 尾古 俊哉, 石田 佳毅, 藤田 剛史, 竹野々 厳, 小松原 秀紀, 竹内 純一郎, 市来 浩司, 宮井 大介, 古森 孝英

    第60回日本口腔外科学会総会, 2015年10月, 日本語, 日本口腔外科学会, 名古屋, 国内会議

    口頭発表(一般)

  • 三次元実態模型を用いた手術シミュレーションー当科における最近の使用経験

    鰐渕 聡, 明石 昌也, 橋川和信, 筧 康正, 松本 耕祐, 木本 明, 長谷川 巧実, 南川 勉, 古土井 春吾, 古森 孝英

    第60回日本口腔外科学会総会, 2015年10月, 日本語, 日本口腔外科学会, 名古屋, 国内会議

    口頭発表(一般)

  • 抗血栓療法患者における抜歯後出血危険因子についての多施設共同研究-抗凝固療法について-

    小守 紗也華, 長谷川 巧実, 柳本惣市, 六反田賢, 渋谷 恭之, 橘 進彰, 児島 由佳, 梅田 正博, 古森 孝英

    第60回日本口腔外科学会総会, 2015年10月, 日本語, 日本口腔外科学会, 名古屋, 国内会議

    口頭発表(一般)

  • 口腔癌術後再発高リスク例に対する放射線化学療法の検討

    長谷川 巧実, 柳本惣市, 太田嘉英, 梅田正博, 大倉正也, 栗田 浩, 桐田忠昭, 上田倫弘, 古森 孝英

    第60回日本口腔外科学会総会., 2015年10月, 日本語, 日本口腔外科学会, 名古屋, 国内会議

    口頭発表(一般)

  • 口腔癌原発巣の術前18F-FDG PET/CT撮影に関する検討

    米澤 奈津季, 南川 勉, 北島一宏, 高橋 佑輔, 筧 康正, 榊原 晶子, 長谷川 巧実, 明石 昌也, 古森 孝英

    第60回日本口腔外科学会総会, 2015年10月, 日本語, 日本口腔外科学会, 名古屋, 国内会議

    口頭発表(一般)

  • 経皮的炭酸ガス投与による口腔癌上皮間葉移行の抑制効果

    岩田 英治, 長谷川 巧実, 武田 大介, 明石 昌也, 南川 勉, 古森 孝英

    第60回日本口腔外科学会総会, 2015年10月, 日本語, 日本口腔外科学会, 名古屋, 国内会議

    口頭発表(一般)

  • ロケーター・マグネット付きカスタムバーによるインプラントオーバーデンチャー関連合併症

    有本 智美, 長谷川 巧実, 斉藤 泉, 岩田 英治, 武田 大介, 明石 昌也, 鈴木 泰明, 古土井 春吾, 古森 孝英

    第60回日本口腔外科学会総会., 2015年10月, 日本語, 日本口腔外科学会, 名古屋, 国内会議

    口頭発表(一般)

  • Observation of Mastication in Patients Underwent Mandibular Reconstruction by 4D-CT with 320 Detector-Row Scanning : A Preliminary Report,

    Akashi M, Shibuya Y, Takahashi S, Hashikawa K, Hasegawa T, Kakei Y, Negi N, Sekitani T, Komori T

    22nd International conference on oral and maxilofacial surgery,, 2015年10月, 英語, メルボルン, オーストラリア, 国際会議

    口頭発表(一般)

  • Incidence of venousthromboembolism after oral surgery with simultaneous reconstruction,

    Kakei Y, Akashi M, Shigeta T, Takahashi Y, Mastui T, Sakakibara A, Hasegawa T, Minamikawa T, Komori T

    22nd International conference on oral and maxilofacial surgery,, 2015年10月, 英語, メルボルン, オーストラリア, 国際会議

    口頭発表(一般)

  • Evaluation of progression level of extracapsular spread for cervical lymph node metastasis of oral squamous cell carcinoma: a multicenter retrospective study.

    Yamada S, Yanamoto S, Hasegawa T, Miyakoshi M, Ooga N, Kamata T, Komori T, Kitagawa Y, Kurita H, Umeda M

    22nd International conference on oral and maxilofacial surgery,, 2015年10月, 英語, メルボルン, オーストラリア, 国際会議

    口頭発表(一般)

  • Evaluating the changes in the amount of bone augmentation after sinus lift using panoramic radiography: Comparison evaluations based on CT images.

    松尾 健司, 鈴木 泰明, 松本 耕祐, 木本 明, 長谷川 巧実, 明石 昌也, 竹内 順一郎, 古森 孝英

    第60回日本口腔外科学会総会., 2015年10月, 日本語, 日本口腔外科学会, 名古屋, 国内会議

    口頭発表(一般)

  • A novel strategy aimed at apoptosis via the mitochondrial pathway and improving hypoxia in oral squamous cell carcinoma..

    武田 大介, 長谷川 巧実, 榊原 晶子, 明石 昌也, 南川 勉, 古森 孝英

    第60回日本口腔外科学会総会, 2015年10月, 日本語, 日本口腔外科学会, 名古屋, 国内会議

    口頭発表(一般)

  • 当院における周術期口腔機能管理に関する実態調査と今後の課題

    田村 惠利, 西井 美佳, 冨田 和, 難波 渚, 長谷川 巧実, 明石 昌也, 古土井 春吾, 古森 孝英

    第12回日本口腔ケア学会総会・学術大会., 2015年06月, 日本語, 日本口腔ケア学会, 山口, 国内会議

    口頭発表(一般)

  • 外科的矯正手術前後における顎関節症状および顎関節MRI画像の変化.

    定兼 啓倫, 長谷川 巧実, 有本 智美, 岡本 奈那, 塩屋園 敦, 立石 千鶴, 明石 昌也, 鈴木 泰明, 古土井 春吾, 古森 孝英

    第25回日本顎変形症学会総会., 2015年06月, 日本語, 日本顎変形症学会, 東京, 国内会議

    口頭発表(一般)

  • Sequential evaluation of bone union of transferred fibula flaps in reconstructed mandibles.

    Akashi M, Hashikawa K, Kakei Y, Sakakibara A, Hasegawa T, Minamikawa T, Komori T

    "The Joint Meeting of 4th Congress of Asian Society of Head and Neck Oncology & 39th Annual Meeting of Japan society for Head and Neck Cancer., 2015年06月, 英語, 神戸, 国内会議

    口頭発表(一般)

  • Decreased mitochondrial copy numbers in oral squamous cell carcinoma.

    Takeda D, Hasegawa T, Sakakibara A, Akashi M, Minamikawa T, Komori T

    "The Joint Meeting of 4th Congress of Asian Society of Head and Neck Oncology & 39th Annual Meeting of Japan society for Head and Neck Cancer., 2015年06月, 英語, 神戸, 国内会議

    口頭発表(一般)

  • -

    難波 渚, 西井 美佳, 冨田 和, 田村 恵利, 長谷川 巧実, 明石 昌也, 古土井 春吾, 古森 孝英

    第12回日本口腔ケア学会総会・学術大会., 2015年06月, 日本語, 日本口腔ケア学会, 山口, 国内会議

    口頭発表(一般)

  • 予後不良症例を考える-症例検討会- 口腔・頸部は制御されたが、肺転移を認めた1例

    長谷川 巧実, 南川 勉, 古森 孝英

    第33回日本口腔腫瘍学会, 2015年01月, 日本語, 日本口腔腫瘍学会総会, 奈良, 国内会議

    口頭発表(一般)

  • 当科における頸部郭清術術後の頸部ドレーンに関する臨床的検討

    齊藤 泉, 長谷川 巧実, 米澤 奈津季, 武田 大介, 高橋 佑輔, 筧 康正, 松井 太輝, 榊原 晶子, 明石 昌也, 南川 勉, 古森 孝英

    第33回日本口腔腫瘍学会, 2015年01月, 日本語, 日本口腔腫瘍学会, 奈良, 国内会議

    口頭発表(一般)

  • 当科における放射線性顎骨壊死に関する臨床的検討

    鰐渕 聡, 明石 昌也, 筧 康正, 榊原 晶子, 長谷川 巧実, 南川 勉, 古森 孝英

    第33回日本口腔腫瘍学会, 2015年01月, 日本語, 日本口腔腫瘍学会, 奈良, 国内会議

    口頭発表(一般)

  • 当科における口腔扁平上皮癌遠隔転移例の臨床的検討とリスク因子について

    棚倉 万紀子, 長谷川 巧実, 米澤 奈津季, 武田 大介, 高橋 佑輔, 筧 康正, 榊原 晶子, 明石 昌也, 南川 勉, 古森 孝英

    第33回日本口腔腫瘍学会, 2015年01月, 日本語, 日本口腔腫瘍学会, 奈良, 国内会議

    口頭発表(一般)

  • 口腔扁平上皮癌臨床検体におけるミトコンドリア量について

    武田 大介, 長谷川 巧実, 今井 佑輔, 榊原 晶子, 明石 昌也, 南川 勉, 古森 孝英

    第33回日本口腔腫瘍学会, 2015年01月, 日本語, 日本口腔腫瘍学会, 奈良, 国内会議

    ポスター発表

  • 口腔癌術後再発ハイリスク因子を規定する被膜外浸潤の伸展度分類

    大谷 昇平, 山田 慎一, 柳本 惣市, 長谷川 巧実, 宮腰 昌明, 大賀 典孝, 鎌田 孝広, 古森 孝英, 北川 善政, 栗田 浩, 朝比奈泉, 梅田正博

    第33回日本口腔腫瘍学会, 2015年01月, 日本語, 日本口腔腫瘍学会, 奈良, 国内会議

    口頭発表(一般)

  • 口腔癌手術症例におけるmodified Glasgow Prognostic Score(mGPS)を用いた長期予後に関する検討

    平岡 佑二郎, 南川 勉, 米澤 奈津季, 高橋 佑輔, 榊原 晶子, 長谷川 巧実, 明石 昌也, 古森 孝英

    第33回日本口腔腫瘍学会, 2015年01月, 日本語, 日本口腔腫瘍学会, 奈良, 国内会議

    ポスター発表

  • 口腔癌原発巣におけるDual-time-point FDG PETの有用性

    米澤 奈津季, 南川 勉, 高橋 佑輔, 筧 康正, 松井 太輝, 榊原 晶子, 長谷川 巧実, 明石 昌也, 古森 孝英

    第33回日本口腔腫瘍学会, 2015年01月, 日本語, 日本口腔腫瘍学会, 奈良, 国内会議

    口頭発表(一般)

  • 下顎枝垂直骨切り術後の近位骨片と下顎頭変化の評価

    有本 智美, 長谷川 巧実, 定兼 啓倫, 岡本 奈那, 塩屋園 敦, 立石 千鶴, 明石 昌也, 鈴木 泰明, 古土井 春吾, 古森 孝英

    第25回日本顎変形症学会総会., 2015年01月, 日本語, 日本顎変形症学会, 東京, 国内会議

    口頭発表(一般)

  • 放射線治療後の甲状腺機能低下による低ナトリウム血症の1例

    村田 陽太郎, 長谷川 巧実, 八橋 明子, 明石 昌也, 南川 勉, 古土井 春吾, 古森 孝英

    第26回日本口腔科学会近畿地方部会, 2014年12月, 日本語, 日本口腔科学会, 京都, 国内会議

    口頭発表(一般)

  • 当科における広範囲顎骨支持型インプラント補綴の臨床統計的検討

    今井 佑輔, 長谷川 巧実, 川畑 真哉, 武田 大介, 明石 昌也, 鈴木 泰明, 古森 孝英

    第18回日本顎顔面インプラント学会学術大会, 2014年11月, 日本語, 日本顎顔面インプラント学会, 島根, 国内会議

    口頭発表(一般)

  • 当科におけるインプラント242例907本埋入に関する臨床的検討

    川畑 真哉, 長谷川 巧実, 今井 佑輔, 木本 明, 明石 昌也, 鈴木 泰明, 古森 孝英

    第18回日本顎顔面インプラント学会学術大会, 2014年11月, 日本語, 日本顎顔面インプラント学会, 島根, 国内会議

    口頭発表(一般)

  • 著明な上顎洞粘膜肥厚を有する患者に洞底挙上術後インプラント治療を行った症例

    榎本 由依, 鈴木 泰明, 木本 明, 長谷川 巧実, 明石 昌也, 竹内 純一郎, 古森 孝英

    第18回日本顎顔面インプラント学会学術大会, 2014年11月, 日本語, 日本顎顔面インプラント学会, 島根, 国内会議

    口頭発表(一般)

  • 歯科インプラント埋入のためのCT画像を用いた移植腓骨の形態評価

    明石 昌也, 渋谷 恭之, 鰐渕 聡, 木本 明, 長谷川 巧実, 鈴木 泰明, 古森 孝英

    第18回日本顎顔面インプラント学会学術大会, 2014年11月, 日本語, 日本顎顔面インプラント学会, 島根, 国内会議

    口頭発表(一般)

  • 当科における上顎洞底挙上術後の骨量変化の臨床的検討

    寺岡 駿, 鈴木 泰明, 筧 康正, 石田 優, 木本 明, 長谷川 巧実, 浅井 知子, 竹内 純一郎, 渋谷 恭之, 古森 孝英

    第59回日本口腔外科学会総会, 2014年10月, 日本語, 日本口腔外科学会, 千葉, 国内会議

    口頭発表(一般)

  • 当科における口腔癌患者の術後せん妄に関する臨床的検討

    齊藤 泉, 長谷川 巧実, 米澤 奈津季, 高橋 佑輔, 筧 康正, 松井 太輝, 榊原 晶子, 明石 昌也, 南川 勉, 古森 孝英

    第59回日本口腔外科学会総会, 2014年10月, 日本語, 日本口腔外科学会, 千葉, 国内会議

    口頭発表(一般)

  • 低出力超音波パルスの下顎骨骨折血腫細胞のBMP発現における効果

    黄 文蘇, 長谷川 巧実, 今井 佑輔, 武田 大介, 明石 昌也, 古森 孝英

    第59回日本口腔外科学会総会, 2014年10月, 日本語, 日本口腔外科学会, 千葉, 国内会議

    ポスター発表

  • 上顎部分切除後の遊離前腕皮弁再建群と非再建群の比較

    明石 昌也, 渋谷 恭之, 楠元 順哉, 榊原 晶子, 長谷川 巧実, 南川 勉, 古土井 春吾, 橋川 和信, 古森 孝英

    第59回日本口腔外科学会総会, 2014年10月, 日本語, 日本口腔外科学会, 千葉, 国内会議

    口頭発表(一般)

  • 抗RANKLモノクローナル抗体(デノスマブ)に発症した顎骨壊死の1例

    岩田 英治, 明石 昌也, 長谷川 巧実, 古土井 春吾, 古森 孝英

    第23回日本口腔感染症学会総会, 2014年10月, 日本語, 日本口腔感染症学会, 伊丹, 国内会議

    口頭発表(一般)

  • 口腔扁平上皮癌N0症例への予防的頸部郭清の検討:T1-2とT3-4の比較

    八橋 明子, 南川 勉, 松井 太輝, 高橋 佑輔, 米澤 奈津季, 筧 康正, 榊原 晶子, 長谷川 巧実, 明石 昌也, 古森孝英

    第59回日本口腔外科学会総会, 2014年10月, 日本語, 日本口腔外科学会, 千葉, 国内会議

    ポスター発表

  • 口腔癌手術における輸血療法の現状

    米澤 奈津季, 南川 勉, 高橋 佑輔, 筧 康正, 松井 太輝, 榊原 晶子, 長谷川 巧実, 明石 昌也, 渋谷恭之, 古森 孝英

    第59回日本口腔外科学会総会, 2014年10月, 日本語, 日本口腔外科学会, 千葉, 国内会議

    口頭発表(一般)

  • 口腔癌に対する救済手術についての検討

    筧 康正, 南川 勉, 米澤 奈津季, 高橋 佑輔, 松井 太輝, 榊原 晶子, 長谷川 巧実, 明石 昌也, 渋谷 恭之, 古森孝英

    第59回日本口腔外科学会総会, 2014年10月, 日本語, 日本口腔外科学会, 千葉, 国内会議

    口頭発表(一般)

  • 局所的炭酸ガス投与による口腔癌新規治療法の開発

    武田 大介, 長谷川 巧実, 今井 佑輔, 榊原 晶子, 明石 昌也, 南川 勉, 渋谷 恭之, 古森 孝英

    第59回日本口腔外科学会総会, 2014年10月, 日本語, 日本口腔外科学会, 千葉, 国内会議

    ポスター発表

  • 急速に増大し巨舌を呈した多発性骨髄腫に伴うアミロイドーシスの1例

    藤田 剛史, 井堂 信二郎, 大槻 有美, 江崎 友美, 北里 佑香, 長谷川 巧実, 古森 孝英

    第59回日本口腔外科学会総会, 2014年10月, 日本語, 日本口腔外科学会, 千葉, 国内会議

    口頭発表(一般)

  • 化学放射線療法中の中咽頭癌患者における口腔乾燥の経時的変化

    西井 美佳, 明石 昌也, 筧 康正, 長谷川 巧実, 南川 勉, 古土井 春吾, 渋谷 恭之, 古森 孝英

    第59回日本口腔外科学会総会, 2014年10月, 日本語, 日本口腔外科学会, 千葉, 国内会議

    口頭発表(一般)

  • フェーズラグCT(pl-CTA)による顎骨周囲の脈管の評価

    榊原 晶子, 榊原 俊介, 長谷川 巧実, 明石 昌也

    第59回日本口腔外科学会総会・学術集会, 2014年10月, 日本語, 日本口腔外科学会, 幕張, 国内会議

    口頭発表(一般)

  • フェーズラグCTA(pl-CTA)による顎動静脈分岐の評価

    榊原 晶子, 榊原 俊介, 楠元 順哉, 長谷川 巧実, 明石 昌也, 鈴木 泰明, 南川 勉, 古土井 春吾, 橋川 和信, 古森 孝英

    第59回日本口腔外科学会総会, 2014年10月, 日本語, 日本口腔外科学会, 千葉, 国内会議

    口頭発表(一般)

  • ビスフォスフォネート関連顎骨壊死症例のCT画像における臨床的検討

    岩田 英治, 明石 昌也, 楠元 順哉, 長谷川 巧実, 後藤 育子, 古土井 春吾, 古森 孝英

    第59回日本口腔外科学会総会, 2014年10月, 日本語, 日本口腔外科学会, 千葉, 国内会議

    ポスター発表

  • 顎矯正手術における超音波診断法と単純MRI画像を用いた顎動脈の走行位置評価

    有本 智美, 長谷川 巧実, 金子 児太郎, 岡本 奈那, 塩屋園 敦, 立石 千鶴, 古土井 春吾, 渋谷 恭之, 古森 孝英

    第24回日本j顎変形症学会総会, 2014年06月, 日本語, 日本顎変形症学会, 福岡, 国内会議

    口頭発表(一般)

  • 口腔癌再建術後の頸部感染評価目的でのCTの有用性

    明石 昌也, 古土井 春吾, 南川 勉, 木本 明, 榊原 晶子, 長谷川 巧実, 後藤 育子, 渋谷 恭之, 古森 孝英

    第68回日本口腔科学会学術総会, 2014年05月, 日本語, 日本口腔科学会, 東京, 国内会議

    口頭発表(一般)

  • 口腔癌cN1症例に対する頸部郭清術の廓清範囲についての検討

    筧 康正, 南川 勉, 高橋 佑輔, 松井 太輝, 長谷川 巧実, 明石 昌也, 重田 崇至, 古土井 春吾, 渋谷 恭之, 古森 孝英

    第32回日本口腔腫瘍学会, 2014年01月, 日本語, 日本口腔腫瘍学会, 札幌, 国内会議

    口頭発表(一般)

  • 40歳未満に発生した舌扁平上皮癌21例の検討

    高橋 佑輔, 南川 勉, 長谷川 巧実, 米澤 奈津季, 筧 康正, 松井 太輝, 榊原 晶子, 重田 崇至, 渋谷 恭之, 古森 孝英

    第32回日本口腔腫瘍学会, 2014年01月, 日本語, 日本口腔腫瘍学会, 札幌, 国内会議

    口頭発表(一般)

  • 頸部郭清術後に発症した偽膜性腸炎から中毒性巨大結腸症に至った1例

    岩田英治, 古土井春吾, 高橋佑輔, 長谷川巧実, 南川 勉, 渋谷恭之, 古森孝英

    第22回口腔感染症学会総会, 2013年11月, 日本語, 口腔感染症学会, 八王子, 国内会議

    口頭発表(一般)

  • 当科におけるインプラントの撤去に至った21症例の臨床的検討

    高端大希, 鈴木泰明, 石田 優, 長谷川巧実, 浅井知子, 竹内純一郎, 渋谷恭之, 古森孝英

    第17回顎顔面インプラント学会総会, 2013年11月, 日本語, 顎顔面インプラント学会, 東京, 国内会議

    口頭発表(一般)

  • 下顎のスプリットクレスト法において遊離骨片が生じた6例の臨床的検討

    八橋明子, 石田 優, 仲村百合香, 小林正樹, 長谷川巧実, 鈴木泰明, 渋谷恭之, 古森孝英

    第17回顎顔面インプラント学会総会, 2013年11月, 日本語, 顎顔面インプラント学会, 東京, 国内会議

    口頭発表(一般)

  • CT画像における下顎骨舌側にみられる骨孔の観察

    浅井知子, 渋谷恭之, 仲村百合香, 長谷川巧実, 鈴木泰明, 古森孝英

    第17回顎顔面インプラント学会総会, 2013年11月, 日本語, 顎顔面インプラント学会, 東京, 国内会議

    口頭発表(一般)

  • 放射線治療を伴う上顎切除後に骨移植を併用したインプラント顎義歯を用いて機能回復を行った1例

    井堂信二郎, 小林正樹, 長谷川巧実, 鈴木泰明, 渋谷恭之, 古森孝英

    第33回日本口腔インプラント学会近畿北陸支部学術大会, 2013年10月, 日本語, 日本口腔インプラント学会, 神戸, 国内会議

    口頭発表(一般)

  • 舌半側切除後の遊離前腕皮弁再建症例における長期観察結果.

    明石 昌也, 橋川 和信, 榊原 晶子, 長谷川 巧実, 重田 崇至, 南川 勉, 古土井 春吾, 渋谷 恭之, 古森 孝英

    第58回日本口腔外科学会総会・学術大会, 2013年10月, 日本語, 日本口腔外科学会総会・学術大会, 福岡市, 国内会議

    口頭発表(一般)

  • 抗血栓療法下での抜歯後出血の臨床的検討

    松本耕祐, 李 進彰, 宮井大介, 柚鳥宏和, 重田崇至, 長谷川巧実, 津々見由里, 小守紗也華, 古森孝英

    第58回日本口腔外科学会総会, 2013年10月, 日本語, 日本口腔外科学会, 福岡, 国内会議

    口頭発表(一般)

  • 口腔癌頸部郭清術後の郭清範囲内および境界領域における頸部再発に関する検討

    高橋佑輔, 南川 勉, 米澤奈津季, 榊原晶子, 筧 康正, 松井太輝, 長谷川巧実, 重田崇至, 渋谷恭之, 古森孝英

    第58回日本口腔外科学会総会, 2013年10月, 日本語, 日本口腔外科学会, 福岡, 国内会議

    口頭発表(一般)

  • 口腔癌患者における胃瘻造設に関する検討―術中同時胃瘻造設について-

    米澤奈津季, 南川 勉, 明石昌也, 高橋佑輔, 長谷川巧実, 榊原晶子, 重田崇至, 渋谷恭之, 古森孝英

    第58回日本口腔外科学会総会, 2013年10月, 日本語, 日本口腔外科学会, 福岡, 国内会議

    口頭発表(一般)

  • 下顎骨骨折血腫由来細胞の骨分化能に対するBP製剤の効果

    今井佑輔, 長谷川巧実, 武田大介, 黄 文蘇, 渋谷恭之, 古森孝英

    第58回日本口腔外科学会総会, 2013年10月, 日本語, 日本口腔外科学会, 福岡, 国内会議

    ポスター発表

  • ミトコンドリア経路に関連した口腔癌新規治療法の開発

    武田大介, 長谷川巧実, 今井佑輔, 榊原晶子, 重田崇至, 南川勉, 渋谷恭之, 古森孝英

    第58回日本口腔外科学会総会, 2013年10月, 日本語, 日本口腔外科学会, 福岡, 国内会議

    口頭発表(一般)

  • シスプラチン併用化学放射線療法の術後補助療法としての有効性に関する検討

    重田崇至, 南川 勉, 松井太輝, 明石昌也, 長谷川巧実, 高橋佑輔, 筧 康正, 渋谷恭之, 梅田正博, 古森孝英

    第58回日本口腔外科学会総会, 2013年10月, 日本語, 日本口腔外科学会, 福岡, 国内会議

    口頭発表(一般)

  • 下顎枝垂直骨切り術術後における口腔内・口腔外知覚神経障害の経時的変化に関する検討

    浅井雅敏, 立石千鶴, 長谷川巧実, 古土井春吾, 渋谷恭之, 古森孝英

    第29回兵庫県歯科医学大会総会, 2013年08月, 日本語, 兵庫県歯科医学大会, 神戸, 国内会議

    口頭発表(一般)

  • 舌背部に生じた顆粒細胞腫の1例

    岩田英治, 長谷川巧実, 安岡大介, 高橋佑輔, 重田崇至, 南川 勉, 渋谷恭之, 古森孝英

    第44回日本口腔外科学会近畿支部学術集会, 2013年06月, 日本語, 日本口腔外科学会, 神戸, 国内会議

    口頭発表(一般)

  • 外科的矯正治療により咬合改善を得た上下顎の歯数不調和を伴う下顎骨骨折変形治癒症例

    浅井雅敏, 立石千鶴, 岡本奈那, 長谷川巧実, 筧 康正, 竹内純一郎, 鈴木泰明, 古土井春吾, 渋谷恭之, 古森孝英

    第23回日本顎変形症学会総会, 2013年06月, 日本語, 日本顎変形症学会, 大阪, 国内会議

    ポスター発表

  • 53歳下顎側方偏位症例に対し外科的矯正治療を行った1例

    塩屋園敦, 立石千鶴, 長谷川巧実, 今井佑輔, 竹内純一郎, 鈴木泰明, 古土井春吾, 渋谷恭之, 古森孝英

    第23回日本顎変形症学会総会, 2013年06月, 日本語, 日本顎変形症学会, 大阪, 国内会議

    ポスター発表

  • 放射線治療後に照射範囲外から骨移植を行ったインプラント治療の検討

    中條泰宏, 渋谷恭之, 石田 優, 長谷川巧実, 竹内純一郎, 小林正樹, 古森孝英

    第67回日本口腔科学会総会, 2013年05月, 日本語, 日本口腔科学会, 宇都宮, 国内会議

    口頭発表(一般)

  • 口腔癌患者への緩和ケアチームの介入についての臨床的検討

    米澤奈津季, 南川 勉, 高橋佑輔, 榊原晶子, 長谷川巧実, 高田直樹, 竹内純一郎, 重田崇至, 渋谷恭之, 古森孝英

    第31回日本口腔腫瘍学会総会, 2013年01月, 日本語, 日本口腔腫瘍学会, 東京, 国内会議

    口頭発表(一般)

  • 遊離腓骨皮弁移植におけるMR Angiographyと超音波検査による下肢血管解剖の術前評価

    明石 昌也, 橋川 和信, 榊原 晶子, 長谷川 巧実, 重田 崇至, 南川 勉, 古土井 春吾, 渋谷 恭之, 古森 孝英

    第57回日本口腔外科学会総会・学術大会, 2012年10月, 日本語, 日本口腔外科学会, 横浜, 国内会議

    口頭発表(一般)

  • 舌部分切除手術パス作成の取り組み

    長谷川 巧実, 李 進彰, 井堂 信二郎, 重田 崇至, 吉武 賢, 中野 沙織, 富本 貴子

    第11回日本クリニカルパス学会学術集会, 2010年12月, 日本語, 日本クリニカルパス学会, 松山, 国内会議

    口頭発表(一般)

  • 下顎骨再建に生体吸収性材料HA/PLLA複合体を使用した1例

    長谷川 巧実, 李 進彰, 後藤 育子, 吉武 賢, 中野 沙織, 古森 孝英

    第14回日本顎顔面インプラント学会総会, 2010年12月, 日本語, 日本顎顔面インプラント学会, 千葉, 国内会議

    口頭発表(一般)

  • 抗血栓療法患者の歯科処置における止血困難症例の3症例

    中野 沙織, 李 進彰, 井堂 信二郎, 重田 崇至, 長谷川 巧実, 梅田 正博, 古森 孝英

    第27回日本障害者歯科学会総会, 2010年10月, 日本語, 日本障害者歯科学会, 東京, 国内会議

    口頭発表(一般)

  • NBI,ルゴール染色の併用により早期に発見し得た舌表在癌の検討.

    長谷川巧実, 李 進彰, 井堂信二郎, 重田崇至, 吉武 賢, 中野沙織, 梅田正博, 古森孝英

    第55回日本口腔外科学会総会, 2010年10月, 日本語, 日本口腔外科学会, 千葉, 国内会議

    口頭発表(一般)

  • 下顎骨腫瘍

    大林 真理子, 小川 郁子, 李 進彰, 井堂 信二郎, 重田 崇至, 長谷川 巧実, 中野 沙織, 横崎 宏, 宮内 睦美, 高田 隆

    第102回日本病理学会中国四国支部学術集会, 2010年07月, 日本語, 日本病理学会, 米子, 国内会議

    口頭発表(一般)

  • 抗凝固薬継続下で歯科観血的処置を行った256例の検討-後出血の頻度と対策について

    吉武 賢, 梅田 正博, 村田 真穂, 長谷川 巧実, 重田 崇至, 井堂 信二郎, 李 進彰, 古森 孝英

    第64回日本口腔科学会総会, 2010年06月, 日本語, 日本口腔科学会, 札幌, 国内会議

    口頭発表(一般)

  • 口腔外科手術時の開放創に対するPGAシートおよびフィブリン糊スプレーの使用経験(第2報) 早期脱落の原因と対処法

    村田 真穂, 梅田 正博, 竹内 純一郎, 鈴木 泰明, 古森 孝英, 長谷川 巧実, 井堂 信二郎, 李 進彰

    第64回日本口腔科学会総会, 2010年06月, 日本語, 日本口腔科学会, 札幌, 国内会議

    [招待有り]

    口頭発表(招待・特別)

  • 下顎知歯抜歯後の下唇知覚鈍麻と術前のパノラマX線および多断面再構成CT画像所見との関係

    長谷川 巧実, 李 進彰, 梅田 正博, 有馬 宏美, 高橋 英哲, 重田 崇至, 井堂 信二郎, 古森 孝英

    第64回日本口腔科学会総会, 2010年06月, 日本語, 日本口腔科学会, 札幌, 国内会議

    口頭発表(一般)

  • 抗血栓療法継続下での歯科観血的処置後の出血の現状と対策

    重田崇至, 李 進彰, 長谷川巧実, 井堂信二郎, 梅田正博, 村田真穂, 南川 勉, 古土井春吾, 渋谷恭之, 古森孝英

    2010年04月, 日本語, 第19回日本有病者歯科医療学会, 神戸, 国内会議

    口頭発表(一般)

  • 口底部に発生した神経鞘腫の1例

    有馬宏美, 李 進彰, 井堂信二郎, 重田崇至, 長谷川巧実, 古森孝英

    2010年01月, 日本語, 第28回日本口腔腫瘍学会総会, 東京, 国内会議

    口頭発表(一般)

  • ヒト新鮮骨折において、低出力超音波パルス(LIPUS)は骨折血腫由来細胞の分化を促進し骨形成に作用する

    岩倉崇, 長谷川巧実, 三輪雅彦, 新倉隆宏, 酒井良忠, 大江啓介, 李相亮, 黒坂昌弘

    第35回日本骨折治療学会, 2009年07月, 日本語, 日本骨折治療学会, 横浜, 国内会議

    ポスター発表

共同研究・競争的資金等の研究課題

  • 血管・リンパ管新生に着眼した歯性感染症-顎骨骨髄炎移行メカニズム解明と治療法探索

    明石 昌也, 木本 明, 長谷川 巧実, 筧 康正

    日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C), 神戸大学, 2019年04月01日 - 2023年03月31日

  • 唾液腺癌発癌に関わる遺伝子の解析と分子標的薬の探索

    野口 一馬, 寺田 友紀, 山根木 康嗣, 柳本 惣市, 岸本 裕充, 鵜澤 成一, 中野 芳朗, 長谷川 巧実

    日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C), 兵庫医科大学, 2019年04月01日 - 2022年03月31日

  • 薬剤関連顎骨壊死の発症原因解明と発症予防法確立に向けた多施設共同前向き研究

    兒島 由佳, 岩井 大, 五月女 さき子, 長谷川 巧実, 梅田 正博, 船原 まどか

    日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C), 関西医科大学, 2019年04月01日 - 2022年03月31日

  • 口腔癌頸部リンパ節転移被膜外浸潤進展度分類と進展メカニズムの分子細胞生物学的研究

    山田 慎一, 栗田 浩, 大倉 正也, 柳本 惣市, 長谷川 巧実, 太田 嘉英, 梅田 正博, 桐田 忠昭

    日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C), 信州大学, 2018年04月01日 - 2021年03月31日

    本年度は①口腔癌の頸部リンパ節転移の被膜外浸潤症例において、われわれが設定した進展度分類(Yamada S, et al., 2015.)を行い、臨床病理学的因子、予後との相関 を検討し、予後予測因子あるいは術後補助療法適用の指標となり得るかを検討する。②それぞれの進展度分類において、被膜外浸潤最先端部の腫瘍細胞組織をマイクロダイセクション法を用いて選択的に採取し、マイクロアレイを用いて、それぞれの被膜外浸潤進展度の腫瘍細胞の遺伝子発現プロファイルを網羅的に検討し、被膜外浸潤の進展に関与する分子を同定する、ことを計画した。 口腔扁平上皮癌の頸部リンパ節転移があり、被膜外浸潤症例の集積ならびに観察項目のデータ収集を行った。被膜外浸潤症例について、われわれが設定した被膜外浸潤の進展度分類に基づいて分類を行った。また、該当症例について、パラフィンブロックより、薄切標本を作製した。被膜外浸潤および進展度分類に影響する分子について、特に今回は細胞の運動に関連するアクチン束状化タンパクであるactinin-4について免疫組織化学的染色を行い、その発現と臨床病理組織学的因子との関連について検討を行うこととした。しかしながら、リンパ節の薄切標本は比較的大きいことから、免疫組織化学的染色が困難であり、安定的に免疫組織化学的染色を行って評価可能な標本を得ることは困難であった。引き続き、免疫組織化学的染色の染色を安定的にリンパ節標本においても行えるように検討を行い、合わせてマイクロダイセクションの実施を行う。

  • 長谷川 巧実

    学術研究助成基金助成金/基盤研究(C), 2018年04月 - 2022年03月, 研究代表者

    競争的資金

  • 放射線性多発う蝕の発生機序の解明と予防法に関する多施設共同ランダム化比較試験

    五月女 さき子, 梅田 正博, 長谷川 巧実, 山田 慎一, 渋谷 恭之, 上田 順宏, 兒島 由佳, 山口 泰平

    日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C), 長崎大学, 2017年04月01日 - 2020年03月31日

    頭頸がんに対する放射線治療(RT)の重篤な晩期有害事象の一つに放射線性顎骨壊死(ORN)がある。照射方法の進歩とともにORNの発症頻度は近年では低くなってきたが、依然として10~20%程度の患者に発症し、患者のQOLを低下させる大きな原因となっている。 実際にRT前と1年後、2年後のパノラマX線写真を比較したところ、急速にう蝕が進行する患者が少なからず存在することを確認した。う蝕多発者では唾液腺だけではなく歯に対する照射線量が60Gy以上と多かったが、口腔衛生状態はう蝕が発生しなかった患者と差はなく、さらに上顎あるいは下顎のみに照射された患者では照射された顎にのみう蝕が多発することや、片側の照射例では照射された側にのみう蝕が多発することが明らかとなった。本研究は、1)RT後の多発う蝕の実態を多施設共同後ろ向き観察研究で明らかにすること、2)RT後に歯を含む歯槽部が切除された患者の切除検体を用いてRTによる歯の直接障害の有無や程度について調べること、および3)トレー法によるフッ化物局所応用によりRT後のう蝕多発が予防できるかどうかを多施設共同ランダム化比較試験により検証することを目的とするものである。そこでまずは後ろ向きに調査した。その後ろ向き研究では、口腔がん手術単独例では2年後のう蝕増加数は0.6歯であったのに対して、RT患者では4.9歯と有意に多かった。放射線性う蝕の特徴としては、①歯頸部からの発生が多い、②疼痛などの自覚症状に乏しい、③歯頸部から歯が破折して初めて発見されることも少なくない,④歯の黒変,あるいは歯冠歯質の軟化がみられることもある、⑤歯質の欠損がない、あるいはC2までの状態で歯根膜腔の拡大や根尖病巣を認めるというものであった。そこで実際に頭頸部がんRT患者10例を1年間観察したところ新たなう蝕の発生はみられなかった。

  • 放射線性顎骨壊死の病態と発症リスク因子の解明に関する多施設共同研究

    兒島 由佳, 池田 通, 五月女 さき子, 上田 順宏, 山田 慎一, 梅田 正博, 桐田 忠昭, 渋谷 恭之, 長谷川 巧実, 中村 聡明, 藤澤 琢郎

    日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C), 関西医科大学, 2016年04月01日 - 2019年03月31日

    2008年~2014年の頭頸部癌放射線治療患者392例の多施設共同研究では、放射線性顎骨壊死(ORN)の発症リスク因子として、Cox回帰分析による多変量解析で原発部位(口腔中咽頭癌)、RT時の根尖病巣(あり)、RT後の抜歯(あり)の3因子が独立した因子として同定された。ORN発症例30例の検討では下顎発症例が多く、発症契機として根尖病巣やRT後の抜歯の他、放射線誘発性う蝕が挙げられた。さらに2015年~2017年の口腔・中咽頭癌放射線治療患者132例では、2014年以前と比べてORN発症率が有意に増加していたが、その理由については不明であり、今後さらに検討したい。

  • 長谷川 巧実

    学術研究助成基金助成金/若手研究(B), 2015年04月 - 2018年03月, 研究代表者

    競争的資金

  • 長谷川 巧実

    科学研究費補助金/若手研究(B), 2012年04月 - 2015年03月, 研究代表者

    競争的資金