研究者紹介システム

上田 香織
ウエダ カオリ
医学部附属病院 眼科
助教
医学
Last Updated :2021/06/11

研究者情報

所属

  • 【主配置】

    医学部附属病院 眼科
  • 【配置】

    大学院医学研究科 医科学専攻

学位

  • 博士(医学), 神戸大学

研究ニュース

研究活動

研究分野

  • ライフサイエンス / 眼科学

受賞

  • 2018年12月 日本神経眼科学会, 日本神経眼科学会学術賞, Nationwide epidemiological survey of Leber hereditary optic neuropathy in Japan.

    上田香織

    学会誌・学術雑誌による顕彰

  • 2018年10月 日本ジェネティクス株式会社, ジェネ・グラント2018審査員特別賞, レーベル遺伝性視神経症の治療と発症予防を目標とした病態研究

    上田香織

    その他の賞

論文

  • Kaori Ueda, Akiko Miki, Shunichiro Nakai, Suiho Yanagisawa, Koji Nomura, Makoto Nakamura

    PURPOSE: To retrospectively investigate the sensitivity and specificity of weight gain, insulin-like growth factor 1, and neonatal retinopathy of prematurity (WINROP) algorithm for the prediction of severe retinopathy of prematurity (ROP) in a Japanese population of preterm infants. The WINROP algorithm is a tool based on postnatal weight gain. STUDY DESIGN: Retrospective cohort study. METHODS: The medical records of preterm infants born between January 2011 and March 2017 were retrospectively reviewed. Infants born after 33 weeks of gestation were excluded based on the indications of the WINROP algorithm. Postnatal weight was recorded weekly on the WINROP system until postmenstrual week 36. The sensitivity and specificity of the WINROP algorithm were analyzed. RESULTS: In total, 278 infants were included in this study. Based on the WINROP algorithm 110 of these infants were predicted to be at low risk for developing severe ROP and 105 did not develop severe ROP. Based on the WINROP algorithm 168 infants were predicted to be at high risk for developing severe ROP and 27 developed severe ROP. Thus, the sensitivity of the WINROP algorithm was 84.4% and the specificity 42.7%. CONCLUSION: The WINROP algorithm could be used for preterm infants (gestational age of <28 weeks) without a complicated hospital course. Modification of the algorithm will improve its sensitivity and specificity for the Japanese population.

    2020年03月, Japanese journal of ophthalmology, 64 (2), 223 - 227, 英語, 国内誌

    [査読有り]

  • Sotaro Mori, Yusuke Murai, Kaori Ueda, Mari Sakamoto, Takuji Kurimoto, Yuko Yamada-Nakanishi, Makoto Nakamura

    Objective: To compare the 1-year outcomes of trabeculotomy ab externo (ab externo TLO) and trabeculotomy ab interno using a microhook (ab interno TLO) for glaucoma patients using propensity score analysis. Methods and analysis: The medical charts of 65 consecutive patients who underwent ab externo TLO and those of 69 patients who underwent ab interno TLO were reviewed. Logistic regression analysis was conducted to calculate the propensity score using 1:1 matched analysis, which indicates the likelihood of surgical success at 12 months. We set the outcome-related covariates as age, glaucoma type, mean deviation, preoperative intraocular pressure (IOP), the number of preoperative glaucoma eye drops and the presence or absence of combined cataract surgery. Fifty eyes per each surgery group were subsequently compared. Results: The mean preoperative IOP was 32.5±11.2 mm Hg in the ab externo TLO group and 28.4±7.8 mm Hg in the ab interno TLO group (p=0.08). The mean postoperative IOP at 12 months was 18.3±7.4 mm Hg in the former group and 17.8±6.3 mm Hg in the latter (p=0.91). When surgical success was defined as a postoperative IOP of between 5 and 21 mm Hg with a more than 20% IOP reduction from baseline and no additional glaucoma surgery, the rate at 12 months was 78% in the ab externo TLO group and 74% in the ab interno TLO group (p=1.00). Conclusion: The 1-year success rate was not significantly different between ab externo and ab interno TLO.

    2020年, BMJ open ophthalmology, 5 (1), e000446, 英語, 国際誌

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  • A Case of multi-system langerhans cell histiocytosis with local invasion of the orbital apex.

    Hirko Yamada H, Takuji Kurimoto, Sotarou Mori, Mari Sakamoto, Kaori Ueda, Yuko Yamada-Nakanishi, Uozumi Y, Shose H, Taniguchi M, Toyoda M, Minami H, Makoto Nakamura

    2019年09月, Case Reports in Ophthalmology, 10 (3), 319 - 326, 英語, 国際誌

    [査読有り]

    研究論文(学術雑誌)

  • Mari Sakamoto, Sotaro Mori, Kaori Ueda, Takuji Kurimoto, Sentaro Kusuhara, Yuko Yamada-Nakanishi, Makoto Nakamura

    Purpose: The present study aimed to assess the ability of en face slab images of maculae to detect residual nerve fiber bundles in eyes with advanced glaucoma. Methods: This study included 36 eyes with diffuse thinning of the ganglion cell and inner plexiform layers (GCL+IPL). Inclusion criterion was GCL+IPL thickness of <1% of the normative database level as detected using optical coherence tomography (OCT). En face slab images (50-μm thickness) were reconstructed from the macular cube scan data using advanced visualization settings. Thereafter, we assessed the agreement of the locations between hyperreflective nerve fiber bundles and normal points in the Humphrey visual field test 10-2 pattern deviation (PD) plots. Additionally, total deviation (TD) corresponding to hyperreflective and hyporeflective areas was compared. Results: Hyperreflective areas were detected in 31 out of 36 eyes; all 31 eyes exhibited at least one normal PD point despite the substantial GCL+IPL thinning in the macular region. Two eyes with abnormalities in all PD points showed no hyperreflective area. The remaining three eyes had normal PD points despite the lack of high reflectivity areas in the slab images. Therefore, 91.7% of eyes showed agreement between en face slab images and PD plots. Moreover, hyperreflective areas demonstrated significantly better TD than hyporeflective areas. Conclusions: En face slab images of maculae were able to reveal the residual nerve fiber bundles in the eyes with advanced glaucoma despite the GCL+IPL thickness in the maculae being diffusely and substantially reduced.

    2019年07月01日, Investigative ophthalmology & visual science, 60 (8), 2811 - 2821, 英語, 国際誌

    [査読有り]

  • Sotaro Mori, Takuji Kurimoto, Akiyasu Kanamori, Mari Sakamoto, Kaori Ueda, Yuko Yamada-Nakanishi, Makoto Nakamura

    Purpose: The purpose of this study was to evaluate the concordance of a temporal raphe architecture estimated using optical coherence tomography (OCT) and MP-3 microperimetry. Methods: We enrolled 25 eyes with either an upper or lower glaucomatous hemifield defect, as detected on the Humphrey visual field 30-2 test. A structural temporal raphe was extrapolated from visible end points of retinal nerve fiber bundles present in a perimetrically normal hemiretina on an en face Spectralis OCT image. A functional temporal raphe was drawn as a line from the fovea to the border of at least a 10-dB difference in sensitivity, at vertically adjacent test points, with at least three consecutive pairs among 25 test points placed at 8° to 18° from the fovea (2° intervals) on the MP-3. An angle determined by the optic disc center, the fovea, and the temporal raphe line (the DFR angle) was calculated. Correlations and agreement of the OCT- and MP-3-derived DFR angles and factors affecting discordance of the two estimates were evaluated. Results: Despite no significant demographic differences, the functional DFR angle (mean ± SD, 171.8° ± 3.5°) was significantly larger than that of the structural DFR angle (166.5° ± 3.2°) in 14 eyes with upper hemifield defects and vice versa in 11 eyes with lower hemifield defects (163.4° ± 3.0° vs. 170.5° ± 3.2°). The mean deviation was significantly associated with the functional and structural DFR angle difference in eyes with only upper hemifield defects. Conclusions: The structural temporal raphe was more deviated to the perimetrically normal hemiretina side than to the functional temporal raphe, thereby suggesting that a structural change may precede a functional loss.

    2019年04月01日, Investigative ophthalmology & visual science, 60 (5), 1403 - 1411, 英語, 国際誌

    [査読有り]

  • Takuji Kurimoto, Kaori Ueda, Sotaro Mori, Mari Sakamoto, Yuko Yamada-Nakanishi, Wataru Matsumiya, Makoto Nakamura

    Background: Leber hereditary optic neuropathy (LHON) is a maternally inherited disease caused by three missense mutations of mitochondrial (mt) DNA, ie, m 3460 G>A, m 11778 G>A, or m 14484 T>C in the greater portion of LHON. m 11778 G>A mutation is especially observed in >90% of the cases in Japanese families. Although spontaneous remission of visual function infrequently occurs, effective treatment for LHON remains unestablished. Transcorneal electrical stimulation has been shown to be efficacious in individuals with optic neuropathy. However, due to potential risk of corneal damage, repeated treatments are not permissible. In this exploratory study, we will be conducting skin electrical stimulation (SES) as an intervention for patients with LHON having 11778 missense mutation and investigate effectiveness and safety of SES. Methods: This is a single-arm, prospective, open-label exploratory trial focused on patients with LHON having 11778 missense mutation. Eleven patients will be enrolled and receive six consecutive SES once every 2 weeks up to 10 weeks. The safety of the SES will be monitored with specular microscopy, slit-lamp biomicroscopy, fundus examinations, and the observation of facial skin. The primary outcome measure will be the averaged l ogarithm of minimum angle resolution (logMAR) converted visual acuity 1 week after the last SES. Secondary outcome measures include changes, in logMAR at 4 and 8 weeks after the last SES, such as visual field indices measured using Humphrey visual field and microperimetry-3, the thickness of peripapillary retinal fiber and macular ganglion cell complex, multifocal visual evoked potentials, critical flicker frequency, and color vision. Discussion: The results of this proposed proof-of-concept feasibility trial will help plan and execute a larger definitive trial to test SES as an effective strategy for LHON and related optic neuropathies and help establish a beneficial treatment for LHON.

    2019年, Clinical ophthalmology (Auckland, N.Z.), 13, 897 - 904, 英語, 国際誌

    [査読有り]

  • The Difficulty of Diagnosing Invasive Aspergillosis Initially Manifesting as Optic Neuropathy

    Mori S, Kurimoto T, Kawara K, Ueda K, Sakamoto M, Keshi Y, Yamada-Nakanishi Y, Tachibana H, Nakamura M

    2019年01月, Case Rep Ophthalmol, 10 (1), 11 - 18, 英語

    [査読有り]

    研究論文(学術雑誌)

  • 髄膜炎を伴う続発性眼窩炎症と強膜炎を呈した汎発性帯状疱疹の1例

    佐々木 信之, 坂本 麻里, 栗本 拓治, 盛 崇太郎, 上田 香織, 中西 裕子, 飯島 健太, 立花 久嗣, 中村 誠

    日本神経眼科学会, 2018年11月, 神経眼科, 35 (増補1), 87 - 87, 日本語

    [査読有り]

  • Effectiveness and safety of sulcus fixation of Baerveldt glaucoma implants in glaucomatous eyes in patients who underwent multiple intraocular surgeries

    Mori S, Sakamoto M, Kurimoto T, Kanamori A, Ueda K, Inoue Y, Yamada Y, Nakamura M

    2018年10月, Graefes Arch Clin Exp Ophthalmol, 256 (10), 1953 - 1960, 英語

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    研究論文(学術雑誌)

  • レーベル遺伝性視神経症における視標サイズに基づく中心暗点の評価

    上田香織, 盛崇太朗, 坂本麻里, 芥子結香子, 栗本拓治, 山田裕子, 中村誠

    2018年09月, 神経眼科, 35 (3号), 303 - 308, 日本語

    [査読有り]

    研究論文(学術雑誌)

  • Vasculitis with superior ophthalmic vein thrombosis compatible with neuro-neutrophilic disease

    Sakamoto M, Kurimoto T, Mori S, Ueda K, Keshi Y, Yamada Y, Azumi A, Shimono T, Nakamura M

    2018年08月, Am J Ophthalmol Case Rep, 12, 39 - 44, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Sotaro Mori, Takuji Kurimoto, Kaori Ueda, Makoto Nakamura

    Purpose: To evaluate temporal changes in visual acuity in patients with steroid-resistant optic neuritis (ON) in neuromyelitis optica spectrum disorders (NMOSD) after apheresis. Design: Retrospective observational study, clinical case series Subjects and methods: We reviewed the medical charts of 15 eyes of 9 consecutive patients with ON in NMOSD who underwent apheresis between March 2010 and September 2017. All patients were seropositive for anti-aquaporin 4 (AQP4) antibody and resistant to steroid pulse therapy. Apheresis was performed by either simple plasma exchange or/and immune adsorption therapy. Results: Twelve eyes (80%) showed improvement with logMAR > 0.3 at 1 month after apheresis. Within 1 month after apheresis therapy, logMAR on average significantly decreased, the magnitude of change being greatest within the first week. Thereafter visual acuity became stable in 10 of the 11 eyes, until 12 months. However, two eyes (12%) showed recurrence of visual acuity reduction 3 months after the cessation of apheresis. There were a few serious complications during and after apheresis, but these were completely treatable. Conclusions: Additional apheresis therapy rapidly improves the visual acuity of steroid-resistant seropositive AQP4 ON.

    Springer Tokyo, 2018年07月01日, Japanese Journal of Ophthalmology, 62 (4), 525 - 530, 英語

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    研究論文(学術雑誌)

  • Optic Neuritis Possibly Induced by Anti-PD-L1 Antibody Treatment in a Patient with Non-Small Cell Lung Carcinoma

    Mori S, Kurimoto T, Ueda K, Enomoto H, Sakamoto M, Keshi Y, Yamada Y, Nakamura M

    2018年07月, Case Rep Ophthalmol, 9 (2), 348 - 356, 英語

    [査読有り]

    研究論文(学術雑誌)

  • 日本の未熟児におけるWINROPアルゴリズムの感度と特異度の検討

    上田 香織, 三木 明子, 中井 駿一朗, 中村 賢和, 安武 博樹, 柳沢 翠芳, 野村 耕治, 中村 誠

    (公財)日本眼科学会, 2018年03月, 日本眼科学会雑誌, 122 (臨増), 307 - 307, 日本語

    [査読有り]

  • Mari Sakamoto, Yoshiko Matsumoto, Sotaro Mori, Kaori Ueda, Yukako Inoue, Takuji Kurimoto, Akiyasu Kanamori, Yuko Yamada, Makoto Nakamura

    Purpose: We previously reported that eyes with hypotony maculopathy (HM) after trabeculectomy (TLE) exhibited more reduction of axial length (AL) than those without HM, suggesting that inward collapse of the scleral wall may contribute to the development of HM after TLE. However, we did not evaluate change in choroidal thickness (CT), which could influence AL measures. We compared the magnitude and rate of AL and CT changes in eyes with and without HM by simultaneously measuring these parameters before and after TLE. Methods We enrolled 77 eyes of 77consecutive patients with glaucoma, who underwent TLE between March 2014 and March 2016. Intraocular pressure (IOP), central corneal thickness, keratometry, AL, and CT were measured pre- and postoperatively, up to 6 months. These biometrics were compared in eyes with and without HM. Results The 14 patients who developed HM were significantly younger than those who did not. The eyes with HM exhibited significantly reduced AL (2.8%) compared to those without HM (0.7%). There was no significant difference in CT change between the two groups. The rate of AL reduction was significantly correlated with age, postoperative IOP, and preoperative AL. Post-adjustment logistic regression analysis revealed that eyes with AL reduction rate 2% had 11.67 higher risk for developing HM (95% confidence interval, 1.28–106.6 P = 0.03). Conclusions AL reduction rates 2% were significantly associated with HM. Excessive reduction in AL, which was seen in eyes with HM, was not an artificial measure resulting from choroidal thickening but rather reflected reductions in the anterior-posterior diameter of the eyeball. Inward collapse of the scleral wall leads to redundancy of the chorioretinal tissue, contributing to the development of HM after TLE.

    Public Library of Science, 2018年01月01日, PLoS ONE, 13 (1), 英語

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    研究論文(学術雑誌)

  • Mari Sakamoto, Sotaro Mori, Kaori Ueda, Azusa Akashi, Yukako Inoue, Takuji Kurimoto, Akiyasu Kanamori, Yuko Yamada, Makoto Nakamura

    Purpose: To assess the combined estimate of retinal ganglion cell (RGC) count developed by Medeiros et al. as a tool for diagnosis of glaucoma in Japanese patients. Study design: Cross-sectional study. Methods: Thirty-one eyes of 19 healthy controls and 106 eyes of 70 glaucoma patients underwent standard automated perimetry (SAP) and three types of spectral domain optical coherence tomography (SD-OCT) imaging using the Cirrus, RTVue, and 3D-OCT instruments. RGC counts derived from SAP and SD-OCT data were estimated using the Harwerth model (SAPrgc and OCTrgc, respectively), from which the combined RGC count estimates (CRGC) were calculated using the formula developed by Medeiros et al. Receiver operating characteristic curve (ROC) analyses were conducted for mean deviation (MD), retinal nerve fiber layer thickness (RNFLT), and CRGC. Results: The mean OCTrgc derived from the Cirrus, RTVue, and 3D-OCT instruments were 1150, 1245, and 1316 (× 1000 cells), respectively, for the control group and 463, 519, and 516 (× 1000 cells), respectively, for the patient group. SAPrgc of the controls’ group was 1526 and the patients’ group, 731 (× 1000 cells), and were consistently greater than OCTrgc in both groups (a generalized estimating equation model, p <  0.001). Partial area under the curve (pAUC) of MD was 0.178, and that of RNFLT and CRGC for the three OCT instruments were 0.185, 0.18, 0.189 and 0.196, 0.196, 0.197, respectively. CRGC had larger pAUC than MD, whereas there was no or marginal difference in pAUC between CRGC and cpRNFLT, irrespective of OCT device used or glaucoma severity. Conclusion: CRGC proved well suited to discriminate glaucoma patients from controls. However, its clinical utility did not seem to overwhelm isolated structural measures in the tested Japanese patients.

    Springer Tokyo, 2018年01月01日, Japanese Journal of Ophthalmology, 62 (1), 31 - 40, 英語

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    研究論文(学術雑誌)

  • Kaori Ueda, Yuki Morizane, Fumio Shiraga, Keigo Shikishima, Hitoshi Ishikawa, Masato Wakakura, Makoto Nakamura

    Background: Leber hereditary optic neuropathy (LHON) is a maternally inherited optic neuropathy that leads to central loss of vision, predominantly in young males. Most LHON cases have one of three primary point mutations in mitochondrial DNA (mtDNA). The annual incidence and prevalence of LHON in Japan are not known. Thus, we estimated the annual incidence of molecularly confirmed LHON in Japan during 2014. Methods: Sequential questionnaires were sent to 1397 facilities, which included all of the university hospitals in Japan, and they were certified by either the Japanese Ophthalmological Society or the Japanese Neuro-Ophthalmological Society. We calculated the incidence number (Ir) as the number of patients who developed LHON in 2014 and its 95% confidence interval. Results: We received 861 responses to the first questionnaire, where 49 facilities reported 72 cases (67 were male and 5 were female) of newly developed LHON during 2014. Ir was calculated as 117, and the 95% confidence interval ranged from 81 to 153. For the second questionnaire, responses were received from 30 facilities, where the median age at onset was 38 years for males and 30 years for females, and 86.5% of cases possessed the mtDNA ND4/G11778A mutation. Conclusion: Approximately 120 cases of newly developed LHON were reported during 2014 in Japan, and 93.2% were males. (C) 2017 The Authors. Publishing services by Elsevier B.V. on behalf of The Japan Epidemiological Association.

    ELSEVIER SCIENCE INC, 2017年09月, JOURNAL OF EPIDEMIOLOGY, 27 (9), 447 - 450, 英語

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    研究論文(学術雑誌)

  • Icare HOMEを用いた眼圧のホームモニタリングおよび日内変動の検討

    坂本麻里, 金森章泰, 盛崇太郎, 上田香織, 井上結香子, 栗本拓治, 山田裕子, 中村誠

    2017年04月, 日本眼科学会雑誌, 121 (4号), 366 - 372, 日本語

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    研究論文(学術雑誌)

  • Yoshiko Matsumoto, Sotaro Mori, Kaori Ueda, Takuji Kurimoto, Akiyasu Kanamori, Yuko Yamada, Ichiro Nakashima, Makoto Nakamura

    Purpose An autoantibody against aquaporin-4 (AQP4 Ab) is highly specific for neuromyelitis optica spectrum disorder and plays a pathogenic role in this disease. The purpose of this study was to investigate the impact of AQP4 Ab on inner retinal structure, function, and the structure -function relationships in eyes with optic neuritis. Methods Thirty five eyes from 25 cases who had received visual function tests and RTVue optical coherence tomography (OCT) measurement at least six months after the latest episode of optic neuritis were enrolled. Patients with multiple sclerosis were excluded. AQP4 Ab was measured using a cell -based assay. Visual acuity, mean deviation (MD) of the Humphrey visual field SITA standard 30-2 tests, retinal nerve fiber layer (RNFL), ganglion cell complex (GCC) thicknesses, and other clinical variables were compared between the AQP4 Ab-positive and-negative groups. Parameters associated with visual functions were evaluated by generalized estimating equation (GEE) models. Results The AQP4 Ab-positive group (20 eyes from 12 cases) had a higher proportion of bilateral involvement and longer duration of follow-up than the AQP4 Ab-negative group (15 eyes from 13 cases). Linear mixed effect models revealed worse MD and visual acuity in AQP4 Ab-positive eyes than those in AQP4 Ab-negative eyes after adjusting for within -patient inter-eye dependence, whereas there were no differences in RNFL and GCC thickness between the two groups. In seropositive eyes, GEE regression analyses revealed that depending on age and the number of recurrences of ON episodes, OCT parameters correlated strongly with MD and more weakly with visual acuity. Conclusions Reductions in RNFL and GCC thickness were proportional to the visual field defect in eyes with AQP4 Ab but not in eyes without AQP4 Ab. The presence of AQP4 Ab probably plays a critical role in retinal ganglion cell loss in optic neuritis.

    PUBLIC LIBRARY SCIENCE, 2017年02月, PLOS ONE, 12 (2), e0171880, 英語

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    研究論文(学術雑誌)

  • 抗AQP4抗体陽性視神経炎に対する血液浄化療法の治療効果

    盛 崇太朗, 栗本 拓治, 坂本 麻里, 上田 香織, 井上 結香子, 千原 典夫, 金森 章泰, 山田 裕子, 中村 誠

    日本神経眼科学会, 2016年10月, 神経眼科, 33 (増補1), 86 - 86, 日本語

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  • Schlemm管内皮網除去と深層強膜弁切除を併施した線維柱帯切開術の術後成績

    安田絵里子, 金森章泰, 上田香織, 明石梓, 坂本麻里, 井上結香子, 山田裕子, 中村誠

    2016年09月, 日本眼科学会雑誌, 120 (9号), 635 - 639, 日本語

    [査読有り]

    研究論文(学術雑誌)

  • Azusa Akashi, Akiyasu Kanamori, Kaori Ueda, Yukako Inoue, Yuko Yamada, Makoto Nakamura

    PURPOSE. Optical coherence tomography (OCT) instruments do not embed a normative database from highly myopic normal (HMN) eyes. The abilities of three OCT instruments to detect early glaucoma with high myopia were compared using the two controls with or without high myopia. METHODS. A total of 52 early glaucomatous eyes (mean deviation > -6.0 dB) with high myopia (spherical equivalent <= -6.0 diopters [HMG]), 54 HMN eyes, and 90 nonhighly myopic normal (NHMN) eyes were enrolled. Each participant was imaged using Cirrus, RTVue, and Topcon 3D OCT to evaluate the thicknesses of the circumpapillary retinal nerve fiber layer (cpRNFL), the macular retinal nerve fiber layer (mRNFL), ganglion cell layer + inner plexiform layer (GCL/IPL), and mRNFL + GCL/IPL (GCC). The covariate-adjusted areas under the receiver operating characteristic curves (AUCs) for detecting HMG were compared among the instruments and between the two normal groups (HMN or NHMN). RESULTS. Highly myopic normal eyes showed higher AUCs for the temporal quadrant cpRNFL thickness but lower AUCs for the superior and inferior RNFL thicknesses compared with NHMN. We found the AUCs for the GCC thickness showed no significant difference between the two control groups, but the GCL/IPL and mRNFL thicknesses had differences. CONCLUSIONS. The abilities of the three OCT instruments to detect early glaucomatous eyes with high myopia were different if the normal eyes were associated with high myopia or not. A normative database that includes data from patients with high myopia should be established for accurate diagnosis of glaucoma with high myopia. (www.umin.ac.jp/ctr number, UMIN000006900.)

    ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2015年10月, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 56 (11), 6573 - 6580, 英語

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    研究論文(学術雑誌)

  • Kaori Ueda, Akiyasu Kanamori, Azusa Akashi, Yoshiko Matsumoto, Yuko Yamada, Makoto Nakamura

    Background/aims Chiasmal compression affects the crossed nerve fibres originating from the nasal hemiretina, as opposed to the uncrossed fibres from the temporal hemiretina. The objectives were to evaluate circumpapillary retinal nerve fibre layer (cpRNFL) thickness by spectral-domain optical coherence tomography in eyes with band atrophy (BA) accompanying temporal hemianopia due to chiasmal damage and to estimate the distribution pattern of cpRNFL from the nasal hemiretina. Methods This cross-sectional study included 53 eyes with optic neuropathy due to chiasmal lesions and 72 normal eyes. Visual field sensitivity (VFS) was evaluated by standard automated perimetry. Eyes with abnormalities in the nasal visual hemifield were excluded. The structure-function relationships (cpRNFL thickness and VFS in the temporal hemifield) were evaluated in eyes with BA. The base levels composed of only non-neuronal elements and cpRNFL from the temporal hemiretina were estimated in the average and 12 sector-cpRNFL thicknesses using regression analysis. Results The base level in the average cpRNFL thickness was 71.2 mm in eyes with BA, which corresponded to 70% of average thickness of normal controls. However, the estimated base level of 12 sector-cpRNFL thicknesses represented the unique distribution pattern, in which base level-thickness localised at the 1 o'clock and 5 o'clock sectors was extensively reduced, with an even distribution of base levels at other sectors. Conclusions The RNFL originating from the nasal hemiretina is estimated to enter into the optic disc predominantly at the 1 o'clock and 5 o'clock angles.

    BMJ PUBLISHING GROUP, 2015年10月, BRITISH JOURNAL OF OPHTHALMOLOGY, 99 (10), 1419 - 1423, 英語

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    研究論文(学術雑誌)

  • Kaori Ueda, Wataru Matsumiya, Keiko Otsuka, Yoshifumi Maeda, Takayuki Nagai, Makoto Nakamura

    Background: Rebamipide with mucin secretagogue activity was recently approved for the treatment of dry eye. The efficacy and safety in the treatment of rebamipide were shown in two pivotal clinical trials. It was the aim of this study to evaluate the effect of 2 % rebamipide ophthalmic suspension in patients with dry eye and analyze relevant factors for favorable effects of rebamipide in clinical practice. Methods: This was a retrospective cohort study of 48 eyes from 24 patients with dry eye treated with 2 % rebamipide ophthalmic suspension. Dry eye-related symptom score, tear film break-up time (TBUT), fluorescein ocular surface staining score (FOS) and the Schirmer test were used to collect the data from patients at baseline, and at 2, 4, 8, and 12 week visits. To determine the relevant factors, multiple regression analyses were then performed. Results: Mean dry eye-related symptom score showed a significant improvement from the baseline (14.5 points) at 2, 4, 8 and 12 weeks (9.80, 7.04, 7.04 and 7.83 points, corrected P value <0.001, respectively). Median FOS showed a significant improvement from the baseline (3.0 points) at 2, 4, 8 and 12 weeks (2.0, 2.0, 1.0 and 1.0 points, corrected P value <0.001, respectively). TBUT and Schirmer test values were not significantly improved after the treatment. For ocular symptoms, three parameters (foreign body sensation, dry eye sensation and ocular discomfort) showed significant improvements at all visits. The multiple regression analyses showed that the fluorescein conjunctiva staining score was significantly correlated with the changes of dry eye-related symptom score at 12 weeks (P value = 0.017) and dry eye-related symptom score was significantly correlated with independent variables for the changes of FOS at 12 weeks (P value = 0.0097). Conclusions: Two percent rebamipide ophthalmic suspension was an effective therapy for dry eye patients. Moreover the fluorescein conjunctiva staining score and dry eye-related symptom score might be good relevant factors for favorable effects of rebamipide.

    BIOMED CENTRAL LTD, 2015年06月, BMC OPHTHALMOLOGY, 15, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Effects of Axial Length and Age on Circumpapillary Retinal Nerve Fiber Layer and Inner Macular Parameters Measured by 3 Types of SD-OCT Instruments

    Ueda K, Kanamori A, Akashi A, Tomioka M, Kawaka Y, Nakamura M

    2015年01月, J Glaucoma, 英語

    [査読有り]

    研究論文(学術雑誌)

  • Difference in correspondence between visual field defect and inner macular layer thickness measured using three types of spectral-domain OCT instruments

    Ueda K, Kanamori A, Akashi A, Kawaka Y, Yamada Y, Nakamura M

    2015年01月, Jpn J Ophthalmol, 59 (1), 55 - 64, 英語

    [査読有り]

    研究論文(大学,研究機関等紀要)

  • The detection of macular analysis by SD-OCT for optic chiasmal compression neuropathy and nasotemporal overlap

    Akashi A, Kanamori A, Ueda K, Matsumoto Y, Yamada Y, Nakamura M

    2014年07月, Invest Ophthalmol Vis Sci, 55 (7), 4667 - 72, 英語

    [査読有り]

    研究論文(学術雑誌)

MISC

  • ランゲルハンス細胞組織球症による視神経症と外転神経麻痺を来した1例

    山田 裕子, 栗本 拓治, 盛 崇太朗, 坂本 麻里, 上田 香織, 中井 友昭, 魚住 洋一, 豊田 晶徳, 中西 裕子, 中村 誠

    日本神経眼科学会, 2018年11月, 神経眼科, 35 (増補1), 84 - 84, 日本語

  • 【視神経炎最前線】 レーベル遺伝性視神経症のイデベノン療法と遺伝子治療

    上田香織, 中村誠

    2017年11月, 臨床眼科, 71 (12号), 1666 - 1670, 日本語

    [招待有り]

    記事・総説・解説・論説等(学術雑誌)

  • 【難治性視神経症の診断・治療に対する最近の考え方】 我が国におけるレーベル遺伝性視神経症の認定基準と全国疫学調査

    中村誠, 上田香織

    2017年09月, 神経眼科, 34 (3号), 293 - 299, 日本語

    [招待有り]

    記事・総説・解説・論説等(学術雑誌)

  • The Ability of SD-OCT to Differentiate Early Glaucoma in Highly Myopia from Highly Myopic Control

    Akiyasu Kanamori, Azusa Akashi, Kaori Ueda, Mari Sakamoto, Yukako Inoue, Yuko Yamada, Makoto Nakamura

    ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2015年06月, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 56 (7), 英語

    研究発表ペーパー・要旨(国際会議)

  • Trabeculotomy with Schlemm's canal endothelium removal and deep sclerectomy

    Eriko Yasuda, Akiyasu Kanamori, Kaori Ueda, Azusa Akashi, Yukako Inoue, Yuko Yamada, Makoto Nakamura

    ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2015年06月, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 56 (7), 英語

    研究発表ペーパー・要旨(国際会議)

共同研究・競争的資金等の研究課題