Directory of Researchers

NAKANISHI Yuko
Graduate School of Medicine / Faculty of Medical Sciences
Associate Professor
Medicine
Last Updated :2021/05/12

Researcher Profile and Settings

Affiliation

  • <Faculty / Graduate School / Others>

    Graduate School of Medicine / Faculty of Medical Sciences
  • <Related Faculty / Graduate School / Others>

    School of Medicine / Faculty of Medicine, University Hospital / Ophthalmology

Research Activities

Research Areas

  • Life sciences / Ophthalmology

Awards

  • 1999 日本弱視斜視学会, 廣石賞, Differential expression of immediate-early genes, c-fos and zif268, in the visual cortex of young rats: effects of a noradrenergic neurotoxin on their expression. Yamada Y, Hada Y, Imamura K, Mataga N, Watanabe Y, Yamamoto M. Neuroscience. 1999;92

    Yamada Yuko

    Japan society

Published Papers

  • 上皮増殖因子受容体チロシンキナーゼ阻害薬が原因と考えられる眼障害の検討

    曽谷 尭之, 山田 裕子, 鉄本 章, 盛 崇太朗, 坂本 麻里, 長井 隆行, 中村 誠

    (公財)日本眼科学会, Mar. 2020, 日本眼科学会雑誌, 124 (臨増), 292 - 292, Japanese

    [Refereed]

  • Sotaro Mori, Yusuke Murai, Kaori Ueda, Mari Sakamoto, Takuji Kurimoto, Yuko Yamada-Nakanishi, Makoto Nakamura

    Objective: To compare the 1-year outcomes of trabeculotomy ab externo (ab externo TLO) and trabeculotomy ab interno using a microhook (ab interno TLO) for glaucoma patients using propensity score analysis. Methods and analysis: The medical charts of 65 consecutive patients who underwent ab externo TLO and those of 69 patients who underwent ab interno TLO were reviewed. Logistic regression analysis was conducted to calculate the propensity score using 1:1 matched analysis, which indicates the likelihood of surgical success at 12 months. We set the outcome-related covariates as age, glaucoma type, mean deviation, preoperative intraocular pressure (IOP), the number of preoperative glaucoma eye drops and the presence or absence of combined cataract surgery. Fifty eyes per each surgery group were subsequently compared. Results: The mean preoperative IOP was 32.5±11.2 mm Hg in the ab externo TLO group and 28.4±7.8 mm Hg in the ab interno TLO group (p=0.08). The mean postoperative IOP at 12 months was 18.3±7.4 mm Hg in the former group and 17.8±6.3 mm Hg in the latter (p=0.91). When surgical success was defined as a postoperative IOP of between 5 and 21 mm Hg with a more than 20% IOP reduction from baseline and no additional glaucoma surgery, the rate at 12 months was 78% in the ab externo TLO group and 74% in the ab interno TLO group (p=1.00). Conclusion: The 1-year success rate was not significantly different between ab externo and ab interno TLO.

    2020, BMJ open ophthalmology, 5 (1), e000446, English, International magazine

    [Refereed]

  • 動眼・滑車・外転神経麻痺

    中西(山田)裕子

    Oct. 2019, 臨床眼科 増刊号 実戦 メディカル眼科治療アップデート, 73 (11), 217 - 223, Japanese

    [Refereed]

    Scientific journal

  • Mari Sakamoto, Sotaro Mori, Kaori Ueda, Takuji Kurimoto, Sentaro Kusuhara, Yuko Yamada-Nakanishi, Makoto Nakamura

    Purpose: The present study aimed to assess the ability of en face slab images of maculae to detect residual nerve fiber bundles in eyes with advanced glaucoma. Methods: This study included 36 eyes with diffuse thinning of the ganglion cell and inner plexiform layers (GCL+IPL). Inclusion criterion was GCL+IPL thickness of <1% of the normative database level as detected using optical coherence tomography (OCT). En face slab images (50-μm thickness) were reconstructed from the macular cube scan data using advanced visualization settings. Thereafter, we assessed the agreement of the locations between hyperreflective nerve fiber bundles and normal points in the Humphrey visual field test 10-2 pattern deviation (PD) plots. Additionally, total deviation (TD) corresponding to hyperreflective and hyporeflective areas was compared. Results: Hyperreflective areas were detected in 31 out of 36 eyes; all 31 eyes exhibited at least one normal PD point despite the substantial GCL+IPL thinning in the macular region. Two eyes with abnormalities in all PD points showed no hyperreflective area. The remaining three eyes had normal PD points despite the lack of high reflectivity areas in the slab images. Therefore, 91.7% of eyes showed agreement between en face slab images and PD plots. Moreover, hyperreflective areas demonstrated significantly better TD than hyporeflective areas. Conclusions: En face slab images of maculae were able to reveal the residual nerve fiber bundles in the eyes with advanced glaucoma despite the GCL+IPL thickness in the maculae being diffusely and substantially reduced.

    01 Jul. 2019, Investigative ophthalmology & visual science, 60 (8), 2811 - 2821, English, International magazine

    [Refereed]

    Scientific journal

  • 緑内障セミナー 小児緑内障の分類

    中西 裕子

    Jun. 2019, あたらしい眼科, 36 (6), 779 - 780, Japanese

    [Refereed]

    Scientific journal

  • 前眼部OCTにより鑑別を行った結膜粘液腫の1例

    山田 裕子, 長井 隆行, 中井 駿一朗, 坂本 麻里, 中村 誠

    (公財)日本眼科学会, Mar. 2019, 日本眼科学会雑誌, 123 (臨増), 311 - 311, Japanese

    [Refereed]

  • Akiko Miki, Yuko Yamada, Makoto Nakamura

    Purpose: To investigate the foveal avascular zone (FAZ) in the eyes of patients with a history of retinopathy of prematurity (ROP) using optical coherence tomography angiography (OCTA) and to identify associated clinical factors. Patients and methods: Overall, 14 children with a history of laser treatment for ROP, 17 children born prematurely without a history of ROP, and 41 age-matched children born at full-term (age range 7-14 years) were included. OCTA was conducted on an area measuring 3 × 3 mm in the central macula. The area of FAZ in the superficial layer was measured. Foveal thickness (FT), ganglion cell complex thickness, and the presence of inner retinal layer (IRL) at the fovea were evaluated. Results: There were significant differences in FT and FAZ size among patients (P < 0.001). The eyes of patients that had been treated for ROP showed the smallest FAZ and greatest FT. Univariate analyses demonstrated that the area of FAZ was not correlated with visual acuity (P=0.078) but with gestational age (GA) (P=0.001), birth weight (P=0.013), the presence of IRL (P < 0.001), and FT (P < 0.001). Multivariate regression analyses showed that the area of FAZ was significantly associated with GA, the presence of IRL, and FT (P=0.03, P=0.01, P < 0.001, respectively). Conclusion: The eyes of preterm children had small FAZ, and this reduction in area was associated with greater FT, the presence of IRL, and lower GA.

    2019, Journal of ophthalmology, 2019, 8340729 - 8340729, English, International magazine

    [Refereed]

    Scientific journal

  • Relationship between vision-related quality of life and central 10° of the binocular integrated visual field in advanced glaucoma

    Yamazaki Y, Sugisaki K, Araie M, Kanamori A, Inoue T, Ishikawa S, Yoshikawa K, Maeda H, Yamada Y, Negi A, Inatani M, Tanihara H, Okinami S, Mizuki K, Mishima K, Uchida K, Matsumoto S

    2019, Scientific Reports, 18 (9), 14990, English

    [Refereed]

    Scientific journal

  • Discordance of disc-fovea raphe angles determined by optical coherence tomography and MP-3 microperimetry in eyes with a glaucomatous hemifield defect

    Mori S, Kurimoto T, Kanamori A, Sakamoto M, Ueda K, Yamada-Nakanishi Y, Nakamura M

    2019, Investigative ophthalmology & visual science, 60 (5), 1403 - 1411, English

    [Refereed]

    Scientific journal

  • The difficulty of diagnosing invasive aspergillosis initially manifesting as optic neuropathy

    Mori S, Kurimoto T, Kawara K, Ueda K, Sakamoto M, Keshi Y, Yamada-Nakanishi Y, Tachibana H, Nakamura M

    2019, Case Reports in Ophthalmology, 10 (1), 11 - 18, English

    [Refereed]

    Scientific journal

  • Takuji Kurimoto, Kaori Ueda, Sotaro Mori, Mari Sakamoto, Yuko Yamada-Nakanishi, Wataru Matsumiya, Makoto Nakamura

    Background: Leber hereditary optic neuropathy (LHON) is a maternally inherited disease caused by three missense mutations of mitochondrial (mt) DNA, ie, m 3460 G>A, m 11778 G>A, or m 14484 T>C in the greater portion of LHON. m 11778 G>A mutation is especially observed in >90% of the cases in Japanese families. Although spontaneous remission of visual function infrequently occurs, effective treatment for LHON remains unestablished. Transcorneal electrical stimulation has been shown to be efficacious in individuals with optic neuropathy. However, due to potential risk of corneal damage, repeated treatments are not permissible. In this exploratory study, we will be conducting skin electrical stimulation (SES) as an intervention for patients with LHON having 11778 missense mutation and investigate effectiveness and safety of SES. Methods: This is a single-arm, prospective, open-label exploratory trial focused on patients with LHON having 11778 missense mutation. Eleven patients will be enrolled and receive six consecutive SES once every 2 weeks up to 10 weeks. The safety of the SES will be monitored with specular microscopy, slit-lamp biomicroscopy, fundus examinations, and the observation of facial skin. The primary outcome measure will be the averaged l ogarithm of minimum angle resolution (logMAR) converted visual acuity 1 week after the last SES. Secondary outcome measures include changes, in logMAR at 4 and 8 weeks after the last SES, such as visual field indices measured using Humphrey visual field and microperimetry-3, the thickness of peripapillary retinal fiber and macular ganglion cell complex, multifocal visual evoked potentials, critical flicker frequency, and color vision. Discussion: The results of this proposed proof-of-concept feasibility trial will help plan and execute a larger definitive trial to test SES as an effective strategy for LHON and related optic neuropathies and help establish a beneficial treatment for LHON.

    2019, Clinical ophthalmology (Auckland, N.Z.), 13 (13), 897 - 904, English, International magazine

    [Refereed]

    Scientific journal

  • Hiroko Yamada, Takuji Kurimoto, Sotaro Mori, Mari Sakamoto, Kaori Ueda, Yuko Yamada-Nakanishi, Yoichi Uozumi, Hiroyasu Shose, Masaaki Taniguchi, Masanori Toyoda, Hironobu Minami, Makoto Nakamura

    Langerhans cell histiocytosis (LCH) is characterised by tissue destruction caused by the abnormal proliferation of pathogenic dendritic cells. We report a rare case of multi-system LCH with local invasion of the orbital apex.A 56-year-old woman suffered from a decrease of visual acuity in the left eye caused by central scotoma and the limitation of eye movement in all directions. Magnetic resonance imaging revealed an enhanced lesion in the left orbital apex, suggesting optic nerve compression. She had been diagnosed with eosinophilic granuloma 24 years previously. Two weeks after the current presentation, we admitted the patient for optic canal and orbital apex decompression and subtotal tumour resection. Histopathological analysis confirmed the diagnosis of LCH. Post-surgical treatment with low-dose cytarabine was initiated for the residual tumour. However, it was ceased because of myelosuppression-induced pyelonephritis. After surgery, the central scotoma disappeared on day 5 and eye movement palsy resolved by 6 months. After the cessation of cytarabine, she has received low-dose steroid therapy for 2 years with no recurrence. Early surgical intervention with low-dose steroid therapy can lead to recovery of visual acuity and resolve eye movement palsy in patients with lesions of the orbital apex caused by multi-system LCH.

    KARGER, 2019, CASE REPORTS IN OPHTHALMOLOGY, 10 (3), 319 - 326, English

    [Refereed]

    Scientific journal

  • 髄膜炎を伴う続発性眼窩炎症と強膜炎を呈した汎発性帯状疱疹の1例

    佐々木 信之, 坂本 麻里, 栗本 拓治, 盛 崇太郎, 上田 香織, 中西 裕子, 飯島 健太, 立花 久嗣, 中村 誠

    日本神経眼科学会, Nov. 2018, 神経眼科, 35 (増補1), 87 - 87, Japanese

    [Refereed]

  • Effectiveness and safety of sulcus fixation of Baerveldt glaucoma implants in glaucomatous eyes in patients who underwent multiple intraocular surgeries

    Mori S, Sakamoto M, Kurimoto T, Kanamori A, Ueda K, Inoue Y, Yamada Yuko, Nakamura Makoto

    Oct. 2018, Graefes Arch Clin Exp Ophthalmol, 256 (10), 1953 - 1960, English

    [Refereed]

    Scientific journal

  • レーベル遺伝性視神経症における視標サイズに基づく中心暗点の評価

    Ueda Kaori, 盛崇太朗, 坂本麻里, 芥子結香子, 栗本拓治, Yamada Yuko, Nakamura Makoto

    Sep. 2018, 神経眼科, 35 (3号), 303 - 308, Japanese

    [Refereed]

    Scientific journal

  • 【続発緑内障】 続発小児緑内障

    Yamada Yuko

    Aug. 2018, あたらしい眼科, 35 (8号), 1057 - 1065, Japanese

    [Refereed][Invited]

    Scientific journal

  • Vasculitis with superior ophthalmic vein thrombosis compatible with neuro-neutrophilic disease

    Sakamoto M, Kurimoto T, Mori S, Ueda Kaori, Keshi Y, Yamada Yuko, Azumi A, Shimono T, Nakamura Makoto

    Aug. 2018, Am J Ophthalmol Case Rep, 12, 39 - 44, English

    [Refereed]

    Scientific journal

  • 緑内障眼における他覚的・自覚的機能検査結果とEn Face slab画像を用いた構造評価結果の相関性の検討

    井上結香子, 鎌田誠子, 盛崇太朗, 上田香織, 坂本麻里, 栗本拓治, Yamada Yuko, 中村誠

    Jul. 2018, 眼科臨床紀要, 11 (7号), 555, Japanese

    [Refereed]

    Scientific journal

  • Optic Neuritis Possibly Induced by Anti-PD-L1 Antibody Treatment in a Patient with Non-Small Cell Lung Carcinoma

    Mori S, Kurimoto T, Ueda Kaori, Enomoto H, Sakamoto M, Keshi Y, Yamada Yuko, Nakamura Makoto

    Jul. 2018, Case Rep Ophthalmol, 9 (2), 348 - 356, English

    [Refereed]

    Scientific journal

  • 緑内障眼における他覚的・自覚的機能検査結果とen face slab画像を用いた構造評価結果の相関性の検討

    井上結香子, 鎌田誠子, 盛崇太朗, 上田香織, 坂本麻里, 栗本拓治, Yamada Yuko, 中村誠

    Mar. 2018, 日本眼科学会雑誌, 122 (3号), 252 - 253, Japanese

    [Refereed]

    Scientific journal

  • 未熟児網膜症既往眼における中心窩無血管領域と固視点安定性の関連

    林田真由香, 三木明子, 中西理恵, 島内深希, 和田友紀, 井上結香子, Yamada Yuko, 中村誠

    Mar. 2018, 日本眼科学会雑誌, 122 (臨増), 307, Japanese

    [Refereed]

    Scientific journal

  • Akiko Miki, Shigeru Honda, Yukako Inoue, Yuko Yamada, Makoto Nakamura

    PURPOSE: This study evaluates optical coherence tomography (OCT) findings of the macula in patients with a history of retinopathy of prematurity (ROP). METHODS: We enrolled 112 patients (age: 6-15 years) and categorized them into 3 groups: gestational age (GA) < 36 weeks with or without a history of ROP (ROP group, preterm group) and GA ≥37 weeks. We included 1 eye of each patient and measured the retinal thickness of the macula by OCT. RESULTS: The ROP group demonstrated the worst VA and the shallowest foveal depression. Furthermore, foveal depression significantly correlated with birth weight, GA, ganglion cell layer/inner plexiform layer (GCL-IPL) thickness, and a history of ROP. CONCLUSIONS: This study established a correlation of fovea formation with premature birth, damage of GCL-IPL, and a history of ROP. The retention of the inner retina possibly contributes to abnormal foveal morphology in patients with a history of ROP.

    2018, Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde, 240 (2), 106 - 110, English, International magazine

    [Refereed]

    Scientific journal

  • Mari Sakamoto, Yoshiko Matsumoto, Sotaro Mori, Kaori Ueda, Yukako Inoue, Takuji Kurimoto, Akiyasu Kanamori, Yuko Yamada, Makoto Nakamura

    Purpose: We previously reported that eyes with hypotony maculopathy (HM) after trabeculectomy (TLE) exhibited more reduction of axial length (AL) than those without HM, suggesting that inward collapse of the scleral wall may contribute to the development of HM after TLE. However, we did not evaluate change in choroidal thickness (CT), which could influence AL measures. We compared the magnitude and rate of AL and CT changes in eyes with and without HM by simultaneously measuring these parameters before and after TLE. Methods We enrolled 77 eyes of 77consecutive patients with glaucoma, who underwent TLE between March 2014 and March 2016. Intraocular pressure (IOP), central corneal thickness, keratometry, AL, and CT were measured pre- and postoperatively, up to 6 months. These biometrics were compared in eyes with and without HM. Results The 14 patients who developed HM were significantly younger than those who did not. The eyes with HM exhibited significantly reduced AL (2.8%) compared to those without HM (0.7%). There was no significant difference in CT change between the two groups. The rate of AL reduction was significantly correlated with age, postoperative IOP, and preoperative AL. Post-adjustment logistic regression analysis revealed that eyes with AL reduction rate 2% had 11.67 higher risk for developing HM (95% confidence interval, 1.28–106.6 P = 0.03). Conclusions AL reduction rates 2% were significantly associated with HM. Excessive reduction in AL, which was seen in eyes with HM, was not an artificial measure resulting from choroidal thickening but rather reflected reductions in the anterior-posterior diameter of the eyeball. Inward collapse of the scleral wall leads to redundancy of the chorioretinal tissue, contributing to the development of HM after TLE.

    Public Library of Science, 01 Jan. 2018, PLoS ONE, 13 (1), e0191862, English

    [Refereed]

    Scientific journal

  • Mari Sakamoto, Sotaro Mori, Kaori Ueda, Azusa Akashi, Yukako Inoue, Takuji Kurimoto, Akiyasu Kanamori, Yuko Yamada, Makoto Nakamura

    Purpose: To assess the combined estimate of retinal ganglion cell (RGC) count developed by Medeiros et al. as a tool for diagnosis of glaucoma in Japanese patients. Study design: Cross-sectional study. Methods: Thirty-one eyes of 19 healthy controls and 106 eyes of 70 glaucoma patients underwent standard automated perimetry (SAP) and three types of spectral domain optical coherence tomography (SD-OCT) imaging using the Cirrus, RTVue, and 3D-OCT instruments. RGC counts derived from SAP and SD-OCT data were estimated using the Harwerth model (SAPrgc and OCTrgc, respectively), from which the combined RGC count estimates (CRGC) were calculated using the formula developed by Medeiros et al. Receiver operating characteristic curve (ROC) analyses were conducted for mean deviation (MD), retinal nerve fiber layer thickness (RNFLT), and CRGC. Results: The mean OCTrgc derived from the Cirrus, RTVue, and 3D-OCT instruments were 1150, 1245, and 1316 (× 1000 cells), respectively, for the control group and 463, 519, and 516 (× 1000 cells), respectively, for the patient group. SAPrgc of the controls’ group was 1526 and the patients’ group, 731 (× 1000 cells), and were consistently greater than OCTrgc in both groups (a generalized estimating equation model, p <  0.001). Partial area under the curve (pAUC) of MD was 0.178, and that of RNFLT and CRGC for the three OCT instruments were 0.185, 0.18, 0.189 and 0.196, 0.196, 0.197, respectively. CRGC had larger pAUC than MD, whereas there was no or marginal difference in pAUC between CRGC and cpRNFLT, irrespective of OCT device used or glaucoma severity. Conclusion: CRGC proved well suited to discriminate glaucoma patients from controls. However, its clinical utility did not seem to overwhelm isolated structural measures in the tested Japanese patients.

    Springer Tokyo, 01 Jan. 2018, Japanese Journal of Ophthalmology, 62 (1), 31 - 40, English

    [Refereed]

    Scientific journal

  • 視神経鞘髄膜腫に対し強度変調放射線治療を施行した神経線維腫症2型の一例

    松野裕樹, Yamada Yuko, 井上結香子, 金森章泰, Nakamura Makoto

    Dec. 2017, 神経眼科, 34 (4号), 449 - 454, Japanese

    [Refereed]

    Scientific journal

  • 未熟児網膜症既往眼における中心窩無血管体についての検討

    三木明子, 中西理恵, 上田香織, 井上結香子, Yamada Yuko, Honda Shigeru, 中村誠

    Nov. 2017, 眼科臨床紀要, 10 (11号), 949, Japanese

    [Refereed]

    Research society

  • 両視神経症の診断に苦慮し剖検にて侵襲性アスペルギルス症と診断された一例

    盛崇太朗, 栗本拓治, 坂本麻里, 上田香織, 井上結香子, Yamada Yuko, 中村誠

    Oct. 2017, 神経眼科, 34 (増補1), 66, Japanese

    [Refereed]

    Symposium

  • 上眼静脈血栓性静脈炎により視力低下・視野障害を生じた一例

    坂本麻里, 盛崇太朗, 上田香織, 井上結香子, 栗本拓治, Yamada Yuko, 中村誠

    Oct. 2017, 神経眼科, 34 (増補1), 110, Japanese

    [Refereed]

    Symposium

  • レーベル遺伝性視神経症における視標サイズに基づく中心暗点の評価

    上田香織, 盛崇太朗, 坂本麻里, 井上結香子, 栗本拓治, Yamada Yuko, 中村誠

    Oct. 2017, 神経眼科, 34 (増補1), 75, Japanese

    [Refereed]

    Symposium

  • ぶどう膜炎と視神経症を発症し、生検にて確定診断に至った結核性肥厚性硬膜炎の1例

    崔龍東, 栗本拓治, 盛崇太朗, 坂本麻里, 上田香織, 井上結香子, Yamada Yuko, 中村誠

    Oct. 2017, 神経眼科, 34 (増補1), 106, Japanese

    [Refereed]

    Symposium

  • 下垂体腫瘍患者における光干渉断層計と静的視野検査および多局所視覚誘発電位の異常検出の一致性

    井上結香子, 盛崇太朗, 上田香織, 坂本麻里, 栗本拓治, 金森章泰, Yamada Yuko, 中村誠

    Jul. 2017, 眼科臨床紀要, 10 (7号), 585 - 586, Japanese

    [Refereed]

    Scientific journal

  • Icare HOMEを用いた眼圧のホームモニタリングおよび日内変動の検討

    坂本麻里, 金森章泰, 盛崇太郎, 上田香織, 井上結香子, 栗本拓治, Yamada Yuko, Nakamura Makoto

    Apr. 2017, 日本眼科学会雑誌, 121 (4号), 366 - 372, Japanese

    [Refereed]

    Scientific journal

  • 流出路再建術の術式別術後短期成績の比較検討

    盛崇太朗, 金森章泰, 坂本麻里, 上田香織, 井上結香子, 栗本拓治, Yamada Yuko, 中村誠

    Mar. 2017, 日本眼科学会雑誌, 121 (臨増), 245, Japanese

    [Refereed]

    Symposium

  • 健常眼における視神経乳頭中心窩線と耳側縫線の解剖学的位置関係の検討

    栗本拓治, 盛崇太朗, 金森章泰, 若林星太, 中西理恵, 坂本麻里, 上田香織, 井上結香子, Yamada Yuko, 中村誠

    Mar. 2017, 日本眼科学会雑誌, 121 (臨増), 209, Japanese

    [Refereed]

    Symposium

  • Yoshiko Matsumoto, Sotaro Mori, Kaori Ueda, Takuji Kurimoto, Akiyasu Kanamori, Yuko Yamada, Ichiro Nakashima, Makoto Nakamura

    Purpose An autoantibody against aquaporin-4 (AQP4 Ab) is highly specific for neuromyelitis optica spectrum disorder and plays a pathogenic role in this disease. The purpose of this study was to investigate the impact of AQP4 Ab on inner retinal structure, function, and the structure -function relationships in eyes with optic neuritis. Methods Thirty five eyes from 25 cases who had received visual function tests and RTVue optical coherence tomography (OCT) measurement at least six months after the latest episode of optic neuritis were enrolled. Patients with multiple sclerosis were excluded. AQP4 Ab was measured using a cell -based assay. Visual acuity, mean deviation (MD) of the Humphrey visual field SITA standard 30-2 tests, retinal nerve fiber layer (RNFL), ganglion cell complex (GCC) thicknesses, and other clinical variables were compared between the AQP4 Ab-positive and-negative groups. Parameters associated with visual functions were evaluated by generalized estimating equation (GEE) models. Results The AQP4 Ab-positive group (20 eyes from 12 cases) had a higher proportion of bilateral involvement and longer duration of follow-up than the AQP4 Ab-negative group (15 eyes from 13 cases). Linear mixed effect models revealed worse MD and visual acuity in AQP4 Ab-positive eyes than those in AQP4 Ab-negative eyes after adjusting for within -patient inter-eye dependence, whereas there were no differences in RNFL and GCC thickness between the two groups. In seropositive eyes, GEE regression analyses revealed that depending on age and the number of recurrences of ON episodes, OCT parameters correlated strongly with MD and more weakly with visual acuity. Conclusions Reductions in RNFL and GCC thickness were proportional to the visual field defect in eyes with AQP4 Ab but not in eyes without AQP4 Ab. The presence of AQP4 Ab probably plays a critical role in retinal ganglion cell loss in optic neuritis.

    PUBLIC LIBRARY SCIENCE, Feb. 2017, PLOS ONE, 12 (2), e0171880, English

    [Refereed]

    Scientific journal

  • 抗AQP4抗体陽性視神経炎に対する血液浄化療法の治療効果

    盛 崇太朗, 栗本 拓治, 坂本 麻里, 上田 香織, 井上 結香子, 千原 典夫, 金森 章泰, 山田 裕子, 中村 誠

    日本神経眼科学会, Oct. 2016, 神経眼科, 33 (増補1), 86 - 86, Japanese

    [Refereed]

  • Schlemm管内皮網除去と深層強膜弁切除を併施した線維柱帯切開術の術後成績

    安田絵里子, 金森章泰, 上田香織, 明石梓, 坂本麻里, 井上結香子, Yamada Yuko, Nakamura Makoto

    Sep. 2016, 日本眼科学会雑誌, 120 (9号), 635 - 639, Japanese

    [Refereed]

    Scientific journal

  • All-trans retinoic acidによる偽脳腫瘍を呈した急性前骨髄性白血病の一例

    広瀬 美樹, 山田 裕子, 明石 梓, 松本 佳子, 三木 明子, 井上 結香子, 金森 章泰, 中村 誠

    眼科臨床紀要会, Apr. 2016, 眼科臨床紀要, 9 (4), 375 - 375, Japanese

    [Refereed]

  • Azusa Akashi, Akiyasu Kanamori, Kaori Ueda, Yukako Inoue, Yuko Yamada, Makoto Nakamura

    PURPOSE. Optical coherence tomography (OCT) instruments do not embed a normative database from highly myopic normal (HMN) eyes. The abilities of three OCT instruments to detect early glaucoma with high myopia were compared using the two controls with or without high myopia. METHODS. A total of 52 early glaucomatous eyes (mean deviation > -6.0 dB) with high myopia (spherical equivalent <= -6.0 diopters [HMG]), 54 HMN eyes, and 90 nonhighly myopic normal (NHMN) eyes were enrolled. Each participant was imaged using Cirrus, RTVue, and Topcon 3D OCT to evaluate the thicknesses of the circumpapillary retinal nerve fiber layer (cpRNFL), the macular retinal nerve fiber layer (mRNFL), ganglion cell layer + inner plexiform layer (GCL/IPL), and mRNFL + GCL/IPL (GCC). The covariate-adjusted areas under the receiver operating characteristic curves (AUCs) for detecting HMG were compared among the instruments and between the two normal groups (HMN or NHMN). RESULTS. Highly myopic normal eyes showed higher AUCs for the temporal quadrant cpRNFL thickness but lower AUCs for the superior and inferior RNFL thicknesses compared with NHMN. We found the AUCs for the GCC thickness showed no significant difference between the two control groups, but the GCL/IPL and mRNFL thicknesses had differences. CONCLUSIONS. The abilities of the three OCT instruments to detect early glaucomatous eyes with high myopia were different if the normal eyes were associated with high myopia or not. A normative database that includes data from patients with high myopia should be established for accurate diagnosis of glaucoma with high myopia. (www.umin.ac.jp/ctr number, UMIN000006900.)

    ASSOC RESEARCH VISION OPHTHALMOLOGY INC, Oct. 2015, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 56 (11), 6573 - 6580, English

    [Refereed]

    Scientific journal

  • Kaori Ueda, Akiyasu Kanamori, Azusa Akashi, Yoshiko Matsumoto, Yuko Yamada, Makoto Nakamura

    Background/aims Chiasmal compression affects the crossed nerve fibres originating from the nasal hemiretina, as opposed to the uncrossed fibres from the temporal hemiretina. The objectives were to evaluate circumpapillary retinal nerve fibre layer (cpRNFL) thickness by spectral-domain optical coherence tomography in eyes with band atrophy (BA) accompanying temporal hemianopia due to chiasmal damage and to estimate the distribution pattern of cpRNFL from the nasal hemiretina. Methods This cross-sectional study included 53 eyes with optic neuropathy due to chiasmal lesions and 72 normal eyes. Visual field sensitivity (VFS) was evaluated by standard automated perimetry. Eyes with abnormalities in the nasal visual hemifield were excluded. The structure-function relationships (cpRNFL thickness and VFS in the temporal hemifield) were evaluated in eyes with BA. The base levels composed of only non-neuronal elements and cpRNFL from the temporal hemiretina were estimated in the average and 12 sector-cpRNFL thicknesses using regression analysis. Results The base level in the average cpRNFL thickness was 71.2 mm in eyes with BA, which corresponded to 70% of average thickness of normal controls. However, the estimated base level of 12 sector-cpRNFL thicknesses represented the unique distribution pattern, in which base level-thickness localised at the 1 o'clock and 5 o'clock sectors was extensively reduced, with an even distribution of base levels at other sectors. Conclusions The RNFL originating from the nasal hemiretina is estimated to enter into the optic disc predominantly at the 1 o'clock and 5 o'clock angles.

    BMJ PUBLISHING GROUP, Oct. 2015, BRITISH JOURNAL OF OPHTHALMOLOGY, 99 (10), 1419 - 1423, English

    [Refereed]

    Scientific journal

  • 未熟児網膜症既往眼の黄斑部における光干渉断層計所見と関連因子の検討

    三木 明子, 本田 茂, 島脇 由香, 松本 佳子, 明石 梓, 山田 裕子, 中村 誠

    (公財)日本眼科学会, Mar. 2015, 日本眼科学会雑誌, 119 (臨増), 290 - 290, Japanese

    [Refereed]

  • Kaori Ueda, Akiyasu Kanamori, Azusa Akashi, Yuki Kawaka, Yuko Yamada, Makoto Nakamura

    To compare the relationship between visual field sensitivity (VFS) and macular parameters measured using three spectral-domain optical coherence tomography (SD-OCT) instruments and to determine a base level (=floor effect) for macular parameters. We imaged 127 glaucomatous eyes (1 eye per subject) using three different OCT instruments, i.e., the Cirrus, RTVue and 3D OCT devices; 76 normal eyes were evaluated as controls using the same instruments. The thicknesses of the macular retinal nerve fiber layer (mRNFL), ganglion cell layer+inner plexiform layer (GCL/IPL), and mRNFL+GCL/IPL (GCC) were analyzed. The VFS of the area analyzed by OCT was expressed in decibels and the 1/Lambert scale. For each parameter, the structure-function relationship and the base level were evaluated by regression analysis. The strength of the correlations between the instruments was compared by the bootstrapping method. All of the macular parameters evaluated exhibited statistically significant correlations with VFS. The average GCC measured by all three SD-OCT instruments and the average mRNFL thickness measured by the Cirrus and 3D OCT instruments had similar correlations with VFS. The average GCL/IPL thickness measured by the Cirrus OCT instrument was better correlated with VFS that was measured by the 3D OCT instrument (p = 0.031). The base level GCC thickness measured by all three instruments was approximately 65 % of that of normal eyes. The base level mRNFL thickness measured with the Cirrus and OCT instruments was 52 and 48 %, respectively, of that of normal eyes. The base level GCL/IPL thickness measured with the Cirrus and 3D instruments was 71 and 75 %, respectively, of that of normal eyes. The three SD-OCT instruments evaluated showed similar structure-function relationships in terms of GCC and mRNFL measurements. The base levels of the macular parameters determined by the three instruments differed, due, at least partly, to the scanning area defined by each instrument.

    SPRINGER JAPAN KK, Jan. 2015, JAPANESE JOURNAL OF OPHTHALMOLOGY, 59 (1), 55 - 64, English

    [Refereed]

    Scientific journal

  • アクアポリン9は乳酸輸送を介して網膜神経節細胞の生存を制御する

    明石 梓, 三木 明子, 井上 結香子, 金森 章泰, 山田 裕子, 中村 誠

    日本緑内障学会, Sep. 2014, 日本緑内障学会抄録集, 25回, 114 - 114, Japanese

    [Refereed]

  • Azusa Akashi, Akiyasu Kanamori, Kaori Ueda, Yoshiko Matsumoto, Yuko Yamada, Makoto Nakamura

    PURPOSE. To assess the diagnostic performance of the macular parameters detected by spectral-domain optical coherence tomography (SD-OCT) in band atrophy (BA) eyes. METHODS. Forty-nine BA eyes with permanent temporal hemianopia and 89 normal eyes were enrolled. Any patients who had nasal visual field loss were excluded. Each participant was imaged by three-dimensional (3D) OCT-2000, and 10 3 10 grids in the macula were automatically allocated. The thickness of the macular retinal nerve fiber layer (mRNFL), ganglion cell layer (GCL) + (GCL+inner plexiform layer [IPL]), and GCL++ (RNFL+GCL+IPL) in both nasal and temporal hemiretina was calculated and compared between the BA and normal eyes. The areas under the receiver operating characteristic curves (AUCs) in these parameters were compared between the nasal hemiretina and the temporal hemiretina. RESULTS. All the parameters in the BA eyes were significantly thinner than those in the normal eyes. The AUCs for the mRNFL, GCL+, and GCL++ thickness in the nasal hemiretina were 0.890, 0.988, and 0.981, respectively. The parameters in the nasal hemiretina showed significantly higher AUCs than those parameters in the temporal hemiretina. In the temporal hemiretina, the damaged grids in the mRNFL were located in the arcuate areas in each hemifield. CONCLUSIONS. The inner macular parameters in the nasal hemiretina exhibited high diagnostic abilities to detect BA. The GCL+ was more affected than mRNFL. The characteristic pattern of mRNFL and GCL+ thinning was implicated in the anatomical architecture regarding the nasotemporal overlap of the crossed and uncrossed fibers around the fovea. (www.umin.ac.jp/ctr number, UMIN000006900.)

    ASSOC RESEARCH VISION OPHTHALMOLOGY INC, Jul. 2014, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 55 (7), 4667 - 4672, English

    [Refereed]

    Scientific journal

  • Mari Sakamoto, Akiyasu Kanamori, Masashi Fujihara, Yuko Yamada, Makoto Nakamura, Akira Negi

    WILEY-BLACKWELL, May 2014, ACTA OPHTHALMOLOGICA, 92 (3), 243 - 248, English

    [Refereed]

    Scientific journal

  • Yoshiko Matsumoto, Masashi Fujihara, Akiyasu Kanamori, Yuko Yamada, Makoto Nakamura

    To measure changes in axial length before and after trabeculectomy with noncontact, partial coherence laser interferometry and identify patient factors that lead to the development of hypotony maculopathy and axial length shortening in 25 eyes with intraocular pressure (IOP) a parts per thousand currency sign6 mmHg at 4 weeks after mitomycin C-augmented trabeculectomy. A retrospective comparative case series. Hypotony maculopathy was identified with both ophthalmoscopy and spectral-domain optical coherence tomography. Axial length and IOP were serially measured pre- and postoperatively. Logistic regression analysis was performed to identify factors associated with the presence of hypotony maculopathy at 4 weeks after trabeculectomy and multiple regression analysis to identify factors associated with axial length changes. Ten eyes exhibited hypotony maculopathy, whereas the remaining 15 did not. Patients with hypotony maculopathy were significantly younger (47.7 +/- A 6.2 years) compared with those without it (63.3 +/- A 9.6 years, P = 0.0002, unpaired t test). The percent reduction of axial length after trabeculectomy was significantly larger in the former group (5.91 +/- A 2.76 %) compared with the latter group (1.51 +/- A 0.91 %) (P = 0.0001, Mann-Whitney U test). Multivariate analyses showed that only age was associated with the presence of hypotony maculopathy, with an odds ratio of 0.82 (P = 0.0075), when age, sex, type of glaucoma, lens status, percent changes in axial length and IOP before and after trabeculectomy, and central corneal thickness were included as independent variables (R (2) = 0.543, P = 0.003). Age-dependent axial length reduction is a risk factor for the development of hypotony maculopathy after trabeculectomy.

    SPRINGER JAPAN KK, May 2014, JAPANESE JOURNAL OF OPHTHALMOLOGY, 58 (3), 267 - 275, English

    [Refereed]

    Scientific journal

  • Mari Sakamoto, Akiyasu Kanamori, Masashi Fujihara, Yuko Yamada, Makoto Nakamura, Akira Negi

    Purpose: To evaluate the precision of the IcareONE rebound tonometer, which was developed for self-measuring intraocular pressure (IOP) and to compare IcareONE measurement with Goldmann applanation tonometry (GAT). Methods: Twenty-four healthy eyes and 81 glaucomatous eyes were enrolled. IOP measurements (three times per session) with IcareONE were made in a random order by an ophthalmologist (Icare(O)) and by the subject (Icare(S)). Intraclass correlation coefficients (CCs), kappa values and mean values of IOP were compared among the two types of Icare recordings and GAT. Bland-Altman analysis was used to assess agreement between methods. Multiple regression analysis was performed to identify the subject factors that influenced the discordant measurements between IcareONE and GAT. Results: The mean value of Icare(O) and Icare(S) measurements was 13.5 ± 5.2 and 13.5 ± 5.4 mmHg, respectively, neither of which was significantly different from GAT (13.8 ± 4.4). The intrarater CC of Icare(O) and Icare(S) was 0.968 and 0.885, respectively. The intermethod CC and weighted kappa between Icare(O) and Icare(S) were 0.907 and 0.684, respectively. All pairwise correlations between the two types of IOP measurement showed coefficients of determination > 0.8. Bland-Altman analysis did not show any proportional biases. Multiple regression analysis revealed that the differences between GAT and Icare(O) or Icare(S) were positively correlated with central corneal thickness (CCT) and negatively correlated with age. Conclusions: Intraocular pressure measurements with IcareONE by a physician and by the subject showed excellent agreement with GAT measurements IcareONE measurements between a physician and the subject had high intrarater reliability, and good agreement thicker CCT led IcareONE measurement to overestimate IOP, while higher age caused it to underestimate IOP compared with GAT. © 2013 Acta Ophthalmologica Scandinavica Foundation. Published by Blackwell Publishing Ltd.

    Blackwell Publishing Ltd, 2014, Acta Ophthalmologica, 92 (3), 243 - 248, English

    [Refereed]

    Scientific journal

  • Azusa Akashi, Akiyasu Kanamori, Makoto Nakamura, Masashi Fujihara, Yuko Yamada, Akira Negi

    PURPOSE. We compared the ability of circumpapillary retinal nerve fiber layer (cpRNFL) thickness and macular parameters obtained by three spectral-domain optical coherence tomography (SD-OCT) instruments to detect glaucoma. METHODS. We enrolled 87 normal eyes and 145 glaucomatous eyes (75 early glaucomatous eyes (EGs), mean deviation > -6 dB). Each participant was imaged using Cirrus, RTVue, and 3D-OCT to evaluate the average and quadrant cpRNFL thicknesses. The macular retinal nerve fiber layer (mRNFL), ganglion cell layer plus inner plexiform layer (GCL/IPL), and mRNFL + GCL/IPL (ganglion cell complex [GCC]) thicknesses were analyzed. The areas under the receiver operating characteristic curves (AUCs) were compared among the instruments. RESULTS. These instruments revealed similar AUCs for the average cpRNFL and GCC thicknesses in EGs, and total all-stage glaucomatous eyes (TGs). RTVue showed better performance in the nasal cpRNFL thickness than Cirrus and 3D-OCT, and better performance in the temporal cpRNFL thickness than 3D-OCT in TGs. RTVue had a higher AUC for the superior GCC thickness compared to Cirrus and 3D-OCT in EGs, and TGs. Cirrus had higher AUCs for GCL/IPL parameters in TGs, and lower AUCs for the mRNFL parameters in EGs and TGs compared to 3D-OCT. CONCLUSIONS. The average cpRNFL and GCC thicknesses measured using these OCT instruments exhibited similar abilities in the diagnosis of glaucoma, and RTVue exhibited better diagnostic abilities than Cirrus and 3D-OCT for nasal cpRNFL, and superior GCC thicknesses. The diagnostic performance of Cirrus and 3D-OCT was different for GCL/IPL and mRNFL parameters. (http://www.umin.ac.jp/ctr number, UMIN000006900.)

    ASSOC RESEARCH VISION OPHTHALMOLOGY INC, Jul. 2013, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 54 (7), 4478 - 4484, English

    [Refereed]

    Scientific journal

  • 長期経過において形態変化を認めた網膜つた状血管腫の1例

    三木 明子, Yamada Yuko, 金森 章泰, 中村 誠, 根木 昭

    May 2013, 眼科臨床紀要, 6 (5号), 408, Japanese

    Research society

  • Akiyasu Kanamori, Makoto Nakamura, Mari Tomioka, Yuki Kawaka, Yuko Yamada, Akira Negi

    Purpose: To compare the relationships of parapapillary retinal nerve fibre layer (RNFL) thickness among three spectral-domain optical coherence tomography (SD-OCT) instruments with visual field sensitivity (VFS). Methods: One hundred and thirteen eyes of 113 Japanese subjects with glaucoma (mean deviation in standard automated perimetry = -8.9 +/- 6.7 dB) were imaged by Cirrus, RTVue and 3D OCT. The average hemi-superior and hemi-inferior RNFL thicknesses were obtained. In addition, the structure-function relationship using two retinotopic maps that consisted of six or nine sectors was also evaluated. Decibel (dB) scale and 1/Lamert (1/L) were used to express VFS. RNFL thickness correlation with corresponding VFS in visual field sectors was compared among the three instruments. Background RNFL thickness (non-neuronal tissue) for each instrument was estimated using a linear regression model at 1/L = 0. Results: The correlation between the average hemi-superior and hemi-inferior RNFL thickness in the three SD-OCT instruments with corresponding VFS was similar. In the analysis of retinotopic maps, 3D OCT showed a higher correlation in superotemporal sectors than RTVue, whereas RTVue had a stronger relationship in the nasal sector than Cirrus. The background RNFL thickness extrapolated was approximately 60% that of normal eyes in all the instruments. Conclusions: The three SD-OCT showed similar overall correspondence with VFS with a partially discordant retinotopic relationship. RNFL measured with any SD-OCT devices likely contains non-neuronal tissue, comprising 60% of its thickness.

    WILEY-BLACKWELL, May 2013, ACTA OPHTHALMOLOGICA, 91 (3), E196 - E202, English

    [Refereed]

    Scientific journal

  • 小児緑内障 小児緑内障における治療とその選択

    Yamada Yuko

    Mar. 2013, Frontiers in Glaucoma, (45号), 33 - 35, Japanese

    Symposium

  • 3種のSD-OCTの乳頭周囲網膜神経線維層厚と視野の相関

    明石 梓, 金森 章泰, 坂本 麻里, 藤原 雅史, Yamada Yuko, 中村 誠, 根木 昭

    Mar. 2013, 日本眼科学会雑誌, 117 (臨増), 334, Japanese

    Research society

  • Akiyasu Kanamori, Makoto Nakamura, Yuko Yamada, Akira Negi

    Unilateral injury of the optic tract leads to asymmetrical optic atrophy in both eyes derived from the crossing of the nerve fibers at the chiasm. This report demonstrates unique imaging appearances of optic atrophy due to this uncommon condition detected by spectral-domain optical coherence tomography (SD-OCT). Cirrus and RTVue measurements were performed in four cases of optic tract syndrome. Circumpapillary retinal nerve fiber layer (cpRNFL) thickness was obtained from both instruments and ganglion cell complex (GCC) integrity was obtained from RTVue. The presumable reduction rates of quadrant cpRNFL thickness were calculated from the published normative database and compared between eyes with temporal hemianopia and those with nasal hemianopia. Both devices showed significant reduction of cpRNFL thickness, but did not have statistical difference in the reduction rates at temporal or nasal quadrant cpRNFL between contralateral and ipsilateral eyes to the lesion. Color-coded maps helped to visualize the unique pattern of cpRNFL and GCC thinning. SD-OCT can be used as a diagnostic tool for the optic tract syndrome.

    SPRINGER, Feb. 2013, GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 251 (2), 591 - 595, English

    [Refereed]

    Scientific journal

  • 3種のSD-OCTによる視神経乳頭周囲網膜神経層厚における各象限の比較

    Kanamori Akiyasu, Yamada Yuko, Nakamura Makoto, Negi Akira

    Jan. 2013, 日本視能訓練士協会誌, 41, 286, Japanese

    Research society

  • Azusa Akashi, Akiyasu Kanamori, Makoto Nakamura, Masashi Fujihara, Yuko Yamada, Akira Negi

    PURPOSE. To compare the ability of circumpapillary retinal nerve fiber layer (cpRNFL) thickness and macular parameters obtained by three spectral-domain optical coherence tomography (SD-OCT) instruments to detect highly myopic glaucoma. METHODS. In this study, 84 glaucomatous eyes, 53 normal eyes with high myopia, and 86 normal eyes (not highly myopic) were enrolled. Each participant was imaged using Cirrus, RTVue, and 3D OCT to evaluate the average and quadrant cpRNFL thicknesses. The macular retinal nerve fiber layer (mRNFL), ganglion cell layer {thorn} inner plexiform layer (GCL/IPL), and mRNFL {thorn} GCL/IPL (GCC) thicknesses were analyzed. The areas under the receiver operating characteristic curves (AUCs) were compared between the instruments. In addition, the best parameters for the AUC were compared between the cpRNFL parameters and macular parameters in each instrument. RESULTS. These analyses revealed similar AUCs for the average cpRNFL and GCC thicknesses between the instruments. RTVue displayed a significantly higher AUC in the nasal cpRNFL thickness than both Cirrus (P = 0.0004) and 3D OCT (P = 0.0006). 3D OCT showed higher AUCs than Cirrus in the mRNFL parameters. There were no significant differences between the best cpRNFL parameters and macular parameters in each instrument. CONCLUSIONS. The average cpRNFL and GCC thicknesses that were measured using these OCT instruments exhibited similar abilities for diagnosing highly myopic glaucoma, and RTVue exhibited better diagnostic abilities than Cirrus and 3D OCT for nasal cpRNFL. 3D OCT had better ability than Cirrus in the mRNFL. Both cpRNFL and GCC in each instrument were comparable, and their measurements offered good ability for diagnosing glaucoma with high myopia. © 2013 The Association for Research in Vision and Ophthalmology, Inc.

    2013, Investigative Ophthalmology and Visual Science, 54 (9), 6025 - 6032, English

    [Refereed]

    Scientific journal

  • Akiyasu Kanamori, Maiko Naka, Azusa Akashi, Masashi Fujihara, Yuko Yamada, Makoto Nakamura

    Purpose. Using spectral-domain optical coherence tomography (SD-OCT), we assessed the ability of cluster analyses, based on the grid-pattern of macular parameters, to detect glaucoma. Methods. We enrolled 75 normal eyes, 64 early glaucomatous eyes (EG), and 40 preperimetric glaucomatous eyes (PPG). Each participant was imaged using 3-dimensional optical coherence tomography (3D-OCT) to examine the macular retinal nerve fiber layer (mRNFL) and the thickness of the ganglion cell layer, together with the inner plexiform layer (GCL/IPL). Diagnostic criteria based on the clustering of abnormal grids from the mRNFL and GCL/IPL measurements were applied. The sensitivity and specificity of glaucoma detection were compared between the cluster criteria (CC) and the average thickness criteria (ATC) of total and hemiretinal sectors, and the cut-off criteria were determined using receiver operating characteristic (ROC) curve analyses from our normal controls. Results. The specificity values of CC and ATC from mRNFL measurements were 97% and 100%, respectively. The sensitivity of CC was 94% for EG and 68% for PPG. The sensitivity of ATC was 81% for EG and 38% for PPG. The specificity values of CC and ATC from GCL/IPL measurements were 96% and 100%, respectively. The sensitivity values of CC and ATC were 92% for EG and 63% for PPG. The sensitivity of ATC was 84% for EG and 25% for PPG. When compared to ATC and ROC-based cut-off criteria, CC showed a higher diagnostic capability. Conclusions. Judging abnormality based on a clustering of abnormal grids from macular OCT parameters may be a reliable approach for diagnosing early glaucoma. © 2013 The Association for Research in Vision and Ophthalmology, Inc.

    2013, Investigative Ophthalmology and Visual Science, 54 (9), 6401 - 6408, English

    [Refereed]

    Scientific journal

  • 小脳髄膜腫により腫瘍随伴性視神経症を発症した一例

    Kanamori Akiyasu, Yamada Yuko, Nakamura Makoto, Mizukawa Katsu, Negi Akira

    Oct. 2012, 神経眼科, 29 (増補1), 59, Japanese

    Research society

  • Makoto Nakamura, Kumiko Ishikawa-Tabuchi, Akiyasu Kanamori, Yuko Yamada, Akira Negi

    To assess the agreement and diagnostic performance between retinal nerve fiber layer (RNFL) thickness measurements obtained using the Cirrus (Carl Zeiss Meditec) and RTVue (Optovue Inc.) devices for detection of band atrophy (BA) in patients with permanent temporal hemianopia. In this retrospective study, 26 eyes with BA and 64 control eyes were enrolled. The Cirrus optic disc cube protocol and the RTVue optic nerve head map protocol were used. The Cirrus measurements were extracted and regrouped to be topographically matched with the RTVue measurements. Concordance correlation and 95 % limits of agreement were assessed. Areas under the receiver operating characteristic curves (AUC) and the Spearman's correlation coefficient between average Humphrey total deviation in the temporal hemifield and average RNFL thickness were calculated. RTVue measured consistently thicker values than Cirrus in controls, whereas in eyes with BA, nasal segment measurements from the RTVue were thinner than those obtained using the Cirrus. Each quadrant showed moderate to close agreement in controls, whereas in eyes with BA, the nasal and temporal quadrants exhibited poor agreement. The RTVue measurements demonstrated significantly higher AUCs for nasal segments just above (0.95) and below (0.96) the horizontal meridian than Cirrus measurements (0.80 and 0.66, respectively) and a significant correlation with visual field loss (r(s) = 0.46, P = 0.02 for RTVue vs. r(s) = 0.26, P = 0.22 for Cirrus). The RTVue RNFL thickness measurements in nasal sectors showed better diagnostic performance in detecting BA and higher correlations with temporal hemianopia than the Cirrus measurements.

    SPRINGER, Oct. 2012, GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 250 (10), 1499 - 1507, English

    [Refereed]

    Scientific journal

  • 小児緑内障 小児緑内障における治療とその選択

    Yamada Yuko

    Sep. 2012, 日本緑内障学会抄録集23回, 53, Japanese

    Research society

  • 自己眼圧測定器icareONEの精度および安全性の検討

    Kanamori Akiyasu, Fujihara Masashi, Yamada Yuko, Nakamura Makoto, Negi Akira

    Sep. 2012, 日本緑内障学会抄録集23回, 153, Japanese

    Research society

  • ロジスティック回帰分析による線維柱帯切除術後の低眼圧黄斑症寄与因子の検討

    Fujihara Masashi, Kanamori Akiyasu, Yamada Yuko, Nakamura Makoto, Negi Akira

    Sep. 2012, 日本緑内障学会抄録集23回, 116, Japanese

    Research society

  • 3種のOCTによる高度近視群、非高度近視群における緑内障検出力の比較

    Kanamori Akiyasu, Fujihara Masashi, Yamada Yuko, Nakamura Makoto, Negi Akira

    Sep. 2012, 日本緑内障学会抄録集23回, 155, Japanese

    Research society

  • Longitudinal Study of Retinal Nerve Fiber Layer Thickness and Ganglion Cell Complex in Traumatic Optic Neuropathy

    Akiyasu Kanamori, Makoto Nakamura, Yuko Yamada, Akira Negi

    AMER MEDICAL ASSOC, Aug. 2012, ARCHIVES OF OPHTHALMOLOGY, 130 (8), 1067 - 1069, English

    [Refereed]

    Scientific journal

  • Akiyasu Kanamori, Makoto Nakamura, Kumiko Tabuchi, Yuko Yamada, Akira Negi

    To evaluate the effects of ocular rotation on parapapillary retinal nerve fiber layer (RNFL) thickness measured by spectral-domain optical coherence tomography (SD-OCT). Eighty-eight normal and 205 glaucomatous eyes were studied. RNFL thickness was measured by 3D OCT. Ocular rotation angle was measured from a fundus image obtained by a non-mydriatic fundus camera equipped with 3D OCT. The average, hemi-superior, and hemi-inferior RNFL thicknesses as well as those in the 4 quadrants and the 16-segmented superotemporal (ST-1) and inferotemporal (IT-4) sectors were compared both before and after correcting for ocular rotation. Receiver operating characteristic curves and the areas under the curve (AUC) for the RNFL thicknesses were calculated on the basis of the data from glaucomatous and control eyes. The relationships between RNFL thickness and retinal sensitivity in the corresponding visual field were analyzed using a Humphrey field analyzer. Correction for ocular rotation did not affect the AUCs of the hemi-superior and hemi-inferior RNFL thicknesses. RNFL thicknesses in all of the quadrants and in ST-1 and IT-4 were significantly changed by correcting for ocular rotation. The correlations between all RNFL sectors and retinal sensitivity were not changed by correcting for the ocular rotation angle. Ocular rotation compensation affected RNFL thickness measurement with 3D OCT. However, the effect was clinically negligible in the diagnosis of glaucoma.

    SPRINGER TOKYO, Jul. 2012, JAPANESE JOURNAL OF OPHTHALMOLOGY, 56 (4), 354 - 361, English

    [Refereed]

    Scientific journal

  • Akiyasu Kanamori, Makoto Nakamura, Mari Tomioka, Yuki Kawaka, Yuko Yamada, Akira Negi

    Backgrounds/aims To evaluate the agreement of parapapillary retinal nerve fibre layer (RNFL) thickness among three spectral-domain optical coherence tomography (OCT) instruments. Methods Two hundred and three glaucomatous eyes and 88 normal eyes were imaged by Cirrus, RTVue and 3D OCT. The average and the four quadrant RNFL thicknesses were evaluated. Agreement among RNFL measurements was evaluated using Bland-Altman analysis and linear regression analysis. The percentage of each quadrant in the average RNFL thickness value was compared among the three instruments. Results Cirrus showed significantly smaller thickness values than RTVue (difference=8.8 mu m, p<0.0001) and 3D OCT (difference=8.1 mu m, p<0.0001). Although RNFL measurements among the instruments were highly correlated, the Bland-Altman analysis revealed proportional biases for most of the pair-wise agreements. Additionally, 3D OCT showed strong proportional biases with RTVue and 3D OCT. RTVue had a smaller occupied proportion of nasal quadrants (30.2%) and a larger proportion of inferior quadrants (32.4%) compared with Cirrus and 3D OCT. Conclusions RNFL measurements among the instruments were well correlated but had different values for thickness. The measurement circle of RTVue might be more superior-temporally located compared with the other instruments. Differences in the measurement protocols might be affected by the disagreements. These instruments should not be used interchangeably.

    BMJ PUBLISHING GROUP, Jun. 2012, BRITISH JOURNAL OF OPHTHALMOLOGY, 96 (6), 832 - 837, English

    [Refereed]

    Scientific journal

  • 外傷性視神経症における網膜神経線維層厚およびGanglion cell complexの経時的変化

    Kanamori Akiyasu, Yamada Yuko, Nakamura Makoto, Negi Akira

    Mar. 2012, 日本眼科学会雑誌, 116 (臨増), 361, Japanese

    Research society

  • Makoto Nakamura, Maiko Naka, Yasuko Tatsumi, Azusa Nagai-Kusuhara, Akiyasu Kanamori, Yuko Yamada, Akira Negi

    Purpose/Aim: To determine whether amniotic membrane transplantation (AMT) at trabeculectomy affects intrableb structures and which intrableb parameters are significantly correlated with the long-term intraocular pressure (IOP) control. Materials and Methods: Enrolled were 64 eyes of 56 glaucoma patients who underwent trabeculectomy without (36 eyes) or with (28 eyes) AMT. Bleb structure was evaluated by ultrasound biomicroscopy (UBM) at least one year after surgery. IOP control was defined as good when the eyes had a more than 30% decrease in the preoperative IOP and an IOP value < 18 mmHg if the preoperative IOP was higher than 21 mmHg. Logistic regression analyses were conducted to identify factors significantly associated with IOP control. Results: Intervals between surgery and the timing of the UBM examinations (median; 2.5 years) and the overall frequency of good IOP control (28/36 in the eyes without AMT and 17/28 in those with AMT; chi-square test, P = 0.2276) were similar in the two groups. The eyes with AMT had a significantly lower number of type H (high reflective) or L (low reflective) blebs and a higher number of type E (encapsulated) blebs compared to those without AMT (P < 0.0001). Among independent variables, which included age, sex, glaucoma type, lens status, the number of ocular hypotensives, and previous intraocular surgeries, only type F (flattened) bleb in eyes without AMT (P = 0.0008, odds ratio [ OR] = 0.0256) and no or limited intrableb fluid-filled space in eyes with AMT were significantly associated with poor IOP control (P = 0.0026, OR = 0.0111, and 0.0071, 0.0167, respectively). Conclusions: Intrableb structures after trabeculectomy alone versus AMT-assisted trabeculectomy were distinct. The bleb wall reflectivity in the former and the extent of the subconjunctival fluid-filled space in the latter were factors associated with long-term IOP control.

    INFORMA HEALTHCARE, Mar. 2012, CURRENT EYE RESEARCH, 37 (3), 239 - 250, English

    [Refereed]

    Scientific journal

  • 二種のスペクトラル・ドメイン光干渉断層計のband atrophy検出能と一致性の検討

    Yamada Yuko

    Oct. 2011, 神経眼科, 28巻, 増補1, pp. 80-80, Japanese

    International conference proceedings

  • 乳頭周囲網膜神経線維層厚における眼球回旋の影響

    Yamada Yuko

    Sep. 2011, 日本緑内障学会抄録集22回, 巻, , pp. 99-99, Japanese

    International conference proceedings

  • 眼内レンズ嚢内固定眼に生じた色素緑内障の一例

    Yamada Yuko

    Sep. 2011, 日本緑内障学会抄録集22回, 巻, , pp. 126-126, Japanese

    International conference proceedings

  • 3種のスペクトラルドメイン光干渉断層計による視神経乳頭周囲網膜神経層厚の相関と一致性

    Yamada Yuko

    Sep. 2011, 日本緑内障学会抄録集22回, 巻, , pp. 95-95, Japanese

    International conference proceedings

  • 当院における視神経鞘髄膜腫の検討

    Yamada Yuko

    Jun. 2011, 眼科, 53巻, 6号, pp. 830-830, Japanese

    International conference proceedings

  • 多チャンネル多局所視覚誘発電位と視野の緑内障眼における構造変化との関連

    Yamada Yuko

    Jun. 2011, 眼科臨床紀要, 4巻, 6号, pp. 583-584, Japanese

    International conference proceedings

  • Junji Mizokami, Yuko Yamada, Akira Negi, Makoto Nakamura

    To determine if asymmetrical postural change-induced elevations in intraocular pressure (IOP) in eyes of patients with primary open-angle glaucoma (POAG) were associated with asymmetries in functional and structural damage. Enrolled were 132 eyes of 66 patients with POAG (male/female = 22/44, age = 55.2 +/- 13.4 years). IOP was first measured in a seated position and then in a supine position at 10-minute intervals over a 60-minute period using a TonoPen XL. The Humphrey visual field 30-2 program and a fast retinal nerve fiber layer (RNFL) thickness acquisition protocol of Stratus optical coherence tomography (OCT) were performed. Mean deviation (MD) and average total RNFL thickness were compared between eyes with the greater magnitude of postural change-induced IOP elevation (Delta IOP) and those with the smaller magnitude of Delta IOP. The MDs of the eyes with larger Delta IOP (6.21 +/- 3.18 mmHg) and smaller Delta IOP (3.02 +/- 0.37 mmHg) were -12.31 +/- 7.63 dB and -9.67 +/- 6.80 dB respectively (p = 0.0176). The average total RNFL thickness was 64.33 +/- 17.83 mu m in the former and 68.56 +/- 15.10 mu m in the latter (p = 0.049). The MDs and RNFL thickness were not significantly different between the eyes that had higher and lower IOP values measured in the seated position. In patients with asymmetrical POAG, the magnitude of IOP elevation induced by postural changes may be related to differences in the severity of both functional and structural damage between the eyes.

    SPRINGER, Jun. 2011, GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 249 (6), 879 - 885, English

    [Refereed]

    Scientific journal

  • 小児緑内障難治例に対する羊膜移植併用線維柱帯切除術の術後経過について

    Yamada Yuko

    May 2011, 眼科臨床紀要, 4巻, 5号, pp. 472-472, Japanese

    International conference proceedings

  • Kumiko Ishikawa, Takayuki Nagai, Yuko Yamada, Akira Negi, Makoto Nakamura

    The purpose of this study was to establish optimal conditions for recording multifocal visual evoked potentials (mVEPs) in Japanese individuals, whose skull frame presumably differs from Caucasians. The scalp point that was extended from the calcarine fissure was identified using magnetic resonance imaging scans of 200 subjects. MVEPs were recorded from 56 individuals using three single channels and combinations of vertical and horizontal channels. Five electrodes were placed at the inion, 4 cm above the inion, 2.5 cm below the inion, 4 cm to the left or 4 cm to the right of the inion. The signal-to-noise ratio (SNR) was obtained by measuring the root-mean-square (RMS) amplitude of a signal window (45-150 ms) from each of 60-local responses that was divided by the average of the 60 RMS amplitudes of the noise window (325-430 ms). Receiver operating characteristic (ROC) analyses were performed based on the proportion of mVEP responses that exceeded a specific SNR criterion, calculated for both the signal window and the noise window. The position of the calcarine fissure relative to the inion was significantly lower than the value reported for Caucasians. The ROC analyses disclosed that bi-channel combinations (one vertical and one horizontal) had significantly better performance to discriminate signal from noise in 60-local mVEP responses compared to any single channel and performed similarly to the tri-channel combination. Two sets of perpendicular channels should be simultaneously used in recording mVEP responses from Japanese people, among whom skull frame characteristics differ from those observed in Caucasians.

    SPRINGER, Feb. 2011, DOCUMENTA OPHTHALMOLOGICA, 122 (1), 29 - 37, English

    [Refereed]

    Scientific journal

  • 性ホルモン薬の長期内服が誘引と思われる脳静脈洞血栓症の1例

    Yamada Yuko

    Nov. 2010, 神経眼科, 27巻, 増補1, pp. 86-86, Japanese

    International conference proceedings

  • 小児緑内障難治例に対する羊膜移植併用線維柱帯切除術の術後経過について

    Yamada Yuko

    Oct. 2010, 日本眼科学会雑誌, 114巻, 10号, pp. 891-891, Japanese

    International conference proceedings

  • Melanoma-Associated Retinopathyの1例

    Yamada Yuko

    Oct. 2010, 眼科臨床紀要, 3巻, 10号, pp. 1021-1021, Japanese

    International conference proceedings

  • 日本人の正常眼における多チャンネル多局所視覚誘発電位の検討

    Yamada Yuko

    Jul. 2010, 眼科臨床紀要, 3巻, 7号, pp. 701-702, Japanese

    International conference proceedings

  • 多チャンネル多局所視覚誘発電位による緑内障検出能の検討

    Yamada Yuko

    Mar. 2010, 日本眼科学会雑誌, 114巻, 臨増, pp. 335-335, Japanese

    International conference proceedings

  • 内境界膜剥離併用硝子体手術がラタノプロストによる黄斑浮腫のトリガーとなった正常眼圧緑内障の一例

    Yamada Yuko

    Nov. 2009, 日本緑内障学会抄録集20回, 巻, , pp. 142-142, Japanese

    International conference proceedings

  • 小児白内障術後無水晶体眼における中心角膜厚の検討

    Yamada Yuko

    Jun. 2009, 眼科臨床紀要, 2巻, 6号, pp. 564-564, Japanese

    International conference proceedings

  • ディスポーザブルプリズムによるゴールドマン圧平眼圧計の測定値評価

    Yamada Yuko

    Mar. 2009, 日本眼科学会雑誌, 113巻, 臨増, pp. 276-276, Japanese

    International conference proceedings

  • Serous Macular Detachment Due to Diabetic Papillopathy Detected Using Optical Coherence Tomography

    Makoto Nakamura, Akiyasu Kanamori, Azusa Nagai-Kusuhara, Sentrao Kusuhara, Yuko Yamada, Akira Negi

    AMER MEDICAL ASSOC, Jan. 2009, ARCHIVES OF OPHTHALMOLOGY, 127 (1), 105 - 107, English

    [Refereed]

    Scientific journal

  • Regional Relationship Between Retinal Nerve Fiber Layer Thickness and Corresponding Visual Field Sensitivity in Glaucomatous Eyes

    Akiyasu Kanamori, Maiko Naka, Azusa Nagai-Kusuhara, Yuko Yamada, Makoto Nakamura, Akira Negi

    Objective: To establish the structure-function relationship between peripapillary retinal nerve fiber layer (RNFL) thickness and visual field (VF) test points in standard automated perimetry. Methods: We included 213 eyes with open-angle glaucoma and VF loss in this cross-sectional study. Correlations between individual VF sensitivity at 52 test points and peripapillary RNFL thickness divided into 16 sectors were calculated. The RNFL thickness was measured by Stratus optical coherence tomography. A new VF cluster map corresponding to RNFL sectors was generated by grouping the VF test points with the highest relation to each RNFL sector. Results: The VF sensitivity at each test point was significantly correlated with the sectoral RNFL thickness. The highest coefficient of determination (R-2) for a superotemporal RNFL sector and VF sensitivity at an inferotemporal test point (9 degrees temporal and 15 degrees inferior from the center) in standard automated perimetry was 0.500 (P <.001). Clustered VF test points most highly related to the RNFL sectors were asymmetrically located between the upper and lower hemifields. A newly developed map revealed significant structure-function relationships. Conclusions: We describe an association between VF sensitivity at test points and sectoral RNFL thickness. Nine clustered VF test points corresponding to 9 RNFL regions were demonstrated from the structure-function relationships.

    AMER MEDICAL ASSOC, Nov. 2008, ARCHIVES OF OPHTHALMOLOGY, 126 (11), 1500 - 1506, English

    [Refereed]

    Scientific journal

  • A. Nagai-Kusuhara, M. Nakamura, Y. Tatsumi, Y. Nakanishi, A. Negi

    Background/aims: To evaluate to what extent the optic nerve head (ONH) parameters as measured with Heidelberg Retina Tomograph (HRT) differed from those measured with optical coherence tomography (OCT) in eyes with compressive optic neuropathy (CON) that had band atrophy (BA) of the optic disc. Methods: A total of 30 eyes from 19 patients with BA due to chiasmal tumour and 162 eyes from 162 normal subjects were examined with HRT and Stratus OCT using the fast optic nerve scan protocol. Parameters measured by the two devices, including the disc area, cup/disc (C/D) area ratio, cup area, cup volume, rim area and rim volume, were compared between the eyes of BA patients and controls. Bland-Altman plots were used to evaluate agreement for each parameter between OCT and HRT in both groups of eyes. Intermethod discrepancy of the measurements for each parameter was compared between the two groups of eyes. Results: Eyes with BA had smaller cup and larger rim parameters than control eyes when measured with HRT, whereas they had significantly larger cup and significantly smaller rim parameters than control eyes when measured with OCT. HRT measurements tended to be consistently lower in the C/D area ratio and cup area and higher in the rim area and rim volume than OCT measurements for both control eyes and eyes with BA. The intermethod discrepancy for all the parameters except the disc area was significantly larger in eyes with BA than in control eyes. Conclusion: The increased optic disc excavation was detected with OCT but not with HRT in CON eyes with BA of the optic disc. Thus, the distinct algorithms used by these two modalities affected the measurements of ONH parameters, particularly when assessing optic discs with temporal rim thinning.

    B M J PUBLISHING GROUP, Oct. 2008, BRITISH JOURNAL OF OPHTHALMOLOGY, 92 (10), 1382 - 1386, English

    [Refereed]

    Scientific journal

  • A. Nagai-Kusuhara, M. Nakamura, A. Kanamori, Y. Nakanishi, S. Kusuhara, Akira Negi

    Purpose To test whether Heidelberg Retina Tomograph (HRT) is applicable to assess the optic nerve head (ONH) configuration of the atrophic phase of non-glaucomatous optic neuropathy when a default set of the reference plane is used. Methods Ten eyes with non-arteritic anterior ischaemic optic neuropathy (NAION), 17 eyes with Leber's hereditary optic neuropathy (LHON), 40 eyes with compressive optic neuropathy (CON) owing to chiasmal tumour, and 241 eyes of control individuals were examined with HRT using the default reference plane. The global values of HRT parameters were evaluated among the groups of patients and controls. The sectoral measurements of the eyes with LHON and CON were compared with controls. To eliminate the influence of disc size and age on HRT measurements, eyes with disc area-and age-matched normal controls were used for comparison with eyes with NAION and LHON. Results Cup parameters in eyes with NAION were similar to those in controls. The retinal nerve fibre layer (RNFL) thickness was significantly thinner in eyes with NAION than that of controls. The eyes with LHON had significantly larger cup parameters, smaller rim volume, and thinner mean RNFL thickness than controls. Eyes with CON had significantly larger rim area and smaller cup parameters but similar RNFL thickness compared with controls. Conclusions When the default reference plane is used, HRT can measure the ONH configuration in eyes with NAION and LHON as expected. However, caution must be made to interpret the parameters obtained from the eyes with CON.

    NATURE PUBLISHING GROUP, Sep. 2008, EYE, 22 (9), 1154 - 1160, English

    [Refereed]

    Scientific journal

  • 異なる手術術式を選択した高度近視に伴う進行性内斜視の母子例

    Yamada Yuko

    Mar. 2008, 眼科臨床紀要, 1巻, 3号, pp. 270-271, Japanese

    International conference proceedings

  • Oxidized low density lipoproteins induce a pathologic response by retinal pigmented epithelial cells

    Yamada Yuko

    Jan. 2008, Journal Of Neurochemistry, Vol. 105, No. 4, pp. 1187-97, English

    Scientific journal

  • Y Tatsumi, A Kanamori, A Kusuhara, Y Nakanishi, S Kusuhara, M Nakamura

    Background: Optic tract syndrome (OTS) is characterized by incongruous homonymous hemianopia and a perpendicular pattern of bilateral optic atrophy due to the optic tract lesion. However, loss of retinal nerve fiber layer thickness (RNFLT) associated with OTS has not been quantitatively assessed. Case: A 20-year-old woman with blunt head trauma showed normal visual acuity, color vision, ocular motility, and intraocular pressure. Because of a relative afferent pupillary defect in her left eve and left-sided homonymous hemianopia, we suspected right-sided optic tract damage, although magnetic resonance imaging detected no intracranial lesion. Observations: Using optical coherence tomography (OCT), the RNFLT of this case was measured at 31 months after the trauma and compared with age-matched normal controls (n = 41). Nasal, temporal, superior, and inferior quadrant RNFLT was reduced by 22%, 21%, 5%, and 46% in the right eye and 76%, 64%, 25%, and 27% in the left eve, respectively. The reduction was > 3 x the standard deviation of the normal mean values in the nasal and temporal quadrants of the left eve and in the inferior quadrant of the right eye. Conclusions: OCT can determine the RNFLT reduction corresponding to the characteristic patterns of optic atrophy of OTS.

    ELSEVIER SCIENCE INC, Jul. 2005, JAPANESE JOURNAL OF OPHTHALMOLOGY, 49 (4), 294 - 296, English

    Scientific journal

  • A Kanamori, M Nakamura, Y Nakanishi, Y Yamada, A Negi

    Although glaucoma is known to alter glial reactivity, the long-term effect of elevated intraocular pressure (IOP) on glial change has not been fully elucidated. This study aimed to examine how chronically elevated IOP induced by episcleral vein cauterization (EVC) in unilateral eyes affect reactivities of astrocytes and Muller cells of rats in the treated as well as contralateral eyes over time. EVC in unilateral eyes of Sprague-Dawley rats were performed to produce chronically elevated IOP. Flat mounted retina preparations were made at several points until 6 months, which were subjected to immunostaining for glial fibrillary acidic protein (GFAP). Retinal homogenates were one- or two-dimensionally electrophoresed, followed by GFAP immunoblotting. EVC significantly increased IOPs up to 27.8 from 13.1 mmHg, which gradually decreased over time. In flat mounted retinas, astrocytes lost but Muller cells gained GFAP immunoreactivity at 3 days after cauterization. The glial changes were partially reversed over time but last even after IOP normalization. In the contralateral eyes, similar glial changes gradually appeared at 1 month after EVC and thereafter. Immunoblotting demonstrated not only molecular size shifts but also alteration of isoelectric focusing of GFAP both in treated and contralateral retina as compared with age-matched control retina. EVC led to opposite reactions in astrocytes and Muller cells in terms of GFAP immunoreactivity. Late-onset glial reactivity also occurred in the contralateral retina. (c) 2005 Elsevier Ltd. All rights reserved.

    ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, Jul. 2005, EXPERIMENTAL EYE RESEARCH, 81 (1), 48 - 56, English

    Scientific journal

  • A Kanamori, M Nakamura, N Matsui, A Nagai, Y Nakanishi, S Kusuhara, Y Yamada, A Negi

    Objectives: To analyze retinal nerve fiber layer (RNFL) thickness in eyes with band atrophy by use of optical coherence tomography (OCT) and to evaluate the ability of OCT to detect this characteristic pattern of RNFL loss. Design: Cross-sectional, retrospective study. Participants: Thirty-four eyes of 18 patients with bitemporal hemianopia caused by optic chiasm compression by chiasmal tumors were studied. All eyes were divided into 3 groups according to visual field loss grading after Goldmann perimetry. Interventions: Retinal nerve fiber layer thickness measurements with OCT. Main Outcome Measures: Retinal nerve fiber layer thickness around the optic disc was measured by OCT (3.4-mm diameter circle). Calculation of the changes in OCT parameters, including the horizontal (nasal + temporal quadrant RNFL thickness) and vertical values (superior + inferior quadrant RNFL thickness) was based on data from 160 normal eyes. Comparison between the 3 visual field grading groups was done with the analysis of variance test. The receiver operating characteristic (ROC) curve for the horizontal and vertical value were calculated, and the areas under the curve (AUC) were compared. Results: Retinal nerve fiber layer thickness in eyes with band atrophy decreased in all OCT parameters. The reduction rate in average and temporal RNFL thickness and horizontal value was correlated with visual field grading. The AUC of horizontal value was 0.970+/-0.011, which was significantly different from AUC of vertical value (0.903+/-0.022). Conclusions: The degree of RNFL thickness reduction correlated with that of visual field defects. Optical coherence tomography was able to identify the characteristic pattern of RNFL loss in these eyes. Ophthalmology 2004;111:2278-2283 (C) 2004 by the American Academy of Ophthalmology.

    ELSEVIER SCIENCE INC, Dec. 2004, OPHTHALMOLOGY, 111 (12), 2278 - 2283, English

    [Refereed]

    Scientific journal

  • A Kanamori, M Nakamura, Y Nakanishi, A Nagai, H Mukuno, Y Yamada, A Negi

    The Akt serine/threonine kinase mediates pro-survival signalings in retina and was reported to be activated in a response to some retinal and optic nerve injuries. Human and experimental glaucoma induce apoptosis of retinal ganglion cells (RGCs). The purpose of this study is to test whether episcleral vein cauterization (EVC) to chronically elevate intraocular pressures (IOPs) in rats increase apoptosis of RGCs and affect activation of Akt and its upstream insulin-like growth factor (IGF)-1 receptor/Insulin receptor. Three episcleral veins in left eyes of Sprague-Dawley rats were cauterized to elevate IOPs. Up to 6 months, IOPs were monitored and the retina was dissected at several time points. The numbers of terminal dUTP nick end labeling (TUNEL)-positive cells and those of RGCs labeled with fluorogold were counted in flat-mounted retina. Immunohistochemistry and immunoblotting were performed to identify cells expressing phosphorylated Akt and to quantify the phospho- to total ratios of Akt and IGF-1 receptor/insulin receptor. EVC significantly elevated ION up to 2 months, increased TUNEL-positive cells in an IOP-dependent fashion, and reduced 34.5% of RGCs at 6 months (P<0.001) compared with contralateral retinas. Phosphorylated Akt was specifically expressed in RGCs until 1 month after cauterization. Akt (P=0.036) and IGF-1 receptor/Insulin receptor (P=0.003) were transiently phosphorylated at 3 days. Intrinsic activation of the IGF-1 receptor/Insulin receptor to Akt pathway may occur in RGCs in retina with EVC. (C) 2004 Elsevier B.V. All rights reserved.

    ELSEVIER SCIENCE BV, Oct. 2004, BRAIN RESEARCH, 1022 (1-2), 195 - 204, English

    [Refereed]

    Scientific journal

  • 神経線維腫症に合併した先天緑内障の1例

    福村美帆, YAMADA, Yuko, KANAMORI,Akiyasu, 瀬谷隆, MATSUBARA,Satoshi, NAKAMURA, Makoto, NEGI, Akira

    Aug. 2004, 眼科臨床医報, 98巻, 8号, pp. 687-690, Japanese

    [Refereed]

    Scientific journal

  • 緑内障眼における上下半視野の網膜神経線維層厚の光干渉断層計による解析

    KANAMORI,Akiyasu, 瀬谷隆, YAMADA, Yuko, MATSUBARA,Satoshi, NAKAMURA, Makoto, NEGI, Akira

    Apr. 2004, 日本眼科学会雑誌, 108巻, 4, pp. 213-218, Japanese

    Scientific journal

  • 視神経疾患における乳頭周囲神経線維層厚と黄斑網膜厚の減少

    曽和 美幸, 楠原 仙太郎, 永井 あづさ, 中西 頼子, 金森 章泰, 山田 裕子, 中村 誠, 根木 昭, 関谷 善文

    日本神経眼科学会, Dec. 2003, 神経眼科, 20 (増補1), 43 - 43, Japanese

    [Refereed]

  • Band atrophyにおけるOCTによる網膜神経線維層厚の解析

    松井 敬子, 金森 章泰, 永井 あづさ, 中西 頼子, 楠原 仙太郎, 山田 裕子, 中村 誠, 関谷 善文, 根木 昭

    日本神経眼科学会, Dec. 2003, 神経眼科, 20 (増補1), 47 - 47, Japanese

    [Refereed]

  • 視索症候群の網膜神経線維層厚

    辰巳 康子, 金森 章泰, 中西 頼子, 永井 あづさ, 楠原 仙太郎, 山田 裕子, 中村 誠, 関谷 善文, 根木 昭

    日本神経眼科学会, Dec. 2003, 神経眼科, 20 (増補1), 79 - 79, Japanese

    [Refereed]

  • 動脈瘤性骨嚢胞の1例

    Yamada Yuko

    Feb. 2003, 眼科臨床医報, 97巻, 2号, pp. 132-132, Japanese

    International conference proceedings

  • Makoto Nakamura, Masumi Tanabe, Yuko Yamada, Atsushi Azumi

    PURPOSE: To report a case of zoster sine herpete with bilateral ocular involvement. METHOD: Case report. RESULTS: A 65-year-old man showed bilateral iridocyclitis with sectoral iris atrophy and elevated intraocular pressure unresponsive to steroid treatment. No cutaneous eruption was manifest on the forehead. A target region of varicella-zoster virus DNA sequence was amplified from the aqueous sample from the left eye by polymerase chain reaction. Bilateral iridocyclitis resolved promptly after initiation of systemic and topical acyclovir treatment. Secondary glaucoma was well controlled by bilateral trabeculectomy. CONCLUSIONS: Zoster sine herpete should be considered and polymerase chain reaction performed on an aqueous sample to detect varicella-zoster virus DNA for rapid diagnosis whenever anterior uveitis accompanies the characteristic iris atrophy, even in the case of bilateral involvement. © 2000 Elsevier Science Inc.

    2000, American Journal of Ophthalmology, 129 (6), 809 - 810, English

    [Refereed]

    Scientific journal

MISC

  • ランゲルハンス細胞組織球症による視神経症と外転神経麻痺を来した1例

    山田 裕子, 栗本 拓治, 盛 崇太朗, 坂本 麻里, 上田 香織, 中井 友昭, 魚住 洋一, 豊田 晶徳, 中西 裕子, 中村 誠

    日本神経眼科学会, Nov. 2018, 神経眼科, 35 (増補1), 84 - 84, Japanese

  • 【緑内障診療に役立つ検査ノウハウ】 ゴールドマン視野計

    Yamada Yuko

    Oct. 2017, OCULISTA, (55号), 55 - 65, Japanese

    Introduction commerce magazine

  • 視野異常を診断する 4. 遺伝性視神経症

    Yamada Yuko, 中村誠

    Dec. 2015, 眼科, 57 (13), 1653 - 1660, Japanese

    [Invited]

    Introduction scientific journal

  • 【緑内障なんでも質問箱-エキスパートに聞いたら最新エビデンスをもとにズバリと答えてくれた!】 治療編 手術 濾過手術 羊膜を用いたトラベクレクトミーのメリット・デメリットについて教えてください

    Yamada Yuko

    Oct. 2015, 臨床眼科, 69 (11号), 307 - 311, Japanese

    [Invited]

    Introduction scientific journal

  • 視神経乳頭腫脹を契機として発見された肺線癌の1例

    金井友範, 西崎雅也, Yamada Yuko, 金森斎修, 田邊益美, Kanamori Akiyasu, Nakamura Makoto

    Sep. 2015, 臨床眼科, 69 (9), 1395 - 1399, Japanese

    [Refereed]

    Report scientific journal

  • The Ability of SD-OCT to Differentiate Early Glaucoma in Highly Myopia from Highly Myopic Control

    Akiyasu Kanamori, Azusa Akashi, Kaori Ueda, Mari Sakamoto, Yukako Inoue, Yuko Yamada, Makoto Nakamura

    ASSOC RESEARCH VISION OPHTHALMOLOGY INC, Jun. 2015, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 56 (7), English

    Summary international conference

  • The OCT findings of macula and associated factors in patients with a history of retinopathy of prematurity

    Akiko Miki, Shigeru Honda, Yoshiko Matsumoto, Azusa Akashi, Yuko Yamada, Makoto Nakamura

    ASSOC RESEARCH VISION OPHTHALMOLOGY INC, Jun. 2015, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 56 (7), English

    Summary international conference

  • Trabeculotomy with Schlemm's canal endothelium removal and deep sclerectomy

    Eriko Yasuda, Akiyasu Kanamori, Kaori Ueda, Azusa Akashi, Yukako Inoue, Yuko Yamada, Makoto Nakamura

    ASSOC RESEARCH VISION OPHTHALMOLOGY INC, Jun. 2015, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 56 (7), English

    Summary international conference

  • 【エキスパートからノウハウを学ぶ!弱視・斜視スペシャルノート[疾患と治療編]】 弱視の治療

    Yamada Yuko

    Oct. 2014, 眼科ケア, 16 (10号), 924 - 930, Japanese

    Introduction scientific journal

  • 視神経疾患の新しい展開

    根木 昭, 中村 誠, 金森 章泰, 楠原 あづさ, 中西 頼子, 辰巳 康子, 藤岡 美幸, 田口 真衣子, 福田 昌秀, 田渕 久美子, 三木 明子, 溝上 淳二, 長井 隆行, 藤原 雅史, Yamada Yuko

    光干渉断層計(optical coherence tomography:OCT)は眼科学に生体病理学ともいえる新しい分野を形成し,黄斑疾患や緑内障の診療に革新的な情報をもたらしている.緑内障の診断には他の視神経・視路疾患との鑑別が必要である.そこでOCTの視神経・視路疾患における有用性について検討した.次いで,視神経疾患の中で最も頻度の高い緑内障性視神経症(glaucomatous optic neuropathy:GON)の病態についてアクアポリン(aquaporin:AQP)の動態に焦点を当てて検討した.I 光干渉断層計による視神経・視路疾患の評価 交互点滅対光反射試験(swinging flashlight test)は相対的瞳孔求心路障害(relative afferent pupillary defect:RAPD)を検出する容易で敏感な他覚的検査である.片眼性視神経萎縮20症例でswinging flashlight testにおけるRAPD量とOCTで測定した網膜神経線維層厚(retinal nerve fiber layer thickness:RNFLT)の両眼間の比には有意の相関がみられた.OCTによりRAPDという両眼の視神経機能障害の差を,構造的な差として把握することができた.外傷性視神経症4例において受傷直後よりRNFLTおよび神経節細胞複合体(ganglion cell complex:GCC)の経時変化を観察した.OCTによりRNFLT,GCCは受傷後2週から20週の間に急速に減少することが分かった.視交叉症候群34眼でRNFLTを測定すると,視神経乳頭周囲の水平方向では垂直方向に比してRNFLTは有意に減少していた.このことは視交叉症候群にみられる視神経乳頭の帯状萎縮が,OCTにより量的に把握できることを示した.視索症候群でRNFLTを測定すると,患側では視神経乳頭の垂直方向の水平方向に対する菲薄化が,対側では水平方向の垂直方向に対する菲薄化が確認された.またGCCでは患側の中心窩から耳側半側の菲薄化,対側眼では鼻側半側の菲薄化を示した.これらは視索症候群における患側視神経乳頭の砂時計状萎縮,対側における帯状萎縮,また同名半盲を構造的に捉えていることを示す.OCTはこのように視神経・視路疾患の評価にも有用であったが,限界もある.視交叉症候群ではOPTvue 100とCirrusで測定したRNFLTの非薄部位はまったく逆の結果を示した.これはRTVue 100のほうがCirrusに比較して視神経乳頭鼻側の薄いRNFL評価に優れているためであった.OCTの評価には機種の特性を考慮する必要がある.II 視神経におけるアクアポリンの動態 AQPは細胞膜を水が効率よく通過できるための水チャンネルを構成する膜蛋白質である.従来,視神経にはAQP-4が発現していることが報告されていたが,AQP-4は球後の有髄神経部位にのみ発現し,視神経乳頭に発現するAQPについては不明であった.我々はラット,サル,ヒトで視神経におけるAQPの発現を検討した.無髄神経部位の前篩状板部,篩状板部ではAQP-9のみが発現し,有髄神経部位ではAQP-4とAQP-9が発現していることを認めた.これらはglial fibrillary acidic proteinと共発現したことから,アストロサイトに発現していることが分かった.ラットにおいて高眼圧眼を作製するとAQP-4の発現は変化がなかったが,AQP-9の発現は著明に減少した.この現象はサル高眼圧眼,ヒト緑内障眼でも同様であった.AQP-9は水のほか,乳酸などの溶質も輸送するアクアグリセロポリンに属する.近年,神経科学の分野ではアストロサイトから神経細胞への乳酸の輸送が神経細胞のエネルギー基質になっているというastrocyte-to-neuron lactate shuttle hypothesisが提唱されている.眼圧上昇による視神経乳頭におけるAQP-9の発現低下はGONの発症に深くかかわっている可能性がある.(著者抄録)

    (公財)日本眼科学会, Mar. 2013, 日本眼科学会雑誌, 117 (3), 187 - 211, Japanese

    Introduction scientific journal

  • 緑内障3分診療を科学する! 乳頭の脆弱性 血管系と「100日」

    Yamada Yuko

    Oct. 2012, 眼科, 54 (11号), 1654 - 1658, Japanese

    Introduction scientific journal

  • 目でみるシリーズ 続・読影シリーズ(第5回) 紛らわしい例(その2) 眼底の異常(血管異常を含む)を伴う例

    Yamada Yuko

    Sep. 2012, Frontiers in Glaucoma, (44号), 109 - 116, Japanese

    Introduction scientific journal

  • 災害時における緑内障診療

    Negi Akira, Yamada Yuko

    Sep. 2012, Frontiers in Glaucoma, (44号), 126 - 134, Japanese

    Others

  • 【基礎知識がバッチリ!実践でそのまま役立つ斜視・弱視の原因、検査、治療】 病気について知ろう 弱視ってどんな病気?

    Yamada Yuko

    Aug. 2012, 眼科ケア, 14 (8号), 704 - 708, Japanese

    Introduction scientific journal

  • 緑内障研究の進歩 緑内障性視神経症への挑戦 新しい病態論の提唱と他覚的機能解析方法の改良

    Nakamura Makoto, Naka Maiko, Nagai Takayuki, Kanamori Akiyasu, Yamada Yuko, Negi Akira

    緑内障性視神経症は緑内障における視機能障害の本態とされる.しかし,眼圧を筆頭とするさまざまな危険因子がどのようにして緑内障性視神経症を引き起こすのか,未だ十分に解明されていない.また,視機能障害の評価に用いられる静的・動的視野検査は心理物理学に基づく自覚的検査であるため,客観的な他覚的検査法の導入が望まれてきた.本研究において我々は緑内障性視神経症の病態と他覚的視機能解析方法に関して検討を行った.アクアポリン(aquaporin:AQP)水チャンネルは,ホモないしヘテロ四量体として主に細胞膜に存在し,細胞内外への双方向性の水輸送を担っている.AQPによる水輸送は,神経細胞が活動電位を迅速に繰り返し発生させるのに不可欠である.既報の13のアイソフォームのうちAQP-4が球後視神経には発現するが,視神経乳頭部には発現していないことが知られていた.我々は,ラット視神経のアストロサイトは,無髄・有髄領域にかかわらずAQP-9を発現していることを見出した.上強膜静脈焼灼による慢性高眼圧によって,AQP-9の免疫染色性と遺伝子発現が著しく減弱したが,球後のAQP-4の発現に変化はなかった.同様の変化は,隅角レーザー誘発高眼圧サル眼やヒト緑内障眼の視神経でも確認された.さらにAQP-9は正常ラットでは網膜神経節細胞の細胞体にも発現していたが,慢性高眼圧眼ではその発現が有意に減弱していた.すなわち,慢性高眼圧は,視神経乳頭のアストロサイトと網膜神経節細胞の細胞体という,緑内障性視神経症の発症に深く関与している細胞ならびに部位におけるAQP-9の発現を減弱させていた.近年,神経科学の分野では,解糖系によりブドウ糖から代謝されて産生された乳酸がエネルギー基質としてアストロサイトから神経細胞へ供給されると考えられるようになった(astrocyte-to-neuron lactate shuttle hypothesis).AQP-9は,水以外に乳酸などの溶質も輸送するアクアグリセロポリンに属する.AQP-9のdown-regulationにより,エネルギー基質である乳酸が網膜神経節細胞とその軸索へ正常に供給されなくなることが,緑内障性視神経症の発症に関与している可能性がある.多局所視覚誘発電位(multifocal visual evoked potential:mfVEP)は一度に60ヶ所の局所網膜に対応する視覚誘発電位を記録することのできる他覚的視野検査である.同時に複数のチャンネルから記録することで,信号雑音比(signal-to-noise ratio:SNR)は向上した.しかし,これまでの研究対象はおおむね白人であったため,骨格の異なる日本人に適した記録方法はまだ確立されていなかった.200例の頭部磁気共鳴画像(magnetic resonance imaging:MRI)から鳥距溝の後頭結節に対する相対位置関係を計測したところ,白人に比べ,その相対位置関係は約1cm有意に低かった.次いで,3チャンネルからのmfVEP同時記録ならびに信号窓と雑音窓におけるSNR分布の受信者操作特性(receiver-operating characteristic:ROC)曲線解析を行った.その結果,日本人においては,後頭結節を挟む水平チャンネルと二組の垂直チャンネルのいずれかを組み合わせた2チャンネルを用いてmfVEP記録すると,ROC曲線下面積(area under the ROC curve:AUC)が最も大きくなることを見出した.次にHumphrey視野計の平均偏差が-15dB未満の初期から中期緑内障56眼ならびに正常62眼において,このSNR-AUCがHumphrey視野計のトータル偏差に対して,同等の緑内障診断能ならびに高い相関を示すことを見出した.一方,確率プロットに基づく,Humphrey視野とmfVEP間の障害部位のトポグラフィカルな一致率は中程度であった.従来検討されてきたSNRの確率プロットのクラスター判定が局所の感度低下の診断に有用であるのに対して,SNR-AUCは,平均偏差に類似した,緑内障性視神経症のびまん性機能障害を定量するグローバル・インデックスとして用いることができる可能性がある.(著者抄録)

    (公財)日本眼科学会, Mar. 2012, 日本眼科学会雑誌, 116 (3), 298 - 346, Japanese

    [Refereed][Invited]

    Introduction scientific journal

  • 緑内障セミナー 羊膜移植併用緑内障手術

    Yamada Yuko

    Jun. 2011, あたらしい眼科, 28巻, 6号, pp. 827-828, Japanese

    Introduction scientific journal

  • 【不定愁訴の子どもを診るために】 症状に応じたアプローチ 目が見えない(視覚障害)

    Yamada Yuko

    Jan. 2011, 小児科診療, 74巻, 1号, pp. 68-74, Japanese

    Others

  • 【覚えておきたい! 眼圧検査で異常値が出る原因】 高眼圧の原因

    Yamada Yuko

    Jul. 2010, 眼科ケア, 12巻, 7号, pp. 654-662, Japanese

    Others

  • 目で見るシリーズ 読影シリーズ まぎらわしい例(その2) 血管異常を含む眼底異常に伴う例

    Yamada Yuko

    Dec. 2009, Frontiers in Glaucoma, 10巻, 3号, pp. 101-105, Japanese

    Introduction scientific journal

  • 【目の病気における看護ケアのポイント 入院治療を要する重症眼疾患を対象に】 知っておきたい知識 先天性眼疾患 先天白内障、発達緑内障、眼瞼下垂

    Yamada Yuko

    Dec. 2008, 小児看護, 31巻, 13号, pp. 1734-1739, Japanese

    Others

  • 【患児と親へのよりよい対応のために子どもの目の病気とケア】 実践編 子どもの検査をマスターしよう 形態評価

    Yamada Yuko

    Jun. 2007, 眼科ケア, 巻, 2007夏季増刊, pp. 210-225, Japanese

    Others

  • 【緑内障の患者説明 正しい知識を伝えるための3ステップ】 疾患・検査・治療についての正しい知識を身に付ける! 緑内障ではこんな治療を行う

    Yamada Yuko

    Feb. 2007, 眼科ケア, 9巻, 2号, pp. 154-164, Japanese

    Others

  • S. Kusuhara, M. Nakamura, A. Nagai-Kusuhara, Y. Nakanishi, A. Kanamori, A. Negi

    Aims To assess the changes in macular and peripapillary retinal nerve fibre layer (RNFL) thickness in eyes with unilateral optic atrophy and to evaluate the relationship between retinal thickness and visual function. Methods Enrolled were 22 patients with unilateral optic atrophy. Macular thickness at the divided nine areas and peripapillary RNFL thickness in quadrantic sections were measured by optical coherence tomography. Thickness values in the affected eyes were compared with those in the contralateral unaffected eyes. The correlation of foveal thickness with best-corrected visual acuity (BCVA) was evaluated. The correlation between retinal thickness and the remaining visual field area circumscribed with I-4-e isopter in superior and inferior hemifield was assessed. Results Macular thinning was observed in all areas (P < 0.001 in each area) other than the fovea (P=0.068). Peripapillary RNFL thickness decreased in all quadrantic sections (P < 0.001 in each section). The affected to unaffected eye ratio of retinal thickness was more than 0.6 in each area. BCVA did not correlate with foveal thickness (correlation coefficient 0.094, P=0.668). Although not statistically significant (P=0.281, superior hemifield; P=0.053, inferior hemifield), there was a tendency that eyes with severe visual field loss show more marked retinal thinning. Conclusions Macular thinning with the preserved foveal thickness is a hallmark of eyes with optic atrophy. Together with no correlation between foveal thickness and BCVA, this finding would help in differential diagnosis of macular and optic nerve diseases.

    NATURE PUBLISHING GROUP, Aug. 2006, EYE, 20 (8), 882 - 887, English

  • S Kusuhara, MFT Escano, S Fujii, Y Nakanishi, Y Tamura, A Nagai, H Yamamoto, Y Tsukahara, A Negi

    PURPOSE: To evaluate whether an index based on hole configuration can be used to predict visual outcome in eyes with idiopathic macular holes. DESIGN: Prospective interventional case series. METHODS: Thirty five eyes of 32 patients with idiom pathic stage 2 or 3 macular hole were enrolled in this study. The best-corrected visual acuity (BCVA), cross, sectional image of the macular hole by optical coherence tomography (OCT), and retinal thickness in the central ( < 1000 mum), inner (1000 to 2220 mum), and outer ring areas (2220 to 3450 mum) as defined by the OCT retinal mapping program were evaluated preoperatively and at 1, 3, 6, and 12 months postoperatively. The change in retinal thickness of the inner ring area at the 6,month postoperative period was used to evaluate the degree of preoperative retinal deformation. The macular hole index (MHI) (ratio of hole height to base diameter of hole) was calculated and correlated with minimum diameter of hole, base diameter of hole, the postoperative decrease in macular thickness, and the postoperative BCVA. The postoperative BCVA was further evaluated in two patient-matched groups. RESULTS: Retinal thickness values in the inner ring rea were decreased at the 1-month postoperative period. MHI significantly correlated with the postoperative de crease in macular thickness in the inner ring area at 6 months (correlation coefficient = -0.632, P = .030, Spearman analysis) and with the postoperative BCVA (P = .013, multiple regression analysis). Postoperative BCVA in the MHI greater than or equal to 0.5 group was better than that in the MHI < 0.5 group (P = .032, Mann,Whitney test). CONCLUSIONS: The MHI is a ratio easily calculated from OCT transverse images of the macular area. The MHI represents the preoperative configuration of a macular hole and is a prognostic factor for visual outcome. (C) 2004 by Elsevier Inc. All rights reserved.

    ELSEVIER SCIENCE INC, Nov. 2004, AMERICAN JOURNAL OF OPHTHALMOLOGY, 138 (5), 709 - 716, English

  • 小学校低学年児童の近視

    YAMADA, Yuko

    2004, 臨床眼科, 58巻, 2, pp. 125-129, Japanese

    Introduction scientific journal

  • 【眼科疾患別パーフェクト検査マニュアル】 疾患別検査の進め方 緑内障の検査

    YAMADA, Yuko, 調廣子

    Dec. 2003, 眼科ケア, 2003年冬季増刊, pp. 76-101, Japanese

    Others

Books etc

  • 眼疾患アトラスシリーズ第2巻 後眼部アトラス

    近藤, 峰生, 辻川, 明孝, 大鹿, 哲郎

    脳眼動静脈つた状血管腫症(Wyburn-Mason症候群), 総合医学社, Oct. 2019, Japanese, ISBN: 9784883786862

    Scholarly book

  • 眼疾患アトラスシリーズ第2巻 後眼部アトラス

    近藤, 峰生, 辻川, 明孝, 大鹿, 哲郎

    神経線維腫症(von Recklinghausen病), 総合医学社, Oct. 2019, Japanese, ISBN: 9784883786862

    Scholarly book

  • 眼疾患アトラスシリーズ第3巻 外眼部アトラス

    野田, 実香, 渡辺, 彰英, 大鹿, 哲郎

    部分調節性内斜視, 総合医学社, Oct. 2019, Japanese, ISBN: 9784883786879

    Scholarly book

  • 眼科検査ガイド第2版 / 9.視野検査 10)神経眼科疾患の視野検査 4.中心フリッカー値

    Yamada Yuko

    Others, 文光堂, Sep. 2016, Japanese

    Scholarly book

  • 眼科検査ガイド第2版 / 5.眼位・眼球運動検査 1)眼位検査 4.固視検査

    Yamada Yuko

    Others, 文光堂, Sep. 2016, Japanese

    Scholarly book

  • 眼科検査ガイド第2版 / 5.眼位・眼球運動検査 1)眼位検査 3.単眼性眼位検査

    Yamada Yuko

    Others, 文光堂, Sep. 2016, Japanese

    Scholarly book

  • 眼科検査ガイド第2版 / 5.眼位・眼球運動検査 1)眼位検査 2.眼位定量検査

    Yamada Yuko

    Others, 文光堂, Sep. 2016, Japanese

    Scholarly book

  • 眼科検査ガイド第2版 / 5.眼位・眼球運動検査 1)眼位検査 1.眼位定性検査

    Yamada Yuko

    Others, 文光堂, Sep. 2016, Japanese

    Scholarly book

  • 眼科臨床エキスパートシリーズ 緑内障治療のアップデート / 発達緑内障、小児続発緑内障

    Yamada Yuko

    Others, 医学書院, Oct. 2015, Japanese

    Scholarly book

  • 眼科臨床エキスパートシリーズ 緑内障治療のアップデート / 難治例の攻略法 小児緑内障

    Yamada Yuko

    Others, 医学書院, Oct. 2015, Japanese

    Scholarly book

  • 眼手術学 緑内障 / 小児の緑内障濾過手術

    Yamada Yuko

    Others, 文光堂, Jan. 2012, Japanese

    Scholarly book

  • 眼手術学 緑内障 / 小児の流出路再建術

    Yamada Yuko

    Others, 文光堂, Jan. 2012, Japanese

    Scholarly book

  • 眼科プラクティス / 【眼科薬物治療A to Z】 副作用と毒性 乳幼児・小児への投与時の注意点

    Yamada Yuko

    Joint work, 文光堂, Sep. 2008, Japanese

    Scholarly book

  • 眼科プラクティス / 【小児眼科診療】 疾患特性と診療指針 緑内障 発達緑内障

    Yamada Yuko

    Joint work, 文光堂, Mar. 2008, Japanese

    Scholarly book

  • Frontiers in Glaucoma 8巻4号 Page200-201 / 緑内障とは 眼の構造・機能

    Yamada Yuko

    Joint work, メディカルレビュー社, Dec. 2007, Japanese

    Scholarly book

  • 眼科プラクティス / 【緑内障診療の進めかた】 基礎知識 無作為化比較試験から得たエビデンス EGPS

    Yamada Yuko

    Joint work, 文光堂, Sep. 2006, Japanese

    Scholarly book

  • 小児眼科・診療の最前線 / 大脳皮質一次視覚野の可塑性

    Yamada Yuko

    Joint work, 金原出版, Apr. 2003, Japanese

    Scholarly book

  • 先端医療シリーズ23眼科 眼科の最新医療 / 白内障手術の進歩 8 小児IOL

    YAMADA, Yuko

    Joint work, 先端技術研究所, 2003, Japanese

    Scholarly book

  • 先端医療シリーズ23眼科 眼科の最新医療 / 白内障手術の進歩 8 小児IOL

    Yamada Yuko

    Joint work, 先端医療技術研究所, 2003, Japanese

    Scholarly book

  • 眼科ケア2003冬季増刊 眼科疾患別パーフェクトマニュアル / 緑内障検査

    YAMADA, Yuko, 調 廣子

    Joint work, メディカ出版, 2003, Japanese

    Scholarly book

  • 改訂第3版眼科ナースのための知識と実際 / 小児眼疾患と看護

    YAMADA, Yuko

    Joint work, メディカ出版, 2003, Japanese

    Scholarly book

Presentations

  • 緑内障手術 ~神戸大学における現状と課題~

    中西(山田) 裕子

    東灘区眼科講演&甲南医療センター眼科 病診連携の会, 14 Dec. 2019, Japanese, Domestic conference

    Public discourse

  • 両眼開放下視野測定により診断した片眼性心因性視覚障害の2例

    土橋 一生, 盛 崇太朗, 中西 裕子, 上田 香織, 坂本 麻里, 栗本 拓治, 中村 誠

    兵庫県眼科医会・2大学合同オープンカンファレンス, 30 Nov. 2019, Japanese, Domestic conference

    Oral presentation

  • 毛様溝挿入バルベルトインプラント手術の中長期成績

    曽谷 尭之, 盛 崇太朗, 村井 佑輔, 上田 香織, 坂本 麻里, 栗本 拓治, 中西 裕子, 中村 誠

    兵庫県眼科医会・2大学合同オープンカンファレンス, 30 Nov. 2019, Japanese, Domestic conference

    Oral presentation

  • 緑膿菌が原因の結膜炎から結膜欠損を引き起こした免疫健常な若年例

    山田 裕子, 上田 香織, 長井 隆行, 中西 裕子, 中村 誠

    第73回日本臨床眼科学会, 24 Oct. 2019, Japanese, Domestic conference

    Poster presentation

  • 毛様溝挿入バルベルトインプラント手術の術後中長期成績

    曽谷 尭之, 盛 崇太朗, 村井 佑輔, 上田 香織, 坂本 麻里, 栗本 拓治, 中西 裕子, 中村 誠

    第73回日本臨床眼科学会, 24 Oct. 2019, Japanese, Domestic conference

    Oral presentation

  • 多発血管炎性肉芽腫症に伴う副鼻腔炎により発症した両側鼻性視神経症の一例

    村井 佑輔, 栗本 拓治, 河原 佳奈, 山田 裕子, 盛 崇太朗, 上田 香織, 坂本 麻里, 中西 裕子, 中村 誠

    第57回日本神経眼科学会総会, 05 Oct. 2019, Japanese, Domestic conference

    Oral presentation

  • 抗PD-L1抗体薬により視神経炎と下垂体機能低下症を来した一例

    山田 裕子, 栗本 拓治, 上田 香織, 村井 佑輔, 盛 崇太朗, 坂本 麻里, 中西 裕子, 中村 誠

    第57回日本神経眼科学会総会, 04 Oct. 2019, Japanese, Domestic conference

    Poster presentation

  • 再発性視神経炎に対する免疫抑制剤の治療効果

    盛 崇太朗, 栗本 拓治, 村井 佑輔, 上田 香織, 坂本 麻里, 千原 典夫, 中西 裕子, 中村 誠

    第57回日本神経眼科学会総会, 04 Oct. 2019, Japanese

    Oral presentation

  • 教育講演2【緑内障病型ごとのアプローチ】小児緑内障へのアプローチ

    中西 裕子

    第30回日本緑内障学会, 06 Sep. 2019, Japanese, Domestic conference

    Oral presentation

  • 毛様溝挿入アーメドインプラント手術の術後短期成績

    村井 佑輔, 盛 崇太朗, 栗本 拓治, 山田 裕子, 上田 香織, 坂本 麻里, 中西 裕子, 中村 誠

    第30回日本緑内障学会, 06 Sep. 2019, Japanese, Domestic conference

    Oral presentation

  • En face slab imaging を用いた後期緑内障眼の構造と機能の解析

    坂本 麻里, 盛 崇太, 上田 香織, 栗本 拓治, 中西 裕子, 中村 誠

    第8回日本視野画像学会学術集会, 19 May 2019, Japanese

    Oral presentation

  • 小児眼科 Q&A

    中西(山田) 裕子

    第4回 瓜坊の会, 17 May 2019, Japanese, Domestic conference

    Public discourse

  • OCTによる上方視神経部分低形成の診断の試み

    金森 章泰, 若林 星太, 金森 敬子, 盛 崇太朗, 栗本 拓治, 中西 裕子, 中村 誠

    第123回日本眼科学会総会, 18 Apr. 2019, Japanese, Domestic conference

    Oral presentation

  • マイクロパルス波経強膜毛様体光凝固の使用経験

    村井 佑輔, 盛 崇太朗, 上田 香織, 坂本 麻里, 栗本 拓治, 中西 裕子, 中村 誠

    第123回日本眼科学会総会, 18 Apr. 2019, Japanese, Domestic conference

    Poster presentation

  • 片眼の動眼神経麻痺と僚眼の外転神経麻痺を呈したサルコイドーシスの1例

    盛 崇太朗, SAKAMOTO MARI, 上田 香織, KURIMOTO TAKUJI, NAKANISHI YUKO, NAKAMURA MAKOTO

    第56回日本神経眼科学会総会, Dec. 2018, Japanese, 神戸, Domestic conference

    Oral presentation

  • 髄膜炎を伴う続発性眼窩炎症と強膜炎を呈した汎発性帯状疱疹の一例

    佐々木 信之, SAKAMOTO MARI, KURIMOTO TAKUJI, 盛 崇太朗, 上田 香織, NAKANISHI YUKO, 飯島 健太, 立花久嗣, NAKAMURA MAKOTO

    第56回日本神経眼科学会総会, Dec. 2018, Japanese, 神戸, Domestic conference

    Oral presentation

  • 髄膜炎を伴う続発性眼窩炎症と強膜炎を呈した汎発性帯状疱疹の一例

    佐々木 信之, SAKAMOTO MARI, KURIMOTO TAKUJI, 盛 崇太朗, 上田 香織, NAKANISHI YUKO, 飯島 健太, 立花 久嗣, NAKAMURA MAKOTO

    第5回神戸大学眼科オープンカンファレンス, Nov. 2018, Japanese, 神戸, Domestic conference

    Oral presentation

  • ランゲルハンス細胞組織球症による視神経症と外転神経麻痺を来した 1 例

    山田 裕子, KURIMOTO TAKUJI, 盛 崇太朗, SAKAMOTO MARI, 上田 香織, 芥子 結香子, 中井 友昭, 魚住 洋一, 豊田 晶徳, NAKANISHI YUKO, NAKAMURA MAKOTO

    第5回神戸大学眼科オープンカンファレンス, Nov. 2018, Japanese, 神戸, Domestic conference

    Oral presentation

  • サイトメガロウイルス虹彩炎に起因する続発性緑内障 15 例の臨床像

    村井 佑輔, 盛 崇太朗, SAKAMOTO MARI, 上田 香織, 芥子 結香子, KURIMOTO TAKUJI, KUSUHARA SENTARO, NAKANISHI YUKO, NAKAMURA MAKOTO

    第5回神戸大学眼科オープンカンファレンス, Nov. 2018, Japanese, 神戸, Domestic conference

    Oral presentation

  • Agreement of a nasal step border by a microperimeter with a temporal raphe by optical coherence tomography in glaucoma patients

    Sotaro Mori, Mari Sakamoto, Takuji Kurimoto, Kaori Ueda, Yuko Nakanishi, Makoto Nakamura

    23rd International visual field and imaging symposium, May 2018, English, 石川, Domestic conference

    Poster presentation

  • SD-OCTによる黄斑部解析の視交叉圧迫性視神経症の検出力

    Kanamori Akiyasu, 河賀 友紀, 島脇 由香, 明石 梓, 松本 佳子, 坂本 麻里, 近藤 陽子, Yamada Yuko, Nakamura Makoto

    The 67th Annual Congress of Japan Clinical Ophthalmology, Oct. 2013, Japanese, Japanese Ophthalmological Society, 横浜, Domestic conference

    Oral presentation

  • SD-OCTによる黄斑部解析での 菲薄化プロットパターンによる初期緑内障眼検出能

    中 真衣子, Kanamori Akiyasu, 明石 梓, 冨岡 真理, 坂本 麻里, Fujihara Masashi, Yamada Yuko, Nakamura Makoto

    The 67th Annual Congress of Japan Clinical Ophthalmology, Oct. 2013, Japanese, Japanese Ophthalmological Society, 横浜, Domestic conference

    Oral presentation

  • 3種のSD-OCTの黄斑部パラメータと視野の相関

    冨岡 真里, Kanamori Akiyasu, 河賀 友紀, 島脇 由香, 明石 梓, Fujihara Masashi, Yamada Yuko, Nakamura Makoto

    The 24rd Meeting of Japan Glaucoma Society, Sep. 2013, Japanese, Japan Glaucoma Society, 東京, Domestic conference

    Oral presentation

  • Comparative assessment for the ability of macular parameters and circumpapillary retinal nerve fiber layer measured by three spectral-domain optical coherence tomograpahy insrtuments to diagnose glaucoma with high myopia

    明石 梓, Kanamori Akiyasu, Nakamura Makoto, Fujihara Masashi, Yamada Yuko, Negi Akira

    ARVO2012, May 2013, English, The Association For Research in Vision and Ophthalmology, Seattle, USA, International conference

    Oral presentation

  • 3種のSD-OCTの乳頭周囲網膜神経線維層と視野の相関

    明石 梓, Kanamori Akiyasu, 坂本 麻里, Fujihara Masashi, Yamada Yuko, Nakamura Makoto, Negi Akira

    The 117th Annual Meeting of Japanese Ophthalmological Society, Apr. 2013, Japanese, Japanese Ophthalmological Society, 東京, Domestic conference

    Oral presentation

  • 小脳髄膜腫より腫瘍随伴性視神経症を発症した1例

    中野 沙弥, Kanamori Akiyasu, Yamada Yuko, Nakamura Makoto, Mizukawa Katsu, Negi Akira

    JANOS2012, Nov. 2012, Japanese, Japanese Neuro-ophthalmology Society, 京都, Domestic conference

    Oral presentation

  • Spectral-domain OCTを用いたSSOHの網膜内構造の評価

    大西 健, Kanamori Akiyasu, Yamada Yuko, Nakamura Makoto, Negi Akira

    JANOS2012, Nov. 2012, Japanese, Japanese Neuro-ophthalmology Society, 京都, Domestic conference

    Oral presentation

  • 3種の光干渉断層計で測定した高眼圧症,Pre-perimetric glaucomaにおける視神経乳頭周囲網膜神経層厚の比較

    明石 梓, Kanamori Akiyasu, 坂本 麻里, Fujihara Masashi, Yamada Yuko, Nakamura Makoto, Negi Akira

    The 66th Annual Congress of Japan Clinical Ophthalmology, Oct. 2012, Japanese, Japanese Ophthalmological Society, 京都, Domestic conference

    Oral presentation

  • 小児緑内障における治療とその選択

    Yamada Yuko

    The 23rd Meeting of Japan Glaucoma Society, Sep. 2012, Japanese, Japan Glaucoma Society, 金沢, Domestic conference

    Public symposium

  • 自己眼圧測定器IcareONE®の精度および安全性の検討

    坂本 麻里, Kanamori Akiyasu, 明石 梓, Fujihara Masashi, Yamada Yuko, Nakamura Makoto, Negi Akira

    The 23rd Meeting of Japan Glaucoma Society, Sep. 2012, Japanese, Japan Glaucoma Society, 金沢, Domestic conference

    Oral presentation

  • ロジスティック回帰分析による線維柱帯切除術後の低眼圧黄斑症寄与因子の検討

    松本 佳子, Fujihara Masashi, Kanamori Akiyasu, Yamada Yuko, Nakamura Makoto, Negi Akira

    The 23rd Meeting of Japan Glaucoma Society, Sep. 2012, Japanese, Japan Glaucoma Society, 金沢, Domestic conference

    Oral presentation

  • 3種のOCTによる高度近視群、非高度近視群における緑内障検出力の比較

    明石 梓, Kanamori Akiyasu, 坂本 麻里, Fujihara Masashi, Yamada Yuko, Nakamura Makoto, Negi Akira

    The 23rd Meeting of Japan Glaucoma Society, Sep. 2012, Japanese, Japan Glaucoma Society, 金沢, Domestic conference

    Oral presentation

  • 長期経過において形態変化を認めた網膜つた状血管腫の一例

    Miki Akiko, Yamada Yuko, Kanamori Akiyasu, Nakamura Makoto, Negi Akira

    JASA2012, Jun. 2012, Japanese, Japanese Association of Strabismus and Amblyopia, 名古屋, Domestic conference

    Oral presentation

  • 外傷性視神経症における網膜神経線維層厚およびGanglion cell complexの経時的変化

    Kanamori Akiyasu, 田渕 久美子, 近藤 陽子, Yamada Yuko, Nakamura Makoto, Negi Akira

    The 116th Annual Meeting of Japanese Ophthalmological Society, Apr. 2012, Japanese, Japanese Ophthalmological Society, 東京, Domestic conference

    Oral presentation

  • 「緑内障3分診療を科学する!」視神経乳頭の脆弱性:血管系と「100日」

    Yamada Yuko

    The 116th Annual Meeting of Japanese Ophthalmological Society, Apr. 2012, Japanese, Japanese Ophthalmological Society, 東京, Domestic conference

    Public discourse

  • Differential diagnosis of pediatric glaucoma

    Yamada Yuko

    The 27th APAO/SOE Congress, Apr. 2012, English, The Korean Ophthalmological Society, Busan,Korea, International conference

    Oral presentation

  • 二種のスペクトラル・ドメイン光干渉断層計のband atrophy検出能と一致性の検討

    Nakamura Makoto, 田渕 久美子, Kanamori Akiyasu, Yamada Yuko

    第49回日本神経眼科学会, Nov. 2011, Japanese, 兵庫医科大学, 神戸, Domestic conference

    Oral presentation

  • 3種の光干渉断層計で測定した視神経乳頭線維層の緑内障検出能の比較検討

    Kanamori Akiyasu, 冨岡 真里, 河賀 友紀, 田渕 久美子, Yamada Yuko, Nakamura Makoto, Negi Akira

    第65回日本臨床眼科学会, Oct. 2011, Japanese, 日本大学, 東京, Domestic conference

    Oral presentation

  • 3種のスペクトラルドメイン光干渉断層計による視神経乳頭周囲網膜神経層厚の相関と一致性

    河賀 友紀, 冨岡 真里, 石川 久美子, Kanamori Akiyasu, Yamada Yuko, Nakamura Makoto, Negi Akira

    第22回日本緑内障学会, Sep. 2011, Japanese, 日本緑内障学会, 秋田, Domestic conference

    Oral presentation

  • Differences in filtering bleb structure associated with long-term intraocular pressure control between trabeculectomy with and without amniotic membrane transplantation.

    Nakamura Makoto, 中 真衣子, Yamada Yuko, Negi Akira

    世界緑内障会議, Jun. 2011, English, World Glaucoma Association, パリ, フランス, International conference

    Oral presentation

  • A comparison of long-term outcomes between trabeculectomy with and without amniotic membrane transplantation for intractable glaucoma

    Yamada Yuko, Nakamura Makoto, Negi Akira

    世界緑内障会議, Jun. 2011, English, World Glaucoma Association, パリ, フランス, International conference

    Oral presentation

  • 補助材料(薬剤)を利用した緑内障手術 羊膜移植を用いた緑内障手術

    Yamada Yuko

    第21回日本緑内障学会, Sep. 2010, Japanese, 日本緑内障学会, 福岡, Domestic conference

    Oral presentation

  • 小児緑内障難治例に対する羊膜移植併用線維柱帯切除術の術後経過について

    Yamada Yuko, Nakamura Makoto, 石川 久美子, 溝上 淳二, Negi Akira

    第66回日本弱視斜視学会総会・第35回日本小児眼科学会総会合同学会, Jul. 2010, Japanese, 日本斜視弱視学会・日本小児眼科学会, 東京, Domestic conference

    Oral presentation

  • A phase I study of sorafenib (BAY 43-9006) in combination with S-1 plus cisplatin in patients with advanced gastric cancer.

    Yamada Yuko, Minami Hironobu, Fuse N, Ohtsu A, kato K, Kiyota Naomi, Shimada Y, Doi T, Nakajima T, Hamaguchi T, Fujiwara Y, Itoh Y, Mera K

    21st EORTH-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, Nov. 2009, English, AACR, Boston, 米国, International conference

    Poster presentation

  • 羊膜移植併用濾過手術の術後短期成績

    永井 あづさ, KANAMORI,Akiyasu, YAMADA, Yuko, MATSUBARA,Satoshi, NAKAMURA, Makoto, NEGI, Akira

    第27回日本眼科手術学会総会, Jan. 2004, Japanese, 日本眼科手術学会, 東京, Domestic conference

    Oral presentation

  • 視神経疾患における乳頭周囲神経線維層厚と黄斑網膜厚の減少

    曽和 美幸, KUSUHARA, Sentaro, 永井 あづさ, 中西 頼子, KANAMORI,Akiyasu, YAMADA, Yuko, NAKAMURA, Makoto, NEGI, Akira, SEKIYA,Yoshibumi

    第41回日本神経眼科学会, Dec. 2003, Japanese, 日本神経眼科学会, 京都, Domestic conference

    Oral presentation

  • 視索症候群の網膜神経線維層厚

    辰巳 康子, KANAMORI,Akiyasu, 中西 頼子, 永井 あづさ, KUSUHARA, Sentaro, YAMADA, Yuko, NAKAMURA, Makoto, SEKIYA,Yoshibumi, NEGI, Akira

    第41回日本神経眼科学会, Dec. 2003, Japanese, 日本神経眼科学会, 京都, Domestic conference

    Oral presentation

  • Band atrophyにおけるOCTによる網膜神経線維層厚の解析

    松井 敬子, KANAMORI,Akiyasu, 中西 頼子, 永井 あづさ, KUSUHARA, Sentaro, YAMADA, Yuko, NAKAMURA, Makoto, SEKIYA,Yoshibumi, NEGI, Akira

    第41回日本神経眼科学会, Dec. 2003, Japanese, 日本神経眼科学会, 京都, Domestic conference

    Oral presentation

  • 線維柱帯切除術の術後中期成績~輪部基底結膜切開と円蓋部基底結膜切開の比較~

    永井 あづさ, KANAMORI,Akiyasu, YAMADA, Yuko, MATSUBARA,Satoshi, NAKAMURA, Makoto, NEGI, Akira

    第57回日本臨床眼科学会, Oct. 2003, Japanese, 日本臨床眼科学会, 名古屋, Domestic conference

    Oral presentation

  • 線維柱帯切除術の術後中期成績~輪部基底結膜切開と円蓋部基底結膜切開の比較

    永井 あづさ, KANAMORI,Akiyasu, 瀬谷 隆, YAMADA, Yuko, MATSUBARA,Satoshi, NAKAMURA, Makoto, NEGI, Akira

    第69回日本中部眼科学会、第100回中国四国眼科学会, Oct. 2003, Japanese, 日本中部眼科学会、中国四国眼科学会, 岡山, Domestic conference

    Oral presentation

  • 線維柱帯切開術の術後中期成績~輪部基底結膜切開と円蓋部基底結膜切開の比較~

    永井 あづさ, KANAMORI,Akiyasu, 瀬谷 隆, YAMADA, Yuko, MATSUBARA,Satoshi, NAKAMURA, Makoto, NEGI, Akira

    第103回兵庫県眼科医会学術集談会, Oct. 2003, Japanese, 日本眼科医会, 神戸大学, Domestic conference

    Oral presentation

  • 上下半視野による光干渉断層計を用いた網膜神経線維層厚の解析

    KANAMORI,Akiyasu, 瀬谷 隆, YAMADA, Yuko, MATSUBARA,Satoshi, NAKAMURA, Makoto, NEGI, Akira

    第69回日本中部眼科学会、第100回中国四国眼科学会, Oct. 2003, Japanese, 日本中部眼科学会、, 岡山, Domestic conference

    Oral presentation

  • 上下半視野におけるOCTによる網膜神経線維層厚の解析

    KANAMORI,Akiyasu, 永井 あづさ, 瀬谷 隆, YAMADA, Yuko, MATSUBARA,Satoshi, NAKAMURA, Makoto, NEGI, Akira

    第57回日本臨床眼科学会, Oct. 2003, Japanese, 日本臨床眼科学会, 名古屋, Domestic conference

    Oral presentation

  • 上下半視野におけるOCTによる網膜神経線維層厚の解析

    KANAMORI,Akiyasu, 永井 あづさ, 瀬谷 隆, YAMADA, Yuko, MATSUBARA,Satoshi, NAKAMURA, Makoto, NEGI, Akira

    第103回兵庫県眼科医会学術集談会, Oct. 2003, Japanese, 日本眼科医会, 神戸大学, Domestic conference

    Oral presentation

  • 眼圧変動に伴い視神経乳頭陥凹が著明な変化を繰り返した成人症例

    角谷 庸子, KANAMORI,Akiyasu, 瀬谷 隆, YAMADA, Yuko, MATSUBARA,Satoshi, NAKAMURA, Makoto, NEGI, Akira

    第14回日本緑内障学会, Jul. 2003, Japanese, 日本緑内障学会, 東京, Domestic conference

    Oral presentation

  • ラット慢性緑内障モデル網膜におけるAktの発現及びリン酸化

    KANAMORI,Akiyasu, 椋野 洋和, YAMADA, Yuko, MATSUBARA,Satoshi, NAKAMURA, Makoto, NEGI, Akira

    第14回日本緑内障学会, Jul. 2003, Japanese, 日本緑内障学会, 東京, Domestic conference

    Oral presentation

  • 神経線維腫症に合併した先天緑内障の1例

    福村 美帆, YAMADA, Yuko, KANAMORI,Akiyasu, 瀬谷 隆, MATSUBARA,Satoshi, NAKAMURA, Makoto, NEGI, Akira

    第59回日本弱視斜視学会総会、第28回日本小児眼科学会総会合同学会, Jun. 2003, Japanese, 日本弱視斜視学会、日本小児眼科学会, 神戸, Domestic conference

    Oral presentation

Association Memberships

  • 日本緑内障学会

  • 日本神経眼科学会

  • 日本弱視斜視学会

  • 日本小児眼科学会

  • 日本眼科学会

Research Projects