KUMAMOTO Etsuko | ![]() |
Information Science and Technology Center | |
Professor | |
Engineering / Other Field |
Sep. 2014 Interventional MRI Symposium 2014, Interventional MRI Symposium 2014, Poster Award, magna cum laude., Respiratory-induced Deformation Analysis of Liver using Branching Structure of Portal Vein for MR Images for HIFU
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Thermometry is the key factor for achieving successful thermal therapy. Although invasive thermometry with a probe has been used for more than four decades, this method can only detect the local temperature within the probing volume. Noninvasive temperature imaging using a tomographic technique is ideal for monitoring hot-spot formation in the human body. Among various techniques, such as X-ray computed tomography, microwave tomography, echo sonography, and magnetic resonance (MR) imaging, the proton resonance frequency shift method of MR thermometry is the only method currently available for clinical practice because its temperature sensitivity is consistent in most aqueous tissues and can be easily observed using common clinical scanners. New techniques are being proposed to improve the robustness of this method against tissue motion. MR techniques for fat thermometry were also developed based on relaxation times. One of the latest non-MR techniques to attract attention is photoacoustic imaging.
Elsevier BV, 2020, Advanced Drug Delivery Reviews, 163-164, 19 - 39, English, International magazine[Refereed][Invited]
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We currently utilize the Moodle learning management system for teachers and students who participate in the course 'College of Liberal Arts and Sciences' at Kobe University in Japan. Digital textbooks, reports, quizzes and questionnaires in this course were administered using Moodle. In this paper, we proposed to use quizzes to measure and evaluate those digital textbooks recorded on Moodle. At the beginning of our study, we examined the questions that students got lower scores, and then we found the related teaching materials of digital textbooks and feedback to the teachers in order to improve the content of these digital textbooks.
Nov. 2016, Proc. of 24th International Conference on Computers in Education 2016 (ICCE2016), 374 - 379, English[Refereed]
International conference proceedings
Magnetic resonance-guided focused ultrasound (MRgFUS) is becoming one of the foremost treatment options for uterine fibroids and breast cancer. However, for an abdominal organ such as the liver, a target tracking technique to “lock on” to the focal area is required because the organ moves and deforms with respiratory motion. This technique, which is based on the relative displacement of the portal vein using sagittal MR images, is effective for translational motion and deformation because blood flow is visualized as high intensity in MR images using TrueFISP. The aim of this study was to develop a three-dimensional target tracking technique based on the results of an analysis of three-dimensional dynamic information about the portal vein structure. It is difficult to acquire multi-slice images quickly using MR. Therefore, in this study, we propose a method to reconstruct a three-dimensional dynamic model of the liver using multi-slice MR images acquired during slow breathing. Forty-two frames of the image set were acquired during slow breathing. The images were arranged in breathing phase order based on the motion of the diaphragm. Interpolated images were enhanced using a morphology technique and were inserted between the discontinuous frames. Finally, the images were interpolated in isotropic voxels in an out-plane direction. The experimental results demonstrate the feasibility of three-dimensional tracking based on a portal vein tree structure.
Japan Soc. of Med. Electronics and Biol. Engineering, 29 Oct. 2015, Transactions of Japanese Society for Medical and Biological Engineering, 53 (3), 168 - 178, Japanese[Refereed]
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The MR-endoscope system can perform magnetic resonance (MR) imaging during endoscopy and show the images obtained by using endoscope and MR. The MR-endoscope system can acquire a high-spatial resolution MR image with an intraluminal radiofrequency (RF) coil, and the navigation system shows the scope's location and orientation inside the human body and indicates MR images with a scope view. In order to conveniently perform an endoscopy and MR procedure, the design of the user interface is very important because it provides useful information. In this study, we propose a navigation system using a wireless accelerometer-based controller with Bluetooth technology and a navigation technique to set the intraluminal RF coil using the navigation system. The feasibility of using this wireless controller in the MR shield room was validated via phantom examinations of the influence on MR procedures and navigation accuracy. In vitro examinations using an isolated porcine stomach demonstrated the effectiveness of the navigation technique using a wireless remote-control device.
2013, Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, 2013, 5698 - 701, English, International magazine[Refereed]
International conference proceedings
The goal of this study is to establish novel medical technologies by combining magnetic resonance imaging (MRI) with endoscopy to improve diagnostic precision and the safety of endoscopic surgeries. One of the key components of the integrated magnetic resonance (MR) endoscope system is a radio-frequency (RF) coil; this detects the MR signal from tissue and should be placed inside the body. Resonance characteristics such as the resonant frequency and the impedance of the RF coil, which affect the quality of MR images, change depending on the electric properties of the surrounding tissue and the coil deformation. Therefore, the technique of remote tuning and matching of the RF coil was developed, and its feasibility was investigated using a developed intracavitary RF coil, 1.5 tesla MR scanner, and models of phantom and resected porcine stomach. As a result, the frequency tuning and impedance matching was remotely adjusted in both models. In addition, the signal-to-noise ratio (SNR) of MR images was improved up to 134%. The developed remote tuning and matching technique was able to adjust the resonant characteristics of RF coil and can contribute the improvement of MR image quality, which would facilitate safe and precise endoscopy and endoscopic surgeries.
IEEE, 2013, 2013 35TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC), 5706 - 5710, English[Refereed]
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The purpose of this study was to evaluate a novel vessel-tracking-based technique for tracking of human liver. The novelty of the proposed technique is that it measures the translation and deformation of a local tissue region based on the displacements of a set of vessels of interest instead of the entire organ. The position of the target point was estimated from the relative positions of the center-of-masses of the vessels, assuming that the topological relationship between the target point and center-of-masses is unchanged during breathing. To reduce inaccuracy due to the delay between vessel image acquisition and sonication, the near-future target position was predicted based on the vessel displacements in the images extracted from an image library acquired before the tracking stage. Experiments on healthy volunteers demonstrated that regardless of the respiratory condition, appropriate combinations of three center-of-masses from the vessels situated around the target-tissue position yielded an estimation error of less than 2 mm, which was significantly smaller than that obtained when using a single center-of-mass trio. The effect of the tracking delay was successfully compensated, with a prediction error of less than 3 mm, by using over four images selected from the image library. Magn Reson Med, 2011. (C) 2011 Wiley-Liss, Inc.
WILEY-BLACKWELL, Jan. 2012, MAGNETIC RESONANCE IN MEDICINE, 67 (1), 156 - 163, English[Refereed]
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Purpose The laparoscope has been invaluable in minimally invasive surgery, but provides only a surface view of target tissue; therefore it is lacking internal tissue information. In combination with the laparoscope for visualizing the cross-sectional view of the tissue, MRI is superior to ultrasonography or X-ray CT, because of its high soft-tissue contrast, arbitrary slice orientation and lack of radiation properties. Thus, we propose an integrated MR-laparoscopy system with a respiratory-synchronized navigation. Methods A transmit/receive RF coil for localized MR imaging with a 0.5 T open-MRI was mounted onto the tip of an MR-compatible laparoscope. The signal detection of the coil was examined with an excised porcine liver sample, an agar phantom and the abdominal wall of a healthy volunteer. A real-time navigation system to compensate for respiratory motion was developed, and examined with a healthy volunteer. Results The SNRs of the local MR images were 112, 62, and 62 in the liver sample, phantom, and volunteer. The navigation system successfully displayed the scope view, scope location and orientation, and MR images with respiratory-synchronized real time operation. Conclusions The MR-imaging and synchronization function of the proposed system seemed to be helpful for laparoscopic surgery.
SPRINGER TOKYO, Sep. 2010, JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES, 17 (5), 622 - 628, English[Refereed]
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Recently, several new endoscopic instruments have been developed. However, even with the full use of current modalities, the safety of endoscopic surgery is not guaranteed. Information regarding factors such as fibrosis and the blood vessels under the mucosa is very important for avoiding procedure-related complications. The aim of this study was to define the detailed anatomy of the gastric wall structure in vivo using original endoluminal radiofrequency coils for safer endoscopic therapy.Swine were used as the subjects and controlled with general anesthesia. Anatomical images were obtained with T1-weighted fast spin echo (T1FSE) and T2-weighted fast spin echo (T2FSE). Dynamic magnetic resonance (MR) angiography was also obtained with three-dimensional T1-weighted fast spoiled gradient recalled acquisition in the steady state (3D-DMRA) following the injection of hyaluronic acid sodium into the submucosal layer.Porcine gastric wall structure was visualized, and four layers were discriminated in the T1FSE and T2FSE images. The vascular structure was clearly recognized in the submucosa on 3D-DMRA.Endoluminal MR imaging was able to visualize the porcine stomach with similar quality to endoscopic ultrasonography imaging. Additionally, it was possible to visualize the vascular structures in the submucosal layer. This is the first report to show that blood vessels under the gastric mucosa can be depicted in vivo.
SPRINGER JAPAN KK, Jun. 2010, JOURNAL OF GASTROENTEROLOGY, 45 (6), 600 - 607, English[Refereed]
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The purpose of this study was to visualize the gastric wall layers and to depict the vascular architecture in vitro by using resected porcine stomachs studied with high-spatial resolution magnetic resonance (MR) imaging. Normal dissected porcine stomach samples (n = 4) were examined with a 3 Tesla MR system using a newly developed surface coil. MR images were obtained by the surface coil as receiver and a head coil as transmitter. High-spatial-resolution spin-echo MR images were obtained with a field of view of 8 x 8 cm, a matrix of 256 x 128 and slice thicknesses of 3 and 5 mm. T1 and T2-weighted MR images clearly depicted the normal porcine gastric walls as consisting of four distinct layers. In addition, vascular architectures in proper muscle layers were also visualized, which were confirmed by histological examinations to correspond to blood vessels. High-spatial-resolution MR imaging using a surface coil placed closely to the gastric wall enabled the differentiation of porcine gastric wall layers and the depiction of the blood vessels in proper muscle layer in this experimental study.
SPRINGER TOKYO, May 2009, JOURNAL OF GASTROENTEROLOGY, 44 (5), 390 - 395, English[Refereed]
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The purpose of this work is to develop a magnetic resonance (MR) technique for guiding a focal point created in Focused Ultrasound Surgery (FUS) onto a specific target position in an abdominal organ, such as the liver, which moves and deforms with respiratory motion. The translational distance, rotational angles, and amount of expansion and contraction of the organ tissue were measured by obtaining the gravity points of the veins filtered from the sagittal, cine MR images of healthy livers during free breathing. Using the locations of the vessels at each time point, the target position at which the ultrasound focus was to be placed was estimated. In the volunteer experiments (N = 2), the lower limit of the spatial matrix dimension for delineating the veins was 128 x 128. The average displacement of the liver was 19.6 +/- 3.6 mm in superior-inferior (SI) direction and 3.1 +/- 1.4 mm in anterior-posterior (AP) direction. The deformations were 3.7 +/- 1.1 mm in SI direction and 3.0 +/- 1.2 mm in AP direction. The error between the actual and the estimated target point was 0.7 +/- 0.5 mm in SI direction, 0.6 +/- 0.4 mm in AP direction and 1.0 +/- 0.5 mm in distance, and less than 2.1 mm in all the trials. These results suggested that the proposed technique is sufficient for targeting the focus on a specific tissue location and for tracking the slice slab for thermometry to cover the region of focus.
IEEE, 2007, 2007 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-16, 2614 - 2617, English[Refereed]
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The purpose of this work is to develop a magnetic resonance (MR) technique for guiding a focal point created in Focused Ultrasound Surgery (FUS) onto a specific target position in an abdominal organ, such as the liver, which moves and deforms with respiratory motion. The translational distance, rotational angles, and amount of expansion and contraction of the organ tissue were measured by obtaining the gravity points of the veins filtered from the sagittal, cine MR images of healthy livers during free breathing. Using the locations of the vessels at each time point, the target position at which the ultrasound focus was to be placed was estimated. In the volunteer experiments (N = 2), the lower limit of the spatial matrix dimension for delineating the veins was 128 x 128. The average displacement of the liver was 19.6 ±3.6 mm in superior-inferior (SI) direction and 3.1 ±1.4 mm in anterior-posterior (AP) direction. The deformations were 3.7 ± 1.1 mm in SI direction and 3.0 ±1.2 mm in AP direction. The error between the actual and the estimated target point was 0.7 ± 0.5 mm in SI direction, 0.6 ±0.4 mm in AP direction and 1.0 ± 0.5 mm in distance, and less than 2.1 mm in all the trials. These results suggested that the proposed technique is sufficient for targeting the focus on a specific tissue location and for tracking the slice slab for thermometry to cover the region of focus. © 2007 IEEE.
2007, Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, 2614 - 2617, English[Refereed]
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The purpose of this work is to develop a magnetic resonance (MR) technique for guiding a focal point created in Focused Ultrasound Surgery (FUS) onto a specific target position in an abdominal organ, such as the liver, which moves and deforms with respiratory motion. The translational distance, rotational angles, and amount of expansion and contraction of the organ tissue were measured by obtaining the gravity points of the veins filtered from the sagittal, cine MR images of healthy livers during free breathing. Using the locations of the vessels at each time point, the target position at which the ultrasound focus was to be placed was estimated. In the volunteer experiments (N = 2), the lower limit of the spatial matrix dimension for delineating the veins was 128 x 128. The average displacement of the liver was 19.6 +/- 3.6 mm in superior-inferior (SI) direction and 3.1 +/- 1.4 mm in anterior-posterior (AP) direction. The deformations were 3.7 +/- 1.1 mm in SI direction and 3.0 +/- 1.2 mm in AP direction. The error between the actual and the estimated target point was 0.7 +/- 0.5 mm in SI direction, 0.6 +/- 0.4 mm in AP direction and 1.0 +/- 0.5 mm in distance, and less than 2.1 mm in all the trials. These results suggested that the proposed technique is sufficient for targeting the focus on a specific tissue location and for tracking the slice slab for thermometry to cover the region of focus.
2007, Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2007, 2614 - 7, English, International magazineScientific journal
Recently many researchers discuss the desirable curriculum of information education in undergraduate course due to the renewal of curriculum in high school. In order to reveal the learning opportunities in the previous curriculum, the authors conducted a survey regarding the initial learning opportunity before entering university in the previous curriculum. The results show that many students in the previous curriculum have not had enough learning experiences in expansive area. Even if students have learned such area, they have tended to study by themselves. Students who graduated from priv...
Japan Society for Educational Technology, 20 Dec. 2006, Japan journal of educational technology, 30 (3), 259 - 267, Japanese[Refereed]
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Referenceless, or self-reference, thermometry is a technique for mapping temperature differences in the region of interest (ROI) using the baseline phase estimated by extrapolating the field in the surrounding region for estimation (RFE) and subtracting the estimated baseline from the measured field. In the present work a self-reference technique based on complex field estimation using 2D polynomials comprising complex-valued coefficients was proposed and optimized. Numerical simulations with a Gaussian-profiled phase distribution demonstrated that the ROI radius had to be 2.3-2.5 times the standard deviation (SD) of the Gaussian function in order to keep the error below 8% of the peak phase change. The area ratio between the ROI and the RFE had to be larger than 2.0 to maintain the error level. Based on the simulations, and phantom and volunteer experiments, the complex-based method with independently optimized polynomial orders for the two spatial dimensions was compared with the phase-based method using the similar-order optimization strategy. The complex-based method appeared to be useful when phase unwrapping was not removed. Otherwise, the phase-based method yielded equivalent results with less polynomial orders.
JOHN WILEY & SONS INC, Oct. 2006, MAGNETIC RESONANCE IN MEDICINE, 56 (4), 835 - 843, English[Refereed]
Scientific journal
Referenceless, or self-reference, thermometry is a technique for mapping temperature differences in the region of interest (ROI) using the baseline phase estimated by extrapolating the field in the surrounding region for estimation (RFE) and subtracting the estimated baseline from the measured field. In the present work a self-reference technique based on complex field estimation using 2D polynomials comprising complex-valued coefficients was proposed and optimized. Numerical simulations with a Gaussian-profiled phase distribution demonstrated that the ROI radius had to be 2.3-2.5 times the standard deviation (SD) of the Gaussian function in order to keep the error below 8% of the peak phase change. The area ratio between the ROI and the RFE had to be larger than 2.0 to maintain the error level. Based on the simulations, and phantom and volunteer experiments, the complex-based method with independently optimized polynomial orders for the two spatial dimensions was compared with the phase-based method using the similar-order optimization strategy. The complex-based method appeared to be useful when phase unwrapping was not removed. Otherwise, the phase-based method yielded equivalent results with less polynomial orders.
JOHN WILEY & SONS INC, Oct. 2006, MAGNETIC RESONANCE IN MEDICINE, 56 (4), 835 - 843, English[Refereed]
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Referenceless, or self-reference, thermometry is a technique for mapping temperature differences in the region of interest (ROI) using the baseline phase estimated by extrapolating the field in the surrounding region for estimation (RFE) and subtracting the estimated baseline from the measured field. In the present work a self-reference technique based on complex field estimation using 2D polynomials comprising complex-valued coefficients was proposed and optimized. Numerical simulations with a Gaussian-profiled phase distribution demonstrated that the ROI radius had to be 2.3-2.5 times the standard deviation (SD) of the Gaussian function in order to keep the error below 8% of the peak phase change. The area ratio between the ROI and the RFE had to be larger than 2.0 to maintain the error level. Based on the simulations, and phantom and volunteer experiments, the complex-based method with independently optimized polynomial orders for the two spatial dimensions was compared with the phase-based method using the similar-order optimization strategy. The complex-based method appeared to be useful when phase unwrapping was not removed. Otherwise, the phase-based method yielded equivalent results with less polynomial orders.
JOHN WILEY & SONS INC, Oct. 2006, MAGNETIC RESONANCE IN MEDICINE, 56 (4), 835 - 843, English[Refereed]
Scientific journal
Referenceless, or self-reference, thermometry is a technique for mapping temperature differences in the region of interest (ROI) using the baseline phase estimated by extrapolating the field in the surrounding region for estimation (RFE) and subtracting the estimated baseline from the measured field. In the present work a self-reference technique based on complex field estimation using 2D polynomials comprising complex-valued coefficients was proposed and optimized. Numerical simulations with a Gaussian-profiled phase distribution demonstrated that the ROI radius had to be 2.3-2.5 times the standard deviation (SD) of the Gaussian function in order to keep the error below 8% of the peak phase change. The area ratio between the ROI and the RFE had to be larger than 2.0 to maintain the error level. Based on the simulations, and phantom and volunteer experiments, the complex-based method with independently optimized polynomial orders for the two spatial dimensions was compared with the phase-based method using the similar-order optimization strategy. The complex-based method appeared to be useful when phase unwrapping was not removed. Otherwise, the phase-based method yielded equivalent results with less polynomial orders.
JOHN WILEY & SONS INC, Oct. 2006, MAGNETIC RESONANCE IN MEDICINE, 56 (4), 835 - 843, English[Refereed]
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Our challenge was to design and implement a dedicated temperature imaging feedback control system to guide and assist in a thermal liver ablation procedure in a double-donut 0.5T open MR scanner. This system has near-real-time feedback capability based on a newly developed "self-referenced" temperature imaging method using "moving-slab" and complex-field-fitting techniques. Two phantom validation studies and one ex vivo experiment were performed to compare the newly developed self-referenced method with the conventional subtraction method and evaluate the ability of the feedback control system in the same MR scanner. The near-real-time feedback system was achieved by integrating the following primary functions: (1) imaging of the moving organ temperature; (2) on-line needle tip tracking; (3) automatic turn-on/off the heating devices; (4) a Windows operating system-based novel user-interfaces. In the first part of the validation studies, microwave heating was applied in an agar phantom using a fast spoiled gradient recalled echo in a steady state sequence. In the second part of the validation and ex vivo study, target visualization, treatment planning and monitoring, and temperature and thermal dose visualization with the graphical user interface of the thermal ablation software were demonstrated. Furthermore, MR imaging with the "self-referenced" temperature imaging method has the ability to localize the hot spot in the heated region and measure temperature elevation during the experiment. In conclusion, we have demonstrated an interactively controllable feedback control system that offers a new method for the guidance of liver thermal ablation procedures, as well as improving the ability to assist ablation procedures in an open MR scanner. (c) 2006 Elsevier Ireland Ltd. All fights reserved.
ELSEVIER IRELAND LTD, Aug. 2006, EUROPEAN JOURNAL OF RADIOLOGY, 59 (2), 175 - 182, English[Refereed]
Scientific journal
Our challenge was to design and implement a dedicated temperature imaging feedback control system to guide and assist in a thermal liver ablation procedure in a double-donut 0.5T open MR scanner. This system has near-real-time feedback capability based on a newly developed "self-referenced" temperature imaging method using "moving-slab" and complex-field-fitting techniques. Two phantom validation studies and one ex vivo experiment were performed to compare the newly developed self-referenced method with the conventional subtraction method and evaluate the ability of the feedback control system in the same MR scanner. The near-real-time feedback system was achieved by integrating the following primary functions: (1) imaging of the moving organ temperature; (2) on-line needle tip tracking; (3) automatic turn-on/off the heating devices; (4) a Windows operating system-based novel user-interfaces. In the first part of the validation studies, microwave heating was applied in an agar phantom using a fast spoiled gradient recalled echo in a steady state sequence. In the second part of the validation and ex vivo study, target visualization, treatment planning and monitoring, and temperature and thermal dose visualization with the graphical user interface of the thermal ablation software were demonstrated. Furthermore, MR imaging with the "self-referenced" temperature imaging method has the ability to localize the hot spot in the heated region and measure temperature elevation during the experiment. In conclusion, we have demonstrated an interactively controllable feedback control system that offers a new method for the guidance of liver thermal ablation procedures, as well as improving the ability to assist ablation procedures in an open MR scanner. (c) 2006 Elsevier Ireland Ltd. All fights reserved.
ELSEVIER IRELAND LTD, Aug. 2006, EUROPEAN JOURNAL OF RADIOLOGY, 59 (2), 175 - 182, English[Refereed]
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The self-reference method is a magnetic resonance (MR) thermometry method for mapping temperature changes in a target organ using the baseline phase field in a region of interest (ROI) estimated by the polynomial extrapolation of the field in the surrounding region (s) for estimating (RFE) and subtracting the baseline from the measured field. In the present work, optimization of the ROI and RFE to adopt this technique to MR-guided focused ultrasound surgery (MRgFUS) of uterine fibroid was examined. Both numerical simulation with the Gaussian-profiled heating region and application to clinic...
Japanese Society for Medical and Biological Engineering, 10 Dec. 2005, Transactions of the Japanese Society for Medical and Biological Engineering : BME, 43 (4), 585 - 594, JapaneseApplication of the self-referenced method of magnetic resonance (MR) thermometry to focused ultrasound surgery (FUS) was examined. The temperature elevation values obtained by the technique in uterine fibroid treatments differed only for 2.99 ± 1.73°C from those by the conventional method when it was worse case in coronal slice, demonstrating usefulness and viability of the technique. © 2005 SICE.
Aug. 2005, Proc. SICE Annual Meeting 2005 in Okayama, 922 - 927, English[Refereed]
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The reconstruction of three dimensional structure of cerebral arteries from two dimensional cineangiograms is useful to extract three dimensional information in the angiograms. In this paper, we consider the extraction of vessel center lines from the cineangiograms, which is a basic and important process for the three dimensional reconstruction. As the structure of cerebral arteries is extremely complicated and the vessel regions on the cineangiograms cross and overlap with each other, it is difficult to extract vessel center lines. A framewise extraction method is developed in this study, which repeats the vessel extraction upon each of a series of cineangiograms. On each frame, the system selects a proper image processing algorithm and parameters for the vessels under processing. The extraction method combines both the edge detection and the segmentation to improve the accuracy of vessel extraction from a single frame of cineangiograms. A vessel examining process is also proposed, which evaluates the possibility of extracted center lines being real cerebral arteries. The knowledge about cerebral arteries as well as that of cineangiograms is utilized in the processes for vessel extraction and vessel examination to improve the accuracy of the extraction results. © 1993, Japanese Society for Medical and Biological Engineering. All rights reserved.
1993, Japanese journal of medical electronics and biological engineering, 31 (1), 37 - 46, English[Refereed]
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X-ray Computerliged tomography (CT) and nuclear magnetic resonance (NMR) - CT images are usually obtained as a series of two -dimensional images. We have to reconstruct the three -dimensional shapes from those cross sectional images. Surface models as well as solid models are used to represent the three dimensional images. This paper proposed a triangulation algorithm based on some criteria by using the directed graph theory together with dynamic programming (DP) to reconstruct the three -dimensional surface model. Some simple examples according to the minimum surface criterion showed that ...
Kobe University, 1995, 神戸大学医学部保健学科紀要, 11 (0), 23 - 29, JapaneseIn the external beam radiotherapy, it is required to optimize the number of beams, the beam angles and the strength of irradiation which deliver the desired dose to the tumour while limiting the dose absorbed in the normal tissue. Mathematical programming techniques are reported to be useful to solve this optimization problem with various types of formulation. In this study, we formulate this problem as a Linear Programming (LP) problem minimizing the mean dose in a buffer region, which is a region located around the tumour to ensure the effectiveness of the solution and the availability of the feasible solution. An illustrative plan of a treatment of cerebral tumour is given to demonstrate the effectiveness of the proposed method. © 1995, Japanese Society for Medical and Biological Engineering. All rights reserved.
日本エム・イー学会, 1995, Japanese journal of medical electronics and biological engineering, 33 (4), 301 - 309, EnglishAegagropila linnaei are natural monuments of Japan and in danger of extinction. However, the formation of Marimos has been unresolved. For the clarification of the creation of Aegagropila linnaei, a numerical computation is one of the most powerful techniques, such as a Distinct Element Method (DEM). We attempted to estimate two significant parameters for DEM, elastic modulus and viscosity coefficients of Aegagropila linnaei by applying laboratory experiments, which revealed that two parameters are constant regardless of size and density. Furthermore, we investigated Marimos by using Magnetic Resonance Imaging, which allows non-destructive investigation of Marimos underwater. The base of Marimos is revealed to move from the outer edge to the centre of Aegagropila linnaei when they grow.
Japan Society of Civil Engineers, 2020, Journal of Japan Society of Civil Engineers, Ser. B1 (Hydraulic Engineering), 76 (2), I_1267 - I_1272, JapanesePoster presentation
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本研究はこれまで比較的動きの少ない臓器に適用されてきた磁気共鳴画像化法(Magnetic Resonance Imaging, MRI)を組み合わせた集束超音波治療(Focused Ultrasound Surgery, FUS)の適用範囲を広げ,より有用な治療法としていくため,臓器の三次元的な呼吸性移動・変形に追従して集束超音波の照射位置を追尾,さらには照射位置の予測による集束超音波の照射制御手法の確立を目指すものである.今年度は特に以下の点について,検討を行った.(1)肝臓の三次元的呼吸性移動・変形の解明呼吸による肝臓の三次元的な移動・変形のパターンを抽出するために,高速撮像法であるFIESTAを用いて,健常ボランティアの肝臓を三次元撮像した.撮像は最大吸気,最大呼気およびその中間での息止めによるマルチスライス画像を取得し,肝臓の血管の三次元再構成を行い,構造解析を行って樹状構造を構築した.さらに,1周期あたり20秒程度のゆっくりとした呼吸で,1呼吸サイクルで10セット程度のマルチスライスを取得し,横隔膜の位置
Competitive research funding
アスベスト肺とそれに伴う中皮腫の自動診断システムを開発した。アスベスト肺と中皮腫の高い精度での診断はかなり困難であるが、X線ヘリカルCTを用いた3次元画像情報を基に自動診断システムを作り、放射線科医や呼吸器内科医の診断の支援システムを作成した。システムについて精度を測定するためにROC解析を行い、統計的に明らかに精度が向上することが証明された。
Competitive research funding
肝臓のように呼吸によって動く腹腔臓器に対する集束超音波治療とその際の非侵襲温度モニタリングを行なうために磁気共鳴画像化(MRI)を用いた方法を検討した. 肝臓門脈の断面像の変位から肝組織の動き・変形を実測し, 加温目標点を追尾する方法を提案した.複素磁気共鳴信号の位相から温度分布を求める際の, 画像引き算過程を排除した方法(自己参照法)と組み合わせ, 肝のMRIガイド下集束超音波治療の要素技術を確立した
Competitive research funding
MR撮像に用いられる傾斜磁場がMR装置内でほぼ線形に変化することに着目し, 治療デバイス先端に傾斜磁場による磁束の変化をとらえるコイルを配置して, リアルタイムで治療デバイスの位置・姿勢を測定するシステム, また治療デバイス先端にMR画像で高輝度となるマーカを取り付け, 多方向からのプロジェクションデータを解析することによりデバイスの位置・姿勢を検出するシステムを提案した。更に, MR装置と内視鏡を融合させたMR-内視鏡システムにおいて, これらの位置姿勢検出システムから得られた情報をもとに, 内視鏡の光学像とMR画像の重畳表示を行った.
Competitive research funding
Competitive research funding
The research concerns to develop basic tools to construct a distributed virtual factory (DVF) for the support of strategic decision making under e- business environment and to seek the effectiveness of DVF in applying the studies of artificial market and/or virtual enterprise. The major research results are listed as follows:1.Concept and Modeling tools of DVF(1)A distributed virtual factory concept is proposed to develop a large scale manufacturing system based on distributed simulation technology. As basic tools to construct a DVF, communication interfaces for various simulation languages...
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In this study we investigate a manufacturing system with machining centers (MC) that can produce the variety of products with varying volume efficiently. A square arrayed layout of MCs is proposed with an auction based method for the operation as an extension of a serial-parallel layout. The given number of MCs, which is estimated for a given production plan are located on square grid points. Each MC holds toolsets for all processes of all products. An auction based method is applied to select an MC for the next processing of a pallet at the pallet changing station.By applying various bid t...
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We presume in this study that a virtual enterprise will be formed by selecting members applied for a supply chain of a product. We postulated two models in the below to form a VE which will be characterized by the existence of a leader in the supply chain to reach the mutual agreement or consensus.1. The consensus is attained in the negotiation process to select members from the sales agent to the agents in the market at the upstream of the supply chain.2. A leader governing the supply chain will select the members from the market.We studied mainly on the first model from the view points su...
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Agile manufacturing has attracted a considerable attention as a new manufacturing concept for next generation which quickly responds to a rapidly varying and personalizing demands of customers. In this study, a high volume manufacturing system for automotive industries is investigated focusing on the capability to replace and/or to supplement the mass production system in order to materialize the agile manufacturing. The system configuration of the proposed system together with its operational system was studied to clarify the characteristics and the conformity of the system to agile manufa...
Competitive research funding
本研究では,多様化,個性化する製品に対する顧客の要求に迅速に応えるための次世代の生産体制であるアジャイル生産に適合した大容量,高速のFMS(HV-FMS)を構築するために必要なシステム設計と運用の方法論について研究することを目的とした.なお,基礎研究として,自動車産業における量産設備の代替,補完性に焦点を絞り,以下の成果を得た.まず,自動車産業における量産機能としてのアジャイル性に関する基礎的考察を行い,大容量FMSの位置づけとそれに要求される基本機能について検討した.TL,FTLは計画生産能力の生産時に最高性能を発揮するが,現実の生産においては計画能力に対する生産量に過不足を生じる.また,新機種の立ち上げ時,旧機種の少量生産への対応などにも問題がある.従って,大容量FMSを以上のような問題に対する解決法の一つとして位置づけることとした.大容量・高速FMSの基本構成として,工程集約型の高速マシニングセンターを要素機械とするフレキシブルな生産システム
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In this study, we investigate to develop a simulation-based decision support system under computer integrated manufacturing. The activities in the factory are modeled and expressed in a "virtual manufacturing system" (VMS) which is an internal model developed in a comput system. We focused to realize an autonomously distributed VMS as a distributed simulation system in this study in accord with the following considenration : the distributed information network will become an essential infrastructure in future factories, the distributed processing is effective to attain the high speed corres...
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平成3年度の研究をさらに発展させると共に,その成果を基礎として,以下の研究を推進し,成果を得た.1.分散型シミュレーション・システムの実験環境の整備 分散型シミュレーションに関する技術的問題とその解決法について実験的に考察するため,本研究で導入した機器を用いて分散型情報処理環境を構築し,様々なシミュレーション・システムを評価しうる環境を整えた.2.分散型シミュレーションのための同期法の検討 分散型シミュレーション・システムを構築するためには,システムを構成する各計算機の遂行するシミュレーションの進行を調整し,同期をとることが必要である.従来から提案されている同期法の適用可能性の検討を行うとともに,大規模な生産システムを取り扱うのに適した同期法について検討し,シミュレーション・システムの開発を行った.3.CIM環境を想定した実験的仮想生産システムの試作 CIMの計画段階及び運用段階における分散型シミュレーションの使用について考察
Competitive research funding
生産時点情報管理(Point Of Production)は,コンピュータ統合生産(CIM)システムを効率的に運用するために重要である.より高い生産性を実現するためには,POPシステムによって得られるリアルタイム性の高い,精密な情報の利用法と,その評価法について検討を行うことが必要となる.本研究では,それらに対して次のような成果を得た.・日程計画やスケジューリングは,生産性に大きく影響する.スケジューリングに対して,POP情報の最も有効な使用法として考えられることは,工場現場の状況と計画のずれをリアルタイム的に検知し,計画に修正を加え,その新しい計画を即座に現場に伝達するというリスケジューリング機能への適用である.本研究では,POP情報を得られることを前提とした,リスケジューリングの実行タイミングの具体的な決定法を開発し,その有効性をシミュレーションにより示した.・CIMのようなシステムを評価するためには,工場内の生産性だけでなく,経済性等の面から総合的に評価する必
Competitive research funding
Competitive research funding
Competitive research funding
文字・図形描画装置
特願平2-203984, 02 Aug. 1990, 富士ゼロックス株式会社, 特開平4-090595, 24 Mar. 1992, 特許第3018426号, 07 Jan. 2000Patent right
文字・図形描画装置
特願平2-223498, 24 Aug. 1990, 富士ゼロックス株式会社, 特開平4-104296, 06 Apr. 1992, 特許第2726951号, 12 Dec. 1997Patent right
ジエチレントリアミンペンタ酢酸錯体ポリマー組成物
特願2004-052208, 26 Feb. 2004, バンドー化学株式会社, 財団法人先端医療振興財団, 特開2005-239641, 08 Sep. 2005Patent right